|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
62-255 |
4.93e-109 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 329.48 E-value: 4.93e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17977 81 VGYVIPFENCCTNETIL------------------RYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142
|
170 180 190
....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17977 143 VLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
259-422 |
9.45e-53 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 180.42 E-value: 9.45e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 259 HPVEVVYLSEA-----------QKDSFESILRLIFEIHRSGEKGDIVVFLACEQDIEKVYEIVYQgSNLNPDLGELVVVP 327
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-ELLSPDLGKLLVLP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 328 LYPKEKCSLFKPLDEtekKCQVYQRRVVLTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRK 407
Cdd:cd18791 80 LHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 1220237856 408 QILGSSSSGKFFCLY 422
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
60-705 |
2.00e-51 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 194.51 E-value: 2.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 60 EDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNI 138
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK----GLIGhTQPRRLAARTVANRIAEELETEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:PRK11131 147 GGCVGYKVRFNDQVSDNTMVK------------------LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGY 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 219 LKDVLLARPELKLIINSS---PHLISKlnsYYGNLPLIEVKSK-HPVEVVY--LSE----AQKDSFESILRLIFEIHRSG 288
Cdd:PRK11131 209 LKELLPRRPDLKVIITSAtidPERFSR---HFNNAPIIEVSGRtYPVEVRYrpIVEeaddTERDQLQAIFDAVDELGREG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 289 eKGDIVVFLACEQDIEKVYEIVyqgSNLNpdLGELVVVPLYPKekcslfkpLDETEKKcQVYQ----RRVVLTTSSGESL 364
Cdd:PRK11131 286 -PGDILIFMSGEREIRDTADAL---NKLN--LRHTEILPLYAR--------LSNSEQN-RVFQshsgRRIVLATNVAETS 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 365 IWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdmtplKPA----EM 439
Cdd:PRK11131 351 LTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS------RPEftdpEI 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 440 QEANLTSMVLFMKRIdiaGLGHCD---FMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKS 511
Cdd:PRK11131 425 LRTNLASVILQMTAL---GLGDIAafpFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARM 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 512 ILASCEFDCVDEVLTIAAMVTA--PNcfsHVPHGAEEAALTCWKTFLHPEGDHFTLISI--YKAYQDTTLNSTSeycVEK 587
Cdd:PRK11131 502 VLEAQKHGCVREVMIITSALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLwnYLQEQQKALSSNQ---FRR 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 588 WCHDYFLNCSALRMADVIRAELLEIIKRIELPY-AEPAfgskeNCLNIKKALLSGYFMQIA-RDVD-----GSGNylmlt 660
Cdd:PRK11131 576 LCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN----- 645
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 1220237856 661 hkqvAQLHPLSGYSVTKKMPEWVLFHQFSISENNYIRITSEISPE 705
Cdd:PRK11131 646 ----ARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPE 686
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
75-534 |
9.34e-49 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 184.90 E-value: 9.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 75 LLQNQIVIVSGDAKCGKSSQVPQWCAEyclSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTN 154
Cdd:COG1643 23 LRAHQVVVLAAPPGAGKTTQLPLALLE---LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 155 ETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATD--------VLLGLlkdvllaR 226
Cdd:COG1643 100 ATRIE------------------VVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------R 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 227 PELKLIINS--------SPHLisklnsyyGNLPLIEVKSK-HPVEVVYL--SEAQKDSFESILRLIFEIHRSGEkGDIVV 295
Cdd:COG1643 155 PDLKLLVMSatldaerfARLL--------GDAPVIESSGRtYPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 296 FLACEQDIEKVYEIvyqgsnLNPDLG-ELVVVPLY----PKEKCSLFKPLDETekkcqvyQRRVVLTTSSGESliwsnS- 369
Cdd:COG1643 226 FLPGEREIRRTAEA------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET-----Sl 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 370 ----VKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdMTPLKPAEMQEANL 444
Cdd:COG1643 288 tvpgIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEdFAR--RPAFTDPEILRADL 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 445 TSMVLFMKRI---DIAGLghcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCV 521
Cdd:COG1643 366 ASLILELAAWglgDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442
|
490
....*....|...
