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Conserved domains on  [gi|1195684290|ref|XP_021035611|]
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N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein-like, partial [Mus caroli]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 34-238 2.35e-145

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03796:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 398  Bit Score: 411.63  E-value: 2.35e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLL 113
Cdd:cd03796     1 RICMVSDFFYPNLGGVETHIYQLSQCLIKRGHKVIVITHAYGNRVGVRYLTNGLKVYYLPFKVFYNQSTLPTLFSTFPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 114 RYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTV 193
Cdd:cd03796    81 RNILIRERIQIVHGHQAFSSLAHEALFHARTLGLKTVFTDHSLFGFADASSILTNKLLRFSLADIDHVICVSHTSKENTV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1195684290 194 LRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSVITVVVVSRLVYR 238
Cdd:cd03796   161 LRASLDPRIVSVIPNAVDSSDFTPDPSKPDPNKITIVVISRLVYR 205
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 34-238 2.35e-145

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 411.63  E-value: 2.35e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLL 113
Cdd:cd03796     1 RICMVSDFFYPNLGGVETHIYQLSQCLIKRGHKVIVITHAYGNRVGVRYLTNGLKVYYLPFKVFYNQSTLPTLFSTFPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 114 RYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTV 193
Cdd:cd03796    81 RNILIRERIQIVHGHQAFSSLAHEALFHARTLGLKTVFTDHSLFGFADASSILTNKLLRFSLADIDHVICVSHTSKENTV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1195684290 194 LRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSVITVVVVSRLVYR 238
Cdd:cd03796   161 LRASLDPRIVSVIPNAVDSSDFTPDPSKPDPNKITIVVISRLVYR 205
PIGA pfam08288
PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol ...
 72-161 5.25e-51

PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria.


Pssm-ID: 400541  Cd Length: 90  Bit Score: 160.88  E-value: 5.25e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  72 HAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLLRYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVF 151
Cdd:pfam08288   1 HAYGDRTGVRYLTNGLKVYYVPFLVIYRQSTFPTVFGTFPLFRNILLRERIDIVHGHGSFSTLAHEAILHARTMGLKTVF 80

                          90
                  ....*....|
gi 1195684290 152 TDHSLFGFAD 161
Cdd:pfam08288  81 TDHSLFGFAD 90
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 34-238 2.35e-145

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 411.63  E-value: 2.35e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLL 113
Cdd:cd03796     1 RICMVSDFFYPNLGGVETHIYQLSQCLIKRGHKVIVITHAYGNRVGVRYLTNGLKVYYLPFKVFYNQSTLPTLFSTFPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 114 RYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTV 193
Cdd:cd03796    81 RNILIRERIQIVHGHQAFSSLAHEALFHARTLGLKTVFTDHSLFGFADASSILTNKLLRFSLADIDHVICVSHTSKENTV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1195684290 194 LRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSVITVVVVSRLVYR 238
Cdd:cd03796   161 LRASLDPRIVSVIPNAVDSSDFTPDPSKPDPNKITIVVISRLVYR 205
PIGA pfam08288
PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol ...
 72-161 5.25e-51

PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria.


Pssm-ID: 400541  Cd Length: 90  Bit Score: 160.88  E-value: 5.25e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  72 HAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLLRYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVF 151
Cdd:pfam08288   1 HAYGDRTGVRYLTNGLKVYYVPFLVIYRQSTFPTVFGTFPLFRNILLRERIDIVHGHGSFSTLAHEAILHARTMGLKTVF 80

                          90
                  ....*....|
gi 1195684290 152 TDHSLFGFAD 161
Cdd:pfam08288  81 TDHSLFGFAD 90
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 34-238 5.51e-23

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 95.68  E-value: 5.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYnqstatTLFHSLPLL 113
Cdd:cd03801     1 KILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALL------RARRLLREL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 114 RYIFVRERITIIHSHSSFSAMAHDALFHAKtmGLQTVFTDHSLFGF------ADVSSVLTNKLLTVSLCDtnHIICVSYT 187
Cdd:cd03801    75 RPLLRLRKFDVVHAHGLLAALLAALLALLL--GAPLVVTLHGAEPGrlllllAAERRLLARAEALLRRAD--AVIAVSEA 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195684290 188 SKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRH---DSVITVVVVSRLVYR 238
Cdd:cd03801   151 LRDELRALGGIPPEKIVVIPNGVDLERFSPPLRRKLgipPDRPVLLFVGRLSPR 204
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
47-212 3.30e-19

