NCBI Conserved Domain Search

Conserved domains on [gi|1195675114|ref|XP_021030925|]

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olfactory receptor 6C74-like [Mus caroli]

Protein Classification

olfactory receptor( domain architecture ID 11610373)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-291

5.71e-132

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 375.67 E-value: 5.71e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGpNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-291

5.71e-132

Pssm-ID: 320578 Cd Length: 270 Bit Score: 375.67 E-value: 5.71e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGpNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-302

1.27e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 134.94 E-value: 1.27e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  33 YVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQFFL 112
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 113 LAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILKLSCNDTRf 191
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLSCADIK- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 192 mqlLNFIFAIFILLMTLA----LVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERIS- 266
Cdd:pfam13853 164 ---VNNIYGLFVVTSTFGidslLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPp 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 267 -LNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:pfam13853 241 lLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-291

5.71e-132

Pssm-ID: 320578 Cd Length: 270 Bit Score: 375.67 E-value: 5.71e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGpNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

23-291

9.23e-107

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 311.73 E-value: 9.23e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSnVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

23-298

1.43e-101

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 298.99 E-value: 1.43e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIavfaicpGVMVSL-------SLEFCDT-IIEHF 174
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLS-------GILVSLgqttlifSLPFCGSnEINHF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 175 FCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIF 254
Cdd:cd15225   154 FCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASF 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195675114 255 MYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15225   234 TYLRPKSSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

23-291

2.30e-99

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 293.24 E-value: 2.30e-99

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGpNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

23-291

1.33e-90

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 270.92 E-value: 1.33e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15230     1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15230    81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSnVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15230   161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15230   241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-295

7.48e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 269.58 E-value: 7.48e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  10 FILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKT 89
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  90 ISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT 169
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 170 -IIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSIS 248
Cdd:cd15408   161 nVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195675114 249 YGSCIFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVK 295
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-298

4.98e-87

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 262.16 E-value: 4.98e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  22 QIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFA 101
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSP 180
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCgSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 261 AEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15235   241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

27-291

2.23e-86

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 260.24 E-value: 2.23e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  27 LFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFG 106
Cdd:cd15918     6 LFLGM-YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 107 IAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILKLS 185
Cdd:cd15918    85 DLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCaSNEIPHFFCDLNPLLKLS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 186 CNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERI 265
Cdd:cd15918   165 CSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSA 244

                         250       260
                  ....*....|....*....|....*.
gi 1195675114 266 SLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15918   245 SKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

24-298

1.05e-84

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 255.94 E-value: 1.05e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPIL 182
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSrEIHHFFCEVPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15421   242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

10-302

2.00e-84

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 256.14 E-value: 2.00e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  10 FILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKT 89
Cdd:cd15943     2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  90 ISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT 169
Cdd:cd15943    82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 170 -IIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSIS 248
Cdd:cd15943   162 nVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195675114 249 YGSCIFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:cd15943   242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-302

6.39e-83

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 252.19 E-value: 6.39e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  10 FILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKT 89
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  90 ISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVfaICPGVMVS--LSLEFC 167
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGI--VCSLIHTCglLRLSFC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 168 D-TIIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVS 246
Cdd:cd15410   159 GsNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAIT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195675114 247 ISYGSCIFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:cd15410   239 IFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

23-291

7.34e-83

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 251.05 E-value: 7.34e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15224     1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15224    81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCgPNVINHFFCDISPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15224   161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15224   241 ISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

23-291

1.78e-82

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 250.27 E-value: 1.78e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15237     1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCgPNHINHFFCEAPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15237   241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

23-291

2.45e-82

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 249.83 E-value: 2.45e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15431     1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDTIIEHFFCDYSPIL 182
Cdd:cd15431    81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMPLHFCGPNVINHFFCEVQALL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15431   161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                         250       260
                  ....*....|....*....|....*....
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15431   241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

23-298

5.32e-82

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 249.05 E-value: 5.32e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15229     1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15229    81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPnEINHFSCELPSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15229   161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15229   241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

23-298

6.24e-82

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 249.10 E-value: 6.24e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15231     1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15231    81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSnQISHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15231   161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15231   241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

23-299

6.98e-81

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 246.40 E-value: 6.98e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLL----FVSCCLIAVFAICPGvmvsLSLEFCDT-IIEHFFCD 177
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLvagaYLGGFLNSLIQTVSM----FQLSFCGPnVIDHFFCD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 178 YSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYI 257
Cdd:cd15417   157 IPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYL 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195675114 258 KPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15417   237 RPSSSHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

23-299

8.75e-81

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 246.07 E-value: 8.75e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCgSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15419   241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

23-299

1.90e-79

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 242.61 E-value: 1.90e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSnVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

23-291

2.71e-78

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 239.45 E-value: 2.71e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCgHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

25-291

6.90e-78

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 238.51 E-value: 6.90e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15227     4 FVLFLLI-YLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVF--AICPGVMVSLSLeFCDTIIEHFFCDYSPIL 182
Cdd:cd15227    83 FAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLygALHTANTFSLPF-CGSNVIHQFFCDIPQLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15227   162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                         250       260
                  ....*....|....*....|....*....
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15227   242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-302

1.73e-77

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 238.04 E-value: 1.73e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  14 GLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVE 93
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  94 ACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIE 172
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCgDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 173 HFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSC 252
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195675114 253 IFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:cd15406   241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-299