gi 1220237856 522 DEVLTIAAMVTAP 534
Cdd:COG1643 443 REAAILAALLSER 455
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
476-565 |
4.79e-25 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 100.00 E-value: 4.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 476 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCF---SHVPHGAEEAALTCW 552
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqpNFLDPRSAAKAARRR 80
|
90 100
....*....|....*....|....
gi 1220237856 553 KTFLHPE-----------GDHFTL 565
Cdd:pfam04408 81 RRAADEKarakfarldleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
482-566 |
1.30e-22 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 92.33 E-value: 1.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 482 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFshvPHGAEEAALTCWKTFLHPEGD 561
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77
|
....*
gi 1220237856 562 HFTLI 566
Cdd:smart00847 78 HLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
634-714 |
4.80e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 87.69 E-value: 4.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 634 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGY-SVTKKMPEWVLFHQFSISENNYIRITSEISPELFMQLVP 712
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 1220237856 713 QY 714
Cdd:pfam07717 81 HI 82
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
62-255 |
4.93e-109 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 329.48 E-value: 4.93e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17977 81 VGYVIPFENCCTNETIL------------------RYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142
|
170 180 190
....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17977 143 VLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
62-255 |
6.47e-64 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 210.91 E-value: 6.47e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQ-IVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17986 81 EVGYSIPQEDCTGPNTIL------------------RFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLK 142
|
170 180 190
....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17986 143 DVRLQRPELRVVVVTSPALEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
51-255 |
2.82e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 188.01 E-value: 2.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 51 RYYKLLKEREDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSiHYQHGGVICTQVHKQAVVQLALRV 130
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELP-HQPKKLVACTQPRRVAAMSVAQRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 131 ADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSI 210
Cdd:cd17973 81 AEEMDVKLGEEVGYSIRFEDCSSAKTILK------------------YMTDGMLLREAMSDPLLSRYSVIILDEAHERTL 142
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1220237856 211 ATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17973 143 ATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
78-255 |
7.71e-55 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 185.74 E-value: 7.71e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 78 NQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETI 157
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKG-GKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 158 LRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSP 237
Cdd:cd17917 80 IK------------------FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSAT 141
|
170
....*....|....*...
gi 1220237856 238 HLISKLNSYYGNLPLIEV 255
Cdd:cd17917 142 LDAEKFSSYFGGAPVIHI 159
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
259-422 |
9.45e-53 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 180.42 E-value: 9.45e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 259 HPVEVVYLSEA-----------QKDSFESILRLIFEIHRSGEKGDIVVFLACEQDIEKVYEIVYQgSNLNPDLGELVVVP 327
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-ELLSPDLGKLLVLP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 328 LYPKEKCSLFKPLDEtekKCQVYQRRVVLTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRK 407
Cdd:cd18791 80 LHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 1220237856 408 QILGSSSSGKFFCLY 422
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
60-705 |
2.00e-51 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 194.51 E-value: 2.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 60 EDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNI 138
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK----GLIGhTQPRRLAARTVANRIAEELETEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:PRK11131 147 GGCVGYKVRFNDQVSDNTMVK------------------LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGY 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 219 LKDVLLARPELKLIINSS---PHLISKlnsYYGNLPLIEVKSK-HPVEVVY--LSE----AQKDSFESILRLIFEIHRSG 288
Cdd:PRK11131 209 LKELLPRRPDLKVIITSAtidPERFSR---HFNNAPIIEVSGRtYPVEVRYrpIVEeaddTERDQLQAIFDAVDELGREG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 289 eKGDIVVFLACEQDIEKVYEIVyqgSNLNpdLGELVVVPLYPKekcslfkpLDETEKKcQVYQ----RRVVLTTSSGESL 364
Cdd:PRK11131 286 -PGDILIFMSGEREIRDTADAL---NKLN--LRHTEILPLYAR--------LSNSEQN-RVFQshsgRRIVLATNVAETS 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 365 IWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdmtplKPA----EM 439
