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Conserved domains on  [gi|1331412678|ref|XP_023417006|]
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PR domain zinc finger protein 4 isoform X2 [Cavia porcellus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 407-539 1.28e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


:

Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.90  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 407 RARLSLPKQLVLRQSVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHGGVLEFCIITADENEC 486
Cdd:cd19189     1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1331412678 487 NWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMG 539
Cdd:cd19189    81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 367-404 6.20e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 91.97  E-value: 6.20e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1331412678 367 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDSPI 404
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-659 6.88e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.88e-06
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 634 NLRTHLKIHTGQKNYRCALCDKSFTQ 659
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
662-685 1.85e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....
gi 1331412678 662 HLESHMVIHTGEKNLKCDYCDKLF 685
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
690-715 1.58e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 690 DLKQHVLTHTQERQIKCPKCDKLFLR 715
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
610-630 5.99e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|.
gi 1331412678 610 HFMGHMGMKPHKCDFCSKAFS 630
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 407-539 1.28e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.90  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 407 RARLSLPKQLVLRQSVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHGGVLEFCIITADENEC 486
Cdd:cd19189     1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1331412678 487 NWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMG 539
Cdd:cd19189    81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 367-404 6.20e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 91.97  E-value: 6.20e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1331412678 367 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDSPI 404
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-659 6.88e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.88e-06
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 634 NLRTHLKIHTGQKNYRCALCDKSFTQ 659
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 428-535 1.09e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 42.71  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678  428 GVWTSETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVNH-IWKIYhggvLEFCIITADENecNWMMFVRRARNREEQ 501
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFyLFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1331412678  502 NL-VAYPHDGKIYFCTSQDIPPENELLFYYSRDYA 535
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
662-685 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....
gi 1331412678 662 HLESHMVIHTGEKNLKCDYCDKLF 685
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
618-707 4.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 618 KPHKCDFCSKAFSDPSNLRTHLKIHTGQ-KNYRCALCDKSFTQKAHLESHM--VIHTGEKNLKCD----YCDKLFMRRQD 690
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFScpysLCGKLFSRNDA 338

                          90
                  ....*....|....*..
gi 1331412678 691 LKQHVLTHTQERQIKCP 707
Cdd:COG5048   339 LKRHILLHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
690-715 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 690 DLKQHVLTHTQERQIKCPKCDKLFLR 715
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 428-530 5.57e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.50  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 428 GVWTSETIPVRTCFG-----PLIGQQSHSMEVAEWTDKAVNHIWKIYH---GGVLEFCIITADENECNWMMFVRRARNRE 499
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSCDPN 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1331412678 500 -EQNLVAYPHDGKIYFCTSQDIPPENELLFYY 530
Cdd:pfam00856  83 cEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
610-630 5.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|.
gi 1331412678 610 HFMGHMGMKPHKCDFCSKAFS 630
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 407-539 1.28e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.90  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 407 RARLSLPKQLVLRQSVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHGGVLEFCIITADENEC 486
Cdd:cd19189     1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1331412678 487 NWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMG 539
Cdd:cd19189    81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 407-539 2.32e-34

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 127.47  E-value: 2.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 407 RARLSLPKQLVLRQsVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEwtdkavNHIwkiyHGGVLE------FCIIT 480
Cdd:cd19194     1 RARASLPLILQIFR-FGETLGGVFAKRRIPKRTQFGPLEGPLVKKSELKD------NKI----HPLELEeddgedLYFDL 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1331412678 481 ADENECNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMG 539
Cdd:cd19194    70 SDENKCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 411-536 6.01e-34

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 126.29  E-value: 6.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 411 SLPKQLVLRQSVVGADV-GVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKavNHIWKIYHGGVLEFCIITADENECNWM 489
Cdd:cd19187     2 SLPRNLTLKYSSVGREVlGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANR--KYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1331412678 490 MFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQ 536
Cdd:cd19187    80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFAR 126
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 406-538 4.05e-32

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 120.98  E-value: 4.05e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 406 SRARLSLPKQLVLRQSVVGADvGVWTSETIPVRTCFGPLIGQqshsmEVAEWTDKAVNHIwKIYHGGVLEFCIITADENE 485
Cdd:cd19199     1 SRARSSLPDNLEIRQLEDGSE-GVFALVPLVKRTQFGPFEAK-----RVARLDGFAVFPL-KVFEKDGSVVYLDTSNEDD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1331412678 486 CNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQM 538
Cdd:cd19199    74 CNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 412-531 2.72e-31

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 116.91  E-value: 2.72e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 412 LPKQLVLRQS-VVGADVGVWTSETIPVRTCFGPLIGQQshsmevaewtdkavnhiwkiyhggvlefciitadenecNWMM 490
Cdd:cd10534     1 LPAGLELVLSsIPEGGLGVFARRTIPAGTRFGPLEGVV--------------------------------------NWMR 42

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1331412678 491 FVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYS 531
Cdd:cd10534    43 FVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 409-539 2.24e-30

