NCBI Conserved Domain Search

Conserved domains on [gi|1195670839|ref|XP_021028147|]

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olfactory receptor 6K3-like [Mus caroli]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11610379)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

33-293

3.50e-146

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 412.15 E-value: 3.50e-146

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15914     9 LIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15914    89 YLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 S-MILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15914   169 SlNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDR 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15914   249 AIAVVYAVLTPFFNPIIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

33-293

3.50e-146

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 412.15 E-value: 3.50e-146

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15914     9 LIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15914    89 YLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 S-MILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15914   169 SlNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDR 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15914   249 AIAVVYAVLTPFFNPIIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

34-304

2.29e-49

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 165.75 E-value: 2.29e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSCVSI-ISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLLE 270
Cdd:pfam13853 164 VNNIYGLFVVTSTFGIDSLlIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLLQ 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKMF 304
Cdd:pfam13853 244 IMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

33-293

3.50e-146

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 412.15 E-value: 3.50e-146

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15914     9 LIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15914    89 YLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 S-MILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15914   169 SlNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDR 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15914   249 AIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

33-300

1.16e-116

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 337.51 E-value: 1.16e-116

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15225     9 LIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15225    89 FLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMIlvEDVIHAISILSCV---SIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15225   169 SLN--EIAIFVASVLVILvpfLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPET 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15225   247 DKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

33-293

6.76e-114

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 330.21 E-value: 6.76e-114

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd13954     9 LIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd13954    89 FLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMIlvEDVIHAIS---ILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd13954   169 SLN--ELVIFILAgfvGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDL 246

                         250       260
                  ....*....|....*....|....
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd13954   247 DKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

33-293

4.27e-105

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 307.87 E-value: 4.27e-105

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15912     9 LTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15912    89 FLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15912   169 RLIeLLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNK 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15912   249 VVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

33-300

1.82e-101

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 298.79 E-value: 1.82e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15231     9 IIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15231    89 LLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SmiLVEDVIHAISI---LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15231   169 S--LNEVLLLVASVfigLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDK 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15231   247 DTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

33-300

2.16e-100

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 296.06 E-value: 2.16e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15235    10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15235    90 FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SmiLVEDVIH---AISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15235   170 S--LNELLIFtegAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADK 247

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15235   248 DRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

34-293

4.22e-95

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 282.47 E-value: 4.22e-95

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGN-AMIFLaVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15230    10 IYLITLVGNlGMIVL-IRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15230    89 FLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15230   169 HINeLVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDK 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15230   249 VVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

34-293

6.86e-95

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 281.68 E-value: 6.86e-95

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15911    10 IYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15911    90 LLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHA--ISILSCVSIIsLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15911   170 LVELVTFILSsiVTLPPFLLTL-TSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNK 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15911   249 VFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

35-293

7.70e-93

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 276.86 E-value: 7.70e-93

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15224    11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15224    91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 ILVEDVIHAISIL-SCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKVI 273
Cdd:cd15224   171 AELVDFILALIILlVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLV 250

                         250       260
                  ....*....|....*....|
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15224   251 SVLYTVVTPLLNPIIYCLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

33-293

2.92e-92

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 275.26 E-value: 2.92e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15918     9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15918    89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 S----MILVEDVIHAISILSCvsiISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPL 268
Cdd:cd15918   169 HlnelVILVLGGLVGLVPFLC---ILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSAS 245

                         250       260
                  ....*....|....*....|....*
gi 1195670839 269 LEKVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15918   246 KDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

34-300

3.72e-92

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 275.24 E-value: 3.72e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15229    10 IYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15229    90 LLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTF 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M----ILVEDVIHAisiLSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15229   170 AnkmvLLTSSVIFG---LGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVL 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15229   247 DRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

35-293

1.74e-91

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 273.38 E-value: 1.74e-91

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15237    11 YLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSm 194
Cdd:cd15237    91 LAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTS- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 iLVEDVIHAISI---LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15237   170 -LNEAVIFVTSVlvlLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDK 248

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15237   249 MISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

34-293

4.16e-90

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 269.71 E-value: 4.16e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15227    10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTs 193
Cdd:cd15227    90 LLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDT- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 mILVEDVIHAIS---ILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15227   169 -YLNEIGVLVLSvclGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLD 247

                         250       260
                  ....*....|....*....|...
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15227   248 LLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

9-297

1.46e-88

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 266.49 E-value: 1.46e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839   9 VTEFYFSDFPQFEdggLLLFILLLCVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSK 88
Cdd:cd15408     1 FILLGFTDQPELQ---VLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  89 EKTISFIGCLMQMYFFHSFGVTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPF 168
Cdd:cd15408    78 RKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 169 CGPNQIHQLFCDLEPVLLLACTDTSM-ILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIF 247
Cdd:cd15408   158 CGSNVINHFFCDGPPLLALSCSDTSLnEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAV 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195670839 248 VLFFGSVALMYLRFSVTFQPLLEKVIALMFAVLAPFFNPIIYSLRNKDMK 297
Cdd:cd15408   238 TLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

34-293

7.49e-88

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 264.18 E-value: 7.49e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15913    10 IYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15913    90 FLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15913   170 GTeLICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQKI 249

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15913   250 VTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

34-302

8.70e-88

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 264.12 E-value: 8.70e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15417    10 IYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15417    90 LLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTF 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15417   170 ISQVVLFLVAVLFgVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKV 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15417   250 ASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

34-299

1.74e-87

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 263.42 E-value: 1.74e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15420    10 LYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15420    90 LLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTW 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15420   170 INEILIFAGCVFILLGpFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKI 249

