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Conserved domains on  [gi|1207181426|ref|XP_021333540|]
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leucine-rich repeat-containing G-protein coupled receptor 4 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 527-811 1.62e-146

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320483  Cd Length: 274  Bit Score: 436.22  E-value: 1.62e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSsLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15361     1 WMIRLTVWFIFLVALFFNLLVILTTFASCTS-LPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMGKAGALRSRGerrerrrrFAIAALLLGLVSVAAACLSLYHGSA-MG 685
Cdd:cd15361    80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQ--------FQIAALLAFLVATAAGCLPLFHGGEySA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15361   152 SPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1207181426 766 PLLAGTSnavGGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15361   232 PLITAIS---ISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-452 4.08e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.99  E-value: 4.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  85 YLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLD 164
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 165 DNSLTEVPISPLQHQSNLQALTLALNrithipdNAFANLSSLVVLHLHNNRIQEIGKNcFNGLDNLETLDLNFNNLKIFP 244
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 245 EAIQMLPKLKELGFHSNNIASIPEgAFCRNSLLRTIHLFDNPLSfvgttafqnlsdlhslmlrgasmmqDFP-SLTGTIN 323
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT-------------------------DLPePLGNLTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 324 LESLTLTGTKIRSIPADLcEDLTVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDrgTFQGMTSLRVLDLSRNQ 403
Cdd:COG4886   207 LEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQ 283

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1207181426 404 IKFIHRDAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLTGNMELRN 452
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
 
Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 527-811 1.62e-146

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 436.22  E-value: 1.62e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSsLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15361     1 WMIRLTVWFIFLVALFFNLLVILTTFASCTS-LPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMGKAGALRSRGerrerrrrFAIAALLLGLVSVAAACLSLYHGSA-MG 685
Cdd:cd15361    80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQ--------FQIAALLAFLVATAAGCLPLFHGGEySA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15361   152 SPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1207181426 766 PLLAGTSnavGGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15361   232 PLITAIS---ISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-452 4.08e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.99  E-value: 4.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  85 YLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLD 164
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 165 DNSLTEVPISPLQHQSNLQALTLALNrithipdNAFANLSSLVVLHLHNNRIQEIGKNcFNGLDNLETLDLNFNNLKIFP 244
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 245 EAIQMLPKLKELGFHSNNIASIPEgAFCRNSLLRTIHLFDNPLSfvgttafqnlsdlhslmlrgasmmqDFP-SLTGTIN 323
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT-------------------------DLPePLGNLTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 324 LESLTLTGTKIRSIPADLcEDLTVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDrgTFQGMTSLRVLDLSRNQ 403
Cdd:COG4886   207 LEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQ 283

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1207181426 404 IKFIHRDAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLTGNMELRN 452
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-447 3.46e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.47  E-value: 3.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  53 SVPTGLSAFTYYLDISMNNIT-ELPANV--FRNLPYLEelrLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALK 129
Cdd:PLN00113  133 SIPRGSIPNLETLDLSNNMLSgEIPNDIgsFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELG 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 130 NLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSLT-EVPISpLQHQSNLQALTLALNRIT-HIPDNAFaNLSSLV 207
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLI 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 208 VLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNL--KIfPEAIQMLPKLKELGFHSNNIAS-------------------- 265
Cdd:PLN00113  288 SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFtgKI-PVALTSLPRLQVLQLWSNKFSGeipknlgkhnnltvldlstn 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 266 -----IPEGaFCRNSLLRTIHLFDNPLSFVGTTAFQNLSDLHSLMLRGASMMQDFPS------LTGTINLESLTLTGtKI 334
Cdd:PLN00113  367 nltgeIPEG-LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSeftklpLVYFLDISNNNLQG-RI 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 335 RSIPAdlceDLTVLRTVDLSYNDIE-DLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFL 413
Cdd:PLN00113  445 NSRKW----DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELS 520

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1207181426 414 SLSALTNLDLSLNSLASVPTAGLS---ALNQLKLTGN 447
Cdd:PLN00113  521 SCKKLVSLDLSHNQLSGQIPASFSempVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-267 1.32e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  89 LRLAGNDLAFIhpEALSGLHQLKVLMLQNNQLKTVPSaaLKNLNALQSLRLDANHITSVpeDSFEGLQQLRHLWLDDNSL 168
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 169 TEVpiSPLQHQSNLQALTLALNRIThiPDNAF-------ANLS-SLVVLHLHNNRIQEIgkNCFNGLDNLETLDLNFNNL 240
Cdd:cd21340    81 SVV--EGLENLTNLEELHIENQRLP--PGEKLtfdprslAALSnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207181426 241 KIFPEAIQML---PKLKELGFHSNNIASIP 267
Cdd:cd21340   155 SDLEELLDLLsswPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
369-428 1.42e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.42e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 369 RLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSL 428
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 544-800 3.89e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 544 NCLVLAATFSPRtSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSfaeygvwWETG-AGCQVVGFLAVFSSEWAV 622
Cdd:pfam00001   2 NLLVILVILRNK-KLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 623 LLLALAAVERCLA-VRALMGKAgalrsrgerrerRRRFAIAALLLGLVSVAAACLSL---YHGSAMGSP-----LCLP-F 692
Cdd:pfam00001  74 LLLTAISIDRYLAiVHPLRYKR------------RRTPRRAKVLILVIWVLALLLSLpplLFGWTLTVPegnvtVCFIdF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 693 SEGSSPGLGFTvalVLMNTLAYLLS----AVVYTRLYCRL--GRAQLADPEQAGSVRHIAW----LIFTNCIFFCPVAAF 762
Cdd:pfam00001 142 PEDLSKPVSYT---LLISVLGFLLPllviLVCYTLIIRTLrkSASKQKSSERTQRRRKALKtlavVVVVFILCWLPYHIV 218

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1207181426 763 SFAPLLAGTSNAVGGPEMAKSVTLIFFPLSACLNPVLY 800
Cdd:pfam00001 219 NLLDSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
LRR smart00370
Leucine-rich repeats, outliers;
391-412 4.59e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.59e-03
                           10        20
                   ....*....|....*....|..
gi 1207181426  391 MTSLRVLDLSRNQIKFIHRDAF 412
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 527-811 1.62e-146

