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Conserved domains on  [gi|1195726176|ref|XP_021021505|]
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olfactory receptor 9A4 [Mus caroli]

Protein Classification

olfactory receptor( domain architecture ID 11610373)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 25-294 1.12e-134

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320578  Cd Length: 270  Bit Score: 382.60  E-value: 1.12e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15912     2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLS-GKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
 
Name Accession Description Interval E-value
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 25-294 1.12e-134

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 382.60  E-value: 1.12e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15912     2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLS-GKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 30-260 5.44e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 123.00  E-value: 5.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVL-GIFWFGLREISFEACLTQMFFIHKFSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 190 NNtIFIEFILFLMAVFVLFG-SLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYV 260
Cdd:pfam13853 160 AD-IKVNNIYGLFVVTSTFGiDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSM 230
 
Name Accession Description Interval E-value
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 25-294 1.12e-134

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 382.60  E-value: 1.12e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15912     2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLS-GKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-294 6.84e-123

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 352.94  E-value: 6.84e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd13954     2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLS-GDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-301 1.59e-113

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 329.42  E-value: 1.59e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15225     2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSED-KTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 25-294 6.46e-101

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 297.11  E-value: 6.46e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15230     2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEK-KTISFAGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15230    81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15230   161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15230   241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 25-294 1.77e-99

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 293.62  E-value: 1.77e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15911     2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLT-GDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 25-301 3.10e-97

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 288.01  E-value: 3.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15231     2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLR-ERKTISYIGCLAQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15231    81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15231   161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15231   241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 26-294 4.37e-97

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 287.26  E-value: 4.37e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHL 105
Cdd:cd15224     3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLS-QNKSISFVGCMTQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15224    82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15224   162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241

                         250       260
                  ....*....|....*....|....*....
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15224   242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 25-294 7.36e-95

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 281.86  E-value: 7.36e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLH 104
Cdd:cd15237     2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSE-HKTISFVGCAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15237   241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 23-301 4.78e-94

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 279.88  E-value: 4.78e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  23 RHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLF 102
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGS-KTISYAGCLAQMY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 103 LHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRG 182
Cdd:cd15235    80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 183 QLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKP 262
Cdd:cd15235   160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQP 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195726176 263 KQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15235   240 SSSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 25-302 1.12e-93

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 279.20  E-value: 1.12e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15411     2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLS-GRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 10-302 1.61e-93

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 279.25  E-value: 1.61e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  10 EFYLVGFPGSENLRHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGM 89
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLA-EN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  90 QSISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYC 169
Cdd:cd15943    80 KTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 170 KSNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVI 249
Cdd:cd15943   160 GSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVT 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 250 IGYGCCLFLYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15943   240 IFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALR 292
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 25-294 5.70e-93

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 277.03  E-value: 5.70e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP-VMLSGLLlpGMQSISLAGCVAQLFL 103
Cdd:cd15227     2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPkSIANSLT--NTRSISFLGCVAQVFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15227    80 FIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15227   160 LLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPP 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15227   240 SDSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 25-302 2.43e-92

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 275.68  E-value: 2.43e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15417     2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFR-EQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15417   241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 11-297 6.27e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 269.96  E-value: 6.27e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  11 FYLVGFPGSENLRHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQ 90
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLL-AERK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  91 SISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCK 170
Cdd:cd15408    80 VISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 171 SNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVII 250
Cdd:cd15408   160 SNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 251 GYGCCLFLYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKV 297
Cdd:cd15408   240 FYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 24-301 3.59e-88

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 264.84  E-value: 3.59e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFL 103
Cdd:cd15229     1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLL-SERKTISVEGCIAQIFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15229    80 FFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15229   160 LLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPN 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15229   240 SASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 25-294 3.89e-88

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 264.49  E-value: 3.89e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLH 104
Cdd:cd15947     2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGP-DKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 25-301 5.71e-88

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 264.57  E-value: 5.71e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15420     2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQR-KTISFAGCGTQMYLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15420    81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15420   161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15420   241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 25-301 9.05e-88

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 264.03  E-value: 9.05e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLS-GRKSISFVGCGTQIFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15421    81 LTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLfgsLIPTIV---SYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVK 261
Cdd:cd15421   161 LKLSCADTSAYETVVYVSGVLFL---LIPFSLilaSYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMR 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195726176 262 PKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15421   238 PGSYHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 11-302 4.41e-87

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 262.98  E-value: 4.41e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  11 FYLVGFPGSENLRHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQ 90
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKML-VNFLAEDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  91 SISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCK 170
Cdd:cd15410    80 AISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 171 SNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVII 250
Cdd:cd15410   160 SNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 251 GYGCCLFLYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15410   240 FHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALR 291
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 25-294 1.57e-86

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 260.62  E-value: 1.57e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15431     2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLS-DRPTISYSRCLAQMYIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYaTFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15431    81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15431   160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15431   240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 26-301 3.82e-86

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 260.03  E-value: 3.82e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLHL 105
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAE-HKTISFASCVAQLFISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15429    82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15429   162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15429   242 SSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 25-302 5.13e-85

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 257.24  E-value: 5.13e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15419     2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLS-ESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15419   241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 26-302 7.99e-85

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 256.57  E-value: 7.99e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLHL 105
Cdd:cd15409     3 LFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFL-SKNKMISFSGCAAQFFFFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15409    82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15409   162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15409   242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 24-301 4.21e-84

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 254.61  E-value: 4.21e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFL 103
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPD-KTISYVGCAIQLFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15434    80 ALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15434   160 LIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPK 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15434   240 NSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 24-294 4.84e-84

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 254.08  E-value: 4.84e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFL 103
Cdd:cd15918     1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQT-QSKSISYAGCLTQMYF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15918    80 FLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15918   160 LLKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPP 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15918   240 SSHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 25-294 5.11e-84

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 254.15  E-value: 5.11e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15915     2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLS-EHKTISFQGCISQLHFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15915    81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIP-SASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15915   161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15915   241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 25-303 6.02e-82

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 249.24  E-value: 6.02e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLH 104
Cdd:cd15412     2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSE-KKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALRD 303
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 25-301 1.41e-80

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 245.80  E-value: 1.41e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLH 104
Cdd:cd15424     2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLL-AGNGAISFARCTTQMYIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15424    81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15424   161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15424   241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 24-294 3.26e-80

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 244.59  E-value: 3.26e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFL 103
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFL-SERKTISFSGCAVQMYL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15430    80 SLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15430   160 VLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15430   240 SKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 25-302 6.80e-80

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 243.81  E-value: 6.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15416     2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLV-EKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15416   241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 26-302 3.54e-79

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 242.23  E-value: 3.54e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHL 105
Cdd:cd15413     3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVV-EQNTISFYACATQLAFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15413    82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15413   242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALK 278
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 25-301 5.15e-78

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 239.24  E-value: 5.15e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLH 104
Cdd:cd15407     2 PLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLL-TGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAF 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 25-301 2.67e-77

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 237.38  E-value: 2.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLH 104
Cdd:cd15432     2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSP-QKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 25-294 2.72e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 237.16  E-value: 2.72e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15232     2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLT-ERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 25-307 1.69e-75

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 233.09  E-value: 1.69e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15414     2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFV-EKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALRDGVKR 307
Cdd:cd15414   241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 25-294 7.99e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 230.72  E-value: 7.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLH 104
Cdd:cd15914     2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLL-SEEKTISFNGCLLQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15914    81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15914   161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15914   241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 24-294 8.25e-75

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 230.55  E-value: 8.25e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFL 103
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLR-EHKTISFGGCMAQIFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15226    80 LHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKiPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15226   160 VIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPF 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15226   239 STFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 26-294 9.88e-75

