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Conserved domains on  [gi|1220237856|ref|XP_021799771|]
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putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1 [Papio anubis]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 62-255 4.93e-109

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 329.48  E-value: 4.93e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17977    81 VGYVIPFENCCTNETIL------------------RYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17977   143 VLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 259-422 9.45e-53

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 180.42  E-value: 9.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 259 HPVEVVYLSEA-----------QKDSFESILRLIFEIHRSGEKGDIVVFLACEQDIEKVYEIVYQgSNLNPDLGELVVVP 327
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-ELLSPDLGKLLVLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 328 LYPKEKCSLFKPLDEtekKCQVYQRRVVLTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRK 407
Cdd:cd18791    80 LHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156

                         170
                  ....*....|....*
gi 1220237856 408 QILGSSSSGKFFCLY 422
Cdd:cd18791   157 GRAGRTRPGKCYRLY 171
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 476-565 4.79e-25

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


:

Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 100.00  E-value: 4.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 476 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCF---SHVPHGAEEAALTCW 552
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqpNFLDPRSAAKAARRR 80

                          90       100
                  ....*....|....*....|....
gi 1220237856 553 KTFLHPE-----------GDHFTL 565
Cdd:pfam04408  81 RRAADEKarakfarldleGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 634-714 4.80e-21

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 87.69  E-value: 4.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 634 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGY-SVTKKMPEWVLFHQFSISENNYIRITSEISPELFMQLVP 712
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1220237856 713 QY 714
Cdd:pfam07717  81 HI 82
 
Name Accession Description Interval E-value
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 62-255 4.93e-109

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 329.48  E-value: 4.93e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17977    81 VGYVIPFENCCTNETIL------------------RYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17977   143 VLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 259-422 9.45e-53

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 180.42  E-value: 9.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 259 HPVEVVYLSEA-----------QKDSFESILRLIFEIHRSGEKGDIVVFLACEQDIEKVYEIVYQgSNLNPDLGELVVVP 327
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-ELLSPDLGKLLVLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 328 LYPKEKCSLFKPLDEtekKCQVYQRRVVLTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRK 407
Cdd:cd18791    80 LHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156

                         170
                  ....*....|....*
gi 1220237856 408 QILGSSSSGKFFCLY 422
Cdd:cd18791   157 GRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 60-705 2.00e-51

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 194.51  E-value: 2.00e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856   60 EDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNI 138
Cdd:PRK11131    71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK----GLIGhTQPRRLAARTVANRIAEELETEL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:PRK11131   147 GGCVGYKVRFNDQVSDNTMVK------------------LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGY 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  219 LKDVLLARPELKLIINSS---PHLISKlnsYYGNLPLIEVKSK-HPVEVVY--LSE----AQKDSFESILRLIFEIHRSG 288
Cdd:PRK11131   209 LKELLPRRPDLKVIITSAtidPERFSR---HFNNAPIIEVSGRtYPVEVRYrpIVEeaddTERDQLQAIFDAVDELGREG 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  289 eKGDIVVFLACEQDIEKVYEIVyqgSNLNpdLGELVVVPLYPKekcslfkpLDETEKKcQVYQ----RRVVLTTSSGESL 364
Cdd:PRK11131   286 -PGDILIFMSGEREIRDTADAL---NKLN--LRHTEILPLYAR--------LSNSEQN-RVFQshsgRRIVLATNVAETS 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  365 IWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdmtplKPA----EM 439
Cdd:PRK11131   351 LTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS------RPEftdpEI 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  440 QEANLTSMVLFMKRIdiaGLGHCD---FMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKS 511
Cdd:PRK11131   425 LRTNLASVILQMTAL---GLGDIAafpFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARM 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  512 ILASCEFDCVDEVLTIAAMVTA--PNcfsHVPHGAEEAALTCWKTFLHPEGDHFTLISI--YKAYQDTTLNSTSeycVEK 587
Cdd:PRK11131   502 VLEAQKHGCVREVMIITSALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLwnYLQEQQKALSSNQ---FRR 575

