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Conserved domains on  [gi|1333551220|ref|XP_023473462|]
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N-acetylgalactosamine kinase isoform X1 [Equus caballus]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 11-457 2.84e-164

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 472.66  E-value: 2.84e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 164 LGMNLSKVELAEICTKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 241
Cdd:PLN02521  182 LGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 242 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 311
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 312 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 385
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551220 386 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 457
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-457 2.84e-164

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 472.66  E-value: 2.84e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 164 LGMNLSKVELAEICTKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 241
Cdd:PLN02521  182 LGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 242 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 311
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 312 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 385
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551220 386 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 457
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-454 5.38e-89

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 275.88  E-value: 5.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEIC 177
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 178 TKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 255
Cdd:COG0153   155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 256 LAKskslpwdKVLRleevqarlRVSLEEmllitedalhpepyspeevcsclgisLQELRTQILSPntqdvlifKLYQRAK 335
Cdd:COG0153   234 LGV-------KSLR--------DVTLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 336 HVYSEAARVLQFKKICEEapDNMvQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIV 414
Cdd:COG0153   265 HVVTENQRVLEAVEALRA--GDL-EAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1333551220 415 PADKLPSFLANVHEAYYQRSDRSLapekqSLFATKPGGGA 454
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEKTGLEP-----DFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-455 3.98e-81

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 255.90  E-value: 3.98e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICT 178
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 179 KSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKLL 256
Cdd:TIGR00131 158 VAEnHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 257 AKskslPWDKVLR--LEEVQARLRVSLEEMLLITEdalhpepyspeevcsclgislqelrtqilspntqdvlifklyQRA 334
Cdd:TIGR00131 237 AA----TDKGALRdfMNEYFARYIARLTKMLPLVE------------------------------------------ERA 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 335 KHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSI 413
Cdd:TIGR00131 271 KHVVSENLRVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHL 347

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1333551220 414 VPADKLPSFLANVHEAYYQRSDrslAPEKQSLFATKPGGGAL 455
Cdd:TIGR00131 348 VPNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 1.86e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551220  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-457 2.84e-164

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 472.66  E-value: 2.84e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 164 LGMNLSKVELAEICTKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 241
Cdd:PLN02521  182 LGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 242 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 311
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 312 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 385
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551220 386 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 457
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-454 5.38e-89

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 275.88  E-value: 5.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEIC 177
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 178 TKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 255
Cdd:COG0153   155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 256 LAKskslpwdKVLRleevqarlRVSLEEmllitedalhpepyspeevcsclgisLQELRTQILSPntqdvlifKLYQRAK 335
Cdd:COG0153   234 LGV-------KSLR--------DVTLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 336 HVYSEAARVLQFKKICEEapDNMvQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIV 414
Cdd:COG0153   265 HVVTENQRVLEAVEALRA--GDL-EAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1333551220 415 PADKLPSFLANVHEAYYQRSDRSLapekqSLFATKPGGGA 454
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEKTGLEP-----DFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-455 3.98e-81

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 255.90  E-value: 3.98e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICT 178
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 179 KSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKLL 256
Cdd:TIGR00131 158 VAEnHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 257 AKskslPWDKVLR--LEEVQARLRVSLEEMLLITEdalhpepyspeevcsclgislqelrtqilspntqdvlifklyQRA 334
Cdd:TIGR00131 237 AA----TDKGALRdfMNEYFARYIARLTKMLPLVE------------------------------------------ERA 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 335 KHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSI 413
Cdd:TIGR00131 271 KHVVSENLRVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHL 347

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1333551220 414 VPADKLPSFLANVHEAYYQRSDrslAPEKQSLFATKPGGGAL 455
Cdd:TIGR00131 348 VPNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
PRK05101 PRK05101
galactokinase; Provisional
 23-434 4.74e-50

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 174.73  E-value: 4.74e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  23 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQL--ANTNPLYPDFSTSAnNV 100
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViaADYDNQQDEFSLDA-PI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 101 QIDKTKpLWHNYFLCGFKGIQEHfgLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICTKS 180
Cdd:PRK05101   85 VPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 181 E-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKLLAKs 259
Cdd:PRK05101  162 EnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFGV- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 260 kslpwdKVLR---LEEVQARlrvsleemllitEDALHPEpyspeevcsclgislqelrtqilspntqdvlifkLYQRAKH 336
Cdd:PRK05101  240 ------KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKRARH 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 337 VYSEAARVLQFKKICEEapDNMVqLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSIV 414
Cdd:PRK05101  268 VITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALV 344

