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Conserved domains on  [gi|1207171093|ref|XP_021330601|]
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transcription factor GATA-3 isoform X5 [Danio rerio]

Protein Classification

GATA-type transcription factor( domain architecture ID 11526983)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator; similar to Mus musculus trans-acting T-cell-specific transcription factor GATA-3 isoform 4

Gene Ontology:  GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 9.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 9.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207171093 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
305-343 1.03e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


:

Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.83  E-value: 1.03e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207171093  305 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV 343
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGG 40
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 9.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 9.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207171093 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
251-299 3.60e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.98  E-value: 3.60e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207171093  251 SEGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 299
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
305-343 1.03e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.83  E-value: 1.03e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207171093  305 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV 343
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGG 40
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 309-343 6.04e-14

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 65.86  E-value: 6.04e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207171093 309 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNV 343
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGV 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 310-343 1.78e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.88  E-value: 1.78e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207171093 310 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNV 343
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 256-290 3.51e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.51e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207171093 256 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 290
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
249-334 1.13e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171093 249 SSSEGRECVNCGATSTPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWR 322
Cdd:COG5641   154 NSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTE 233

                          90
                  ....*....|..
gi 1207171093 323 RNANGDPVCNAC 334
Cdd:COG5641   234 SIGNSSASKLTK 245
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
309-343 8.14e-05

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 44.48  E-value: 8.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207171093 309 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNV 343
Cdd:COG5641   160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGS 199
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 255-305 9.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.95  E-value: 9.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207171093 255 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
251-299 3.60e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.98  E-value: 3.60e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207171093  251 SEGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 299
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
305-343 1.03e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.83  E-value: 1.03e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207171093  305 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV 343
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGG 40
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 309-343 6.04e-14

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 65.86  E-value: 6.04e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207171093 309 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNV 343
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGV 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 310-343 1.78e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.88  E-value: 1.78e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207171093 310 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNV 343
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 256-290 3.51e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.51e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207171093 256 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 290
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
249-334 1.13e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171093 249 SSSEGRECVNCGATSTPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWR 322
Cdd:COG5641   154 NSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTE 233

                          90
                  ....*....|..
gi 1207171093 323 RNANGDPVCNAC 334
Cdd:COG5641   234 SIGNSSASKLTK 245
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
242-342 7.95e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 47.56  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171093 242 KTRPKTRSSSEGREcVNCGATSTPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTSCANCQTTTTTL 320
Cdd:COG5641   288 STPKLVLPSDKKRS-TLTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNK 364

                          90       100
                  ....*....|....*....|..
gi 1207171093 321 WRRNANGdpvCNACGLYYKLHN 342
Cdd:COG5641   365 ILSPPTT---SNSPGAQVKLPN 383
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
309-343 8.14e-05

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 44.48  E-value: 8.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207171093 309 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNV 343
Cdd:COG5641   160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGS 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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