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 436.22  E-value: 1.62e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSsLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15361     1 WMIRLTVWFIFLVALFFNLLVILTTFASCTS-LPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMGKAGALRSRGerrerrrrFAIAALLLGLVSVAAACLSLYHGSA-MG 685
Cdd:cd15361    80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQ--------FQIAALLAFLVATAAGCLPLFHGGEySA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15361   152 SPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1207181426 766 PLLAGTSnavGGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15361   232 PLITAIS---ISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 527-811 1.83e-89

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 286.75  E-value: 1.83e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSsLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15138     1 WMIRLTVWFIFLLALFCNLLVILTVFASCTS-LPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALM--GKAGALRSrgerrerrrrFAIAALLLGLVSVAAACLSLYHGSAM 684
Cdd:cd15138    80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMknGKSNHLKS----------FRVAALLCFLLATVAAAFPLFHRGEY 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 685 G-SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFS 763
Cdd:cd15138   150 GaSPLCLPFPTGEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLS 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1207181426 764 FAPLLAGTSNAvggPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15138   230 FASLITLISIS---PEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 527-810 3.02e-63

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 215.42  E-value: 3.02e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSpRTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFA-SPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRAL--MGKAGALRSRGERRERRRRFAIAALLLGLVSVaaaclslyhGSAM 684
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVraYGKSPSLGSVRAAALCCLALSLTAAALPLFSV---------GEYG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 685 GSPLCLPFS--EGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAF 762
Cdd:cd15362   151 ASPLCLPSPlpDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1207181426 763 SFAPLLAGTSNavgGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYD 810
Cdd:cd15362   231 TFSSLLNLFPI---SPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDD 275
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 527-810 1.13e-58

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 202.38  E-value: 1.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPrTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15363     1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRAlmgkagalRSRGERRERRRRFAIAALLLGLVSVAAACLSLYHGSAMG- 685
Cdd:cd15363    80 CQITGFLSIFASESSVFLLTLAALERGFSVKC--------STKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGa 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15363   152 SPLCLPLPFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFS 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1207181426 766 PLLAGTSNAvggPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYD 810
Cdd:cd15363   232 SLLNLTFIS---PEVIKFILLVIVPLPACLNPLLYILFNPHFKED 273
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 527-810 4.97e-42

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 155.07  E-value: 4.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSSLSPsRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd15136     1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVP-RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALM--GKAGALRSRGERRERRRRFAIAALLLGLVSVaaaclSLYHGSAM 684
Cdd:cd15136    80 CKTAGFLAVFSSELSVFTLTVITLERWYAITHAMhlNKRLSLRQAAIIMLGGWIFALIMALLPLVGV-----SSYSKTSI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 685 gsplCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSV-RHIAWLIFTNCIFFCPVAAFS 763
Cdd:cd15136   155 ----CLPFETETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNDTRIaKRMALLVFTDFLCWAPIAFFG 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207181426 764 FA-----PLLAGTSnavggpemAKSVTLIFFPLSACLNPVLYVCFSPSFRYD 810
Cdd:cd15136   231 LTaafglPLISVSN--------AKILLVFFYPLNSCANPFLYAIFTKQFRRD 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-452 4.08e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.99  E-value: 4.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  85 YLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLD 164
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 165 DNSLTEVPISPLQHQSNLQALTLALNrithipdNAFANLSSLVVLHLHNNRIQEIGKNcFNGLDNLETLDLNFNNLKIFP 244
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 245 EAIQMLPKLKELGFHSNNIASIPEgAFCRNSLLRTIHLFDNPLSfvgttafqnlsdlhslmlrgasmmqDFP-SLTGTIN 323
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT-------------------------DLPePLGNLTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 324 LESLTLTGTKIRSIPADLcEDLTVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDrgTFQGMTSLRVLDLSRNQ 403
Cdd:COG4886   207 LEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQ 283

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1207181426 404 IKFIHRDAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLTGNMELRN 452
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-452 4.59e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 4.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  51 LTSVPTGLSAFTYYLDISMNNITELPANVFRNLPYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKN 130
Cdd:COG4886    15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 131 LNALQSLRLDANhitsvpeDSFEGLQQLRHLWLDDNSLTEVPISpLQHQSNLQALTLALNRITHIPDnAFANLSSLVVLH 210
Cdd:COG4886    95 LTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 211 LHNNRIQEIGKNcFNGLDNLETLDLNFNNLKIFPEAIQMLPKLKELGFHSNNIASIPEgAFCRNSLLRTIHLFDNPLSfv 290
Cdd:COG4886   166 LSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-- 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 291 gttafqnlsdlhslmlrgasmmqDFPSLTGTINLESLTLTGTKIRSIPAdlCEDLTVLRTVDLSYNDIED-----LPSFQ 365
Cdd:COG4886   242 -----------------------DLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDlklkeLELLL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 366 GCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLT 445
Cdd:COG4886   297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376


                  ....*..
gi 1207181426 446 GNMELRN 452
Cdd:COG4886   377 ATLLTLA 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-306 1.19e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 134.68  E-value: 1.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  45 DCSGRGLTSVPTGLSAFTY--YLDISMNNITELPAnVFRNLPYLEELRLAGNDLAFIhPEALSGLHQLKVLMLQNNQLKT 122
Cdd:COG4886   119 DLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 123 VPsAALKNLNALQSLRLDANHITSVPEdSFEGLQQLRHLWLDDNSLTEVPIspLQHQSNLQALTLALNRITHIPDNAfaN 202
Cdd:COG4886   197 LP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--N 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 203 LSSLVVLHLHNNRIQEI---GKNCFNGLDNLETLDLNFNNLKIFPEAIQMLPKLKELGFHSNNIASIPEGAFCRNSLLRT 279
Cdd:COG4886   271 LTNLKTLDLSNNQLTDLklkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                         250       260
                  ....*....|....*....|....*..
gi 1207181426 280 IHLFDNPLSFVGTTAFQNLSDLHSLML 306
Cdd:COG4886   351 TLLLLLNLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-445 2.74e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 2.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  82 NLPYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQlktvpsaALKNLNALQSLRLDANHITSVPEdSFEGLQQLRHL 161
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 162 WLDDNSLTEVPiSPLQHQSNLQALTLALNRITHIPDnAFANLSSLVVLHLHNNRIQEIGKNcFNGLDNLETLDLNFNNLK 241
Cdd:COG4886   142 DLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLT 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 242 IFPEAIQMLPKLKELGFHSNNIASIPEgaFCRNSLLRTIHLFDNPLSfvgttafqnlsdlhslmlrgasmmqDFPSLTGT 321
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLT-------------------------DLPPLANL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 322 INLESLTLTGTKIRSIPADLCEDLTVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDRGTFQgmTSLRVLDLSR 401
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT--LALSLSLLAL 349