2.00e-76

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 235.41 E-value: 2.00e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  10 FILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKT 89
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  90 ISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-D 168
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCgS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 169 TIIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSIS 248
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195675114 249 YGSCIFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALK 291

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

24-298

4.83e-76

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 233.81 E-value: 4.83e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15434     2 ILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVC-TLLFVS--CCLIAVFAICPgvmVSLSLEFC-DTIIEHFFCDYS 179
Cdd:cd15434    82 GLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCwKLVAMSwlIGFGNSLVLSP---LTLSLPRCgHHRVDHFFCEMP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 180 PILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKP 259
Cdd:cd15434   159 ALIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQP 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195675114 260 SAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15434   239 KNSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

23-299

5.97e-76

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 233.75 E-value: 5.97e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15413     1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15413    81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSnVINHFYCDDLPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15413   161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15413   241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALK 278

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

23-299

1.01e-75

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 233.41 E-value: 1.01e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLL----FVSCCLIAVfaICPGVMVSLSleFCDT-IIEHFFCD 177
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLvaasYLGGCLNAL--VFTTCVFSLS--FCGPnEINHFFCD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 178 YSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYI 257
Cdd:cd15416   157 FPPLLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYV 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195675114 258 KPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15416   237 MPNSSYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

23-291

2.97e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 231.88 E-value: 2.97e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15914     1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15914    81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGpNQIQHIFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15914   161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15914   241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-302

3.21e-75

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 232.37 E-value: 3.21e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  10 FILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKT 89
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  90 ISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT 169
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 170 -IIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSIS 248
Cdd:cd15944   161 nIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195675114 249 YGSCIFMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

22-298

1.61e-74

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 230.16 E-value: 1.61e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  22 QIVIFLFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFA 101
Cdd:cd15234     1 PLLFGLFLSM-YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSP 180
Cdd:cd15234    80 FLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCtDVEIPHFFCELAQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTrfmqllnFIFAIFILLMTLAL-------VMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCI 253
Cdd:cd15234   160 VLKLACSDT-------LINNILIYLATVIFggiplsgIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGL 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195675114 254 FMYIKPSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15234   233 GVYISSAVTHSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

23-299

2.62e-74

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 229.60 E-value: 2.62e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15409     1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15409    81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSnEINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15409   161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15409   241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

23-298

5.26e-74

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 228.75 E-value: 5.26e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15420     1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15420    81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGpNEVNHFFCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15420   161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15420   241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-291

6.21e-74

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 228.30 E-value: 6.21e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPnIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

25-298

6.49e-74

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 228.44 E-value: 6.49e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILK 183
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCgHNTINHFSCELLAVVR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEE 263
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195675114 264 RISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15429   243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

23-291

2.64e-71

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 221.81 E-value: 2.64e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15913     1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIA-VFAICPGVMVSlSLEFC-DTIIEHFFCDYSP 180
Cdd:cd15913    81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGfLWFLIPVVLIS-QLPFCgPNIIDHFLCDPGP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15913   160 LLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPG 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195675114 261 AEERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15913   240 SGNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-291

2.66e-71

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 221.48 E-value: 2.66e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15430    81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCgNNVINHFTCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15430   161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15430   241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

23-299

5.07e-71

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 221.14 E-value: 5.07e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSnVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFK 278

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

23-300

9.54e-71

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 220.35 E-value: 9.54e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSnVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKD 300
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-291

2.96e-70

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 218.62 E-value: 2.96e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15939     2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPIL 182
Cdd:cd15939    82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPnVIDHFFCDLFPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTiLRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15939   162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*....
gi 1195675114 263 erISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15939   241 --FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

23-298

1.31e-69

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 217.73 E-value: 1.31e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15428     1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15428    81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGgHNKINHFLCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15428   161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15428   241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

23-295

1.78e-69

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 217.30 E-value: 1.78e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15424     1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15424    81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGpNHINHFFCELPVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15424   161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVK 295
Cdd:cd15424   241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVH 274

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

23-304

1.30e-68

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 215.37 E-value: 1.30e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVF-AICPGVMVSLSLEFCDTIIEHFFCDYSPI 181
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLnTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDIIKK 304
Cdd:cd15414   241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

23-291

1.50e-67

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 212.06 E-value: 1.50e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15226    81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGpNVVDSFFCDLPLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTIlRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15226   161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 eeRISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15226   240 --TFPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

23-291

2.30e-67

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 211.40 E-value: 2.30e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15915     1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15915    81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPnKINHFFCDIKPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFP-SAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15915   161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195675114 261 AEERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15915   241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

23-299

6.83e-67

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 210.73 E-value: 6.83e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15415     1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15415    81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGpNVINHYFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15415   161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15415   241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

7.11e-67

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 210.79 E-value: 7.11e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  22 QIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFA 101
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSP 180
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCgDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195675114 261 AEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESLK 299
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALK 279

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-298

8.94e-66

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 207.72 E-value: 8.94e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15233     2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVF-AICPGVMVSLsLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15233    82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTnALTHTVAMST-LKFCGpNVINHFFCDLPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15233   161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15233   241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

23-298

1.15e-64

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 205.02 E-value: 1.15e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPI 181
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCgRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-298

