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Conserved domains on  [gi|1246170097|ref|XP_022430751|]
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U5 small nuclear ribonucleoprotein 40 kDa protein [Delphinapterus leucas]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 2.19e-82

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.38  E-value: 2.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246170097 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 2.19e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.38  E-value: 2.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246170097 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-352 2.97e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 244.17  E-value: 2.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 143 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 219
Cdd:cd00200    84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 220 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 299
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1246170097 300 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 123-313 1.16e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 123 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 202
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 203 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 278
Cdd:PLN00181  626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1246170097 279 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 313
Cdd:PLN00181  705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 1.34e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1246170097   59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 95
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
59-95 9.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 9.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1246170097  59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
58-352 2.19e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 256.38  E-value: 2.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 136
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 137 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGID 215
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 216 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWS 295
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFS 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246170097 296 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-352 2.97e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 244.17  E-value: 2.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 143 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 219
Cdd:cd00200    84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 220 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 299
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1246170097 300 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
19-353 3.96e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.50  E-value: 3.96e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  19 RPRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG 98
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  99 DcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVK 178
Cdd:COG2319   110 G-LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 179 LWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 257
Cdd:COG2319   188 LWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 258 NTVRVWDVRPfapkERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 337
Cdd:COG2319   268 GTVRLWDLAT----GELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                         330
                  ....*....|....*.
gi 1246170097 338 PDEPIILSASSDKRLY 353
Cdd:COG2319   340 PDGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
63-317 9.62e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.63  E-value: 9.62e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSET 141
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 142 GERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKV 220
Cdd:COG2319   236 GKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 221 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSK 300
Cdd:COG2319   315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA----TGELLRTLTG--H--TGAVTSVAFSPDGRT 386

                         250
                  ....*....|....*..
gi 1246170097 301 IAAGSADRFVYVWDTTS 317
Cdd:COG2319   387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-353 2.98e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.74  E-value: 2.98e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 102 NYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCtGSDDGTVKLWD 181
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 182 IRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 260
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 261 RVWDVRPFapkeRCVKIFQGnvHnfEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 340
Cdd:cd00200   160 KLWDLRTG----KCVATLTG--H--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                         250
                  ....*....|...
gi 1246170097 341 PIILSASSDKRLY 353
Cdd:cd00200   232 YLLASGSEDGTIR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-314 6.77e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.58  E-value: 6.77e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  63 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYaTLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 142
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 143 ERVKRLKGHTSFVNSCyPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 221
Cdd:cd00200   126 KCLTTLRGHTDWVNSV-AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 222 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSKI 301
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSG--H--TNSVTSLAWSPDGKRL 276

                         250
                  ....*....|...
gi 1246170097 302 AAGSADRFVYVWD 314
Cdd:cd00200   277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
121-352 9.41e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 9.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 121 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAV 200
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 201 TFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQG 280
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246170097 281 nvHnfEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRL 352
Cdd:COG2319   161 --H--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-264 6.53e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 6.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  59 PIMLLSGHEGEVYCCKFHPngstlasagfdrlillwnvygdcdnyatlkghsgavmelhyntDGSMLFSASTDKTVAVWD 138
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSP-------------------------------------------DGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 139 SETGERVKRLKGHTSFVNSCYPARRGPQLvCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 217
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGT 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1246170097 218 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:cd00200   243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 123-313 1.16e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 123 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 202
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 203 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 278
Cdd:PLN00181  626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1246170097 279 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 313
Cdd:PLN00181  705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 54-230 2.50e-18

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 86.10  E-value: 2.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  54 SSLQAPIMLLSGHEGEVYCCKFHPNG-STLASAGFDRLILLWNV-YGDCDNyaTLKGHSGAVMELHYNTDGSMLFSASTD 131
Cdd:PTZ00421  112 QNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVeRGKAVE--VIKCHSDQITSLEWNLDGSLLCTTSKD 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 132 KTVAVWDSETGERVKRLKGHTSF-VNSCYPARRGPQLV---CTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF----N 203
Cdd:PTZ00421  190 KKLNIIDPRDGTIVSSVEAHASAkSQRCLWAKRKDLIItlgCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIpffdE 269

