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Conserved domains on  [gi|1207113293|ref|XP_021335986|]
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neuralized-like protein 4 isoform X2 [Danio rerio]

Protein Classification

SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)

SPRY_NHR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 553-713 2.18e-85

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 275.54  E-value: 2.18e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  553 FHPNCGQKAAIISDGRTALRPHatDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 632
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  633 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRKEDGSLHFFVNGVPQGPAAWNVPPNVYAVVDLYGQAAQAT 712
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   .
gi 1207113293  713 I 713
Cdd:cd12887    160 I 160
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 752-914 4.83e-84

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 271.69  E-value: 4.83e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  752 RFHQLHGTNAVITNGGRTALRqnCRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELEFPNTMTD 831
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  832 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDSLTTASRIGMMRTATGDLHYFINGLDQGVACTGLPSEVYAVVDLYGQCVQV 911
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  912 SIT 914
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 4-166 1.68e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.98  E-value: 1.68e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293    4 ELHPRSGKLIGLSNSNRTAQRnqPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLEFPSSATG 83
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   84 LKGGSWIVSGCSVLKDGRSVLEEYGRDLDQLGEGDRVGIQRNGKGELHLWVNGQDCGAAASGLPSRLWAVVDLYGKCTQV 163
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  164 TVV 166
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 347-509 2.65e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.21  E-value: 2.65e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  347 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNLDYPATMTNL 426
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  427 RSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLMRKASGALHFYINGIDQGVAANQTPGVVYGVVDLYGMAVKV 506
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  507 TIV 509
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1158-1317 9.61e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.89  E-value: 9.61e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1158 TFLENHGKNIQLSNQNLTAARV-SSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPSTACCLK 1236
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1237 RSVWLLQRDSVFHNSLKICENYGPNLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQDIPSPCYALIDLYGQCEQVTI 1316
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1207113293 1317 V 1317
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 946-1112 4.09e-65

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 217.76  E-value: 4.09e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  946 RLHSKHGKNVVLLGDGCQALRV-GGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDLPscplsgLSP 1024
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD------LPP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1025 SLTQLRTKvTWVLAGSEVRRNGVLQRQNYGCSLDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKNVYAVLDLYG 1104
Cdd:cd12887     75 SATDLKSG-TWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYG 153


                   ....*...
gi 1207113293 1105 KVTAVSIV 1112
Cdd:cd12887    154 QCEQVSIV 161
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 553-713 2.18e-85

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 275.54  E-value: 2.18e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  553 FHPNCGQKAAIISDGRTALRPHatDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 632
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  633 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRKEDGSLHFFVNGVPQGPAAWNVPPNVYAVVDLYGQAAQAT 712
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   .
gi 1207113293  713 I 713
Cdd:cd12887    160 I 160
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 752-914 4.83e-84

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 271.69  E-value: 4.83e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  752 RFHQLHGTNAVITNGGRTALRqnCRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELEFPNTMTD 831
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  832 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDSLTTASRIGMMRTATGDLHYFINGLDQGVACTGLPSEVYAVVDLYGQCVQV 911
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  912 SIT 914
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 4-166 1.68e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.98  E-value: 1.68e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293    4 ELHPRSGKLIGLSNSNRTAQRnqPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLEFPSSATG 83
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   84 LKGGSWIVSGCSVLKDGRSVLEEYGRDLDQLGEGDRVGIQRNGKGELHLWVNGQDCGAAASGLPSRLWAVVDLYGKCTQV 163
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  164 TVV 166
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 347-509 2.65e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.21  E-value: 2.65e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  347 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNLDYPATMTNL 426
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  427 RSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLMRKASGALHFYINGIDQGVAANQTPGVVYGVVDLYGMAVKV 506
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  507 TIV 509
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1158-1317 9.61e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.89  E-value: 9.61e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1158 TFLENHGKNIQLSNQNLTAARV-SSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPSTACCLK 1236
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1237 RSVWLLQRDSVFHNSLKICENYGPNLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQDIPSPCYALIDLYGQCEQVTI 1316
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1207113293 1317 V 1317
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 946-1112 4.09e-65

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 217.76  E-value: 4.09e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  946 RLHSKHGKNVVLLGDGCQALRV-GGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDLPscplsgLSP 1024
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD------LPP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1025 SLTQLRTKvTWVLAGSEVRRNGVLQRQNYGCSLDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKNVYAVLDLYG 1104
Cdd:cd12887     75 SATDLKSG-TWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYG 153


                   ....*...
gi 1207113293 1105 KVTAVSIV 1112
Cdd:cd12887    154 QCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 347-509 1.01e-56