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1207181426 402 NQIKFIHRDAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLT 445
Cdd:COG4886   350 LTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 527-810 3.03e-30

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 121.19  E-value: 3.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAG 606
Cdd:cd14980     1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 607 CQVVGFLAVFSSEWAVLLLALAAVERCLA-VRALMGKAGALRSRGERRERRRRFAIAALLLGLV-SVAAACLSLYHGSam 684
Cdd:cd14980    81 CLLACFLVSLSSLMSVLMMLLITLDRYICiVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILySINQPGDNRLYGY-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 685 gSPLCLP--FSEGSSpgLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGS-----VRHIAWLIFTNCIFFC 757
Cdd:cd14980   159 -SSICMPsnVSNPYY--RGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARRSSSKrdkriAIRLALILITDLICWL 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207181426 758 PVAAFSFAPLLagTSNAVgGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYD 810
Cdd:cd14980   236 PYYIVIFSGLL--TSTEI-DIHVLQFIAILALPLNSAINPYLYTLTTPTFKRD 285
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 529-810 1.64e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 110.38  E-value: 1.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 529 IRLTVWFICLVALLFNCLVLAATFSPRTSsLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGCQ 608
Cdd:cd15964     3 LRIVVWFVNLLAILGNVFVLLILLTSHYK-LTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 609 VVGFLAVFSSEWAVLLLALAAVERCLAVRALM--GKAGALRSRGERRERRRRFAIAALLLGLVSVAaaclslyhgSAMGS 686
Cdd:cd15964    82 TAGFFTVFASELSVYTLTVITLERWYAITFAMrlDRKIRLRHASAIMLGGWVFCFLLALLPLVGVS---------SYAKV 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 687 PLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSV-RHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15964   153 SICLPMDTETPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSGDKDTKIaKRMAVLIFTDFICMAPISFYALS 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1207181426 766 PLLAGTSNAVGGpemAKSVTLIFFPLSACLNPVLYVCFSPSFRYD 810
Cdd:cd15964   233 AILNKPLITVSN---SKILLVLFYPLNSCANPFLYAIFTKAFRRD 274
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 528-811 1.73e-24

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 104.17  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 528 MIRLTVWFICLVALLFNCLVLAATFSPRTSSLSPsRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGC 607
Cdd:cd15360     2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVP-RFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 608 QVVGFLAVFSSEWAVLLLALAAVERCLAVRALM--GKAGALRSRGERRERRRRFAIAALLLGLVSVAaaclslyhgSAMG 685
Cdd:cd15360    81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMqlDRKVRLRHAAVIMVGGWIFAFTVALLPIFGIS---------SYMK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSV-RHIAWLIFTNCIFFCPVAAFSF 764
Cdd:cd15360   152 VSICLPMDIESPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKIaKRMAVLIFTDFLCMAPISFFAI 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207181426 765 A-----PLLAGTSnavggpemAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15360   232 SaslkvPLITVSK--------SKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 529-811 8.15e-24

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 102.25  E-value: 8.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 529 IRLTVWFICLVALLFNCLVLAATFSPRtSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGCQ 608
Cdd:cd15359     3 LRVLIWFINILAIAGNLIVLFVLLTSR-YKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 609 VVGFLAVFSSEWAVLLLALAAVERCLAVRALM--GKAGALRSRGERRERRRRFAIAALLLGLVSVAaaclslyhgSAMGS 686
Cdd:cd15359    82 TAGFFTVFASELSVYTLTVITLERWHTITYAMqlDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVS---------NYMKV 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 687 PLCLPFSEGSSPGLGFTVALVLMNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSV-RHIAWLIFTNCIFFCPVAAFSFA 765
Cdd:cd15359   153 SICLPMDIETLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIaKRMAILIFTDFTCMAPISFFAIS 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1207181426 766 -----PLLAGTSnavggpemAKSVTLIFFPLSACLNPVLYVCFSPSFRYDW 811
Cdd:cd15359   233 aafkvPLITVTN--------SKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-447 3.46e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.47  E-value: 3.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  53 SVPTGLSAFTYYLDISMNNIT-ELPANV--FRNLPYLEelrLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALK 129
Cdd:PLN00113  133 SIPRGSIPNLETLDLSNNMLSgEIPNDIgsFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELG 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 130 NLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSLT-EVPISpLQHQSNLQALTLALNRIT-HIPDNAFaNLSSLV 207
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSS-LGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLI 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 208 VLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNL--KIfPEAIQMLPKLKELGFHSNNIAS-------------------- 265
Cdd:PLN00113  288 SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFtgKI-PVALTSLPRLQVLQLWSNKFSGeipknlgkhnnltvldlstn 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 266 -----IPEGaFCRNSLLRTIHLFDNPLSFVGTTAFQNLSDLHSLMLRGASMMQDFPS------LTGTINLESLTLTGtKI 334
Cdd:PLN00113  367 nltgeIPEG-LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSeftklpLVYFLDISNNNLQG-RI 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 335 RSIPAdlceDLTVLRTVDLSYNDIE-DLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFL 413
Cdd:PLN00113  445 NSRKW----DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELS 520