                         410       420
                  ....*....|....*....|
gi 1333551220 415 PADKLPSFLANVHEAYYQRS 434
Cdd:PRK05101  345 PEELVEAVRQAVAEQYEAKT 364
PRK05322 PRK05322
galactokinase; Provisional
 23-430 6.20e-49

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 171.96  E-value: 6.20e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  23 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD---FSTSA 97
Cdd:PRK05322    5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  98 NNVQIDKtKPLWHNYFLCGFKGIQEHfGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEIC 177
Cdd:PRK05322   81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 178 TKSE-RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVKLpsgavfVIAHScvemNKA---ATSHFNIRV 246
Cdd:PRK05322  159 QKTEnEFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 247 MECRLAakllakskslpwdkvlrLEEVQARLRV-SLEEmllITEDALhpepyspEEvcsclgisLQELrtqILSPNtqdv 325
Cdd:PRK05322  229 AECEKA-----------------LEELQKKLDIkSLGE---LTEEEF-------DE--------YSYL---IKDET---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 326 lifkLYQRAKHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGA 404
Cdd:PRK05322  267 ----LLKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                         410       420
                  ....*....|....*....|....*.
gi 1333551220 405 GWGGCTVSIVPADKLPSFLANVHEAY 430
Cdd:PRK05322  340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK03817 PRK03817
galactokinase; Provisional
 40-433 1.84e-44

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 159.01  E-value: 1.84e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  40 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDMLIAVEPV-KTHtlqlantnpLYPDFSTSANNVQIDKTKPL--WHNYFLC 115
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSeKFI---------FYSENFNEEKTFELDKLEKLnsWADYIKG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 116 GFKGIQEHFGlsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICTKSER-YIGTEGGGMDQS 194
Cdd:PRK03817   73 VIWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 195 ISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIAHSCVEmNKAATSHFNIRVMECRLAAKLLAKSKSlpwdkvlrlEEVq 274
Cdd:PRK03817  151 AVAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSS---------KEV- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 275 arlrvsleemlliTEDALHpepyspeevcsclgiSLQELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEEa 354
Cdd:PRK03817  220 -------------TEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALKE- 254

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333551220 355 pdNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQR 433
Cdd:PRK03817  255 --GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 42-454 2.83e-27

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 112.26  E-value: 2.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  42 APGRVNIIGEHIDY-CGYSvLPMAVEQDMLIAVEPVKTHTLQLANtnplypDFSTSANNVQIDkTKPL----WHNYFLCG 116
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 117 FKGIQEHfGLSdLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICTKSER-YIGTEGGGMDQSI 195
Cdd:PRK00555   79 IWALRGA-GHP-VPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 196 SFLAEEGTAKLIEFSPLRATDVKLPSGA--VFVIAHSCVEMNKAATSHFNIRVMECRLAAKLLAKSKslpwdkvlrLEEV 273
Cdd:PRK00555  157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSS---------LRAV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 274 QARLRVSLeemllitedalhpepyspeevcsclgislqelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEe 353
Cdd:PRK00555  228 QDRGLAAL---------------------------------GAIADPID--------ARRARHVLTENQRVLDFAAALA- 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 354 apDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYyqr 433
Cdd:PRK00555  266 --DSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAA--- 340

                         410       420
                  ....*....|....*....|.
gi 1333551220 434 sdRSLAPEKQSLFATKPGGGA 454
Cdd:PRK00555  341 --VTAGYPEPAVSRTYAAPGA 359
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 1.86e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551220  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PLN02865 PLN02865
galactokinase
 183-456 4.34e-15

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 76.76  E-value: 4.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 183 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIAHSCVEMNKAATSHFNIRVMECRLAAKL 255
Cdd:PLN02865  184 YLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARF 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 256 LAKskslpwdkvlrleevqARLRVSLEEMLLITEdalhPEPYspeevcsclgislqELRTQILSPNtqdvlifkLYQRAK 335
Cdd:PLN02865  264 LLE----------------ASGNDELEPLLCNVE----PEVY--------------EAHKCKLEAV--------LARRAE 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 336 HVYSEAARVLqfkKICEEAPDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIV 414
Cdd:PLN02865  302 HYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFV 378

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1333551220 415 PADKLPSFLANVHEAYY--QRSDRSLAPEKQSLFATKPGGGALV 456
Cdd:PLN02865  379 DAEMAEEAASFVRDEYEkaQPELASNINGDKPVLICEAGDCARV 422
PTZ00290 PTZ00290
galactokinase; Provisional
 42-433 2.36e-14

