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Conserved domains on  [gi|1195679774|ref|XP_021033364|]
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olfactory receptor 2B11 [Mus caroli]

Protein Classification

family 2 olfactory receptor( domain architecture ID 11610423)

family 2 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 29-298 4.58e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 477.50  E-value: 4.58e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 29-298 4.58e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 477.50  E-value: 4.58e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 39-309 1.07e-45

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 156.12  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  39 YILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 119 LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKLSCADTTA 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 199 NDA-TLAVLVAFFVLVPLaLILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL-----QPPSSYSQ 272
Cdd:pfam13853 165 NNIyGLFVVTSTFGIDSL-LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfgHNVPPLLQ 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 273 EQGKFISLFYSiitPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:pfam13853 244 IMMANAYLFFP---PVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 29-298 4.58e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 477.50  E-value: 4.58e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 31-305 4.03e-141

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 399.45  E-value: 4.03e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15434     3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15434    83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15434   163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15434   243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 29-305 7.92e-141

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 398.77  E-value: 7.92e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 29-298 5.38e-139

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 393.77  E-value: 5.38e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 29-305 2.14e-135

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 384.88  E-value: 2.14e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 32-298 1.54e-132

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 377.39  E-value: 1.54e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15237     4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15237    84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15237   164 ACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15237   244 PDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 30-298 3.10e-124

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 356.43  E-value: 3.10e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15230     2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15230    82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15230   162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15230   242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 31-305 1.47e-123

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 355.03  E-value: 1.47e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15231     3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15231    83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15231   163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15231   243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 31-305 2.02e-123

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 354.55  E-value: 2.02e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15421     3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15421    83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15421   163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15421   243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 30-298 2.85e-122

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 351.53  E-value: 2.85e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15431     2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQViLTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15431    82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15431   161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                         250       260
                  ....*....|....*....|....*....
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15431   241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 15-309 1.27e-120

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 348.20  E-value: 1.27e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  15 DFILLGISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQK 94
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  95 TISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCG 174
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 175 RQVLNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSL 254
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195679774 255 FYLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 16-302 7.48e-120

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 346.23  E-value: 7.48e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  16 FILLGISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKT 95
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGR 175
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 176 QVLNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF 255
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 32-305 9.90e-119

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 342.84  E-value: 9.90e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15429     4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15429    84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15429   164 ACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15429   244 ALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 29-307 3.10e-118

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 341.54  E-value: 3.10e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15417   241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 16-309 2.03e-117

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 340.02  E-value: 2.03e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  16 FILLGISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKT 95
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGR 175
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 176 QVLNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF 255
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195679774 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 30-305 1.42e-116

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 337.27  E-value: 1.42e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15235     3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15235    83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15235   163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15235   243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 30-305 6.95e-116

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 335.72  E-value: 6.95e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15229     2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15229    82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15229   162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15229   242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 31-305 2.90e-115

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 334.07  E-value: 2.90e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15433     3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15433    83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15433   163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15433   243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 29-307 7.92e-114

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 330.43  E-value: 7.92e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 32-305 2.21e-113

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 329.29  E-value: 2.21e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15420     4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15420    84 AHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15420   164 ACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15420   244 AEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 29-298 1.85e-112

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 326.75  E-value: 1.85e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 29-307 1.21e-111

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 325.03  E-value: 1.21e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15419   241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 32-298 1.19e-110

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 322.10  E-value: 1.19e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15227     4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15227    84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15227   164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15227   244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 29-298 1.28e-110

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 322.13  E-value: 1.28e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 29-307 5.36e-110

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 320.89  E-value: 5.36e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 32-298 8.54e-110

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 320.09  E-value: 8.54e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15430     4 FVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15430    84 GSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15430   164 ACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNA 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15430   244 QISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 29-298 3.28e-107

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 313.43  E-value: 3.28e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 31-305 4.03e-107

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 313.21  E-value: 4.03e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15424     3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15424    83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15424   163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15424   243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 32-298 6.16e-107

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 312.63  E-value: 6.16e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15918     4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15918    84 GDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15918   164 SCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15918   244 ASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 16-307 5.40e-106

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 310.91  E-value: 5.40e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  16 FILLGISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKT 95
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGR 175
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 176 QVLNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF 255
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 16-309 5.01e-103

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 303.63  E-value: 5.01e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  16 FILLGISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKT 95
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGR 175
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 176 QVLNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF 255
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195679774 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 31-298 6.51e-102

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 299.99  E-value: 6.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15915     3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15915    83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRI-QSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15915   163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                         250       260
                  ....*....|....*....|....*....
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15915   243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 29-307 6.93e-102

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 300.05  E-value: 6.93e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15416   241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 30-307 8.20e-102

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 300.09  E-value: 8.20e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15409     2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15409    82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15409   162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15409   242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 20-309 2.32e-101

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 299.28  E-value: 2.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  20 GISDRPWLELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYG 99
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 100 GCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLN 179
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 180 NFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPA 259
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195679774 260 IYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:cd15406   241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 32-298 2.67e-101

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 298.43  E-value: 2.67e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15224     4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15224    84 ACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15224   164 SCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15224   244 FDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 30-307 3.04e-100

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 296.16  E-value: 3.04e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15413     2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15413    82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15413   242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 30-305 1.12e-99

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 294.48  E-value: 1.12e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15234    82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15234   162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15234   242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 31-298 1.81e-99

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 293.62  E-value: 1.81e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15946     3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15946    83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15946   163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                         250       260
                  ....*....|....*....|....*...
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15946   243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 30-307 5.19e-99

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 292.78  E-value: 5.19e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd15415     2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15415    82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15415   162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195679774 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15415   242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 32-298 1.30e-96

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 286.52  E-value: 1.30e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15913     4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15913    84 GTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15913   164 SCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15913   244 TGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 31-298 4.42e-96

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 284.88  E-value: 4.42e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15939     3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15939    83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAvMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15939   163 LACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*...
gi 1195679774 271 SQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15939   242 PID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 31-305 1.09e-95

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 284.37  E-value: 1.09e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15428     3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15428    83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15428   163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15428   243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 29-311 1.76e-94

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 281.62  E-value: 1.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRLLAR 311
Cdd:cd15414   241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 29-298 1.83e-94

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 280.63  E-value: 1.83e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15226    81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADT-------TANDATLAvLVAFFVLvplaliLLSYGFIARAVmRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIY 261
Cdd:cd15226   161 IKLACTDTyvlelmvVANSGLIS-LVCFLLL------LISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIF 232

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 262 MYLQPPSSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15226   233 IYVWPFSTFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 30-305 7.27e-94

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 279.72  E-value: 7.27e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQ-KTISYGGCTVQYAIF 108
Cdd:cd15916     2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15916    82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15916   162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15916   242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 28-308 3.62e-93

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 278.20  E-value: 3.62e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  28 ELPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAI 107
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPA 187
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 188 MIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPP 267
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195679774 268 SSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRRL 308
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 32-298 3.09e-91

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 272.71  E-value: 3.09e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15914     4 FILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15914    84 GITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15914   164 ACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15914   244 LDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 32-298 1.66e-90

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 270.85  E-value: 1.66e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15940     4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15940    84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVmRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15940   164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSL-RKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFS 242

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15940   243 ED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 31-305 7.81e-88

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 264.35  E-value: 7.81e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15233     3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15233    83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15233   163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195679774 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15233   243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 29-298 1.51e-87

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 263.04  E-value: 1.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15936     1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15936    81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADT------TANDATLAVLVAFFVLvplaliLLSYGFIARAVmRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYM 262
Cdd:cd15936   161 IKLACTDTfllellMVSNSGLVTLLIFFIL------LISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYI 233

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195679774 263 YLQPPSSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15936   234 YARPFQTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 29-307 3.36e-87

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 262.74  E-value: 3.36e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 29-305 7.37e-87

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 261.97  E-value: 7.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15405     1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15405    81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15405   161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15405   241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 32-305 4.44e-86

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 259.70  E-value: 4.44e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15236     4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15236    84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15236   164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15236   244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 32-305 3.36e-85

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 257.75  E-value: 3.36e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15228     4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15228    84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPpsSYS 271
Cdd:cd15228   164 ACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TPS 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195679774 272 QEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15228   242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 29-305 7.76e-84

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 253.89  E-value: 7.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15942     1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15942    81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15942   161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 269 SYSqeQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15942   241 QDP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 32-305 6.68e-83

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 251.69  E-value: 6.68e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHS-PMYIFLSHLSFLDLCYTTTTVPQMLFNM-GSSQKTISYGGCTVQYAIFH 109
Cdd:cd15941     4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAFH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15941    84 FLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSs 269
Cdd:cd15941   164 KLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS- 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195679774 270 ySQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15941   243 -SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 32-298 7.39e-79

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 240.93  E-value: 7.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15938     4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15938    84 GAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCADTTANDATLAVLVAFFVLVPLALILLSYGFIaraVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15938   164 ACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP 240

