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Conserved domains on  [gi|1211332832|ref|XP_021446180|]
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alpha-2,8-sialyltransferase 8E isoform X7 [Oncorhynchus mykiss]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 104-375 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467718  Cd Length: 273  Bit Score: 562.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 104 ETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKC 183
Cdd:cd23990     2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 184 GKDIDSADFVFRCNIPPINEKYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVS 263
Cdd:cd23990    82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 264 FRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYY 343
Cdd:cd23990   162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1211332832 344 DNVKPRPGFHAMPHEIFNFMHMHTRGILNVHS 375
Cdd:cd23990   242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 104-375 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 562.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 104 ETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKC 183
Cdd:cd23990     2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 184 GKDIDSADFVFRCNIPPINEKYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVS 263
Cdd:cd23990    82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 264 FRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYY 343
Cdd:cd23990   162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1211332832 344 DNVKPRPGFHAMPHEIFNFMHMHTRGILNVHS 375
Cdd:cd23990   242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 123-370 8.66e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 265.62  E-value: 8.66e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 123 FTTKRNTPAGTKLRYEvDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPIn 202
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 203 EKYSADVGAKTDLVTINP-SIITERFQKL--EKWRRPFYEVLQNYE--NSSVVLPAFYNTRNTDVSFRVKYMLDDFDSQR 277
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 278 G---VFFFHPQYLLNVQRFWT-VQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSgifITHHYYDNVKPRP--- 350
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 1211332832 351 -GFHAMPHEIFNFMHMHTRGI 370
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 104-375 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 562.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 104 ETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKC 183
Cdd:cd23990     2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 184 GKDIDSADFVFRCNIPPINEKYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVS 263
Cdd:cd23990    82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 264 FRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYY 343
Cdd:cd23990   162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1211332832 344 DNVKPRPGFHAMPHEIFNFMHMHTRGILNVHS 375
Cdd:cd23990   242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 104-374 1.91e-158

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 445.93  E-value: 1.91e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 104 ETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKC 183
Cdd:cd23971     2 EHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 184 GKDIDSADFVFRCNIPPINekYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVS 263
Cdd:cd23971    82 GREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 264 FRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYY 343
Cdd:cd23971   160 LRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYY 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1211332832 344 DNVKPRPGFHAMPHEIFNFMHMHTRGILNVH 374
Cdd:cd23971   240 DNVLPKKGVHAMPEEFLRYLKLHSQGVLRLH 270
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 104-371 1.51e-123

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 357.53  E-value: 1.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 104 ETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKC 183
Cdd:cd23991     2 EHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 184 GKDIDSADFVFRCNIPPINEKYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVS 263
Cdd:cd23991    82 GAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 264 FRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYY 343
Cdd:cd23991   162 FKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYY 241

                         250       260
                  ....*....|....*....|....*...
gi 1211332832 344 DNVKPRPGFHAMPHEIFNFMHMHTRGIL 371
Cdd:cd23991   242 DNQLPKPGFHSMPKEFYQLLQLHSKGIL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 108-374 1.13e-102

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 304.45  E-value: 1.13e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 108 FKMSLSRCCNAPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYsKSQFKKCAVVGNGGIIKNSKCGKDI 187
Cdd:cd23989     6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 188 DSADFVFRCNIPPINEKYSADVGAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVSFRVK 267
Cdd:cd23989    85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 268 YMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK 347
Cdd:cd23989   165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVL 244

                         250       260
                  ....*....|....*....|....*..
gi 1211332832 348 PRPGFHAMPHEIFNFMHMHTRGILNVH 374
Cdd:cd23989   245 PDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 123-370 8.66e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 265.62  E-value: 8.66e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 123 FTTKRNTPAGTKLRYEvDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPIn 202
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 203 EKYSADVGAKTDLVTINP-SIITERFQKL--EKWRRPFYEVLQNYE--NSSVVLPAFYNTRNTDVSFRVKYMLDDFDSQR 277
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 278 G---VFFFHPQYLLNVQRFWT-VQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSgifITHHYYDNVKPRP--- 350
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 1211332832 351 -GFHAMPHEIFNFMHMHTRGI 370
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 112-374 8.85e-88