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15420   250 LSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

34-304

5.39e-87

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 262.69 E-value: 5.39e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15943    24 IYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECF 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15943   104 LLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTH 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MilVEDVIHAISIL---SCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15943   184 V--NEIVLFAFAIFlgiFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSSYSLDQD 261

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKMF 304
Cdd:cd15943   262 KVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

33-302

1.11e-86

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 261.48 E-value: 1.11e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15411     9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15411    89 FLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHA-ISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15411   169 HVNEMLIFILAgLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDK 248

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15411   249 VASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

34-302

4.17e-86

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 259.93 E-value: 4.17e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15419    10 IYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15419    90 LLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTF 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M-ILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15419   170 InELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKV 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15419   250 VSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

34-293

2.12e-85

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 257.54 E-value: 2.12e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15431    10 VYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMStLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15431    90 LLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMP-LHFCGPNVINHFFCEVQALLKLACSDTS 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 miLVEDVIHAISILSCV---SIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15431   169 --LNEILMFATSIFTLLlpfSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQD 246

                         250       260
                  ....*....|....*....|...
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15431   247 KIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

14-304

2.34e-85

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 258.36 E-value: 2.34e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  14 FSDFPQFEdggLLLFILLLCVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTIS 93
Cdd:cd15410     6 FTDYPELQ---VPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  94 FIGCLMQMYFFHSFGVTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQ 173
Cdd:cd15410    83 YSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 174 IHQLFCDLEPVLLLACTDTSMILVEDVIHAISI-LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFG 252
Cdd:cd15410   163 INHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNeASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHG 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195670839 253 SVALMYLRFSVTFQPLLEKVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKMF 304
Cdd:cd15410   243 TILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

35-299

2.16e-84

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 255.40 E-value: 2.16e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15429    11 YLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS- 193
Cdd:cd15429    91 LAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSl 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 ---MILVEDVIhaISILSCvSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15429   171 nevAILVSSVV--VLLTPC-FLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQE 247

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15429   248 KMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

35-293

3.31e-84

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 254.92 E-value: 3.31e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15915    11 YLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAML 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS- 193
Cdd:cd15915    91 LAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSl 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 -MILVEDVIHAISILSCVsIISLSYLRIITVVLKIP-SGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15915   171 nLWLLNIVTGSIALGTFI-LTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDR 249

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15915   250 IVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

34-300

8.26e-84

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 253.89 E-value: 8.26e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15424    10 IYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15424    90 LLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 miLVEDVIHAIS---ILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15424   170 --ITEAIVFGAGvliLLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRD 247

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15424   248 KQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

34-299

2.67e-83

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 252.47 E-value: 2.67e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15421    10 IFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15421    90 LLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 miLVEDVIHAISI---LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15421   170 --AYETVVYVSGVlflLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQD 247

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15421   248 KVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

34-293

4.56e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 249.21 E-value: 4.56e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15430    10 MYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15430    90 LLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDIS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 miLVEDVIHAISILSCVS---IISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15430   170 --LNEIIMLVGNIIFLVIpllLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISD 247

                         250       260
                  ....*....|....*....|...
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15430   248 KLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

35-293

3.57e-81

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 246.77 E-value: 3.57e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15947    11 YLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15947    91 LAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 ILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKVI 273
Cdd:cd15947   171 NELELFVASVFFLLVpLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFI 250

                         250       260
                  ....*....|....*....|
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15947   251 SLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

34-302

1.82e-80

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 245.39 E-value: 1.82e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15409    10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15409    90 LLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M--ILVEDVIHAISILSCVSIIsLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15409   170 IneLVLFIFSGSIQVFTILTVL-ISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDM 248

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15409   249 MDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

34-302

1.32e-79

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 243.46 E-value: 1.32e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15412    10 IYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT- 192
Cdd:cd15412    90 MLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTy 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 ----SMIlvedVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPL 268
Cdd:cd15412   170 vketAMF----IVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVE 245

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195670839 269 LEKVIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15412   246 QSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

34-303

2.02e-79

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 243.04 E-value: 2.02e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGN-AMIFLaVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15406    19 IYVVTVVGNlGMILL-ITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAEC 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15406    98 YMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSST 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SmiLVEDVIHAIS---ILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15406   178 Y--INELLLFIVGgfnVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQ 255

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKM 303
Cdd:cd15406   256 EKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

33-308

5.40e-79

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 241.95 E-value: 5.40e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15414     9 LVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15414    89 FLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SM--ILVEDVIHAISILSCVSIIsLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15414   169 QInkWVLFIMAGALGVLSGLIIL-VSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLD 247

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKMFGSQK 308
Cdd:cd15414   248 KVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

34-302

9.15e-79

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 241.57 E-value: 9.15e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15945    23 VYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15945   103 LLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQ 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15945   183 INeLLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSLDTDKM 262

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15945   263 TSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

33-300

3.84e-78

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 239.40 E-value: 3.84e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15234     9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15234    89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SM-ILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15234   169 LInNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTA 248

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15234   249 VASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

34-293

6.15e-78

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 238.65 E-value: 6.15e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15939    10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15939    90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI--LVEDVIHAISILSCVsIISLSYLrIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLEK 271
Cdd:cd15939   170 VIglLVVANSGLICLLSFL-ILLISYI-VILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP--IDK 245

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15939   246 VVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

33-293

4.53e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 236.39 E-value: 4.53e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15232     9 FLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15232    89 LLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 S----MILVEDVIhaISILSCVSIIsLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPL 268
Cdd:cd15232   169 SlneiMAFVADVF--FGVGNFLLTL-TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPE 245

