|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
344-1308 |
1.13e-152 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 479.44 E-value: 1.13e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 344 HELVPDMALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGK 423
Cdd:COG4581 12 LEALADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVER 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 424 F---DVGLLTGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLS 500
Cdd:COG4581 92 FgaeNVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 501 ATVPNTIEFADWIGRtkqkrihVTGTT------KRPVPLEHcifysgesykiceneiflshglkaakdaskkktsSVASG 574
Cdd:COG4581 172 ATVGNAEEFAEWLTR-------VRGETavvvseERPVPLEF----------------------------------HYLVT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 575 SHVgasasndgarnrknesFNRIKQNKhsgsqnlgnfsgtswgnqkngdsqnnwgsRRSDASSWLLLINKLSKRSLLPVV 654
Cdd:COG4581 211 PRL----------------FPLFRVNP-----------------------------ELLRPPSRHEVIEELDRGGLLPAI 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 655 IFCFSKNRCDKSADSIYSIDLTSSSEKSEIRVFCDKAfsrlkGSDRTLPQIVRVQGLLHRGIGVHHAGLLPIVKEVVEML 734
Cdd:COG4581 246 VFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEEL 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 735 FCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIGTVIVMcrdkIPEEKDLK 814
Cdd:COG4581 321 FQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDTEGHVVVL----APEHDDPK 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 815 RV--IVGSAT-KLESQFRLTYIMILHLL-RVEELKVEDMLKRSFAEFHA---QKKLPEKQQLLMRKLAQPTRTVECIKGE 887
Cdd:COG4581 397 KFarLASARPePLRSSFRPSYNMVLNLLaRPGLERARELLEDSFAQFQAdrsVVGLARRARELERALAGVVERLACDLGD 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 888 paIEEYYDLY---AEAEKNSNQVSEAVMQssaiqqfltpgrVVVVKSQSDKDHLlsVIVKALPMASRQYIVLVLKpdspp 964
Cdd:COG4581 477 --LQEYFALRqplSPLEALERESPAYALD------------VVSVPEATLEDPR--PVLLAQDRRARGEAAAAMK----- 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 965 vqssssddsvkkkedfpqgyfmvpkskrglendyyspstrkgsgvvnirlphagaaAGVSYEVRgvdakefvcvcnkkiq 1044
Cdd:COG4581 536 --------------------------------------------------------AAIEYDER---------------- 543
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 1045 lnpgrlLEDVNNVAYSQtvqqlldiksdgkfPpaldplkdlklkdvnlveaykgwtglvlkmvankCHGCiKLGEHLKLA 1124
Cdd:COG4581 544 ------MERLEEVLRPH--------------P----------------------------------LHEC-PLERAFELY 568
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 1125 AEIKKHKEEVNnlkfQMSDEALQQMPDFqgrIDVLKEIGCInADLVVQIKGRVACEMNSgeeliCTECLFENQLDDLEPE 1204
Cdd:COG4581 569 RETHPWVRDIE----LRPKSVARDFDRF---CELLREYGYL-DDLTLTSEGLLLRYLYD-----AAEALRQGVPDDLDPE 635
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 1205 EAVALMSAFVFQQR----NTSEPSLTPKLSMAKKRLYETAIRLGKLQAQFRLPVdceeyardnLKFGLVEvvyEWAKGTP 1280
Cdd:COG4581 636 ELAALISWLVEEVRrvdsSEWERLPSPANRRAFVLVNALFRRLELLERRHGLPE---------LDPGLAG---AWASGAD 703
|
970 980 990
....*....|....*....|....*....|....*
gi 1279791228 1281 FADICELTDVPEGMIVRTIVR-------LDETCRE 1308
Cdd:COG4581 704 LAEVLDATDLDAGDFVRWVRQvidpdpeLRRTARA 738
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
351-527 |
3.78e-106 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 333.08 E-value: 3.78e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 351 ALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKF-DVGLL 429
Cdd:cd18027 2 AFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFgDVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 430 TGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTIEF 509
Cdd:cd18027 82 TGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVEF 161
|
170
....*....|....*...
gi 1279791228 510 ADWIGRTKQKRIHVTGTT 527
Cdd:cd18027 162 ADWIGRIKKKNIYVISTP 179
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
349-529 |
1.42e-89 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 288.57 E-value: 1.42e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 349 DMALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKF-DVG 427
Cdd:cd18024 24 NPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELQEEFgDVG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 428 LLTGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTI 507
Cdd:cd18024 104 LMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKVRYVFLSATIPNAR 183
|
170 180
....*....|....*....|..