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 266.43  E-value: 8.85e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 112 LSRCCNaPSFLFTTKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSAD 191
Cdd:cd23963    10 LERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 192 FVFRCNIPPInEKYSADVGAKTDLVTINPSIITERFQKL--EKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVSFRVKYM 269
Cdd:cd23963    89 FVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAARA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 270 LDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRaKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPR 349
Cdd:cd23963   168 LKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDLSPS 246

                         250       260
                  ....*....|....*....|....*...
gi 1211332832 350 P--GFHAMPHEiFNFMH-MHTRGILNVH 374
Cdd:cd23963   247 TknKVHNMPEE-FKLLReLHKKGVLKLH 273
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 101-374 5.85e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 198.00  E-value: 5.85e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 101 NMVETNNFKMSLSRCCNAPSFLFTTKRNTPAGTKLRYevDTSG---ILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGI 177
Cdd:cd23970     2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHF--DYSShkyVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 178 IKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINPSIITERFQKL--EKWRRPFYEVLQNYENSSVVLPAFY 255
Cdd:cd23970    80 LTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSILEKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 256 NTRNTDVSFRVKYMLDDFDSQRGVFFFHP-QYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPS 334
Cdd:cd23970   159 FHTSATVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1211332832 335 GIFITHHYYD------NVKPRPgFHAMPHEIFNFMHMHTRGILNVH 374
Cdd:cd23970   239 GTPLPYHYYDkkgtkfTTKWQE-SHQLPAEFVLLYKMHGAGVLKLT 283
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 125-375 3.48e-58

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 190.32  E-value: 3.48e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 125 TKRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEK 204
Cdd:cd23969    23 LKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 205 YSADVGAKTDLVTINPSIITERFQKL--EKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVSFRVKYMLDDFDSQRGVFFF 282
Cdd:cd23969   102 YEKDVGTKSNLTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTNEIILKHKLNVKTAYP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 283 HPQYLLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPR--PGFHAMPHEIF 360
Cdd:cd23969   182 PLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKYLttARPHKMPEEFR 261

                         250
                  ....*....|....*
gi 1211332832 361 NFMHMHTRGILNVHS 375
Cdd:cd23969   262 ALRSLHQRGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 132-374 8.38e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 184.37  E-value: 8.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 132 GTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINEkYSADVGA 211
Cdd:cd23987    30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 212 KTDLVTINPSIITERFQKL--EKWRRPFYEVLQNYENSSVVLPAFYNTRNTDvsfRVKYMLDDFDSQR-GVFFFHP--QY 286
Cdd:cd23987   109 KTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDLILKHHiNVRTAYPslRL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 287 LLNVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPHEIFNF 362
Cdd:cd23987   186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 265

                         250
                  ....*....|..
gi 1211332832 363 MHMHTRGILNVH 374
Cdd:cd23987   266 KNLHQQGALKLT 277
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 126-373 6.99e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 171.68  E-value: 6.99e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 126 KRNTPAGTKLRYEVDTSGILPISTEVFKMFPDDMPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINEkY 205
Cdd:cd23988    24 KSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-F 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 206 SADVGAKTDLVTINPSIITERFQKL--EKWRRPFYEVLQNYENSSVVLPAFYNTRNTDVSFRVKYMLddFDSQRGVFFFH 283
Cdd:cd23988   103 AADVGTKSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALI--LKNKLKVRTAY 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 284 PQYLL--NVQRFWTVQGVRAKRLSSGLMLVTAAMELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPR----PGFHAMPH 357
Cdd:cd23988   181 PSLRLihAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPL 260

                         250
                  ....*....|....*.
gi 1211332832 358 EIFNFMHMHTRGILNV 373
Cdd:cd23988   261 EFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 169-365 3.42e-31