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 81.42  E-value: 3.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  47 GGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTnglkVYYLPLRVMYNQSTATTLFHSLPLLRYIFVRERITIIH 126
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVR----VVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERPDVVH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 127 SHSSFSAMAhDALFHAKTMGLQTVFTDHSLF-------GFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALN 199
Cdd:pfam13439  77 AHSPFPLGL-AALAARLRLGIPLVVTYHGLFpdykrlgARLSPLRRLLRRLERRLLRRADRVIAVSEAVADELRRLYGVP 155

                         170
                  ....*....|...
gi 1195684290 200 PEIVSVIPNAVDP 212
Cdd:pfam13439 156 PEKIRVIPNGVDL 168
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 35-235 1.12e-18

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 83.17  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  35 ICMVSDFFYpnMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNqstattlfhSLPLLR 114
Cdd:cd03819     1 ILMLTPALE--IGGAETYILDLARALAERGHRVLVVTAGGPLLPRLRQIGIGLPGLKVPLLRALL---------GNVRLA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 115 YIFVRERITIIHSHSSFSAMAhdALFHAKTMGLQTVFTDHSLfgfaDVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVL 194
Cdd:cd03819    70 RLIRRERIDLIHAHSRAPAWL--GWLASRLTGVPLVTTVHGS----YLATYHPKDFALAVRARGDRVIAVSELVRDHLIE 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1195684290 195 RAALNPEIVSVIPNAVDPTDFTPDPFRRH-------DSVITVVVVSRL 235
Cdd:cd03819   144 ALGVDPERIRVIPNGVDTDRFPPEAEAEEraqlglpEGKPVVGYVGRL 191
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 34-237 2.30e-13

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 68.46  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYltnglKVYYLPLRVMYNQST-ATTLFHSLPL 112
Cdd:cd03817     1 KIAIFTDTYLPQVNGVATSVRNLARALEKRGHEVYVITPSDPGAEDEEE-----VVRYRSFSIPIRKYHrQHIPFPFKKA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 113 LRYIFVRERITIIHSHSSFSAMAHdALFHAKTMGLQTVFTDHSL---------FGFADVSSVLtnKLLTVSLCD-TNHII 182
Cdd:cd03817    76 VIDRIKELGPDIIHTHTPFSLGKL-GLRIARKLKIPIVHTYHTMyedylhyipKGKLLVKAVV--RKLVRRFYNhTDAVI 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195684290 183 CVSYTSKEntVLRAALNPEIVSVIPNAVDPTDFTPDP---FRRH----DSVITVVVVSRLVY 237
Cdd:cd03817   153 APSEKIKD--TLREYGVKGPIEVIPNGIDLDKFEKPLnteERRKlglpPDEPILLYVGRLAK 212
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 34-219 2.55e-13

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 68.52  E-value: 2.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLT-----NGLKVYYLPLRVMYNQSTATTLFH 108
Cdd:cd03794     1 KILLISQYYPPPKGAAAARVYELAKELVRRGHEVTVLTPSPNYPLGRIFAGatetkDGIRVIRVKLGPIKKNGLIRRLLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 109 --SLP---LLRYIFVRERITIIHSHSS--FSAMAhdALFHAKTMGLQTVFTDHSLFGFADVS-SVLTNKLL--------- 171
Cdd:cd03794    81 ylSFAlaaLLKLLVREERPDVIIAYSPpiTLGLA--ALLLKKLRGAPFILDVRDLWPESLIAlGVLKKGSLlkllkkler 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1195684290 172 -TVSLCDtnHIICVSYTSKENtVLRAALNPEIVSVIPNAVDPTDFTPDP 219
Cdd:cd03794   159 kLYRLAD--AIIVLSPGLKEY-LLRKGVPKEKIIVIPNWADLEEFKPPP 204
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 41-238 1.51e-10

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 60.06  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  41 FFYPNM--GGVESHIYQLSQCLIERGHKVitvtHAYGNRKGIRYLTN---GLKVYYLPLRVMYNQSTAttLFHSLPLLRY 115
Cdd:cd03811     4 FVIPSLsgGGAERVLLNLANALDKRGYDV----TLVLLRDEGDLDKQlngDVKLIRLLIRVLKLIKLG--LLKAILKLKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 116 IFVRERITIIHSHSSFSAmahDALFHAKTMGLQTVFTDHSlfgFADVSSVLTNKLLTVSLC--DTNHIICVSYTSKENTV 193
Cdd:cd03811    78 ILKRAKPDVVISFLGFAT---YIVAKLAAARSKVIAWIHS---SLSKLYYLKKKLLLKLKLykKADKIVCVSKGIKEDLI 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1195684290 194 LRAALNPEIVSVIPNAVDPTDFTPDP----FRRHDSVITVVVVSRLVYR 238
Cdd:cd03811   152 RLGPSPPEKIEVIYNPIDIDRIRALAkepiLNEPEDGPVILAVGRLDPQ 200
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 34-212 3.65e-10