gi 1279791228 508 EFADWIGRTKQKRIHVTGTTKR 529
Cdd:cd18024 184 QFAEWICKIHKQPCHVVYTDYR 205
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
345-866 |
1.05e-69 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 244.03 E-value: 1.05e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 345 ELVPDMALDF-----PFELDTFQKEAI-YHLEKGDSVFVAAHTSAGKTVVAEYAF--ALATKHctRAVYTAPIKTISNQK 416
Cdd:COG1204 5 ELPLEKVIEFlkergIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAIlkALLNGG--KALYIVPLRALASEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 417 YRDFCGKF-----DVGLLTGDVSLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVI 487
Cdd:COG1204 83 YREFKRDFeelgiKVGVSTGDYDSDDEwlgrYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEVLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 488 ---IMLPRHINIVLLSATVPNTIEFADWIGRTkqkrihVTGTTKRPVPLEHCIFYSGESYkiceneiFlshglkaakdas 564
Cdd:COG1204 163 arlRRLNPEAQIVALSATIGNAEEIAEWLDAE------LVKSDWRPVPLNEGVLYDGVLR-------F------------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 565 kkktssvasgshvgasasNDGARNRKNESFNRIKQNKHSGSQNLgNFSgtswgnqkngdsqnnwgSRRSDASSWLLLINK 644
Cdd:COG1204 218 ------------------DDGSRRSKDPTLALALDLLEEGGQVL-VFV-----------------SSRRDAESLAKKLAD 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 645 LSKRSLLPVvifcfSKNRCDKSADSIYSIDLTSSSEKSEIRvfcdkafsrlkgsdrtlpqivrvqgLLHRGIGVHHAGLL 724
Cdd:COG1204 262 ELKRRLTPE-----EREELEELAEELLEVSEETHTNEKLAD-------------------------CLEKGVAFHHAGLP 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 725 PIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRqllPGEYTQMAGRAGRRGLDKIGTVIVMCR 804
Cdd:COG1204 312 SELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMVPIP---VLEFKQMAGRAGRPGYDPYGEAILVAK 388
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1279791228 805 DKIPEEKDLKRVIVGSATKLESQFRLTYIMILHLLRV-------EELKVEDMLKRSFAEFHAQKKLPEK 866
Cdd:COG1204 389 SSDEADELFERYILGEPEPIRSKLANESALRTHLLALiasgfanSREELLDFLENTFYAYQYDKGDLEE 457
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
1169-1337 |
1.63e-64 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 215.39 E-value: 1.63e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 1169 LVVQIKGRVACEMNSGEELICTECLFENQLDDLEPEEAVALMSAFVFQQRNTSEPSLTPKLSMAKKRLYETAirlgklqa 1248
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSPELAEALRLLEEIA-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 1249 qFRLPVDCEeyardnLKFGLVEVVYEWAKGTPFADICELTDVPEGMIVRTIVRLDETCREFKNAAAIMGNSALHKKMETA 1328
Cdd:pfam08148 73 -HRIAVSRF------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*....
gi 1279791228 1329 SNAIKRDIV 1337
Cdd:pfam08148 146 IELIKRDIV 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
357-516 |
3.30e-54 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 187.08 E-value: 3.30e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 357 ELDTFQKEAIYHL-EKGDSVFVAAHTSAGKTVVAEYA-FALATKHCTRAVYTAPIKTISNQKYRDFCGKF-----DVGLL 429
Cdd:cd17921 1 LLNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAiLRALATSGGKAVYIAPTRALVNQKEADLRERFgplgkNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 430 TGDVSLR----PEASCLIMTTEILRSMLYRGAD-IIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPR---HINIVLLSA 501
Cdd:cd17921 81 TGDPSVNklllAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLRinkNARFVGLSA 160
|
170
....*....|....*
gi 1279791228 502 TVPNTIEFADWIGRT 516
Cdd:cd17921 161 TLPNAEDLAEWLGVE 175
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
639-804 |
4.50e-47 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 165.42 E-value: 4.50e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 639 LLLINKLSKRSLLPVVIFCFSKNRCDKSADSIysidltsssekseirvfcdkafsrlkgsdrtlpqivrvqgllhRGIGV 718
Cdd:cd18795 32 IVLLKIETVSEGKPVLVFCSSRKECEKTAKDL-------------------------------------------AGIAF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 719 HHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIGT 798
Cdd:cd18795 69 HHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGE 148
|
....*.