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  588 WCHDYFLNCSALRMADVIRAELLEIIKRIELPY-AEPAfgskeNCLNIKKALLSGYFMQIA-RDVD-----GSGNylmlt 660
Cdd:PRK11131   576 LCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN----- 645

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 1220237856  661 hkqvAQLHPLSGYSVTKKMPEWVLFHQFSISENNYIRITSEISPE 705
Cdd:PRK11131   646 ----ARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPE 686
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
75-534 9.34e-49

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 184.90  E-value: 9.34e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  75 LLQNQIVIVSGDAKCGKSSQVPQWCAEyclSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTN 154
Cdd:COG1643    23 LRAHQVVVLAAPPGAGKTTQLPLALLE---LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 155 ETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATD--------VLLGLlkdvllaR 226
Cdd:COG1643   100 ATRIE------------------VVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------R 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 227 PELKLIINS--------SPHLisklnsyyGNLPLIEVKSK-HPVEVVYL--SEAQKDSFESILRLIFEIHRSGEkGDIVV 295
Cdd:COG1643   155 PDLKLLVMSatldaerfARLL--------GDAPVIESSGRtYPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 296 FLACEQDIEKVYEIvyqgsnLNPDLG-ELVVVPLY----PKEKCSLFKPLDETekkcqvyQRRVVLTTSSGESliwsnS- 369
Cdd:COG1643   226 FLPGEREIRRTAEA------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET-----Sl 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 370 ----VKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdMTPLKPAEMQEANL 444
Cdd:COG1643   288 tvpgIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEdFAR--RPAFTDPEILRADL 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 445 TSMVLFMKRI---DIAGLghcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCV 521
Cdd:COG1643   366 ASLILELAAWglgDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442

                         490
                  ....*....|...
gi 1220237856 522 DEVLTIAAMVTAP 534
Cdd:COG1643   443 REAAILAALLSER 455
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 476-565 4.79e-25

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 100.00  E-value: 4.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 476 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCF---SHVPHGAEEAALTCW 552
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqpNFLDPRSAAKAARRR 80

                          90       100
                  ....*....|....*....|....
gi 1220237856 553 KTFLHPE-----------GDHFTL 565
Cdd:pfam04408  81 RRAADEKarakfarldleGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 482-566 1.30e-22

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 92.33  E-value: 1.30e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  482 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFshvPHGAEEAALTCWKTFLHPEGD 561
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77


                   ....*
gi 1220237856  562 HFTLI 566
Cdd:smart00847  78 HLTLL 82
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 634-714 4.80e-21

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 87.69  E-value: 4.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 634 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGY-SVTKKMPEWVLFHQFSISENNYIRITSEISPELFMQLVP 712
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1220237856 713 QY 714
Cdd:pfam07717  81 HI 82
 
Name Accession Description Interval E-value
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 62-255 4.93e-109

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 329.48  E-value: 4.93e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17977    81 VGYVIPFENCCTNETIL------------------RYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17977   143 VLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 62-255 6.47e-64

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 210.91  E-value: 6.47e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQ-IVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17986     1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILrhsyfrcgglkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17986    81 EVGYSIPQEDCTGPNTIL------------------RFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLK 142

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17986   143 DVRLQRPELRVVVVTSPALEPKLRAFWGNPPVVHV 177
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 51-255 2.82e-55

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 188.01  E-value: 2.82e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  51 RYYKLLKEREDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSiHYQHGGVICTQVHKQAVVQLALRV 130
Cdd:cd17973     2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELP-HQPKKLVACTQPRRVAAMSVAQRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 131 ADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSI 210
Cdd:cd17973    81 AEEMDVKLGEEVGYSIRFEDCSSAKTILK------------------YMTDGMLLREAMSDPLLSRYSVIILDEAHERTL 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1220237856 211 ATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17973   143 ATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 78-255 7.71e-55

