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Conserved domains on  [gi|1195725628|ref|XP_021021209|]
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LOW QUALITY PROTEIN: olfactory receptor 13A1 [Mus caroli]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11607068)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 42-311 2.51e-162

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 453.25  E-value: 2.51e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
 
Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 42-311 2.51e-162

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 453.25  E-value: 2.51e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 46-322 7.90e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 143.80  E-value: 7.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLslYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:pfam13853   1 FCLM--YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLS 205
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 CSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNA 285
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 286 EK--SKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRKFF 322
Cdd:pfam13853 239 PPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 44-166 5.06e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 38.22  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLaITCNPGLHTPMYFFLFNLATMDIICTSSImpkALRGLVSKRNPISYGGC----MAQLY 119
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTL---PFQIYYYILFQWSFGEFackiVSGLY 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 120 FLTWSASseLLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW 166
Cdd:PHA03087  119 YIGFYNS--MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW 163
 
Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 42-311 2.51e-162

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 453.25  E-value: 2.51e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 42-311 2.05e-130

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 372.59  E-value: 2.05e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 42-318 1.84e-116

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 337.51  E-value: 1.84e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 44-318 4.07e-116

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 336.54  E-value: 4.07e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15231     3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15231    83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15231   163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15231   243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 41-318 6.36e-115

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 333.42  E-value: 6.36e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  41 QLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYF 120
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 121 LTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPP 200
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 201 LLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPV 280
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195725628 281 SSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15235   241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 43-311 5.19e-114

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 331.01  E-value: 5.19e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15230     2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15230    82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15230   162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15230   242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 29-315 7.92e-111

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 323.50  E-value: 7.92e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  29 FILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNP 108
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 109 ISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGP 188
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 189 NVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMY 268
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 269 YTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVK 315
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 45-311 1.17e-110

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 322.48  E-value: 1.17e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  45 FFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15227     4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLL 204
Cdd:cd15227    84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 205 SCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYN 284
Cdd:cd15227   164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                         250       260
                  ....*....|....*....|....*..
gi 1195725628 285 AEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15227   244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 43-318 1.85e-110

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 322.24  E-value: 1.85e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15229     2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15229    82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15229   162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15229   242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 28-322 1.72e-109

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 320.47  E-value: 1.72e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  28 EFILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN 107
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 108 PISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCG 187
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 188 PNVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCM 267
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195725628 268 YYTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRKFF 322
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 33-321 1.50e-108

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 317.77  E-value: 1.50e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  33 GFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYG 112
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 113 GCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVIT 192
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 193 HFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAV 272
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195725628 273 FYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRKF 321
Cdd:cd15406   241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 42-311 6.17e-108

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 315.58  E-value: 6.17e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 29-320 2.13e-107

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 314.98  E-value: 2.13e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  29 FILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNP 108
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 109 ISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGP 188
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 189 NVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMY 268
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195725628 269 YTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRK 292
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 44-311 7.65e-107

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 312.63  E-value: 7.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15918     3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15918    83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15918   163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15918   243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 42-320 4.16e-106

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 311.11  E-value: 4.16e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15417   241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 42-320 6.03e-105

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 308.09  E-value: 6.03e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 42-320 1.64e-101

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 299.61  E-value: 1.64e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNS-VMIVLAdAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPV 280
Cdd:cd15419   161 LKLSCSDTFINElVMFVLC-GLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195725628 281 SSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15419   240 AVSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 43-320 7.77e-100

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 295.47  E-value: 7.77e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15409     2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15409    82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15409   162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15409   242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 44-318 1.50e-99

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 294.46  E-value: 1.50e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15421     3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15421    83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15421   163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15421   243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 42-311 1.33e-97

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 289.38  E-value: 1.33e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 43-318 1.68e-96

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 286.78  E-value: 1.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15234    82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15234   162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15234   242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 42-311 2.06e-95

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 283.78  E-value: 2.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15237     1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15237   241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 29-320 3.53e-95

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 283.94  E-value: 3.53e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  29 FILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNP 108
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 109 ISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGP 188
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 189 NVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMY 268
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195725628 269 YTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 42-311 4.11e-95

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 282.97  E-value: 4.11e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 43-320 2.24e-93

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 278.82  E-value: 2.24e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15413     2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15413    82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15413   242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 44-311 5.27e-93

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 277.65  E-value: 5.27e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15915     3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15915    83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKM-RTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15915   163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                         250       260
                  ....*....|....*....|....*....
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15915   243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 43-320 7.37e-92

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 275.06  E-value: 7.37e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15415     2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15415    82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15415   162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15415   242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 43-311 9.77e-92

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 274.10  E-value: 9.77e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15431     2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTgLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15431    82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSS 282
Cdd:cd15431   161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                         250       260
                  ....*....|....*....|....*....
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15431   241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 29-322 1.27e-91

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 275.12  E-value: 1.27e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  29 FILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNP 108
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 109 ISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGP 188
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 189 NVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMY 268
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195725628 269 YTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRKFF 322
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 42-320 1.54e-91

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 274.30  E-value: 1.54e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 44-318 3.72e-91

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 273.12  E-value: 3.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15429   243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 42-320 4.25e-91

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 273.12  E-value: 4.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 44-318 1.10e-90

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 271.89  E-value: 1.10e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15420     3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15420    83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15420   163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15420   243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 42-320 4.81e-90

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 270.39  E-value: 4.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15416   241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 44-311 2.22e-89

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 268.31  E-value: 2.22e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15939     3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15939    83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSiLKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15939   163 LACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSklAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15939   242 PIDKV--VAVFYTIITPMLNPLIYTLRN 267
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 42-318 2.03e-88

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 266.20  E-value: 2.03e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15405     1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15405    81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15405   161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15405   241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 44-318 5.99e-88

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 265.12  E-value: 5.99e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15233     3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15233    83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15233   163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15233   243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 44-311 2.49e-87

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 262.99  E-value: 2.49e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15224     3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15224    83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15224   163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15224   243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 42-320 3.84e-86

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 260.82  E-value: 3.84e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15414   241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 43-318 4.51e-85

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 257.76  E-value: 4.51e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNP-ISYGGCMAQLYFL 121
Cdd:cd15916     2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKvISFGGCVAQLYFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15916    82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15916   162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SYNAEksKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15916   242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 44-318 1.10e-84

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 256.59  E-value: 1.10e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15228     3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15228    83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPvsSY 283
Cdd:cd15228   163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TP 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15228   241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 42-311 3.26e-84

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 255.21  E-value: 3.26e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15226    81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKmRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15226   161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEksKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15226   240 TFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 42-318 1.88e-83

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 253.55  E-value: 1.88e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 45-318 2.78e-83

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 253.15  E-value: 2.78e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  45 FFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15236     4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLL 204
Cdd:cd15236    84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 205 SCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYN 284
Cdd:cd15236   164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195725628 285 AEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15236   244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 42-311 7.94e-83

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 251.59  E-value: 7.94e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15940     1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15940    81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMrTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15940   161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEksKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15940   240 SFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 41-320 8.33e-83

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 252.01  E-value: 8.33e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  41 QLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYF 120
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 121 LTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPP 200
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 201 LLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPV 280
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195725628 281 SSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 44-318 4.69e-82

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 250.04  E-value: 4.69e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15424     3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15424    83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15424   163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15424   243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 44-311 1.45e-81

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 248.44  E-value: 1.45e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15430     3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15430    83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15430   163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15430   243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 44-318 5.83e-81

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 247.29  E-value: 5.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15434     3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15434    83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15434   163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15434   243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 44-318 8.68e-80

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 244.37  E-value: 8.68e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHT-PMYFFLFNLATMDIICTSSIMPKALRGLVSKR-NPISYGGCMAQLYFL 121
Cdd:cd15941     3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15941    83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15941   163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SyNAEKSKLAgVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15941   243 S-QAGAGAPA-VFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 42-311 3.08e-78

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 239.93  E-value: 3.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15936     1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15936    81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSIlKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15936   161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQ 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEksKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15936   240 TFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 44-318 1.93e-77

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 238.15  E-value: 1.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15428     3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15428    83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15428   163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15428   243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 42-318 4.34e-76