                         250       260
                  ....*....|....*....|....*..
gi 1195679774 272 QEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15938   241 VD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 29-298 2.30e-78

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 240.02  E-value: 2.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15937     1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIArAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPS 268
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195679774 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15937   240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 29-298 6.97e-77

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 236.20  E-value: 6.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQL-HSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAI 107
Cdd:cd15935     1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPA 187
Cdd:cd15935    81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 188 MIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIArAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPP 267
Cdd:cd15935   161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIIL-TTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195679774 268 SSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15935   240 SSSSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 25-305 3.12e-68

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 214.46  E-value: 3.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  25 PWLELPvfavLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQ 104
Cdd:cd15223     1 HWLSLP----FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCE 184
Cdd:cd15223    77 MFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 185 VPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL 264
Cdd:cd15223   157 HMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1195679774 265 --QPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15223   237 tyRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 26-299 7.35e-66

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 207.91  E-value: 7.35e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15917     2 WLSIPFCAM----YLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIImhrpLCQQLVAMAWLSGFGNSLVQVI----LTVQLPFCGRQVLNNF 181
Cdd:cd15917    78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTI----LTNTVVGKIGLAILLRAVALIIplplLVRRLPYCGSNVISHS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 182 FCEVPAMIKLSCADTTANdATLAVLVAFFVLV-PLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAI 260
Cdd:cd15917   154 YCEHMAVVKLACGDTRVN-SIYGLFVALLIVGfDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPAL 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 261 YmylqppSSYSQEQGK--------FISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15917   233 F------SFLTHRFGHhvpphvhiLLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 26-301 1.51e-62

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 199.56  E-value: 1.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPvfavLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15950     2 WIAIP----FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15950    78 FFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIY-MYL 264
Cdd:cd15950   158 MAVVKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYT 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195679774 265 QppsSYSQEQGKFISL----FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15950   238 Q---RFGQGVPPHTQVlladLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 26-299 3.28e-60

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 193.66  E-value: 3.28e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFavllVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15221     2 WISIPFC----SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15221    78 FFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTANdaTLAVLVAFFVLVPL--ALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMY 263
Cdd:cd15221   158 MGIARLACADITVN--IWYGLTVALLTVGLdvVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSF 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 264 LqppssySQEQGKFISL--------FYSIITPTLNPFIYTLRNK 299
Cdd:cd15221   236 L------THRFGRHIPRhvhillanLYVLVPPMLNPIVYGVKTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 26-299 1.23e-59

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 192.09  E-value: 1.23e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAvllvSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15953     2 WISIPFCL----MYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15953    78 FFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTANdATLAVLVAFFVL-VPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL 264
Cdd:cd15953   158 MAVVKLACGDTTIN-RIYGLVVALLVVgLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195679774 265 Q-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15953   237 ThrfgqgiAPHIHI-----ILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 26-301 1.68e-59

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 191.82  E-value: 1.68e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15952     2 WIGFPFCAV----YLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIImhrpLCQQLVAMAWLSGFGNSLVQVI----LTVQLPFCGRQVLNNF 181
Cdd:cd15952    78 FFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTI----LTNKVISVIALGIVLRPLLLVLpfvfLILRLPFCGHNIIPHT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 182 FCEVPAMIKLSCADTTANDATLAVLVAFFVLvPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIY 261
Cdd:cd15952   154 YCEHMGIAKLACASIRINIIYGLFAISVLVL-DVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALF 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 262 MYLQppSSYSQEQGKFISL----FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15952   233 SFLT--HRFGHNIPRYIHIllanLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 26-301 5.10e-58

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 187.94  E-value: 5.10e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15951     2 WISIPFCIM----YAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15951    78 FFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTANDAtLAVLVAFFVL-VPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL 264
Cdd:cd15951   158 MAVVKLACADTRVSRA-YGLSVAFLVGgLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 265 Q-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15951   237 ThrfghnvPPHVHI-----LIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 25-299 1.93e-57

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 186.55  E-value: 1.93e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  25 PWLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQML----FNmgssQKTISYGG 100
Cdd:cd15222     1 HWISIPFCLL----YLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLgifwFN----AREISFDA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 101 CTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNN 180
Cdd:cd15222    73 CLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSH 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 181 FFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAI 260
Cdd:cd15222   153 SYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMI 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 261 -----YMYLQPPSSYSQeqgKFISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15222   233 glsmvHRFGKHASPLVH---VLMANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 25-302 1.38e-50

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 168.93  E-value: 1.38e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  25 PWLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQ 104
Cdd:cd15948     2 PWISIPFCSA----FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIImhrpLCQQLVAMAWLSGFGNSLVQVI----LTVQLPFCGRQVLNN 180
Cdd:cd15948    78 MFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATI----LTNSVITKIGLAALARAVTLMTplpfLLRRLPYCRSHVIAH 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 181 FFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAI 260
Cdd:cd15948   154 CYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVV 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195679774 261 YmylqppSSYSQEQGK--------FISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15948   234 L------SSTMHRFARhvaphvhiLLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 26-301 1.05e-46

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 158.87  E-value: 1.05e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15956     2 WLSLPFCFI----YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15956    78 FLVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQ 265
Cdd:cd15956   158 MAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLM 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195679774 266 PPSSYSQEQGKFISL--FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15956   238 HRFGHSVPSAAHVLLsnLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 39-309 1.07e-45

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 156.12  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  39 YILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 119 LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKLSCADTTA 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 199 NDA-TLAVLVAFFVLVPLaLILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL-----QPPSSYSQ 272
Cdd:pfam13853 165 NNIyGLFVVTSTFGIDSL-LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfgHNVPPLLQ 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 273 EQGKFISLFYSiitPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:pfam13853 244 IMMANAYLFFP---PVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 13-302 2.44e-45

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 155.71  E-value: 2.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  13 PKDFILLGI----SDRPWLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFN 88
Cdd:cd15949     1 PSTFILLGIpglePLHVWISIPFCSM----YLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  89 MGSSQKTISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTV 168
Cdd:cd15949    77 FWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 169 QLPFCGRQVLNNFFCEVPAMIKLSCADTTANDaTLAVLVAFFVLVPLAL-ILLSYGFIARAVMRIQSSRGRHKAFGTCSS 247
Cdd:cd15949   157 RLPWYRTNIIAHSYCEHMAVVGLACGDVSINN-HYGLTIGFLVLIMDSLfIVLSYIMILRVVQRLATSEARLKTFGTCVS 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 248 HLLVVSLFYLPAIYMYLQ-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15949   236 HVCAILAFYVPIAVSSLIhrfgqnvPPPTHI-----LLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 26-301 4.47e-41

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 144.20  E-value: 4.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15954     2 WISIPFCFM----YIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15954    78 FFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 186 PAMIKLSCADTTAnDATLAVLVAFFVLV-PLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYL 264
Cdd:cd15954   158 MSVVKLACANIRV-DAIYGLMVALLIGGfDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFF 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195679774 265 Q--------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15954   237 AhrfgghhiTPHIHI-----IMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 26-301 4.66e-38

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 136.05  E-value: 4.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVllvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQY 105
Cdd:cd15955     2 WIGIPFCIM----FLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSG-FGNSLVQVILTVQLPFCGRQVLNNFFCE 184
Cdd:cd15955    78 FFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAvVLIIPCPLLIKLRLHHFRSTVISHSYCE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 185 VPAMIKLSCADTTANDAtLAVLVAFFVL-VPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMY 263
Cdd:cd15955   158 HMAVVKLAADDVRVNKI-YGLFVAFSILgFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSF 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195679774 264 LQ-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15955   237 FAhrfghhvAPYVHI-----LLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 45-294 9.51e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 134.73  E-value: 9.51e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  45 GNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQML-FNMGSSQKTISYGGCTVQYAIFHWLGCTECVVLAAMA 123
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 124 LDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRqvlNNFFCEVPAMIKLSCadttanDATL 203
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK------PVSY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 204 AVLVAFFV-LVPLALILLSYGFIARAVMRIQSSRGR-------HKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYSQEQG 275
Cdd:pfam00001 152 TLLISVLGfLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 231