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 185.74  E-value: 7.71e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  78 NQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETI 157
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKG-GKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 158 LRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSP 237
Cdd:cd17917    80 IK------------------FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSAT 141

                         170
                  ....*....|....*...
gi 1220237856 238 HLISKLNSYYGNLPLIEV 255
Cdd:cd17917   142 LDAEKFSSYFGGAPVIHI 159
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 259-422 9.45e-53

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 180.42  E-value: 9.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 259 HPVEVVYLSEA-----------QKDSFESILRLIFEIHRSGEKGDIVVFLACEQDIEKVYEIVYQgSNLNPDLGELVVVP 327
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-ELLSPDLGKLLVLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 328 LYPKEKCSLFKPLDEtekKCQVYQRRVVLTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRK 407
Cdd:cd18791    80 LHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156

                         170
                  ....*....|....*
gi 1220237856 408 QILGSSSSGKFFCLY 422
Cdd:cd18791   157 GRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 60-705 2.00e-51

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 194.51  E-value: 2.00e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856   60 EDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNI 138
Cdd:PRK11131    71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK----GLIGhTQPRRLAARTVANRIAEELETEL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:PRK11131   147 GGCVGYKVRFNDQVSDNTMVK------------------LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGY 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  219 LKDVLLARPELKLIINSS---PHLISKlnsYYGNLPLIEVKSK-HPVEVVY--LSE----AQKDSFESILRLIFEIHRSG 288
Cdd:PRK11131   209 LKELLPRRPDLKVIITSAtidPERFSR---HFNNAPIIEVSGRtYPVEVRYrpIVEeaddTERDQLQAIFDAVDELGREG 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  289 eKGDIVVFLACEQDIEKVYEIVyqgSNLNpdLGELVVVPLYPKekcslfkpLDETEKKcQVYQ----RRVVLTTSSGESL 364
Cdd:PRK11131   286 -PGDILIFMSGEREIRDTADAL---NKLN--LRHTEILPLYAR--------LSNSEQN-RVFQshsgRRIVLATNVAETS 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  365 IWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdmtplKPA----EM 439
Cdd:PRK11131   351 LTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS------RPEftdpEI 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  440 QEANLTSMVLFMKRIdiaGLGHCD---FMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKS 511
Cdd:PRK11131   425 LRTNLASVILQMTAL---GLGDIAafpFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARM 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  512 ILASCEFDCVDEVLTIAAMVTA--PNcfsHVPHGAEEAALTCWKTFLHPEGDHFTLISI--YKAYQDTTLNSTSeycVEK 587
Cdd:PRK11131   502 VLEAQKHGCVREVMIITSALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLwnYLQEQQKALSSNQ---FRR 575

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  588 WCHDYFLNCSALRMADVIRAELLEIIKRIELPY-AEPAfgskeNCLNIKKALLSGYFMQIA-RDVD-----GSGNylmlt 660
Cdd:PRK11131   576 LCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN----- 645

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 1220237856  661 hkqvAQLHPLSGYSVTKKMPEWVLFHQFSISENNYIRITSEISPE 705
Cdd:PRK11131   646 ----ARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPE 686
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
75-534 9.34e-49

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 184.90  E-value: 9.34e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  75 LLQNQIVIVSGDAKCGKSSQVPQWCAEyclSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTN 154
Cdd:COG1643    23 LRAHQVVVLAAPPGAGKTTQLPLALLE---LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 155 ETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATD--------VLLGLlkdvllaR 226
Cdd:COG1643   100 ATRIE------------------VVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------R 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 227 PELKLIINS--------SPHLisklnsyyGNLPLIEVKSK-HPVEVVYL--SEAQKDSFESILRLIFEIHRSGEkGDIVV 295
Cdd:COG1643   155 PDLKLLVMSatldaerfARLL--------GDAPVIESSGRtYPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 296 FLACEQDIEKVYEIvyqgsnLNPDLG-ELVVVPLY----PKEKCSLFKPLDETekkcqvyQRRVVLTTSSGESliwsnS- 369
Cdd:COG1643   226 FLPGEREIRRTAEA------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET-----Sl 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 370 ----VKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEE-FASkdMTPLKPAEMQEANL 444
Cdd:COG1643   288 tvpgIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEdFAR--RPAFTDPEILRADL 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 445 TSMVLFMKRI---DIAGLghcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCV 521
Cdd:COG1643   366 ASLILELAAWglgDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442

