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Conserved domains on  [gi|1211453920|ref|XP_021511234|]
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pyrroline-5-carboxylate reductase 2 [Meriones unguiculatus]

Protein Classification

pyrroline-5-carboxylate reductase family protein( domain architecture ID 11417420)

pyrroline-5-carboxylate reductase family protein similar to pyrroline-5-carboxylate reductase that catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline

CATH:  1.10.3730.10|3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0004735|GO:0055129

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-268 6.38e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


:

Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 292.35  E-value: 6.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVlSAHKIIASSPemDLPTVSALR-RMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFIL 79
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSGV-PPEDIIVSDR--SPERLEALAeRYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  80 DEIGADVQDRHIVVSCAAGVTISSVEKKLmvfQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEAL---GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATI 239
Cdd:COG0345   157 VWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTI 236

                         250       260
                  ....*....|....*....|....*....
gi 1211453920 240 HALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:COG0345   237 AGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-268 6.38e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 292.35  E-value: 6.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVlSAHKIIASSPemDLPTVSALR-RMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFIL 79
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSGV-PPEDIIVSDR--SPERLEALAeRYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  80 DEIGADVQDRHIVVSCAAGVTISSVEKKLmvfQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEAL---GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATI 239
Cdd:COG0345   157 VWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTI 236

                         250       260
                  ....*....|....*....|....*....
gi 1211453920 240 HALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:COG0345   237 AGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 1-268 3.40e-95

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 282.62  E-value: 3.40e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEmDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILD 80
Cdd:PLN02688    1 FRVGFIGAGKMAEAIARGLVASGVVPPSRISTADDS-NPARRDVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADVQDRHIVVSCAAGVTISSVEKKLmvfqPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCT 160
Cdd:PLN02688   80 ELRPLLSKDKLLVSVAAGITLADLQEWA----GGRRVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIW 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 161 EVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIH 240
Cdd:PLN02688  156 VVDEKLLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIA 235

                         250       260
                  ....*....|....*....|....*...
gi 1211453920 241 ALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:PLN02688  236 GVHELEKGGFRAALMNAVVAAAKRSREL 263
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 21-267 8.64e-79

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 240.24  E-value: 8.64e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  21 AAGVLSAHKIIASSPeMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQDRHIVVSCAAGVT 100
Cdd:TIGR00112   3 KAGALAPYDIYVINR-SPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 101 ISSVEKKLMVFQPapkVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAY 180
Cdd:TIGR00112  82 LEKLSQLLGGTRR---VVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 181 AFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEA 260
Cdd:TIGR00112 159 VFLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEA 238


                  ....*..
gi 1211453920 261 SCIRTRE 267
Cdd:TIGR00112 239 AVRRSRE 245
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 164-267 3.67e-48

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 156.79  E-value: 3.67e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 164 EDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALH 243
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1211453920 244 FLESGGFRSLLINAVEASCIRTRE 267
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-268 6.38e-99

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 292.35  E-value: 6.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVlSAHKIIASSPemDLPTVSALR-RMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFIL 79
Cdd:COG0345     3 MKIGFIGAGNMGSAIIKGLLKSGV-PPEDIIVSDR--SPERLEALAeRYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  80 DEIGADVQDRHIVVSCAAGVTISSVEKKLmvfQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEAL---GGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATI 239
Cdd:COG0345   157 VWVDEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTI 236

                         250       260
                  ....*....|....*....|....*....
gi 1211453920 240 HALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:COG0345   237 AGLKVLEEGGLRAAVIEAVEAAAERSKEL 265
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 1-268 3.40e-95

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 282.62  E-value: 3.40e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEmDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILD 80
Cdd:PLN02688    1 FRVGFIGAGKMAEAIARGLVASGVVPPSRISTADDS-NPARRDVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADVQDRHIVVSCAAGVTISSVEKKLmvfqPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCT 160
Cdd:PLN02688   80 ELRPLLSKDKLLVSVAAGITLADLQEWA----GGRRVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIW 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 161 EVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIH 240
Cdd:PLN02688  156 VVDEKLLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIA 235

                         250       260
                  ....*....|....*....|....*...
gi 1211453920 241 ALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:PLN02688  236 GVHELEKGGFRAALMNAVVAAAKRSREL 263
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 1-268 1.03e-83

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 253.53  E-value: 1.03e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVlSAHKIIASSPemDLPTVSALR-RMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFIL 79
Cdd:PRK11880    3 KKIGFIGGGNMASAIIGGLLASGV-PAKDIIVSDP--SPEKRAALAeEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  80 DEIGADVQDrhIVVSCAAGVTISSVEKKLmvfQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:PRK11880   80 SELKGQLDK--LVVSIAAGVTLARLERLL---GADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFGKV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVE-EDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGAT 238
Cdd:PRK11880  155 VWVDdEKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGGTT 234