1.22e-64

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 205.00 E-value: 1.22e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLsitGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15236     5 ALFLAMYLTTVL---GNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPIL 182
Cdd:cd15236    82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCaDNVIPHFFCDLVALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15236   162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15236   242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

23-298

5.07e-64

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 203.06 E-value: 5.07e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMD-KTISVEACFTQLFA 101
Cdd:cd15916     1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDTI-IEHFFCDYSP 180
Cdd:cd15916    81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNrIDYFFCDIPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15916   161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 261 AEEriSLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15916   241 SKE--ALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

23-291

5.37e-63

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 200.36 E-value: 5.37e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15940     1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15940    81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGpNEIDSFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFpSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15940   161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EerISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15940   240 S--FSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-298

5.69e-63

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 200.72 E-value: 5.69e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  26 FLFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIF 105
Cdd:cd15405     5 FLFLGI-YVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 106 GIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILKL 184
Cdd:cd15405    84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSnIINHYMCDILPLLQL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 185 SCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEER 264
Cdd:cd15405   164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195675114 265 ISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15405   244 VNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

23-291

2.28e-62

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 198.86 E-value: 2.28e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15946     1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15946    81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGpNEINHYFCEVPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15946   161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 EERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15946   241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

23-298

2.05e-60

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 193.80 E-value: 2.05e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15228     2 ILFVLFLAF-YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15228    81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSnVVDYFFCDIFPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSA 261
Cdd:cd15228   161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 262 EEriSLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15228   241 SP--VLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

24-298

4.72e-60

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 193.08 E-value: 4.72e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15433     2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPIL 182
Cdd:cd15433    82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGhRLLDHFFCEMPVFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAE 262
Cdd:cd15433   162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15433   242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

24-291

3.03e-59

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 190.62 E-value: 3.03e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15936     2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPIL 182
Cdd:cd15936    82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGpNVLDNFYCDVPQVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYgKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSae 262
Cdd:cd15936   162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISY-TVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPF-- 238

                         250       260
                  ....*....|....*....|....*....
gi 1195675114 263 ERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15936   239 QTFPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-298

7.00e-58

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 187.26 E-value: 7.00e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15942     3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILK 183
Cdd:cd15942    83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGqKNEVDYIFCDIPAMLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEE 263
Cdd:cd15942   163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195675114 264 riSLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15942   243 --PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

25-298

3.14e-54

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 178.12 E-value: 3.14e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFIT-YVLSITGNLTIILLTLLDSHLKT-PMYYFLQKFSFLEISLTSTCIPRFLVSIVTMD-KTISVEACFTQLFA 101
Cdd:cd15941     2 LFFLLFLLiYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDTI-IEHFFCDYSP 180
Cdd:cd15941    82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCqIAYFFCDIPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15941   162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 261 AEEriSLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15941   242 SSQ--AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

25-291

1.52e-53

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 175.83 E-value: 1.52e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15938     3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPILK 183
Cdd:cd15938    83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGpNQVNNFFCDVPPVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTIlrfPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEe 263
Cdd:cd15938   163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST- 238

                         250       260
                  ....*....|....*....|....*...
gi 1195675114 264 rISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15938   239 -FPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

25-298

3.17e-53

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 175.56 E-value: 3.17e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15223     3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILK 183
Cdd:cd15223    83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSnVIEHCYCDHMALVS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEE 263
Cdd:cd15223   163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGK 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 264 RIS--LNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd15223   243 TIPpdVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

23-291

6.11e-52

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 171.87 E-value: 6.11e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHL-KTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFA 101
Cdd:cd15935     1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSP 180
Cdd:cd15935    81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGpNELDNFYCDVPQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTiLRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS 260
Cdd:cd15935   161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195675114 261 AeeRISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15935   240 S--SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

23-291

4.93e-50

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 166.84 E-value: 4.93e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15937     1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPI 181
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGpNVLDNFFCDITQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTiLRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSa 261
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPF- 238

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195675114 262 eERISLNKGIAILTLALAPVLNPFIYTLRN 291
Cdd:cd15937   239 -RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

25-294

7.39e-49

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 164.00 E-value: 7.39e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd15917     3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILK 183
Cdd:cd15917    83 FTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSnVISHSYCEHMAVVK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEE 263
Cdd:cd15917   163 LACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGH 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195675114 264 RISLNKGI--AILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15917   243 HVPPHVHIllANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

26-294

1.17e-43

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 150.64 E-value: 1.17e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  26 FLFLFItYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIF 105
Cdd:cd15950     5 IPFCSM-YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 106 GIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILKL 184
Cdd:cd15950    84 TAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCgSRVVPHSYCEHMAVVKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 185 SCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIF-MYIKPSAEE 263
Cdd:cd15950   164 ACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQG 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195675114 264 -----RISLnkgiAILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15950   244 vpphtQVLL----ADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

30-294

6.00e-43

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 148.68 E-value: 6.00e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  30 FITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQ 109
Cdd:cd15952     8 CAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGME 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 110 FFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCD-TIIEHFFCDYSPILKLSCND 188
Cdd:cd15952    88 SAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGhNIIPHTYCEHMGIAKLACAS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 189 TRfMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERISLN 268
Cdd:cd15952   168 IR-INIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRY 246

                         250       260
                  ....*....|....*....|....*...
gi 1195675114 269 KGI--AILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15952   247 IHIllANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