                         490
                  ....*....|...
gi 1220237856 522 DEVLTIAAMVTAP 534
Cdd:COG1643   443 REAAILAALLSER 455
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 58-255 8.11e-40

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 144.93  E-value: 8.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  58 EREDLPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSihyQHGGVICTQVHKQAVVQLALRVADEMDVN 137
Cdd:cd17971     2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYT---SRGKIGCTQPRRVAAMSVAKRVAEEFGCC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 138 IGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLG 217
Cdd:cd17971    79 LGQEVGYTIRFEDCTSPETVIK------------------YMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFG 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1220237856 218 LLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17971   141 LLKKTVQKRPDLKLIVTSATLDAVKFSQYFYEAPIFTI 178
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 62-255 6.18e-37

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 136.48  E-value: 6.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAE--YClsihyQHGGVI-CTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEagYT-----KGGGKIgCTQPRRVAAMSVAARVAEEMGVKL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGL 218
Cdd:cd17974    76 GNEVGYSIRFEDCTSEKTVLK------------------YMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGL 137

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1220237856 219 LKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17974   138 VKDIARFRPDLKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 62-236 4.48e-35

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 131.44  E-value: 4.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEyclsIHYQHGG--VICTQVHKQAVVQLALRVADEMDVNIG 139
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE----AGWTAGGrvVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 HEVGYVIPFENCCTnetilrhsyfrcgglkyKGTHGDRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLL 219
Cdd:cd17980    77 HEVGYCIRFDDCTD-----------------PQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLL 139

                         170
                  ....*....|....*..
gi 1220237856 220 KDVLLARPELKLIINSS 236
Cdd:cd17980   140 KKIQKKRGDLRLIVASA 156
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 62-253 1.46e-33

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 127.09  E-value: 1.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGGVI-CTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQ----YLYEAGFARGGMIgITQPRRVAAVSVAKRVAEEMGVELGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17978    77 LVGYSVRFDDVTSEETRIK------------------YMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVK 138

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1220237856 221 DVLLAR-----PELKLIINSSPHLISKLNSYYGNLPLI 253
Cdd:cd17978   139 SAQRRRkeqklSPLKVIIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 62-255 5.60e-33

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 125.27  E-value: 5.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGGVI-CTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQ----YLHEDGYTDYGMIgCTQPRRVAAMSVAKRVSEEMGVELGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17983    77 EVGYAIRFEDCTSENTVIK------------------YMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLR 138

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17983   139 EVVARRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 62-255 3.94e-30

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 117.26  E-value: 3.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSihyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS---QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDV-----LL 216
Cdd:cd17984    78 VGYQVRFDDCSSKETAIK------------------YMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDIlfgllKK 139

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1220237856 217 GLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17984   140 LFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 62-255 1.21e-29

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 115.62  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHggVICTQVHKQAVVQLALRVADEMDVNIGHE 141
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQ----YLLAAGFRH--IACTQPRRIACISLAKRVAFESLNQYGSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 142 VGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKD 221
Cdd:cd17979    75 VAYQIRFERTRTLATKLL------------------FLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRC 136

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1220237856 222 VLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17979   137 LLRLRPDLKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 62-235 4.37e-25

