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Conserved domains on  [gi|1196745448|ref|XP_021120534|]
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AP-3 complex subunit beta-2 isoform X6 [Heterocephalus glaber]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AP3B1_C super family cl20713
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
 1-40 1.37e-19

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


The actual alignment was detected with superfamily member pfam14796:

Pssm-ID: 464319  Cd Length: 148  Bit Score: 80.00  E-value: 1.37e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1196745448   1 MGTPKLPAGISIQEFPEIESLAPGESATAIMGINFCDSTQ 40
Cdd:pfam14796 109 IGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
 
Name Accession Description Interval E-value
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
 1-40 1.37e-19

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 80.00  E-value: 1.37e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1196745448   1 MGTPKLPAGISIQEFPEIESLAPGESATAIMGINFCDSTQ 40
Cdd:pfam14796 109 IGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
 
Name Accession Description Interval E-value
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
 1-40 1.37e-19

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 80.00  E-value: 1.37e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1196745448   1 MGTPKLPAGISIQEFPEIESLAPGESATAIMGINFCDSTQ 40
Cdd:pfam14796 109 IGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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