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 230.67  E-value: 9.88e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLHL 105
Cdd:cd15913     3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSET-KTISFSGCFLQFYFFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15913    82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15913   162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                         250       260
                  ....*....|....*....|....*....
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15913   242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 25-301 1.94e-74

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 229.77  E-value: 1.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQS-KSISYTGCLTQMCFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15234    81 LLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15234   161 LKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAV 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15234   241 THSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 23-302 6.63e-74

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 228.90  E-value: 6.63e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  23 RHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLF 102
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKD-KSISFAGCAAQFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 103 LHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRG 182
Cdd:cd15418    80 FSAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 183 QLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKP 262
Cdd:cd15418   160 PLVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRP 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195726176 263 KQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15418   240 SSSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALK 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 11-302 9.78e-74

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 228.86  E-value: 9.78e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  11 FYLVGFPGSENLRHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQ 90
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAK-RK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  91 SISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCK 170
Cdd:cd15945    80 SIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 171 SNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVII 250
Cdd:cd15945   160 SNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 251 GYGCCLFLYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15945   240 FYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALK 291
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 26-302 1.06e-73

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 228.41  E-value: 1.06e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLHL 105
Cdd:cd15406    12 LFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFV-SEKNIISYPECMTQLFFFC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15406    91 VFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15406   171 KLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSS 250

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15406   251 SSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALK 287
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 26-301 2.03e-73

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 227.33  E-value: 2.03e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHL 105
Cdd:cd15916     3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKVISFGGCVAQLYFFH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15916    83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15916   163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195726176 266 QAADynRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15916   243 EALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 26-301 5.75e-73

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 226.21  E-value: 5.75e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLHL 105
Cdd:cd15428     3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSE-RKIISFIRCAAQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15428    82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15428   162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15428   242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 25-294 1.38e-72

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 225.05  E-value: 1.38e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLH 104
Cdd:cd15946     2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLL-SHKKTISFTGCVAQMYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15946    81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15946   161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15946   241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 24-294 1.65e-72

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 224.78  E-value: 1.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFL 103
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLS-ERKTISFNGCMTQLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15939    80 EHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATiLKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15939   160 LLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPV 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15939   239 TTFPID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 11-302 6.40e-72

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 224.28  E-value: 6.40e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  11 FYLVGFPGSENLRHVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQ 90
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFL-TKHK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  91 SISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCK 170
Cdd:cd15944    80 VISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 171 SNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVII 250
Cdd:cd15944   160 SNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 251 GYGCCLFLYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15944   240 FYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFK 291
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 25-301 1.88e-70

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 219.61  E-value: 1.88e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15228     2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQS-RVISLGGCMSQVFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15228    81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15228   161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADynRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15228   241 SPVLV--TPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 25-302 2.07e-69

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 217.28  E-value: 2.07e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15415     2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLV-EKKTISYSACIAQHFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15415    81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15415   161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEALR 302
Cdd:cd15415   241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 24-294 2.17e-68

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 214.12  E-value: 2.17e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFL 103
Cdd:cd15936     1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQT-KTISFNGCMAQMFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15936    80 FHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTyIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15936   160 VIKLACTDTFLLELLMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPF 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195726176 264 QTQAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15936   239 QTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 26-301 2.73e-68

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 214.22  E-value: 2.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLHL 105
Cdd:cd15942     3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFL-SGGRIISFGGCVTQLFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15942    82 FLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAML 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15942   162 KLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195726176 266 QAADynRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15942   242 DPLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 26-294 1.41e-67

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 212.30  E-value: 1.41e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHL 105
Cdd:cd15940     3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLS-EEKTISFNGCVTQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15940    82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIpSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15940   162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTS 240

                         250       260
                  ....*....|....*....|....*....
gi 1195726176 266 QAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15940   241 FSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 25-301 1.84e-66

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 209.65  E-value: 1.84e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLH 104
Cdd:cd15233     2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSH-KRTISYAACLSQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15233    81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15233   161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15233   241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 25-301 7.28e-65

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 205.41  E-value: 7.28e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15433     2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPA-LTITRGGCVAQLFIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15433    81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15433   161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15433   241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 25-301 2.30e-64

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 204.31  E-value: 2.30e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQS-PMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFL 103
Cdd:cd15941     2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGRTISFEGCVVQLYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15941    82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK 263
Cdd:cd15941   162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195726176 264 QTQAADynRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15941   242 SSQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 25-301 1.26e-61

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 197.30  E-value: 1.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLH 104
Cdd:cd15236     2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQ-TQDQSIPYAGCISQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15236    81 IFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15236   161 LKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 265 TQAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15236   241 NNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 26-294 1.30e-58

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 188.93  E-value: 1.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLHL 105
Cdd:cd15938     3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFL-SQRKAISYEACIAQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15938    82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIiatILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15938   162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                         250       260
                  ....*....|....*....|....*....
gi 1195726176 266 QAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15938   239 FPVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 26-294 2.69e-58

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 188.43  E-value: 2.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRL-QSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLH 104
Cdd:cd15935     3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCG-RTISFGGCMAQLFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15935    82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATiLKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15935   162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15935   241 SSSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 26-301 4.31e-58

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 188.01  E-value: 4.31e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPgMQSISLAGCVAQLFLHL 105
Cdd:cd15405     3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSE-KNTISYAGCMTQLFFFC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15405    82 FFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQT 265
Cdd:cd15405   162 QLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSV 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKVIEAL 301
Cdd:cd15405   242 GSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 25-294 8.00e-57

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 184.56  E-value: 8.00e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15937     2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFS-ERKTISYGGCMAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQL 184
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 185 LKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATiLKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPKQ 264
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 265 TQAADynRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15937   240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 24-294 5.48e-50

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 167.08  E-value: 5.48e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFL 103
Cdd:cd15223     1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWF-DANTISLPGCFAQMFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQ 183
Cdd:cd15223    80 IHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYV--K 261
Cdd:cd15223   160 LVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyR 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195726176 262 PKQTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd15223   240 FGKTIPPDVHVLLSVLYILIPPALNPIIYGVRT 272
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 30-252 1.89e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 152.65  E-value: 1.89e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15222     7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVL-GIFWFNAREISFDACLAQMFFIHTFSF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15222    86 MESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLAC 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1195726176 190 NNTIFIEfILFLMAVFVLFGSLIPTIV-SYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGY 252
Cdd:cd15222   166 SDTRVNS-IYGLFVVLSTMGLDSLLILlSYVLILKTVLGIASREERLKALNTCVSHICAVLIFY 228
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 30-260 9.72e-44

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 150.90  E-value: 9.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15917     7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKML-GIFWFNAREISFDACLAQMFFIHSFTA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15917    86 MESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 190 NNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYV 260
Cdd:cd15917   166 GDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFL 236
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 30-252 7.49e-43

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 148.72  E-value: 7.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15950     7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWL-GSAEISFEACFTQMFFVHSFTA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15950    86 VESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLAC 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 190 NNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFtCVIIGY 252
Cdd:cd15950   166 ADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHV-CVILLF 227
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 30-250 8.08e-43

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 148.59  E-value: 8.08e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWF-GAGEISFDGCLTQMFFVHFVFV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15221    86 TESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLAC 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 190 NNtIFIEFILFLMAVFVLFGSLIPTI-VSYTYIIATILKIPSASGRRKAFSTCASHFtCVII 250
Cdd:cd15221   166 AD-ITVNIWYGLTVALLTVGLDVVLIaVSYALILRAVFRLPSKDARLKALSTCGSHV-CVIL 225
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 30-257 1.38e-41