                         250       260
                  ....*....|....*....|....*
gi 1195670839 269 LEKVIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15232   246 KDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

34-293

5.50e-77

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 236.22 E-value: 5.50e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15946    10 IYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15946    90 LFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15946   170 LNeMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKK 249

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15946   250 ISLFYNVFTALLNPVIYSLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

33-302

2.52e-76

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 234.95 E-value: 2.52e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15416     9 VIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15416    89 FLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15416   169 RLAkILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNK 248

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15416   249 VVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

34-302

6.34e-76

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 233.85 E-value: 6.34e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15415    10 IYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15415    90 LLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M----ILVEDVIHAISILscvSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15415   170 InellLLTFSGVIAMSTL---LTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQ 246

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15415   247 EKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

35-300

2.69e-75

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 232.37 E-value: 2.69e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15432    11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15432    91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 ILVE-DVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKVI 273
Cdd:cd15432   171 NEAElFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMV 250

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15432   251 ALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

34-293

6.08e-75

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 231.18 E-value: 6.08e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15940    10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15940    90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYLRIITVVLKIpSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLEKV 272
Cdd:cd15940   170 LIDILIVSNSGLIsLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFS--EDKV 246

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15940   247 VSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

34-302

6.11e-75

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 231.44 E-value: 6.11e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15413    10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15413    90 LLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15413   170 EKeLIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKM 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15413   250 ASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

35-300

7.88e-75

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 231.17 E-value: 7.88e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15228    11 YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15228    91 YTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 I-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTfqPLLEKVI 273
Cdd:cd15228   171 AeTVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS--PVLVTPV 248

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15228   249 QIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

34-300

1.06e-74

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 230.83 E-value: 1.06e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15428    10 IYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15428    90 LLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15428   170 QAEMAMFIMCVFTLVLpVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKM 249

                         250       260
                  ....*....|....*....|....*...
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15428   250 ISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

34-293

2.67e-74

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 229.40 E-value: 2.67e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15226    10 FYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15226    90 LLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M--ILVEDVIHAISiLSCVSIISLSYLrIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFqpLLEK 271
Cdd:cd15226   170 VleLMVVANSGLIS-LVCFLLLLISYI-VILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF--PVDK 245

                         250       260
                  ....*....|....*....|..
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15226   246 FLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

35-300

1.75e-73

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 227.65 E-value: 1.75e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15434    11 YLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15434    91 LAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 IlvEDVIHAISI---LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15434   171 Y--EATIFALGVfilLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGK 248

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15434   249 FLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

33-300

1.70e-72

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 225.02 E-value: 1.70e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKE-KTISFIGCLMQMYFFHSFGVTE 111
Cdd:cd15916     9 IIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 112 SLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTD 191
Cdd:cd15916    89 CFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 192 TSM-ILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLE 270
Cdd:cd15916   169 TTInELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEA--LD 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15916   247 GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

33-302

3.46e-70

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 219.27 E-value: 3.46e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15418    10 LSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSEC 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15418    90 FLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 -SMILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEK 271
Cdd:cd15418   170 rVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDK 249

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15418   250 VVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

34-300

5.49e-69

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 216.13 E-value: 5.49e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15405    10 IYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15405    90 VLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15405   170 VNeLVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKV 249

                         250       260
                  ....*....|....*....|....*...
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15405   250 SSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

34-304

1.98e-67

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 212.72 E-value: 1.98e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15944    23 IYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15944   103 VLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTH 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15944   183 INEILLYVFCGFVeMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLRPTSVYSLDQDKW 262

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAIKKMF 304
Cdd:cd15944   263 ASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

33-300

9.30e-67

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 210.37 E-value: 9.30e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15942     9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAEC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15942    89 FLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVtfQPLLEK 271
Cdd:cd15942   169 AFNeLVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS--QDPLDG 246

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15942   247 VVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

34-300

1.08e-66

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 210.39 E-value: 1.08e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15236    10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15236    90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M----ILVEDVIHAISILSCvsiISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLL 269
Cdd:cd15236   170 LnelvIFTEGGLLFVLPLLL---ILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDK 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15236   247 DIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

33-293

9.70e-66

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 207.57 E-value: 9.70e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15936     9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15936    89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPllEKV 272
Cdd:cd15936   169 FLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM--DKA 246

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15936   247 VSVLYTVITPMLNPMIYTLRN 267

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

34-300

2.47e-65

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 206.57 E-value: 2.47e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15233    10 AYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15233    90 LLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MI-LVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15233   170 LNeLLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKV 249

                         250       260
                  ....*....|....*....|....*...
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15233   250 IGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

34-302

3.83e-65

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 206.50 E-value: 3.83e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15407    10 IYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTD-- 191
Cdd:cd15407    90 LLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDih 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 192 -TSMILVedVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLE 270
Cdd:cd15407   170 iSEIVLF--FLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTD 247

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAIKK 302
Cdd:cd15407   248 KMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

33-300

1.62e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 204.83 E-value: 1.62e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15223     9 LLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15223    89 SILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISIL-SCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLL 269
Cdd:cd15223   169 TINSIYGLAVAWLIVgSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPPDV 248

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15223   249 HVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

34-300

1.65e-62

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 199.69 E-value: 1.65e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHN-PMYSFISIFSFLEICYTTVTIPQMLYNLVSKE-KTISFIGCLMQMYFFHSFGVTE 111
Cdd:cd15941    10 IYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLASTE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 112 SLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTD 191
Cdd:cd15941    90 CFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACAD 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 192 TS----MILVEDvihAISILSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTfqP 267
Cdd:cd15941   170 TTinelVILANI---GIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSS--Q 244