                         250       260       270
                  ....*....|....*....|....*....|
gi 1211453920 239 IHALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:PRK11880  235 IAALRVLEEKGLRAAVIEAVQAAAKRSKEL 264
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 21-267 8.64e-79

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 240.24  E-value: 8.64e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  21 AAGVLSAHKIIASSPeMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQDRHIVVSCAAGVT 100
Cdd:TIGR00112   3 KAGALAPYDIYVINR-SPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 101 ISSVEKKLMVFQPapkVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAY 180
Cdd:TIGR00112  82 LEKLSQLLGGTRR---VVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 181 AFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEA 260
Cdd:TIGR00112 159 VFLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEA 238


                  ....*..
gi 1211453920 261 SCIRTRE 267
Cdd:TIGR00112 239 AVRRSRE 245
PTZ00431 PTZ00431
pyrroline carboxylate reductase; Provisional
 1-268 1.28e-50

pyrroline carboxylate reductase; Provisional


Pssm-ID: 173621 [Multi-domain]  Cd Length: 260  Bit Score: 168.59  E-value: 1.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSP-EMDLPtvsalrrmgVNLTRSNKDTVRHSDVLFLAVKPHIIPFIL 79
Cdd:PTZ00431    4 IRVGFIGLGKMGSALAYGIENSNIIGKENIYYHTPsKKNTP---------FVYLQSNEELAKTCDIIVLAVKPDLAGKVL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  80 DEIgADVQDRHIVVSCAAGVTISSVEKklMVFQPApKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:PTZ00431   75 LEI-KPYLGSKLLISICGGLNLKTLEE--MVGVEA-KIVRVMPNTPSLVGQGSLVFCANNNVDSTDKKKVIDIFSACGII 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATI 239
Cdd:PTZ00431  151 QEIKEKDMDIATAISGCGPAYVFLFIESLIDAGVKNGLNRDVSKNLVLQTILGSVHMVKASDQPVQQLKDDVCSPGGITI 230

                         250       260
                  ....*....|....*....|....*....
gi 1211453920 240 HALHFLESGGFRSLLINAVEASCIRTREL 268
Cdd:PTZ00431  231 VGLYTLEKHAFKYTVMDAVESACQKSKSM 259
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 164-267 3.67e-48

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 156.79  E-value: 3.67e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 164 EDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALH 243
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1211453920 244 FLESGGFRSLLINAVEASCIRTRE 267
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
PRK07679 PRK07679
pyrroline-5-carboxylate reductase; Reviewed
 1-274 7.48e-46

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 181079 [Multi-domain]  Cd Length: 279  Bit Score: 156.85  E-value: 7.48e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILD 80
Cdd:PRK07679    4 QNISFLGAGSIAEAIIGGLLHANVVKGEQITVSNRSNETRLQELHQKYGVKGTHNKKELLTDANILFLAMKPKDVAEALI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADVQDRHIVVSCAAGVTISSVEKklmVFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCT 160
Cdd:PRK07679   84 PFKEYIHNNQLIISLLAGVSTHSIRN---LLQKDVPIIRAMPNTSAAILKSATAISPSKHATAEHIQTAKALFETIGLVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 161 EVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIH 240
Cdd:PRK07679  161 VVEEEDMHAVTALSGSGPAYIYYVVEAMEKAAKKIGLKEDVAKSLILQTMIGAAEMLKASEKHPSILRKEITSPGGTTEA 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1211453920 241 ALHFLESGGFRSLLINAVEASCIRTRELQSMADQ 274
Cdd:PRK07679  241 GIEVLQEHRFQQALISCITQATQRSHNLGKTLEQ 274
PRK07680 PRK07680
late competence protein ComER; Validated
 1-254 7.04e-22

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 92.73  E-value: 7.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILD 80
Cdd:PRK07680    1 MNIGFIGTGNMGTILIEAFLESGAVKPSQLTITNRTPAKAYHIKERYPGIHVAKTIEEVISQSDLIFICVKPLDIYPLLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADVQDRHIVVSCAAGVTISSVEKKLmvfqP--APKVIRCMTNTpvvVREGATVYATGTHALVEDGKLLEQLMSSVGF 158
Cdd:PRK07680   81 KLAPHLTDEHCLVSITSPISVEQLETLV----PcqVARIIPSITNR---ALSGASLFTFGSRCSEEDQQKLERLFSNIST 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 159 CTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKM-GVPRRLAVRLGAQALLGAAKmLLDSEDH-PGQLKDNVCSPGG 236
Cdd:PRK07680  154 PLVIEEDITRVSSDIVSCGPAFFSYLLQRFIDAAVEEtNISKEEATTLASEMLIGMGK-LLEKGLYtLPTLQEKVCVKGG 232

                         250       260
                  ....*....|....*....|.
gi 1211453920 237 ATIHALHFLES---GGFRSLL 254
Cdd:PRK07680  233 ITGEGIKVLEEevgDMFHRLF 253
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
4-98 3.01e-17