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 145.10  E-value: 1.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKAL-CIFWFNLKEITFSGCLTQMFFIHTLSI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNshtcNSVV----IVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd15953    86 MESAVLVAMAFDRYVAICNPLRYATILT----NSRIaklgLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVV 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 186 KLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLF 257
Cdd:cd15953   162 KLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALF 233
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-297 1.08e-39

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 140.17  E-value: 1.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLHLALG 108
Cdd:cd15951     6 PFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLS-IFWFNSREIDFSACLTQMFFIHSFS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 109 TTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLS 188
Cdd:cd15951    85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 189 CNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFtCVIIGY---GCCLFLYVKPKQT 265
Cdd:cd15951   165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHI-CVILVFyipALFSFLTHRFGHN 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195726176 266 QAADYNRVVSLMISIVTPFLKPFIFTLRNDKV 297
Cdd:cd15951   244 VPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 30-259 5.50e-39

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 138.28  E-value: 5.50e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15952     7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKML-GIFWFNLREISFGGCLAQMFFIHTFTG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15952    86 MESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLAC 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 190 NNtIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLY 259
Cdd:cd15952   166 AS-IRINIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSF 234
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 9-252 3.14e-35

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 129.13  E-value: 3.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176   9 TEFYLVGFPGSENLrHVLFAI-FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLP 87
Cdd:cd15949     2 STFILLGIPGLEPL-HVWISIpFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLL-AIFWF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  88 GMQSISLAGCVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFqIWPVYATFH-L 166
Cdd:cd15949    80 SSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLY-ISPLPLLVRrL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 167 NYCKSNVVDNFFCDRGQLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFT 246
Cdd:cd15949   159 PWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVC 238


                  ....*.
gi 1195726176 247 CVIIGY 252
Cdd:cd15949   239 AILAFY 244
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 30-297 6.89e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 124.98  E-value: 6.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15956     7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWF-GATAISSYVCLSQMFLVHAFSA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15956    86 MESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 190 NNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYVKPK--QTQA 267
Cdd:cd15956   166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRfgHSVP 245

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195726176 268 ADYNRVVSLMISIVTPFLKPFIFTLRNDKV 297
Cdd:cd15956   246 SAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 30-260 5.44e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 123.00  E-value: 5.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVL-GIFWFGLREISFEACLTQMFFIHKFSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 190 NNtIFIEFILFLMAVFVLFG-SLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLYV 260
Cdd:pfam13853 160 AD-IKVNNIYGLFVVTSTFGiDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSM 230
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 30-259 5.83e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 122.62  E-value: 5.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15954     7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWF-NLKEISFNACLVQMFFVHTFTG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLSC 189
Cdd:cd15954    86 MESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLAC 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 190 NNtIFIEFILFLMAVFVLFGSLIPTI-VSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLFLY 259
Cdd:cd15954   166 AN-IRVDAIYGLMVALLIGGFDILCIsVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTF 235
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 24-252 7.41e-33

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 122.32  E-value: 7.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAI-FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLF 102
Cdd:cd15948     1 HPWISIpFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILS-IFWFNSREINFNACLVQMF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 103 LHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRG 182
Cdd:cd15948    80 FLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHM 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 183 QLLKLSCNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGY 252
Cdd:cd15948   160 AVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFY 229
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 40-289 1.55e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 115.86  E-value: 1.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  40 GNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSLLGAMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 120 VDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVvdnFFCDRGQLLKLSCNntifiEFIL 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNV---TVCFIDFPEDLSKP-----VSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 200 FLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGR-------RKAFSTCASHFTCVIIGYGCCLFLYVKP------KQTQ 266
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDslaldcELSR 232

                         250       260
                  ....*....|....*....|...
gi 1195726176 267 AADYNRVVSLMISIVTPFLKPFI 289
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPII 255
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 30-257 4.53e-27

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 107.16  E-value: 4.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15955     7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKML-AIFWFQLREISFNACLAQMFFIHTLQA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFG-FLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLS 188
Cdd:cd15955    86 FESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAvVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLA 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1195726176 189 CNNTIFIEFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCCLF 257
Cdd:cd15955   166 ADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFF 234
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 26-294 5.83e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 87.73  E-value: 5.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLHL 105
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGR-WWFGDALCKLLGFLQS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLL 185
Cdd:cd00637    80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 186 KLSCNNTIFIeFILFLMAVFVLFGSLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCVIIGYGCC--------LF 257
Cdd:cd00637   160 AYTIFLFVLL-FLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCwlpyfillLL 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195726176 258 LYVKPKQTQAADYNRVVSLMISIVTPFLKPFIFTLRN 294
Cdd:cd00637   239 DVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 25-160 6.29e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.59  E-value: 6.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLL-GYWPFGPVLCRFWIALD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd14967    80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPL 135
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 25-161 3.01e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 62.99  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVT-LVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFL 103
Cdd:cd14969     1 YVLAVYLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLS-GRWSFGDPGCVIYGFA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYsVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd14969    80 VTFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLF 136
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 35-160 9.97e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 58.42  E-value: 9.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP-VMLSGLLLPgmqsISLAGC--VAQLFLHLALGTTe 111
Cdd:cd14968    12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPlAILISLGLP----TNFHGClfMACLVLVLTQSSI- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 112 FSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd14968    87 FSLL-AIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPM 134
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 25-160 1.95e-09

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 57.24  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15321     8 AIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELM-GYWYFRKTWCEIYLALD 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15321    87 VLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPL 142
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 29-168 3.28e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 56.84  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFY----LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGL-------------LLPGMQS 91
Cdd:cd14993     2 VLIVLYvvvfLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENvyrpwvfgevlckAVPYLQG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176  92 ISLAGCVaqlflhlalgtteFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI-WPVYATFHLNY 168
Cdd:cd14993    82 VSVSASV-------------LTLV-AISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLpLLVVYELEEII 145
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
 35-153 5.43e-09

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 56.00  E-value: 5.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15308    12 LAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFN 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGF 153
Cdd:cd15308    92 LCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSF 130
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 28-160 5.79e-09

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 56.07  E-value: 5.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd15959     5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGAT-ILLTGHWPLGTTVCELWTSVDVLC 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15959    84 VTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPI 136
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 37-150 1.18e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 55.22  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  37 TLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSLLG 116
Cdd:cd15306    14 TIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLC 93

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1195726176 117 AMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15306    94 AISLDRYIAIKKPIQASQYNSRATAFIKITVVWL 127
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 25-154 1.42e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 54.81  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpgmqSISLAG---CVAQL 101
Cdd:cd15063     2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVL----DVWIFGhtwCQIWL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 102 FLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15063    78 AVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 29-154 1.57e-08

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 54.66  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALG 108
Cdd:cd15053     6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 109 TTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15053    86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAA 131
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 35-155 1.76e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 54.67  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsglllpgMQSISLAGCVAQLF------LHLALG 108
Cdd:cd15312    12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSM-------VRSVESCWYFGDLFckihssLDMMLS 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 109 TTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15312    85 TTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLF 131
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
 26-160 2.02e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 54.17  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHL 105
Cdd:cd15323     3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELM-GYWYFGQVWCNIYLALDV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195726176 106 ALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15323    82 LFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL 136
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 35-160 2.53e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 54.17  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvmLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15068    12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQSSIFSL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 115 LgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15068    90 L-AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPM 134
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 28-155 2.94e-08

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 53.83  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd14997     5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFMCKLVPFVELTV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd14997    85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLT 132
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 25-161 3.40e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 53.71  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVttvivpvmlsGLLLPGMQSISLAG-------- 96
Cdd:cd15055     2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLV----------GLLVMPFSMIRSIEtcwyfgdt 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195726176  97 -CVAQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15055    72 fCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLY 137
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 35-133 3.47e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 53.76  E-value: 3.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15305    12 ILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMH 91