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 58.88  E-value: 3.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  34 NICMVSDFFYPN-MGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHS--- 109
Cdd:cd03823     1 KILLVNSLYPPQrVGGAEISVHDLAEALVAEGHEVAVLTAGVGPPGQATVARSVVRYRRAPDETLPLALKRRGYELFety 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 110 ----LPLLRYIFVRERITIIHSHsSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVslcdtnhiICVS 185
Cdd:cd03823    81 npglRRLLARLLEDFRPDVVHTH-NLSGLGASLLDAARDLGIPVVHTLHDYWLLCPRQFLFKKGGDAV--------LAPS 151

                         170       180
                  ....*....|....*....|....*...
gi 1195684290 186 -YTskENTVLRAALNPEIVSVIPNAVDP 212
Cdd:cd03823   152 rFT--ANLHEANGLFSARISVIPNAVEP 177
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 45-235 1.27e-08

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 54.25  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  45 NMGGVESHIYQL--SQCLIERGHKVITVTH--AYGNRkgirYLTNGLKVYYLPLrvmynqstatTLFHSLP-LLRYI--F 117
Cdd:cd03807    10 NVGGAETMLLRLleHMDKSRFEHVVISLTGdgVLGEE----LLAAGVPVVCLGL----------SSGKDPGvLLRLAklI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 118 VRERITIIHSHssfsaMAHDALFHAKTMGLQ----TVFTDHSLFGFADVSSVL--TNKLLTVSLCDTnhiICVSYTSKEn 191
Cdd:cd03807    76 RKRNPDVVHTW-----MYHADLIGGLAAKLAggvkVIWSVRSSNIPQRLTRLVrkLCLLLSKFSPAT---VANSSAVAE- 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195684290 192 TVLRAALNPEIVSVIPNAVDPTDFTPDPFRRH---------DSVITVVVVSRL 235
Cdd:cd03807   147 FHQEQGYAKNKIVVIYNGIDLFKLSPDDASRArarrrlglaEDRRVIGIVGRL 199
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 45-238 5.68e-08

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 52.60  E-value: 5.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  45 NMGGVESHIYQLSQCLIERGHKVITVTHayGNRKGIRYLT-NGLKVYYLPLRV-----MYNqstattlFHSLPLLRYIFV 118
Cdd:cd03808     8 VDGGFQSFRLPLIKALVKKGYEVHVIAP--DGDKLSDELKeLGVKVIDIPILRrginpLKD-------LKALFKLYKLLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 119 RERITIIHSHSSFSAM-AHDALFHAKTMglQTVFTDHSLfGFADVSSVLTNKLLTV----SLCDTNHIICVSYTSKENTV 193
Cdd:cd03808    79 KEKPDIVHCHTPKPGIlGRLAARLAGVP--KVIYTVHGL-GFVFTEGKLLRLLYLLleklALLFTDKVIFVNEDDRDLAI 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1195684290 194 -LRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSVITVVVVSRLVYR 238
Cdd:cd03808   156 kKGIIKKKKTVLIPGSGVDLDRFQYSPESLPSEKVVFLFVARLLKD 201
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 47-219 1.15e-06

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 48.44  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  47 GGVESHIYQLSQCLIERGHKVITVthAYGNRKGIRyltNGLKVYYLPLRVMYNQSTATTLFHSLPLLRYIfVRERITIIH 126
Cdd:cd03802    18 GGTELVVSALTEGLVRRGHEVTLF--APGDSHTSA---PLVAVIPRALRLDPIPQESKLAELLEALEVQL-RASDFDVIH 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 127 SHSSFSamahdALFHAKTMGLQTVFTDHslfGFADVSSvltnkLLTVSLCDTNHIICVSYTSkentvlRAALNP-EIVSV 205
Cdd:cd03802    92 NHSYDW-----LPPFAPLIGTPFVTTLH---GPSIPPS-----LAIYAAEPPVNYVSISDAQ------RAATPPiDYLTV 152

                         170
                  ....*....|....
gi 1195684290 206 IPNAVDPTDFTPDP 219
Cdd:cd03802   153 VHNGLDPADYRFQP 166
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 45-237 1.92e-06

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 48.00  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  45 NMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLLRYIFVRER--I 122
Cdd:cd03820    11 NAGGAERVAINLANHLAKKGYDVTIISLDSAEKPPFYELDDNIKIKNLGDRKYSHFKLLLKYFKKVRRLRKYLKNNKpdV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 123 TIIHSHSSFSAMAhdalfhAKTMGLQTVFTDHSLFGFA-DVSSVLTNKLLTVSLCDTnhIICVSYTSKENTvlRAALNPE 201
Cdd:cd03820    91 VISFRTSLLTFLA------LIGLKSKLIVWEHNNYEAYnKGLRRLLLRRLLYKRADK--IVVLTEADKLKK--YKQPNSN 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1195684290 202 IVsVIPNAVDPTDFTP-DPFRRHdsviTVVVVSRLVY 237
Cdd:cd03820   161 VV-VIPNPLSFPSEEPsTNLKSK----RILAVGRLTY 192
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
47-156 2.70e-06