                         250       260
                  ....*....|....*....|....*
gi 1195679774 276 KFISLFYSII------TPTLNPFIY 294
Cdd:pfam00001 232 RLLDKALSVTlwlayvNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 32-298 1.94e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 102.75  E-value: 1.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd00637     2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIkl 191
Cdd:cd00637    82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 scadttandATLAVLVAFFVLVPLALILLSYGFIARAV--------------MRIQSSRGRHKAFGTCSSHLLVVSLFYL 257
Cdd:cd00637   160 ---------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirssssnsSRRRRRRRERKVTKTLLIVVVVFLLCWL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195679774 258 P----AIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd00637   231 PyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 33-305 9.12e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 70.31  E-value: 9.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVqYAIFH-WL 111
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVI-YGFAVtFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCqQLVAMAWLSGFGNSLvqviltvqLPFCGrqvLNNFfceVPAMIKL 191
Cdd:cd14969    84 GLVSISTLAALAFERYLVIVRPLKAFRLSKRRAL-ILIAFIWLYGLFWAL--------PPLFG---WSSY---VPEGGGT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 192 SCA----DTTANDAT-LAVLVAFFVLVPLALILLSYGFIA---RAVMRIQSSRGRHKAFGTCSSH--------LLVVSLF 255
Cdd:cd14969   149 SCSvdwySKDPNSLSyIVSLFVFCFFLPLAIIIFCYYKIYrtlRKMSKRAARRKNSAITKRTKKAekkvakmvLVMIVAF 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1195679774 256 ---YLP----AIYMYLQPPSSysqeqgkfISLFYSIITPTL-------NPFIYTLRNKDVKGAL 305
Cdd:cd14969   229 liaWTPyavvSLYVSFGGEST--------IPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 33-231 4.74e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 65.43  E-value: 4.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15083     5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLsgfgNSLVQVIltvqLPFCGrqvLNNFfceVPAMIKLS 192
Cdd:cd15083    85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL----YSLLWVL----PPLFG---WSRY---VLEGLLTS 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 193 C-----ADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMR 231
Cdd:cd15083   151 CsfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR 194
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 31-305 1.84e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 60.27  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYIL-AMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd14967     1 LLAVFLSLIILvTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTvqlpfcgrqvlnNFFCEVPAMI 189
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGW------------RDETQPSVVD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDATLAVLVAFFvlVPLALILLSYGFIARAVMRiqssrgRHKAFGTCSshlLVVSLFY---LPAIYMYLqp 266
Cdd:cd14967   149 CECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLlcwLPFFIIYL-- 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195679774 267 pSSYSQEQGKFISLFYSIIT------PTLNPFIYTLRNKDVKGAL 305
Cdd:cd14967   216 -VSAFCPPDCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 33-247 8.01e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 58.93  E-value: 8.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFNMGSSQ-------KTISYGGCTVQ 104
Cdd:cd14986     5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVlTQIIWEATGEWvagdvlcRIVKYLQVVGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAifhwlgctECVVLAAMALDRYVAICEPLRYAiiMHRPLCQQLVAMAWLSGFGNSLVQVILTVQlpfcgRQVLNNFFce 184
Cdd:cd14986    85 FA--------STYILVSMSLDRYQAIVKPMSSL--KPRKRARLMIVVAWVLSFLFSIPQLVIFVE-----RELGDGVH-- 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195679774 185 vpamiklSCADTTANDATLAVLV---AFFVLV-PLALILLSYGFIARAV-MRIQSSRGRHKAFGTCSS 247
Cdd:cd14986   148 -------QCWSSFYTPWQRKVYItwlATYVFViPLIILSYCYGRILRTIwIRSRQKTDRPIAPTAMSC 208
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 33-231 1.02e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 58.01  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFN-----MGSSQ--KTISYGGCTVQ 104
Cdd:cd15196     5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVlPQLIWDityrfYGGDLlcRLVKYLQVVGM 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAifhwlgctECVVLAAMALDRYVAICEPLRYAIIMHRPlCQQLVAMAWLSGFGNSLVQVILtVQLPFCGRQVLNnffce 184
Cdd:cd15196    85 YA--------SSYVLVATAIDRYIAICHPLSSHRWTSRR-VHLMVAIAWVLSLLLSIPQLFI-FSYQEVGSGVYD----- 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 185 vpamiklsCADTTANDATLAVLVAFFV----LVPLALILLSYGFIARAVMR 231
Cdd:cd15196   150 --------CWATFEPPWGLRAYITWFTvavfVVPLIILAFCYGRICYVVWR 192
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 29-305 1.41e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 54.95  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmLFNMGSSQKTISYGGCTV----- 103
Cdd:cd14968     1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFmaclv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 104 ----QYAIFHwlgctecvvLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLvqviltvqLPFCGrqvLN 179
Cdd:cd14968    79 lvltQSSIFS---------LLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFG---WN 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 180 NFFCEVPAMIK--LSCADTTANDATLAVLVAFF--VLVPLALILLSYGFIARAVMR-----------IQSSRGRHKAFGT 244
Cdd:cd14968   139 NGAPLESGCGEggIQCLFEEVIPMDYMVYFNFFacVLVPLLIMLVIYLRIFRVIRKqlrqiesllrsRRSRSTLQKEVKA 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1195679774 245 CSSHLLVVSLFYLPAIYMY------LQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd14968   219 AKSLAIILFLFALCWLPLHiincitLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 30-243 1.11e-07

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 52.11  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLcYTTTTVPQMLFNMGSSqKTISYGGCTVQYAIFH 109
Cdd:cd15928     2 AVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRY-RPWRFGDLLCRLMYFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPA 187
Cdd:cd15928    80 SETCTYASILhiTALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195679774 188 miklscADTTANDATLAVLVAFFvLVPLALILLSYGFIARAVMRiqsSRGRHKAFG 243
Cdd:cd15928   160 ------VSSGLLSVMLWVSTSFF-FVPMVCLSLLYGLIGRALWD---RRQRSRTAG 205
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 31-299 1.53e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 51.83  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVL-LVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlFNMGSS-QKTISYGGCTVQYAIF 108
Cdd:cd14993     2 VLIVLyVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMP---LTLLENvYRPWVFGEVLCKAVPY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 hwlgcTECVV-------LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWlsgfgnsLVQVILTVQLPFCGRQVLNNF 181
Cdd:cd14993    79 -----LQGVSvsasvltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW-------VIAIIIMLPLLVVYELEEIIS 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 182 FCEVPAMIKLsCADT-TANDATLAVLVAFFV---LVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLL------- 250
Cdd:cd14993   147 SEPGTITIYI-CTEDwPSPELRKAYNVALFVvlyVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILrskkkva 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1195679774 251 -----VVSLF-------YLPAIYMYLQPPSS-YSQEQGKFISLF---YSIITPTLNPFIYTLRNK 299
Cdd:cd14993   226 rmlivVVVLFalswlpyYVLSILLDFGPLSSeESDENFLLILPFaqlLGYSNSAINPIIYCFMSK 290
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 34-305 1.80e-07

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 51.44  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQK-TISYGGCTVQYAIFHWLG 112
Cdd:cd15305     6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGnslvqviLTVQLPFCGRQVLNNFFcevpamIKLS 192
Cdd:cd15305    86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG-------ISMPIPVIGLQDDEKVF------VNGT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 CADTTANDATLAVLVAFFvlVPLALILLSYGFIARAVMRIQS---SRGRHKAFGTCSSHLLVV-SLFYLPAIYMYLQPPS 268
Cdd:cd15305   153 CVLNDENFVLIGSFVAFF--IPLIIMVITYCLTIQVLQRQQAinnERRASKVLGIVFFLFLIMwCPFFITNILSVLCKEA 230

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 269 SYSQEQGKFISLFYSI--ITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15305   231 CDQKLMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRAF 269
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 29-304 4.76e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 50.19  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIF 108
Cdd:cd15063     1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFgnslvqviLTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15063    81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF--------VICFPPLVGWNDGKDGIMDYSGS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 IKLSCADTTAND---ATLAVLVAFFvlVPLALILLSYGFIARAvmriqsSRGRHKAFGTCSshlLVVSLF---YLPAIYM 262
Cdd:cd15063   153 SSLPCTCELTNGrgyVIYSALGSFY--IPMLVMLFFYFRIYRA------ARMETKAAKTVA---IIVGCFifcWLPFFTV 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 263 YLQPPSSYSQEQGKFISLFYSI--ITPTLNPFIYTLRNKDVKGA 304
Cdd:cd15063   222 YLVRAFCEDCIPPLLFSVFFWLgyCNSALNPCIYALFSRDFRFA 265
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 33-164 6.11e-07

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 50.20  E-value: 6.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFNMgssqkTISYGGCTVQYAIFHWL 111
Cdd:cd15387     5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDI-----TFRFYGPDFLCRLVKYL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195679774 112 GC----TECVVLAAMALDRYVAICEPLRYaiiMHRPLCQQLVAMAWLSGFGNSLVQV 164
Cdd:cd15387    80 QVvgmfASTYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQV 133
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 26-299 7.32e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.70  E-value: 7.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVLlvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDL-----CYTTTTVPQMLFNMgssqktisYGG 100
Cdd:cd15206     1 ELIIPLYSVI---FLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLllavfCMPFTLVGQLLRNF--------IFG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 101 CTVQYAIFHWLGCTECV---VLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFgnslvqvilTVQLPFCGRQV 177
Cdd:cd15206    70 EVMCKLIPYFQAVSVSVstfTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSF---------LIMSPILVFSN 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 178 LNNFFCEVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVmrIQSSRGRHKAFgtcsshLLVVSLFYL 257
Cdd:cd15206   141 LIPMSRPGGHKCREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTL--LEAKKRVIRML------FVIVVEFFI 212

