NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1229184787|ref|XP_022106095|]
View 

PR domain zinc finger protein 16-like isoform X3 [Acanthaster planci]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 66-200 6.33e-77

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


:

Pssm-ID: 380977  Cd Length: 135  Bit Score: 249.59  E-value: 6.33e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   66 AVYVPEDVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCAWEIVDADGRVRCWIDASEPGTGN 145
Cdd:cd19200      1 PVYIPEDIPIPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVGVQRSSVKDPTYAWEIVDEFGKVKFWIDASEPGTGN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1229184787  146 WMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLVLKEAAFPDQEGIPI 200
Cdd:cd19200     81 WMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPHETMPP 135
zf-H2C2_2 pfam13465
Zinc-finger double domain;
902-926 1.49e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.49e-05
                           10        20
                   ....*....|....*....|....*
gi 1229184787  902 NLTRHLRTHTGEQPYSCKYCDRSFS 926
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 888-910 6.09e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.13  E-value: 6.09e-05
                           10        20
                   ....*....|....*....|...
gi 1229184787  888 YTCKYCGKLFPRSANLTRHLRTH 910
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 319-340 8.01e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 8.01e-05
                           10        20
                   ....*....|....*....|..
gi 1229184787  319 FPCEHCDKTFSDPSNLQRHIRT 340
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 321-366 1.91e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 1.91e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1229184787  321 CEHCDKTFSDPSNLQRHIRTQHVgarshACPECGKTFATSSGLKQH 366
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHF-----KCHICHKKLYTAGGLAVH 44
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
283-564 2.25e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  283 SEYRANRDFHCDKCPKSFHWKSNLLRHQNEHSSDHQFPCEH--CDKTFSDPSNLQRHIRTQHVGARSHACPECGKTFATS 360
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  361 SGLKQHTHIHSSIKPFICEVCLKS----YTQFSNLcrHKRMHADCRTQLKCNNCSQMFATVTSLNK-HRRFCHGNQLLNN 435
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHSLPpssrDPQLPDL--LSISNLRNNPLPGNNSSSVNTPQSNSLHPpLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  436 QISTTQAASVPSVVRNGSC-PVMTPNPSLIGVGMLGANNPLHPANLAHLwnaNLHLTHQALLQNNLLGYPGSDKTPLPSH 514
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENsPLSSSYSIPSSSSDQNLENSSSSLPLTTN---SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1229184787  515 PYFMGYSPMPTQSPLLPSNFNKQNHTSRSGSGGTSPNGSINSaDDWLKHY 564
Cdd:COG5048    261 PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRS-SPLTRHL 309
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 945-967 4.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.73e-03
                           10        20
                   ....*....|....*....|...
gi 1229184787  945 FKCPLCERCFGQQTNLDRHLKKH 967
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 66-200 6.33e-77