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 193.13  E-value: 1.01e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  347 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNL---DYPATM 423
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  424 TNLRSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLMRKASGALHFYINGIDQGVAANQTP--GVVYGVVDLYG 501
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYG 140


                   ....*...
gi 1207113293  502 MAVKVTIV 509
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 553-715 4.10e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 4.10e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  553 FHPNCGQKAAIISDGRTALRphaTDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 629
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  630 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRKEDGSLHFFVNGVPQGPAAWNVPPN--VYAVVDLYGQ 707
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1207113293  708 AAQATIMD 715
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 753-915 3.72e-52

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 180.04  E-value: 3.72e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  753 FHQLHGTNAVITNGGRTALRqncRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELE---FPNTM 829
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  830 TDIDYDTWMLSgtaimQDGNTMRNNygcdldslttaSRIGMMRTATGDLHYFINGLDQGVACTGLP--SEVYAVVDLYGQ 907
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSYLQEG-----------DRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQ 141


                   ....*...
gi 1207113293  908 CVQVSITS 915
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 6-167 1.75e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 178.11  E-value: 1.75e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293    6 HPRSGKLIGLSNSNRTAQRnqpVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLE---FPSSAT 82
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   83 GLKGGSWIVSgcsvlkdgrsvleeygRDLDQLGEGDRVGIQRNGKGELHLWVNGQDCGAAASGLP--SRLWAVVDLYGKC 160
Cdd:pfam07177   79 DLRPGYWVVA----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*..
gi 1207113293  161 TQVTVVS 167
Cdd:pfam07177  143 TQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1159-1317 7.19e-45

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 159.24  E-value: 7.19e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1159 FLENHGKNIQLSNQNLTAARVSSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLN---FPSTACCL 1235
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1236 KRSVWLLQRDsvfhnslkicenygpnLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQDIP--SPCYALIDLYGQCEQ 1313
Cdd:pfam07177   81 RPGYWVVALS----------------GSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....
gi 1207113293 1314 VTIV 1317
Cdd:pfam07177  145 VSIL 148
NEUZ smart00588
domain in neuralized proteins;
343-467 1.45e-44

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 157.47  E-value: 1.45e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   343 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNLDYPAT 422
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1207113293   423 MTNLRSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLMR 467
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 948-1113 1.61e-40

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 146.91  E-value: 1.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  948 HSKHGKNVVLLGDGCQALRVGGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDLPSCPLsglsPSLT 1027
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKAL----PDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1028 QLRTKVTWVLAGSEvrrngvlqrqnygcslDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKN--VYAVLDLYGK 1105
Cdd:pfam07177   78 TDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1207113293 1106 VTAVSIVS 1113
Cdd:pfam07177  142 TTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
549-672 5.49e-40

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 144.38  E-value: 5.49e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   549 DRLLFHPNCGQKAAIISDGRTALRPHatDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPST 628
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1207113293   629 MTNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 672
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
750-872 1.43e-31

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 120.11  E-value: 1.43e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   750 DLRFHQLHGTNAVITNGGRTALRQncRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELEFPNTM 829
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1207113293   830 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDSLTTASRIGMMR 872
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
6-124 5.46e-31

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 118.57  E-value: 5.46e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293     6 HPRSGKLIGLSNSNRTAQRnqPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLEFPSSATGLK 85
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARR--SASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1207113293    86 GGSWIVSGCSVLKDGRSVLEEYG-RDLDQLGEGDRVGIQR 124
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
946-1070 8.01e-17

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 78.12  E-value: 8.01e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   946 RLHSKHGKNVVLLGDGCQALR-VGGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDL--PSCPlSGL 1022
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrpASLP-TNA 82

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1207113293  1023 SPSLtqlrtkvtWVLAGSEVRRNGVLQRQNYGC-SLDRLTVGNRVGVKR 1070
Cdd:smart00588   83 CPDL--------VDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1163-1272 8.63e-11

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 60.79  E-value: 8.63e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  1163 HGKNIQLSNQNLTAAR-VSSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPSTACCLKRSVWL 1241
Cdd:smart00588    9 HGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNACPDLVD 88

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207113293  1242 LQRDSVFHNSLKICENYGP-NLDTCPEGTVLG 1272
Cdd:smart00588   89 MSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 553-713 2.18e-85

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 275.54  E-value: 2.18e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  553 FHPNCGQKAAIISDGRTALRPHatDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 632
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  633 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRKEDGSLHFFVNGVPQGPAAWNVPPNVYAVVDLYGQAAQAT 712
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   .
gi 1207113293  713 I 713
Cdd:cd12887    160 I 160
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 752-914 4.83e-84