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 234.63  E-value: 4.34e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15942     1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15942    81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15942   161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195725628 282 SYNAekSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15942   241 QDPL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 44-311 3.28e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 232.26  E-value: 3.28e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15914     3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15914    83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15914   163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15914   243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 44-311 1.65e-73

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 227.97  E-value: 1.65e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15913     3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15913    83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15913   163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15913   243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 44-311 3.36e-73

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 227.06  E-value: 3.36e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15938     3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15938    83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIissILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15938   163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEksKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15938   240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 44-318 4.07e-73

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 226.98  E-value: 4.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15433     3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15433    83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15433   163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15433   243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 42-311 7.63e-70

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 218.45  E-value: 7.63e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15937     1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSiLKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 282 SYNAEksKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15937   240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 44-311 1.63e-69

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 217.73  E-value: 1.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15946     3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15946    83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSY 283
Cdd:cd15946   163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                         250       260
                  ....*....|....*....|....*...
gi 1195725628 284 NAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15946   243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 42-311 1.36e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 215.40  E-value: 1.36e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGL-HTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYF 120
Cdd:cd15935     1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 121 LTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPP 200
Cdd:cd15935    81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 201 LLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSiLKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPV 280
Cdd:cd15935   161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195725628 281 SSYnaEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15935   240 SSS--SVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 44-318 2.89e-63

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 201.75  E-value: 2.89e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15223     3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15223    83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYIspvsSY 283
Cdd:cd15223   163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL----TY 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 284 NAEKSK------LAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15223   239 RFGKTIppdvhvLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 46-314 3.08e-54

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 178.38  E-value: 3.08e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15950     5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMM-SKAFCSMLAAGVWALCAFNTAIhTGLMTRLSFCGPNVITHFFCEVPPLLLL 204
Cdd:cd15950    85 AVESGVLLAMAFDRYVAICHPLRYSAILtSQVIAQIGLAIVLRALLFMTPL-TCLVTSLPYCGSRVVPHSYCEHMAVVKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 205 SCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYT-AVFYAYISPVSSY 283
Cdd:cd15950   164 ACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIpGLLSIYTQRFGQG 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195725628 284 NAEKSK-LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15950   244 VPPHTQvLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 42-314 1.72e-52

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 174.01  E-value: 1.72e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLslYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15917     3 LSIPFCAM--YLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPL 201
Cdd:cd15917    81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 202 LLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVS 281
Cdd:cd15917   161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 282 SYNAEKSK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15917   241 GHHVPPHVhiLLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 48-314 1.39e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 171.70  E-value: 1.39e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFC--SMLAAGVWALCAFNTAIHtgLMTRLSFCGPNVITHFFCEVPPLLLLS 205
Cdd:cd15221    87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIgkIGVAAVARSFCIVFPFVF--LLKRLPYCGHNVIPHTYCEHMGIARLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 CSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNA 285
Cdd:cd15221   165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHI 244

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195725628 286 EKSK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15221   245 PRHVhiLLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 46-314 8.10e-51

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 169.48  E-value: 8.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15952     5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLS 205
Cdd:cd15952    85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 CSSTYVNSVMIVLADAFYgILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNA 285
Cdd:cd15952   165 CASIRINIIYGLFAISVL-VLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNI 243

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195725628 286 EKSK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15952   244 PRYIhiLLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 44-314 9.24e-49

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 164.21  E-value: 9.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15222     3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15222    83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFyaYISPVSSY 283
Cdd:cd15222   163 LACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMI--GLSMVHRF 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195725628 284 NAEKSKLAGVL----YTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15222   241 GKHASPLVHVLmanvYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 48-314 1.05e-46

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 159.05  E-value: 1.05e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15951     7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLSCS 207
Cdd:cd15951    87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 208 STYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEK 287
Cdd:cd15951   167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPP 246

                         250       260
                  ....*....|....*....|....*....
gi 1195725628 288 SK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15951   247 HVhiLIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 48-314 1.59e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 158.58  E-value: 1.59e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLSCS 207
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 208 STYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEK 287
Cdd:cd15953   167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGIAP 246

                         250       260
                  ....*....|....*....|....*....
gi 1195725628 288 SK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15953   247 HIhiILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 37-315 6.41e-44

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 151.98  E-value: 6.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  37 HPQYQLPlffcFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMA 116
Cdd:cd15948     1 HPWISIP----FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 117 QLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFC 196
Cdd:cd15948    77 QMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 197 EVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYT-AVFYA 275
Cdd:cd15948   157 EHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTpVVLSS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 276 YISPVSSYNAEKSK-LAGVLYTMLSPTLNPLIYTLRNKEVK 315
Cdd:cd15948   237 TMHRFARHVAPHVHiLLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 48-314 7.69e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 148.86  E-value: 7.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15956     7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAfCSMLAAGVWALCAFNTAIHTGLMT-RLSFCGPNVITHFFCEVPPLLLLSC 206
Cdd:cd15956    87 ESGVLVAMALDRFVAICNPLHYATILTLE-VVAKAGLLLALRGVAIVIPFPLLVcRLSFCASHTIAHTYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 207 SSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAE 286
Cdd:cd15956   166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVP 245

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 287 KSK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15956   246 SAAhvLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 46-322 7.90e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 143.80  E-value: 7.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLslYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:pfam13853   1 FCLM--YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLS 205
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 CSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNA 285
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 286 EK--SKLAGVLYTMLSPTLNPLIYTLRNKEVKAALRKFF 322
Cdd:pfam13853 239 PPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 27-315 4.04e-37

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 134.52  E-value: 4.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  27 TEFILQGFSEHPQYQLPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKR 106
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 107 NPISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFC 186
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 187 GPNVITHFFCEVPPLLLLSCSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVC 266
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195725628 267 MYYTAVFYAYISPVSSYNAEKSK--LAGVLYTMLSPTLNPLIYTLRNKEVK 315
Cdd:cd15949   242 AFYVPIAVSSLIHRFGQNVPPPThiLLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 46-314 2.29e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 131.87  E-value: 2.29e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15954     5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLLS 205
Cdd:cd15954    85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 CSSTYVNSVMIVLADAFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPV---SS 282
Cdd:cd15954   165 CANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfggHH 244

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195725628 283 YNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15954   245 ITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 58-307 1.65e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 123.95  E-value: 1.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN-PISYGGCMAQLYFLTWSASSELLLLTVMA 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 137 YDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNvitHFFCEVPPLLLLSCSSTYVNSVMI 216
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 217 VLadafyGILNFLMTIVSYGFIISSILKMRTSEG-------KQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEKSK 289
Cdd:pfam00001 158 LG-----FLLPLLVILVCYTLIIRTLRKSASKQKssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 1195725628 290 ------LAGVLYTMLSPTLNPLIY 307
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 48-314 1.48e-32

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 121.80  E-value: 1.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15955     7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMT-RLSFCGPNVITHFFCEVPPLLLLSC 206
Cdd:cd15955    87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 207 SSTYVNSVM-IVLADAFYGIlNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNA 285
Cdd:cd15955   167 DDVRVNKIYgLFVAFSILGF-DIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHV 245

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195725628 286 EKSK--LAGVLYTMLSPTLNPLIYTLRNKEV 314
Cdd:cd15955   246 APYVhiLLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 44-311 2.19e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 100.06  E-value: 2.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFcevpplll 203
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCW-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 lsCSSTYVNSVMIVLADAFYgILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSH-----------LIVVCM----- 267
Cdd:cd00637   153 --PDLTLSKAYTIFLFVLLF-LLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVfllcw 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1195725628 268 --YYTAVFYAYISPVSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd00637   230 lpYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 44-318 1.04e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 78.37  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd14967     4 VFLSLIIL--VTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWaLCAFNTAIhTGLMTRLSFCGPNVITHFFCEVPplll 203
Cdd:cd14967    82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVW-VYSLLISL-PPLVGWRDETQPSVVDCECEFTP---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 lscSSTYVNSVMIVladAFYgiLNFLMTIVSYGFIISSILKmrtsegKQKAFSTCSshlIVVCM-------YYTAVFYAY 276
Cdd:cd14967   156 ---NKIYVLVSSVI---SFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAfllcwlpFFIIYLVSA 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195725628 277 ISPVSSYNAEKSKLAGVLyTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd14967   219 FCPPDCVPPILYAVFFWL-GYLNSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 48-318 1.27e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 61.07  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVA-LTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd14969     6 YLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTM-MSKAFCSMLAAGVWALcAFNTA--------IHTGLMTRlsfCGPNVITHffce 197
Cdd:cd14969    86 VSISTLAALAFERYLVIVRPLKAFRLsKRRALILIAFIWLYGL-FWALPplfgwssyVPEGGGTS---CSVDWYSK---- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 198 vpplllLSCSSTYVNSVMIvladaFYGILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSS-------HLIVVCMYYT 270
Cdd:cd14969   158 ------DPNSLSYIVSLFV-----FCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkkaekkVAKMVLVMIV 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195725628 271 AVF-----YAYISPVSSYNAEK--SKLAGVLYTML---SPTLNPLIYTLRNKEVKAAL 318
Cdd:cd14969   227 AFLiawtpYAVVSLYVSFGGEStiPPLLATIPALFaksSTIYNPIIYVFMNKQFRRAL 284
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 48-170 1.59e-10

