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Conserved domains on  [gi|1229757564|ref|XP_022159887|]
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UDP-N-acetylglucosamine transferase subunit ALG13 homolog [Momordica charantia]

Protein Classification

glycosyltransferase family protein( domain architecture ID 10513712)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 13-161 3.05e-39

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


:

Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 131.30  E-value: 3.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  13 MVFVTVGTTCFDALVRAVdtEQVKQKLYARGYTHLLIQMGRGTYNPTKS-HGEDGLVVDYFSFSSSIADHLKSASLVISH 91
Cdd:pfam04101   1 TILVTGGSQGARALNELV--LSVLPLLELKGELQVLHQTGKGDLEEVKIdYAELGINYEVFPFIDNMAEYIKAADLVISR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1229757564  92 AGSGSIFETLRRGKPLIVVVNED----LMDNHQIELAEELAERKHLY-CARPQALHQTIEAMNLESLIPYTQGDA 161
Cdd:pfam04101  79 AGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQkELTPEKLIEALLKLLLNPLRLAEMAKA 153
 
Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 13-161 3.05e-39

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 131.30  E-value: 3.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  13 MVFVTVGTTCFDALVRAVdtEQVKQKLYARGYTHLLIQMGRGTYNPTKS-HGEDGLVVDYFSFSSSIADHLKSASLVISH 91
Cdd:pfam04101   1 TILVTGGSQGARALNELV--LSVLPLLELKGELQVLHQTGKGDLEEVKIdYAELGINYEVFPFIDNMAEYIKAADLVISR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1229757564  92 AGSGSIFETLRRGKPLIVVVNED----LMDNHQIELAEELAERKHLY-CARPQALHQTIEAMNLESLIPYTQGDA 161
Cdd:pfam04101  79 AGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQkELTPEKLIEALLKLLLNPLRLAEMAKA 153
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
14-156 2.47e-36

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 123.02  E-value: 2.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  14 VFVTVGTTCFDALVRAVDTEQVKQKLYargytHLLIQMGRGTYNPtkSHGEdglvvdYFSFSSSIADHLKSASLVISHAG 93
Cdd:NF041548    1 IFVTVGTTRFDSLIKAIDELIEGLIDY-----EVTFQIGDGKYIP--KNGE------YFDFLEEIDEYYKKADLIITHAG 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229757564  94 SGSIFETLRRGKPLIVVVNEDLMDNHQIELAEELAERKH-LYCARPQALHQTIEAMNLESLIPY 156
Cdd:NF041548   68 AGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYaLVCYDLDELEDAIKEAENFKPNPY 131
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
13-176 7.55e-26

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 96.92  E-value: 7.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  13 MVFVTVGTTC--FDALVRAVDteqvkqKLYARGYT--HLLIQMGRGTYNPTKshgedglvVDYFSF--SSSIADHLKSAS 86
Cdd:COG5017     1 MIFVTVGTHQlpFDRLVRWVD------ELAAEGIIdeEVFVQTGHTTYVPRN--------AEAVPFlpPDEFQKLIAQAR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  87 LVISHAGSGSIFETLRRGKPLIVV-----VNEDlMDNHQIELAEELAERKHLYCAR-PQALHQTI-EAMNLESLIPYTQG 159
Cdd:COG5017    67 LVISHAGMGSILTALKLGKPFILVprlarYGEH-VDDHQLETARALEKLGGIIVVEdPADLEAALdEALALKSPEPFSVP 145

                         170
                  ....*....|....*..
gi 1229757564 160 DAKPvGRLINRFLGFPE 176
Cdd:COG5017   146 SPAR-GALVDFLRAFIT 161
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 25-129 4.33e-09

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 54.53  E-value: 4.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  25 ALVRAVdtEQVKQKLYARGYTHLLiQMGRGTYNPTKSHGEDGLV-VDYFSFSSSIADHLKSASLVISHAGSGSIFETLRR 103
Cdd:cd03785   195 AINRAV--PKALPKLLERGIQVIH-QTGKGDYDEVKKLYEDLGInVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAA 271

                          90       100
                  ....*....|....*....|....*.
gi 1229757564 104 GKPLIVVVNEDLMDNHQIELAEELAE 129
Cdd:cd03785   272 GKPAILIPYPYAADDHQEANARALEK 297
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 46-130 3.04e-06

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 45.89  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  46 HLLIQMGRGTYNPTKSHGEDGLVVDYFSFSSSIADHLKSASLVISHAGSGSIFETLRRGKPLIVV----VNedlmDNHQI 121
Cdd:PRK00726  214 QVIHQTGKGDLEEVRAAYAAGINAEVVPFIDDMAAAYAAADLVICRAGASTVAELAAAGLPAILVplphAA----DDHQT 289


                  ....*....
gi 1229757564 122 ELAEELAER 130
Cdd:PRK00726  290 ANARALVDA 298
 
Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 13-161 3.05e-39

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 131.30  E-value: 3.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  13 MVFVTVGTTCFDALVRAVdtEQVKQKLYARGYTHLLIQMGRGTYNPTKS-HGEDGLVVDYFSFSSSIADHLKSASLVISH 91
Cdd:pfam04101   1 TILVTGGSQGARALNELV--LSVLPLLELKGELQVLHQTGKGDLEEVKIdYAELGINYEVFPFIDNMAEYIKAADLVISR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1229757564  92 AGSGSIFETLRRGKPLIVVVNED----LMDNHQIELAEELAERKHLY-CARPQALHQTIEAMNLESLIPYTQGDA 161
Cdd:pfam04101  79 AGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQkELTPEKLIEALLKLLLNPLRLAEMAKA 153
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
14-156 2.47e-36