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 249.59  E-value: 6.33e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   66 AVYVPEDVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCAWEIVDADGRVRCWIDASEPGTGN 145
Cdd:cd19200      1 PVYIPEDIPIPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVGVQRSSVKDPTYAWEIVDEFGKVKFWIDASEPGTGN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1229184787  146 WMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLVLKEAAFPDQEGIPI 200
Cdd:cd19200     81 WMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPHETMPP 135
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 77-186 2.41e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 53.49  E-value: 2.41e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787    77 PEFELRESCIqeAGLGVFSLVDIPVGERFGPFAGV--------ERSLVQDMLCAWEIVDADGRVRCWIDASEpgTGNWMK 148
Cdd:smart00317    1 NKLEVFKSPG--KGWGVRATEDIPKGEFIGEYVGEiitseeaeERPKAYDTDGAKAFYLFDIDSDLCIDARR--KGNLAR 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1229184787   149 YVRSAATfEDQNMVPVQIEN--KVYFKVIRPIGPGKELLV 186
Cdd:smart00317   77 FINHSCE-PNCELLFVEVNGddRIVIFALRDIKPGEELTI 115
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 90-186 8.26e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 49.06  E-value: 8.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   90 GLGVFSLVDIPVGERFGPFAGV------------ERSLVQDMLCAWE--IVDADGRVRCWIDASEPGTGNWMKYVRSAAt 155
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVllitkeeadkreLLYYDKLELRLWGpyLFTLDEDSEYCIDARALYYGNWARFINHSC- 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1229184787  156 feDQNM----VPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:pfam00856   80 --DPNCevrvVYVNGGPRIVIFALRDIKPGEELTI 112
zf-H2C2_2 pfam13465
Zinc-finger double domain;
902-926 1.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.49e-05
                           10        20
                   ....*....|....*....|....*
gi 1229184787  902 NLTRHLRTHTGEQPYSCKYCDRSFS 926
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 888-910 6.09e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.13  E-value: 6.09e-05
                           10        20
                   ....*....|....*....|...
gi 1229184787  888 YTCKYCGKLFPRSANLTRHLRTH 910
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 319-340 8.01e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 8.01e-05
                           10        20
                   ....*....|....*....|..
gi 1229184787  319 FPCEHCDKTFSDPSNLQRHIRT 340
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 321-366 1.91e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 1.91e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1229184787  321 CEHCDKTFSDPSNLQRHIRTQHVgarshACPECGKTFATSSGLKQH 366
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHF-----KCHICHKKLYTAGGLAVH 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
869-940 2.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1229184787  869 STVLYPSSGEKMIMRSKDRYT--CKYCGKLFPRSANLTRHLRTHTGEQPYSCKY--CDRSFSISSNLQRHVRNIHN 940
Cdd:COG5048     13 NSVLSSTPKSTLKSLSNAPRPdsCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-564 2.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  283 SEYRANRDFHCDKCPKSFHWKSNLLRHQNEHSSDHQFPCEH--CDKTFSDPSNLQRHIRTQHVGARSHACPECGKTFATS 360
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  361 SGLKQHTHIHSSIKPFICEVCLKS----YTQFSNLcrHKRMHADCRTQLKCNNCSQMFATVTSLNK-HRRFCHGNQLLNN 435
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHSLPpssrDPQLPDL--LSISNLRNNPLPGNNSSSVNTPQSNSLHPpLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  436 QISTTQAASVPSVVRNGSC-PVMTPNPSLIGVGMLGANNPLHPANLAHLwnaNLHLTHQALLQNNLLGYPGSDKTPLPSH 514
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENsPLSSSYSIPSSSSDQNLENSSSSLPLTTN---SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1229184787  515 PYFMGYSPMPTQSPLLPSNFNKQNHTSRSGSGGTSPNGSINSaDDWLKHY 564
Cdd:COG5048    261 PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRS-SPLTRHL 309
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-359 4.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.11e-03
                           10        20
                   ....*....|....*....|....*..
gi 1229184787  333 NLQRHIRTqHVGARSHACPECGKTFAT 359
Cdd:pfam13465    1 NLKRHMRT-HTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 945-967 4.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.73e-03
                           10        20
                   ....*....|....*....|...
gi 1229184787  945 FKCPLCERCFGQQTNLDRHLKKH 967
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 915-967 6.61e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 6.61e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1229184787  915 PYSCKYCDRSFSISSNLQRHVR-NIHNKekpfKCPLCERCF-GQQTNLDRHLKKH 967
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRyTEHSK----VCPVCGKEFrNTDSTLDHVCKKH 123
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
882-927 6.65e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 39.85  E-value: 6.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1229184787  882 MRSKDRYTCKYCGklfprSANLTRHLRTHTGEQPYSCKYCDRSFSI 927
Cdd:COG3677     11 IRWPNGPVCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFTV 51
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 349-427 9.23e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 9.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  349 ACPECGKTFATSSGLKQHTHIHSSI------KPFICEV--CLKSYTQFSNLCRHKRMHADCRTQLKCNNCSQMFATVTSL 420
Cdd:pfam15909    3 SSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRSL 82