Cdd:PRK11131 351 LTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS------RPEftdpEI 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 440 QEANLTSMVLFMKRIdiaGLGHCD---FMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKS 511
Cdd:PRK11131 425 LRTNLASVILQMTAL---GLGDIAafpFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARM 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 512 ILASCEFDCVDEVLTIAAMVTA--PNcfsHVPHGAEEAALTCWKTFLHPEGDHFTLISI--YKAYQDTTLNSTSeycVEK 587
Cdd:PRK11131 502 VLEAQKHGCVREVMIITSALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLwnYLQEQQKALSSNQ---FRR 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 588 WCHDYFLNCSALRMADVIRAELLEIIKRIELPY-AEPAfgskeNCLNIKKALLSGYFMQIA-RDVD-----GSGNylmlt 660
Cdd:PRK11131 576 LCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN----- 645
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 1220237856 661 hkqvAQLHPLSGYSVTKKMPEWVLFHQFSISENNYIRITSEISPE 705
Cdd:PRK11131 646 ----ARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPE 686
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
75-534 |
9.34e-49 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 184.90 E-value: 9.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 75 LLQNQIVIVSGDAKCGKSSQVPQWCAEyclSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTN 154
Cdd:COG1643 23 LRAHQVVVLAAPPGAGKTTQLPLALLE---LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 155 ETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATD--------VLLGLlkdvllaR 226
Cdd:COG1643 100 ATRIE------------------VVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------R 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 227 PELKLIINS--------SPHLisklnsyyGNLPLIEVKSK-HPVEVVYL--SEAQKDSFESILRLIFEIHRSGEkGDIVV 295
Cdd:COG1643 155 PDLKLLVMSatldaerfARLL--------GDAPVIESSGRtYPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 296 FLACEQDIEKVYEIvyqgsnLNPDLG-ELVVVPLY----PKEKCSLFKPLDETekkcqvyQRRVVLTTSSGESliwsnS- 369
Cdd:COG1643 226 FLPGEREIRRTAEA------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET-----Sl 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 370 ----VKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdMTPLKPAEMQEANL 444
Cdd:COG1643 288 tvpgIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEdFAR--RPAFTDPEILRADL 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 445 TSMVLFMKRI---DIAGLghcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCV 521
Cdd:COG1643 366 ASLILELAAWglgDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442
|
490
....*....|...
gi 1220237856 522 DEVLTIAAMVTAP 534
Cdd:COG1643 443 REAAILAALLSER 455
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
58-255 |
8.11e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 144.93 E-value: 8.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 58 EREDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSihyQHGGVICTQVHKQAVVQLALRVADEMDVN 137
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYT---SRGKIGCTQPRRVAAMSVAKRVAEEFGCC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 138 IGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLG 217
Cdd:cd17971 79 LGQEVGYTIRFEDCTSPETVIK------------------YMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFG 140
|
170 180 190
....*....|....*....|....*....|....*...
gi 1220237856 218 LLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17971 141 LLKKTVQKRPDLKLIVTSATLDAVKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
62-255 |
6.18e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 136.48 E-value: 6.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAE--YClsihyQHGGVI-CTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEagYT-----KGGGKIgCTQPRRVAAMSVAARVAEEMGVKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:cd17974 76 GNEVGYSIRFEDCTSEKTVLK------------------YMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGL 137
|
170 180 190
....*....|....*....|....*....|....*..
gi 1220237856 219 LKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17974 138 VKDIARFRPDLKLLISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
62-236 |
4.48e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 131.44 E-value: 4.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEyclsIHYQHGG--VICTQVHKQAVVQLALRVADEMDVNIG 139
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE----AGWTAGGrvVGCTQPRRVAAVTVAGRVAEEMGAVLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 HEVGYVIPFENCCTnetilrhsyfrcgglkyKGTHGDRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLL 219
Cdd:cd17980 77 HEVGYCIRFDDCTD-----------------PQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLL 139
|
170
....*....|....*..
gi 1220237856 220 KDVLLARPELKLIINSS 236
Cdd:cd17980 140 KKIQKKRGDLRLIVASA 156
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
62-253 |
1.46e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 127.09 E-value: 1.46e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGGVI-CTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQ----YLYEAGFARGGMIgITQPRRVAAVSVAKRVAEEMGVELGQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17978 77 LVGYSVRFDDVTSEETRIK------------------YMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVK 138
|
170 180 190
....*....|....*....|....*....|....*...