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 45.85  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  47 GGVESHIYQLSQCLIERGHKVITVTHAYGNRkGIRYLTNGLKVYYLPLRvmYNQSTATTLFHSLPLLRYIfVRERITIIH 126
Cdd:pfam13579   1 GGIGVYVLELARALAALGHEVRVVTPGGPPG-RPELVGDGVRVHRLPVP--PRPSPLADLAALRRLRRLL-RAERPDVVH 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1195684290 127 SHSSFSAMAhdALFHAKTMGLQTVFTDHSL 156
Cdd:pfam13579  77 AHSPTAGLA--ARLARRRRGVPLVVTVHGL 104
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 41-236 6.86e-06

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 46.22  E-value: 6.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  41 FFYPN--MGGVESHIYQLSQCLIERGHKVITVT------HAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPL 112
Cdd:cd03798     6 NIYPNanSPGRGIFVRRQVRALSRRGVDVEVLApapwgpAAARLLRKLLGEAVPPRDGRRLLPLKPRLRLLAPLRAPSLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 113 -LRYIFVRERITIIHSHSSFSAMAHDALFHAKTmGLQTVFTDHS--LFGFADVSSVLTNKLLTVSLCDtnhiiCVSYTSK 189
Cdd:cd03798    86 kLLKRRRRGPPDLIHAHFAYPAGFAAALLARLY-GVPYVVTEHGsdINVFPPRSLLRKLLRWALRRAA-----RVIAVSK 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195684290 190 E--NTVLRAALNPEIVSVIPNAVDPTDFTP--DPFRRHDSVITVVVVSRLV 236
Cdd:cd03798   160 AlaEELVALGVPRDRVDVIPNGVDPARFQPedRGLGLPLDAFVILFVGRLI 210
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 38-237 3.07e-05

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 44.19  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  38 VSDFFYPNMGGVESHIYQLSQCLIERGH--KVITVTHaygNRKGIRYLTNGLKVYYLPLRVMYNqstATTLFHSLPlLRY 115
Cdd:cd03795     5 VFKFYYPDIGGIEQVIYDLAEGLKKKGIevDVLCFSK---EKETPEKEENGIRIHRVKSFLNVA---STPFSPSYI-KRF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 116 IFVRERITIIHSHSSFSAMahDALFHAKTMGLQTVFTDHslfgfadvSSVLTNK--------LLTVSLCDTNHIICVSYT 187
Cdd:cd03795    78 KKLAKEYDIIHYHFPNPLA--DLLLFFSGAKKPVVVHWH--------SDIVKQKkllklykpLMTRFLRRADRIIATSPN 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195684290 188 SKENT-VLRAALNPeiVSVIPNAVDPTDFTPD----PFRRHDSVIT--VVVVSRLVY 237
Cdd:cd03795   148 YVETSpTLREFKNK--VRVIPLGIDKNVYNIPrvdfENIKREKKGKkiFLFIGRLVY 202
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 35-219 1.11e-04

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 42.74  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  35 ICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGIRYLTNGLKVYYLPLRVMYNQSTATTLFhslpLLR 114
Cdd:cd03809     2 ILIDGRSLAQRLTGIGRYTRELLKALAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRW----LQI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290 115 YIFVRERITIIHSHSSFSAMahdalfhaKTMGLQTVFTDHSLF------GFADVSSVLTNKLLTVSLCDTNHIICVSYTS 188
Cdd:cd03809    78 LLPKKDKPDLLHSPHNTAPL--------LLKGCPQVVTIHDLIplrypeFFPKRFRLYYRLLLPISLRRADAIITVSEAT 149

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1195684290 189 KENTVLRAALNPEIVSVIPNAVDPTDFTPDP 219
Cdd:cd03809   150 RDDIIKFYGVPPEKIVVIPLGVDPSFFPPES 180
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 35-160 9.46e-03

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 36.23  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195684290  35 ICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHaygnrkgiryltnglkvyylplrvmynqstattLFHSLPLLR 114
Cdd:cd01635     1 ILLVTGEYPPLRGGLELHVRALARALAALGHEVTVLAL---------------------------------LLLALRRIL 47

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195684290 115 YIFVRERITIIHSHSSFSAMAHdALFHAKTMGLQTVFTDHSLFGFA 160
Cdd:cd01635    48 KKLLELKPDVVHAHSPHAAALA-ALLAARLLGIPIVVTVHGPDSLE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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