30-294

9.86e-42

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 145.51 E-value: 9.86e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  30 FITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLF-AAFIFGIA 108
Cdd:cd15221     8 CSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFfVHFVFVTE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 109 QFFLLAvMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILKLSCN 187
Cdd:cd15221    88 SAILLA-MAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHnVIPHTYCEHMGIARLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 188 DTRfmqlLNFIFAIFILLMTLALVMF----SYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEE 263
Cdd:cd15221   167 DIT----VNIWYGLTVALLTVGLDVVliavSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGR 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195675114 264 RISLNKGI--AILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15221   243 HIPRHVHIllANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-294

5.31e-41

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 143.80 E-value: 5.31e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLvSIVTMD-KTISVEACFTQLFAAF 103
Cdd:cd15222     3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVL-GIFWFNaREISFDACLAQMFFIH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPIL 182
Cdd:cd15222    82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFChSNVLSHSYCLHQDVM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYgscIFMyIKPSAE 262
Cdd:cd15222   162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFY---VPM-IGLSMV 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195675114 263 ERISLNKG------IAILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15222   238 HRFGKHASplvhvlMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-294

7.72e-41

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 143.17 E-value: 7.72e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  29 LFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIA 108
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 109 QFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILKLSCN 187
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANrIIPHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 188 DTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKpsaeERISL 267
Cdd:cd15953   167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLT----HRFGQ 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195675114 268 NKG------IAILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15953   243 GIAphihiiLANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

21-294

9.83e-40

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 140.38 E-value: 9.83e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  21 WQIVIFLFLfitYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLF 100
Cdd:cd15956     2 WLSLPFCFI---YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 101 AAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYS 179
Cdd:cd15956    79 LVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCAShTIAHTYCEHM 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 180 PILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIK- 258
Cdd:cd15956   159 AVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMh 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195675114 259 ------PSAEERISLNkgiaiLTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15956   239 rfghsvPSAAHVLLSN-----LYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

33-295

2.55e-39

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 139.27 E-value: 2.55e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  33 YVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQFFL 112
Cdd:cd15948    12 FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 113 LAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILKLSCNDTRF 191
Cdd:cd15948    92 LLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRShVIAHCYCEHMAVVKLACGDTRF 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 192 MQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERISLNKGI 271
Cdd:cd15948   172 NNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAPHVHI 251

                         250       260
                  ....*....|....*....|....*.
gi 1195675114 272 --AILTLALAPVLNPFIYTLRNKQVK 295
Cdd:cd15948   252 llANFYLLFPPMMNPIVYGVKTKQIR 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-302

1.27e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 134.94 E-value: 1.27e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  33 YVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQFFL 112
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 113 LAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC-DTIIEHFFCDYSPILKLSCNDTRf 191
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLSCADIK- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 192 mqlLNFIFAIFILLMTLA----LVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERIS- 266
Cdd:pfam13853 164 ---VNNIYGLFVVTSTFGidslLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPp 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195675114 267 -LNKGIAILTLALAPVLNPFIYTLRNKQVKESLKDII 302
Cdd:pfam13853 241 lLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-294

1.69e-36

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 131.70 E-value: 1.69e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  31 ITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQF 110
Cdd:cd15951     9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 111 FLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPILKLSCNDT 189
Cdd:cd15951    89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTnIIPHTYCEHMAVVKLACADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 190 RFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERISLNK 269
Cdd:cd15951   169 RVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPHV 248

                         250       260
                  ....*....|....*....|....*..
gi 1195675114 270 GI--AILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15951   249 HIliANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

23-294

2.61e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 123.39 E-value: 2.61e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15954     1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDT-IIEHFFCDYSPI 181
Cdd:cd15954    81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGnFIPHTYCDHMSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPS- 260
Cdd:cd15954   161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRf 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195675114 261 AEERISLNKGIAI--LTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15954   241 GGHHITPHIHIIManLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-295

4.12e-31

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 117.96 E-value: 4.12e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114   8 TTFILLGLTEDPKWQIVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMD 87
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  88 KTISVEACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC 167
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 168 DT-IIEHFFCDYSPILKLSCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVS 246
Cdd:cd15949   162 RTnIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195675114 247 ISYGSCIFMYIKPSAEERISLNKGI--AILTLALAPVLNPFIYTLRNKQVK 295
Cdd:cd15949   242 AFYVPIAVSSLIHRFGQNVPPPTHIllANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

30-294

1.18e-27

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 108.32 E-value: 1.18e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  30 FITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFIFGIAQ 109
Cdd:cd15955     8 CIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 110 FFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAI--CPGVMVSLSLEFCDTIIEHFFCDYSPILKLSCN 187
Cdd:cd15955    88 SGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIipCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAAD 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 188 DTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERISL 267
Cdd:cd15955   168 DVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAP 247

                         250       260
                  ....*....|....*....|....*....
gi 1195675114 268 NKGI--AILTLALAPVLNPFIYTLRNKQV 294
Cdd:cd15955   248 YVHIllSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-287

2.20e-26

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 104.69 E-value: 2.20e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  39 GNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVT-MDKTISVEACFTQLFAAFIFGIAQFFLLAVMS 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 118 YDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDTiiEHFFCDYSPILKLSCNdtrfmQLLNF 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG--NVTVCFIDFPEDLSKP-----VSYTL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 198 IFAIFILLMTLALVMFSYGKIISTIL-------RFPSAQQKKKAFSTCSSHMIVVSISYGSCIFMYIKPSAEERISLNKG 270
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRksaskqkSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233