                          90
                  ....*....|....*....
gi 1195726176 115 LGAMAVDRYVAVCNPLRYS 133
Cdd:cd15305    92 LCAISLDRYVAIRNPIEHS 110
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 22-163 3.87e-08

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 53.66  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  22 LRHVLFAIFcffYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQL 101
Cdd:cd15979     2 VRILLYSVI---FLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 102 FLHLALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI-WPVYAT 163
Cdd:cd15979    79 LMGVSVSVSTFSLV-AIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIpYPVYSV 140
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 35-140 5.18e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 53.01  E-value: 5.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15304    12 ILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMH 91

                          90       100
                  ....*....|....*....|....*.
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSViMNSHT 140
Cdd:cd15304    92 LCAISLDRYIAIRNPIHHSR-FNSRT 116
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 35-133 9.00e-08

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 52.32  E-value: 9.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15052    12 IATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMH 91

                          90
                  ....*....|....*....
gi 1195726176 115 LGAMAVDRYVAVCNPLRYS 133
Cdd:cd15052    92 LCTISLDRYMAIRYPLRTR 110
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 29-151 1.17e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 52.11  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLLLPGMQSISLAGCVAQLF 102
Cdd:cd15103     6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaleTIVIILLNNGYLVPRDSFEQHIDNVIDSM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 103 LHLALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF 151
Cdd:cd15103    86 ICSSLLASICSLL-AIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVF 133
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 29-154 1.47e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 51.99  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQ-SPMYFFLVHLSILEILVTtVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd15104     5 ILAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVG-LAIPGLATDELLSDGENTQKVLCLLRMCFVITS 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15104    84 CAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGL 130
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 36-159 1.69e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 51.86  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  36 VTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSglllpgmqsISLAGCV-------AQLFLHLALG 108
Cdd:cd15069    13 LSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAIT---------ISLGFCTdfhsclfLACFVLVLTQ 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 109 TTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWP 159
Cdd:cd15069    84 SSIFSLL-AVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTP 133
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 33-160 1.69e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 51.45  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  33 FYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEF 112
Cdd:cd15327    10 FILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVL-GFWAFGRVFCDIWAAVDVLCCTASI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195726176 113 SLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15327    89 LSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL 136
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 29-164 1.70e-07

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 51.79  E-value: 1.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALG 108
Cdd:cd15978     6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 109 TTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI-WPVYATF 164
Cdd:cd15978    86 VSTFNLV-AISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLpYPIYSNL 141
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 25-165 1.83e-07

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 51.19  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15059     2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELM-GYWYFGSVWCEIWLALD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15059    81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKD 141
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 35-161 1.99e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 51.69  E-value: 1.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15005    12 CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFT 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15005    92 LFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVF 138
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 35-160 3.26e-07

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 50.71  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15322    12 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKVWCEIYLALDVLFCTSSIVH 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15322    91 LCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL 136
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 35-228 3.38e-07

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 50.74  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15001    11 VLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPT-WSLGAFLCKAVAYLQLLSFICSVLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDNFFCDRGQLLKLscnntif 194
Cdd:cd15001    90 LTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPSTL------- 162

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1195726176 195 IEFILFLMAVFVLFgsLIPTIV-SYTYIIATILKI 228
Cdd:cd15001   163 YSRLYVVYLAIVIF--FIPLIVmTFAYARDTRKQV 195
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 25-160 3.39e-07

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 50.79  E-value: 3.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvmLSGLL-LPGMQSISLAGCVAQLFL 103
Cdd:cd15051     2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLP--FSAIYeLRGEWPLGPVFCNIYISL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15051    80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPI 136
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 25-161 4.95e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 50.28  E-value: 4.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15325     2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEIL-GYWAFGRVFCNIWAAVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15325    81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLF 137
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 25-239 6.57e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 49.94  E-value: 6.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFfylvTLVGNTVIIVIVCvDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd14978     6 VLPVICIF----GIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTeFS-----LLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIwpvyATFHLNYCKSNVVDNFFC 179
Cdd:cd14978    81 YPLANT-FQtasvwLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNL----PRFFEYEVVECENCNNNS 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 180 DRGQLLKLSCNNTIFIEFILFLMAVFVLFgsLIPTIVSYTYIIATILKIPSASGRRKAFS 239
Cdd:cd14978   156 YYYVIPTLLRQNETYLLKYYFWLYAIFVV--LLPFILLLILNILLIRALRKSKKRRRLLR 213
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 29-150 6.66e-07

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 49.89  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLLLPGMQSISLAGCVAQLF 102
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvsnsleTIMIAVLNSGYLVISDQFIQHMDNVFDSM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195726176 103 LHLALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15352    86 ICISLVASICNLL-AIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 25-157 6.73e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 49.54  E-value: 6.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTV-IVPVMLSGLLLPGMQSISLagCVAQLFL 103
Cdd:cd15196     2 VEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDITYRFYGGDLL--CRLVKYL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRySVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15196    80 QVVGMYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSI 132
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 25-225 6.76e-07

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 49.74  E-value: 6.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAgCVAQLFLH 104
Cdd:cd14992     2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFL-CKIVNYLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY-ATFHLNYCKSNVVDNFFCdrgQ 183
Cdd:cd14992    81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYyATTEVLFSVKNQEKIFCC---Q 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVLfgSLIPTIVSYTYIIATI 225
Cdd:cd14992   158 IPPVDNKTYEKVYFLLIFVVIFVL--PLIVMTLAYARISREL 197
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
 25-161 6.90e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 49.58  E-value: 6.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15329     2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELS-GYWPFGEILCDVWISFD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15329    81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLF 137
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 25-154 7.75e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.70  E-value: 7.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15206     2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15206    82 VSVSVSTFTLV-AISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFL 130
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 35-165 7.86e-07

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 49.48  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15324    12 LVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGSTWCAFYLALDVLFCTSSIVH 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15324    91 LCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKH 141
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 35-160 1.40e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.99  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15058    12 LAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVP-LGATIVVTGKWQLGNFWCELWTSVDVLCVTASIET 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15058    91 LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPI 136
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 33-161 2.11e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 48.35  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  33 FYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMlSGLLLPGMQSISLAGCVAQLFLHLALGTTEF 112
Cdd:cd15326    10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFS-ATLEILGYWVFGRIFCDIWAAVDVLCCTASI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 113 SLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15326    89 LSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL 137
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
 28-227 2.26e-06

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 48.16  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPV----------MLSGLLLPGMQSISLAGC 97
Cdd:cd15195     5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMdavwnytvewLAGDLMCRVMMFLKQFGM 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  98 VAQLFlhlalgttefsLLGAMAVDRYVAVCNPLrySVIMNSHTCNSVVIVSWVFGFLFQIwPVYATFHLNYCKSNVVDNF 177
Cdd:cd15195    85 YLSSF-----------MLVVIALDRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSI-PQSFIFSVLRKMPEQPGFH 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 178 FCDRGQLLKLSCNNTIFIEFILFLMavFVLfgSLIPTIVSYTYIIATILK 227
Cdd:cd15195   151 QCVDFGSAPTKKQERLYYFFTMILS--FVI--PLIITVTCYLLILFEISK 196
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
 30-153 2.34e-06