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1207181426 414 SLSALTNLDLSLNSLASVPTAGLS---ALNQLKLTGN 447
Cdd:PLN00113  521 SCKKLVSLDLSHNQLSGQIPASFSempVLSQLDLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-448 1.21e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 94.91  E-value: 1.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  65 LDISMNNIT-ELPANVFRnLPYLEELRLAGNDLAFIHPEALSGL-HQLKVLMLQNNQLK-TVPSAALKNlnaLQSLRLDA 141
Cdd:PLN00113   74 IDLSGKNISgKISSAIFR-LPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGSIPN---LETLDLSN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 142 NHIT-SVPED--SFeglQQLRHLWLDDNSLT-EVPISpLQHQSNLQALTLALNRITHIPDNAFANLSSLVVLHL-HNNRI 216
Cdd:PLN00113  150 NMLSgEIPNDigSF---SSLKVLDLGGNVLVgKIPNS-LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLS 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 217 QEIGKNcFNGLDNLETLDLNFNNLK-IFPEAIQMLPKLKELGFHSNNIA-SIPEGAF----------CRNSL-------- 276
Cdd:PLN00113  226 GEIPYE-IGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFslqklisldlSDNSLsgeipelv 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 277 -----LRTIHLFDNPLSFVGTTAFQNLSDLHSLMLRGASMMQDFPSLTGTIN------LESLTLTGtkirSIPADLCEDL 345
Cdd:PLN00113  305 iqlqnLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNnltvldLSTNNLTG----EIPEGLCSSG 380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 346 TVLRTVDLSyNDIEDL--PSFQGCVRLQDINLQHNQIK----------------QIDRGTFQG--------MTSLRVLDL 399
Cdd:PLN00113  381 NLFKLILFS-NSLEGEipKSLGACRSLRRVRLQDNSFSgelpseftklplvyflDISNNNLQGrinsrkwdMPSLQMLSL 459

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207181426 400 SRNQIKFIHRDAFLSlSALTNLDLSLNSLA-SVPTA--GLSALNQLKLTGNM 448
Cdd:PLN00113  460 ARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKlgSLSELMQLKLSENK 510
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-267 1.32e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  89 LRLAGNDLAFIhpEALSGLHQLKVLMLQNNQLKTVPSaaLKNLNALQSLRLDANHITSVpeDSFEGLQQLRHLWLDDNSL 168
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 169 TEVpiSPLQHQSNLQALTLALNRIThiPDNAF-------ANLS-SLVVLHLHNNRIQEIgkNCFNGLDNLETLDLNFNNL 240
Cdd:cd21340    81 SVV--EGLENLTNLEELHIENQRLP--PGEKLtfdprslAALSnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207181426 241 KIFPEAIQML---PKLKELGFHSNNIASIP 267
Cdd:cd21340   155 SDLEELLDLLsswPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 155-422 2.10e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 155 LQQLRHLWLDDNSLTEvpISPLQHQSNLQALTLALNRITHIPDnaFANLSSLVVLHLHNNRIQEIGKncFNGLDNLETLD 234
Cdd:cd21340     1 LKRITHLYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 235 LNFNNLKIFpEAIQMLPKLKELgfhsnniasipegafcrnsllrtiHLfDNplsfvgttafQNLSdlhslmlRGASMMQD 314
Cdd:cd21340    75 LGGNRISVV-EGLENLTNLEEL------------------------HI-EN----------QRLP-------PGEKLTFD 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 315 fpsltgtinlesltltgtkIRSIPAdLCEDLTVLrtvDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDR--GTFQGMT 392
Cdd:cd21340   112 -------------------PRSLAA-LSNSLRVL---NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1207181426 393 SLRVLDLSRNQIKFIH--RDAFLSLSA-LTNLD 422
Cdd:cd21340   169 SLRELDLTGNPVCKKPkyRDKIILASKsLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
369-428 1.42e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.42e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 369 RLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSL 428
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
180-240 1.60e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.60e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207181426 180 SNLQALTLALNRITHIPDNAFANLSSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNL 240
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 529-808 2.71e-13

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 71.46  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 529 IRLTVWFICLVALLFNCLVLAATFSPRTSSLSPSrFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGCQ 608
Cdd:cd15137     3 LRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHS-FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWLCT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 609 VVGFLAVFSSEWAVLLLALAAVERCLAVRALMGKAGalrsrgerrerrRRFAIAALLLGLVSVAAACLSL-------YHG 681
Cdd:cd15137    82 FAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRR------------LGLRRAIIVLACIWLIGLLLAVlpllpwdYFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 682 SAMG-SPLCLPF--SEGSSPGLGFTVALVL-MNTLAYLLSAVVYTRLYCRLGR-AQLADPEQAGS----VRHIAWLIFTN 752
Cdd:cd15137   150 NFYGrSGVCLPLhiTDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtRKAAASRKSKRdmavAKRFFLIVLTD 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207181426 753 CIFFCPVAAFSFAPLlagtSNAVGGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFR 808
Cdd:cd15137   230 FLCWIPIIVIGILAL----SGVPIPGEVYAWVAVFVLPINSALNPILYTLSTPKFR 281
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-268 7.67e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 7.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  50 GLTSVPTGLSAFTYYLDISMNNITELPANVFRNlpyLEELRLAGNDLAFIhPEALSglHQLKVLMLQNNQLKTVPSaalK 129
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSI-PATLP--DTIQEMELSINRITELPE---R 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 130 NLNALQSLRLDANHITSVPEDSFEGLQQLRhlwLDDNSLTEVP------ISPLQHQSN-LQAL--TLALN-RITHIPDNA 199
Cdd:PRK15370  260 LPSALQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTLPahlpsgITHLNVQSNsLTALpeTLPPGlKTLEAGENA 336

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207181426 200 FANL-----SSLVVLHLHNNRIQEIGKNCfngLDNLETLDLNFNNLKIFPEAiqmLP-KLKELGFHSNNIASIPE 268
Cdd:PRK15370  337 LTSLpaslpPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPEN---LPaALQIMQASRNNLVRLPE 405
LRR_8 pfam13855
Leucine rich repeat;
348-404 1.97e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207181426 348 LRTVDLSYNDIEDLP--SFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQI 404
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-247 2.58e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  51 LTSVPTGLSAFTYYLDISMNNITELPanvfRNLPY-LEELRLAGNDLAFIhPEALSglHQLKVLMLQNNQLKTVPsAALK 129
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLP-AHLP 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 130 nlNALQSLRLDANHITSVPEDSFEGLQQLRhlwLDDNSLTEVPIS-PlqhqSNLQALTLALNRITHIPDNAFANLSSLVV 208
Cdd:PRK15370  304 --SGITHLNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASlP----PELQVLDVSKNQITVLPETLPPTITTLDV 374