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 123.02  E-value: 2.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  14 VFVTVGTTCFDALVRAVDTEQVKQKLYargytHLLIQMGRGTYNPtkSHGEdglvvdYFSFSSSIADHLKSASLVISHAG 93
Cdd:NF041548    1 IFVTVGTTRFDSLIKAIDELIEGLIDY-----EVTFQIGDGKYIP--KNGE------YFDFLEEIDEYYKKADLIITHAG 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229757564  94 SGSIFETLRRGKPLIVVVNEDLMDNHQIELAEELAERKH-LYCARPQALHQTIEAMNLESLIPY 156
Cdd:NF041548   68 AGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYaLVCYDLDELEDAIKEAENFKPNPY 131
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
13-176 7.55e-26

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 96.92  E-value: 7.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  13 MVFVTVGTTC--FDALVRAVDteqvkqKLYARGYT--HLLIQMGRGTYNPTKshgedglvVDYFSF--SSSIADHLKSAS 86
Cdd:COG5017     1 MIFVTVGTHQlpFDRLVRWVD------ELAAEGIIdeEVFVQTGHTTYVPRN--------AEAVPFlpPDEFQKLIAQAR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  87 LVISHAGSGSIFETLRRGKPLIVV-----VNEDlMDNHQIELAEELAERKHLYCAR-PQALHQTI-EAMNLESLIPYTQG 159
Cdd:COG5017    67 LVISHAGMGSILTALKLGKPFILVprlarYGEH-VDDHQLETARALEKLGGIIVVEdPADLEAALdEALALKSPEPFSVP 145

                         170
                  ....*....|....*..
gi 1229757564 160 DAKPvGRLINRFLGFPE 176
Cdd:COG5017   146 SPAR-GALVDFLRAFIT 161
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 23-130 4.76e-10

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 57.06  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  23 FDALVRAVDteqvkqKLYARGYtHLLIQMGRGTYNPTKSHGEDGLVVDY--FSFSSSIADHLKSASLVISHAGSGSIFET 100
Cdd:COG0707   202 NEAVPAALA------ALLEARL-QVVHQTGKGDYEEVRAAYAAAIRPNAevFPFIDDMADAYAAADLVISRAGASTVAEL 274

                          90       100       110
                  ....*....|....*....|....*....|
gi 1229757564 101 LRRGKPLIVVVNEDLMDNHQIELAEELAER 130
Cdd:COG0707   275 AALGKPAILVPLPHAADDHQTKNARALVEA 304
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
14-130 1.95e-09

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 54.86  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  14 VFVTVGTTC------FDALVRAVDTEQVkqklyargytHLLIQMGRGTYNPTKSHGEDGLVVDYFSFSssiaDHLKSASL 87
Cdd:COG1819   123 VYVTLGTSAndradlLRAVLEALADLGV----------RVVVTTGGLDPAELGPLPDNVRVVDYVPQD----ALLPRADA 188

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1229757564  88 VISHAGSGSIFETLRRGKPLIVV-VNEDlmdnhQIELAEELAER 130
Cdd:COG1819   189 VVHHGGAGTTAEALRAGVPQVVVpFGGD-----QPLNAARVERL 227
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 25-129 4.33e-09

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 54.53  E-value: 4.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  25 ALVRAVdtEQVKQKLYARGYTHLLiQMGRGTYNPTKSHGEDGLV-VDYFSFSSSIADHLKSASLVISHAGSGSIFETLRR 103
Cdd:cd03785   195 AINRAV--PKALPKLLERGIQVIH-QTGKGDYDEVKKLYEDLGInVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAA 271

                          90       100
                  ....*....|....*....|....*.
gi 1229757564 104 GKPLIVVVNEDLMDNHQIELAEELAE 129
Cdd:cd03785   272 GKPAILIPYPYAADDHQEANARALEK 297
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 46-130 3.04e-06

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 45.89  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  46 HLLIQMGRGTYNPTKSHGEDGLVVDYFSFSSSIADHLKSASLVISHAGSGSIFETLRRGKPLIVV----VNedlmDNHQI 121
Cdd:PRK00726  214 QVIHQTGKGDLEEVRAAYAAGINAEVVPFIDDMAAAYAAADLVICRAGASTVAELAAAGLPAILVplphAA----DDHQT 289


                  ....*....
gi 1229757564 122 ELAEELAER 130
Cdd:PRK00726  290 ANARALVDA 298
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 14-110 1.20e-04

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 41.38  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229757564  14 VFVTVGTTCFDalvravDTEQVKQKLY---ARGYTHLLIQMGRGTYNPTKSHGEDGLVVDYFSFSSsIADHlKSASLVIS 90
Cdd:cd03784   242 VYVSFGSMVRD------LPEELLELIAealASLGQRFLWVVGPDPLGGLERLPDNVLVVKWVPQDE-LLAH-PAVGAFVT 313

                          90       100
                  ....*....|....*....|
gi 1229757564  91 HAGSGSIFETLRRGKPLIVV 110
Cdd:cd03784   314 HGGWNSTLEALYAGVPMVVV 333
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 101-131 5.45e-03

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 36.57  E-value: 5.45e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1229757564 101 LRRGKPLIVVVNE-DLMDNHQIELAEELAERK 131
Cdd:PRK00093  281 LEAGRALVIVVNKwDLVDEKTMEEFKKELRRR 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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