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 48.04  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  30 FCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGT 109
Cdd:cd15310     7 YCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 110 TEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSV---VIVSWVFGF 153
Cdd:cd15310    87 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVslmITAVWVLAF 133
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 29-160 2.89e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 47.67  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAgCVAQLFLHLALG 108
Cdd:cd14972     4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATW-LLRKGSLVLSLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 109 TTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd14972    83 ASAYSLL-AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPV 133
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 35-161 3.02e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 47.71  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15083    12 LIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFS-GRWIFGKTGCDMYGFSGGLFGIMSINT 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15083    91 LAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLF 137
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
 25-151 3.68e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 47.60  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15401     2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF 151
Cdd:cd15401    82 LSVIGSVFNIT-AIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVL 127
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 35-221 4.17e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 47.42  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15073    12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYP-FSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSViMNSHTCNSVVIVSWVFGFLFQIWPV--YATFHLNYCKSNVVDNFfcdrgqllklSCNNT 192
Cdd:cd15073    91 LTVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAAMPLvgWASYALDPTGATCTINW----------RKNDS 159

                         170       180
                  ....*....|....*....|....*....
gi 1195726176 193 IFIEFIlflMAVFVLFGSLIPTIVSYTYI 221
Cdd:cd15073   160 SFVSYT---MSVIVVNFIVPLAVMFYCYY 185
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
 24-161 4.33e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.64  E-value: 4.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFL 103
Cdd:cd15217     1 YVKLVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15217    81 AVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVF 138
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 26-206 4.38e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 47.24  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvmlsglllPGMqSISLAGC--VAQLF- 102
Cdd:cd15314     3 LYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMP--------PSM-VRSVETCwyFGDLFc 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 103 -----LHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVDnf 177
Cdd:cd15314    74 kihssFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVA-- 151

                         170       180
                  ....*....|....*....|....*....
gi 1195726176 178 fCDRGQLLKLSCNNTIFIEFILFLMAVFV 206
Cdd:cd15314   152 -CEGGCLVFFSKVSSVVGSVFSFYIPAVI 179
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 29-150 5.10e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 47.09  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLLLPGMQSISLAGCVAQLF 102
Cdd:cd15351     6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSvsnlieTLFMLLLEHGVLVCRAPMLQHMDNVIDTM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195726176 103 LHLALgTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15351    86 ICSSV-VSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL 132
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 24-164 6.39e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 46.99  E-value: 6.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVivpVMLSGLLLPGMQSISLAGCVAQLFL 103
Cdd:cd14986     1 VSRVAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFF---TVLTQIIWEATGEWVAGDVLCRIVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 104 HLALGTTEFS--LLGAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLFQIwPVYATF 164
Cdd:cd14986    78 YLQVVGLFAStyILVSMSLDRYQAIVKPMSSL--KPRKRARLMIVVAWVLSFLFSI-PQLVIF 137
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 25-157 6.93e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 46.69  E-value: 6.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd14971     2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 105 LALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd14971    82 VSMHASIFTLV-AMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 28-165 7.69e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 46.72  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIV-PVMLSGLLlpGMQSISLAGCVAQLFLHLA 106
Cdd:cd15054     5 AFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMpPAMLNALY--GRWVLARDFCPIWYAFDVM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195726176 107 LGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15054    83 CCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWH 141
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 29-221 1.17e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 46.27  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMY-FFLVHLSILEILVTTVIVP----VMLSGLLLPGmqsislAGCVAQLFL 103
Cdd:cd15057     6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPwaavNEVAGYWPFG------SFCDVWVSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH----LNYCKSNVVDNFFC 179
Cdd:cd15057    80 DIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHraddTSEALALYADPCQC 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1195726176 180 DrgqlLKLSCNNTIFIEFILFLMAVFVLfgsliptIVSYTYI 221
Cdd:cd15057   160 D----SSLNRTYAISSSLISFYIPVAIM-------IVTYTRI 190
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 27-157 1.37e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 45.88  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  27 FAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLHLA 106
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDII-WRITVEWRAGDFACKVIRYLQVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 107 LGTTEFSLLGAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15197    83 VTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSI 131
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 31-161 1.48e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 45.92  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  31 CFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP--VMLSGLLLPGMQSISLAGCVAQLFLHLALg 108
Cdd:cd15070     8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPlaIVVSLGVTIHFYSCLFMSCLLVVFTHASI- 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 109 tteFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15070    87 ---MSLL-AIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMF 135
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 32-160 1.85e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 45.34  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  32 FFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPV-MLSGLLlpGMQSISLAGCVAQLFLHLALGTT 110
Cdd:cd15074     9 VIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLaIISAFA--HRWLFGDIGCVFYGFCGFLFGCC 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 111 EFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCnSVVIVSWVFGFLFQIWPV 160
Cdd:cd15074    87 SINTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWLYALFWAVAPL 135
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 29-165 1.86e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 45.42  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLP----GMQsislagcVAQLFLH 104
Cdd:cd15065     5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGywlfGET-------FCNIWIS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 105 LALGTTEFSLLG--AMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15065    78 FDVMCSTASILNlcAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLGWH 140
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
 27-155 1.91e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 45.36  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  27 FAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGC-VAQLFLHL 105
Cdd:cd15390     4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFT-YLLYNDWPFGLFYCkFSNFVAIT 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 106 ALGTTEFSLLgAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15390    83 TVAASVFTLM-AISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLL 129
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
 35-167 1.94e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 45.61  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPvmLSGLLLPGMQSiSLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15071    12 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQT-EFYSCLMVACPVLILTQSSILA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFHLN 167
Cdd:cd15071    89 LLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLN 141
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 25-157 2.02e-05

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 45.30  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIfCFF--YLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSG-------------LLLPGM 89
Cdd:cd15207     1 VLFIV-SYSliFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDniltgwpfgdvmcKLSPLV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176  90 QSISLAGCVaqlflhlalgtteFSLLgAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15207    80 QGVSVAASV-------------FTLV-AIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMI 131
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 28-259 2.48e-05

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 45.22  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKR---LQSPMYFFLVHLSILEILVTTVIVPVMLSGLL-LPGMQSISLAGCVAQLFL 103
Cdd:cd15355     5 AIYLALFVVGTVGNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPVELYNFIwVHHPWAFGDAACRGYYFL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIwPVYATFHLNYCKSNVVDNFFCDR-- 181
Cdd:cd15355    85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAI-PMLFTMGEQNRSGTHPGGLICTPiv 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 182 -GQLLKLSCNNTIFIEFILFLMAVFVLFG------------SLIPTIVSYTYIIATILKIPSASGRRKAFSTCASHFTCV 248
Cdd:cd15355   164 dTSTLKVVIQVNAFLSFLFPMLVISVLNTlianqltvmvnqAEQENQVCTIGGQRTVLSVSMEPGRVQSLRHGVLVLRAV 243

                         250
                  ....*....|.
gi 1195726176 249 IIGYGCCLFLY 259
Cdd:cd15355   244 VIAFVVCWLPY 254
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
 35-164 3.16e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 44.75  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSpmYFFLVHLSILEILVTTVIVPV-MLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFS 113
Cdd:cd15220    11 LTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLgILSSSPFFLGVVFGEAECRVYIFLSVCLVSASIL 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 114 LLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATF 164
Cdd:cd15220    89 TISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWP 139
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 25-165 3.84e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 44.27  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAgCVAQLFLH 104
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHL-CDFWISLD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15061    80 VLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSW 140
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
 28-133 4.05e-05