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1207181426 209 LHlhnNRIQEIGKNCFNGLDNLETldlNFNNLKIFPEAI 247
Cdd:PRK15370  375 SR---NALTNLPENLPAALQIMQA---SRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
84-144 7.38e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 7.38e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207181426  84 PYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHI 144
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
38-288 1.24e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.57  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  38 CDEDGGA--DCSGRGLTSVPTGLSAFTYYLDISMNNITELPA------------NVFRNLPYLE----ELRLAGNDLAFI 99
Cdd:PRK15387  198 CLNNGNAvlNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAlppelrtlevsgNQLTSLPVLPpgllELSIFSNPLTHL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 100 hPEALSGLHQLKVLmlqNNQLKTVPSAAlknlNALQSLRLDANHITSVPEDSFEglqqLRHLWLDDNSLTEVPISPlqhq 179
Cdd:PRK15387  278 -PALPSGLCKLWIF---GNQLTSLPVLP----PGLQELSVSDNQLASLPALPSE----LCKLWAYNNQLTSLPTLP---- 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 180 SNLQALTLALNRITHIPDNAfanlSSLVVLHLHNNRIQEIgKNCFNGLDNLETLDLNFNNLKIFPEAIQ----------- 248
Cdd:PRK15387  342 SGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLTSL-PALPSGLKELIVSGNRLTSLPVLPSELKelmvsgnrlts 416

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1207181426 249 --MLPK-LKELGFHSNNIASIPEgAFCRNSLLRTIHLFDNPLS 288
Cdd:PRK15387  417 lpMLPSgLLSLSVYRNQLTRLPE-SLIHLSSETTVNLEGNPLS 458
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 256-447 1.31e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 256 LGFHSNNIASIPEGAFCRNslLRTIHLFDNPLSfvgttafqNLSDLHSLmlrgasmmqdfpsltgtINLESLTLTGTKIR 335
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKN--LKVLYLYDNKIT--------KIENLEFL-----------------TNLTHLYLQNNQIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 336 SI-PADLCEDLTVLrtvDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMT------SLRVLDLSRNQIKFIh 408
Cdd:cd21340    60 KIeNLENLVNLKKL---YLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSL- 135

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207181426 409 rDAFLSLSALTNLDLSLNSLASV-----PTAGLSALNQLKLTGN 447
Cdd:cd21340   136 -EPLAPLRNLEQLDASNNQISDLeelldLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
204-263 2.16e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207181426 204 SSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNLK-IFPEAIQMLPKLKELGFHSNNI 263
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
156-216 5.86e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 5.86e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207181426 156 QQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRITHIPDNAFANLSSLVVLHLHNNRI 216
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 121-301 1.29e-09

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 57.17  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 121 KTVPSAALKNLNaLQSLRLDaNHITSVPEDSFEGLQQLRHLWLDDNsltevpisplqhqsnlqaltlalnrITHIPDNAF 200
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-------------------------LTSIGSYAF 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 201 ANlSSLVVLHLHNNrIQEIGKNCFNGLDNLETLDLnfnnlkifpeaiqmlpklkelgfhSNNIASIPEGAFCrNSLLRTI 280
Cdd:pfam13306  54 YN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITL------------------------PSNLTSIGSYAFS-NCSLKSI 106

                         170       180
                  ....*....|....*....|.
gi 1207181426 281 HLFDNpLSFVGTTAFQNLSDL 301
Cdd:pfam13306 107 TIPSS-VTTIGSYAFSNCSNL 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-251 1.52e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  45 DCSGRGLTSVPTGLSAFT--YYLDISMNNITELPAnvFRNLPYLEELRLAGNDLAFIHPEAlsGLHQLKVLMLQNNQLKT 122
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 123 VPSAALKNLNALQSLRLDANHITSVPEdsFEGLQQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRITHIPDNAFAN 202
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLEL--LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1207181426 203 LSSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNLKIFPEAIQMLP 251
Cdd:COG4886   365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR_8 pfam13855
Leucine rich repeat;
109-168 5.90e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.90e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 109 QLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSL 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
63-120 1.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 1.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207181426  63 YYLDISMNNITELPANVFRNLPYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQL 120
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 72-418 1.28e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  72 ITELPANVFRNLPYLEELRLAGNDLAFIHPEAL-SGLH---QLKVLMLQNNQLKTVPSA------ALKNLNALQSLRLDA 141
Cdd:cd00116    11 KTERATELLPKLLCLQVLRLEGNTLGEEAAKALaSALRpqpSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 142 NHITSVPEDSFEGLQQ---LRHLWLDDNSL--TEVPI---SPLQHQSNLQALTLALNRITHIPDNAFANL----SSLVVL 209
Cdd:cd00116    91 NALGPDGCGVLESLLRsssLQELKLNNNGLgdRGLRLlakGLKDLPPALEKLVLGRNRLEGASCEALAKAlranRDLKEL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 210 HLHNNRIQEIG----KNCFNGLDNLETLDLNfnNLKIFPEAIQMLpklkelgfhsnniasipEGAFCRNSLLRTIHLFDN 285
Cdd:cd00116   171 NLANNGIGDAGiralAEGLKANCNLEVLDLN--NNGLTDEGASAL-----------------AETLASLKSLEVLNLGDN 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 286 PLSFVGttafqnLSDLHSLMLRGAsmmqdfpsltgtinlesltltgtkirsipadlcedlTVLRTVDLSYNDIEDLPSFQ 365
Cdd:cd00116   232 NLTDAG------AAALASALLSPN------------------------------------ISLLTLSLSCNDITDDGAKD 269

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207181426 366 GCVRLQDinlqhnqikqidrgtfqgMTSLRVLDLSRNqiKFIHRDAFLSLSAL 418
Cdd:cd00116   270 LAEVLAE------------------KESLLELDLRGN--KFGEEGAQLLAESL 302
LRR_8 pfam13855
Leucine rich repeat;
392-447 3.37e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 3.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207181426 392 TSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSLASVPT---AGLSALNQLKLTGN 447
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGN 59
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-439 4.80e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.72  E-value: 4.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 110 LKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSL----TEVPISPLQHQ----SN 181
Cdd:COG5238    63 LRFEGQGDPGLNPVALEKAAEAFPTQLLVVDWEGAEEVSPVALAETATAVATPPPDLRRimakTLEDSLILYLAlprrIN 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 182 LQALTLALNRIT-HIPDNAFANLSSLVVLHLHNnriqeigkncFNGLDNLETLDLNFNNL-----KIFPEAIQMLPKLKE 255
Cdd:COG5238   143 LIQVLKDPLGGNaVHLLGLAARLGLLAAISMAK----------ALQNNSVETVYLGCNQIgdegiEELAEALTQNTTVTT 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 256 LGFHSNNIAsiPEGA------FCRNSLLRTIHLFDNPLSFVGTTAF----QNLSDLHSLMLRG-----------ASMMQD 314
Cdd:COG5238   213 LWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQIGDEGVIALaealKNNTTVETLYLSGnqigaegaialAKALQG 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 315 FPSLTgTINLESLTLTGTKIRSIpADLCEDLTVLRTVDLSYNDIEDlpsfQGCVRL----------QDINLQHNQIKqiD 384
Cdd:COG5238   291 NTTLT-SLDLSVNRIGDEGAIAL-AEGLQGNKTLHTLNLAYNGIGA----QGAIALakalqenttlHSLDLSDNQIG--D 362