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 271.69  E-value: 4.83e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  752 RFHQLHGTNAVITNGGRTALRqnCRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELEFPNTMTD 831
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  832 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDSLTTASRIGMMRTATGDLHYFINGLDQGVACTGLPSEVYAVVDLYGQCVQV 911
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  912 SIT 914
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 4-166 1.68e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.98  E-value: 1.68e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293    4 ELHPRSGKLIGLSNSNRTAQRnqPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLEFPSSATG 83
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   84 LKGGSWIVSGCSVLKDGRSVLEEYGRDLDQLGEGDRVGIQRNGKGELHLWVNGQDCGAAASGLPSRLWAVVDLYGKCTQV 163
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  164 TVV 166
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 347-509 2.65e-79

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 258.21  E-value: 2.65e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  347 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNLDYPATMTNL 426
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  427 RSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLMRKASGALHFYINGIDQGVAANQTPGVVYGVVDLYGMAVKV 506
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1207113293  507 TIV 509
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1158-1317 9.61e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.89  E-value: 9.61e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1158 TFLENHGKNIQLSNQNLTAARV-SSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPSTACCLK 1236
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1237 RSVWLLQRDSVFHNSLKICENYGPNLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQDIPSPCYALIDLYGQCEQVTI 1316
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1207113293 1317 V 1317
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 946-1112 4.09e-65

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 217.76  E-value: 4.09e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  946 RLHSKHGKNVVLLGDGCQALRV-GGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDLPscplsgLSP 1024
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD------LPP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1025 SLTQLRTKvTWVLAGSEVRRNGVLQRQNYGCSLDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKNVYAVLDLYG 1104
Cdd:cd12887     75 SATDLKSG-TWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYG 153


                   ....*...
gi 1207113293 1105 KVTAVSIV 1112
Cdd:cd12887    154 QCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 347-509 1.01e-56

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 193.13  E-value: 1.01e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  347 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNL---DYPATM 423
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  424 TNLRSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLMRKASGALHFYINGIDQGVAANQTP--GVVYGVVDLYG 501
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYG 140


                   ....*...
gi 1207113293  502 MAVKVTIV 509
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 553-715 4.10e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 4.10e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  553 FHPNCGQKAAIISDGRTALRphaTDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 629
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  630 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRKEDGSLHFFVNGVPQGPAAWNVPPN--VYAVVDLYGQ 707
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1207113293  708 AAQATIMD 715
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 753-915 3.72e-52

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 180.04  E-value: 3.72e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  753 FHQLHGTNAVITNGGRTALRqncRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELE---FPNTM 829
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  830 TDIDYDTWMLSgtaimQDGNTMRNNygcdldslttaSRIGMMRTATGDLHYFINGLDQGVACTGLP--SEVYAVVDLYGQ 907
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSYLQEG-----------DRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQ 141


                   ....*...
gi 1207113293  908 CVQVSITS 915
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 6-167 1.75e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 178.11  E-value: 1.75e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293    6 HPRSGKLIGLSNSNRTAQRnqpVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLE---FPSSAT 82
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   83 GLKGGSWIVSgcsvlkdgrsvleeygRDLDQLGEGDRVGIQRNGKGELHLWVNGQDCGAAASGLP--SRLWAVVDLYGKC 160
Cdd:pfam07177   79 DLRPGYWVVA----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*..
gi 1207113293  161 TQVTVVS 167
Cdd:pfam07177  143 TQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1159-1317 7.19e-45

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 159.24  E-value: 7.19e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1159 FLENHGKNIQLSNQNLTAARVSSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLN---FPSTACCL 1235
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1236 KRSVWLLQRDsvfhnslkicenygpnLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQDIP--SPCYALIDLYGQCEQ 1313
Cdd:pfam07177   81 RPGYWVVALS----------------GSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....
gi 1207113293 1314 VTIV 1317
Cdd:pfam07177  145 VSIL 148
NEUZ smart00588
domain in neuralized proteins;
343-467 1.45e-44

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 157.47  E-value: 1.45e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   343 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRHNEMFEIRIDKLVDKWSGSIEIGVTTHNPNNLDYPAT 422
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1207113293   423 MTNLRSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLMR 467
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 948-1113 1.61e-40