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 44.41  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQ--SPMYFFLVHLSILEILVTTVIVPVMLSGLL---LPGMQSIslagCVAQLF 102
Cdd:cd15142     5 TIPAVMFIFGVVGNLIAIVVLCKSRKEQkeTTFYTLVCGLAVTDLLGTCLASPVTIATYLkgrWPGGQPL----CEYFSF 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1195726176 103 LHLALGTTEFSLLGAMAVDRYVAVCNPLRYS 133
Cdd:cd15142    81 ILLFFSLSGLSIICAMSIERYLAINHAYFYN 111
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
 28-157 4.24e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 44.37  E-value: 4.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd15358     5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETV 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15358    85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSI 134
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 24-151 4.51e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 44.16  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLLLPGMQSISLAGC 97
Cdd:cd15354     1 VIAAEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnaweTITIYLLNNRHLVIEDAFVRHIDN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195726176  98 VAQLFLHLALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF 151
Cdd:cd15354    81 VFDSLICISVVASMCSLL-AIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTF 133
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 24-151 5.27e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 44.00  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHL-------SILEILVTTVIVPVMLSGLLLPGMQSISLAG 96
Cdd:cd15350     1 VVPEEVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLavsdmlgSLYKTLENILIILADMGYLNRRGPFETKLDD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195726176  97 CVAQLFLHLALGTTeFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF 151
Cdd:cd15350    81 IMDSLFCLSLLGSI-FSIL-AIAADRYITIFHALRYHNIMTMRRTLVILAIIWTF 133
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 34-160 5.61e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.81  E-value: 5.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  34 YLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVmlsGLLLPGMQSISLAGCVAQLFLHLAL--GTTE 111
Cdd:cd15330    11 ILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPM---AALYQVLNKWTLGQVTCDLFIALDVlcCTSS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 112 FSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15330    88 ILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPM 136
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 25-175 6.51e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.04  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTV-IVPVMLSGLLLPGMQSISLAGCVAQLFL 103
Cdd:cd15387     2 VEVTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFqVLPQLIWDITFRFYGPDFLCRLVKYLQV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 104 HLALGTTEFSLLgaMAVDRYVAVCNPLRySVIMNSHTCnsVVIVSWVFGFLFQIwPVYATFHLNYCKSNVVD 175
Cdd:cd15387    82 VGMFASTYMLLL--MSIDRCLAICQPLR-SLHRRSDRV--YVLFSWLLSLVFSI-PQVHIFSLREVGNGVYD 147
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 33-161 6.69e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 43.63  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  33 FYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMlSGLLLPGMQSISLAGCVAQLFLHLALGTTEF 112
Cdd:cd15062    10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFS-ATLEVLGYWAFGRIFCDVWAAVDVLCCTASI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 113 SLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15062    89 MSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL 137
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 29-158 6.96e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 43.74  E-value: 6.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLLLPGMQSISLAGCVAQLF 102
Cdd:cd15353     6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngseTVVITLLNGNDTDAQSFTVNIDNVIDSVI 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 103 LHLALGTTeFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF----GFLFQIW 158
Cdd:cd15353    86 CSSLLASI-CSLL-SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTActvsGVLFIIY 143
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
 25-131 7.22e-05

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 43.80  E-value: 7.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15927     2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKD 81

                          90       100
                  ....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLgAMAVDRYVAVCNPLR 131
Cdd:cd15927    82 TSIGVSVFTLT-ALSADRYFAIVNPMR 107
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
 32-159 7.77e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 43.66  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  32 FFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpgmQSISLAGCVAQLFLHLALGTTE 111
Cdd:cd15301     9 VLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTAL---GYWPLGYEVCDTWLAIDYLASN 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 112 FSLLGAMAV--DRYVAVCNPLRYSVimNSHTCNSVVIVSWVFGFLFQIWP 159
Cdd:cd15301    86 ASVLNLLIIsfDRYFSVTRPLTYRA--RRTTKKAAVMIASAWIISLLLWP 133
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 35-161 8.07e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 43.47  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlpgMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15064    12 LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYEL---TGRWILGQVLCDIWISLDVTCCTASI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 115 --LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15064    89 lhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLF 137
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 25-150 8.19e-05

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 43.63  E-value: 8.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15056     2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAI-ELVNNRWIYGETFCLVRTSLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVC-NPLRYSviMNSHTCNSVVIVSWV 150
Cdd:cd15056    81 VLLTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV 125
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 35-132 8.66e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 43.40  E-value: 8.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15307    12 LGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVK-GHFPLSSEHCLTWICLDVLFCTASIMH 90

                          90
                  ....*....|....*...
gi 1195726176 115 LGAMAVDRYVAVCNPLRY 132
Cdd:cd15307    91 LCTISVDRYLSLRYPMRF 108
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 25-155 8.83e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 43.36  E-value: 8.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPV-MLSGL------------LLPGMQS 91
Cdd:cd15203     2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFtLIYTLtknwpfgsilckLVPSLQG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1195726176  92 ISLagCVaqlflhlalgtTEFSLLgAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15203    82 VSI--FV-----------STLTLT-AIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLL 129
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 25-151 9.61e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 43.20  E-value: 9.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsgllLPGMQSISLAG---CVAQL 101
Cdd:cd15317     2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSM----IRTVETCWYFGdlfCKFHT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 102 FLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVF 151
Cdd:cd15317    78 GLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 31-165 1.18e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 43.07  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  31 CFFYLV---TLVGNTVIIVIVCVDKRLQSPMY-FFLVHLSILEILVTTVIVP----VMLSGLLLPGmqsislAGCVAQLF 102
Cdd:cd15320     6 CFLSVLilsTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwkavAEIAGFWPFG------SFCNIWVA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 103 LHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVYATFH 165
Cdd:cd15320    80 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWH 142
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 26-154 1.25e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 42.97  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHL 105
Cdd:cd15402     3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 106 ALGTTEFSLLGaMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15402    83 SVIGSIFNITG-IAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVA 130
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
 25-161 1.46e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 42.84  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFylvTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEiLVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15075     5 IIMAVFSIA---SVVLNATVIIVTLRHKQLRQPLNYALVNLAVAD-LGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIvSWVFGFLFQIWPVY 161
Cdd:cd15075    81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIAS-SWLWSLIWNTPPLF 136
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
 35-155 1.60e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 42.37  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILV-TTVIVPVMLSGLLLPGMQSISLAGCVAQLFL-HLALGTTEF 112
Cdd:cd14995    12 GVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVlVAAGLPNEIESLLGPDSWIYGYAGCLLITYLqYLGINASSL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195726176 113 SLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd14995    92 SIT-AFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLY 133
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 25-131 1.71e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.49  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGC-VAQLFL 103
Cdd:cd15202     2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVN-NTWIFGLFMChFSNFAQ 80

                          90       100
                  ....*....|....*....|....*...
gi 1195726176 104 HLALGTTEFSLLgAMAVDRYVAVCNPLR 131
Cdd:cd15202    81 YCSVHVSAYTLT-AIAVDRYQAIMHPLK 107
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 28-157 1.74e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 42.73  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd14979     5 AIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEAC 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd14979    85 TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 25-150 1.76e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 42.43  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMqSISLAGCVAQLFLH 104
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSW-PFGEVLCRMYQFVH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15012    80 SLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL 125
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
 31-150 1.82e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 42.41  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  31 CFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGmQSISLAGCVAQLFLHLA-LGT 109
Cdd:cd14977     8 LVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKD-WLFGDVMCKLVPFIQVTsLGV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195726176 110 TEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd14977    87 TVFSLC-ALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWV 126
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
 26-147 1.89e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 42.46  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  26 LFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHL 105
Cdd:cd15209     3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195726176 106 ALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNS-HTCNSVVIV 147
Cdd:cd15209    83 SVIGSIFNIT-AIAINRYCYICHSLQYDRLYSLrNTCCYLCLT 124
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 29-154 2.02e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 42.35  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH-LAL 107
Cdd:cd15392     6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYWPFGEFMCPVVNYLQaVSV 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 108 GTTEFSLLgAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15392    86 FVSAFTLV-AISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALA 129
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 35-157 2.13e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 42.03  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15050    12 LITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIV-YLLESKWILGRPVCLFWLSMDYVASTASIFS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15050    91 LFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVI 133
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
 28-157 2.33e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 42.01  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFY----LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP-----VMLSGLLLPGMQSiSLAGCV 98
Cdd:cd15393     1 VLLSILYgiisLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPfqfqaALLQRWVLPRFMC-PFCPFV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195726176  99 AQLFLHLALGTtefslLGAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15393    80 QVLSVNVSVFT-----LTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVAL 131
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 25-131 2.63e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.09  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFcffyLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTV-IVPVMLSGLLLPGMQSISLagCVAQLFL 103
Cdd:cd15386     6 VLAAIL----VVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPQLIWEITYRFQGPDLL--CRAVKYL 79