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207181426 385 RGT------FQGMTSLRVLDLSRNQikfIHRDAFLSLSA------LTNLDLSLNSLASVPTAGLSAL 439
Cdd:COG5238   363 EGAialakyLEGNTTLRELNLGKNN---IGKQGAEALIDalqtnrLHTLILDGNLIGAEAQQRLEQL 426
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 227-452 6.43e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 6.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 227 LDNLETLDLNFNNL-----KIFPEAIQMLPKLKELGFHSNNIASIPEG------AFCRNSLLRTIHLFDNPLSFVGTTAF 295
Cdd:cd00116    22 LLCLQVLRLEGNTLgeeaaKALASALRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 296 QNLsdLHSLMLRGASMMQdfpsltgtiNLESLTLTGTKIRSIPaDLCEDLTVLrtvDLSYNDIEDLPS------FQGCVR 369
Cdd:cd00116   102 ESL--LRSSSLQELKLNN---------NGLGDRGLRLLAKGLK-DLPPALEKL---VLGRNRLEGASCealakaLRANRD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 370 LQDINLQHNQIKqiDRGT---FQGM---TSLRVLDLSRNQI-----KFIhRDAFLSLSALTNLDLSLNSLASvptAGLSA 438
Cdd:cd00116   167 LKELNLANNGIG--DAGIralAEGLkanCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLTD---AGAAA 240

                         250
                  ....*....|....
gi 1207181426 439 LNQLKLTGNMELRN 452
Cdd:cd00116   241 LASALLSPNISLLT 254
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-198 9.15e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 9.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  45 DCSGRGLTSVPTGLSAFTYYLDISMNNITELPAnvfrNLPY-LEELRLAGNDLAFIhPEALSglHQLKVLMLQNNQLKTV 123
Cdd:PRK15370  268 DLFHNKISCLPENLPEELRYLSVYDNSIRTLPA----HLPSgITHLNVQSNSLTAL-PETLP--PGLKTLEAGENALTSL 340

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207181426 124 PSAALKnlnALQSLRLDANHITSVPEDSFEGLQQlrhLWLDDNSLTEVPIS-PlqhqSNLQALTLALNRITHIPDN 198
Cdd:PRK15370  341 PASLPP---ELQVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPENlP----AALQIMQASRNNLVRLPES 406
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 535-804 2.19e-07

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 535 FICLVALLFNCLVLAATFspRTSSL-SPSRFLVALLASANLLTGVYVAALTLLDTVTwgsfaeyGVWWETGAGCQVVGFL 613
Cdd:cd00637     7 LIFVVGLVGNLLVILVIL--RNRRLrTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-------GRWWFGDALCKLLGFL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 614 AVFS-----------SewavlllalaaVERCLAV------RALMGKAGALrsrgerrerrrrfaIAALLLGLVSVAAACL 676
Cdd:cd00637    78 QSVSllasiltltaiS-----------VDRYLAIvhplryRRRFTRRRAK--------------LLIALIWLLSLLLALP 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 677 SLYHGSAM---GSPLCLPFSEGSSPGLGFTVALVLMNTLAYLLS-AVVYTRLYCRLGRAQLADPEQAGS----------- 741
Cdd:cd00637   133 PLLGWGVYdygGYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLViIVCYVRIFRKLRRHRRRIRSSSSNssrrrrrrrer 212

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207181426 742 --VRHIAWLIFTNCIFFCPVAAFSFAPLLAGTSNAVggPEMAKSVTLIFFPLSACLNPVLYVCFS 804
Cdd:cd00637   213 kvTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPL--PRILYFLALLLAYLNSAINPIIYAFFN 275
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-206 3.38e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  45 DCSGRGLTSVPTGLSAFTYYLDISMNNITELPANVFRNLPYLEELRlagNDLAFIhPEAL-SGLHQLKVlmlQNNQLKTV 123
Cdd:PRK15370  247 ELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTL-PAHLpSGITHLNV---QSNSLTAL 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 124 PSAALKNLNALQSlrlDANHITSVPEDSFEGLQQLRhlwLDDNSLTEVP--ISPlqhqsNLQALTLALNRITHIPDNAFA 201
Cdd:PRK15370  320 PETLPPGLKTLEA---GENALTSLPASLPPELQVLD---VSKNQITVLPetLPP-----TITTLDVSRNALTNLPENLPA 388


                  ....*
gi 1207181426 202 NLSSL 206
Cdd:PRK15370  389 ALQIM 393
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-270 7.05e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 7.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  65 LDISMNNI----TELPANVFRNLPYLEELRLAGNDL----AFIHPEALSGLHQLKVLMLQNNQLKTVPSAA----LKNLN 132
Cdd:COG5238   185 VYLGCNQIgdegIEELAEALTQNTTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaeaLKNNT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 133 ALQSLRLDANHITSvpedsfEGLQQLrhlwlddnsltevpISPLQHQSNLQALTLALNRITHIPDNAFANL----SSLVV 208
Cdd:COG5238   265 TVETLYLSGNQIGA------EGAIAL--------------AKALQGNTTLTSLDLSVNRIGDEGAIALAEGlqgnKTLHT 324