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 60.45  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYC-VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMP-KALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15067     5 VLSLFClVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDVWHSFDVLAS 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15067    85 TASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSA 129
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 43-318 6.06e-10

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 59.20  E-value: 6.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSL-YCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPkaLRGLVS-KRNPISYGG--CMAQL 118
Cdd:cd14982     1 TLFPIVYSLiFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LP--FRIYYYlNGGWWPFGDflCRLTG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 119 YFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCafntAIHTGLMTRLSFCGPNVITHFFCEV 198
Cdd:cd14982    78 LLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILV----LVASVPLLLLRSTIAKENNSTTCFE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 199 PPLLLLSCSSTYVNSVMIVLadafyGILNFLMTIVSYGFIISSILKMRTSEG----KQKAFSTCSSHLIV--VC------ 266
Cdd:cd14982   154 FLSEWLASAAPIVLIALVVG-----FLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVflVCflpyhv 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195725628 267 --MYYTAVFYAYISPVSSYNA-EKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd14982   229 trILYLLVRLSFIADCSARNSlYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 42-168 1.95e-09

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 57.59  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkalrglVSKRNPISYGGCMAQLYFL 121
Cdd:cd15326     1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP------FSATLEILGYWVFGRIFCD 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195725628 122 TWSA------SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15326    75 IWAAvdvlccTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVL 127
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 48-318 2.09e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 57.30  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIIC-TSSIMPKALRGLVSKRNPISygGCMAQLYFLTWSAS 126
Cdd:cd14972     5 AIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAgIAFVFTFLSVLLVSLTPSPA--TWLLRKGSLVLSLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALC-AFNTAIHTGLMTRLSFCgPNVITHFfcevPPLllls 205
Cdd:cd14972    83 ASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSvLLALLPVLGWNCVLCDQ-ESCSPLG----PGL---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 206 cSSTYVNSVMIVLADAFYGILNFLMTIVSYgfiissiLKMRTS------EGKQKAFSTCSSHLIVVCMYYTAVFYAYISP 279
Cdd:cd14972   154 -PKSYLVLILVFFFIALVIIVFLYVRIFWC-------LWRHANaiaarqEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLP 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195725628 280 VS------SYNAEKSKLAGVLYTMLSPTL-----NPLIYTLRNKEVKAAL 318
Cdd:cd14972   226 LLillvldVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 48-168 2.98e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 57.22  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCV----ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKrnPISYGG--CMAQLYFL 121
Cdd:cd14993     3 LIVLYVVvfllALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR--PWVFGEvlCKAVPYLQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd14993    81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI 127
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 42-182 5.44e-09

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 56.57  E-value: 5.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRgLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15134     1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELY-TIWQQYPWVFGEVFCKLRAF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195725628 122 TWSASSELLLLTVMAY--DRYAAICHPLHYSTMMSKAFCSMLAAGVWaLCAFNTAIHTGLMTR 182
Cdd:cd15134    80 LSEMSSYASVLTITAFsvERYLAICHPLRSHTMSKLSRAIRIIIAIW-IIAFVCALPFAIQTR 141
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 48-175 7.00e-09

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 56.24  E-value: 7.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15208     7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLaaGVWALcAFNTAI 175
Cdd:cd15208    87 SVLTLSCIALDRWYAICHPLMFKSTAKRARVSIL--IIWIV-SLLIMI 131
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
 50-166 8.52e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 55.62  E-value: 8.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  50 SLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSEL 129
Cdd:cd15215     8 IFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGV 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195725628 130 LLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW 166
Cdd:cd15215    88 NTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTW 124
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 43-177 8.91e-09

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 55.52  E-value: 8.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFF-CFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPIsYGGCMAQLYFL 121
Cdd:cd15394     1 PLIIpLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWV-FGRFMCYFVFL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195725628 122 TWSAS--SELLLLTVMAYDRYAAICHPLHysTMMSKAFCSMLAAGVWALC---AFNTAIHT 177
Cdd:cd15394    80 MQPVTvyVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLScglALPAAAHT 138
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 48-257 2.06e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 54.67  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnPISYGGCMAQLYFLTWSASS 127
Cdd:cd14979     7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQY-PWAFGDGGCKLYYFLFEACT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLLLTVMAY--DRYAAICHPLHYSTMMSKAFCSMLAAGVWALcAFNTAIHTGLMTRL-SFCGPNVITH---FFCEVPPl 201
Cdd:cd14979    86 YATVLTIVALsvERYVAICHPLKAKTLVTKRRVKRFILAIWLV-SILCAIPILFLMGIqYLNGPLPGPVpdsAVCTLVV- 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195725628 202 lllscSSTYVNSVMIVLADAFYGILNFLMTIVsYGFIISSILKMRTSEGKQKAFST 257
Cdd:cd14979   164 -----DRSTFKYVFQVSTFIFFVLPMFVISIL-YFRIGVKLRSMRNIKKGTRAQGT 213
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 54-318 2.16e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.17  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMP-KALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLL 132
Cdd:cd15304    13 LTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 133 TVMAYDRYAAICHPLHYSTMMS--KAFCSMLAagVWalcafntAIHTGLMTRLSFCGPNVITHFFCEVppllllSCSSTY 210
Cdd:cd15304    93 CAISLDRYIAIRNPIHHSRFNSrtKAFLKIIA--VW-------TISVGISMPIPVFGLQDDSKVFKEG------SCLLAD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 211 VNSVMIVLADAFYgiLNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVV--CMYYTAVFYAYISPVSSYNAEKS 288
Cdd:cd15304   158 ENFVLIGSFVAFF--IPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVmwCPFFITNVMAVICKESCNEVVIG 235

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195725628 289 KLAGVLYTM--LSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15304   236 GLLNVFVWIgyLSSAVNPLVYTLFNKTYRSAF 267
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 53-168 2.95e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 54.39  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  53 CVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDII----CTSSIMPKALRGLVSkrnPISYGGCMAQLYFLTWSASSE 128
Cdd:cd15005    12 CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrslaCFPFVMASVRHGSGW---IYGALSCKVIAFLAVLFCFHS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15005    89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTL 128
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 43-166 5.71e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 53.05  E-value: 5.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15001     1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPlhystMMSKAFCSM-----LAAGVW 166
Cdd:cd15001    81 LSFICSVLTLTAISIERYYVILHP-----MKAKSFCTIgrarkVALLIW 124
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 54-171 1.12e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 52.60  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGC--MAQLYFLTWSASSELLl 131
Cdd:cd15959    13 VIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTASIETL- 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 132 lTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15959    92 -CAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAA 130
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 49-168 1.37e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 52.24  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRglVSKRNPISYGGCMAQLYFLTWSASSE 128
Cdd:cd15069     8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAIT--ISLGFCTDFHSCLFLACFVLVLTQSS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15069    86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVL 125
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 54-184 1.75e-07

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 51.74  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15202    13 FSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLT 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195725628 134 VMAYDRYAAICHPLHYSTmmSKAFCSMLAAGVWALC---AFNTAIHTGLMTRLS 184
Cdd:cd15202    93 AIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLAlafALPHAICSKLETFKY 144
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
 44-167 1.85e-07