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 258 PAIYMY-------LQPPSSYSQEQGKFISLFY--SIITPTLNPFIYTLRNK 299
Cdd:cd15206   213 CWTPLYvintwkaFDPPSAARYVSSTTISLIQllAYISSCVNPITYCFMNK 263
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 31-229 1.01e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 49.33  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15336     3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVqviltvqlPFCGrqvlnnFFCEVPAMIK 190
Cdd:cd15336    83 FGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLP--------PLFG------WSAYVPEGLL 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 191 LSCA-----DTTANDATLAVLVAFFVLVPLALILLSYGFIARAV 229
Cdd:cd15336   149 TSCTwdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAI 192
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 39-305 1.42e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 48.98  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  39 YILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:cd15012    10 FCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 119 LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNffcevpamIKLSCADTTA 198
Cdd:cd15012    90 LVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE--------EEICVLDREM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 199 NDATLAVLVAFFV--LVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLP--AIYMYlqppsSYSQEQ 274
Cdd:cd15012   162 FNSKLYDTINFIVwyLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLPyhARKMW-----QYWSEP 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195679774 275 GKFISLFYSIITP----------TLNPFIYTLRNKDVKGAL 305
Cdd:cd15012   237 YRCDSNWNALLTPltflvlyfnsAVNPLLYAFLSKRFRQSM 277
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 33-302 1.93e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.39  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLfnmgssqkTISYGGCTVQYAIFhWLG 112
Cdd:cd15069     5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFCTDFHSCL-FLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVV-------LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVqviltvqlPFCG----RQVLNNf 181
Cdd:cd15069    76 CFVLVLtqssifsLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLT--------PFLGwnkaMSATNN- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 182 fCEVPA-------MIKLSCADTTANDATLAVLVAFF--VLVPLALILLSYGFI----ARAVMRIQ----SSRGRHKAFGT 244
Cdd:cd15069   147 -STNPAdhgtnhsCCLISCLFENVVPMSYMVYFNFFgcVLPPLLIMLVIYIKIflvaCRQLQRTElmdhSRTTLQREIHA 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195679774 245 CSSHLLVVSLFYLPAIYMY-LQPPSSYSQEQGK-------FISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15069   226 AKSLAIIVGIFALCWLPVHiLNCITLFQPEFSKskpkwamNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 31-305 2.12e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.19  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15073     3 VAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCqQLVAMAWLSGFGNSLvqviltvqLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15073    83 FGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYT-VMILLAWTNAFFWAA--------MPLVGWASYALDPTGATCTIN 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFVlVPLALILLSYGFIARAVmriqssrgRHKAFGTCSSHLLV-------VSLFYLPAIYMY 263
Cdd:cd15073   154 WRKNDSSFVSYTMSVIVVNFI-VPLAVMFYCYYNVSRFV--------KKVLASDCLESVNIdwtdqndVTKMSVIMIVMF 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195679774 264 LQPPSSYS--------QEQGKfISLFYSIITPTL-------NPFIYTLRNKDVKGAL 305
Cdd:cd15073   225 LVAWSPYSivclwasfGEPKK-IPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 35-239 2.30e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 48.43  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  35 LLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVqYAIFHWL-GC 113
Cdd:cd15074     7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVF-YGFCGFLfGC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 114 TECVVLAAMALDRYVAICEPlRYAIIMHRPLCQQLVAMAWLSGFGNSLvqviltvqLPFCGrqvLNNFfceVPAMIKLSC 193
Cdd:cd15074    86 CSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAV--------APLVG---WGSY---GPEPFGTSC 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195679774 194 ------ADTTANDATLAVLVAFFV-LVPLALILLSYGFIARAVMRIQSSRGRH 239
Cdd:cd15074   151 sidwtgASASVGGMSYIISIFIFCyLLPVLIIVFSYVKIIRKVKSSRKRVAGF 203
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 33-166 2.63e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 48.26  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFNMgssqkTISYGG----C-TVQYa 106
Cdd:cd15386     5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLIWEI-----TYRFQGpdllCrAVKY- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195679774 107 iFHWLGC-TECVVLAAMALDRYVAICEPLRyaiIMHRPLCQQ--LVAMAWLSGFGNSLVQVIL 166
Cdd:cd15386    79 -LQVLSMfASTYMLIMMTVDRYIAVCHPLR---TLQQPSRQAylMIGATWLLSCILSLPQVFI 137
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 40-231 4.85e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 47.19  E-value: 4.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTvPQMLFNMGSSQKTISYGGCTVqYAIFHWL-GCTECVV 118
Cdd:cd15079    12 IVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQI-YAFLGSLsGIGSIWT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 119 LAAMALDRYVAICEPLRyAIIMHRPLCQQLVAMAWLSGFGNSLvqviltvqLPFCGrqVLNNFfceVPAMIKLSC----- 193
Cdd:cd15079    90 NAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWAL--------LPLLF--GWGRY---VPEGFLTSCsfdyl 155

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1195679774 194 ADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMR 231
Cdd:cd15079   156 TRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFA 193
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 34-305 4.95e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 47.23  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVP-QMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15304     6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWlsgfgnsLVQVILTVQLPFCGRQVLNNFFCEVpamiklS 192
Cdd:cd15304    86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFGLQDDSKVFKEG------S 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 CADTTANDATLAVLVAFFvlVPLALILLSYGFIARAVMR-IQSSRGRHKAFGTCSSHLLVV-SLFYLPAIYMYLQPPSSY 270
Cdd:cd15304   153 CLLADENFVLIGSFVAFF--IPLTIMVITYFLTIKSLQQsISNEQKASKVLGIVFFLFVVMwCPFFITNVMAVICKESCN 230

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 271 SQEQGKFISLFYSI--ITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15304   231 EVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSAF 267
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 30-296 5.26e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 47.35  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMgSSQKTISYG--GCTVQYAI 107
Cdd:cd14979     2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNF-WWQYPWAFGdgGCKLYYFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 108 FHwlGCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVIL--TVQLPFCGR-QVLNNFF 182
Cdd:cd14979    81 FE--ACTYATVLtiVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLmgIQYLNGPLPgPVPDSAV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 183 CEVPAMiklscaDTTANDATLAVLVAFFVLvPLALILLSYGFIARAV--MRIQSSRGRHKAFGTCSSHL----------- 249
Cdd:cd14979   159 CTLVVD------RSTFKYVFQVSTFIFFVL-PMFVISILYFRIGVKLrsMRNIKKGTRAQGTRNVELSLsqqarrqvvkm 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 250 --LVVSLF---YLPaiYMYLQPPSSYSQEQGKFISLFYSIITP----------TLNPFIYTL 296
Cdd:cd14979   232 lgAVVIAFfvcWLP--FHAQRLMFSYASKEDTFLFDFYQYLYPisgilfylssAINPILYNL 291
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 32-154 8.15e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 46.58  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDlCYTTTTVpqMLFNMGSSQKTISYGG---CTVQYAIF 108
Cdd:cd15312     4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITD-FLLGFLV--MPYSMVRSVESCWYFGdlfCKIHSSLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195679774 109 HWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWL 154
Cdd:cd15312    81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWS 126
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 30-157 1.35e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 45.73  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGC-TVQYAIF 108
Cdd:cd15001     1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkAVAYLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195679774 109 HWLGCTeCVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGF 157
Cdd:cd15001    81 LSFICS-VLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSA 128
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 38-305 1.47e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 45.74  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  38 SYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVqYAIFHWLGCTECV 117
Cdd:cd15330    10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDL-FIALDVLCCTSSI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 118 V-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVqviltvqlPFCGRQVlnnffcevPAMIKLSCADT 196
Cdd:cd15330    89 LhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP--------PMLGWRT--------PEDRSDPDACT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 197 TANDATLAVLVAFFVL-VPLALILLSYGFIARAVMRiqsSRGRHKAFGTCSSHLLVVSL-FYLPAIYMYLQPPSSYSQEQ 274
Cdd:cd15330   153 ISKDPGYTIYSTFGAFyIPLILMLVLYGRIFKAAAR---ERKTVKTLGIIMGTFILCWLpFFIVALVLPFCESTCHMPEL 229

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195679774 275 GKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15330   230 LGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 33-300 1.58e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 45.43  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmLFNMGSSQKTISYGGCTVQYAI-FHWL 111
Cdd:cd15061     4 SFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLP--LAIIRQLLGYWPLGSHLCDFWIsLDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 112 GCTECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFgnslvqviLTVQLPFCGrqvlnnFFCEVPAMIK 190
Cdd:cd15061    82 LCTASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVG------PSWHGRRGLG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFFvlVPLALILLSYGFIARAVMRIQssrgrhKAFGTCSshlLVVSLF---YLPAIYMYLQPP 267
Cdd:cd15061   148 SCYYTYDKGYRIYSSMGSFF--LPLLLMLFVYLRIFRVIAKER------KTAKTLA---IVVGCFivcWLPFFIMYLIEP 216