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 103.20  E-value: 4.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQ--WCAEYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVnIG 139
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQflYEAGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 HEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVL---- 215
Cdd:cd17982    80 KEVSYQIRYDSTVSENTKIK------------------FMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILigml 141

                         170       180
                  ....*....|....*....|....*..
gi 1220237856 216 -------LGLLKDVLLARPeLKLIINS 235
Cdd:cd17982   142 srivplrAKLYLQDQTVKP-LKLVIMS 167
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 476-565 4.79e-25

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 100.00  E-value: 4.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 476 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCF---SHVPHGAEEAALTCW 552
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqpNFLDPRSAAKAARRR 80

                          90       100
                  ....*....|....*....|....
gi 1220237856 553 KTFLHPE-----------GDHFTL 565
Cdd:pfam04408  81 RRAADEKarakfarldleGDHLTL 104
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 62-255 3.68e-24

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 99.91  E-value: 3.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCL-SIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17985    81 SVGYQIRLESVKSSATRLL------------------YCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLK 142

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17985   143 DLMVQRPDLKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 62-255 5.39e-24

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 99.45  E-value: 5.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHyqhgGVIC-TQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIR----GLIGhTQPRRLAARSVAERIAEELKTELGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17989    77 AVGYKVRFTDQTSDETCVK------------------LMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLK 138

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17989   139 QLLPRRPDLKVIITSATIDAERFSRHFNNAPIIEV 173
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 62-255 1.27e-23

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 98.33  E-value: 1.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAE-YCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGH 140
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 141 EVGYVIPFENCCTNetilrhsyfRCGGLkykgthgdRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLK 220
Cdd:cd17976    81 NVGYQVRLESRPPP---------RGGAL--------LFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLK 143

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1220237856 221 DVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17976   144 GVLQLNPELRVVLMSATGDNQRLSRYFGGCPVVRV 178
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 482-566 1.30e-22

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 92.33  E-value: 1.30e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  482 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFshvPHGAEEAALTCWKTFLHPEGD 561
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77


                   ....*
gi 1220237856  562 HFTLI 566
Cdd:smart00847  78 HLTLL 82
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 62-255 2.09e-22

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 94.91  E-value: 2.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHGG-----VICTQVHKQAVVQLALRVADEM-- 134
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQ----FILDDAIERGKgsscrIVCTQPRRISAISVAERVAAERae 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 135 DVNIGHEVGYVIPFENCCTNE--TILrhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIAT 212
Cdd:cd17981    77 SCGLGNSTGYQIRLESRKPRKqgSIL-------------------YCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQS 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1220237856 213 DVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17981   138 DVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 9-255 8.51e-22

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 94.90  E-value: 8.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856   9 PNSSPEKRYFPESldSSDGDEEEVLAC--EDLELNPFDGLPY----SSRYYKLLKEREDLPIWKEKYSFMEKLLQNQIVI 82
Cdd:cd17972     2 PWSPPQSNWNPWT--SSNIDEGPLAFAtpEQISMDLKNELMYqreqDHNLQQILQERELLPVKKFREEILEAISNNPVVI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  83 VSGDAKCGKSSQVPQWCA-EYCLSIHYQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFEncctneTILRHS 161
Cdd:cd17972    80 IRGATGCGKTTQVPQYILdDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFE------SVLPRP 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 162 YfrcGGLkykgthgdRYCTDDMLQREMMSnpflGSYGV--IILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHL 239
Cdd:cd17972   154 H---ASI--------LFCTVGVLLRKLEA----GIRGIshVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATID 218

                         250
                  ....*....|....*.
gi 1220237856 240 ISKLNSYYGNLPLIEV 255
Cdd:cd17972   219 TSMFCEYFFNCPVIEV 234
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 634-714 4.80e-21

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 87.69  E-value: 4.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 634 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGY-SVTKKMPEWVLFHQFSISENNYIRITSEISPELFMQLVP 712
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1220237856 713 QY 714
Cdd:pfam07717  81 HI 82
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 62-255 6.23e-21