                         170       180
                  ....*....|....*....|....*..
gi 1246170097 204 DTSDQIISGGIDNDIKVWDLRQNKLTY 230
Cdd:PTZ00421  270 DTNLLYIGSKGEGNIRCFELMNERLTF 296
WD40 COG2319
WD40 repeat [General function prediction only];
58-141 3.10e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  58 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 137
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                  ....
gi 1246170097 138 DSET 141
Cdd:COG2319   400 DLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 106-315 1.23e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.52  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 106 LKGHSGAVMELHYNT-DGSMLFSASTDKTVAVWD-------SETGERVKRLKGHtsfvnscyparrgpqlvctgsddgtv 177
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGH-------------------------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 178 klwdiRKKAAIQTFQ-NTYQVLAvtfndtsdqiiSGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 256
Cdd:PTZ00421  125 -----TKKVGIVSFHpSAMNVLA-----------SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSK 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246170097 257 DNTVRVWDVRpfapkeRCVKIFQGNVHNFEKNlLRCSWSPDGSKI----AAGSADRFVYVWDT 315
Cdd:PTZ00421  189 DKKLNIIDPR------DGTIVSSVEAHASAKS-QRCLWAKRKDLIitlgCSKSQQRQIMLWDT 244
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 1.34e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1246170097   59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 95
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 208-357 1.90e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 1.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 208 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN-TVRVWDVrpfapkERCVKIfqGNVHNfe 286
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSI------NQGVSI--GTIKT-- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246170097 287 KNLLRCSWSPD--GSKIAAGSADRFVYVWDTTSRRI-LYKLPGHAGSINEVAFhPDEPIILSASSDKRLYMGEI 357
Cdd:PLN00181  617 KANICCVQFPSesGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
59-95 9.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 9.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1246170097  59 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
226-264 2.33e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.33e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1246170097 226 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-264 2.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1246170097  225 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 264
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
77-265 3.63e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097  77 PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVKRLKGHTSFV 155
Cdd:COG3391    34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDLATGKVVATIPVGGGPR 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 156 NSCYpARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDND-----IKVWDLRQNKLTY 230
Cdd:COG3391   114 GLAV-DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVA 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1246170097 231 TMRGhADSVTGLSLSSEGSYLL--------SNAMDNTVRVWDV 265
Cdd:COG3391   193 TIPV-GGGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 6.25e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1246170097  104 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 138
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-181 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1246170097  141 TGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWD 181
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLA-SGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-138 1.19e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1246170097 104 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 138
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
142-181 1.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246170097 142 GERVKRLKGHTSFVNSCYPARRGpQLVCTGSDDGTVKLWD 181
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 209-284 2.07e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 2.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246170097 209 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 284
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEFPR 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 317-354 3.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1246170097  317 SRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYM 354
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
210-349 5.16e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246170097 210 ISGGIDNDIKVWDLRQNKLTYTMRgHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERcvkIFQGN-VHNFEk 287
Cdd:COG3391    84 VANSGSGRVSVIDLATGKVVATIP-VGGGPRGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVAT---IPVGAgPHGIA- 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246170097 288 nllrcsWSPDGSKIAAGSAD-----RFVYVWDTTSRRILYKLPGhAGSINEVAFHPDEPIILSASSD 349
Cdd:COG3391   159 ------VDPDGKRLYVANSGsntvsVIVSVIDTATGKVVATIPV-GGGPVGVAVSPDGRRLYVANRG 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-314 6.42e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1246170097  273 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 314
Cdd:smart00320   3 ELLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
318-354 1.42e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1246170097 318 RRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYM 354
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 pfam00400
WD domain, G-beta repeat;
273-314 4.02e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1246170097 273 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 314
Cdd:pfam00400   2 KLLKTLEGH----TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-222 1.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1246170097  188 IQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWD 222
Cdd:smart00320   5 LKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-222 8.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 8.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1246170097 197 VLAVTFNDTSDQIISGGIDNDIKVWD 222
Cdd:pfam00400  14 VTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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