                   ....*..
gi 1229184787  421 NKHRRFC 427
Cdd:pfam15909   83 FKHLHVC 89
ZnF_C2H2 smart00355
zinc finger;
888-910 9.26e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 9.26e-03
                            10        20
                    ....*....|....*....|...
gi 1229184787   888 YTCKYCGKLFPRSANLTRHLRTH 910
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 66-200 6.33e-77

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 249.59  E-value: 6.33e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   66 AVYVPEDVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCAWEIVDADGRVRCWIDASEPGTGN 145
Cdd:cd19200      1 PVYIPEDIPIPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVGVQRSSVKDPTYAWEIVDEFGKVKFWIDASEPGTGN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1229184787  146 WMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLVLKEAAFPDQEGIPI 200
Cdd:cd19200     81 WMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPHETMPP 135
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 65-194 1.23e-43

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 156.19  E-value: 1.23e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   65 AAVYVPEDVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCAWE-----------------IVD 127
Cdd:cd19213     10 APVYIPDDIPIPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTGVQRSTLKDTNFGWEqilndvevssqegcitkIVD 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1229184787  128 ADGRVRCWIDASEPGTGNWMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV-LKEAAFPD 194
Cdd:cd19213     90 DLGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVyVKDGVYPL 157
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 65-198 5.67e-37

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 136.61  E-value: 5.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   65 AAVYVPEDVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCAWEIVDADGRVRCWIDASEPGTG 144
Cdd:cd19214     20 APIYIPDDIPIPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEVLDEFGNVKFCIDASQPDVG 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1229184787  145 NWMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLVLKEAAFPDQEGI 198
Cdd:cd19214    100 SWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMKSEDYSHETM 153
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 72-186 5.90e-33

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 124.09  E-value: 5.90e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   72 DVVLPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAG--VERSLVQDMLCAWEIVDADGRVRCwIDASEPGTGNWMKY 149
Cdd:cd19188      1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGekKKRSQVKNNVYMWEIYGPKRGWMC-VDASDPTKGNWLRY 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1229184787  150 VRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19188     80 VNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLC 116
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 75-186 1.17e-29

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 114.64  E-value: 1.17e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAG--VERSLVQDMLCAWEIvDADGRVRCWIDASEPGTGNWMKYVRS 152
Cdd:cd19193      4 LPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGeiVEDEEAADSGYSWQI-YKGGKLSHYIDAKDESKSNWMRYVNC 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1229184787  153 AATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19193     83 ARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLV 116
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 75-186 2.91e-26

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 103.43  E-value: 2.91e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVErslvqdmlcaweivdadgrvrcwidasepgtgNWMKYVRSAA 154
Cdd:cd10534      1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV--------------------------------NWMRFVRPAR 48

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1229184787  155 TFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd10534     49 NEEEQNLVAYQHGGQIYFRTTRDIPPGEELLV 80
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 75-186 1.74e-22

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 94.35  E-value: 1.74e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLC-----AWEIVDADGRVRCWIDASEPGTGNWMKY 149
Cdd:cd19196      1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCknnnlMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1229184787  150 VRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19196     81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLV 117
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 75-186 1.63e-21

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 91.38  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGVERSLVQDMLCA------WEIVDADGRVRCWIDASEPGTGNWMK 148
Cdd:cd19191      1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrntqhlWEIYDQEGTLQHFIDGGDPSKSSWMR 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1229184787  149 YVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19191     81 YIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLV 118
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 75-186 2.03e-21

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 90.87  E-value: 2.03e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELREScIQEAGL--GVFSLVDIPVGERFGPFAGVERSLVQDMLCAWEIVDADGRVR-CWIDASEPGtGNWMKYVR 151
Cdd:cd19201      3 LPGELELRKP-SQDAGRsgGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVEAQGSKGGeGLLLLTEDS-GTWLKLVR 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1229184787  152 SAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19201     81 SADDEDEANLILYFKGGQIWCEVTKDIPPGEELIL 115
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 75-186 2.15e-21