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195670839 268 LLEKVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15941   245 AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

34-296

6.60e-61

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 195.20 E-value: 6.60e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15917    10 MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15917    90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISIL-SCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLLE 270
Cdd:cd15917   170 VNSIYGLFVALLIVgFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHHVPPHVH 249

                         250       260
                  ....*....|....*....|....*.
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDM 296
Cdd:cd15917   250 ILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

33-294

2.52e-60

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 193.87 E-value: 2.52e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15222     9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15222    89 SVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SmilVEDVIHAISILSCVSI----ISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFG---SVALMYlRFSVTF 265
Cdd:cd15222   169 R---VNSIYGLFVVLSTMGLdsllILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVH-RFGKHA 244

                         250       260
                  ....*....|....*....|....*....
gi 1195670839 266 QPLLEKVIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15222   245 SPLVHVLMANVYLLVPPVLNPIIYSVKTK 273

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

34-293

5.17e-60

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 192.78 E-value: 5.17e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15938    10 AYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15938    90 LLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYlriITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLEKV 272
Cdd:cd15938   170 VTELLMVSNSGLIsTVCFVVLVTSY---TTILVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP--VDKH 244

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15938   245 VSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

35-300

6.42e-60

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 192.70 E-value: 6.42e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15433    11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15433    91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 ILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKVI 273
Cdd:cd15433   171 TEVQMFVARVVILLLpAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFV 250

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15433   251 SLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

35-293

8.31e-58

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 187.28 E-value: 8.31e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHN-PMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15935    11 YAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15935    91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYlRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLEKV 272
Cdd:cd15935   171 VVEVLMVANSGLLsLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS--VDKV 247

                         250       260
                  ....*....|....*....|.
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15935   248 ASVFYTLITPALNPLIYTLRN 268

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

35-294

8.75e-58

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 187.24 E-value: 8.75e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15950    11 YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15950    91 LLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRP 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 ILVEDVIHAISILSCVSI-ISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFF-GSVALMYL-RFSVTFQPLLEK 271
Cdd:cd15950   171 SSLYSITGSTLVVGTDSAfIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTqRFGQGVPPHTQV 250

                         250       260
                  ....*....|....*....|...
gi 1195670839 272 VIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15950   251 LLADLYLLVPPMLNPIIYGMRTK 273

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

33-294

1.48e-57

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 186.70 E-value: 1.48e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15953     9 LMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15953    89 AVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLL 269
Cdd:cd15953   169 TINRIYGLVVALLVVGLdLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGIAPHI 248

                         250       260
                  ....*....|....*....|....*
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15953   249 HIILANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

34-294

2.10e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 183.74 E-value: 2.10e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15952    10 VYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15952    90 VLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIhAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLLE 270
Cdd:cd15952   170 INIIYGLF-AISVLVLdVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNIPRYIH 248

                         250       260
                  ....*....|....*....|....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15952   249 ILLANLYVVLPPMLNPVIYGVRTK 272

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

35-293

1.57e-55

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 181.09 E-value: 1.57e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  35 YLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLV 114
Cdd:cd15937    11 YLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSM 194
Cdd:cd15937    91 LVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYT 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 195 I-LVEDVIHAISILSCVSIISLSYlRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQplLEKVI 273
Cdd:cd15937   171 VeLLMFSNSGLVILLCFLLLLISY-AFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFP--MDKVV 247

                         250       260
                  ....*....|....*....|
gi 1195670839 274 ALMFAVLAPFFNPIIYSLRN 293
Cdd:cd15937   248 AVFHTVIFPLLNPMIYTLRN 267

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

33-294

1.11e-53

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 176.77 E-value: 1.11e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15951     9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15951    89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLL 269
Cdd:cd15951   169 RVSRAYGLSVAFLVGGLdVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRFGHNVPPHV 248

                         250       260
                  ....*....|....*....|....*
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15951   249 HILIANVYLLVPPMLNPIIYGVRTK 273

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

33-294

4.91e-53

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 175.17 E-value: 4.91e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd15221     9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15221    89 AILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLL 269
Cdd:cd15221   169 TVNIWYGLTVALLTVGLdVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHIPRHV 248

                         250       260
                  ....*....|....*....|....*
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNK 294
Cdd:cd15221   249 HILLANLYVLVPPMLNPIVYGVKTK 273

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

34-304

2.29e-49

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 165.75 E-value: 2.29e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSCVSI-ISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLLE 270
Cdd:pfam13853 164 VNNIYGLFVVTSTFGIDSLlIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLLQ 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMKDAIKKMF 304
Cdd:pfam13853 244 IMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

34-297

1.62e-47

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 160.84 E-value: 1.62e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15948    11 AFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15948    91 VLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLLE 270
Cdd:cd15948   171 FNNIYGIAVALFIVGLdLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVAPHVH 250

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDMK 297
Cdd:cd15948   251 ILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

34-296

8.18e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 148.47 E-value: 8.18e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15956    10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15956    90 VLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISI-LSCVSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFF--GSVALMYLRFSVTFQPLLE 270
Cdd:cd15956   170 VDSLYGLALALFIgGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYipGLLSVLMHRFGHSVPSAAH 249

                         250       260
                  ....*....|....*....|....*.
gi 1195670839 271 KVIALMFAVLAPFFNPIIYSLRNKDM 296
Cdd:cd15956   250 VLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

34-296

1.76e-42

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 147.66 E-value: 1.76e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15954    10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTS 193
Cdd:cd15954    90 VLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 M-----ILVEDVIHAISILScvsiISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RF-SVTF 265
Cdd:cd15954   170 VdaiygLMVALLIGGFDILC----ISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahRFgGHHI 245