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195679774 268 ---SSYSQEQGKFIS---LFYSIItptlNPFIYTLRNKD 300
Cdd:cd15061   217 fcdCQFSEALSTAFTwlgYFNSVI----NPFIYAFYNKD 251
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 33-157 3.15e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 44.81  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFNMgssqkTISYGG----CTV--QY 105
Cdd:cd15385     5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVlPQLCWDI-----TYRFYGpdflCRIvkHL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195679774 106 AIFHWLGCTecVVLAAMALDRYVAICEPLRyaiIMHRPLCQQ--LVAMAWLSGF 157
Cdd:cd15385    80 QVLGMFAST--YMLVMMTADRYIAICHPLK---TLQQPTKRSylMIGSAWALSF 128
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 34-155 3.60e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 44.49  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQ--MLFNMGSSQKTISYGGCTVQYAIFHWL 111
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLEtiMIAVLNSGYLVISDQFIQHMDNVFDSM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195679774 112 GCTECVV----LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLS 155
Cdd:cd15352    86 ICISLVAsicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 29-153 4.49e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 44.40  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLcYTTTTVPQMLFNMGSSQKTIsYGGCTVQYAIF 108
Cdd:cd15132     1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDLYRLWKSRPWI-FGEFLCRLYHY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 109 HWLGCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAW 153
Cdd:cd15132    79 ISEGCTYATILhiTALSIERYLAICFPLRAKVLVTRRRVKCVIAALW 125
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 34-309 4.92e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 44.17  E-value: 4.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCtVQYAIFHWLGC 113
Cdd:cd15307     6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHC-LTWICLDVLFC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 114 TECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPfcgRQVLNNFFCEVPAMIKls 192
Cdd:cd15307    85 TASIMhLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIPDPVY-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 cadttandATLAVLVAFFVlvPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF-----YLPAIYMYLQPP 267
Cdd:cd15307   160 --------KLVGSIVCFYI--PLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPT 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 268 SSYSQE---QGKFISL--FYSIITPTLNPFIYTLRNKDVKGALRRLL 309
Cdd:cd15307   230 VCAECEeriSHWVFDVvtWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 35-304 5.40e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 43.84  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  35 LLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVP-QMLFNMGSSQKTISYGGCTVqYAIFHWLGC 113
Cdd:cd15052     7 LLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLL-WVTLDVLFC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 114 TECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPfcgRQVLNNffcevpamikLS 192
Cdd:cd15052    86 TASIMhLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT---TNVLNN----------GT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 CADTTANDATLAVLVAFFvlVPLALILLSYGfiaravMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYSQ 272
Cdd:cd15052   153 CVLFNPNFVIYGSIVAFF--IPLLIMVVTYA------LTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGLCEEC 224

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 273 EQ---GKFISLFYSI--ITPTLNPFIYTLRNKDVKGA 304
Cdd:cd15052   225 NCrisPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 32-166 5.43e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.95  E-value: 5.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  32 FAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTV-PQMLFNMGSSQ-------KTISYGGCTV 103
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVlTDIIWRITVEWragdfacKVIRYLQVVV 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195679774 104 QYAifhwlgctECVVLAAMALDRYVAICEPLRYAIIMHRplCQQLVAMAWLSGFGNSLVQVIL 166
Cdd:cd15197    84 TYA--------STYVLVALSIDRYDAICHPMNFSQSGRQ--ARVLICVAWILSALFSIPMLII 136
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 106-296 8.39e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 43.31  E-value: 8.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHWLGCTECVV----LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLvqVILTVQLPFCGRQVLNNF 181
Cdd:cd15055    74 KLHSSLDYILTSAsifnLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSS--VLLYDNLNQPGLIRYNSC 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 182 FCEVPAMIklscadtTANDATLAVLVAFFvlVPLALILLSYG--FIA--------RAVMRIQSSRGR---------HKAF 242
Cdd:cd15055   152 YGECVVVV-------NFIWGVVDLVLTFI--LPCTVMIVLYMriFVVarsqaraiRSHTAQVSLEGSskkvskkseRKAA 222

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195679774 243 GTCSSHLLVVSLFYLP-----AIYMYLQPPSSYSQeqgKFISLFYsiITPTLNPFIYTL 296
Cdd:cd15055   223 KTLGIVVGVFLLCWLPyyivsLVDPYISTPSSVFD---VLIWLGY--FNSCLNPLIYAL 276
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 30-154 8.66e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 43.59  E-value: 8.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILA-MLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlfnMGSsqkTISYGGctvqyaif 108
Cdd:cd15058     1 PGLLLLLALIILAiVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVP-----LGA---TIVVTG-------- 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 109 HW-LGCTECVV---------------LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWL 154
Cdd:cd15058    65 KWqLGNFWCELwtsvdvlcvtasietLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 33-302 1.00e-04

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 43.20  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCY--------TTTTVPQMLFNMGSSQKTISYGGCTVQ 104
Cdd:cd14999     4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYlltipfyvSTYFLKKWYFGDVGCRLLFSLDFLTMH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAIFhwlgctecvVLAAMALDRYVAICEPLRyAIIMHRPLCQQLVAMAWLSGFGNSLVQVIL----TVQLPFCGRQVLnn 180
Cdd:cd14999    84 ASIF---------TLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMirlvTVEDKSGGSKRI-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 181 ffcevpamiklsCADTTANDATLAVLVAFFV---LVPLALILLSYGFIARAVMRIQSSRG--------RHKAFGTCSSHL 249
Cdd:cd14999   152 ------------CLPTWSEESYKVYLTLLFStsiVIPGLVIGYLYIRLARKYWLSQAAASnssrkrlpKQKVLKMIFTIV 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 250 LVVSLFYLP-------AIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd14999   220 LVFWACFLPfwiwqllYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 31-154 1.36e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 42.82  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlFNMGSSQKTISYGG---CTVQYAI 107
Cdd:cd15317     3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHTGL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWL 154
Cdd:cd15317    80 DLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 40-231 1.56e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 42.69  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTtvpqmlfnMGSSQKTISyggCTVQYAIFHWLGC------ 113
Cdd:cd15337    12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAV--------NGFPLKTIS---SFNKKWIWGKVACelygfa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 114 ------TECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLsgfgNSLVQVIltvqLPFC--GRQVLNNFFCev 185
Cdd:cd15337    81 ggifgfMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWL----WSLLWSI----PPFFgwGRYVPEGFQT-- 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 186 pamiklSCA-DTTANDAT----LAVLVAFFVLVPLALILLSYGFIARAVMR 231
Cdd:cd15337   151 ------SCTfDYLSRDLNnrlfILGLFIFGFLCPLLIIIFCYVNIIRAVRN 195
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
 35-167 1.66e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 42.44  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  35 LLVSYILAMLGNISIILVSQLDSQLHSPMY-IFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGC 113
Cdd:cd15219     6 LVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTS 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195679774 114 TECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILT 167
Cdd:cd15219    86 NAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLS 139
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 40-300 2.08e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 42.44  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTtVPQMLFNMgSSQKTISYGG--CTVQYAIFHWLGCTECV 117
Cdd:cd15088    12 VVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLG-MPFLIHQF-AIDGQWYFGEvmCKIITALDANNQFTSTY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 118 VLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVlnnfFCevpaMIKLSCADTT 197
Cdd:cd15088    90 ILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTT----FC----YVSLPSPDDL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 198 ANDATLAVLVAFFvlVPLALILLSY----GFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMY------LQPP 267
Cdd:cd15088   162 YWFTIYHFILGFA--VPLVVITVCYililHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHvvqlvnLAMN 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195679774 268 S-SYSQEQGKFISLFYSIITPTLNPFIYTLRNKD 300
Cdd:cd15088   240 RpTLAFEVAYFLSICLGYANSCLNPFVYILVSEN 273
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 26-305 2.21e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 42.11  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  26 WLELPVFAVLlvsYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDL-----CYTTTTVPQML--FNMGSSQ-KTIS 97
Cdd:cd15979     1 TVRILLYSVI---FLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMgtFIFGEVIcKAVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  98 Y-GGCTVQYAIFHwlgctecvvLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVI--LTVQLPFCG 174
Cdd:cd15979    78 YlMGVSVSVSTFS---------LVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVysVTVPVPVGD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 175 RQVLNnffcevpaMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRhkafgTCSSHLLVVSL 254
Cdd:cd15979   149 RPRGH--------QCRHAWPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKKR-----VIRMLVVIVAM 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 255 FYLPAIYMY-------LQPPSSYSQEQGKFISLFY--SIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15979   216 FFLCWLPIFsantwraFDPLSAHRALSGAPISFIHllSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
 33-161 2.36e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.06  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqMLFNMGSSQKTISYG--GCTVQYAIFHW 110
Cdd:cd15212     5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-FAFLTLFSRPGWLFGdrLCLANGFFNAC 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAiiMHRPLCQQLVAMAWLSGFGNSL 161
Cdd:cd15212    84 FGIVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTALGFSL 132
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 34-305 2.70e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 41.89  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGC 113
Cdd:cd14972     4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 114 TECVVLAaMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLsgfgnslVQVILTVqLPFCGRqvlNNFFCEVPAMIKLSC 193
Cdd:cd14972    84 SAYSLLA-IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWV-------WSVLLAL-LPVLGW---NCVLCDQESCSPLGP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 194 ADTTandaTLAVLVAFFVLVPLALILLSY-----------GFIARAVMRI---QSSRGRHKAFgTCSSHLLVVSLFYLP- 258
Cdd:cd14972   152 GLPK----SYLVLILVFFFIALVIIVFLYvrifwclwrhaNAIAARQEAAvpaQPSTSRKLAK-TVVIVLGVFLVCWLPl 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195679774 259 AIYMYLQP--PSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd14972   227 LILLVLDVlcPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 27-174 3.08e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 41.65  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  27 LELPVFAVLLVsyiLAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQML----------FNMGSSQKTI 96
Cdd:cd15394     2 LIIPLYSLVVL---VGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLayafeprgwvFGRFMCYFVF 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195679774  97 SYGGCTVQYAIFhwlgctecvVLAAMALDRYVAICEPLRYAiiMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCG 174
Cdd:cd15394    79 LMQPVTVYVSVF---------TLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG 145
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 40-302 3.20e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 41.85  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLfnmgssqkTISYGGCTVQYAIFhWLGCTECVV- 118
Cdd:cd15068    12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--------TISTGFCAACHGCL-FIACFVLVLt 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 119 ------LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGnslvqVILTVQLPF--CGRQVLNNFFCEVPAMIK 190
Cdd:cd15068    83 qssifsLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA-----IGLTPMLGWnnCGQPKEGKNHSQGCGEGQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 LSCADTTANDATLAVLVAFF--VLVPLALILLSYGFIARAVMR------------IQSSRGRHKAFGTCSSHLLVVSLF- 255
Cdd:cd15068   158 VACLFEDVVPMNYMVYFNFFacVLVPLLLMLGVYLRIFLAARRqlkqmesqplpgERARSTLQKEVHAAKSLAIIVGLFa 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195679774 256 --YLPA----IYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15068   238 lcWLPLhiinCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 34-153 3.46e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 41.67  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSyilaMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqMLFNMGSSQKTISYG--GCTVqYAIFHWL 111
Cdd:cd15005    10 ILCVS----LAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGalSCKV-IAFLAVL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195679774 112 GCTECV-VLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAW 153
Cdd:cd15005    84 FCFHSAfTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
 40-227 3.85e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 41.35  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVVL 119
Cdd:cd15391    12 FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 120 AAMALDRYVAICEPLRYAIIMHRPLCqqLVAMAWLSGFGNSLVQViltvqlpFCGRQVLNNFFCEvpamIKLSCADTTAN 199
Cdd:cd15391    92 TAIGIDRFFAVIFPLRSRHTKSRTKC--IIASIWAISFSLSSVQL-------FAGRTQRYGQYSE----GRVLCGESWPG 158