gi 1279791228 799 VIVMCR 804
Cdd:cd18795 149 AIIMTK 154
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
847-1143 |
3.37e-46 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 167.46 E-value: 3.37e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 847 EDMLKRSFAEFHAQKKLPEKQQLLmRKLAQPTRTVEcIKGEPAIEEYYDLYAEAEKNSNQVSEAVMQSSAIQQFLTPGRV 926
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKL-KELEKELASIK-IPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 927 VVVKSQSDKDHLLSVIVK--------ALPMASRQYIV---LVLKPDSPPVQSSssddsvKKKEDFPQGYFMVPKSKRGle 995
Cdd:pfam13234 79 VVVKDNGDQDFGWGVVVNfkkrkkngKAEPPQESYIVdvlLVLALVSSPEDLD------KFNDVNPEGFRPAPPGEKG-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 996 ndyyspstrkgsgvvnirlphagaaagvSYEVRGVDAKEFVCVCNKKIQLnPGRLLEDVNNVAYSQTVQQLLDIKSDGkf 1075
Cdd:pfam13234 151 ----------------------------EMEVVPVPLSDIEAISSVRLKL-PKDLRPAEAREAVLKALQELKRRFPDG-- 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1279791228 1076 PPALDPLKDLKLKDVNLVEAYKGWTGLVLKMVANKCHGCIKLGEHLKLAAEIKKHKEEVNNLKFQMSD 1143
Cdd:pfam13234 200 IPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHKSPRLEELYALYHEKVELQEEIKELKKEISD 267
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
362-805 |
5.84e-32 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 134.70 E-value: 5.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIyhlEKG----DSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGK----FDVGLLTGDV 433
Cdd:PRK02362 28 QAEAV---EAGlldgKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEEFERFeelgVRVGISTGDY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 434 SLRPEA----SCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHIN----IVLLSATVPN 505
Cdd:PRK02362 105 DSRDEWlgdnDIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKL-RRLNpdlqVVALSATIGN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 506 TIEFADWIGRTKqkrihVTgTTKRPVPLEHCIFYSGE-SYKICENEIflshglkaakdaskkktssvasgshvgasasnd 584
Cdd:PRK02362 184 ADELADWLDAEL-----VD-SEWRPIDLREGVFYGGAiHFDDSQREV--------------------------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 585 gARNRKNESFNRIKQNKHSGSQNLGNFSgtswgnqkngdsqnnwgSRRSDASswlllinklskrsllpvvifcFSKNRCD 664
Cdd:PRK02362 225 -EVPSKDDTLNLVLDTLEEGGQCLVFVS-----------------SRRNAEG---------------------FAKRAAS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 665 KSADSIYSIDLTSSSE-KSEIRvfcdkafsrlKGSDR----TLPQIVRvqgllhRGIGVHHAGLLPIVKEVVEMLFCRGV 739
Cdd:PRK02362 266 ALKKTLTAAERAELAElAEEIR----------EVSDTetskDLADCVA------KGAAFHHAGLSREHRELVEDAFRDRL 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279791228 740 IKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLP-GEYTQMAGRAGRRGLDKIGTVIVMCRD 805
Cdd:PRK02362 330 IKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAGMQPIPvLEYHQMAGRAGRPGLDPYGEAVLLAKS 396
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
356-797 |
1.49e-31 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 133.08 E-value: 1.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 356 FELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGLLT----G 431
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELSRLRSLGMRVkisiG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 432 DVSLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHIN----IVLLSATV 503
Cdd:PRK01172 101 DYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLSSA-RYVNpdarILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 504 PNTIEFADWIGRTKQKrihvtgTTKRPVPLEHCIFYsgesykicENEIFLshglkaakdaskkktssvasgshvgasasn 583
Cdd:PRK01172 180 SNANELAQWLNASLIK------SNFRPVPLKLGILY--------RKRLIL------------------------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 584 DGARNRKNESFNRIKQNKHSGSQnlgnfsgtswgnqkngdsqnnwgsrrsdasswlllinklskrsllpVVIFCFSKNRC 663
Cdd:PRK01172 216 DGYERSQVDINSLIKETVNDGGQ----------------------------------------------VLVFVSSRKNA 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 664 DKSADSIYSI-----DLTSSSEKSEirvfcdkafsrlkGSDRTLPQIVRvqgllhRGIGVHHAGLLPIVKEVVEMLFCRG 738
Cdd:PRK01172 250 EDYAEMLIQHfpefnDFKVSSENNN-------------VYDDSLNEMLP------HGVAFHHAGLSNEQRRFIEEMFRNR 310
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1279791228 739 VIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIG 797
Cdd:PRK01172 311 YIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYG 369
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
371-865 |
1.40e-30 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 130.32 E-value: 1.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 371 KGDSVFVAAHTSAGKTVVAEYAFA-LATKHCTRAVYTAPIKTISNQKYRDFcgKF------DVGLLTGDVSLRPE----A 439
Cdd:PRK00254 38 EGKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKALAEEKYREF--KDweklglRVAMTTGDYDSTDEwlgkY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 440 SCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTIEFADWIGRTkqk 519
Cdd:PRK00254 116 DIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVGNAEELAEWLNAE--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 520 rihVTGTTKRPVPLEHCIFYSGesykicenEIFLSHGlkaakdaskkktssvasgshvgasasndgarnrKNESFnrikq 599
