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Conserved domains on  [gi|1788891958|ref|XP_023354413|]
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GPI mannosyltransferase 3 isoform X2 [Sarcophilus harrisii]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 52-494 4.07e-115

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member PLN02816:

Pssm-ID: 473917  Cd Length: 546  Bit Score: 350.10  E-value: 4.07e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958  52 LVLFTIFLRILNCFLVQTSFVPDEYWQSLEVAHHMVFNYGYLTWEWAEGLRGFSYPLIFASIYKILYLFTKDSVQLLIWV 131
Cdd:PLN02816   41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 132 PRLAQALLSAVADVKLYSLVRQLENQEVAKWVFFCQLCSWFTWYCCTRTLTNSMETVLTTFALFYYPLEGSKS----VNS 207
Cdd:PLN02816  121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypVNR 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 208 FMYSSLVALAFIIRPTAVIPWMPLLFRHFWQEQKKFDLVLQHFIPVGLVTLGFSLIIDRIFFGQWTFVQLNFLKFNVLKN 287
Cdd:PLN02816  201 KWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 288 LGKFYGSHPWHWYICQGFPVILGPHLPFFIHGCFLTvrRYQILLVAIVWTVLVYSLLSHKEFRFIYPILPFCMVFCGHSL 367
Cdd:PLN02816  281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 368 -----------------------NHLKTWKKPALS--FLFLSNVMLALYTGLIHQRGSLDVMTHiqeLCDDSPNQSSASV 422
Cdd:PLN02816  359 aqmevsgssssssvtkkkqvprqNHTKWSPKLRLSvyFLLATNIPMALYMSLFHQRGTEDAMNY---LSDEAYKGRVKSI 435

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788891958 423 FVMMPCHSTPYYSHVHCPLPMRFLQCPPdlNGKENYLDEADKFYLNPLSWLNQEFSNNTLLPTHLIIFSVLE 494
Cdd:PLN02816  436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEE 505
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 52-494 4.07e-115

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 350.10  E-value: 4.07e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958  52 LVLFTIFLRILNCFLVQTSFVPDEYWQSLEVAHHMVFNYGYLTWEWAEGLRGFSYPLIFASIYKILYLFTKDSVQLLIWV 131
Cdd:PLN02816   41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 132 PRLAQALLSAVADVKLYSLVRQLENQEVAKWVFFCQLCSWFTWYCCTRTLTNSMETVLTTFALFYYPLEGSKS----VNS 207
Cdd:PLN02816  121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypVNR 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 208 FMYSSLVALAFIIRPTAVIPWMPLLFRHFWQEQKKFDLVLQHFIPVGLVTLGFSLIIDRIFFGQWTFVQLNFLKFNVLKN 287
Cdd:PLN02816  201 KWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 288 LGKFYGSHPWHWYICQGFPVILGPHLPFFIHGCFLTvrRYQILLVAIVWTVLVYSLLSHKEFRFIYPILPFCMVFCGHSL 367
Cdd:PLN02816  281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 368 -----------------------NHLKTWKKPALS--FLFLSNVMLALYTGLIHQRGSLDVMTHiqeLCDDSPNQSSASV 422
Cdd:PLN02816  359 aqmevsgssssssvtkkkqvprqNHTKWSPKLRLSvyFLLATNIPMALYMSLFHQRGTEDAMNY---LSDEAYKGRVKSI 435

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788891958 423 FVMMPCHSTPYYSHVHCPLPMRFLQCPPdlNGKENYLDEADKFYLNPLSWLNQEFSNNTLLPTHLIIFSVLE 494
Cdd:PLN02816  436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEE 505
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-438 6.18e-113