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1195679774 200 DATLAVLVAFFVL-----VPLALILLSYGFIAR 227
Cdd:cd15391   159 PDTSRSAYTVFVMlltyiIPLLILTSTYGYVGF 191
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 40-165 5.12e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 40.94  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYA--IFHWLGCTECV 117
Cdd:cd15103    12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnVIDSMICSSLL 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 118 V----LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVI 165
Cdd:cd15103    92 AsicsLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII 143
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 33-154 5.80e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 40.80  E-value: 5.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVP-QMLFNMGSSQKTISYGGCTVQYAiFHWL 111
Cdd:cd15067     4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDVWHS-FDVL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 112 GCTECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWL 154
Cdd:cd15067    83 ASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 40-240 6.36e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 40.69  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNIsIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH-----WLGCT 114
Cdd:cd14978    12 IFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIyplanTFQTA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 115 ECVVLAAMALDRYVAICEPLRYaiimhRPLCQqlVAMAWLSGFGNSLVQVILTVQLPFcGRQVLNNFFCEVPAMIKLSCA 194
Cdd:cd14978    91 SVWLTVALTVERYIAVCHPLKA-----RTWCT--PRRARRVILIIIIFSLLLNLPRFF-EYEVVECENCNNNSYYYVIPT 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 195 DTTANDATLAV-----LVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHK 240
Cdd:cd14978   163 LLRQNETYLLKyyfwlYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLR 213
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 34-153 8.14e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 40.31  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYA--IFHWL 111
Cdd:cd15354     6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnVFDSL 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195679774 112 GCTECVV----LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAW 153
Cdd:cd15354    86 ICISVVAsmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
 33-222 8.17e-04

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 40.28  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15401     5 GVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWlsgfgnslvqvILTVQlpfcgrQVLNNFFCEV----PAM 188
Cdd:cd15401    85 IGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTW-----------VLTLA------AIVPNFFVGSlqydPRI 147

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1195679774 189 IKLSCADTTANDATLAVLVAFFVlVPLALILLSY 222
Cdd:cd15401   148 YSCTFAQTVSSSYTITVVVVHFI-VPLSIVTFCY 180
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 31-155 8.75e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 40.16  E-value: 8.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYIL-AMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlFNMGSSQKTISYGG---CTVqYA 106
Cdd:cd15062     2 VVGVALGAFILfAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP---FSATLEVLGYWAFGrifCDV-WA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195679774 107 IFHWLGCTECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLS 155
Cdd:cd15062    78 AVDVLCCTASIMsLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 31-305 9.07e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 40.17  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAiFHW 110
Cdd:cd15054     3 VAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYA-FDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15054    82 MCCSASILnLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLscaDTTANDATLAVLVAFFvlVPLALILLSYGFIARAvmriqsSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15054   162 RL---LVSLPYALVASCLTFF--LPSGAICFTYCRILLA------ARKALKASLTLGILLGMFFVTWLPFFVANVVQAVC 230

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195679774 270 YSQEQGKFISLFY-SIITPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15054   231 DCVSPGLFDVLTWlGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
 47-306 1.04e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 39.93  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  47 ISIILVSQldsQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFhwLGCTECVVL--AAMAL 124
Cdd:cd15334    22 ITAIIVTR---KLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD--ITCCTCSILhlSAIAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 125 DRYVAICEPLRYAIIMHRPLCQQLVAMAWLsgfgnslVQVILTVQLPFCGRQVLNNffcEVPAMIKLSCADTTandaTLA 204
Cdd:cd15334    97 DRYRAITDAVEYARKRTPKHAGIMIAVVWI-------ISIFISMPPLFWRHQTTSR---EDECIIKHDHIVFT----IYS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 205 VLVAFFVlvPLALILLSYGFIARAVMRiqsSRGRHKAFGTCSSHLLVVSL-FYLPAIYMYLQPPSSYSQEQGKFISlFYS 283
Cdd:cd15334   163 TFGAFYI--PLALILILYYKIYRAATR---ERKAATTLGLILGAFVICWLpFFVKEVIVNTCDSCYISEEMSNFLT-WLG 236

                         250       260
                  ....*....|....*....|...
gi 1195679774 284 IITPTLNPFIYTLRNKDVKGALR 306
Cdd:cd15334   237 YINSLINPLIYTIFNEDFKKAFQ 259
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 30-294 1.09e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 39.94  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  30 PVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFH 109
Cdd:cd14982     2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 WLGCTECVVLAAMALDRYVAICEPLRYAIImhRPLCQQLVAMA--WLSgfgnSLVQVILTVQLPFCGRQVLNNFFCevpa 187
Cdd:cd14982    82 INMYGSILFLTCISVDRYLAVVHPLKSRRL--RRKRYAVGVCAgvWIL----VLVASVPLLLLRSTIAKENNSTTC---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 188 MIKLSCADTTANDATLAVLVAFFVLvPLALILLSYGFIARAVMRI----QSSRGRHKAFGTCSSHLLVVSLFYLP----- 258
Cdd:cd14982   152 FEFLSEWLASAAPIVLIALVVGFLI-PLLIILVCYSLIIRALRRRskqsQKSVRKRKALRMILIVLAVFLVCFLPyhvtr 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195679774 259 AIYMYLQPPSSYSQEQGKFISLFYSIITPT------LNPFIY 294
Cdd:cd14982   231 ILYLLVRLSFIADCSARNSLYKAYRITLCLaslnscLDPLIY 272
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 33-307 1.21e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 39.82  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLG-NISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFN-MGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15306     4 ALLILMVIIPTIGgNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTiLFEAMWPLPLVLCPIWLFLDVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGnslvqviLTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15306    84 FSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIG-------IAIPVPIKGIETDVDNPNNITCVLT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 191 lscADTTANDATLAVLVAFFVlvPLALILLSYgFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15306   157 ---KERFGDFILFGSLAAFFT--PLAIMIVTY-FLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCD 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195679774 271 SQEQ---GKFISLFYSI--ITPTLNPFIYTLRNKDVKGALRR 307
Cdd:cd15306   231 SCNQttlQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
 40-222 1.26e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 39.56  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVVL 119
Cdd:cd15210    12 VVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 120 AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGnslVQVILTvqLPFCGRQVLNnffcevPAMIKLSCADTTAN 199
Cdd:cd15210    92 VLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFG---SFLPLW--LGIWGRFGLD------PKVCSCSILRDKKG 160