Cdd:PRK00254 193 ---LVVSDWRPVKLRKGVFYQG--------FLFWEDG---------------------------------KIERF----- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 600 nkhsgsqnlgnfsgtswgnqkngdsQNNWGSRRSDASswlllinKLSKRSLlpvvIFCFSKNRCDKSADSIySIDLTSSS 679
Cdd:PRK00254 224 -------------------------PNSWESLVYDAV-------KKGKGAL----VFVNTRRSAEKEALEL-AKKIKRFL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 680 EKSEIRvfcdkAFSRLKGSDRTLPQIVRVQGLLHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPA-R 758
Cdd:PRK00254 267 TKPELR-----ALKELADSLEENPTNEKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAfR 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 759 TVVFDTLRKFD-GKEFRQLLpgEYTQMAGRAGRRGLDKIGTVIVMCRDKIPEEKdLKRVIVGSATKL------ESQFRLT 831
Cdd:PRK00254 342 VIIRDTKRYSNfGWEDIPVL--EIQQMMGRAGRPKYDEVGEAIIVATTEEPSKL-MERYIFGKPEKLfsmlsnESAFRSQ 418
|
490 500 510
....*....|....*....|....*....|....*
gi 1279791228 832 YIMILHLLRVEELK-VEDMLKRSFaeFHAQKKLPE 865
Cdd:PRK00254 419 VLALITNFGVSNFKeLVNFLERTF--YAHQRKDLY 451
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
362-508 |
6.53e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 113.88 E-value: 6.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHC---TRAVYTAPIKTISNQKYRDFCGKFD-----VGLLTGDV 433
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLdngPQALVLAPTRELAEQIYEELKKLGKglglkVASLLGGD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 434 SLRPEAS------CLIMTTEILRSMLYRgADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTI 507
Cdd:pfam00270 84 SRKEQLEklkgpdILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLPRNL 162
|
.
gi 1279791228 508 E 508
Cdd:pfam00270 163 E 163
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
362-514 |
1.45e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 113.58 E-value: 1.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIYH-LEKGDSVFVAAHTSAGKTVVAEYA---FALATKhctRAVYTAPIKTISNQKYRDFCGK----FDVGLLTGDV 433
Cdd:cd18028 6 QAEAVRAgLLKGENLLISIPTASGKTLIAEMAmvnTLLEGG---KALYLVPLRALASEKYEEFKKLeeigLKVGISTGDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 434 SLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWeEVIIMLPRHIN----IVLLSATVPN 505
Cdd:cd18028 83 DEDDEwlgdYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTL-ESIVARLRRLNpntqIIGLSATIGN 161
|
....*....
gi 1279791228 506 TIEFADWIG 514
Cdd:cd18028 162 PDELAEWLN 170
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
354-532 |
5.71e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.81 E-value: 5.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 354 FPFELDTFQKEAIYHLEKGD-SVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDF------CGKF 424
Cdd:smart00487 5 GFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAleALKRGKGGRVLVLVPTRELAEQWAEELkklgpsLGLK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 425 DVGLLTGDVS-------LRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIV 497
Cdd:smart00487 85 VVGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLL 164
|
170 180 190
....*....|....*....|....*....|....*
gi 1279791228 498 LLSATVPNTIEFADWIGRTKQKRIHVTGTTKRPVP 532
Cdd:smart00487 165 LLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIE 199
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
359-522 |
2.69e-25 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 104.76 E-value: 2.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 359 DTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRA--VYTAPIKTISNQKYRDFCGKFD----------V 426
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLRESDDGvvVYVAPTKALVNQVVAEVYARFSkkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 427 GLLTGDVSLRPEASCLIMTT--EILRSMLY--RGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPrhINIVLLSAT 502
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLLspHNASWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSAT 160
|
170 180
....*....|....*....|
gi 1279791228 503 VPNTIEFADWIGRTKQKRIH 522
Cdd:cd18025 161 IGNPQKFHEWLQSVQRARKA 180
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
362-530 |
5.69e-21 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 92.42 E-value: 5.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIYHLEKGD-SVFVAAHTSAGKTVVAEYAFA-------LATKHCTRAVYTAPIKTISNQKYRDFCGKFD-----VGL 428
Cdd:cd18023 6 QSEVFPDLLYSDkNFVVSAPTGSGKTVLFELAILrllkernPLPWGNRKVVYIAPIKALCSEKYDDWKEKFGplglsCAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 429 LTGDV---SLRPEASC-LIMTT-EILRSMLYRGAD---IIRDIEWVIFDEVHYVNDvERGVVWEEVI-----------IM 489
Cdd:cd18023 86 LTGDTemdDTFEIQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEVVVsrmktlsssseLR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1279791228 490 LPRHINI--VLLSATVPNTIEFADWIGrTKQKRIHVTGTTKRP 530
Cdd:cd18023 165 GSTVRPMrfVAVSATIPNIEDLAEWLG-DNPAGCFSFGESFRP 206
|
|
| Ski2_N |
pfam17911 |
Ski2 N-terminal region; This region is the N-terminal extended region found in the Ski2 ... |
78-225 |
4.86e-19 |
|
Ski2 N-terminal region; This region is the N-terminal extended region found in the Ski2 protein. The Ski complex is a conserved multiprotein assembly required for the cytoplasmic functions of the exosome, including RNA turnover, surveillance, and interference. Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry.
