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Conserved domains on  [gi|1900293192|ref|XP_021163831|]
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gastrula zinc finger protein XlCGF57.1-like isoform X1 [Fundulus heteroclitus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-498 4.44e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 334 KPYICSVCSQGFSRNGDLKSHMR--IHTGE--KPFIC--SVCSQGFSRKGDLKRHIHFHTGEKPFIC--SVCSKGFSIKE 405
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 406 SLKRHVRVH-----TGEKPFICSV--CSKGFTQRESLKAHISVHTGKKP--FICSICRKGFSRKGDLKCHMRVHRGEKSF 476
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|..
gi 1900293192 477 ICsvCGQGFSRKAALKSHMHSH 498
Cdd:COG5048   448 LC--SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-383 2.50e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 210 PVRLHMIVHTGNVK-HSCDLCGKTFRVKSYLQTHMR--VHTGE--KPFACDV--CFKRFYATRTLKNHMKLHSVENPFSC 282
Cdd:COG5048   275 PNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 283 ELCGAGFKIK--------TRLEQHIWKHNgERPFVC--GICTKRFLHKHSLKIHLHVHTGEKPY--ICSVCSQGFSRNGD 350
Cdd:COG5048   355 KLLNSSSKFSpllnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1900293192 351 LKSHMRIHTGEKPFICSvCSQGFSRKGDLKRHI 383
Cdd:COG5048   434 LIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-498 4.44e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 334 KPYICSVCSQGFSRNGDLKSHMR--IHTGE--KPFIC--SVCSQGFSRKGDLKRHIHFHTGEKPFIC--SVCSKGFSIKE 405
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 406 SLKRHVRVH-----TGEKPFICSV--CSKGFTQRESLKAHISVHTGKKP--FICSICRKGFSRKGDLKCHMRVHRGEKSF 476
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|..
gi 1900293192 477 ICsvCGQGFSRKAALKSHMHSH 498
Cdd:COG5048   448 LC--SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-383 2.50e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 210 PVRLHMIVHTGNVK-HSCDLCGKTFRVKSYLQTHMR--VHTGE--KPFACDV--CFKRFYATRTLKNHMKLHSVENPFSC 282
Cdd:COG5048   275 PNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 283 ELCGAGFKIK--------TRLEQHIWKHNgERPFVC--GICTKRFLHKHSLKIHLHVHTGEKPY--ICSVCSQGFSRNGD 350
Cdd:COG5048   355 KLLNSSSKFSpllnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1900293192 351 LKSHMRIHTGEKPFICSvCSQGFSRKGDLKRHI 383
Cdd:COG5048   434 LIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHG 465
PHA00733 PHA00733
hypothetical protein
 391-450 7.46e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 7.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 391 PFICSVCSKGFSIKESLKRHVRVHTGEKpfICSVCSKGFTQRESLKAHISvhtgKKPFIC 450
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVC----KKHNIC 126
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1900293192 406 SLKRHVRVHTGEKPFICSVCSKGFTQ 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-261 5.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.64e-03
                          10        20
                  ....*....|....*....|....
gi 1900293192 238 YLQTHMRVHTGEKPFACDVCFKRF 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-498 4.44e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 334 KPYICSVCSQGFSRNGDLKSHMR--IHTGE--KPFIC--SVCSQGFSRKGDLKRHIHFHTGEKPFIC--SVCSKGFSIKE 405
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 406 SLKRHVRVH-----TGEKPFICSV--CSKGFTQRESLKAHISVHTGKKP--FICSICRKGFSRKGDLKCHMRVHRGEKSF 476
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|..
gi 1900293192 477 ICsvCGQGFSRKAALKSHMHSH 498
Cdd:COG5048   448 LC--SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-383 2.50e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 210 PVRLHMIVHTGNVK-HSCDLCGKTFRVKSYLQTHMR--VHTGE--KPFACDV--CFKRFYATRTLKNHMKLHSVENPFSC 282
Cdd:COG5048   275 PNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 283 ELCGAGFKIK--------TRLEQHIWKHNgERPFVC--GICTKRFLHKHSLKIHLHVHTGEKPY--ICSVCSQGFSRNGD 350
Cdd:COG5048   355 KLLNSSSKFSpllnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1900293192 351 LKSHMRIHTGEKPFICSvCSQGFSRKGDLKRHI 383
Cdd:COG5048   434 LIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-455 5.13e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 217 VHTGNVKHSCDLCGKTFRVKSYLQTHMRVHTGEKPFACDVCFKRFYATRTLKNHMKLHSVENPFSCELCGAGFKIKTRLE 296
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 297 QHIWKHNGER-------PFVCGICTKRFLHKHSLKIHL--HVHTGE--KPYIC--SVCSQGFSRNGDLKSHMRIHTGEKP 363
Cdd:COG5048   272 SSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 364 FIC--SVCSQGFSRKGDLKRH--IHFHTGEKPFICSVCSKGFSIK-----ESLKRHVRVHTGEKP--FICSVCSKGFTQR 432
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPqsLQQYKDLKNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         250       260
                  ....*....|....*....|...