                         170       180
                  ....*....|....*....|...
gi 1195679774 200 DATLAVLVAFFVLVPLALILLSY 222
Cdd:cd15210   161 RSPKTFLFVFGFVLPCLVIIICY 183
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 31-157 1.26e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 39.83  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGN--ISIILVSQLDSQ-LHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAI 107
Cdd:cd15355     3 VTAIYLALFVVGTVGNsiTLYTLARKKSLQhLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYY 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 108 FHWLGCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGF 157
Cdd:cd15355    83 FLRDACTYATALnvASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASA 134
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 39-231 1.28e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 39.85  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  39 YILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDL-----CYTTTTVPQML--FNMGSSQ-KTISY-GGCTVQYAIFH 109
Cdd:cd15978    11 FLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmlclfCMPFTLIPNLLkdFIFGSAVcKTATYfMGISVSVSTFN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 110 wlgctecvvLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVpami 189
Cdd:cd15978    91 ---------LVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRL---- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1195679774 190 kLSCADTTANDATLAVLVAFFvLVPLALILLSYGFIARAVMR 231
Cdd:cd15978   158 -LWPNDVTQQSWYIFLLLILF-LIPGIVMMTAYGLISLELYR 197
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
 31-154 1.31e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 39.84  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlFNMGSSQKTISYGG---CTVQYAI 107
Cdd:cd15316     3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMP---FSTVRSVESCWYFGesfCTFHTCC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195679774 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWL 154
Cdd:cd15316    80 DVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
 33-230 1.32e-03

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 39.89  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15377     5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLsgfgnsLVQVILTVQLPFCGRQVLNNffcevpamIKLS 192
Cdd:cd15377    85 YGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWL------IVVVAISPILFYSGTGVRKN--------KTIT 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 193 CADTTANDATLA------VLVAFFVLVPLALILLSYGFIARAVM 230
Cdd:cd15377   151 CYDTTSDEYLRSyfiysmCTTVAMFCVPFILILGCYGLIVRALI 194
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 31-140 1.45e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYIL-AMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVqYAIFH 109
Cdd:cd15325     2 VLGVILGGFILfGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNI-WAAVD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1195679774 110 WLGCTECVV-LAAMALDRYVAICEPLRYAIIM 140
Cdd:cd15325    81 VLCCTASIMsLCIISIDRYIGVSYPLRYPSIM 112
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 29-305 1.60e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlfnMGSSQKTISYGG-----CTV 103
Cdd:cd15326     1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-----FSATLEILGYWVfgrifCDI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 104 qYAIFHWLGCTECVV-LAAMALDRYVAICEPLRYAIIMHRplcqqlvAMAWLSGFGNSLVQVILTVQlPFCGRQvlnnff 182
Cdd:cd15326    76 -WAAVDVLCCTASILsLCAISIDRYIGVRHSLQYPTIVTR-------KRAILALLGVWVLSTVISIG-PLLGWK------ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 183 cEVPAMIKLSCADTTAN-DATLAVLVAFFvlVPLALILLSYGFIARAVMRIQSSRGRHKAFGtcsshlLVVSLFYLPAIY 261
Cdd:cd15326   141 -EPAPPDDKVCEITEEPfYALFSSLGSFY--IPLIVILVMYCRVYIVALKFSREKKAAKTLG------IVVGMFILCWLP 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195679774 262 MYLQPPSSYSQEQGKFISLFYSII------TPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15326   212 FFIALPLGSLFSHLKPPETLFKIIfwlgyfNSCLNPIIYPCSSKEFKRAF 261
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
 33-258 1.74e-03

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 39.61  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTtVPQMLFNMGSSQKTIsYGG--CTVQYAIFHW 110
Cdd:cd15168     5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLS-LPFLIYYYANGDHWI-FGDfmCKLVRFLFYF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVLAAMALDRYVAICEPLRyAIIMHRPLCQQLVAMA-WLsgfgnsLVQVILTVQLPFCGRQVLNNffcevpami 189
Cdd:cd15168    83 NLYGSILFLTCISVHRYLGICHPLR-SLGKLKKRHAVAISVAvWI------LVLLQLLPILFFATTGRKNN--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 190 KLSCADTTANDA-------TLAVLVAFFvLVPLALILLSYGFIARAVMR----IQSSRGRHKAFGTCSSHLLVVSLFYLP 258
Cdd:cd15168   147 RTTCYDTTSPEElndyviySMVLTGLGF-LLPLLIILACYGLIVRALIRklgeGVTSALRRKSIRLVIIVLALFAVCFLP 225
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 40-302 2.09e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 38.99  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVVL 119
Cdd:cd15070    12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 120 AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRQVLNNFFCEVPAMIKLScadttan 199
Cdd:cd15070    90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRMD------- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 200 datLAVLVAFF--VLVPLALILLSYGFIARaVMRIQSSRG----------RHKAFGTCSSHLLVVSLF---YLP------ 258
Cdd:cd15070   163 ---YMVYFSFFtwILIPLVIMCALYVDIFY-IIRNKLSQNatgfretgafYGREFKTAKSLALVLFLFavcWLPlsiinc 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 259 AIYMYLQPPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15070   239 VVYFNPKVPKIAL-----YLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 33-135 2.24e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 39.20  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTtVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd14970     5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVDAYNM 83

                          90       100
                  ....*....|....*....|...
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLR 135
Cdd:cd14970    84 FTSIFCLTVMSVDRYLAVVHPVK 106
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 40-305 2.59e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.01  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYA--IFHWLGCTECV 117
Cdd:cd15351    12 LVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnVIDTMICSSVV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 118 ----VLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILtvqlpfcgrqvlnnffcevpamiklsc 193
Cdd:cd15351    92 sslsFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY--------------------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 194 adtTANDATLAVLVAFFVLVPLALILLSYGFIARA---VMRIQSSRGRHKAFGTCSSHLLVVSL-------------FYL 257
Cdd:cd15351   145 ---YNSNAVILCLIVFFLFMLVLMLVLYIHMFILAcrhSQSISSQQRRQCPHQQTASLKGAITLtillgifflcwgpFFL 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195679774 258 PAIYMYLQPPSSYSQEQGKFISLFYSII--TPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15351   222 HLTLIVTCPTHPFCLCYFKYFNLFLILIicNSIIDPLIYAFRSQELRKTL 271
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
 33-294 2.87e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 38.86  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSY----ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTV----Q 104
Cdd:cd15389     1 ALLIVAYsiiiVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLsrfaQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 105 YAIFHWLGCTecvvLAAMALDRYVAICEPLRYAIimhrPLCQQLVAMA--WLSGFgnslvqvilTVQLPFCGRQVLNNFF 182
Cdd:cd15389    81 YCSVYVSTLT----LTAIALDRHRVILHPLKPRI----TPCQGVVVIAiiWIMAS---------CLSLPHAIYQKLVEFE 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 183 CEVpAMIKLSC-------ADTTANDATLAVLVAFFVLvPLALILLSYGFIAR---------AVMRIQSSRGRHKAFGTCS 246
Cdd:cd15389   144 YSN-ERTRSRClpsfpepSDLFWKYLDLATFILQYVL-PLLIIGVAYTRVAKklwlrnaigDVTTEQYVAQRRKKKKTIK 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195679774 247 SHLLVVSLF---YLPA-IYMYLQPPSSYSQEQGKFISLFYSIITPT-LNPFIY 294
Cdd:cd15389   222 MLMLVVLLFaicWLPLnCYHVLLSSHPIRSNSALFFAFHWLAMSSTcYNPFIY 274
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 40-253 3.51e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 38.35  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  40 ILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVP-QMLFNMgssQKTISYGG--CtvqyaifHWLGCTEC 116
Cdd:cd15203    12 VLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTL---TKNWPFGSilC-------KLVPSLQG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 117 VV-------LAAMALDRYVAICEPLRYAIIMHRPLCqqLVAMAWLSGFGNSL-------VQVILTVQLPFCGRQvlnnff 182
Cdd:cd15203    82 VSifvstltLTAIAIDRYQLIVYPTRPRMSKRHALL--IIALIWILSLLLSLplaifqeLSDVPIEILPYCGYF------ 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195679774 183 cevpamiklsCADTTANDA-----TLAVLVAFFVLvPLALILLSYGFIARaVMRIQSSRGRHKAFGTCSSHLLVVS 253
Cdd:cd15203   154 ----------CTESWPSSSsrliyTISVLVLQFVI-PLLIISFCYFRISL-KLRKRVKKKRGKRTLSSRRRRSELR 217
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 33-234 4.29e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 38.31  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGN---ISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQ-YAIF 108
Cdd:cd15356     5 AVYALIWALGAAGNaltIHLVLKKRSLRGLQGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYPWVFGDLVCRgYYFV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 109 HWLgCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTvqlpfcGRQVLNNFFCEVP 186
Cdd:cd15356    85 RDI-CSYATVLniASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIM------GQKYELETADGEP 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195679774 187 AMIKLSCADTTANdATLAVLVAFFVLV----PLALILLSYGFIARAvMRIQS 234
Cdd:cd15356   158 EPSSRVCTVLVSR-ATLKVFIQVNAFVsfvlPLALIAFLNGVTVSH-LRIQS 207
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
 34-302 4.30e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 38.29  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYI-LAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15215     4 VLIVIFLcASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVQLPFCGRqvlnNFFCEVPamikls 192
Cdd:cd15215    84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDER----NALCSVI------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 cadTTANDATLAVLVAFFVLVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVV---SLFYLPAIYMYLQPPSS 269
Cdd:cd15215   154 ---WGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARRCYHCKAAKVIFIIIFSYVLSMgpySFLSVLAVWVDTQVPQW 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195679774 270 YSQeqgkfISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15215   231 VIS-----IILWLFFLQCCIHPYIYGYMHKSIK 258
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
 116-296 4.58e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 38.03  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 116 CVVLAAMALDRYVAICEPLRYaiIMHRplcQQLVAMA-----WLSGFGNSLVQVIL--TVQLPFCGRQVLnnffcevpam 188
Cdd:cd15095    88 CLTLTALSVDRYYAIVHPIRS--LRFR---TPRVAVVvsaciWIVSFLLSIPVAIYyrLEEGYWYGPQTY---------- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 iklsCADTTANDATLAVLVAFFVLV----PLALILLSYGFIARAV-------MRIQSSRGRHKAFGTCSSHLLVVSLFYL 257
Cdd:cd15095   153 ----CREVWPSKAFQKAYMIYTVLLtyviPLAIIAVCYGLILRRLwrrsvdgNNQSEQLSERALRQKRKVTRMVIVVVVL 228