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 91.23  E-value: 2.15e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVDIPVGERFGPFAGvERSLVQdmlcawEIVDADGRVRCW-----------IDASEPGT 143
Cdd:cd19187      3 LPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVG-EIYTND------PVPKGANRKYFWriysngefyhyIDGFDPSK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1229184787  144 GNWMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19187     76 SNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLV 118
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 92-200 1.25e-17

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 80.52  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   92 GVFSLVDIPVGERFGPFAG--VERSLVQ---DMLCAWEIVdADGRVRCWIDAsEPGTGNWMKYVRSAATFEDQNMVPVQI 166
Cdd:cd19198     21 GVFCKKTIPKGTRFGPFRGrvVNTSEIKtydDNSFMWEIF-EDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQC 98

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1229184787  167 ENKVYFKVIRPIGPGKELLVLKEAAFPDQEGIPI 200
Cdd:cd19198     99 QGQIFYESCKEILQGQELLVWYGDCYLQFMGIPV 132
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 75-186 2.60e-15

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 73.87  E-value: 2.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEaGLGVFSLVDIPVGERFGPFAGVER---SLVQDMLC--AWEIVDADGRVRCWIDASEPGTGNWMKY 149
Cdd:cd19190      5 VPDRFSLKSSKVQD-GMGLYTARRVKKGEKFGPFAGEKRmpnELDESMDPrlMWEVRGSKGEVLYILDASNPRHSNWLRF 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1229184787  150 VRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19190     84 VHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLI 120
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 75-186 6.28e-15

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 72.45  E-value: 6.28e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELREscIQEAGLGVFSLVDIPVGERFGPF-AGVERSLVQDMLCAWEIVDADGRVRCwIDASEPGTGNWMKYVRSA 153
Cdd:cd19199      7 LPDNLEIRQ--LEDGSEGVFALVPLVKRTQFGPFeAKRVARLDGFAVFPLKVFEKDGSVVY-LDTSNEDDCNWMMFVRPA 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1229184787  154 ATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19199     84 TDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRV 116
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 75-186 6.90e-15

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 72.50  E-value: 6.90e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQeAGLGVFSLVDIPVGERFGPFAG-------VERSLVQDMLCAWEIVDADGRVRCwIDASEPGTGNWM 147
Cdd:cd19189      6 LPRQLYLRQSETG-AEVGVWTKETIPVRTCFGPLIGqqshsaeVADWTDKAAPHIWKIYHNDVLEFC-IITTDENECNWM 83

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1229184787  148 KYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19189     84 MFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLF 122
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 91-186 1.03e-14

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 72.00  E-value: 1.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   91 LGVFSLVDIPVGERFGPFAG--VERSLVQDMLCAWEIVDADGRVRCWIDASEPGTGNWMKYVRSAATFEDQNMVPVQIEN 168
Cdd:cd19194     20 GGVFAKRRIPKRTQFGPLEGplVKKSELKDNKIHPLELEEDDGEDLYFDLSDENKCNWMMFVRPAQNHLEQNLVAYQYGQ 99

                           90
                   ....*....|....*...
gi 1229184787  169 KVYFKVIRPIGPGKELLV 186
Cdd:cd19194    100 EIYFTTIKNIEPKQELKV 117
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 75-189 2.12e-13

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 67.83  E-value: 2.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   75 LPPEFELRESCIQEAGLGVFSLVD-IPVGERFGPFAGVErslvqdmlcawEIVDADGRVR-------CWIDASEPGT-GN 145
Cdd:cd10520      5 LPPGLALGPSLAQEERLGVWCVGDaLQKGTFLGPLEEEL-----------ESHDLTEGGSprqeesgQSGDVLACEQsSK 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1229184787  146 WMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLVLKE 189
Cdd:cd10520     74 WMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPE 117
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 65-186 1.75e-10