                         250       260
                  ....*....|....*....|...
gi 1195675114 271 I---AILTLALA---PVLNPFIY 287
Cdd:pfam00001 234 LdkaLSVTLWLAyvnSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

25-291

4.10e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 79.64 E-value: 4.10e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  25 IFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAFI 104
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFcdtiiehffcDYSPILKL 184
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY----------GGYCCCCL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 185 SCNDTRFMQLLNFIFAIFILLMTLALVMFSYGKIISTILR--------------FPSAQQKKKAFSTCSSHMIVVSISYG 250
Cdd:cd00637   151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCWL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195675114 251 -SCIFMYIKPSAEERISLNKGIAILTLALA---PVLNPFIYTLRN 291
Cdd:cd00637   231 pYFILLLLDVFGPDPSPLPRILYFLALLLAylnSAINPIIYAFFN 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

23-298

2.01e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 57.22 E-value: 2.01e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSlslEFcdtIIEHFFCDYSPIL 182
Cdd:cd14969    81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWS---SY---VPEGGGTSCSVDW 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 183 KLscNDTRFMQLLNFIFaIFILLMTLALVMFSYGKIISTILRFPSAQQKKKAFSTCSSH---------MIVVSIS----- 248
Cdd:cd14969   155 YS--KDPNSLSYIVSLF-VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakMVLVMIVaflia 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195675114 249 ---YGSCIFMYikpSAEERISLNKGIAILTLALA---PVLNPFIYTLRNKQVKESL 298
Cdd:cd14969   232 wtpYAVVSLYV---SFGGESTIPPLLATIPALFAkssTIYNPIIYVFMNKQFRRAL 284

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-298

4.21e-09

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 56.03 E-value: 4.21e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCtllfvsCCLIAVFAICPGVMVSLSLefcdtIIEHFFCDYSPILK 183
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRA------LIMIAAVWVYSLLISLPPL-----VGWRDETQPSVVDC 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 184 LSCndtrFMQLLNFIFAIFILLMTL-ALVM-FSYGKIISTilrfpsAQQKKKAFSTcsshMIVVSISYGSC------IFM 255
Cdd:cd14967   150 ECE----FTPNKIYVLVSSVISFFIpLLIMiVLYARIFRV------ARRELKAAKT----LAIIVGAFLLCwlpffiIYL 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195675114 256 YIKPSAEERISLNKGIAILTLALA-PVLNPFIYTLRNKQVKESL 298
Cdd:cd14967   216 VSAFCPPDCVPPILYAVFFWLGYLnSALNPIIYALFNRDFRRAF 259

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

23-293

1.87e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 48.43 E-value: 1.87e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15074     1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSlslefcdtiiehffcDYSP-I 181
Cdd:cd15074    81 FLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWG---------------SYGPeP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 182 LKLSC--------NDTRFMQLLNFIFaIFILLMTLALVMFSYGKIISTI--LRFPSAQQKKKAFSTCSSHMIVVSISYGS 251
Cdd:cd15074   146 FGTSCsidwtgasASVGGMSYIISIF-IFCYLLPVLIIVFSYVKIIRKVksSRKRVAGFDSRSKRQHKIERKVTKVAVLI 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195675114 252 CIFMYIKPSAEERISL------NKGIAILTLALAPVL-------NPFIYTLRNKQ 293
Cdd:cd15074   225 CAGFLIAWTPYAVVSMwsafgsPDSVPILASILPALFaksscmyNPIIYLLFSSK 279

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

23-224

2.24e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 48.36 E-value: 2.24e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACftqLFAA 102
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLC---KAVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQF---FLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSlslefcdTIIEHFFCDYS 179
Cdd:cd14993    78 YLQGVSVSasvLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVY-------ELEEIISSEPG 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1195675114 180 PILKLSCNDTRFMQLLNFIFAIFILLMT----LALVMFSYGKIISTILR 224
Cdd:cd14993   151 TITIYICTEDWPSPELRKAYNVALFVVLyvlpLLIISVAYSLIGRRLWR 199

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

30-134

5.69e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 44.15 E-value: 5.69e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  30 FITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPrFLVSIvTMDKTISVEACFtqLFAAFIFGIAQ 109
Cdd:cd15069     8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP-FAITI-SLGFCTDFHSCL--FLACFVLVLTQ 83

                          90       100
                  ....*....|....*....|....*...
gi 1195675114 110 ---FFLLAVmSYDRYVAICRPLHYTTIM 134
Cdd:cd15069    84 ssiFSLLAV-AVDRYLAIKVPLRYKSLV 110