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 117.08  E-value: 3.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 169 CAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINPSIiterFQKLEKWRRPFYEVLQNYENSS 248
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 249 VVLpafyntrntdvsFRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAK-------------RLSSGLMLVTAAM 315
Cdd:cd19952    76 LIL------------SRAAAADFKRLKRRKKRHDNAVLLLTDPAPDLLSYVRKRleklglksffggnAPSSGLLAVLLAL 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1211332832 316 ELCEEVHLYGFWAFPMNPSGIFitHHYYDNVKPRPG--FHAMPHEIFNFMHM 365
Cdd:cd19952   144 QLCDSVDLYGFGVDSGHAPKVP--YHYYDLVEAEEGtaVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 152-375 2.19e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.95  E-value: 2.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 152 FKMFPDDMPYSK---SQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTdlvtinpsiiTERFQ 228
Cdd:cd23966    60 FQVVPGENPYRTrdpNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKT----------THHFM 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 229 KLEKWRRpfyevLQNyENSSVVLP-----------AFYNTRNTDVSFRVKYMLD-DFDSqrgVFFFHPQYLLNVQRFWTV 296
Cdd:cd23966   129 YPESAVD-----LDP-GVHLVLVPfkvldlqwlisALTTGEITRTYTPVKRFIKaDKDK---VLVINPAFIKYVHDNWTE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 297 QgvRAKRLSSGLMLVTAAMELCEEVHLYGFWAfpmNPSGIFitHHYYDN-----VKPRPGFHAMPHEIFNFMHMHTRGIL 371
Cdd:cd23966   200 H--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKnrsagAFRKTGVHDADFESDIIKKLAKEGKI 272


                  ....
gi 1211332832 372 NVHS 375
Cdd:cd23966   273 RVYR 276
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 167-364 1.23e-18

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 83.11  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINPSIITerfqklekwRRPfyevLQNYEN 246
Cdd:cd23967     3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKTTFRMFYPESAF---------RDP----EEYDSD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 247 SSVVLPAFyntRNTDVSFrVKYMLDDFDSQRGVFFF-----------------HPQYL----LNVQRFWTVQGVRAKRLS 305
Cdd:cd23967    69 WLLVLVPF---KSMDLLW-LQAVIKGKKPNGKGGFWkkiatsvpkppkkirilNPYILqeaaFDLIGLPMNGKQGKNVPT 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1211332832 306 SGLMLVTAAMELCEEVHLYGFWAFPMNPSgifITHHYYDNVKprpgfhaMPHEIFNFMH 364
Cdd:cd23967   145 TGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT-------MKAIKRSWTH 193
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 166-347 1.68e-18

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 84.24  E-value: 1.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 166 FKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINPSIITERFQKLekWRRPFyevlqnYE 245
Cdd:cd23968    45 YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTTLRLINSQILSKPEFNF--LTDPL------YR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 246 NSSVVL--PAFYNTRNTDVSFRVKYMLDD--------FDSQRgVFFFHPQYLLnvqRFWTV-QGVRAKRL-----SSGLM 309
Cdd:cd23968   116 NVTLLVwdPSSYNVNLEKWYKKPDFDFFPnyikyrrrHPEEP-FYLIDPRFLW---RLWDIlQEYTPEKIkpnppSSGFI 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1211332832 310 LVTAAMELCEEVHLYGFWafpmnPSgIFITH--HYYDNVK 347
Cdd:cd23968   192 GIVLMLHLCDWVDVYEYV-----PS-VRQTDrcHYYDVEK 225
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 168-374 7.84e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 82.69  E-value: 7.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 168 KCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINEKYSaDVGAKTDLVTINPSIITERFQKlekwrrpfyEVLQNYENS 247
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK-DVGTKTSFYTFFPESLHNSLLK---------HVPQDKDTK 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 248 SVVLPafYNTRntDVSF--------RVKYMLDDFDSQRGVF----------FFHPQYLLNVQRFWtVQGVRAKRLSSGLM 309
Cdd:cd23964   154 YLFIP--FKIR--DYDYldavlsgkPVPDGCDKGKRPPPLFgpklnatnvrLLHPDFIRYLFNRW-LNSSTSYRPTTGAL 228

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1211332832 310 LVTAAMELCEEVHLYGF---WAFPMnpsgifithHYYDN----VKPRPGFHAMPHEIFNFMHMHTRGILNVH 374
Cdd:cd23964   229 MLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLY 291
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 146-326 7.79e-17