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 75.35  E-value: 3.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   4 GFIGAGQLACALARGFTAAGvlsAHKI-IASSPEMDLpTVSALRRMGVNLT-RSNKDTVRHSDVLFLAVKPHIIPFILDE 81
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAG---PHEVvVANSRNPEK-AEELAEEYGVGATaVDNEEAAEEADVVFLAVKPEDAPDVLSE 76

                          90
                  ....*....|....*..
gi 1211453920  82 IgADVQDRHIVVSCAAG 98
Cdd:pfam03807  77 L-SDLLKGKIVISIAAG 92
PRK06928 PRK06928
pyrroline-5-carboxylate reductase; Reviewed
 3-238 3.98e-12

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235888 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   3 VGFIGAGQLACALARGFTAAGVLSAHKI-IASSPEMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKP-HIIPfILD 80
Cdd:PRK06928    4 IGFIGYGSMADMIATKLLETEVATPEEIiLYSSSKNEHFNQLYDKYPTVELADNEAEIFTKCDHSFICVPPlAVLP-LLK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADVQ-DRHiVVSCAAGVTISsvekKLMVFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFC 159
Cdd:PRK06928   83 DCAPVLTpDRH-VVSIAAGVSLD----DLLEITPGLQVSRLIPSLTSAVGVGTSLVAHAETVNEANKSRLEETLSHFSHV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 160 TEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMG-VPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGAT 238
Cdd:PRK06928  158 MTIREENMDIASNLTSSSPGFIAAIFEEFAEAAVRNSsLSDEEAFQFLNFALAGTGKLLVEEDYTFSGTIERVATKGGIT 237
PRK06476 PRK06476
pyrroline-5-carboxylate reductase; Reviewed
 1-266 9.98e-10

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235812 [Multi-domain]  Cd Length: 258  Bit Score: 58.10  E-value: 9.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFtAAGVLSAHKIIASSPEMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPhiipfild 80
Cdd:PRK06476    1 MKIGFIGTGAITEAMVTGL-LTSPADVSEIIVSPRNAQIAARLAERFPKVRIAKDNQAVVDRSDVVFLAVRP-------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920  81 EIGADV------QDRHIVVSCAAGVTISSVEKKLmvfQPAPKVIRCMTNTPVVVREGAT-VYAtgTHALVEDgkLLEQLM 153
Cdd:PRK06476   72 QIAEEVlralrfRPGQTVISVIAATDRAALLEWI---GHDVKLVRAIPLPFVAERKGVTaIYP--PDPFVAA--LFDALG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920 154 SSVGFCTEVEEDLIDAITGLsgSGPAYAFMalDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHP-GQLKDNVC 232
Cdd:PRK06476  145 TAVECDSEEEYDLLAAASAL--MATYFGIL--ETATGWLEEQGLKRQKARAYLAPLFASLAQDAVRSTKTDfSALSREFS 220

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1211453920 233 SPGGATIHALHFLESGGFRSLLINAVEASCIRTR 266
Cdd:PRK06476  221 TKGGLNEQVLNDFSRQGGYAALTDALDRVLRRIN 254
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-96 4.34e-06

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 46.70  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   3 VGFIGAGQLACALARGFTAAGvlsaHK-IIAS-SPEmdlpTVSAL-RRMGVNLT-RSNKDTVRHSDVLFLAVKPHIIPFI 78
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAG----HEvVIGSrDPE----KAAALaAELGPGARaGTNAEAAAAADVVVLAVPYEAVPDV 72

                          90
                  ....*....|....*...
gi 1211453920  79 LDEIGADVQDRhIVVSCA 96
Cdd:COG2085    73 LESLGDALAGK-IVIDAT 89
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 1-114 1.67e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 45.57  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGV-LSAhkIIASSPEmdlptvSALR---RMGVNLTRSNKDTVRHSDVLFLAVKPHIIP 76
Cdd:COG5495     4 MKIGIIGAGRVGTALAAALRAAGHeVVG--VYSRSPA------SAERaaaLLGAVPALDLEELAAEADLVLLAVPDDAIA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1211453920  77 FILDEIGA--DVQDRHIVVSCAAGVTISsvekklmVFQPA 114
Cdd:COG5495    76 EVAAGLAAagALRPGQLVVHTSGALGSD-------VLAPA 108
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 1-92 5.94e-03

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 37.80  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211453920   1 MSVGFIGAGQLACALARGFTAAGVlsAHKIIASSPemDLPTVSALRRMGV--NLTRSNKDTVRHSDVLFLAVKPHIIPFI 78
Cdd:COG0287     2 MRIAIIGLGLIGGSLALALKRAGL--AHEVVGVDR--SPETLERALELGVidRAATDLEEAVADADLVVLAVPVGATIEV 77

                          90
                  ....*....|....
gi 1211453920  79 LDEIGADVQDRHIV 92
Cdd:COG0287    78 LAELAPHLKPGAIV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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