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 51.69  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMY-FFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15219     2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLET 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA 167
Cdd:cd15219    82 FLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWL 126
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 58-168 2.09e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 51.43  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkalrglVSKRNPISYGGCMAQLYFLTWSA------SSELLL 131
Cdd:cd15325    17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP------FSAIFEILGYWAFGRVFCNIWAAvdvlccTASIMS 90

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195725628 132 LTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15325    91 LCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVL 127
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 55-168 2.39e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 51.34  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  55 ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkalrglVSKRNPISYGGCMAQLYFLTWSA------SSE 128
Cdd:cd15062    14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP------FSATLEVLGYWAFGRIFCDVWAAvdvlccTAS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15062    88 IMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 48-169 2.54e-07

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 51.09  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICT-SSIMPKALRGLVSKRNPISYGGCMAQL-----YFL 121
Cdd:cd15354     7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdSLI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALC 169
Cdd:cd15354    87 CISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFC 134
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 48-169 2.72e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 50.95  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICT-SSIMPKALRGLVSKRNPISYGGCMAQL-----YFL 121
Cdd:cd15103     7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvSNALETIVIILLNNGYLVPRDSFEQHIdnvidSMI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALC 169
Cdd:cd15103    87 CSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFC 134
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
 54-307 3.02e-07

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 50.91  E-value: 3.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPKALRGLVSKRNPI-SYGGCMAQLYFLTWSASSELLLL 132
Cdd:cd14991    13 LGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLIC-LPFRIDYYLRGEHWIfGEAWCRVNLFMLSVNRSASIAFL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 133 TVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCafntaihtglmtrLSFCGPNVITHFFC-EVPPLLLLSCSSTYV 211
Cdd:cd14991    92 TAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALV-------------LLLTLPLLLSTLLTvNSNKSSCHSFSSYTK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 212 NSVMIVLADAFYgILNFLMT---IVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVF--------YAYISPV 280
Cdd:cd14991   159 PSLSIRWHNALF-LLEFFLPlglIVFCSVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFlpsiiaglLALVFKN 237

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195725628 281 SSYNAEKSKLAGVL-----YTMLSPTLNPLIY 307
Cdd:cd14991   238 LGSCRCLNSVAQLFhislaFTYLNSALDPVIY 269
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 54-171 3.69e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 50.70  E-value: 3.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDII-CTSSIMPKalrgLVSKRNPISYGG---CMAQLYF--LTWSASS 127
Cdd:cd15196    13 LALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLvALFNVLPQ----LIWDITYRFYGGdllCRLVKYLqvVGMYASS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195725628 128 ELLLltVMAYDRYAAICHPLHySTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15196    89 YVLV--ATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLL 129
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 48-219 3.76e-07

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 50.55  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSS------IMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15350     7 FFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktleniLIILADMGYLNRRGPFETKLDDIMDSLF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAihtgLMTRLSFCGPNVIthFFCEVPPL 201
Cdd:cd15350    87 CLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGI----LMILFFHFVATVI--CFTVLFFL 160

                         170
                  ....*....|....*...
gi 1195725628 202 LLLSCSSTYVNsvMIVLA 219
Cdd:cd15350   161 MLVLILCLYVH--MFLLA 176
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 58-321 3.85e-07

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 50.67  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN-PISYGGCMAQLYFLTWSASSELLLLTVMA 136
Cdd:cd15305    17 GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTASIMHLCAIS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 137 YDRYAAICHPLHYSTMMSKAFCSMLAAGVWAlcafntaIHTGLMTRLSFCGPNVITHFFCEVppllllSCSSTYVNSVMI 216
Cdd:cd15305    97 LDRYVAIRNPIEHSRFNSRTKAMMKIAAVWT-------ISIGISMPIPVIGLQDDEKVFVNG------TCVLNDENFVLI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 217 VLADAFYgiLNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEKSKLAGVLYT 296
Cdd:cd15305   164 GSFVAFF--IPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEELLN 241

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195725628 297 M------LSPTLNPLIYTLRNKEVKAALRKF 321
Cdd:cd15305   242 VfvwvgyVSSGINPLVYTLFNKTYRRAFSNY 272
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 54-318 5.65e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 50.33  E-value: 5.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrgLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd14968    13 LSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGCLFMACLVLVLTQSSIFSLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSK-------AFCSMLAAGVWALCAFNTaihTGLMTRLSFCGPNVITHFFCEVPPLLLLsc 206
Cdd:cd14968    91 AIAIDRYLAIKIPLRYKSLVTGrrawgaiAVCWVLSFLVGLTPMFGW---NNGAPLESGCGEGGIQCLFEEVIPMDYM-- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 207 ssTYVNSVMIVLADAFygilnfLMTIVsYGFIISSILK--------MRTSEGK---QKAFSTCSSHLIVVCMY------- 268
Cdd:cd14968   166 --VYFNFFACVLVPLL------IMLVI-YLRIFRVIRKqlrqieslLRSRRSRstlQKEVKAAKSLAIILFLFalcwlpl 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195725628 269 YTAVFYAYISPvSSYNAEKSKLAGVLYTMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd14968   237 HIINCITLFCP-ECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 49-170 5.86e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 50.14  E-value: 5.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVALT-GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGC--MAQLYFLTWSA 125
Cdd:cd15058     7 LALIILAIVvGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDVLCVTA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 126 SSELLllTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15058    87 SIETL--CVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSA 129
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 44-154 6.63e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 49.86  E-value: 6.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCValTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkaLRGLVSKRNPISYGGCMAQLY---- 119
Cdd:cd15055     5 IVLSSISLLTV--LGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP--FSMIRSIETCWYFGDTFCKLHssld 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1195725628 120 -FLTwSASseLLLLTVMAYDRYAAICHPLHYSTMMS 154
Cdd:cd15055    81 yILT-SAS--IFNLVLIAIDRYVAVCDPLLYPTKIT 113
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 47-238 6.76e-07

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 50.12  E-value: 6.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCV-ALTGNVLILLAITCNPGLHTPMY-FFLFNLATMDIICTSSIMPKALRGLVSKRNPisYGG-CMAQLYFLTW 123
Cdd:cd15057     5 CILYLLVLlTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEVAGYWP--FGSfCDVWVSFDIM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIhtGLMTRLSFCGPNVITHFFCEVPPLLL 203
Cdd:cd15057    83 CSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFI--PVQLGWHRADDTSEALALYADPCQCD 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1195725628 204 LSCSSTYVNSVMIVladAFYgILNFLMtIVSYGFI 238
Cdd:cd15057   161 SSLNRTYAISSSLI---SFY-IPVAIM-IVTYTRI 190
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 42-176 6.95e-07

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 49.84  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVskRN---PISYGGCMAQL 118
Cdd:cd15133     1 FPVCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELW--QNypfLLGSGGCYFKT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195725628 119 YFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA---LCAF-NTAIH 176
Cdd:cd15133    79 FLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGvsmLCALpNTSLH 140
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 47-169 7.11e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.70  E-value: 7.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd15206     6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALC 169
Cdd:cd15206    86 VSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLS 128
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 54-183 7.49e-07

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 49.67  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKAL-RGLVSKRNPisYGGCMAQL--YFLTWSASSELL 130
Cdd:cd15392    13 LAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFiALLILQYWP--FGEFMCPVvnYLQAVSVFVSAF 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195725628 131 LLTVMAYDRYAAICHPLhySTMMSKAFCSMLAAGVWALcAFNTAIHTGLMTRL 183
Cdd:cd15392    91 TLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIF-ALATALPIAITSRL 140
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 44-168 8.47e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 49.42  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15063     5 LVLTFLNV--LVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVW 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15063    83 MCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL 127
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 55-196 1.39e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 48.91  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  55 ALTGNVLILLAIT-CNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15104    13 IITGNLLVIVALLkLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW----------------------ALCAFNTAIHTGLMTRLSFCG--PN 189
Cdd:cd15104    93 AIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWlysgligflplispqfqqtsykGKCSFFAAFHPRVLLVLSCMVffPA 172