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195670839 266 QPLLEKVIALMFAVLAPFFNPIIYSLRNKDM 296
Cdd:cd15954   246 TPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-297

1.98e-42

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 148.00 E-value: 1.98e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  10 TEFYFSDFPQFEDGGLLLFILLLCVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKE 89
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  90 KTISFIGCLMQMYFFHSFGVTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFC 169
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 170 GPNQIHQLFCDLEPVLLLACTDTSMILVEDVIHAISILSCVSI-ISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFV 248
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLfIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195670839 249 LFFGSVALMYL--RFSVTFQPLLEKVIALMFAVLAPFFNPIIYSLRNKDMK 297
Cdd:cd15949   242 AFYVPIAVSSLihRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

34-296

1.25e-37

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 134.90 E-value: 1.25e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15955    10 MFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMS-TLPFCGPNQIHQLFCDLEPVLLLACTDT 192
Cdd:cd15955    90 ILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAADDV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSC-VSIISLSYLRIITVVLKIPSGESRQKAFSTCSAHITIFVLFFGSVALMYL--RFSVTFQPLL 269
Cdd:cd15955   170 RVNKIYGLFVAFSILGFdIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVAPYV 249

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 270 EKVIALMFAVLAPFFNPIIYSLRNKDM 296
Cdd:cd15955   250 HILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-289

4.90e-29

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 111.62 E-value: 4.90e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  41 GNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQML-YNLVSKEKTISFIGCLMQMYFFHSFGVTESLVLTIMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 120 IDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIhqlFCDLEPVLLLACTDTSMIlved 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSKPVSYTL---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 200 VIHAISILSCVSIISLSYLRIITVVLKIPS-------GESRQKAFSTCSAHITIFVLFFGSVALMYLRFSVTFQPLLEKV 272
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233

                         250       260
                  ....*....|....*....|...
gi 1195670839 273 I------ALMFAVLAPFFNPIIY 289
Cdd:pfam00001 234 LdkalsvTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

36-293

2.78e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 80.03 E-value: 2.78e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVL 115
Cdd:cd00637    10 VVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 116 TIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLactdtSMI 195
Cdd:cd00637    90 TAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAY-----TIF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 196 LVedvihAISILSCVSIISLSYLRIITVVLK--------------IPSGESRQKAFSTCSAHITIFVLFFG--SVALMYL 259
Cdd:cd00637   165 LF-----VLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCWLpyFILLLLD 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195670839 260 RFSVTFQPLLEKV--IALMFAVLAPFFNPIIYSLRN 293
Cdd:cd00637   240 VFGPDPSPLPRILyfLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

36-300

3.57e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 65.28 E-value: 3.57e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVL 115
Cdd:cd14967    11 LVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 116 TIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPnqihqlfcdlepvlllacTDTSMI 195
Cdd:cd14967    91 CAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSV------------------VDCECE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 196 LVEDVIHAIsILSCVS------IISLSYLRIITVVLKipsgesRQKAFSTCSAHITIFVL----FFgsVALMYLRFSVTF 265
Cdd:cd14967   153 FTPNKIYVL-VSSVISffipllIMIVLYARIFRVARR------ELKAAKTLAIIVGAFLLcwlpFF--IIYLVSAFCPPD 223

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195670839 266 QPLLEK-VIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd14967   224 CVPPILyAVFFWLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

36-299

4.08e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 56.49 E-value: 4.08e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPqmLYNLVSKEKTISFIGCLmqmyFFHSFGV--TESL 113
Cdd:cd14968    12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCL----FMACLVLvlTQSS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAI--DRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM-LLPEIVWMSTLPFCGPNQIHQLFCDLEPVLllacT 190
Cdd:cd14968    86 IFSLLAIaiDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgLTPMFGWNNGAPLESGCGEGGIQCLFEEVI----P 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 191 DTSMILvedVIHAISILSCVSIISLSYLRIITVVLKipsgESRQKAFSTCSAH-----------ITIFVLFFGSVALMYL 259
Cdd:cd14968   162 MDYMVY---FNFFACVLVPLLIMLVIYLRIFRVIRK----QLRQIESLLRSRRsrstlqkevkaAKSLAIILFLFALCWL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195670839 260 RFSVT-----FQPLLEK-VIALMFAVLAPFF----NPIIYSLRNKDMKDA 299
Cdd:cd14968   235 PLHIIncitlFCPECKVpKILTYIAILLSHAnsavNPIVYAYRIRKFRQT 284

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

33-299

1.90e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 51.52 E-value: 1.90e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFI-------------SIFSFLEICYTTVTIPQMLYNlvskektisFIGCLM 99
Cdd:cd14972     7 VLGVFIVVENSLVLAAIIKNRRLHKPMYILIanlaaadllagiaFVFTFLSVLLVSLTPSPATWL---------LRKGSL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 100 QMYFFHSFGvteSLVLTimAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM-LLPEIVWMSTLPFCGpnqihqlf 178
Cdd:cd14972    78 VLSLLASAY---SLLAI--AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLaLLPVLGWNCVLCDQE-------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 179 cdlepvlllACTDTSMILVEDVIH--AISILSCVSIISLSYLRIITVVLKIPSGESR--------QKAFSTCSAH--ITI 246
Cdd:cd14972   145 ---------SCSPLGPGLPKSYLVliLVFFFIALVIIVFLYVRIFWCLWRHANAIAArqeaavpaQPSTSRKLAKtvVIV 215