Pssm-ID: 465562 Cd Length: 134 Bit Score: 84.63 E-value: 4.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 78 EKVGRQWDFDWFEMAKVSLDPSQPRSVvvptwvLPFERpkkDGTTGGTWEPCSV-QVDVSELNveAQESGSQPRMPGPAK 156
Cdd:pfam17911 1 DKAQRHWDRDKDYKSLLKIPPSPSRTT------LRFKR---DGLEGKIVGYKEVsLVEISNAT--AKNSLSLNRKPGPKS 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1279791228 157 DFVRGSINNRPFRPGGLDDSQSVDRILPVAASNGewvqEILNGGRAQFVPPILKQGLDLGDLKEYPNSW 225
Cdd:pfam17911 70 DFVRGSSSNLPFAPGGLDEEVLKDSEGVDSGLKR----LHRDEGGLLDVPPGFSRGLDFGEDEETDDDE 134
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
373-518 |
2.79e-16 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 78.45 E-value: 2.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 373 DSVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGL------LTGDVS--LR-PEASC 441
Cdd:cd18021 20 DNVFVGAPTGSGKTVCAELALlrHWRQNPKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvkLTGETStdLKlLAKSD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 442 LIMTT----EILrSMLYRGADIIRDIEWVIFDEVHYVNDVErGVVWEEVI-------IMLPRHINIVLLSATVPNTIEFA 510
Cdd:cd18021 100 VILATpeqwDVL-SRRWKQRKNVQSVELFIADELHLIGGEN-GPVYEVVVsrmryisSQLEKPIRIVGLSSSLANARDVG 177
|
....*...
gi 1279791228 511 DWIGRTKQ 518
Cdd:cd18021 178 EWLGASKS 185
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
365-514 |
9.17e-15 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 73.95 E-value: 9.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 365 AIYHLEkgDSVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGL------LTGDVSLR 436
Cdd:cd18022 12 TLYHTD--NNVLLGAPTGSGKTIAAELAMfrAFNKYPGSKVVYIAPLKALVRERVDDWKKRFEEKLgkkvveLTGDVTPD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 437 PE----ASCLIMTTE----ILRSMLYRGadIIRDIEWVIFDEVHYVNDvERGVVWeEVII----MLPRH----INIVLLS 500
Cdd:cd18022 90 MKaladADIIITTPEkwdgISRSWQTRE--YVQQVSLIIIDEIHLLGS-DRGPVL-EVIVsrmnYISSQtekpVRLVGLS 165
|
170
....*....|....
gi 1279791228 501 ATVPNTIEFADWIG 514
Cdd:cd18022 166 TALANAGDLANWLG 179
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
369-802 |
8.26e-14 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 76.47 E-value: 8.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 369 LEKGDSVFVAAHTSAGKTVVAEYA---FALATKhcTRAVYTAPIKTISNQKYRDFCGKFDVGLltgDVSLR--------- 436
Cdd:COG1202 222 LLEGKDQLVVSATATGKTLIGELAgikNALEGK--GKMLFLVPLVALANQKYEDFKDRYGDGL---DVSIRvgasrirdd 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 437 -----PEASCLIMTTEILRSMLYRGADIiRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHI----NIVLLSATVPNTI 507
Cdd:COG1202 297 gtrfdPNADIIVGTYEGIDHALRTGRDL-GDIGTVVIDEVHMLEDPERGHRLDGLIARL-KYYcpgaQWIYLSATVGNPE 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 508 EFAdwigrtKQKRIHVTGTTKRPVPLE-HCIFYSGESYKICENEIFlshglkaakdaskkktssvasgshvgasasndga 586
Cdd:COG1202 375 ELA------KKLGAKLVEYEERPVPLErHLTFADGREKIRIINKLV---------------------------------- 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 587 rnrKNEsFNRIKQNKHSGsQNLgnfsgtswgnqkngdsqnnwgsrrsdasswlllinklskrsllpvvIFCFSKNRCDKS 666
Cdd:COG1202 415 ---KRE-FDTKSSKGYRG-QTI----------------------------------------------IFTNSRRRCHEI 443
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 667 ADSIysidltsssekseirvfcdkafsrlkgsdrtlpqivrvqgllhrGIGV--HHAGLLPIVKEVVEMLFCRGVIKVLF 744
Cdd:COG1202 444 ARAL--------------------------------------------GYKAapYHAGLDYGERKKVERRFADQELAAVV 479
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1279791228 745 STETFAMGVNAPARTVVFDTLRKfdGKEFrqLLPGEYTQMAGRAGRRGLDKIGTVIVM 802
Cdd:COG1202 480 TTAALAAGVDFPASQVIFDSLAM--GIEW--LSVQEFHQMLGRAGRPDYHDRGKVYLL 533
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
741-802 |
5.22e-13 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 67.58 E-value: 5.22e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1279791228 741 KVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLD-KIGTVIVM 802
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHfPEGEVTTL 134
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
712-792 |
4.91e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.00 E-value: 4.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 712 LHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-ARTVVFDTLRKFdgkefrqllPGEYTQMAGRAGR 790
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWS---------PASYIQRIGRAGR 80
|
..