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 79.37  E-value: 7.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 146 PISTEVFKMFP------DDMPYSKS------QFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKT 213
Cdd:cd23985    13 NVSMLEGTDFPfntsewEGYLPKKSlreevgPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT-AGFQQDVGTKT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 214 DLVTINPSII-TERFQKLEKwrrPFYEvlqnyENSSVVL-PAFYNT------RNTDVSFrvkymLDDFDSQRGVFFFHPQ 285
Cdd:cd23985    92 TIRLINSQLVtTEKHKFLKD---SLYN-----EGILIVWdPAPYHSdipewyKNPDYNF-----FENYKTYRRLNPNQPF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1211332832 286 YLLNVQRFWT----VQGVRAKRL-----SSGLMLVTAAMELCEEVHLYGF 326
Cdd:cd23985   159 YILHPQMQWElwdiIQENSPEEIqpnppSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 154-374 1.04e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 77.10  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 154 MFPDDM-PYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINeKYSADVGAKTDLVTINPSIITER------ 226
Cdd:cd23974    71 MFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITK-GFEKDVGRRTSFYTFSTNTLMNSlrayag 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 227 --FQKLEKWRRPFYEVLQNYENSSVVLPAFYN----TRNTDVSFR-VKYMLDDFDSQRgVFFFHP---QYLLNvqRFWTV 296
Cdd:cd23974   150 vgFNGPPQSKETRYIFLPDHDRDYLLVKAALThtpiDRGRDKSKRpSKYFGKDVTAEK-FKIYHPdfiRYLRN--RFLWS 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 297 QGVRAK-----RLSSGLMLVTAAMELCEEVHLYGFwafpMNPSGIFITHHYYDNVKPRPGF---HAMPHEIFNFMHMHTR 368
Cdd:cd23974   227 PILNTKqrdiyRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKA 302


                  ....*.
gi 1211332832 369 GILNVH 374
Cdd:cd23974   303 GLIKLY 308
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 134-345 1.16e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 76.46  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 134 KLRYEVDTSGILPISTEVFKMFPDDMP--YSKSQF--KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADV 209
Cdd:cd23980    45 RLQREKKPKNLNDTIRELFQVVPGNVDplLEKRLVscRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 210 GAKTDLVTINPSIITERFQKLEKWRRPFYEVLQNYENSSVVLPAFYNTRnTDVSFRVKYmlddfdSQRGVFFFHPQYLLN 289
Cdd:cd23980   124 GSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVISATTTGTISHTY-VPVPRKIKV------KKEKILIYHPAFIKY 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1211332832 290 VQRFWtVQGvRAKRLSSGLMLVTAAMELCEEVHLYGFWAfpmNPSGIFitHHYYDN 345
Cdd:cd23980   197 VFDRW-LQG-HGRYPSTGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 159-376 3.97e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 75.17  E-value: 3.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 159 MPYSKSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINeKYSADVGAKTDLVTINPSIITERFQKLEKwrRPFY 238
Cdd:cd23973    76 SPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIK-GYEEDVGTRTSFYVHTAHSITSSLMILQK--RGFK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 239 EVLQNYENSSVVLPAF---YN-----TRNTDVS----FRV---KYMLDDFDSQRgVFFFHPQYLLNVQ-RFW---TVQGV 299
Cdd:cd23973   153 NIPQDKDIKYILFPEGprdYQwlealLKNKTIPsgayYGRrprSYFSGDFTEDK-YLVLHPDFLRYVKnRFLrskTLKGK 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 300 --RAKRLSSGLMLVTAAMELCEEVHLYGFwafpMNPSGIFITHHYYDNVKPRPGF---HAMPHEIFNFMHMHTRGILNVH 374
Cdd:cd23973   232 ywAIYRPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKLY 307