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 90.66  E-value: 6.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYClsihYQHGG---VICTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDC----YANGIpcrIFCTQPRRLAAIAVAERVAAERGEKI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMS-NPFLGSYGVIILDDIHERSIATDVLLG 217
Cdd:cd17987    77 GQTVGYQIRLESRVSPKTLLT------------------FCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLT 138

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1220237856 218 LLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17987   139 KLRDILQKHPNLKLILSSAALDVNLFIRYFGSCPVIYI 176
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 127-533 5.70e-20

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 94.99  E-value: 5.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 127 ALRVADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIH 206
Cdd:PRK11664   65 AQRLAEQLGEKPGETVGYRMRAESKVGPNTRLE------------------VVTEGILTRMIQRDPELSGVGLVILDEFH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 207 ERSIATDVLLGLLKDVLLA-RPELKLIINSSPHLISKLNSYYGNLPLIEVKSK-HPVEVVYLSEAQKDSFE-----SILR 279
Cdd:PRK11664  127 ERSLQADLALALLLDVQQGlRDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRsFPVERRYQPLPAHQRFDeavarATAE 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 280 LIFEihrsgEKGDIVVFLACEQDIEKVYEivyqgsNLNPDLGELVVV-PLYPkekcSLfkPLDETEKKCQ---VYQRRVV 355
Cdd:PRK11664  207 LLRQ-----ESGSLLLFLPGVGEIQRVQE------QLASRVASDVLLcPLYG----AL--SLAEQQKAILpapAGRRKVV 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 356 LTTSSGESLIWSNSVKFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKdmTPLK 435
Cdd:PRK11664  270 LATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER--AAAQ 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 436 P-AEMQEANLTSMVLfmkriDIAGLGHCD-----FMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLS 509
Cdd:PRK11664  348 SePEILHSDLSGLLL-----ELLQWGCHDpaqlsWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA 422

                         410       420
                  ....*....|....*....|....
gi 1220237856 510 KSILASCEFDcvDEVLTIAAMVTA 533
Cdd:PRK11664  423 AMLVAAKEDD--EAALATAAKLAA 444
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 62-255 1.66e-19

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 86.89  E-value: 1.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQWCAEYCLSIHYQHG--GVICTQVHKQAVVQLALRVADEMDVNIG 139
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQkcNIVCTQPRRISAMSLATRVCEELGCESG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 140 -----HEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDV 214
Cdd:cd17975    81 pggknSLCGYQIRMESRTGEATRLL------------------YCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDF 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1220237856 215 LLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNLPLIEV 255
Cdd:cd17975   143 LLIILKEILHKRSDLHLILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 62-209 1.94e-13

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 69.07  E-value: 1.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  62 LPIWKEKYSFMEKLLQNQIVIVSGDAKCGKSSQVPQwcaeYCLSIHYQHG---GVICTQVHKQAVVQLALRVADEMDVNI 138
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQ----FILDHYYKRGkycNIVVTQPRRIAAISIARRVSQEREWTL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220237856 139 GHEVGYVIPFENCCTNETILRhsyfrcgglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERS 209
Cdd:cd17988    77 GSLVGYQVGLERPASEETRLI------------------YCTTGVLLQKLINNKTLTEYTHIILDEVHERD 129
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 90-255 1.60e-10

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 60.42  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856  90 GKSSQVP----QWCAEyclsihyQHGGVICTQVHKQAVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRhsyfrc 165
Cdd:cd17990    29 GKTTRVPlallAELWI-------AGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGRRTRVE------ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220237856 166 gglkykgthgdrYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLA-RPELKLIINSSPHLISKLN 244
Cdd:cd17990    96 ------------VVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAMSATLDGDGLA 163

                         170
                  ....*....|.
gi 1220237856 245 SYYGNLPLIEV 255
Cdd:cd17990   164 ALLPEAPVVES 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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