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207181426 209 LHLHNNRIQEIGKN----CFNGLDNLETLDLNFNNL-----KIFPEAIQMLPKLKELGFHSNNIAsiPEGA 270
Cdd:COG5238   325 LNLAYNGIGAQGAIalakALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIG--KQGA 393
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-241 8.19e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 8.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  40 EDGGADCSGRGLTSVPTGLSAftyyLDISMNNITELP----ANVFRNLPYLEELRLAGNDL---AFIH-PEALSGLHQLK 111
Cdd:cd00116   121 GDRGLRLLAKGLKDLPPALEK----LVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdaGIRAlAEGLKANCNLE 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 112 VLMLQNNQLKTVPSAALknlnalqslrldanhitsvpEDSFEGLQQLRHLWLDDNSLTEVPISplqhqsnlqALTLALNr 191
Cdd:cd00116   197 VLDLNNNGLTDEGASAL--------------------AETLASLKSLEVLNLGDNNLTDAGAA---------ALASALL- 246

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207181426 192 ithipdnafANLSSLVVLHLHNNRIQEIG-KNCFNGLDN---LETLDLNFNNLK 241
Cdd:cd00116   247 ---------SPNISLLTLSLSCNDITDDGaKDLAEVLAEkesLLELDLRGNKFG 291
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-172 1.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  65 LDISMNNITELpaNVFRNLPYLEELRLAGNDLA-----FIHPEALSGL-HQLKVLMLQNNQLKTVpsAALKNLNALQSLR 138
Cdd:cd21340    73 LYLGGNRISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLD 148

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207181426 139 LDANHITSVPE--DSFEGLQQLRHLWLDDNSLTEVP 172
Cdd:cd21340   149 ASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 202-429 1.74e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 202 NLSSLVVLHLHNNRIQ-EIGKNCFnGLDNLETLDLNFNNLKI-FPEAIQML-PKLKELGFHSNNIA-SIPEGAFcrnSLL 277
Cdd:PLN00113   67 NSSRVVSIDLSGKNISgKISSAIF-RLPYIQTINLSNNQLSGpIPDDIFTTsSSLRYLNLSNNNFTgSIPRGSI---PNL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 278 RTIHLFDNPLSFVGTTAFQNLSDLHSLMLRGASMMQDFP-SLTGTINLESLTLTGTK-IRSIPADLCEdLTVLRTVDLSY 355
Cdd:PLN00113  143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSLEFLTLASNQlVGQIPRELGQ-MKSLKWIYLGY 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207181426 356 NDIE-DLP-SFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSLA 429
Cdd:PLN00113  222 NNLSgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS 297
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 544-800 3.89e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 544 NCLVLAATFSPRtSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSfaeygvwWETG-AGCQVVGFLAVFSSEWAV 622
Cdd:pfam00001   2 NLLVILVILRNK-KLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 623 LLLALAAVERCLA-VRALMGKAgalrsrgerrerRRRFAIAALLLGLVSVAAACLSL---YHGSAMGSP-----LCLP-F 692
Cdd:pfam00001  74 LLLTAISIDRYLAiVHPLRYKR------------RRTPRRAKVLILVIWVLALLLSLpplLFGWTLTVPegnvtVCFIdF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 693 SEGSSPGLGFTvalVLMNTLAYLLS----AVVYTRLYCRL--GRAQLADPEQAGSVRHIAW----LIFTNCIFFCPVAAF 762
Cdd:pfam00001 142 PEDLSKPVSYT---LLISVLGFLLPllviLVCYTLIIRTLrkSASKQKSSERTQRRRKALKtlavVVVVFILCWLPYHIV 218

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1207181426 763 SFAPLLAGTSNAVGGPEMAKSVTLIFFPLSACLNPVLY 800
Cdd:pfam00001 219 NLLDSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 73-231 6.24e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.69  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  73 TELPANVFRNLPyLEELRLaGNDLAFIHPEALSGLHQLKVLMLQNNqLKTVPSAALKNLNaLQSLRLDANhITSVPEDSF 152
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITI-PSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAF 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207181426 153 EGLqqlrhlwlddNSLTEVPISplqhqsnlqaltlalNRITHIPDNAFANlSSLVVLHLHNNrIQEIGKNCFNGLDNLE 231
Cdd:pfam13306  76 SNC----------SNLKSITLP---------------SNLTSIGSYAFSN-CSLKSITIPSS-VTTIGSYAFSNCSNLK 127
LRR_9 pfam14580
Leucine-rich repeat;
316-432 6.57e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 316 PSLTGTINLESLTLTGTKIRSIpADLCEDLTVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLR 395
Cdd:pfam14580  13 AQYTNPVRERELDLRGYKIPII-ENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLT 91

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1207181426 396 VLDLSRNQI-KFIHRDAFLSLSALTNLDLSLNSLASVP 432
Cdd:pfam14580  92 ELILTNNNLqELGDLDPLASLKKLTFLSLLRNPVTNKP 129
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 205-240 9.65e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 9.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207181426 205 SLVVLHLHNNRIQEIGKncFNGLDNLETLDLNFNNL 240
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 528-808 1.90e-04

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 44.39  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 528 MIRLTVWFICLVALLFNCLVLAATFSPRTSSLSPSrFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGC 607
Cdd:cd15966     2 ILRVFVWVMAFITCFGNLFVIGMRSFIRAENKTHA-MCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 608 QVVGFLAVFSSEWAVLLLALAAVERCLAVralmgkAGALRSRGERRERRRRFAIAALLLGLVSVAAACLSL-YHGSAMG- 685
Cdd:cd15966    81 RIIGFLAMLSTEVSVLLLTYLTLEKYLVI------VFPFSNIRPGKCQTLIILISIWLVGFIIAVIPFWNEdFFGNYYGk 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 686 SPLCLPFSEGSSP---GLGFTVALVL-MNTLAYLLSAVVYTRLYCRLGRAQLADPEQAGSV-RHIA------WLIFTNCI 754
Cdd:cd15966   155 NGVCFPLHSDQTEkigAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTEVRSHIhRDVAvanrffFIVFSDAI 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207181426 755 FFCPVAAFSFAPLLagtsnAVGGPEMAKSVTLIFF-PLSACLNPVLYVCFSPSFR 808
Cdd:cd15966   235 CWIPIFLLKILSLF-----QVEIPGTITSWIVIFIlPINSALNPILYTLTTSFFK 284
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 348-384 2.12e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 2.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1207181426 348 LRTVDLSYNDIEDLPSFQGCVRLQDINLQHN-QIKQID 384
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLS 40
PLN03150 PLN03150
hypothetical protein; Provisional
 101-172 3.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 3.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207181426 101 PEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHIT-SVPEdSFEGLQQLRHLWLDDNSLT-EVP 172
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPE-SLGQLTSLRILNLNGNSLSgRVP 507
LRR_8 pfam13855
Leucine rich repeat;
277-358 4.54e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 277 LRTIHLFDNPLSFVGTTAFQNLSdlhslmlrgasmmqdfpsltgtiNLESLTLTGTKIRSIPADLCEDLTVLRTVDLSYN 356
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 1207181426 357 DI 358
Cdd:pfam13855  60 RL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-233 9.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 9.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  49 RGLTSVPtglsaFTYYLDISMNNITELPANVFRNLPYLEELRLAGNDLAFIHPEALSglhqlkvlmlqnnqlktvpSAAL 128
Cdd:PLN00113  422 SEFTKLP-----LVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFG-------------------SKRL 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 129 KNLNalqslrLDANHITSVPEDSFEGLQQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRIT-HIPDnAFANLSSLV 207
Cdd:PLN00113  478 ENLD------LSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPA-SFSEMPVLS 550