                  ..
gi 1211332832 375 SG 376
Cdd:cd23973   308 QR 309
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 167-346 2.08e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 68.54  E-value: 2.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINEkYSADVGAKTDL-------VTINPSI--------ITERFQKLE 231
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIrlfypesAQFDPGIendpdtllVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 232 -KWrrpFYEVLQNyenssvvlpafyNTRNTDVSFRVKYMLDDFDSQRgVFFFHPQY-------LLNVqrfwTVQGVRAKR 303
Cdd:cd23982    82 fYW---LYEILSN------------EKRVRKGFWKQPPRIWDANPKQ-IRILNPYYtyvaatkLLQV----PGQRKKKQK 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1211332832 304 LSSGLMLVTAAMELCEEVHLYGFwAFPMN-PSGIFIthHYYDNV 346
Cdd:cd23982   142 PTTGLLAITLALHLCDEVHIAGF-GYPDNgNSNQPI--HYYNQI 182
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 153-326 2.28e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.48  E-value: 2.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 153 KMFPDdMPYSKSQ---FKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADVGAKTDLVTINPSIIT---ER 226
Cdd:cd23986    34 KYVPK-IPLSKLHlrgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTnpnHH 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 227 FQK--------LEKWR-RPFYEVLQNYENSsvvlPAfYNTRNTDVSFRVKYMLDDFdsqrgvFFFHPQY---LLNVQRFW 294
Cdd:cd23986   112 FIDsslykdviLVAWDpAPYSANLHKWYKK----PD-YNLFTPYVQYRKRNPNQPF------YILHPKFiwqLWDIIQEN 180

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1211332832 295 TVQGVRAKRLSSGLMLVTAAMELCEEVHLYGF 326
Cdd:cd23986   181 TQEKIQPNPPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 167-344 5.97e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 67.65  E-value: 5.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDL-VTINPSIITERFQKlekwrrpfYEVLQNYE 245
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIrVVSHSSLPRLLRNA--------ILLLAGTR 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 246 NSSVVLPAFYNT-RNTDVSFRVKYMLDDFDSQRGVFFFHP---QYLLNVQRFWTVQGV-RAKR---LSSGLMLVTAAMEL 317
Cdd:cd23965    73 APTVVVFWGPETkMNKDGAGKYNLLRSLSKKYPDVEFYSLtpeKMDYADELFEKETGKsRIKSgtwLSTGWFTMLLALDV 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1211332832 318 CEEVHLYGfwafpMNPSGIFITH-------HYYD 344
Cdd:cd23965   153 CDEIKVYG-----MVPENYCREHpnskvpyHYYE 181
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 168-374 6.09e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 68.70  E-value: 6.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 168 KCAVVGNGGIIKNSKCGKDIDSADFVFRCNiPPINEKYSADVGAKTDL--VTINpsiiTERFQKLEKWRRPFYEVLQNYE 245
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVN----TMKNSLISYWNLGFTRTPQGQD 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 246 NSSVVLPA----FYNTRNTDVSFRVKYMLDDFDSQRGVF----------FFHPQYLlnvqRFWTVQGVRAKRL------- 304
Cdd:cd23972   159 LQYIFIPSdirdYVMLRSAILGVPVPEGLDKGDRPHKYFgpeasakkfkLLHPDFI----SYLTDRFLKSKLLnthyghl 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 305 ----SSGLMLVTaAMELCEEVHLYGF-----WAFpmnpsgifiTHHYYDNVKPRPGF---HAMPHEIFNFMHMHTRGILN 372
Cdd:cd23972   235 ympsTGALMLLT-ALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGILQ 304