                  ....*..
gi 1195725628 190 VITHFFC 196
Cdd:cd15104   173 LLLFVFC 179
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 42-168 1.44e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 48.96  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15050     3 LGIALSTISL--ITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15050    81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLL 127
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
 42-187 1.45e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 49.00  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnPISYG--GCMAQLY 119
Cdd:cd15358     1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNY-PFLLGagGCYFKTL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195725628 120 FLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA---LCAF-NTAIHtGLMTRLSFCG 187
Cdd:cd15358    80 LFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVvsiLCSIpNTSLH-GIFQLTVPCR 150
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
 50-168 1.54e-06

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 48.81  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  50 SLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSEL 129
Cdd:cd15297     9 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195725628 130 LLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15297    89 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVL 127
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 47-317 1.54e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 48.51  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd15061     5 FLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALcafntaihTGLMTRLSFCGPNvithffcEVPPLLLLSC 206
Cdd:cd15061    85 ASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVI--------SLLITSPPLVGPS-------WHGRRGLGSC 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 207 SSTYVNSVMIvladaFYGILNFLMTIVSYGFIISSILKMRTSEgkQKAFSTCSshlIVVCMY---YTAVFYAY-ISPVSS 282
Cdd:cd15061   150 YYTYDKGYRI-----YSSMGSFFLPLLLMLFVYLRIFRVIAKE--RKTAKTLA---IVVGCFivcWLPFFIMYlIEPFCD 219

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195725628 283 YNAEKSKLAGVLYT-MLSPTLNPLIYTLRNKEVKAA 317
Cdd:cd15061   220 CQFSEALSTAFTWLgYFNSVINPFIYAFYNKDFRRA 255
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 48-166 2.07e-06

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 48.37  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLY-CVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrglvskrnPISYGGCMA--QLYFLTWS 124
Cdd:cd15327     6 FLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSA--------TLEVLGFWAfgRVFCDIWA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 125 A------SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW 166
Cdd:cd15327    78 AvdvlccTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLW 125
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 46-185 2.23e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 48.56  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15336     5 SVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFG 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGV------WALCAF---NTAIHTGLMTRLSF 185
Cdd:cd15336    85 ITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVwlyslaWSLPPLfgwSAYVPEGLLTSCTW 153
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
 58-171 2.28e-06

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 48.36  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnpISYGGCMAQLY----FLTWSASSELLllT 133
Cdd:cd15958    17 GNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGR--WLYGSFFCELWtsvdVLCVTASIETL--C 92

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15958    93 VIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISAL 130
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 48-168 2.51e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 48.37  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCV----ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPisYGGCMAQL----- 118
Cdd:cd15203     3 LILLYGLiivlGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWP--FGSILCKLvpslq 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195725628 119 ----YFLTWSasselllLTVMAYDRYAAICHPLhySTMMSKAFCSMLAAGVWAL 168
Cdd:cd15203    81 gvsiFVSTLT-------LTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWIL 125
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 44-173 2.70e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 48.21  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15317     3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNT 173
Cdd:cd15317    83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYT 132
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 48-166 3.89e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 47.48  E-value: 3.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLY------FL 121
Cdd:cd15351     7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtMI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW 166
Cdd:cd15351    87 CSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIW 131
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 48-170 4.19e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 47.60  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSS-----IMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15353     7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngsetVVITLLNGNDTDAQSFTVNIDNVIDSVIC 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15353    87 SSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACT 134
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
 46-167 4.57e-06

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 47.45  E-value: 4.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTpmYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLY-----F 120
Cdd:cd15220     4 FCMVLLDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYiflsvC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 121 LTWSAsseLLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA 167
Cdd:cd15220    82 LVSAS---ILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWV 125
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
 54-168 4.64e-06

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 47.25  E-value: 4.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15089    13 VGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETW-PFGELLCKAVLSIDYYNMFTSIFTLT 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15089    92 MMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVL 126
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
 44-168 4.70e-06

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 47.40  E-value: 4.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15393     3 LSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLhySTMMSKAFCSMLAAGVWAL 168
Cdd:cd15393    83 SVNVSVFTLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWIL 125
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 45-170 6.59e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 46.72  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  45 FFCFLSLYCVAltGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15054     6 FLCLIILLTVA--GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMC 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15054    84 CSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAA 129
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 42-147 8.76e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 46.52  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDiICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd14970     3 IPAVYSVVCV--VGLTGNSLVIYVILRYSKMKTVTNIYILNLAVAD-ELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79

                          90       100
                  ....*....|....*....|....*.
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPL 147
Cdd:cd14970    80 AYNMFTSIFCLTVMSVDRYLAVVHPV 105
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 48-169 9.60e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 46.42  E-value: 9.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLY------FL 121
Cdd:cd15352     7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsMI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALC 169
Cdd:cd15352    87 CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVC 134
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 48-171 1.11e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 46.19  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCV-ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd15065     5 FLSLIIVlAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCST 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15065    85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 54-173 1.12e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 46.13  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSkRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd14997    13 VGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWA-REPWLLGEFMCKLVPFVELTVAHASVLT 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195725628 134 VMA--YDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNT 173
Cdd:cd14997    92 ILAisFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTS 133
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 46-222 1.28e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 46.09  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITcNPGLHTPMYFFLFNLATMDII-CTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd14978     5 YVLPVICIFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILvLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 125 A----SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPP 200
Cdd:cd14978    84 AntfqTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                         170       180
                  ....*....|....*....|..
gi 1195725628 201 LLLLSCSSTYVNSVMIVLADAF 222
Cdd:cd14978   164 LRQNETYLLKYYFWLYAIFVVL 185
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
 51-168 1.37e-05

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 46.17  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMD----IICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd15216    10 LLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADglraLACLPAVMLAARRAAAAAGTPPGALGCKLLAFLAALFCF 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFC-SMLAAGVWAL 168
Cdd:cd15216    90 HAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCaAMLVCAAWAL 132
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 45-320 1.48e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 45.71  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  45 FFCFLSLYCVALT--GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15307     2 YWALLALVLVLGTaaGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALcafNTAIHTGLMTRLSFCGPNVITHFFCEVPPLL 202
Cdd:cd15307    82 LFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLL---SIAMSLPLSLMYSKDHASVLVNGTCQIPDPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 203 LlscssTYVNSVMivladAFYgiLNFLMTIVSYGFIISSILKMRTSEGK-----QKAFSTCSSHLIVVCMYYTAVFYAYI 277
Cdd:cd15307   159 Y-----KLVGSIV-----CFY--IPLGVMLLTYCLTVRLLARQRSRHGRiirleQKATKVLGVVFFTFVILWSPFFVLNL 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195725628 278 SPVSSYNAEkSKLAGVLYTML------SPTLNPLIYTLRNKEVKAALRK 320
Cdd:cd15307   227 LPTVCAECE-ERISHWVFDVVtwlgyaSSMVNPIFYTIFNKVFRQAFKK 274
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 47-146 1.69e-05

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 45.69  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPisYGGCMAQLYFL--TWS 124
Cdd:cd15207     6 SYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWP--FGDVMCKLSPLvqGVS 83

                          90       100
                  ....*....|....*....|..
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHP 146
Cdd:cd15207    84 VAASVFTLVAIAVDRYRAVVHP 105
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 54-154 1.71e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 45.81  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrgLVSKRNPISYGGCMAQLYF---LTWSASSeLL 130
Cdd:cd15312    13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSM--VRSVESCWYFGDLFCKIHSsldMMLSTTS-IF 89

                          90       100
                  ....*....|....*....|....
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMS 154
Cdd:cd15312    90 HLCFIAVDRYYAVCDPLHYRTKIT 113
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 54-171 1.71e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.40  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15064    13 ATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLC 92