                          90       100
                  ....*....|....*....|....*...
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLR 131
Cdd:cd15386    80 QVLSMFASTYMLIMMTVDRYIAVCHPLR 107
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
 35-157 3.83e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 41.24  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSP--MYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEF 112
Cdd:cd15002    11 LLGFAGNLMVIGILLNNARKGKPslIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSF 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195726176 113 sLLGAMAVDRYVAVCNPLRySVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15002    91 -TIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPL 133
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
 35-160 4.30e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 41.43  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP----VMLSGLLLPGMQSISLAGCVAQLFLhlalgTT 110
Cdd:cd15958    12 LLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPfgatLVVRGRWLYGSFFCELWTSVDVLCV-----TA 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 111 EFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15958    87 SIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPI 136
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
 25-155 6.19e-04

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 40.78  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLP----GMQSISLAGCVAQ 100
Cdd:cd15389     2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNStwvfGKIMCHLSRFAQY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195726176 101 LFLHLALGTtefslLGAMAVDRYVAVCNPLRYSviMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15389    82 CSVYVSTLT-----LTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCL 129
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 24-236 6.47e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 40.71  E-value: 6.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  24 HVLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTViVPVMLSGLLLPGMQSISLAGCVAQLFL 103
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGGWWPFGDFLCRLTGLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 104 HLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIwPVYATFHLNYCKSNVVDNFFcDRGQ 183
Cdd:cd14982    80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV-PLLLLRSTIAKENNSTTCFE-FLSE 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 184 LLKLSCNNTIFIEFILFLMAVFVlfgslipTIVSYTYIIATILKIPSASGRRK 236
Cdd:cd14982   158 WLASAAPIVLIALVVGFLIPLLI-------ILVCYSLIIRALRRRSKQSQKSV 203
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
 35-295 6.62e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 40.42  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTViVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15072    12 LVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLN-ALVAASSSLL-RRWPYGSEGCQAHGFQGFFTALASICS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSvimnSHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSNVVdnffCDrgqlLKLSCNNTIF 194
Cdd:cd15072    90 SAAIAWDRYHHYCTRSKLQ----WSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTC----CT----LDYSKGDRNY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 195 IEFiLFLMAVFVLFGSLIPTIVSYTYIIATILKipsaSGRRKaFSTCASHFTCVII--GYGCCLFLYVKPKQTQAADYNR 272
Cdd:cd15072   158 VSY-LFTMAFFNFILPLFILLTSYSSIEQKLKK----EGHLR-FNTGLPLLTLLICwgPYAILALYAAITDVTSISPKLR 231

                         250       260
                  ....*....|....*....|...
gi 1195726176 273 VVSLMISIVTPFLKPFIFTLRND 295
Cdd:cd15072   232 MVPALLAKTSPTINAILYALGNE 254
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 35-208 7.35e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 40.49  E-value: 7.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15394    12 LVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVYVSVFT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMnsHTCNSVVIVSWVFGFLFQIWPVYATFHLNYCKSN--VVDNFFCDRGQLLKLSCNNT 192
Cdd:cd15394    92 LTAIAVDRYYVTVYPLRRRISR--RTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDfsICEEFWFGQEKQRLAYACST 169

                         170
                  ....*....|....*.
gi 1195726176 193 IFIEFILFLMAVFVLF 208
Cdd:cd15394   170 LLITYVLPLLAISLSY 185
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 28-225 7.54e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 40.39  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd15134     5 IIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI-WPVYA-TFHLNY---CKSNVVDNFFCdrg 182
Cdd:cd15134    85 SYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpFAIQTrIVYLEYpptSGEALEESAFC--- 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195726176 183 qllklSCNNTIFIEFILFLMAVFVLF-GSLIPTIVSYTYIIATI 225
Cdd:cd15134   162 -----AMLNEIPPITPVFQLSTFLFFiIPMIAIIVLYVLIGLQL 200
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
 25-155 8.17e-04

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 40.53  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsglllpgMQSIS---LAG---CV 98
Cdd:cd15205     2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTL-------LQNISsnwLGGafmCK 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176  99 AQLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15205    75 MVPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIV 131
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
 28-157 8.75e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 40.53  E-value: 8.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLL---LPGMQSIslagCVAQLFLH 104
Cdd:cd15388     5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDItdrFRGPDVL----CRLVKYLQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLrYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15388    81 VVGMFASSYMIVAMTFDRHQAICRPM-VTFQKGRARWNGPVCVAWAISLILSL 132
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
 35-161 1.36e-03

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 39.52  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLlpgMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15335    12 ILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIV---MDTWTLGYFICEIWLSVDMTCCTCSI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 115 LG--AMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15335    89 LHlcVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF 137
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
 25-131 1.44e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 39.75  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFcffyLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15212     6 VLLAIF----LLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDRLCLANGFFN 81

                          90       100
                  ....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLR 131
Cdd:cd15212    82 ACFGIVSTLTMTLISFDRYYAIVRQPQ 108
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
 25-154 1.64e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 39.59  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15048     2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLT-GKWPFGKVFCKAWLVVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15048    81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFL 130
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
 32-160 1.78e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 39.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  32 FFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTE 111
Cdd:cd15218     9 FIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 112 FSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15218    89 AFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPV 137
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 25-150 1.84e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 39.26  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15067     1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15067    81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
 25-154 1.85e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 39.42  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15295     2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIP-YTLTNRWDFGRGLCVFWLVID 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSvimNSHTCNSVVIV----SWVFGFL 154
Cdd:cd15295    81 YLLCTASVYNIVLISYDRYQSVSNAVSYR---NQQTATLRIVTqmvaVWVLAFL 131
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
 29-165 1.87e-03

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 39.34  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP------VMLSGLLLPGMQSISLAGCVAQLF 102
Cdd:cd15384     6 VLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPseaiwaYTVAWLAGNTMCKLVKYLQVFGLY 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195726176 103 LHLalgttefSLLGAMAVDRYVAVCNPLRYSVImnSHTCNSVVIVSWVFGFLFQIwPVYATFH 165
Cdd:cd15384    86 LST-------YITVLISLDRCVAILYPMKRNQA--PERVRRMVTVAWILSPIFSI-PQAVIFH 138
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-157 2.13e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 39.16  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLF-AIFCFFYLVTLVGNTVIIVIVCVDKRLQSP---MYFFLVHLSILEILVTTVIVPVML-SGLLLPGMQSISLAGCVA 99
Cdd:cd15130     1 VLVtAIYLALFVVGTVGNSVTLFTLARKKSLQSLqstVRYHLGSLALSDLLILLLAMPVELyNFIWVHHPWAFGDAGCRG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176 100 QLFLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQI 157
Cdd:cd15130    81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAI 138
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 25-154 2.21e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 39.20  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTvIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd14970     2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLL-GYWPFGEVMCKIVLSVD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd14970    80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLV 129
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
 36-212 2.46e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 39.01  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  36 VTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT----TVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTte 111
Cdd:cd15082    26 LSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSltggTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWS-- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 112 fslLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVsWVFGFLFQIWPV-----YATFHL-NYCKSNVVDNFFCDRGQLL 185
Cdd:cd15082   104 ---LAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WTFSFIWTIPPVlgwssYTVSKIgTTCEPNWYSGNMHDHTYII 179