gi 1220237856 221 DVLLAR-----PELKLIINSSPHLISKLNSYYGNLPLI 253
Cdd:cd17978 139 SAQRRRkeqklSPLKVIIMSATLDADLFSEYFNGAPVL 176
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
62-255 |
5.60e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 125.27 E-value: 5.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGGVI-CTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQ----YLHEDGYTDYGMIgCTQPRRVAAMSVAKRVSEEMGVELGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17983 77 EVGYAIRFEDCTSENTVIK------------------YMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLR 138
|
170 180 190
....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17983 139 EVVARRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
62-255 |
3.94e-30 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 117.26 E-value: 3.94e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSihyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS---QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDV-----LL 216
Cdd:cd17984 78 VGYQVRFDDCSSKETAIK------------------YMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDIlfgllKK 139
|
170 180 190
....*....|....*....|....*....|....*....
gi 1220237856 217 GLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17984 140 LFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
62-255 |
1.21e-29 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 115.62 E-value: 1.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHggVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQ----YLLAAGFRH--IACTQPRRIACISLAKRVAFESLNQYGSK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17979 75 VAYQIRFERTRTLATKLL------------------FLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRC 136
|
170 180 190
....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17979 137 LLRLRPDLKLILMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
62-235 |
4.37e-25 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 103.20 E-value: 4.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQ--WCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVnIG 139
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQflYEAGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 HEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVL---- 215
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIK------------------FMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILigml 141
|
170 180
....*....|....*....|....*..
gi 1220237856 216 -------LGLLKDVLLARPeLKLIINS 235
Cdd:cd17982 142 srivplrAKLYLQDQTVKP-LKLVIMS 167
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
476-565 |
4.79e-25 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 100.00 E-value: 4.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 476 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCF---SHVPHGAEEAALTCW 552
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqpNFLDPRSAAKAARRR 80
|
90 100
....*....|....*....|....
gi 1220237856 553 KTFLHPE-----------GDHFTL 565
Cdd:pfam04408 81 RRAADEKarakfarldleGDHLTL 104
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
62-255 |
3.68e-24 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 99.91 E-value: 3.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCL-SIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17985 81 SVGYQIRLESVKSSATRLL------------------YCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLK 142
|
170 180 190
....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17985 143 DLMVQRPDLKVILMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
62-255 |
5.39e-24 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 99.45 E-value: 5.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIR----GLIGhTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17989 77 AVGYKVRFTDQTSDETCVK------------------LMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLK 138
|
170 180 190
....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17989 139 QLLPRRPDLKVIITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
62-255 |
1.27e-23 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 98.33 E-value: 1.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAE-YCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNetilrhsyfRCGGLkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17976 81 NVGYQVRLESRPPP---------RGGAL--------LFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLK 143
|
170 180 190
....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17976 144 GVLQLNPELRVVLMSATGDNQRLSRYFGGCPVVRV 178
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
482-566 |
1.30e-22 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 92.33 E-value: 1.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 482 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFshvPHGAEEAALTCWKTFLHPEGD 561
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77
|
....*
gi 1220237856 562 HFTLI 566
Cdd:smart00847 78 HLTLL 82
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
62-255 |
2.09e-22 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 94.91 E-value: 2.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGG-----VICTQVHKQAVVQLALRVADEM-- 134
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQ----FILDDAIERGKgsscrIVCTQPRRISAISVAERVAAERae 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 135 DVNIGHEVGYVIPFENCCTNE--TILrhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIAT 212
Cdd:cd17981 77 SCGLGNSTGYQIRLESRKPRKqgSIL-------------------YCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQS 137
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1220237856 213 DVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17981 138 DVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
9-255 |
8.51e-22 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 94.90 E-value: 8.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 9 PNSSPEKRYFPESldSSDGDEEEVLAC--EDLELNPFDGLPY----SSRYYKLLKEREDLPIWKEKYSFMEKLLQNQIVI 82
Cdd:cd17972 2 PWSPPQSNWNPWT--SSNIDEGPLAFAtpEQISMDLKNELMYqreqDHNLQQILQERELLPVKKFREEILEAISNNPVVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 83 VSGDAKCGKSSQVPQWCA-EYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFEncctneTILRHS 161
Cdd:cd17972 80 IRGATGCGKTTQVPQYILdDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFE------SVLPRP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 162 YfrcGGLkykgthgdRYCTDDMLQREMMSnpflGSYGV--IILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHL 239
Cdd:cd17972 154 H---ASI--------LFCTVGVLLRKLEA----GIRGIshVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATID 218
|
250
....*....|....*.