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195670839 247 FVLFFGS----VALMYLRFSVTFQPLLEKV--IALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd14972   216 LGVFLVCwlplLILLVLDVLCPSVCDIQAVfyYFLVLALLNSAINPIIYAFRLKEMRRA 274

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

33-300

1.85e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 48.36 E-value: 1.85e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTES 112
Cdd:cd14969     9 LIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYaIIITPKLCTQLSTGSFTLGFLmllpeivWmSTLPFCGPNQIhqlfcDLEPVlllaCTDT 192
Cdd:cd14969    89 STLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLF-------W-ALPPLFGWSSY-----VPEGG----GTSC 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 193 SMILVEDVIHAISILSC---------VSIISLSYLRIITVVLKIPSGESR----QKAFSTCSAHITIFVLFFGSV----- 254
Cdd:cd14969   151 SVDWYSKDPNSLSYIVSlfvfcfflpLAIIIFCYYKIYRTLRKMSKRAARrknsAITKRTKKAEKKVAKMVLVMIvafli 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195670839 255 -----ALMYLRFSVTFQPLLEK---VIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd14969   231 awtpyAVVSLYVSFGGESTIPPllaTIPALFAKSSTIYNPIIYVFMNKQFRRAL 284

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

36-299

5.87e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 46.97 E-value: 5.87e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIP-QMLYNLVSKEKTISFIGCLMqmyfFHSFGVTES-- 112
Cdd:cd15067    11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDV----WHSFDVLASta 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 --LVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFcdlepvlllacT 190
Cdd:cd15067    87 siLNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLF-----------T 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 191 DTSMILVedvihaisILSCVS------IISLSYLRIITVVLKipsgesRQKAFSTCSAHITIFVL----FFGSVALMYLR 260
Cdd:cd15067   156 DDSGYLI--------FSSCVSfyiplvVMLFTYYRIYRAAAK------EQKAAKTLGIVMGVFILcwlpFFVTNILIGFC 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195670839 261 FSVTFQPllEKVIALMFAVLA---PFFNPIIYSLRNKDMKDA 299
Cdd:cd15067   222 PSNCVSN--PDILFPLVTWLGyinSGMNPIIYACSSRDFRRA 261

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

76-172

1.76e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 45.54 E-value: 1.76e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  76 VTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM 155
Cdd:cd15094    51 IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLV 130

                          90
                  ....*....|....*..
gi 1195670839 156 LLPEIVWMSTLPFCGPN 172
Cdd:cd15094   131 MLPIILYASTVPDSGRY 147

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

34-162

4.29e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 44.34 E-value: 4.29e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15050    10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVW 162
Cdd:cd15050    90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGW 138

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

34-137

8.67e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 43.59 E-value: 8.67e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGClmqmYFFHS---FGVT 110
Cdd:cd15058    10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWC----ELWTSvdvLCVT 85

                          90       100
                  ....*....|....*....|....*...
gi 1195670839 111 ESL-VLTIMAIDRYVAICNPLRYAIIIT 137
Cdd:cd15058    86 ASIeTLCVIAVDRYIAITRPLRYQVLLT 113

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

34-137

1.01e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 43.23 E-value: 1.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPqmLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15070    10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIM 87

                          90       100
                  ....*....|....*....|....
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIIT 137
Cdd:cd15070    88 SLLAIAVDRYLRVKLTVRYRIVTT 111

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

39-299

1.16e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 43.04 E-value: 1.16e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  39 VVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVLTIM 118
Cdd:cd15330    15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 119 AIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIV-WMSTLPFCGPNqihqlfcdlepvlllACTdtsmiLV 197
Cdd:cd15330    95 ALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPD---------------ACT-----IS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 198 EDviHAISILSCVSIISLSYLRIITVVLKIPSGESRQ-KAFSTCSAHITIFVL----FFGSVALMYLRFSVTFQPLLEKV 272
Cdd:cd15330   155 KD--PGYTIYSTFGAFYIPLILMLVLYGRIFKAAARErKTVKTLGIIMGTFILcwlpFFIVALVLPFCESTCHMPELLGA 232

                         250       260
                  ....*....|....*....|....*..
gi 1195670839 273 IALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15330   233 IINWLGYSNSLLNPIIYAYFNKDFQSA 259

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

34-139

1.69e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 42.59 E-value: 1.69e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd14993    10 VFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVL 89

                          90       100
                  ....*....|....*....|....*.
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPK 139
Cdd:cd14993    90 TLVAISIDRYLAICYPLKARRVSTKR 115

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

34-184

1.74e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 42.62 E-value: 1.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLynLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15068    10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM-LLPEIVWMSTLP---------FCGPNQIHQLFCDLEP 183
Cdd:cd15068    88 SLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIgLTPMLGWNNCGQpkegknhsqGCGEGQVACLFEDVVP 167


                  .
gi 1195670839 184 V 184
Cdd:cd15068   168 M 168

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

34-300

1.82e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 42.43 E-value: 1.82e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15012     9 VFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQlfcdlEPVLLLACTDTS 193
Cdd:cd15012    89 ILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE-----EEICVLDREMFN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 194 MILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQK----------AFSTCSahITIFVLFFGSVALMYLRFSV 263
Cdd:cd15012   164 SKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKvvrllvavvvSFALCN--LPYHARKMWQYWSEPYRCDS 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195670839 264 TFQPLLEkVIALMFAVLAPFFNPIIYSLRNKDMKDAI 300
Cdd:cd15012   242 NWNALLT-PLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