                         170       180
                  ....*....|....*....|....*...
gi 1195726176 186 klscnnTIFIE-FILFLMAVFVLFGSLI 212
Cdd:cd15082   180 ------TFFTTcFILPLGVIFVSYGKLL 201
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
 25-151 2.74e-03

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 38.71  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15980     2 VFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 LALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNshTCNSVVIVSWVF 151
Cdd:cd15980    82 ISVSASVFTLV-AIAVDRFRCIVYPFKQKLTIS--TAVVIIVIIWVL 125
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 28-150 2.78e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 38.94  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQ--SPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHL 105
Cdd:cd15098     5 VVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195726176 106 ALGTTEFSLLgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWV 150
Cdd:cd15098    85 SMLVSIFTLV-AMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWV 128
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 28-154 2.95e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 38.63  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVI----------VPVMLSGLLLPGMQSISlAGC 97
Cdd:cd15132     5 IVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLpfdlyrlwksRPWIFGEFLCRLYHYIS-EGC 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176  98 VAQLFLHLAlgttefsllgAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15132    84 TYATILHIT----------ALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALL 130
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
 29-161 3.39e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 38.51  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVP----VMLSGLLLPGMQSISLAGCVAQLFlh 104
Cdd:cd15066     5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTfnasVEITGRWMFGYFMCDVWNSLDVYF-- 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176 105 lalGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15066    83 ---STASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIF 136
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
 25-133 3.61e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 38.18  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFfylvTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLH 104
Cdd:cd15060     6 LLSVIIAF----TIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLL-GKWLFGIHLCQMWLTCD 80

                          90       100
                  ....*....|....*....|....*....
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYS 133
Cdd:cd15060    81 ILCCTASILNLCAIALDRYWAIHDPINYA 109
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 28-161 3.74e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.38  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTV-IIVIVCVDKRLQ-SPMYFFLVHLSILE----ILVTTVIVPVMLSGLLLPGMQSIslagCVAQL 101
Cdd:cd14981     5 APPALMFVFGVLGNLLaLIVLARSSKSHKwSVFYRLVAGLAITDllgiLLTSPVVLAVYASNFEWDGGQPL----CDYFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 102 FLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd14981    81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
 29-153 3.80e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 38.09  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSgLLLPGMQSISLAGCVAQLFLHLALG 108
Cdd:cd15309     6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVY-LEVVGEWRFSRIHCDIFVTLDVMMC 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 109 TTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVI-VSWVFGF 153
Cdd:cd15309    85 TASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIsVVWVLSF 130
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-157 4.06e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 38.52  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVT------TVIVPVMLSGLL-------LPGMQS 91
Cdd:cd15208     2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIiiclpaTLLVDVTETWFFgqvlckiIPYLQT 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1195726176  92 ISLAGCVAQLflhlalgttefsllGAMAVDRYVAVCNPLRYSvimNSHTCNSVVIVS-WVFGFLFQI 157
Cdd:cd15208    82 VSVSVSVLTL--------------SCIALDRWYAICHPLMFK---STAKRARVSILIiWIVSLLIMI 131
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
 25-207 4.09e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 38.30  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLsgllLPGMQSISLAG---CVAQL 101
Cdd:cd15316     2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFST----VRSVESCWYFGesfCTFHT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176 102 FLHLALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFgflfqiwPVYATFHLNYCKSN------VVD 175
Cdd:cd15316    78 CCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIF-------SLTYSFSVFYTGVNddgleeLVN 150

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1195726176 176 NFFCDRGQLLKLScNNTIFIEFILFLMAVFVL 207
Cdd:cd15316   151 ALNCVGGCQIILN-QNWVLVDFLLFFIPTFAM 181
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
 32-155 4.69e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 38.01  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  32 FFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEiLVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLALGTTE 111
Cdd:cd15299    12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACAD-LIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNAS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195726176 112 FSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15299    91 VMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVL 134
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 28-155 4.81e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 38.28  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLPGMQSISLAGCVAQLFLHLAL 107
Cdd:cd15133     5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFLLGSGGCYFKTFLFETV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195726176 108 GTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15133    85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLC 132
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 28-154 4.95e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 37.85  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILvTTVIVPVMLSGLLLPgmQSISLAGCVAQLFLHLAL 107
Cdd:cd15928     5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYRLWRY--RPWRFGDLLCRLMYFFSE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195726176 108 GTTEFSLL--GAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFL 154
Cdd:cd15928    82 TCTYASILhiTALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
 29-155 6.30e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 37.84  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  29 IFCFFYLVTLV----GNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTtVIVPVMLSGLLLPGMQSISLAGCVAQLFLH 104
Cdd:cd15365     2 LFPFVYIFVIVisipSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYI-VILPLWIDYLWNGDNWTLSGFVCIFSAFLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195726176 105 LALGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15365    81 YTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICF 131
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
 34-161 6.37e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 37.86  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  34 YLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVpvmLSGLLLPGMQSISLAGCVAQLFLHL----ALGT 109
Cdd:cd15198    11 LVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTA---LSQIIWELLGDRWMAGDVACRLLKLlqasARGA 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195726176 110 TEfSLLGAMAVDRYVAVCNPLRYSVimnshTCNSVVIVSWVFGFLFQIWPVY 161
Cdd:cd15198    88 SA-NLVVLLALDRHQAIRAPLGQPL-----RAWKLAALGWLLALLLALPQAY 133
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
 25-131 6.97e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 37.63  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  25 VLFAIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIvPVMLSGLLlpgMQSISLAGCVAQLFLH 104
Cdd:cd15091     2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYL---MNSWPFGDVLCKIVIS 77

                          90       100
                  ....*....|....*....|....*....
gi 1195726176 105 LALGT--TEFSLLGAMAVDRYVAVCNPLR 131
Cdd:cd15091    78 IDYYNmfTSIFTLTMMSVDRYIAVCHPVK 106
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
 36-155 8.16e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 37.44  E-value: 8.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  36 VTLVGNTVIIVIVC--VDKRLQSPMyFFLVHLSILEILVTTVIVPVMLSGLLlPGMQSISLAGCVAQLFLHLALGTTEFS 113
Cdd:cd15219    12 VSLLSNLLVLLCFLysAELRKQVPG-IFLLNLSFCNLLLTVLNMPFTLLGVV-RNRQPFGDGFCQAVGFLETFLTSNAML 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195726176 114 LLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLF 155
Cdd:cd15219    90 SMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTF 131
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 28-161 8.69e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 37.15  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  28 AIFCFFYLVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLS----GLLLPGMQSISLAGCVAQLfl 103
Cdd:cd15084    15 VLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSnnivGFFVFGKTMCEFEGFMVSL-- 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195726176 104 hlaLGTTEFSLLGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIvSWVFGFLFQIWPVY 161
Cdd:cd15084    93 ---TGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAF-TWGWSLLWTSPPLF 146
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
 35-160 9.46e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.15  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195726176  35 LVTLVGNTVIIVIVCVDKRLQSPMYFFLVHLSILEILVTTVIVPVMLSGLLLpGMQSISLAGCVAQLFLHLALGTTEFSL 114
Cdd:cd15957    12 LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILL-KTWTFGNFWCEFWTSIDVLCVTASIET 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195726176 115 LGAMAVDRYVAVCNPLRYSVIMNSHTCNSVVIVSWVFGFLFQIWPV 160
Cdd:cd15957    91 LCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPI 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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