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Conserved domains on  [gi|1220148349|ref|XP_021797719|]
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phospholipid phosphatase 3 [Papio anubis]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 3.54e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 206.71  E-value: 3.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220148349 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384    80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 3.54e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 206.71  E-value: 3.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220148349 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384    80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
134-271 3.68e-32

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 115.52  E-value: 3.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  134 LFGCAISQSFTDIAKVSIGRLRPHFLSvcnpdfsqincsegyIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLY 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1220148349  214 LQARFTWRgarllrpLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:smart00014  66 LPARAGRK-------LLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
 49-273 4.96e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.14  E-value: 4.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  49 LPFLIIET--STIKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITGEFYriYYLKKSrstiqnpyVA 124
Cdd:PLN02250   30 LLLVVIEVvlNVIEPFHR-FVGKDmlTDLSYPLQD----NTIPFWAVPLIAILLPFAVILVY--YFIRRD--------VY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSM 204
Cdd:PLN02250   95 DLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPD--GKGVFHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1220148349 205 YTMLYLVLYLQAR---FTWRGaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA--CCIVFF 273
Cdd:PLN02250  173 AGLGFLSLYLSGKirvFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVAsfCYLQFF 245
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 132-274 8.33e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 8.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 132 CFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQIncsegyiqnyrcrgddSKVQEARKSFFSGHASFSMYTMLYLV 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP----------------STLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220148349 212 LYLQARFTWrgarlLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFV 274
Cdd:pfam01569  65 LLLRRLRKI-----VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 194-274 3.20e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 58.51  E-value: 3.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 194 SFFSGHASFSMytMLYLVLYLqarftwrgaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFF 273
Cdd:COG0671   118 SFPSGHAAAAF--ALALVLAL---------LLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                  .
gi 1220148349 274 V 274
Cdd:COG0671   187 L 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 3.54e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 206.71  E-value: 3.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220148349 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384    80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 72-272 9.82e-37

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 130.03  E-value: 9.82e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  72 SIKYPLKTGETINDAVLCAVGIVIAILAIItgefyrIYYLKKSRStIQNPYVAALykqvgCFLFGCAISQSFTDIAKVSI 151
Cdd:cd03390     2 SISYPFAESETVPTWLLVIISVGIPLLVII------LISLFFRRS-LWDLHTSLL-----GLLLSVSLNGVITNVLKNYA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 152 GRLRPHFLSVCNPDfsQINCSEGYIQNYRCR-GDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTW--RGARLLRP 228
Cdd:cd03390    70 GRPRPDFLARCFPD--GGTPSDTLVGIDICCtGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIfdPRGSSWRL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1220148349 229 LLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVF 272
Cdd:cd03390   148 LLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYR 191
acidPPc smart00014
Acid phosphatase homologues;
134-271 3.68e-32

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 115.52  E-value: 3.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  134 LFGCAISQSFTDIAKVSIGRLRPHFLSvcnpdfsqincsegyIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLY 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1220148349  214 LQARFTWRgarllrpLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:smart00014  66 LPARAGRK-------LLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 130-268 9.07e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 93.68  E-value: 9.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 130 VGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsqincsegyiqnyrcrGDDSKVQEARKSFFSGHASFSMYTMLY 209
Cdd:cd01610     5 ALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFALALF 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1220148349 210 LVLYLqarftwrGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVAC 268
Cdd:cd01610    68 LALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
PLN02250 PLN02250
lipid phosphate phosphatase
 49-273 4.96e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.14  E-value: 4.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  49 LPFLIIET--STIKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITGEFYriYYLKKSrstiqnpyVA 124
Cdd:PLN02250   30 LLLVVIEVvlNVIEPFHR-FVGKDmlTDLSYPLQD----NTIPFWAVPLIAILLPFAVILVY--YFIRRD--------VY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSM 204
Cdd:PLN02250   95 DLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPD--GKGVFHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1220148349 205 YTMLYLVLYLQAR---FTWRGaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA--CCIVFF 273
Cdd:PLN02250  173 AGLGFLSLYLSGKirvFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVAsfCYLQFF 245
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 132-274 8.33e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 8.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 132 CFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQIncsegyiqnyrcrgddSKVQEARKSFFSGHASFSMYTMLYLV 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP----------------STLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220148349 212 LYLQARFTWrgarlLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFV 274
Cdd:pfam01569  65 LLLRRLRKI-----VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02715 PLN02715
lipid phosphate phosphatase
 54-267 5.95e-18

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 82.79  E-value: 5.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  54 IETSTIKPYHRgfYCNDE---SIKYPLKTgetiNDAVLCAVGIVIAILAIITgefYRIYYLKKSrstiqnpYVAALYKQV 130
Cdd:PLN02715   62 IGLNLISPFYR--YVGKDmmtDLKYPFKD----NTVPIWSVPVYAVLLPIIL---FVCFYLKRR-------CVYDLHHSI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 131 GCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQnyrCRGDDSKVQEARKSFFSGHASFSMYTMLYL 210
Cdd:PLN02715  126 LGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVI---CHGKAAEVKEGHKSFPSGHTSWSFAGLTFL 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 211 VLYLQAR---FTWRGARLLRPLLQFTLiMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:PLN02715  203 SLYLSGKikaFNGEGHVAKLCLVIFPL-LAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 59-273 1.74e-16