gi 1220237856 240 ISKLNSYYGNLPLIEV 255
Cdd:cd17972 219 TSMFCEYFFNCPVIEV 234
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
634-714 |
4.80e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 87.69 E-value: 4.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 634 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGY-SVTKKMPEWVLFHQFSISENNYIRITSEISPELFMQLVP 712
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 1220237856 713 QY 714
Cdd:pfam07717 81 HI 82
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
62-255 |
6.23e-21 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 90.66 E-value: 6.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYClsihYQHGG---VICTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDC----YANGIpcrIFCTQPRRLAAIAVAERVAAERGEKI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMS-NPFLGSYGVIILDDIHERSIATDVLLG 217
Cdd:cd17987 77 GQTVGYQIRLESRVSPKTLLT------------------FCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLT 138
|
170 180 190
....*....|....*....|....*....|....*...
gi 1220237856 218 LLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17987 139 KLRDILQKHPNLKLILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
127-533 |
5.70e-20 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 94.99 E-value: 5.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 127 ALRVADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIH 206
Cdd:PRK11664 65 AQRLAEQLGEKPGETVGYRMRAESKVGPNTRLE------------------VVTEGILTRMIQRDPELSGVGLVILDEFH 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 207 ERSIATDVLLGLLKDVLLA-RPELKLIINSSPHLISKLNSYYGNLPLIEVKSK-HPVEVVYLSEAQKDSFE-----SILR 279
Cdd:PRK11664 127 ERSLQADLALALLLDVQQGlRDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRsFPVERRYQPLPAHQRFDeavarATAE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 280 LIFEihrsgEKGDIVVFLACEQDIEKVYEivyqgsNLNPDLGELVVV-PLYPkekcSLfkPLDETEKKCQ---VYQRRVV 355
Cdd:PRK11664 207 LLRQ-----ESGSLLLFLPGVGEIQRVQE------QLASRVASDVLLcPLYG----AL--SLAEQQKAILpapAGRRKVV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 356 LTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKdmTPLK 435
Cdd:PRK11664 270 LATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER--AAAQ 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 436 P-AEMQEANLTSMVLfmkriDIAGLGHCD-----FMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLS 509
Cdd:PRK11664 348 SePEILHSDLSGLLL-----ELLQWGCHDpaqlsWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA 422
|
410 420
....*....|....*....|....
gi 1220237856 510 KSILASCEFDcvDEVLTIAAMVTA 533
Cdd:PRK11664 423 AMLVAAKEDD--EAALATAAKLAA 444
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
62-255 |
1.66e-19 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 86.89 E-value: 1.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHG--GVICTQVHKQAVVQLALRVADEMDVNIG 139
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQkcNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 -----HEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDV 214
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLL------------------YCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDF 142
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1220237856 215 LLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17975 143 LLIILKEILHKRSDLHLILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
62-209 |
1.94e-13 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 69.07 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHG---GVICTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQ----FILDHYYKRGkycNIVVTQPRRIAAISIARRVSQEREWTL 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERS 209
Cdd:cd17988 77 GSLVGYQVGLERPASEETRLI------------------YCTTGVLLQKLINNKTLTEYTHIILDEVHERD 129
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
90-255 |
1.60e-10 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 60.42 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 90 GKSSQVP----QWCAEyclsihyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrc 165
Cdd:cd17990 29 GKTTRVPlallAELWI-------AGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGRRTRVE------ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 166 gglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLA-RPELKLIINSSPHLISKLN 244
Cdd:cd17990 96 ------------VVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAMSATLDGDGLA 163
|
170
....*....|.
gi 1220237856 245 SYYGNLPLIEV 255
Cdd:cd17990 164 ALLPEAPVVES 174
|
|
|