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-297

7.17e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 43.69 E-value: 7.17e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEIsLTSTCIPRFLVSIVTMDK-TISVEACFTQLFAA 102
Cdd:cd15085     2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDL-MMALCGTTIVTVTNYEGYfYLGDAFCIFQGFAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICP----------GVMVSLSLEFcdtiIE 172
Cdd:cd15085    81 NYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPlfgwssygpeGVQTSCSIGW----EE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 173 HFFCDYSPILklscndtrfmqllnfIFAIFILLMTLALVMFSYGKIISTI--LRFPSAQQKKKAFSTCSSHMI----VVS 246
Cdd:cd15085   157 RSWSNYSYLI---------------LYFLMCFVIPVAIIGFSYGNVLRSLhkLNKKIEQQGGKNCPEEEERAVimvlAMV 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195675114 247 ISYGSCIFMYIKPSA----EERISLNKGIAILTLALA---PVLNPFIYTLRNKQVKES 297
Cdd:cd15085   222 IAFLICWLPYTVFALivvvNPELSISPLAATMPTYFAktsPVYNPIIYIFLNKQFRES 279

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

24-161

8.31e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 43.50 E-value: 8.31e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMyyflqkfSFLEISLTSTcipRFLVSIVTMDKTI--SVEAC--FTQL 99
Cdd:cd15312     2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPT-------NFLILSLAIT---DFLLGFLVMPYSMvrSVESCwyFGDL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1195675114 100 FAAF------IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTL-LFVSCCLIAVFAIcpGVMVS 161
Cdd:cd15312    72 FCKIhssldmMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVfLVISWSVPCLFAF--GVVFS 138

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

95-154

9.14e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 43.31 E-value: 9.14e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195675114  95 CFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHY-TTIMNNRVCTLLFVS--CCLIAVFAI 154
Cdd:cd15055    73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYpTKITIRRVKICICLCwfVSALYSSVL 135

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

26-218

1.68e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 42.63 E-value: 1.68e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  26 FLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDK-TISVEACFTQLFAAFI 104
Cdd:cd15217     4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 105 FGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFC----DTIIEHFFcdysp 180
Cdd:cd15217    84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIreedQCIFEHRY----- 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1195675114 181 ilkLSCNDTR-FMQLLN-FIFAIFILLMTLALVMFSYGKI 218
Cdd:cd15217   159 ---FKANDTLgFMLMLAvLIVATHIVYGKLLLFEYRHRKM 195

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

23-176

3.13e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 41.84 E-value: 3.13e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYflqkfsfLEISLTSTcipRFLVSIVTMDKTI--SVEAC--FTQ 98
Cdd:cd15314     1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNY-------LILSLAVA---DLLVGGLVMPPSMvrSVETCwyFGD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  99 LFAAF------IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRV-CTLLFVSCCLIAVFAICpgvMVSLSLEFCDTII 171
Cdd:cd15314    71 LFCKIhssfdiTLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVvLVMILISWSVSALVGFG---IIFLELNIKGIYY 147


                  ....*
gi 1195675114 172 EHFFC 176
Cdd:cd15314   148 NHVAC 152

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

24-278

4.35e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 41.41 E-value: 4.35e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITyvlSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCiPRFLVSIVTMDKTISVEACftQLFAAF 103
Cdd:cd15079     5 FIYIFLGIV---SLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC--QIYAFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 104 --IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICP-----------GVMVSLSLefcdti 170
Cdd:cd15079    79 gsLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWALLPllfgwgryvpeGFLTSCSF------ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 171 iehffcDYspilkLSCN-DTRFmqllnFIFAIFIL--LMTLALVMFSYGKIISTILRFPSA--QQKKKafstcsshMIVV 245
Cdd:cd15079   153 ------DY-----LTRDwNTRS-----FVATIFVFayVIPLIIIIYCYSFIVKAVFAHEKAlrEQAKK--------MNVV 208

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195675114 246 SISYGSCIfmyIKPSAEERISlnkGIAILTLAL 278
Cdd:cd15079   209 SLRSNADA---NKQSAEIRIA---KVALTNVFL 235

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

29-128

4.79e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 41.32 E-value: 4.79e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  29 LFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLE--ISLTSTCIprflvSIVTMDKT---ISVEACFTQLFAAF 103
Cdd:cd15082    20 MFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADflVSLTGGTI-----SFLTNARGyffLGVWACVLEGFAVT 94

                          90       100
                  ....*....|....*....|....*
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPL 128
Cdd:cd15082    95 FFGIVALWSLAVLAFERFFVICRPL 119

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

21-132

6.65e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 40.70 E-value: 6.65e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  21 WQIVIFLFLF-ITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQL 99
Cdd:cd15299     1 WQVVLIAFLTgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195675114 100 FAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTT 132
Cdd:cd15299    81 SIDYVASNASVMNLLVISFDRYFSITRPLTYRA 113

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

36-142

9.06e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 40.52 E-value: 9.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  36 SITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEA-CFTQLFAAFIFGIAQFFLLA 114
Cdd:cd15005    14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALsCKVIAFLAVLFCFHSAFTLF 93

                          90       100
                  ....*....|....*....|....*...
gi 1195675114 115 VMSYDRYVAICRPLHYTTIMNNRVCTLL 142
Cdd:cd15005    94 CIAVTRYMAIAHHRFYAKRMTFWTCLAV 121

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

110-298

9.38e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 40.33 E-value: 9.38e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 110 FFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLfvsCCLIAVFAICPGVMVSLSLEFCDTIIEHFFCdyspiLKLSCNDT 189
Cdd:cd14982    88 ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGV---CAGVWILVLVASVPLLLLRSTIAKENNSTTC-----FEFLSEWL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 190 RFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQ----KKKAFSTCSSHMIVVSIS---YGSCIFMYIK---- 258
Cdd:cd14982   160 ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCflpYHVTRILYLLvrls 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195675114 259 ----PSAEERISLNKGIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd14982   240 fiadCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