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 78.53  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  59 IKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITgeFYRIYYLKKSrstiqnpyVAALYKQVGCFLFG 136
Cdd:PLN02731   61 IHPFYR-FVGKDmmTDLSYPLKS----NTVPIWSVPVYAMLLPLVI--FIFIYFRRRD--------VYDLHHAVLGLLYS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 137 CAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGyiqNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQA 216
Cdd:PLN02731  126 VLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLG---DVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSG 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1220148349 217 R---FTWRG--ARLLRPLLQftlIMMAFYTGLSRVSDHKHHPSDVLAGFAQG--ALVACCIVFF 273
Cdd:PLN02731  203 KiqaFDGKGhvAKLCIVILP---LLFAALVGISRVDDYWHHWQDVFAGGLLGlaISTICYLQFF 263
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 86-273 2.78e-13

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 66.86  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  86 AVLCAVGIVIAILAIITGEFYRIYYlkksrstiqnpYVAALYkqvgcFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPD 165
Cdd:cd03392    36 TFLGSPAVLLIIVLLLALLLLLKRR-----------RRAALF-----LLLALLGGGALNTLLKLLVQRPRPPLHLLVPEG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 166 fsqincseGYiqnyrcrgddskvqearkSFFSGHASFSMytMLYLVL-YLQARFTWRgaRLLRPLLQFTLIMMAFYTGLS 244
Cdd:cd03392   100 --------GY------------------SFPSGHAMGAT--VLYGFLaYLLARRLPR--RRVRILLLILAAILILLVGLS 149

                         170       180       190
                  ....*....|....*....|....*....|
gi 1220148349 245 RVSDHKHHPSDVLAGFAQG-ALVACCIVFF 273
Cdd:cd03392   150 RLYLGVHYPSDVLAGWLLGlAWLALLILLY 179
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 194-274 3.20e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 58.51  E-value: 3.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 194 SFFSGHASFSMytMLYLVLYLqarftwrgaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFF 273
Cdd:COG0671   118 SFPSGHAAAAF--ALALVLAL---------LLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                  .
gi 1220148349 274 V 274
Cdd:COG0671   187 L 187
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 133-267 1.55e-08

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 51.56  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 133 FLFGCAISQSFTDIAKVSIGRLRPhflsvcnpdfsqincsEGYIQNYRcrgddskvqearkSFFSGHAS--FSMYTMLyl 210
Cdd:cd03394     8 LAEAAALTAAVTEGLKFAVGRARP----------------DGSNNGYR-------------SFPSGHTAsaFAAATFL-- 56

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1220148349 211 vlylQARFTWRgarlLRPLLQFTLimmAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03394    57 ----QYRYGWR----WYGIPAYAL---ASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 90-267 1.32e-07

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 50.78  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349  90 AVGIVIAILAIitgefYRIYYLKKSRSTIQNPYVAALykqvGCFLFGC-AISQSFTDIAKVSIGRLRPHFLsvcnpdfsq 168
Cdd:cd03389    39 IPSLLLFLLFR-----FGDLRGLSAPSRARFPKAAWA----GLFLFATvALSGILVNLLKFIIGRARPKLL--------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 169 inCSEGYIQNYRCRGDDskvqeARKSFFSGHAS--FSMYTMLYLvLYLQARFTWRGARLLrpllqftlimmafyTGLSRV 246
Cdd:cd03389   101 --FDDGLYGFDPFHADY-----AFTSFPSGHSAtaGAAAAALAL-LFPRYRWAFILLALL--------------IAFSRV 158

                         170       180
                  ....*....|....*....|.
gi 1220148349 247 SDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03389   159 IVGAHYPSDVIAGSLLGAVTA 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 134-279 5.10e-07

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 48.80  E-value: 5.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220148349 134 LFGCAIS---QSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYiqnyrcrgddskvqearkSFFSGHASFSMYTMLYL 210
Cdd:cd03395    60 LVLLAVGfadQLASGFLKPLVARLRPCNALDGVRLVVLGDQGGSY------------------SFASSHAANSFALALFI 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220148349 211 VLYLQARFtwrgarllrplLQFTLIMMAFYTGLSRVSDHKHHPSDVLAgfaqGALVACCIVFFVSDLFK 279
Cdd:cd03395   122 WLFFRRGL-----------FSPVLLLWALLVGYSRVYVGVHYPGDVIA----GALIGIISGLLFYLLFS 175
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 194-265 1.93e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 44.23  E-value: 1.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1220148349 194 SFFSGHAS--FSMYTMLYLVLYLqarftwrgARLLRPLLqftlIMMAFYTGLSRVSDHKHHPSDVLAGFAQGAL 265
Cdd:cd03391    92 SFPSGHASraAFVARFLLNHLVL--------AVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYL 153
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 197-267 6.93e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 42.26  E-value: 6.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220148349 197 SGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03382    85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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