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 340.11  E-value: 6.18e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958  51 YLVLFTIFLRILNCFLVQTSfVPDEYWQSLEVAHHMVFNYGYLTWEWA--EGLRGFSYPLIFASIYKILYLFTKDSVQLL 128
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSpkYGIRSYLYPLLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 129 IWVPRLAQALLSAVADVKLYSLVRQLENQEVAKWVFFCQLCSWFTWYCCTRTLTNSMETVLTTFALFYYPLEGSKSV--- 205
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 206 -NSFMYSSLVALAFIIRPTAVIPWMPLLFRHFWQEQKKF-DLVLQHFIPVGLVTLGF----SLIIDRIFFGQWTFVQLNF 279
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKRlKLFLFLAISLGLLVALLvlgaVILIDSYFYGRFVFTPLNF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 280 LKFNVLKNLGKFYGSHPWHWYICQGFPVILGPHLPFFIHGCFLTVRRY----QILLVAIVWTVLVYSLLSHKEFRFIYPI 355
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKvsrlSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 356 LPFCMVFCGH-----SLNHLKTWKKPALSFLFL-SNVMLALYTGLIHQRGSL----DVMTHIQELC--DDSPNQSSASVF 423
Cdd:pfam03901 320 YPLILLSAAIaltrlSRRSWKVRKKLSLLFLLLfFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399

                         410
                  ....*....|....*
gi 1788891958 424 VMMPCHSTPYYSHVH 438
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 52-494 4.07e-115

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 350.10  E-value: 4.07e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958  52 LVLFTIFLRILNCFLVQTSFVPDEYWQSLEVAHHMVFNYGYLTWEWAEGLRGFSYPLIFASIYKILYLFTKDSVQLLIWV 131
Cdd:PLN02816   41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 132 PRLAQALLSAVADVKLYSLVRQLENQEVAKWVFFCQLCSWFTWYCCTRTLTNSMETVLTTFALFYYPLEGSKS----VNS 207
Cdd:PLN02816  121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypVNR 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 208 FMYSSLVALAFIIRPTAVIPWMPLLFRHFWQEQKKFDLVLQHFIPVGLVTLGFSLIIDRIFFGQWTFVQLNFLKFNVLKN 287
Cdd:PLN02816  201 KWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 288 LGKFYGSHPWHWYICQGFPVILGPHLPFFIHGCFLTvrRYQILLVAIVWTVLVYSLLSHKEFRFIYPILPFCMVFCGHSL 367
Cdd:PLN02816  281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 368 -----------------------NHLKTWKKPALS--FLFLSNVMLALYTGLIHQRGSLDVMTHiqeLCDDSPNQSSASV 422
Cdd:PLN02816  359 aqmevsgssssssvtkkkqvprqNHTKWSPKLRLSvyFLLATNIPMALYMSLFHQRGTEDAMNY---LSDEAYKGRVKSI 435

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788891958 423 FVMMPCHSTPYYSHVHCPLPMRFLQCPPdlNGKENYLDEADKFYLNPLSWLNQEFSNNTLLPTHLIIFSVLE 494
Cdd:PLN02816  436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEE 505
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-438 6.18e-113

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 340.11  E-value: 6.18e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958  51 YLVLFTIFLRILNCFLVQTSfVPDEYWQSLEVAHHMVFNYGYLTWEWA--EGLRGFSYPLIFASIYKILYLFTKDSVQLL 128
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSpkYGIRSYLYPLLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 129 IWVPRLAQALLSAVADVKLYSLVRQLENQEVAKWVFFCQLCSWFTWYCCTRTLTNSMETVLTTFALFYYPLEGSKSV--- 205
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 206 -NSFMYSSLVALAFIIRPTAVIPWMPLLFRHFWQEQKKF-DLVLQHFIPVGLVTLGF----SLIIDRIFFGQWTFVQLNF 279
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKRlKLFLFLAISLGLLVALLvlgaVILIDSYFYGRFVFTPLNF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 280 LKFNVLKNLGKFYGSHPWHWYICQGFPVILGPHLPFFIHGCFLTVRRY----QILLVAIVWTVLVYSLLSHKEFRFIYPI 355
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKvsrlSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788891958 356 LPFCMVFCGH-----SLNHLKTWKKPALSFLFL-SNVMLALYTGLIHQRGSL----DVMTHIQELC--DDSPNQSSASVF 423
Cdd:pfam03901 320 YPLILLSAAIaltrlSRRSWKVRKKLSLLFLLLfFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399

                         410
                  ....*....|....*
gi 1788891958 424 VMMPCHSTPYYSHVH 438
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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