gi 1279791228 791 RG 792
Cdd:smart00490 81 AG 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
372-502 |
1.99e-11 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 63.19 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 372 GDSVFVAAHTSAGKTVVAE-YAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFD----VGLLTGDVSL-------RPEA 439
Cdd:cd00046 1 GENVLITAPTGSGKTLAALlAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGpgirVAVLVGGSSAeereknkLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1279791228 440 SCLIMTTE-ILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVweeviIMLPRHIN-------IVLLSAT 502
Cdd:cd00046 81 DIIIATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGAL-----ILDLAVRKaglknaqVILLSAT 146
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
360-510 |
8.57e-11 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 62.22 E-value: 8.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 360 TFQKEAIYHLEKGDSVFVAAHTSAGKTVvaeyAF------ALATKHCTRAVYTAPIKTISN---QKYRDF----CGKFDV 426
Cdd:cd17923 3 SHQAEAIEAARAGRSVVVTTGTASGKSL----CYqlpileALLRDPGSRALYLYPTKALAQdqlRSLRELleqlGLGIRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 427 GLLTGDVS-------LRPEASCLIMTTEILRSMLYRGAD----IIRDIEWVIFDEVHYVndveRGVVWEEVIIMLPR--- 492
Cdd:cd17923 79 ATYDGDTPreerraiIRNPPRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLRRlrr 154
|
170 180
....*....|....*....|....*
gi 1279791228 493 -------HINIVLLSATVPNTIEFA 510
Cdd:cd17923 155 lcrrygaDPQFILTSATIGNPAEHA 179
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
349-502 |
4.49e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 60.81 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 349 DMALDFPFELDTFQKEAIYHL------EKGDSVFVAAhTSAGKTVVAeYAFALATKHCTRAVYTAPIKTISNQKYRDFCG 422
Cdd:COG1061 72 DEASGTSFELRPYQQEALEALlaalerGGGRGLVVAP-TGTGKTVLA-LALAAELLRGKRVLVLVPRRELLEQWAEELRR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 423 KFDVGLLTGDvSLRPEASCLIMTTEILRSMLYRgADIIRDIEWVIFDEVHYVndveRGVVWEEVIIMLPRHInIVLLSAT 502
Cdd:COG1061 150 FLGDPLAGGG-KKDSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHA----GAPSYRRILEAFPAAY-RLGLTAT 222
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
372-513 |
1.37e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 55.67 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 372 GDSVFVAAHTSAGKTvvaEYAF-----ALATKHC--TRAVYTAPIKTISNQKYR---DFCGKFD----VGLLTGDVS--- 434
Cdd:cd17922 1 GRNVLIAAPTGSGKT---EAAFlpalsSLADEPEkgVQVLYISPLKALINDQERrleEPLDEIDleipVAVRHGDTSqse 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 435 ----LRPEASCLIMTTEILRSML-YRGAD-IIRDIEWVIFDEVHYVNDVERGV-------VWEEVIIMLPRHINivlLSA 501
Cdd:cd17922 78 kakqLKNPPGILITTPESLELLLvNKKLReLFAGLRYVVVDEIHALLGSKRGVqlellleRLRKLTGRPLRRIG---LSA 154
|
170
....*....|..
gi 1279791228 502 TVPNTIEFADWI 513
Cdd:cd17922 155 TLGNLEEAAAFL 166
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
362-513 |
5.36e-08 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 54.53 E-value: 5.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIYH--LEKGDSVFVAAHTSAGKTVVAEyAFALATKHCTR--AVYTAPIKTISNQKYRDFCGKF-DVGLL------- 429
Cdd:cd18026 21 QKECLSLpgLLEGRNLVYSLPTSGGKTLVAE-ILMLKRLLERRkkALFVLPYVSIVQEKVDALSPLFeELGFRvegyagn 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 430 --TGDVSLRPEASCLIMTTEILRSMLYRG--ADIIRDIEWVIFDEVHYVNDVERGVVWE----EVIIMLPRHINIVLLSA 501
Cdd:cd18026 100 kgRSPPKRRKSLSVAVCTIEKANSLVNSLieEGRLDELGLVVVDELHMLGDGHRGALLEllltKLLYAAQKNIQIVGMSA 179
|
170
....*....|..