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 116.18  E-value: 2.24e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 409 RLSLPKQLVLRQS-VVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEwtdkaVNHIWKIYHGGVLEFCIITADENECN 487
Cdd:cd19193     1 RLTLPPGLSIKRSsIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEAAD-----SGYSWQIYKGGKLSHYIDAKDESKSN 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1331412678 488 WMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMG 539
Cdd:cd19193    76 WMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 412-541 5.26e-25

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 100.89  E-value: 5.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 412 LPKQLVLRQSVV-GADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKavNHIWKIY--HGGVLEFcIITADENECNW 488
Cdd:cd19196     1 LPSQVIIAQSSIpGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNN--NLMWEVFneDGTVSHF-IDASQENHRSW 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1331412678 489 MMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMGVP 541
Cdd:cd19196    78 MTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 410-541 7.14e-24

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 97.85  E-value: 7.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 410 LSLPKQLVLRQSVVGADV--GVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKAvnHIWKIYHGGVLEFCIITADENEcN 487
Cdd:cd19198     1 LDLPEGLRVLQTSFGGTPhyGVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNS--FMWEIFEDGKLSHFIDGRGSTG-N 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1331412678 488 WMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQMGVP 541
Cdd:cd19198    78 WMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIP 131
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 367-404 6.20e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 91.97  E-value: 6.20e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1331412678 367 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDSPI 404
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 412-530 4.85e-20

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 86.34  E-value: 4.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 412 LPKQLVLRQSVV-GADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTdkavnHIWKIYHGGVLEFCIITADENECNWMM 490
Cdd:cd19188     4 LPEELELKPSAVdKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV-----YMWEIYGPKRGWMCVDASDPTKGNWLR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1331412678 491 FVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYY 530
Cdd:cd19188    79 YVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 412-538 1.13e-18

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 82.91  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 412 LPKQLVL-RQSVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAewtdKAVN---HIWKIYHG-GVLEFCIITADENEC 486
Cdd:cd19191     1 LPDEVCLcTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQI----GAVRntqHLWEIYDQeGTLQHFIDGGDPSKS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1331412678 487 NWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQM 538
Cdd:cd19191    77 SWMRYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 410-529 2.77e-18

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 81.64  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 410 LSLPKQLVLRQS-VVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAewtdkavNHIWKIY-HGGVLEFCIitaDENEC- 486
Cdd:cd19200     8 IPIPPDFELRESaAVGAGLGVWTKVRIEVGEKFGPFVGVQRSSVKDP-------TYAWEIVdEFGKVKFWI---DASEPg 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1331412678 487 --NWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFY 529
Cdd:cd19200    78 tgNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLY 122
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 410-527 9.42e-18

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 79.70  E-value: 9.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 410 LSLPKQLVLRQ--SVVGADVGVWTSETIPVRTCFGPL---IGQQSHSMEVaEWTDKAVnhiwkiyhGGVLEFCIITADEN 484
Cdd:cd19201     1 LSLPGELELRKpsQDAGRSGGVWAKQPLPEGTRFGPYpgkLVKEPLDPSY-EWKVEAQ--------GSKGGEGLLLLTED 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1331412678 485 ECNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELL 527
Cdd:cd19201    72 SGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELI 114
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 391-542 7.60e-16

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 75.75  E-value: 7.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 391 PDHGPVTFVPDSPIesrarlslPKQLVLRQS-VVGADVGVWTSETIPVRTCFGPLIGQQSHSMevaewtdKAVNHIWKIY 469
Cdd:cd19214    17 PYKAPIYIPDDIPI--------PSEFELRESnIPGTGLGIWTKRKIEVGEKFGPYVGEQRSNL-------KDPSYGWEVL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1331412678 470 --HGGVlEFCIITADENECNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELL-FYYSRDYAQQMGVPE 542
Cdd:cd19214    82 deFGNV-KFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLlFMKSEDYSHETMAPD 156
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 428-535 4.20e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 69.77  E-value: 4.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 428 GVWTSETIPVRTCFGPLIGQ-QSH---SMEVAEWTDKAVnhiwKIYHGGVlefciITADENEC----NWMMFVRRARNRE 499
Cdd:cd19192    21 SVVTTTDIPAGTIFGPCVLSfTLGydiADIALKTTDKRV----VPYIFRV-----DTGACNGSsepsDWLRLVQPARDRH 91

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1331412678 500 EQNLVAY-PHDGKIYFCTSQDIPPENELLFYYSRDYA 535
Cdd:cd19192    92 EQNLEAFrKNEGQVYFRTLRRIRKGEELLVWYSDELA 128
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 391-529 3.54e-12

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 65.28  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 391 PDHGPVTFVPDSPIesrarlslPKQLVLRQSVV-GADVGVWTSETIPVRTCFGPLIGQQSHSMEVAE--WTDKAVNH--- 464
Cdd:cd19213     7 PYEAPVYIPDDIPI--------PSDFELRESSIpGAGLGVWAKRKIEAGERFGPYTGVQRSTLKDTNfgWEQILNDVevs 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1331412678 465 -----IWKIYHG-GVLEFCIITADENECNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFY 529
Cdd:cd19213    79 sqegcITKIVDDlGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 408-538 9.91e-12