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15064    93 VIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSIC 130
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 49-238 1.81e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.56  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIIcTSSIMPKALRGLVSKRnPISYGG--CMAQLYFLTWSAS 126
Cdd:cd15928     8 SVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYRLWRYR-PWRFGDllCRLMYFFSETCTY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVPPLlllsc 206
Cdd:cd15928    86 ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNV----- 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1195725628 207 sSTYVNSVMIVLADAFYGILNFLMTIVsYGFI 238
Cdd:cd15928   161 -SSGLLSVMLWVSTSFFFVPMVCLSLL-YGLI 190
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 43-170 2.14e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 45.51  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15012    81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSA 128
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 43-168 2.19e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 45.36  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15096     4 PVIFGLIFI--VGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15096    82 VTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV 127
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
 46-167 2.69e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 45.07  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIIC-TSSIMPKALRGLVSKRNPI-SYGGCMAQLY--FL 121
Cdd:cd14995     5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVlVAAGLPNEIESLLGPDSWIyGYAGCLLITYlqYL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195725628 122 TWSASSelLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA 167
Cdd:cd14995    85 GINASS--LSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWI 128
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 54-200 3.58e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 44.73  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd14992    13 VSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLT 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA---LCAFNTAIHTGLMTRLSFCGPNVIthFFCEVPP 200
Cdd:cd14992    93 AIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVvslLLAIPQLYYATTEVLFSVKNQEKI--FCCQIPP 160
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
 50-168 3.61e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 44.63  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  50 SLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSEL 129
Cdd:cd15298     9 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195725628 130 LLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15298    89 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVL 127
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 44-170 4.20e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN-PISYGGCMAQLYFLT 122
Cdd:cd15053     5 LFLLLLPL--LTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYIAMDV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 123 WSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15053    83 MCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSA 130
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 54-175 5.33e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 44.08  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15318    13 IIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLC 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAFNTAI 175
Cdd:cd15318    93 FISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSV 134
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 54-317 5.66e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 43.84  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKA-LRGLVSKRNPISYGGCMAQLYFLTWSASSELLLL 132
Cdd:cd15052    13 ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSiLTELFGGVWPLPLVLCLLWVTLDVLFCTASIMHL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 133 TVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAlcafntaihtglmtrLSFC--GPNVITHFFCEVPPLLLLSCSSTY 210
Cdd:cd15052    93 CTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWL---------------ISIGisSPIPVLGIIDTTNVLNNGTCVLFN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 211 VNSVMIVLADAFYgiLNFLMTIVSYgfiissILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEKSKL 290
Cdd:cd15052   158 PNFVIYGSIVAFF--IPLLIMVVTY------ALTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRIS 229

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195725628 291 AGVLYTML-----SPTLNPLIYTLRNKEVKAA 317
Cdd:cd15052   230 PWLLSVFVwlgyvSSTINPIIYTIFNKTFRRA 261
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 48-311 5.97e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 43.96  E-value: 5.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIIctSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd14964     5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL--ASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 128 ELLL--LTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA-FNTAIHTGLMTRLSFCGPNVITHFFCEVPPLLLL 204
Cdd:cd14964    83 LASIwtTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLlLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLTWG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 205 SCSSTYVNSVMIVLADAFYgILNFLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYN 284
Cdd:cd14964   163 FLLVSFLLPLVAFLVIFSR-IVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAGQGL 241

                         250       260
                  ....*....|....*....|....*..
gi 1195725628 285 AEKSKLAGVLYtMLSPTLNPLIYTLRN 311
Cdd:cd14964   242 NLLSILANLLA-VLASTLNPFIYCLGN 267
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
 51-168 6.52e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 43.80  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELL 130
Cdd:cd17790    10 LSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVM 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd17790    90 NLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLI 127
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 51-170 7.42e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.95  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIiCTS--SIMPK-ALRGLVSKRNPISygGCMAQLYFLTWSASS 127
Cdd:cd15197    10 LFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADL-CVGliNVLTDiIWRITVEWRAGDF--ACKVIRYLQVVVTYA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAfcSMLAAGVWALCA 170
Cdd:cd15197    87 STYVLVALSIDRYDAICHPMNFSQSGRQA--RVLICVAWILSA 127
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
 42-176 9.95e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 43.31  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnPISYG--GCMAQLY 119
Cdd:cd15357     1 LPMSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNY-PFLFGpvGCYFKTA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195725628 120 FLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF----NTAIH 176
Cdd:cd15357    80 LFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLfsipNTSIH 140
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 55-155 1.01e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 43.23  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  55 ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrgLVSKRNPISYGGCMAQLYFLTWSASSELLLLTV 134
Cdd:cd15070    14 AVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLA 91

                          90       100
                  ....*....|....*....|.
gi 1195725628 135 MAYDRYAAICHPLHYSTMMSK 155
Cdd:cd15070    92 IAVDRYLRVKLTVRYRIVTTQ 112
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 58-321 1.23e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 42.90  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN-PISYGGCMAQLYFLTWSASSELLLLTVMA 136
Cdd:cd15306    17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 137 YDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAfntAIHTGLMTRLSFCGPNVITHFFCEVPPllllscsSTYVNSVMI 216
Cdd:cd15306    97 LDRYIAIKKPIQASQYNSRATAFIKITVVWLISI---GIAIPVPIKGIETDVDNPNNITCVLTK-------ERFGDFILF 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 217 VLADAFYGILNFLMTIVsygFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFYAYISPVSSYNAEKSKLAGVLYT 296
Cdd:cd15306   167 GSLAAFFTPLAIMIVTY---FLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQMLMEI 243

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195725628 297 M-----LSPTLNPLIYTLRNKEVKAALRKF 321
Cdd:cd15306   244 FvwigyVSSGVNPLVYTLFNKTFRDAFGRY 273
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 49-201 1.29e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 43.00  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrgLVSKRNPISYGGCMAQLYFLTWSASSE 128
Cdd:cd15068     8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF----------NTAIHTGLMTRLSFCGPNVITHFFCEV 198
Cdd:cd15068    86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAigltpmlgwnNCGQPKEGKNHSQGCGEGQVACLFEDV 165


                  ...
gi 1195725628 199 PPL 201
Cdd:cd15068   166 VPM 168
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 47-168 1.30e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 43.07  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVA-LTGNVLILLAITCNPGLHTPMY-FFLFNLATMDIICTSSIMPKALRGLVSKRNPISyGGCMAQLYFLTWS 124
Cdd:cd15320     6 CFLSVLILStLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMC 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15320    85 STASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTL 128
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
 44-276 1.50e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 42.77  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSL-YCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGC--MAQLYF 120
Cdd:cd15161     2 LFALFYILvFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCrlAGFLFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 121 LTWSASseLLLLTVMAYDRYAAICHPLHySTMMSKAFCSMLAAGV-WALCAFNTAIHTGLMTRLSFCGPNVITHFFCEVP 199
Cdd:cd15161    82 LNMYAS--LYFLACISVDRFLAIVHPVK-SMKIRKPLYAHVVCGFlWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1195725628 200 PLlllscsstyvnSVMIVLADAFygILNFLMTIVSYGFIISSILKMRTSEG--KQKAFSTcsshLIVVCMYYTAVFYAY 276
Cdd:cd15161   159 SR-----------GALVSLAVAF--TIPFVTTVTCYLLIIRSLRTGKREEKplKDKAIKM----IILVLTIFLICFVPY 220
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 46-168 1.55e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 42.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15978     5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15978    85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCL 127
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
 53-168 1.64e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 43.01  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  53 CVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKAlrgLVSKRNPISYG----GCMAQLYFLTWSASSE 128
Cdd:cd15217    12 CVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFV---LVSIRNGSAWTysvlSCKIVAFMAVLFCFHA 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15217    89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTL 128
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
 59-171 1.71e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.60  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  59 NVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLTVMAYD 138
Cdd:cd15335    18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195725628 139 RYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15335    98 RYWAITDAIEYARKRTAKRAGLMILTVWTISIF 130
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 48-183 1.91e-04

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 42.43  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYC-VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSImPKALRGLVSKRNPISYGGC--MAQLYFLTWS 124
Cdd:cd14999     5 VLSLMCvVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCrlLFSLDFLTMH 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195725628 125 ASseLLLLTVMAYDRYAAICHPLHySTMMSKAFCSMLAAGVWaLCAFNTAIHTGLMTRL 183
Cdd:cd14999    84 AS--IFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIW-LLSLLLTLPMAIMIRL 138
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
 44-168 2.01e-04