gi 1279791228 502 TVPNTIEFADWI 513
Cdd:cd18026 180 TLPNLEELASWL 191
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
360-510 |
2.36e-07 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 55.23 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 360 TFQKEAIYHLEKGDSVFVAAHTSAGKTvvaeYAF------ALATKHCTRAVYTAPIKTISN---QKYRDFCGKFDVGL-- 428
Cdd:COG1205 59 SHQAEAIEAARAGKNVVIATPTASGKS----LAYllpvleALLEDPGATALYLYPTKALARdqlRRLRELAEALGLGVrv 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 429 --LTGDVS------LRPEASCLIMTTEIL-RSMLYRG---ADIIRDIEWVIFDEVH-YvndveRGV----V-WeeVI--- 487
Cdd:COG1205 135 atYDGDTPpeerrwIREHPDIVLTNPDMLhYGLLPHHtrwARFFRNLRYVVIDEAHtY-----RGVfgshVaN--VLrrl 207
|
170 180
....*....|....*....|....*....
gi 1279791228 488 --IMlpRHIN----IVLLSATVPNTIEFA 510
Cdd:COG1205 208 rrIC--RHYGsdpqFILASATIGNPAEHA 234
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
716-792 |
5.61e-07 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 49.52 E-value: 5.61e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279791228 716 IGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDgkefrqllPGEYTQMAGRAGRRG 792
Cdd:pfam00271 41 VARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWN--------PASYIQRIGRAGRAG 109
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
364-522 |
6.52e-07 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 51.28 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 364 EAIYHLEkgDSVFVAAHTSAGKTVVAEYAFaLATKHCT------------RAVYTAPIKTISNQKYRDFCGKFD-----V 426
Cdd:cd18020 11 PVAYKTN--ENMLICAPTGAGKTNIAMLTI-LHEIRQHvnqggvikkddfKIVYIAPMKALAAEMVEKFSKRLAplgikV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 427 GLLTGDVSLRP---EASCLIMTTEILRSMLYRGA----DIIRDIEWVIFDEVHYVNDvERGVVWEEVIIMLPRH------ 493
Cdd:cd18020 88 KELTGDMQLTKkeiAETQIIVTTPEKWDVVTRKSsgdvALSQLVRLLIIDEVHLLHD-DRGPVIESLVARTLRQvestqs 166
|
170 180 190
....*....|....*....|....*....|
gi 1279791228 494 -INIVLLSATVPNTIEFADWIGRTKQKRIH 522
Cdd:cd18020 167 mIRIVGLSATLPNYLDVADFLRVNPYKGLF 196
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
361-502 |
1.95e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 48.84 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 361 FQKEAI----YHLEKGDSVFVAAhTSAGKTVVAEYAFALATKHctRAVYTAPIKTISNQ---KYRDFCGKFDVGLLTGDV 433
Cdd:cd17926 4 YQEEALeawlAHKNNRRGILVLP-TGSGKTLTALALIAYLKEL--RTLIVVPTDALLDQwkeRFEDFLGDSSIGLIGGGK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 434 S-LRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNdverGVVWEEVIIMLPRHiNIVLLSAT 502
Cdd:cd17926 81 KkDFDDANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHHLP----AKTFSEILKELNAK-YRLGLTAT 145
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
369-505 |
9.59e-06 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 48.14 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 369 LEKGDSVFVAAHTSAGKTVVAeyafaLAT------KHCTRA----------VYTAPIKTISNQKYRDFCGKFD-----VG 427
Cdd:cd18019 30 FETDENLLLCAPTGAGKTNVA-----LLTilreigKHRNPDgtinldafkiVYIAPMKALVQEMVGNFSKRLApygitVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 428 LLTGDVSLRPEAsclIMTTEILRSMLYRGADIIRD---------IEWVIFDEVHYVNDvERGVVWEEVIIMLPRHIN--- 495
Cdd:cd18019 105 ELTGDQQLTKEQ---ISETQIIVTTPEKWDIITRKsgdrtytqlVRLIIIDEIHLLHD-DRGPVLESIVARTIRQIEqtq 180
|
170
....*....|....
