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Conserved domains on  [gi|1308441685|ref|XP_023141841|]
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density-regulated protein isoform X4 [Amphiprion ocellaris]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 10795723)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 27-191 2.19e-76

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


:

Pssm-ID: 273472  Cd Length: 173  Bit Score: 226.68  E-value: 2.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685  27 PLKVLYCGVCSLPTEYCEYMPEPAKCRQWLEKNFPDVFARMTVANAPKQEPGTGDAPPA----GEEEEKKKQKRGGRGQI 102
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAqeekGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 103 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASV----TAEDEIIIQGDFTDDIIDVIQE 178
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 1308441685 179 KWPEVDDDSIDDL 191
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 27-191 2.19e-76

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 226.68  E-value: 2.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685  27 PLKVLYCGVCSLPTEYCEYMPEPAKCRQWLEKNFPDVFARMTVANAPKQEPGTGDAPPA----GEEEEKKKQKRGGRGQI 102
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAqeekGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 103 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASV----TAEDEIIIQGDFTDDIIDVIQE 178
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 1308441685 179 KWPEVDDDSIDDL 191
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 111-192 4.78e-41

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 133.84  E-value: 4.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 111 QKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTA----EDEIIIQGDFTDDIIDVIQEKWPEVDDD 186
Cdd:cd11607     1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKgaegKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                  ....*.
gi 1308441685 187 SIDDLG 192
Cdd:cd11607    81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
110-179 6.49e-17

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 71.70  E-value: 6.49e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308441685 110 PQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVT---AEDEIIIQGDFTDDIIDVIQEK 179
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVkdgGGEEIQVQGDQRDKVAELLTEK 73
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 106-179 9.92e-04

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 37.49  E-value: 9.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308441685 106 KKTVPQKVTIAKIPRAKK----KYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVtAEDEIIIQGDFTDDIIDVIQEK 179
Cdd:COG0023    27 AEELPPGDGIVRVRRETKgrkgKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTV-KDGEIEIQGDHRDKIKALLEKK 103
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
111-179 3.07e-03

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 35.67  E-value: 3.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1308441685 111 QKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTaEDEIIIQGDFTDDIIDVIQEK 179
Cdd:PRK00939   24 QRIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTVK-DGRIELQGDHRERVKELLIKM 91
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 27-191 2.19e-76

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 226.68  E-value: 2.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685  27 PLKVLYCGVCSLPTEYCEYMPEPAKCRQWLEKNFPDVFARMTVANAPKQEPGTGDAPPA----GEEEEKKKQKRGGRGQI 102
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAqeekGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 103 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASV----TAEDEIIIQGDFTDDIIDVIQE 178
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 1308441685 179 KWPEVDDDSIDDL 191
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 111-192 4.78e-41

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 133.84  E-value: 4.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 111 QKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTA----EDEIIIQGDFTDDIIDVIQEKWPEVDDD 186
Cdd:cd11607     1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKgaegKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                  ....*.
gi 1308441685 187 SIDDLG 192
Cdd:cd11607    81 NIEILG 86
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 112-184 5.39e-25

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 92.49  E-value: 5.39e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308441685 112 KVTIAKIPRAKKKYVTRVCGLATFdIDLKEAQRFFAQKFSCGASVTAE-DEIIIQGDFTDDIIDVIQEKWPEVD 184
Cdd:cd00474     1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVEGEkMEIEIQGDHTDQIIVALEEKGIDKD 73
SUI1 pfam01253
Translation initiation factor SUI1;
110-179 6.49e-17

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 71.70  E-value: 6.49e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308441685 110 PQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVT---AEDEIIIQGDFTDDIIDVIQEK 179
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVkdgGGEEIQVQGDQRDKVAELLTEK 73
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 110-180 7.57e-08

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 47.94  E-value: 7.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308441685 110 PQKVTIAKipRAKKKYVTRVCGLATFDIDLKEaqrfFA----QKFSCGASVT------AEDEIIIQGDFTDDIIDVIQEK 179
Cdd:cd11608     1 PIDITTER--RQGNKKVTLISGLESFGIDPEE----FAkelqKKCAASTSVSplpgkkKGVEVQVQGNQVKFVAKLLTEK 74


                  .
gi 1308441685 180 W 180
Cdd:cd11608    75 Y 75
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 122-179 1.95e-06

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 44.01  E-value: 1.95e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1308441685 122 KKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVtAEDEIIIQGDFTDDIIDVIQEK 179
Cdd:cd11567    13 GGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTV-KDGEIELQGDHREKIKELLEKK 69
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 120-167 1.59e-04

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 39.06  E-value: 1.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1308441685 120 RAKKKYVTRVCGLATfDIDLKEAQRFFAQKFSCGASVTAEDE----IIIQGD 167
Cdd:cd11566    10 RNGRKTLTTVQGLPE-EFDLKKILKAFKKEFACNGTVVEDPEygevIQLQGD 60
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 106-179 9.92e-04

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 37.49  E-value: 9.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308441685 106 KKTVPQKVTIAKIPRAKK----KYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVtAEDEIIIQGDFTDDIIDVIQEK 179
Cdd:COG0023    27 AEELPPGDGIVRVRRETKgrkgKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTV-KDGEIEIQGDHRDKIKALLEKK 103
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
111-179 3.07e-03

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 35.67  E-value: 3.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1308441685 111 QKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTaEDEIIIQGDFTDDIIDVIQEK 179
Cdd:PRK00939   24 QRIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTVK-DGRIELQGDHRERVKELLIKM 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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