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 42.46  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15205     3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQST 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15205    83 AVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIV 127
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 44-317 2.17e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 42.48  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCV-ALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLT 122
Cdd:cd15056     2 VLSTFLSLVILlTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 123 WSASSELLLLTVMAYDRYAAIC-HPLHYStmMSKAFCSMLAAGVWALCAFNTAI-------HTGLMTRLSFCGPNVITH- 193
Cdd:cd15056    82 LLTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWVIPTFISFLpimqgwnHIGIEDLIAFNCASGSTSc 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 194 -FFCEVPPLLLLSCSSTYVNSVMIVLAdaFYGI-------LNFLMTIVSYGFIISSILKMRTSEGKQ--KAFSTCSSHLI 263
Cdd:cd15056   160 vFMVNKPFAIICSTVAFYIPALLMVLA--YYRIyvaareqAHQIRSLQRAGSSNHEADQHRNSRMRTetKAAKTLGIIMG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195725628 264 VVCMYYTAVFYAYI-SPVSSYNAEKSKLAGVLYT-MLSPTLNPLIYTLRNKEVKAA 317
Cdd:cd15056   238 CFCVCWAPFFVTNIvDPFIGYRVPYLLWTAFLWLgYINSGLNPFLYAFFNKSFRRA 293
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
 51-168 2.56e-04

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 42.25  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELL 130
Cdd:cd15091    10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIF 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15091    89 TLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLL 126
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 42-154 2.56e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 42.23  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALrgLVSKRNPISYGGCMAQLYF- 120
Cdd:cd15314     1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSM--VRSVETCWYFGDLFCKIHSs 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1195725628 121 --LTWSASSeLLLLTVMAYDRYAAICHPLHYSTMMS 154
Cdd:cd15314    79 fdITLCTAS-ILNLCFISIDRYYAVCQPLLYRSKIT 113
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
 44-171 2.82e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 42.12  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15391     3 LINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCsmLAAGVWAlCAF 171
Cdd:cd15391    83 SVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKC--IIASIWA-ISF 127
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
 51-171 3.11e-04

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 41.94  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELL 130
Cdd:cd15389    10 IIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 131 LLTVMAYDRYAAICHPLhySTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15389    90 TLTAIALDRHRVILHPL--KPRITPCQGVVVIAIIWIMASC 128
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
 47-311 3.19e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 41.58  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDI-ICTSSIMPKALRGLvsKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15072     6 ILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMgISLNALVAASSSLL--RRWPYGSEGCQAHGFQGFFTA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 SSELLLLTVMAYDRYAAICHP--LHYSTMMSKAFCSMLAAGVWALcafntaihtglMTRLSFcgpnviTHFFCEVpplLL 203
Cdd:cd15072    84 LASICSSAAIAWDRYHHYCTRskLQWSTAISLVLFVWLFSAFWAA-----------MPLLGW------GEYDYEP---LG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCSSTY----VNSVMIVLADAFYgilNFLMTIVSYGFIISSILKMRTSEGKQKAFST--------CSSHLIVVCMYYTA 271
Cdd:cd15072   144 TCCTLDYskgdRNYVSYLFTMAFF---NFILPLFILLTSYSSIEQKLKKEGHLRFNTGlplltlliCWGPYAILALYAAI 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195725628 272 VFYAYISPvssynaeKSKLAGVLYTMLSPTLNPLIYTLRN 311
Cdd:cd15072   221 TDVTSISP-------KLRMVPALLAKTSPTINAILYALGN 253
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 40-168 3.30e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 41.68  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  40 YQLPLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLY 119
Cdd:cd14971     1 WIVPLFFALIFL--LGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195725628 120 FLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd14971    79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVV 127
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 40-171 3.59e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 41.79  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  40 YQLPLFFCFLSlyCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPKALrgLVSKRNPISYGGCMAQLY 119
Cdd:cd15079     1 YLLGFIYIFLG--IVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFI--YNSFYEGWALGPLGCQIY 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195725628 120 FLTWSAS--SELLLLTVMAYDRYAAICHPLHySTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15079    76 AFLGSLSgiGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALP 128
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
 54-283 3.72e-04

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 41.52  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRnPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15090    13 VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTW-PFGNILCKIVISIDYYNMFTSIFTLC 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALcafNTAIHTGLMTRLSfcgpnvITHFFCEVPPLLLLSCSSTYVNS 213
Cdd:cd15090    92 TMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWIL---SSAIGLPVMFMAT------TKYRQGSIDCTLTFSHPSWYWEN 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195725628 214 VMIVLADAFYGILNFLMTIVSYGFII---SSILKMRTSEGKQKAFSTCSSHLIVVcmyyTAVFYAYISPVSSY 283
Cdd:cd15090   163 LLKICVFIFAFIMPVLIITVCYGLMIlrlKSVRMLSGSKEKDRNLRRITRMVLVV----VAVFIVCWTPIHIY 231
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 54-171 4.24e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 41.46  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLH--TPMYFFLFNLATMDIICTSSIMPKALRGLVSKRN-PISYGGCMAQLYFLTWSASSELL 130
Cdd:cd14981    13 FGVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEwDGGQPLCDYFGFMMSFFGLSSLL 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd14981    93 IVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALL 133
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
 42-170 5.26e-04

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 41.00  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCflSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd15194     3 LPILYC--LVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYII 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15194    81 SVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSC 129
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 59-171 6.02e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.99  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  59 NVLILLAITCNPGLHTPMYFFLFNLATMDII---CTSSIMpkalrgLVSKRNPISYGG---CMAQLYFLTWSASSELLLL 132
Cdd:cd15085    18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMmalCGTTIV------TVTNYEGYFYLGdafCIFQGFAVNYFGIVSLWSL 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195725628 133 TVMAYDRYAAICHPLHYSTMMSKAFCSMLAAgVWALCAF 171
Cdd:cd15085    92 TLLAYERYNVVCKPMGGLKLSTKRGYQGLLF-IWLFCLF 129
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
 46-181 6.07e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 40.82  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGC----MAQLYFL 121
Cdd:cd15066     4 FAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCdvwnSLDVYFS 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195725628 122 TWSasseLLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW---ALCAFnTAIHTGLMT 181
Cdd:cd15066    84 TAS----ILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWispALISF-LPIFLGWYT 141
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
 48-318 6.34e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.92  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIictssimpkaLRGLVSKRNPISYGGCMAQLYFLTWSA-- 125
Cdd:cd15102     7 FVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDL----------LAGAAYLANILLSGARTLRLSPAQWFLre 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 126 -------SSELLLLTVMAYDRYAAICHP-LHYSTMMSKAFcsMLAAGVWALCAfntaihtgLMTRLSFCGPNVITHffce 197
Cdd:cd15102    77 gsmfvalSASVFSLLAIAIERHLTMAKMkPYGASKTSRVL--LLIGACWLISL--------LLGGLPILGWNCLGA---- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 198 vppllLLSCSST---YVNSVMIVLADAFYGIlnfLMTIVSYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMYYTAVFY 274
Cdd:cd15102   143 -----LDACSTVlplYSKHYVLFCVTIFAGI---LAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFI 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195725628 275 AYISPVSSY----NAEKSKLAGVLY--------TMLSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15102   215 ACWGPLFILllldVACPVKTCPILYkadwflalAVLNSALNPIIYTLRSRELRRAV 270
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
 48-171 7.31e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 40.62  E-value: 7.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15092     7 YLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15092    86 STFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASV 129
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
 45-175 8.06e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 40.36  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  45 FFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15390     4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYStmMSKAFCSMLAAGVWaLCAFNTAI 175
Cdd:cd15390    84 VAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIW-LASFLLAL 131
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
 44-168 8.60e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 40.51  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDiICTSSIMPkALRGLVSKRNpISYGGCMAQLYFLTW 123
Cdd:cd15905     1 IFWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLAD-LLTGVALP-FIPGMSNESR-RGYHSCLFVYVAPNF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15905    78 LFLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWAL 122
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 54-168 9.41e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 40.27  E-value: 9.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15402    13 VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNIT 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15402    93 GIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVL 127
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 54-171 1.06e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 40.11  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15073    13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLT 92