                  ..
gi 1211332832 373 VH 374
Cdd:cd23972   305 LY 306
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 167-346 2.59e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 62.46  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPINeKYSADVGAKTDLVTINPSIIterfqklekwrrpFYEVLQNYEN 246
Cdd:cd23984     3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPESI-------------FSDPSHYDPN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 247 SSVVLPAFyntRNTDVSFRVKYMLDDFDSQRGvFFFHP----QYLLNVQRFWTVQGVR------------------AKRL 304
Cdd:cd23984    69 TTVVLIPF---KPHDLRWLLDLLMGKKVSAKG-FWKKPalnlIYKPNQIRILNPFILRiaayellhfpkrfpkekkPKHP 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1211332832 305 SSGLMLVTAAMELCEEVHLYGfwaFPMNPSGIFITHHYYDNV 346
Cdd:cd23984   145 TTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 147-345 1.21e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.73  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 147 ISTEVFKMFPDDMPYS---KSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADVGAKTdlvtinpsii 223
Cdd:cd23979    58 VLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRT---------- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 224 TERFQklekwrrpFYEVLQNY-ENSSVVLPAF-----------YNTRNTDVSFR-VKYMLdDFDSQRgVFFFHPQYLLNV 290
Cdd:cd23979   127 THHFM--------YPESAKNLpANVSFVLVPFktldllwitsaLSTGQIRFTYApVKQFL-RVDKDK-VQIYNPAFFKYI 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1211332832 291 QRFWTVQGVRAKrlSSGLMLVTAAMELCEEVHLYGFWAfpmNPSGIFitHHYYDN 345
Cdd:cd23979   197 HDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 167-346 6.97e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 55.51  E-value: 6.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINP-------------------------- 220
Cdd:cd23983     3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPegapkseqeydptslfvavlfksvdf 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 221 ----SIITErfQKLEKWRRPFYevLQNYENSSVVLPAFYNTRNTDVsfrVKYMLDDFDSqrgvfFFHPQyllnvQRFWtv 296
Cdd:cd23983    82 awlkAMVKK--EPLSFWSRLFF--WKEVADSIPLKPSQFRILNPLI---IKETALDILQ-----YPEPQ-----SRLW-- 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1211332832 297 qGVRAKRLSSGLMLVTAAMELCEEVHLYGFwAFPMNPSGIFIthHYYDNV 346
Cdd:cd23983   143 -GWDKNVPTLGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 167-232 1.58e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.16  E-value: 1.58e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPInEKYSADVGAKTDLVTINPSIITERFQKLEK 232
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQKPEQYEK 67
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 163-358 2.49e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.33  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 163 KSQFKKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADVGAKTDLVTINPSIIterfQKLEKWRrpfYEVLQ 242
Cdd:cd23976    12 KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLRVIAHSSI----QRILRNR---NELLN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 243 NYENSSVVL--PAFYNTRN-TDVSFRVKYMLDDFDSQRGVFFFHPQYLLNVQRFWTVQGVRAKR-----LSSGLMLVTAA 314
Cdd:cd23976    84 VSQGTVFIFwgPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKisntwLSTGWFTMIIA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1211332832 315 MELCEEVHLYGFWA--FPMNPSGIFITHHYYDNVKPRPGFHAMPHE 358
Cdd:cd23976   164 LELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGPDECTMYISHE 209
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 167-344 4.34e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 47.55  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 167 KKCAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADVGAKTDLVTIN----PSIITERFQKLEKWRRPFYEVLQ 242
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 243 NYENSSVVLPAfyNTRNTDVSFRVKYmlddfdsqrgvfffhPQ---YLLNVQRFWTVQGV--------RAKR---LSSGL 308
Cdd:cd23977    81 PERNMDRDGGG--KTYRALLTLAKMY---------------PHlqvYTLTEEKMAYCDGVfqnetgknRMKSgsfLSTGW 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1211332832 309 MLVTAAMELCEEVHLYGFW--AFPMNPSGIFITHHYYD 344
Cdd:cd23977   144 FTMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 169-344 1.26e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 46.08  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 169 CAVVGNGGIIKNSKCGKDIDSADFVFRCNIPPiNEKYSADVGAKTDLVTINPSIITERFQKlekwrrPFYEVLQNYENSS 248
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVVSHTSVPLLLKN------PDYFFKETNETIY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1211332832 249 VVLPAFYNTRNtDVSFRVKYMLddfdsqRGVFFFHPQ---YLLNVQRFWTVQGVRAK-----RLSSGLMLVTA------A 314
Cdd:cd23975    77 VIWGPFRNMRK-DGKGIVYNML------KKAVESYPQakiYVTTEKRMSYCDTVFKKetgkdRVQSGSYLSTGwftlilA 149

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1211332832 315 MELCEEVHLYGFWAFPMNPSGIF--ITHHYYD 344
Cdd:cd23975   150 MDACYGIHVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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