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 59.87  E-value: 1.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   65 AAVYVPE--DVVLPPEFELRESCIQEAglgvfslvdIPVGERFGPFAGveRSLVQDM---LCAWEIVDADGRVRCwIDAS 139
Cdd:cd19195      1 AALTAPQgiEVVKDTSGESDVRCVDEV---------IPKGHIFGPYEG--QICTQDKssgFFSWLIVDKNNRYKS-IDGS 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1229184787  140 EPGTGNWMKYVRSAATFEDQNMVPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:cd19195     69 DETKANWMRYVVISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRV 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 77-186 2.41e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 53.49  E-value: 2.41e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787    77 PEFELRESCIqeAGLGVFSLVDIPVGERFGPFAGV--------ERSLVQDMLCAWEIVDADGRVRCWIDASEpgTGNWMK 148
Cdd:smart00317    1 NKLEVFKSPG--KGWGVRATEDIPKGEFIGEYVGEiitseeaeERPKAYDTDGAKAFYLFDIDSDLCIDARR--KGNLAR 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1229184787   149 YVRSAATfEDQNMVPVQIEN--KVYFKVIRPIGPGKELLV 186
Cdd:smart00317   77 FINHSCE-PNCELLFVEVNGddRIVIFALRDIKPGEELTI 115
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 92-186 5.28e-08

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 52.82  E-value: 5.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   92 GVFSLVDIPVGERFGPFAGVERSLVQDMLCA-----WEIVDADGRVRCWIDASEPGTGNWMKYVRSAATFEDQNM-VPVQ 165
Cdd:cd19192     21 SVVTTTDIPAGTIFGPCVLSFTLGYDIADIAlkttdKRVVPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLeAFRK 100

                           90       100
                   ....*....|....*....|.
gi 1229184787  166 IENKVYFKVIRPIGPGKELLV 186
Cdd:cd19192    101 NEGQVYFRTLRRIRKGEELLV 121
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 90-186 8.26e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 49.06  E-value: 8.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   90 GLGVFSLVDIPVGERFGPFAGV------------ERSLVQDMLCAWE--IVDADGRVRCWIDASEPGTGNWMKYVRSAAt 155
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVllitkeeadkreLLYYDKLELRLWGpyLFTLDEDSEYCIDARALYYGNWARFINHSC- 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1229184787  156 feDQNM----VPVQIENKVYFKVIRPIGPGKELLV 186
Cdd:pfam00856   80 --DPNCevrvVYVNGGPRIVIFALRDIKPGEELTI 112
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 86-186 1.44e-05

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 45.80  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   86 IQEAGLGVFSLVDIPVGERFGPFAGVERS-LVQDMLCAWEI-------VDADGRVrcwIDASEpgTGNWMKYVRSAATFe 157
Cdd:cd10522     10 LSHNGLGLFAAETIAKGEFVGEYTGEVLDrWEEDRDSVYHYdplypfdLNGDILV---IDAGK--KGNLTRFINHSDQP- 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1229184787  158 dqNMVPVQI----ENKVYFKVIRPIGPGKELLV 186
Cdd:cd10522     84 --NLELIVRtlkgEQHIGFVAIRDIKPGEELFI 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
902-926 1.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.49e-05
                           10        20
                   ....*....|....*....|....*
gi 1229184787  902 NLTRHLRTHTGEQPYSCKYCDRSFS 926
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 888-910 6.09e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.13  E-value: 6.09e-05
                           10        20
                   ....*....|....*....|...
gi 1229184787  888 YTCKYCGKLFPRSANLTRHLRTH 910
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 319-340 8.01e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 8.01e-05
                           10        20
                   ....*....|....*....|..
gi 1229184787  319 FPCEHCDKTFSDPSNLQRHIRT 340
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 99-186 1.38e-04

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 42.50  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787   99 IPVGERFGPFAGVERSL--VQDMLCAWEIVDAD-GRVRCWIDASEPGTGNWMKYVRSAATFEDQNMVPVQ--IENKVYFK 173
Cdd:cd19197      1 IPAGLRLGPVPGIFKLGkyLSDRKEPGNKKKVRrVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIAdlPGGQIFYR 80