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 258 PAI------------YMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTL 296
Cdd:cd15095   229 FAIcwlpnhvlnlwqRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAF 279
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
 29-166 5.36e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 38.06  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIiLVSQLDSQLH--SPMYIFLSHLSFLDLCYTTTTVPqmlfnmgssqKTISYGGcTVQya 106
Cdd:cd15382     1 LVSIIVYSVLFLIAAVGNLTV-LLILLRNRRRkrSRVNILLMHLAIADLLVTFIMMP----------LEIGWAA-TVA-- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195679774 107 ifhWLG----CTECV------------VLAAMALDRYVAICEPLRYAIIMHRplCQQLVAMAWLSGFGNSLVQVIL 166
Cdd:cd15382    67 ---WLAgdflCRLMLffrafglylssfVLVCISLDRYFAILKPLRLSDARRR--GRIMLAVAWVISFLCSIPQSFI 137
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
 29-135 5.72e-03

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 37.82  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  29 LPVFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTtvpqMLFNMGSSQKTISYGG--CTVQYA 106
Cdd:cd15923     1 LLQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS----LPFKMHSYRRESAGLQklCNFVLS 76

                          90       100
                  ....*....|....*....|....*....
gi 1195679774 107 IFHWLGCTECVVLAAMALDRYVAICEPLR 135
Cdd:cd15923    77 LYYINMYVSIFTITAISVDRYVAIRYPLR 105
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 31-227 6.86e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 37.65  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQ-----KTISYGGCTVQY 105
Cdd:cd14997     3 VSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpwllgEFMCKLVPFVEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 106 AIFHwlgcTECVVLAAMALDRYVAICEPL--RYAIIMHRPLCqqLVAMAWLSGFGNSLVQVILTVqlpfcgrQVLNNFFC 183
Cdd:cd14997    83 TVAH----ASVLTILAISFERYYAICHPLqaKYVCTKRRALV--IIALIWLLALLTSSPVLFITE-------FKEEDFND 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 184 EVPAMIKLSCADTTANDATLAVLVAFFVLVPLALILLSYGFIAR 227
Cdd:cd14997   150 GTPVAVCRTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVICR 193
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
 62-294 7.26e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 37.42  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  62 PMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAIIMH 141
Cdd:cd15372    33 PSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 142 RPLCQQLVAMAWLsgfGNSLVQVILTVQLPFCGRQVLNNffcevpamikLSCADTTANDATLAVLVAFFV-------LVP 214
Cdd:cd15372   113 RRFALCMCTAIWL---IAAALTLPLTLQRQSYPLERLNI----------TLCHDVLPLDEQDTYLFYYFAclavlgfLLP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 215 LALILLSYGFIARAVMRiqsSRGRH-KAFGTCSSHLLVVSLFYLPAIYMYLQPPSSYSQEQGK------FISLFYSIITP 287
Cdd:cd15372   180 LVVILFCYGSVLHTLLR---SGQRYgHAMKLTVLVLVSFVLCFTPSNLLLLLHYSDPTLDDGGnlyivyMVSLAISTLNS 256


                  ....*..
gi 1195679774 288 TLNPFIY 294
Cdd:cd15372   257 CVDPFIY 263
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 34-155 7.51e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.58  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  34 VLLVSYIL-AMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPqmlfnmgsSQKTISYGGCTVQYAIFH--W 110
Cdd:cd15327     5 VFLAIFILmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP--------FSATLEVLGFWAFGRVFCdiW 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195679774 111 -----LGCTECVV-LAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLS 155
Cdd:cd15327    77 aavdvLCCTASILsLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVS 127
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
 33-300 8.41e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 37.43  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  33 AVLLVSYILAMLGNISIILVSQLDSQLHSPMYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHWLG 112
Cdd:cd15162     5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNM 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 113 CTECVVLAAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFgnsLVQVILTVQlpfcgRQVLnnffcEVPAMIKLS 192
Cdd:cd15162    85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLAL---LVTLPLYLV-----KQTI-----FLPALDITT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 193 CADTTANDATLAVLVAFFV-------LVPLALILLSYGFIARAVMRIQSSRGRHKAFGTCSSHLLVVSLF--------YL 257
Cdd:cd15162   152 CHDVLPEQLLVGDWFYYFLslaivgfLIPFILTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFiicfapsnLL 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195679774 258 PAIYMYLQPPSSYSQEQGKF-ISLFYSIITPTLNPFIYTLRNKD 300
Cdd:cd15162   232 LLAHYSLISSSGTGHLYFAYlLALCLSTLNSCIDPFIYYFVSKE 275
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 121-236 8.65e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 37.31  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 121 AMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILT-----VQLPFCGRQVLNNFFC----EVPAMIKL 191
Cdd:cd15134    94 AFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTrivylEYPPTSGEALEESAFCamlnEIPPITPV 173

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195679774 192 SCADTTandatlavlvaFFVLVPLALILLSYGFIAravMRIQSSR 236
Cdd:cd15134   174 FQLSTF-----------LFFIIPMIAIIVLYVLIG---LQLRRST 204
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
 31-305 9.93e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 37.04  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774  31 VFAVLLVsyILAMLGNISIILVSQLDSQLHSpmYIFLSHLSFLDLCYTTTTVPQMLFNMGSSQKTISYGGCTVQYAIFHW 110
Cdd:cd15220     4 FCMVLLD--LTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 111 LGCTECVVL--AAMALDRYVAICEPLRYAIIMHRPLCQQLVAMAWLSGFGNSLVQVILTVqlPFCGRQVLNNFFCEVpam 188
Cdd:cd15220    80 VCLVSASILtiSAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWP--SYGGPAPIAARHCSL--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195679774 189 iklsCADTTANDATLAVLVA-FFVLVPLALILLSYGFIARAVmriqssrGRHKAFGTCsshLLVVSLF---YLPAIYMYL 264
Cdd:cd15220   155 ----HWSHSGHRGVFVVLFAlVCFLLPLLLILVVYCGVFKVF-------GGGKAALTL---AAIVGQFlccWLPYFAFHL 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1195679774 265 QP-----PSSYSQEQGKFISLFYSiiTPTLNPFIYTLRNKDVKGAL 305
Cdd:cd15220   221 YSalaasPVSGGEAEEVVTWLAYS--CFAVNPFFYGLLNRQIREEL 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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