                         170       180
                  ....*....|....*....|....*..
gi 1207181426 208 VLHLHNNRIQ-EIGKNcfngLDNLETL 233
Cdd:PLN00113  551 QLDLSQNQLSgEIPKN----LGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 64-118 1.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207181426  64 YLDISMNNITELpaNVFRNLPYLEELRLAGNDLAFIHP--EALSGLHQLKVLMLQNN 118
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
251-308 1.34e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207181426 251 PKLKELGFHSNNIASIPEGAFCRNSLLRTIHLFDNPLSFVGTTAFQNLSDLHSLMLRG 308
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 360-434 1.49e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 1.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207181426 360 DLPSFQgcvRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSLAS-VPTA 434
Cdd:PLN03150  437 DISKLR---HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAA 509
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 104-394 2.13e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.17  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  104 LSGLHQLKVLMLQN-NQLKTVPSAaLKNLNALQSLRLD-ANHITSVPedSFEGLQQLRHLWLDDNS-LTEVP-ISplqhq 179
Cdd:PLN03210   653 LSMATNLETLKLSDcSSLVELPSS-IQYLNKLEDLDMSrCENLEILP--TGINLKSLYRLNLSGCSrLKSFPdIS----- 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  180 SNLQALTLALNRITHIPDNAfaNLSSLVVLHLHNNRIQEIGKNCfNGLDNLETL------DLNFNNLKIF---PEAIQML 250
Cdd:PLN03210   725 TNISWLDLDETAIEEFPSNL--RLENLDELILCEMKSEKLWERV-QPLTPLMTMlspsltRLFLSDIPSLvelPSSIQNL 801

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426  251 PKLKELGF-HSNNIASIPEGAfcrnsllrtihlfdnplsfvgttafqNLSDLHSLMLRGASMMQDFPSLtgTINLESLTL 329
Cdd:PLN03210   802 HKLEHLEIeNCINLETLPTGI--------------------------NLESLESLDLSGCSRLRTFPDI--STNISDLNL 853

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207181426  330 TGTKIRSIPADLcEDLTVLRTVDLsyndiedlpsfQGCVRLQDINLQHNQIKQIDRGTFQGMTSL 394
Cdd:PLN03210   854 SRTGIEEVPWWI-EKFSNLSFLDM-----------NGCNNLQRVSLNISKLKHLETVDFSDCGAL 906
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
 529-617 2.89e-03

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 40.81  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 529 IRLTVWFI-CLVALLFNCLVLAATFSPRTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTwgsfaeygVWWETG-AG 606
Cdd:cd15383     2 VRVAVTFVlFVLSACSNLAVLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVT--------VQWYAGdLA 73

                          90
                  ....*....|.
gi 1207181426 607 CQVVGFLAVFS 617
Cdd:cd15383    74 CRLLMFLKLFA 84
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 392-426 4.58e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 4.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207181426 392 TSLRVLDLSRNQIKFIhrDAFLSLSALTNLDLSLN 426
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR smart00370
Leucine-rich repeats, outliers;
391-412 4.59e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.59e-03
                           10        20
                   ....*....|....*....|..
gi 1207181426  391 MTSLRVLDLSRNQIKFIHRDAF 412
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
391-412 4.59e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.59e-03
                           10        20
                   ....*....|....*....|..
gi 1207181426  391 MTSLRVLDLSRNQIKFIHRDAF 412
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 531-808 6.53e-03

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 39.47  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 531 LTVWFICLVALLFNCLVLAATFspRTSSL-SPSRFLVALLASANLLTGVYVAALTLLDTVtwgsfaeYGVWWETGAGCQV 609
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVY--RNRRLrTVTNYFIVSLAVADLLVALLVMPFSAVYTL-------LGYWPFGPVLCRF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 610 ---VGFLAVFSSEWAVLLLALaavERCLAV------RALMGKAGALrsrgerrerrrrFAIAALLlgLVSVAAACLSLYH 680
Cdd:cd14967    75 wiaLDVLCCTASILNLCAISL---DRYLAItrplryRQLMTKKRAL------------IMIAAVW--VYSLLISLPPLVG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207181426 681 GSAMGSPLCLPFSEGSSPGLGFTVALVlmnTLAYLLSAVVYTRLYCRLGRAqlADPEQAgSVRHIAWLIFTNCI----FF 756
Cdd:cd14967   138 WRDETQPSVVDCECEFTPNKIYVLVSS---VISFFIPLLIMIVLYARIFRV--ARRELK-AAKTLAIIVGAFLLcwlpFF 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207181426 757 C--PVAAFSFAPLLagtsnavggPEMAKSVTLIFFPLSACLNPVLYVCFSPSFR 808
Cdd:cd14967   212 IiyLVSAFCPPDCV---------PPILYAVFFWLGYLNSALNPIIYALFNRDFR 256
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 369-402 6.92e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 6.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1207181426 369 RLQDINLQHNQIKQIDrgTFQGMTSLRVLDLSRN 402
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 229-268 9.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 9.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1207181426 229 NLETLDLNFNNLKIFPeAIQMLPKLKELGFHSNN-IASIPE 268
Cdd:pfam12799   2 NLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNkITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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