                           90
                   ....*....|...
gi 1229184787  174 VIRPIGPGKELLV 186
Cdd:cd19197     81 ALRDIQPGEELTV 93
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 321-366 1.91e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 1.91e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1229184787  321 CEHCDKTFSDPSNLQRHIRTQHVgarshACPECGKTFATSSGLKQH 366
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHF-----KCHICHKKLYTAGGLAVH 44
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 319-342 1.51e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 1.51e-03
                           10        20
                   ....*....|....*....|....
gi 1229184787  319 FPCEHCDKTFSDPSNLQRHIRTQH 342
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTHH 24
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 318-342 1.87e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.76  E-value: 1.87e-03
                           10        20
                   ....*....|....*....|....*.
gi 1229184787  318 QFPCEHCDKTFSDPSNLQRHIRT-QH 342
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLKSkKH 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
869-940 2.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1229184787  869 STVLYPSSGEKMIMRSKDRYT--CKYCGKLFPRSANLTRHLRTHTGEQPYSCKY--CDRSFSISSNLQRHVRNIHN 940
Cdd:COG5048     13 NSVLSSTPKSTLKSLSNAPRPdsCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-564 2.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  283 SEYRANRDFHCDKCPKSFHWKSNLLRHQNEHSSDHQFPCEH--CDKTFSDPSNLQRHIRTQHVGARSHACPECGKTFATS 360
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  361 SGLKQHTHIHSSIKPFICEVCLKS----YTQFSNLcrHKRMHADCRTQLKCNNCSQMFATVTSLNK-HRRFCHGNQLLNN 435
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHSLPpssrDPQLPDL--LSISNLRNNPLPGNNSSSVNTPQSNSLHPpLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  436 QISTTQAASVPSVVRNGSC-PVMTPNPSLIGVGMLGANNPLHPANLAHLwnaNLHLTHQALLQNNLLGYPGSDKTPLPSH 514
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENsPLSSSYSIPSSSSDQNLENSSSSLPLTTN---SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1229184787  515 PYFMGYSPMPTQSPLLPSNFNKQNHTSRSGSGGTSPNGSINSaDDWLKHY 564
Cdd:COG5048    261 PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRS-SPLTRHL 309
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-359 4.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.11e-03
                           10        20
                   ....*....|....*....|....*..
gi 1229184787  333 NLQRHIRTqHVGARSHACPECGKTFAT 359
Cdd:pfam13465    1 NLKRHMRT-HTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 945-967 4.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.73e-03
                           10        20
                   ....*....|....*....|...
gi 1229184787  945 FKCPLCERCFGQQTNLDRHLKKH 967
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 915-967 6.61e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 6.61e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1229184787  915 PYSCKYCDRSFSISSNLQRHVR-NIHNKekpfKCPLCERCF-GQQTNLDRHLKKH 967
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRyTEHSK----VCPVCGKEFrNTDSTLDHVCKKH 123
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
882-927 6.65e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 39.85  E-value: 6.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1229184787  882 MRSKDRYTCKYCGklfprSANLTRHLRTHTGEQPYSCKYCDRSFSI 927
Cdd:COG3677     11 IRWPNGPVCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFTV 51
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 916-936 8.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 8.20e-03
                           10        20
                   ....*....|....*....|.
gi 1229184787  916 YSCKYCDRSFSISSNLQRHVR 936
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLR 21
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 349-427 9.23e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 9.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229184787  349 ACPECGKTFATSSGLKQHTHIHSSI------KPFICEV--CLKSYTQFSNLCRHKRMHADCRTQLKCNNCSQMFATVTSL 420
Cdd:pfam15909    3 SSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRSL 82


                   ....*..
gi 1229184787  421 NKHRRFC 427
Cdd:pfam15909   83 FKHLHVC 89
ZnF_C2H2 smart00355
zinc finger;
888-910 9.26e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 9.26e-03
                            10        20
                    ....*....|....*....|...
gi 1229184787   888 YTCKYCGKLFPRSANLTRHLRTH 910
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH