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neuralized-like protein 4 isoform X2 [Danio rerio]
SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)
SPRY_NHR_like domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
553-713 | 2.18e-85 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 275.54 E-value: 2.18e-85
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
752-914 | 4.83e-84 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 271.69 E-value: 4.83e-84
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
4-166 | 1.68e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.98 E-value: 1.68e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
347-509 | 2.65e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.21 E-value: 2.65e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
1158-1317 | 9.61e-77 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 250.89 E-value: 9.61e-77
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
946-1112 | 4.09e-65 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. : Pssm-ID: 293945 Cd Length: 161 Bit Score: 217.76 E-value: 4.09e-65
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Name | Accession | Description | Interval | E-value | ||||
SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
553-713 | 2.18e-85 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 275.54 E-value: 2.18e-85
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
752-914 | 4.83e-84 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 271.69 E-value: 4.83e-84
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
4-166 | 1.68e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.98 E-value: 1.68e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
347-509 | 2.65e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.21 E-value: 2.65e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
1158-1317 | 9.61e-77 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 250.89 E-value: 9.61e-77
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
946-1112 | 4.09e-65 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 217.76 E-value: 4.09e-65
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
347-509 | 1.01e-56 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 193.13 E-value: 1.01e-56
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
553-715 | 4.10e-55 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 188.51 E-value: 4.10e-55
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
753-915 | 3.72e-52 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 180.04 E-value: 3.72e-52
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
6-167 | 1.75e-51 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 178.11 E-value: 1.75e-51
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
1159-1317 | 7.19e-45 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 159.24 E-value: 7.19e-45
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NEUZ | smart00588 | domain in neuralized proteins; |
343-467 | 1.45e-44 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 157.47 E-value: 1.45e-44
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
948-1113 | 1.61e-40 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 146.91 E-value: 1.61e-40
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NEUZ | smart00588 | domain in neuralized proteins; |
549-672 | 5.49e-40 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 144.38 E-value: 5.49e-40
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NEUZ | smart00588 | domain in neuralized proteins; |
750-872 | 1.43e-31 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 120.11 E-value: 1.43e-31
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NEUZ | smart00588 | domain in neuralized proteins; |
6-124 | 5.46e-31 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 118.57 E-value: 5.46e-31
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NEUZ | smart00588 | domain in neuralized proteins; |
946-1070 | 8.01e-17 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 78.12 E-value: 8.01e-17
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NEUZ | smart00588 | domain in neuralized proteins; |
1163-1272 | 8.63e-11 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 60.79 E-value: 8.63e-11
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Name | Accession | Description | Interval | E-value | ||||
SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
553-713 | 2.18e-85 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 275.54 E-value: 2.18e-85
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
752-914 | 4.83e-84 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 271.69 E-value: 4.83e-84
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
4-166 | 1.68e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.98 E-value: 1.68e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
347-509 | 2.65e-79 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 258.21 E-value: 2.65e-79
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
1158-1317 | 9.61e-77 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 250.89 E-value: 9.61e-77
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SPRY_NHR_like | cd12887 | SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ... |
946-1112 | 4.09e-65 | ||||
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family. Pssm-ID: 293945 Cd Length: 161 Bit Score: 217.76 E-value: 4.09e-65
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
347-509 | 1.01e-56 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 193.13 E-value: 1.01e-56
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
553-715 | 4.10e-55 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 188.51 E-value: 4.10e-55
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
753-915 | 3.72e-52 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 180.04 E-value: 3.72e-52
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
6-167 | 1.75e-51 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 178.11 E-value: 1.75e-51
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
1159-1317 | 7.19e-45 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 159.24 E-value: 7.19e-45
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NEUZ | smart00588 | domain in neuralized proteins; |
343-467 | 1.45e-44 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 157.47 E-value: 1.45e-44
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Neuralized | pfam07177 | Neuralized; This family contains a conserved region approximately 60 residues long within ... |
948-1113 | 1.61e-40 | ||||
Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region. Pssm-ID: 462112 [Multi-domain] Cd Length: 149 Bit Score: 146.91 E-value: 1.61e-40
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NEUZ | smart00588 | domain in neuralized proteins; |
549-672 | 5.49e-40 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 144.38 E-value: 5.49e-40
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NEUZ | smart00588 | domain in neuralized proteins; |
750-872 | 1.43e-31 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 120.11 E-value: 1.43e-31
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NEUZ | smart00588 | domain in neuralized proteins; |
6-124 | 5.46e-31 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 118.57 E-value: 5.46e-31
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NEUZ | smart00588 | domain in neuralized proteins; |
946-1070 | 8.01e-17 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 78.12 E-value: 8.01e-17
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NEUZ | smart00588 | domain in neuralized proteins; |
1163-1272 | 8.63e-11 | ||||
domain in neuralized proteins; Pssm-ID: 128856 Cd Length: 123 Bit Score: 60.79 E-value: 8.63e-11
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SPRY | cd11709 | SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ... |
48-165 | 4.17e-06 | ||||
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome. Pssm-ID: 293931 Cd Length: 118 Bit Score: 47.43 E-value: 4.17e-06
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SPRY | cd11709 | SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ... |
596-709 | 2.57e-05 | ||||
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome. Pssm-ID: 293931 Cd Length: 118 Bit Score: 45.11 E-value: 2.57e-05
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SPRY | cd11709 | SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ... |
390-508 | 5.21e-04 | ||||
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome. Pssm-ID: 293931 Cd Length: 118 Bit Score: 41.26 E-value: 5.21e-04
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SPRY_SOCS_Fbox | cd12875 | SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ... |
837-913 | 2.83e-03 | ||||
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis. Pssm-ID: 293935 Cd Length: 169 Bit Score: 40.52 E-value: 2.83e-03
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