34-298

1.06e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 39.93 E-value: 1.06e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  34 VLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPrfLVSIVTMDKTISVEAC-FTQLFAAFIFGIAQFFL 112
Cdd:cd14968    12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGClFMACLVLVLTQSSIFSL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 113 LAVmSYDRYVAICRPLHYTTIMNNRVcTLLFVSCCLIAVFAIcpGVMVSLSLEFCDTIIEHFFCDYSPILKLSCNDTRFM 192
Cdd:cd14968    90 LAI-AIDRYLAIKIPLRYKSLVTGRR-AWGAIAVCWVLSFLV--GLTPMFGWNNGAPLESGCGEGGIQCLFEEVIPMDYM 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 193 qlLNFIFAIFILLmTLALVMFSYGKIISTILRfpsaQQKKKAFSTCSSH--------------MIVVSISYGSC------ 252
Cdd:cd14968   166 --VYFNFFACVLV-PLLIMLVIYLRIFRVIRK----QLRQIESLLRSRRsrstlqkevkaaksLAIILFLFALCwlplhi 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1195675114 253 --IFMYIKPSAEERISLNKgIAILTLALAPVLNPFIYTLRNKQVKESL 298
Cdd:cd14968   239 inCITLFCPECKVPKILTY-IAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

23-145

1.62e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 39.39 E-value: 1.62e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15062     1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVS 145
Cdd:cd15062    81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLI 123

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

23-211

1.72e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 39.39 E-value: 1.72e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICR-PLHYTtiMNNRVCTLLFVSCCLIAVFAICPGVMVSLSLEFCDTIIEHFFCDYSPI 181
Cdd:cd15056    81 VLLTTASIMHLCCIALDRYYAICCqPLVYK--MTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNCASGSTS 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1195675114 182 LKLSCNDTRFMQLLNFIFAIFILLMTLALV 211
Cdd:cd15056   159 CVFMVNKPFAIICSTVAFYIPALLMVLAYY 188

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

23-130

1.81e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 39.42 E-value: 1.81e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15301     1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80

                          90       100
                  ....*....|....*....|....*...
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHY 130
Cdd:cd15301    81 YLASNASVLNLLIISFDRYFSVTRPLTY 108

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

53-298

2.04e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 39.08 E-value: 2.04e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  53 LKTPMYYFLQKFSFLEISLT----STCIPRFLVSIVTMDKTisveACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPL 128
Cdd:cd15084    41 LRSPLNYILVNLAVADLLVTlfgsSVSFSNNIVGFFVFGKT----MCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPM 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 129 HYTTIMNNRvctllfvsccliAVFaicpGVMVSLSLEFCDTIIEHF-FCDYSPI-LKLSCNDTRFMQLLN---FIFAIFI 203
Cdd:cd15084   117 GDFRFQQRH------------AVS----GCAFTWGWSLLWTSPPLFgWSSYVPEgLRTSCGPNWYTGGTNnnsYILALFV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 204 --LLMTLALVMFSYGKIISTiLRFPSAQQK-----KKAFSTCSSHMIVVSISYGSCIFMYikPSAEERISLNKGIAIL-T 275
Cdd:cd15084   181 tcFALPLSTIIFSYSNLLLT-LRAVAAQQKesettQRAEKEVTRMVIAMVMAFLICWLPY--ATFAMVVATNKDVVIQpT 257

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195675114 276 LALAP--------VLNPFIYTLRNKQVKESL 298
Cdd:cd15084   258 LASLPsyfsktatVYNPIIYVFMNKQFRSCL 288

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

96-154

2.85e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 38.75 E-value: 2.85e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195675114  96 FTQLFAAFifgiAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAI 154
Cdd:cd15196    78 YLQVVGMY----ASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSI 132

7tmA_SWS2_opsin

cd15077

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...

94-295

2.90e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320205 [Multi-domain] Cd Length: 280 Bit Score: 38.66 E-value: 2.90e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  94 ACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNnrvcTLLFVSCCLIAVFAICPGVMVSLSleFCDTIIEH 173
Cdd:cd15077    72 ACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRG----THAIIGCIATWVFGLAASLPPLFG--WSRYIPEG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 174 FFCDYSPILKLSCNDTRFMQLLNFIFaIFILLMTLALVMFSYGKIISTiLRFPSAQQK-----KKAFSTCSSHMIVVSIS 248
Cdd:cd15077   146 LQCSCGPDWYTTNNKWNNESYVMFLF-CFCFGVPLSIIVFSYGRLLLT-LRAVAKQQEqsastQKAEREVTKMVVVMVLG 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195675114 249 YGSCIFMYikPSAEERISLNKGIAI-LTLALAP--------VLNPFIYTLRNKQVK 295
Cdd:cd15077   224 FLVCWLPY--ASFALWVVTNRGEPFdLRLASIPsvfskastVYNPVIYVFMNKQFR 277

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

23-155

3.50e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 38.43 E-value: 3.50e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEA-CFTQLFA 101
Cdd:cd14997     1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFmCKLVPFV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195675114 102 AFIFGIAQFFLLAVMSYDRYVAICRPLHyttimNNRVCTLLFVSCCLIAVFAIC 155
Cdd:cd14997    81 ELTVAHASVLTILAISFERYYAICHPLQ-----AKYVCTKRRALVIIALIWLLA 129