36-299

5.75e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 40.68 E-value: 5.75e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVL 115
Cdd:cd15321    18 LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 116 TIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWM-------STLPFCGPNQihqlfcdlEPVLLLA 188
Cdd:cd15321    98 CAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKgkqkdeqGGLPQCKLNE--------EAWYILS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 189 CTDTSMilvedvihaisILSCVsIISLSYLRIITVvlkipsGESRQKAFS-TCSAHITIFVL----FFgsvalmylrFSV 263
Cdd:cd15321   170 SSIGSF-----------FAPCL-IMILVYLRIYLI------AKNREKRFTfVLAVVIGVFVLcwfpFF---------FSY 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195670839 264 TFQPLLEKVIALMFAVLAPFF---------NPIIYSLRNKDMKDA 299
Cdd:cd15321   223 SLGAICPELCKVPHSLFQFFFwigycnsslNPVIYTIFNQDFRRA 267

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

39-297

7.44e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 40.69 E-value: 7.44e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  39 VVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLynLVSKEKTISFIGCLMQMYFFHSFGVTESLVLTIM 118
Cdd:cd15069    15 VAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 119 AIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM-LLPEIVWMSTLPFCGPNQIHQLFCDLEPVLLLACTDTSMILV 197
Cdd:cd15069    93 AVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIgLTPFLGWNKAMSATNNSTNPADHGTNHSCCLISCLFENVVPM 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 198 EDVIHaISILSCV----SIISLSYLRIITVVLKIPS-----GESR---QKAFSTCSAHITIFVLF-FGSVALMYLRFSVT 264
Cdd:cd15069   173 SYMVY-FNFFGCVlpplLIMLVIYIKIFLVACRQLQrtelmDHSRttlQREIHAAKSLAIIVGIFaLCWLPVHILNCITL 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195670839 265 FQPLLEKV-------IALMFAVLAPFFNPIIYSLRNKDMK 297
Cdd:cd15069   252 FQPEFSKSkpkwamnVAILLSHANSVVNPIVYAYRNRDFR 291

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

39-162

9.10e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 40.22 E-value: 9.10e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  39 VVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPqmLYNLVSKEKTISFIGCLMQMYFFHSFGVTESLVLTIM 118
Cdd:cd15071    15 VPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILALLAI 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195670839 119 AIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLM-LLPEIVW 162
Cdd:cd15071    93 AVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVgLTPMFGW 137

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

36-137

9.71e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 40.39 E-value: 9.71e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGClmQMYFF--HSFGVTESL 113
Cdd:cd15083    12 LIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFsgGLFGIMSIN 89

                          90       100
                  ....*....|....*....|....
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIIT 137
Cdd:cd15083    90 TLAAIAVDRYLVITRPMKASVRIS 113

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

110-168

9.88e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 39.97 E-value: 9.88e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195670839 110 TESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPF 168
Cdd:cd14970    85 TSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQE 143

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

34-179

1.27e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 39.80 E-value: 1.27e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEI-----CYTTVTIPQMLYNLVSKEKTisfigCLMQMYFFHSFG 108
Cdd:cd15979    10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMGTFIFGEVI-----CKAVAYLMGVSV 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195670839 109 VTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFC 179
Cdd:cd15979    85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQC 155

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

33-137

1.32e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 39.87 E-value: 1.32e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  33 CVYLFI--VVGNAMIFLAVQ--LDVRLHNPMYSFISIFSFLEIcytTVTIPQMLYNLvSKEKTISFIGCLMQMYFFHSFG 108
Cdd:cd15131     7 CVLLFVvgVTGNLMTMLVVSkyRDMRTTTNLYLSSMAFSDLLI---FLCMPLDLYRL-WQYRPWNFGDLLCKLFQFVSES 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1195670839 109 VTESLVLTIMA--IDRYVAICNPLRYAIIIT 137
Cdd:cd15131    83 CTYSTILNITAlsVERYFAICFPLRAKVVVT 113

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

34-299

1.33e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 39.63 E-value: 1.33e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYfFHSFGVTESL 113
Cdd:cd15059    10 VILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLA-LDVLFCTASI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 114 V-LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIV-------WMSTLPFCGPNqihqlfcDLEPVL 185
Cdd:cd15059    89 VnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFgwkdeqpWHGAEPQCELS-------DDPGYV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 186 LLACTdtsmilvedvihaISILSCVSIISLSYLRIITVVLKipsgesRQKAFSTCSAH-ITIFVL----FFGSVALMYLR 260
Cdd:cd15059   162 LFSSI-------------GSFYIPLLIMIIVYARIYRAAKR------KERRFTLVLGVvMGAFVLcwlpFFFTYPLVVVC 222

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195670839 261 FSVTFQPLLEKViALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15059   223 KTCGVPELLFKF-FFWLGYCNSALNPVIYTIFNKDFRRA 260

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

85-299

2.17e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 39.28 E-value: 2.17e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  85 LVSKEKTISFIgCLMQMYFFHSFGVTESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTG----SFTLGFL-MLLPE 159
Cdd:cd15104    62 LSDGENTQKVL-CLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGlwlySGLIGFLpLISPQ 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 160 IVWMSTLPFCGpnqIHQLFcDLEPVLLLACtdtsMILVEDVIHAISILSCVSIISLSYLRIITVVLKIPSGESRQKAF-S 238
Cdd:cd15104   141 FQQTSYKGKCS---FFAAF-HPRVLLVLSC----MVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRTlS 212

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195670839 239 TCSAHITIFVLfFGSVALMYLRFSVT----------FQPLLEKVIALMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15104   213 DFKAARTVAVL-IGCFLLSWLPFQITglvqalcdecKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRA 282