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 62.95  E-value: 9.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 408 ARLSLPKQLVLRQSVVGADVGVWTSETIPVRTCFGPLIGQ---QSHSMEVAEWTDKAVNHIWKIYHGgvlefciitADEN 484
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQictQDKSSGFFSWLIVDKNNRYKSIDG---------SDET 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1331412678 485 ECNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQM 538
Cdd:cd19195    72 KANWMRYVVISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 412-530 6.31e-10

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 57.69  E-value: 6.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 412 LPKQLVLRQSVVGADVGVWTSETIPVRTCFGPLIGQQSHSMEVAEWTDKAVnhIWKIY--HGGVLeFCIITADENECNWM 489
Cdd:cd19190     5 VPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRL--MWEVRgsKGEVL-YILDASNPRHSNWL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1331412678 490 MFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYY 530
Cdd:cd19190    82 RFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 470-538 1.15e-09

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 56.37  E-value: 1.15e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1331412678 470 HGGVLEFCIITADENECNWMMFVRRARNREEQNLVAY--PHDGKIYFCTSQDIPPENELLFYYSRDYAQQM 538
Cdd:cd19197    33 RRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIadLPGGQIFYRALRDIQPGEELTVWYSNSLAQWF 103
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 411-527 2.61e-07

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 50.11  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 411 SLPKQLVLRQSVV-GADVGVWTSET-IPVRTCFGPLIGQqshsmevAEWTDK--AVNHiwkiyHGGVLEFCIIT-ADENE 485
Cdd:cd10520     4 SLPPGLALGPSLAqEERLGVWCVGDaLQKGTFLGPLEEE-------LESHDLteGGSP-----RQEESGQSGDVlACEQS 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1331412678 486 CNWMMFVRRARNREEQNLVAYPHDGKIYFCTSQDIPPENELL 527
Cdd:cd10520    72 SKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELL 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-659 6.88e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.88e-06
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 634 NLRTHLKIHTGQKNYRCALCDKSFTQ 659
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 428-535 1.09e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 42.71  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678  428 GVWTSETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVNH-IWKIYhggvLEFCIITADENecNWMMFVRRARNREEQ 501
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFyLFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1331412678  502 NL-VAYPHDGKIYFCTSQDIPPENELLFYYSRDYA 535
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
662-685 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....
gi 1331412678 662 HLESHMVIHTGEKNLKCDYCDKLF 685
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
618-707 4.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 618 KPHKCDFCSKAFSDPSNLRTHLKIHTGQ-KNYRCALCDKSFTQKAHLESHM--VIHTGEKNLKCD----YCDKLFMRRQD 690
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFScpysLCGKLFSRNDA 338

                          90
                  ....*....|....*..
gi 1331412678 691 LKQHVLTHTQERQIKCP 707
Cdd:COG5048   339 LKRHILLHTSISPAKEK 355
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 648-670 8.05e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.05e-04
                          10        20
                  ....*....|....*....|...
gi 1331412678 648 YRCALCDKSFTQKAHLESHMVIH 670
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
690-715 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1331412678 690 DLKQHVLTHTQERQIKCPKCDKLFLR 715
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
615-735 4.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 615 MGMKPHKCDF--CSKAFSDPSNLRTHLKIHTGQKNYRCAL--CDKSFTQKAHLESH--MVIHTGEKNLK---CDY--CDK 683
Cdd:COG5048   317 ESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPqsLQQYKDLKNDKkseTLSnsCIR 396

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1331412678 684 LFMRRQDLKQHVLTHT--QERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCE 735
Cdd:COG5048   397 NFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
625-712 5.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 625 CSKAFSDPSNlRTHLKIHTGQKNYRCALCDKSFTQKAHLESHMVIHTGEKNLKCDY--CDKLFMRRQDLKQHVLTHTQER 702
Cdd:COG5048    12 NNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90

                          90
                  ....*....|
gi 1331412678 703 QIKCPKCDKL 712
Cdd:COG5048    91 SDLNSKSLPL 100
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 428-530 5.57e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.50  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 428 GVWTSETIPVRTCFG-----PLIGQQSHSMEVAEWTDKAVNHIWKIYH---GGVLEFCIITADENECNWMMFVRRARNRE 499
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSCDPN 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1331412678 500 -EQNLVAYPHDGKIYFCTSQDIPPENELLFYY 530
Cdd:pfam00856  83 cEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
610-630 5.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|.
gi 1331412678 610 HFMGHMGMKPHKCDFCSKAFS 630
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
592-709 7.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331412678 592 WKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDF--CSKAFSDPSNLRTHLKIHTGQKNYRC-ALCDKSFTQKAHLESHMV 668
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1331412678 669 IHTGEKNLKCDYCDKLFMRRQDLKQHVLTHTQERQIKCPKC 709
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
620-644 9.91e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 9.91e-03
                          10        20
                  ....*....|....*....|....*
gi 1331412678 620 HKCDFCSKAFSDPSNLRTHLKIHTG 644
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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