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 74.86  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  42 APGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVK---THTLQLANTNPLYPDFSTSANNVQiDKTkplWHNyFLCGFK 118
Cdd:PTZ00290   42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKhfcDHKLRFATETDEHFVLDHLGGAKH-NKA---WTT-FVRGAA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 119 GIQ-EHFGLS----DLTGMNCLVDGNIPPSSGLSSSSAL-VCCAGLVTLTVLGM----------------NLSKVELAEI 176
Cdd:PTZ00290  117 TLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEELIEL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 177 cTKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIAHSCV--EMNKAAT 239
Cdd:PTZ00290  197 -AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIkhDLLGGTA 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 240 SHFNirvmecrlaakllakskslpwdkVLRLEEVQARLRVSLEEM----LLITEDALHPEPYSPEEVCSCLGISLQELrt 315
Cdd:PTZ00290  270 GMYN-----------------------TVRSDQEGAQKKIGKHRYrgkpFTFSDLVRNPKKYTFDGDVVAFMESCKPL-- 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 316 qiLSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEA----PDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVD-I 390
Cdd:PTZ00290  325 --MTPGE--------FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElI 394

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1333551220 391 CRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQR 433
Cdd:PTZ00290  395 NEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 42-414 9.34e-13

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 68.33  E-value: 9.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  42 APGRVNIIGEHID-YcGYSVLPMAVEQDMLIAVEPVKTHTLQLantnplYPDFSTSANNVQIDKTKPLwhNYFLCGFKGI 120
Cdd:COG1577     1 APGKLILFGEHAVvY-GQPAIAVAVDRRATVTVEPSDDDKLRI------ESPDLGGTLDLDPLADAAL--RYIKAAIEAA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 121 QEHFGLsDLTGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGMNLSKVELAEICTKSERYIGTEG 188
Cdd:COG1577    72 LEYLGL-PLKGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 189 GGMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIAHSCVemnKAATSHFnirvmecrlaakllakskslpwdkv 267
Cdd:COG1577   139 SGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKEL------------------------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 268 lrLEEVQARLRvsleemllitedalhpepyspeevcsclgislqelrtqilspnTQDVLIFKLYQRAKHVYSEAARVLQf 347
Cdd:COG1577   186 --VAKVRKLKE-------------------------------------------RNPELYEAFLEEIGDLVEEAIEALE- 219

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333551220 348 kkiceeapDNMVQLLGELMNQSHvscRDMYE--CSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIV 414
Cdd:COG1577   220 --------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLTGAGGGGCVIALA 277
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 329-413 3.96e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.10  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 329 KLYQRAKHVYSEAARVLQfkkiceeapDNMVQLLGELMNQSHVSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 408
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1333551220 409 CTVSI 413
Cdd:PTZ00298  288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 42-411 1.33e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 58.84  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220  42 APGRVNIIGEHIDYCGYSVLPMAVEQDM-LIAVEPVKTHTLQLANTNPLYPDFSTSANNVQIDKTKPLWhnYFLCGFkgi 120
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTtVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLS--RFSELN--- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 121 qehFGLSDLTgmnclVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICTKSERYIGTEGGGMDQSISflae 200
Cdd:TIGR00549  76 ---PPPLEIT-----IESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 201 eGTAKLIEFSPLRATDVKLPS-GAVFVIAHSCVEMNKAatshfnirvmecrlaakllakskslpwdkvlrleEVQARLRV 279
Cdd:TIGR00549 144 -TSGGPVYFEKGEGEFTKLISlDGYFVIADTGVSGSTK----------------------------------EAVARVRQ 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 280 SLEEmllitedalHPEpyspeevcsclgislqelrtqilspntqdvLIFKLYQRAKHVYSEAARVLQfkkiceeapDNMV 359
Cdd:TIGR00549 189 LLER---------FPE------------------------------LIDSIMDAIGELTLEAKAALQ---------DGDV 220

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333551220 360 QLLGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 411
Cdd:TIGR00549 221 ESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 352-432 9.17e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 52.47  E-value: 9.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 352 EEAPDNMVQLLGELMNQSHVSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSIVP-ADKLPSFLANVHE 428
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1333551220 429 AYYQ 432
Cdd:pfam08544  82 AGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 362-418 1.05e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.21  E-value: 1.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333551220 362 LGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADK 418
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 332-441 2.05e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 46.33  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551220 332 QRAKHVYSEAARVLQFKKICEEApDNMVQLL--------GELMNQSHVSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 402
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1333551220 403 GAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDRSLAPE 441
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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