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 146.91  E-value: 1.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  948 HSKHGKNVVLLGDGCQALRVGGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDLPSCPLsglsPSLT 1027
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKAL----PDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293 1028 QLRTKVTWVLAGSEvrrngvlqrqnygcslDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKN--VYAVLDLYGK 1105
Cdd:pfam07177   78 TDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1207113293 1106 VTAVSIVS 1113
Cdd:pfam07177  142 TTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
549-672 5.49e-40

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 144.38  E-value: 5.49e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   549 DRLLFHPNCGQKAAIISDGRTALRPHatDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPST 628
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1207113293   629 MTNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 672
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
750-872 1.43e-31

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 120.11  E-value: 1.43e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   750 DLRFHQLHGTNAVITNGGRTALRQncRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVTAIRPEELEFPNTM 829
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1207113293   830 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDSLTTASRIGMMR 872
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
6-124 5.46e-31

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 118.57  E-value: 5.46e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293     6 HPRSGKLIGLSNSNRTAQRnqPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIGVTALDPAGLEFPSSATGLK 85
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARR--SASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1207113293    86 GGSWIVSGCSVLKDGRSVLEEYG-RDLDQLGEGDRVGIQR 124
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
946-1070 8.01e-17

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 78.12  E-value: 8.01e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   946 RLHSKHGKNVVLLGDGCQALR-VGGYAHGIVFSAKELKTDEVFEVKINKVDERWSGSLHVGLTTLQPPDL--PSCPlSGL 1022
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrpASLP-TNA 82

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1207113293  1023 SPSLtqlrtkvtWVLAGSEVRRNGVLQRQNYGC-SLDRLTVGNRVGVKR 1070
Cdd:smart00588   83 CPDL--------VDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1163-1272 8.63e-11

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 60.79  E-value: 8.63e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  1163 HGKNIQLSNQNLTAAR-VSSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPSTACCLKRSVWL 1241
Cdd:smart00588    9 HGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNACPDLVD 88

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207113293  1242 LQRDSVFHNSLKICENYGP-NLDTCPEGTVLG 1272
Cdd:smart00588   89 MSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 48-165 4.17e-06

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 47.43  E-value: 4.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293   48 FTVRIDKkvnSWSGSIEIGVTalDPAGLEFPSSATGLKGGSWIVSGCSVLKDGRSVLEEYGRdldQLGEGDRVGIQRN-G 126
Cdd:cd11709      5 WEVRVDS---GNGGLIQVGWA--TKSFSLDGEGGVGDDEESWGYDGSRLRKGHGGSSGPGGR---PWKSGDVVGCLLDlD 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1207113293  127 KGELHLWVNGQDCGAAASGLPS---RLWAVVDLYGKCtQVTV 165
Cdd:cd11709     77 EGTLSFSLNGKDLGVAFTNLFLkggGLYPAVSLGSGQ-GVTI 117
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 596-709 2.57e-05

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 45.11  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  596 FQVRIDKMVDkwaGSIEIGVTTHNPAYLQLPSTMTNLRSgtWMMTGNGVmHNGTTILDEYGhnLDRLKAGDTVGV-VRKE 674
Cdd:cd11709      5 WEVRVDSGNG---GLIQVGWATKSFSLDGEGGVGDDEES--WGYDGSRL-RKGHGGSSGPG--GRPWKSGDVVGClLDLD 76

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1207113293  675 DGSLHFFVNGVPQGPAAWNV---PPNVYAVVDLYGQAA 709
Cdd:cd11709     77 EGTLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQG 114
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 390-508 5.21e-04

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 41.26  E-value: 5.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  390 FEIRIDKlvdKWSGSIEIGVTTHNPNNLDYPATMTNLRSgtimmsgCGILTNGKGTR-REYCEFSLDELQEGDHIG-LMR 467
Cdd:cd11709      5 WEVRVDS---GNGGLIQVGWATKSFSLDGEGGVGDDEES-------WGYDGSRLRKGhGGSSGPGGRPWKSGDVVGcLLD 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1207113293  468 KASGALHFYINGIDQGVAA---NQTPGVVYGVVDLYGMAvKVTI 508
Cdd:cd11709     75 LDEGTLSFSLNGKDLGVAFtnlFLKGGGLYPAVSLGSGQ-GVTI 117
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 837-913 2.83e-03

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 40.52  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207113293  837 WMLSGTAIMQDGNTMRNNYGCDLDSLTTASRIGMMRTA-TGDLHYFINGLDQGVACTGLPSE-VY-AVVDLYGQCvQVSI 913
Cdd:cd12875     88 WDLGDNKLYHNGKKVIGSYPAKSENYQVPDRILVILDMeDGTLAFEANGEYLGVAFRGLPGKlLYpAVSAVYGNC-EIRL 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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