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

110-174

2.17e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 38.97 E-value: 2.17e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1195670839 110 TESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQI 174
Cdd:cd15088    86 TSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTF 150

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

115-139

2.90e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 38.69 E-value: 2.90e-03

                          10        20
                  ....*....|....*....|....*
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIITPK 139
Cdd:cd15055    91 LVLIAIDRYVAVCDPLLYPTKITIR 115

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

34-134

3.13e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 38.60 E-value: 3.13e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTI-SFIGCLMQMYFFHSFGVTES 112
Cdd:cd15212    10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACFGIVST 89

                          90       100
                  ....*....|....*....|..
gi 1195670839 113 LVLTIMAIDRYVAICNPLRYAI 134
Cdd:cd15212    90 LTMTLISFDRYYAIVRQPQGKI 111

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

34-179

3.64e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 38.41 E-value: 3.64e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFFHSFGVTESL 113
Cdd:cd15001     9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVL 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195670839 114 VLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTLPFCGPNQIHQLFC 179
Cdd:cd15001    89 TLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC 154

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

34-161

4.53e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 37.98 E-value: 4.53e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFIS-------IFSFLEIcyttvtIPQMLYNLvskekTISFIG----CLMqMY 102
Cdd:cd15196    10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILhlsvadlLVALFNV------LPQLIWDI-----TYRFYGgdllCRL-VK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 103 FFHSFGV-TESLVLTIMAIDRYVAICNPLRYaIIITPKLCTQLSTGSFTLGFLMLLPEIV 161
Cdd:cd15196    78 YLQVVGMyASSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLF 136

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

36-137

4.73e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 37.96 E-value: 4.73e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGCLMQMYFfHSFGVTESL-V 114
Cdd:cd15959    12 LVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSV-DVLCVTASIeT 90

                          90       100
                  ....*....|....*....|...
gi 1195670839 115 LTIMAIDRYVAICNPLRYAIIIT 137
Cdd:cd15959    91 LCAIAVDRYLAITNPLRYEALVT 113

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

34-168

5.16e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 38.04 E-value: 5.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  34 VYLFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTI--SFIgCLMQMYFFHSfgVTE 111
Cdd:cd14997    10 IFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLlgEFM-CKLVPFVELT--VAH 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195670839 112 SLVLTIMAI--DRYVAICNPLRyaiiitpklCTQLSTGSFTLGFLMLLPEIVWMSTLPF 168
Cdd:cd14997    87 ASVLTILAIsfERYYAICHPLQ---------AKYVCTKRRALVIIALIWLLALLTSSPV 136

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

36-299

5.21e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 37.69 E-value: 5.21e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGClmqmYFFHSFGV---TES 112
Cdd:cd15064    12 LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC----DIWISLDVtccTAS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 113 LV-LTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTlpfcgPNQIHQLFCdlepvlllactd 191
Cdd:cd15064    88 ILhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRT-----PDSEDPSEC------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 192 tsmILVEDVIHAisILSCVSIISLSYLRIITVVLKIPSGESR-QKAFSTCSAHITIFVL----FFGSVALMYLRFSVTFQ 266
Cdd:cd15064   151 ---LISQDIGYT--IFSTFGAFYIPLLLMLILYWKIYRAAAReRKAAKTLGIILGAFIVcwlpFFLVALIVPLCSHCWIP 225

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195670839 267 PLLEKVIaLMFAVLAPFFNPIIYSLRNKDMKDA 299
Cdd:cd15064   226 LALKSFF-LWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

36-298

5.45e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 37.91 E-value: 5.45e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSF----LEICYTTVTIPQMLYNLVSKEKTIsfigCLMQMYFFHSFGVTE 111
Cdd:cd15085    12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFsdlmMALCGTTIVTVTNYEGYFYLGDAF----CIFQGFAVNYFGIVS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 112 SLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVWMSTlpfcGPNQIhQLFCDLEPVLLLACTD 191
Cdd:cd15085    88 LWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSY----GPEGV-QTSCSIGWEERSWSNY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839 192 TSMILVedvihaisILSC----VSIISLSYLRIITVVLKIPSGESRQ--KAFSTCSAHITIFVLF----FGSVALMYLRF 261
Cdd:cd15085   163 SYLILY--------FLMCfvipVAIIGFSYGNVLRSLHKLNKKIEQQggKNCPEEEERAVIMVLAmviaFLICWLPYTVF 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1195670839 262 S--VTFQPLLE-----KVIALMFAVLAPFFNPIIYSLRNKDMKD 298
Cdd:cd15085   235 AliVVVNPELSisplaATMPTYFAKTSPVYNPIIYIFLNKQFRE 278

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

36-140

6.91e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 37.64 E-value: 6.91e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195670839  36 LFIVVGNAMIFLAVQLDVRLHNPMYSFISIFSFLEICYTTVTIPQMLYNLVSKEKTISFIGClmqmYFFHSFGV---TES 112
Cdd:cd15329    12 LGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILC----DVWISFDVllcTAS 87

                          90       100
                  ....*....|....*....|....*....
gi 1195670839 113 LV-LTIMAIDRYVAICNPLRYAIIITPKL 140
Cdd:cd15329    88 ILnLCAISVDRYLVITRPLTYAVKRTPKR 116

7tmA_SSTR5

cd15974

somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...

110-162

8.39e-03

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.

Pssm-ID: 320640 [Multi-domain] Cd Length: 277 Bit Score: 37.47 E-value: 8.39e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195670839 110 TESLVLTIMAIDRYVAICNPLRYAIIITPKLCTQLSTGSFTLGFLMLLPEIVW 162
Cdd:cd15974    85 TSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIF 137

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01