gi 1279791228 496 ----IVLLSATVPN 505
Cdd:cd18019 181 eyvrLVGLSATLPN 194
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
361-520 |
4.83e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 47.79 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 361 FQKEAIYHLEKGDSVFVAAHTSAGKT------VVAEYAF---ALATKHCTRAVYTAPIKTISN--------------QKY 417
Cdd:COG1201 28 PQREAWPAIAAGESTLLIAPTGSGKTlaaflpALDELARrprPGELPDGLRVLYISPLKALANdiernlrapleeigEAA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 418 RDFCGKFDVGLLTGDVS-------LR--PEasCLIMTTEILRSMLY--RGADIIRDIEWVIFDEVHYVNDVERGvvweeV 486
Cdd:COG1201 108 GLPLPEIRVGVRTGDTPaserqrqRRrpPH--ILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRG-----V 180
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1279791228 487 IIML---------PRHINIVLLSATVPNTIEFADWIGRTKQKR 520
Cdd:COG1201 181 HLALslerlralaPRPLQRIGLSATVGPLEEVARFLVGYEDPR 223
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
377-514 |
4.96e-05 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 48.00 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 377 VAAHTSAGKTVVA----------EYAFALATKH---CTRAVYTAPIKT---------------ISNQKYR--DFCGKFDV 426
Cdd:PRK09751 1 VIAPTGSGKTLAAflyaldrlfrEGGEDTREAHkrkTSRILYISPIKAlgtdvqrnlqiplkgIADERRRrgETEVNLRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 427 GLLTGDVS-------LRPEASCLIMTTEILRSMLY-RGADIIRDIEWVIFDEVHYVNDVERG----VVWEEVIIMLPRHI 494
Cdd:PRK09751 81 GIRTGDTPaqersklTRNPPDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170 180
....*....|....*....|
gi 1279791228 495 NIVLLSATVPNTIEFADWIG 514
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFLG 180
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
345-510 |
5.24e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 45.48 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 345 ELVPDMALDFPFELDTFQKEAI------YHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKY- 417
Cdd:cd17918 3 ALIQELCKSLPFSLTKDQAQAIkdiekdLHSPEPMDRLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYe 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 418 --RDFCGKFDVGLLTGDV--SLRPEASCLIMTTEILRSmlyrgADIIRDIEWVIFDEVHYVndverGVVWEEVIIMLpRH 493
Cdd:cd17918 83 eaRKFLPFINVELVTGGTkaQILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GA 151
|
170
....*....|....*...
gi 1279791228 494 INIVLLSAT-VPNTIEFA 510
Cdd:cd17918 152 THFLEATATpIPRTLALA 169
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
681-793 |
1.51e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 46.24 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 681 KSEIrVFCDkafSRLKGSDRTlpqiVRVQGllhRGIGV--HHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-A 757
Cdd:PRK11057 237 KSGI-IYCN---SRAKVEDTA----ARLQS---RGISAaaYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPnV 305
|
90 100 110
....*....|....*....|....*....|....*..
gi 1279791228 758 RTVV-FDTLRKFDgkefrqllpgEYTQMAGRAGRRGL 793
Cdd:PRK11057 306 RFVVhFDIPRNIE----------SYYQETGRAGRDGL 332
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
356-472 |
5.04e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 42.85 E-value: 5.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 356 FELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYA-------FALATKHCTRAVYTAPIKTISNQK---YRDFCGKFD 425
Cdd:cd18036 1 LELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYIcrhhlekRRSAGEKGRVVVLVNKVPLVEQQLekfFKYFRKGYK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1279791228 426 VGLLTGD----VSLRPEA---SCLIMTTEILRSMLYRGADIIR----DIEWVIFDEVH 472
Cdd:cd18036 81 VTGLSGDsshkVSFGQIVkasDVIICTPQILINNLLSGREEERvylsDFSLLIFDECH 138
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
707-793 |
8.35e-04 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 41.04 E-value: 8.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 707 RVQGLLHR-GI--GVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-ARTVVFDTLRK-FDGkefrqllpgeY 781
Cdd:cd18794 45 QVAARLQSkGIsaAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPdVRFVIHYSLPKsMES----------Y 114
|
90
....*....|..
gi 1279791228 782 TQMAGRAGRRGL 793
Cdd:cd18794 115 YQESGRAGRDGL 126
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
362-508 |
6.45e-03 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 40.52 E-value: 6.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 362 QKEAIYHLEKGDSVFVAAHTSAGKTVvaeyAFAL--------ATKHCTRAVYTAP-----------IKTISnqKYRDfcg 422
Cdd:COG0513 29 QAQAIPLILAGRDVLGQAQTGTGKTA----AFLLpllqrldpSRPRAPQALILAPtrelalqvaeeLRKLA--KYLG--- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279791228 423 kFDVGLLTGDVSLRPEasclimtteilRSMLYRGADII------------------RDIEWVIFDEVH------YVNDVE 478
Cdd:COG0513 100 -LRVATVYGGVSIGRQ-----------IRALKRGVDIVvatpgrlldliergaldlSGVETLVLDEADrmldmgFIEDIE 167
|
170 180 190
....*....|....*....|....*....|.
gi 1279791228 479 RgvvweevII-MLPRHINIVLLSATVPNTIE 508
Cdd:COG0513 168 R-------ILkLLPKERQTLLFSATMPPEIR 191
|
|
| |