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

23-138

4.18e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 38.20 E-value: 4.18e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQkfsfleisltSTCIPRFLVSIVTMDKTI--SVEAC--FTQ 98
Cdd:cd15317     1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVL----------SLATADFLLGLCVMPFSMirTVETCwyFGD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195675114  99 LFAAFIFGI------AQFFLLAVMSYDRYVAICRPLHYTTIMNNRV 138
Cdd:cd15317    71 LFCKFHTGLdlllctTSIFHLCFIAIDRYYAVCDPLRYPSKITVQV 116

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

23-160

5.20e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 38.04 E-value: 5.20e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTcIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLlfVSCCL-IAVFAICPGVMV 160
Cdd:cd14970    80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKL--VSLCVwALSLVLGLPVII 136

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

24-137

5.92e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 37.77 E-value: 5.92e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  24 VIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAAF 103
Cdd:cd15336     2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1195675114 104 IFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNR 137
Cdd:cd15336    82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKK 115

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

23-137

6.03e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 37.56 E-value: 6.03e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPrfLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd15325     1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWAA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195675114 103 --FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNR 137
Cdd:cd15325    79 vdVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTER 115

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

21-303

6.69e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 37.62 E-value: 6.69e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  21 WQIVIFLFLFITyvlsITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLF 100
Cdd:cd15307     3 WALLALVLVLGT----AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWIC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 101 AAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPgVMVSLSLEFCDTIIEHFFCDYSP 180
Cdd:cd15307    79 LDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP-LSLMYSKDHASVLVNGTCQIPDP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 181 ILKLscndtrFMQLLNFIFAIFILLMTLALVMFSYGKIISTILRFPSAQQK--KKAFSTCSSHMIVVSISYGSCIFMYIK 258
Cdd:cd15307   158 VYKL------VGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKatKVLGVVFFTFVILWSPFFVLNLLPTVC 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1195675114 259 PSAEERISLNKGIAILTLALA-PVLNPFIYTLRNKQVKESLKDIIK 303
Cdd:cd15307   232 AECEERISHWVFDVVTWLGYAsSMVNPIFYTIFNKVFRQAFKKVLL 277

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-132

7.08e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.40 E-value: 7.08e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  26 FLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKfsfLEISLTSTCIPRFLVSIV---TMDKTISVEACFTQLFAA 102
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQ---LAIADLCVGLINVLTDIIwriTVEWRAGDFACKVIRYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTT 132
Cdd:cd15197    81 VVVTYASTYVLVALSIDRYDAICHPMNFSQ 110

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

108-298

7.15e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 37.39 E-value: 7.15e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 108 AQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCtLLFVSCCLIAVFAICPGVMVSLSLEFCDTIIEHffCDYSPilkLSCN 187
Cdd:cd15002    87 AKSFTIAVLAKACYMYVVNPTKQVTIKQRRIT-AVVASIWVPACLLPLPQWLFRTVKQSEGVYLCI--LCIPP---LAHE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 188 DTRFMQLLNFIFAiFILLMTLALVMfsYGKIISTILRFPSAQQ--KKKAFSTCSSHMIV-VSISYGSC------IFMYIK 258
Cdd:cd15002   161 FMSAFVKLYPLFV-FCLPLTFALFY--FWRAYGQCQRRGTKTQnlRNQIRSRKLTHMLLsVVLAFTILwlpewvAWLWLI 237

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1195675114 259 PSAEERISLNKGIAILTLALA---PVLNPFIYTLRNKQVKESL 298
Cdd:cd15002   238 HIKSSGSSPPQLFNVLAQLLAfsiSSVNPIIFLLMSEEFREGF 280

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

23-159

7.52e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 37.25 E-value: 7.52e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  23 IVIFLFLFITYVLSITGNLTIILLTLLDSHLKTPMYYFLQKFSFLEISLTSTCIPRFLVSIVTMDKTISVEACFTQLFAA 102
Cdd:cd17790     1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195675114 103 FIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLFVSCCLIAVFAICPGVM 159
Cdd:cd17790    81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAIL 137

7tmA_SWS1_opsin

cd15076

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...

94-293

7.91e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320204 [Multi-domain] Cd Length: 280 Bit Score: 37.49 E-value: 7.91e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114  94 ACFTQLFAAFIFGIAQFFLLAVMSYDRYVAICRPLHYTTIMNNRVCTLLfvscclIAVFAICPGVMVSLSLEFCDTIIEH 173
Cdd:cd15076    72 VCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNFRFGSKHALGAV------VATWIIGIGVSLPPFFGWSRYIPEG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195675114 174 FFCDYSPILKLSCNDTRFMQLLNFIFaIFILLMTLALVMFSYGKIISTiLRFPSAQQKKKAFSTCS----SHMIVVSI-S 248
Cdd:cd15076   146 LQCSCGPDWYTVGTKYRSEYYTWFLF-IFCFIVPLSIIIFSYSQLLGA-LRAVAAQQQESASTQKAerevSRMVVVMVgS 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195675114 249 YGSCIFMYIKPSAEERISLNKGIAILTLAL-------APVLNPFIYTLRNKQ 293
Cdd:cd15076   224 FCLCYVPYAALAMYMVNNRDHGLDLRLVTIpaffsksSCVYNPIIYCFMNKQ 275

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01