gi 1900293192 433 ESLKAHISVHTGKKPFICSICRK 455
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-500 2.55e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 224 HSCDLCGKTFRVKSYLQTHMRVHTGEKPFACDV--CFKRFYATRTLKNHMKLHSVENPFSCELCGAGFKIKTR------- 294
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASssslsss 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 295 ---------LEQHIWKHNGERPFVCGICTKRFLHKHSLKIHLHVHTG-----EKPYICSVCSQGF--SRNGDLKSHMRIH 358
Cdd:COG5048   114 ssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnSLHPPLPANSLSKdpSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 359 TGEKPFICSVCSQGFSRKGDLKRHIHFHTGEKPFICSVCSKGF------SIKESLKRHVRVHTGEKPFICSVCSKGFTQR 432
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1900293192 433 ESLKAHISVHTGK-KPFICSICRKGFSRKGDLKCHMR--VHRGE--KSFIC--SVCGQGFSRKAALKSHMHSHTC 500
Cdd:COG5048   274 SPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-501 2.99e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 298 HIWKHNGERPFVCGICTKRFLHKHSLKIHLHVHTGEKPYICSVCSQGFSRNgdLKSHMRIHTGEKPFICSVCSQGFSRKG 377
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS--LLSQSPSSLSSSDSSSSASESPRSSLP 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 378 D----LKRHIHFHTGE-----KPFICSVCSKGFSIKESLKRHVR--VHTGE--KPFIC--SVCSKGFTQRESLKAHISVH 442
Cdd:COG5048   267 TassqSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 443 TGKKPFIC-------------------------------------SICRKGFSRKGDLKCHMRVHRGEKS--FICSVCGQ 483
Cdd:COG5048   347 TSISPAKEkllnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         250
                  ....*....|....*...
gi 1900293192 484 GFSRKAALKSHMHSHTCE 501
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNH 444
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 304-386 2.22e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 304 GERPFVCGI--CTKRFLHKHSLKIH-LHVHtgekpyicsvCSQGFSRNGDLKSHMRIHTGEKPFICSVCSQGFSRKGDLK 380
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1900293192 381 RHI-HFH 386
Cdd:COG5189   416 YHRkHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 342-439 4.02e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 342 SQGFSRNGDLKSHMRIHTGEKPFICSV--CSQGFSRKGDLKRH-IHFHTGEK--PFICSVCSKGFSIKEslkrhvrvhtg 416
Cdd:COG5189   328 AHGGERNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYHmLHGHQNQKlhENPSPEKMNIFSAKD----------- 396

                          90       100
                  ....*....|....*....|...
gi 1900293192 417 eKPFICSVCSKGFTQRESLKAHI 439
Cdd:COG5189   397 -KPYRCEVCDKRYKNLNGLKYHR 418
PHA00733 PHA00733
hypothetical protein
 391-450 7.46e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 7.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 391 PFICSVCSKGFSIKESLKRHVRVHTGEKpfICSVCSKGFTQRESLKAHISvhtgKKPFIC 450
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVC----KKHNIC 126
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-395 1.05e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1900293192 334 KPYICSVCSQGFSRNGDLKSHMRIHTGEKPFICSVCSQG--FSRKGDLKRHIHFHTGEKPFICS 395
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-415 1.54e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900293192 332 GEKPYICSV--CSQGFSRNGDLKSHMRihTGEkpficsvCSQGFSRKGDLKRHIHFHTGEKPFICSVCSKGFSIKESLKR 409
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML--HGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1900293192 410 HvRVHT 415
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1900293192 406 SLKRHVRVHTGEKPFICSVCSKGFTQ 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
306-367 4.57e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1900293192 306 RPFVCGICTKRFLHKHSLKIHLHVHTGEKPYICSVCSQG--FSRNGDLKSHMRIHTGEKPFICS 367
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-261 5.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.64e-03
                          10        20
                  ....*....|....*....|....
gi 1900293192 238 YLQTHMRVHTGEKPFACDVCFKRF 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 7.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1900293192 350 DLKSHMRIHTGEKPFICSVCSQGFSR 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 224-246 9.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.72e-03
                          10        20
                  ....*....|....*....|...
gi 1900293192 224 HSCDLCGKTFRVKSYLQTHMRVH 246
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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