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMlAAGVWALCAF 171
Cdd:cd15073    93 VVAVDRYLTICRPDLGRKMTTNTYTVM-ILLAWTNAFF 129
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
 42-168 1.06e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 40.05  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFcfLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFL 121
Cdd:cd14985     3 IPALY--IAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 122 TWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd14985    81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVV 127
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 48-167 1.13e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 40.22  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGN---VLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15355     7 YLALFVVGTVGNsitLYTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFLRD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195725628 125 ASSELLLLTV--MAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWA 167
Cdd:cd15355    87 ACTYATALNVasLSVERYLAICHPFKAKSLMSRSRTKKFISAIWL 131
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 51-170 1.31e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 39.80  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELL 130
Cdd:cd15979    10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTF 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15979    90 SLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSG 129
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
 47-168 1.33e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 39.77  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVA-LTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSImPKALRGLVSKRNPisYGGCMAQLYFLTWSA 125
Cdd:cd15094     5 VLYGLICIVgLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGL-PFLIVTMILKYWP--FGAAMCKIYMVLTSI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1195725628 126 SS--ELLLLTVMAYDRYAAICHPLH---YSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15094    82 NQftSSFTLTVMSADRYLAVCHPIRsmrYRTPFIAKVVCATTWSISFL 129
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
 44-170 1.35e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 39.56  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVAltGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTW 123
Cdd:cd15329     5 IVLLIIILGTVV--GNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 124 SASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15329    83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSA 129
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
 42-171 1.43e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 39.98  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  42 LPLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLY-- 119
Cdd:cd15048     3 LAVLISVLIL--VTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVvd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195725628 120 FLTWSASSelllLTVMA--YDRYAAICHPLHYSTMMSKAFCSMLAAGVWaLCAF 171
Cdd:cd15048    81 YTLCTASA----LTIVLisLDRYLSVTKAVKYRAKQTKRRTVLLMALVW-ILAF 129
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
 51-168 1.44e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRglVSKRNPISYGGCMAQLY-FLTWSAS-SE 128
Cdd:cd15131    10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYR--LWQYRPWNFGDLLCKLFqFVSESCTyST 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15131    88 ILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAV 127
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
 54-168 1.48e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 39.78  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15199    13 LGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLT 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15199    93 AVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLL 127
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 54-170 1.56e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.78  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDI-ICTSSIMPKALRGlVSKRNPISYGGCMAQLYFLTWSASSELLLL 132
Cdd:cd15386    13 VATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLvVALFQVLPQLIWE-ITYRFQGPDLLCRAVKYLQVLSMFASTYML 91

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1195725628 133 TVMAYDRYAAICHPLHYSTMMSKAFCSMLAAgVWALCA 170
Cdd:cd15386    92 IMMTVDRYIAVCHPLRTLQQPSRQAYLMIGA-TWLLSC 128
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
 49-168 1.59e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 39.39  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVALT-GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15333    11 LALITLATTlSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTA 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15333    91 SILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVI 131
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
 53-170 1.96e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 39.34  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  53 CVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkaLRGLVSKRNPISYGGCMAQLYF----LTWSASse 128
Cdd:cd15060    12 AFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLP--LNVAYFLLGKWLFGIHLCQMWLtcdiLCCTAS-- 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195725628 129 LLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15060    88 ILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSA 129
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
 48-170 2.00e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 39.15  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCValTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15323     9 FLIVFTI--VGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15323    87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISA 129
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 58-182 2.00e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 39.24  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPkaLRGLVSKRNPISYGGCMAQLYF---LTWSASSELLLLtV 134
Cdd:cd15051    17 GNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLP--FSAIYELRGEWPLGPVFCNIYIsldVMLCTASILNLF-A 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195725628 135 MAYDRYAAICHPLHYSTMMS--KAFCSMLAAGVWALCAFNTAIHTGLMTR 182
Cdd:cd15051    94 ISLDRYLAITAPLRYPSRVTprRVAIALAAIWVVSLAVSFLPIHLGWNTP 143
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 43-206 2.27e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 39.32  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLslYCVALTGNVLILLAITCN-PGL-HTPMYFFLFNLATMD----IIC-----TSSIMPKALRGLVSkrnpisy 111
Cdd:cd15098     4 PVVFGLI--FCLGVLGNSLVITVLARVkPGKrRSTTNVFILNLSIADlfflLFCvpfqaTIYSLPEWVFGAFM------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 112 ggCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL---CAFNTAIHTGLMTR-----L 183
Cdd:cd15098    75 --CKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLslaMASPVAVHQDLVHHwtasnQ 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1195725628 184 SFCGPN-----------VITHFFCEVPPLLLLSC 206
Cdd:cd15098   153 TFCWENwpekqqkpvyvVCTFVFGYLLPLLLITF 186
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
 75-170 2.36e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 38.96  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  75 PMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMS 154
Cdd:cd15372    33 PSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRS 112

                          90
                  ....*....|....*.
gi 1195725628 155 KAFCSMLAAGVWALCA 170
Cdd:cd15372   113 RRFALCMCTAIWLIAA 128
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
 49-171 2.67e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 38.78  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  49 LSLYCVAL---TGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15334     5 LTLSILALmttAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCC 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15334    85 TCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIF 130
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 54-147 2.88e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.03  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMD-IICTSSIMPKALRGLVSKrnpiSYGG---CMAQLYFLTWSASSEL 129
Cdd:cd15387    13 LALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADlVVAVFQVLPQLIWDITFR----FYGPdflCRLVKYLQVVGMFAST 88

                          90
                  ....*....|....*...
gi 1195725628 130 LLLTVMAYDRYAAICHPL 147
Cdd:cd15387    89 YMLLLMSIDRCLAICQPL 106
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
 46-168 2.88e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 38.80  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  46 FCFLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALR-GLVSKRNPISYGGCMAQLYFLTWS 124
Cdd:cd15310     5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYlEVTGGVWNFSRICCDVFVTLDVMM 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFC---SMLAAGVWAL 168
Cdd:cd15310    85 CTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCrrvSLMITAVWVL 131
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
 48-168 2.95e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 38.65  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15301     9 VLSL--VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15301    87 SVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWII 127
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 48-168 3.58e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 38.59  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSiMPKALRGLVSKRNpISYGGCMAQLYFL--TWSA 125
Cdd:cd15088     7 FGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLG-MPFLIHQFAIDGQ-WYFGEVMCKIITAldANNQ 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15088    85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAA 127
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 51-171 3.92e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 38.36  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELL 130
Cdd:cd15321    16 LILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 131 LLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWALCAF 171
Cdd:cd15321    96 HLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAV 136
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
 54-154 4.02e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 38.22  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15209    13 VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNIT 92

                          90       100
                  ....*....|....*....|.
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMS 154
Cdd:cd15209    93 AIAINRYCYICHSLQYDRLYS 113
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
 47-168 4.78e-03

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 38.30  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYC-VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSImPKALRGLVSKRNPISYGGCMAQLYFLTWSA 125
Cdd:cd15973     5 FIYALVClVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQHWPFGSAMCRTVLSVDGINM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195725628 126 SSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15973    84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWIL 126
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 54-264 4.96e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 38.08  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15083    13 IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWalcafntaIHTGLMTRLSFCGPNVIthffceVPPLLLLSCSSTYVNS 213
Cdd:cd15083    93 AIAVDRYLVITRPMKASVRISHRRALIVIAVVW--------LYSLLWVLPPLFGWSRY------VLEGLLTSCSFDYLSR 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195725628 214 -------VMIVLADAFYGILnfLMTIVSYGFIISSIlkmRTSEGKQKAFSTCSSHLIV 264
Cdd:cd15083   159 ddanrsyVICLLIFGFVLPL--LIIIYCYSFIFRAV---RRHEKAMKEMAKRFSKSEL 211
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 44-166 5.06e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 38.22  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  44 LFFCFLSLYCVALTGNVLILLaITCNPGLHTPMYFFLFNLATMDIICTSSImpkALRGLVSKRNPISYGGC----MAQLY 119
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTL---PFQIYYYILFQWSFGEFackiVSGLY 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195725628 120 FLTWSASseLLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVW 166
Cdd:PHA03087  119 YIGFYNS--MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW 163
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
 79-168 5.14e-03

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 38.11  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  79 FLFNLATMD---IICTSSIMPKALRGLVSKRNPISyggCMAQLYFLTWSASSELLLLTVMAYDRYAAICHPLHYSTMMSK 155
Cdd:cd15201    38 YLFNLAVADfllIICLPFRTDYYLRGKHWKFGDIP---CRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISV 114

                          90
                  ....*....|...
gi 1195725628 156 AFCSMLAAGVWAL 168
Cdd:cd15201   115 RKAAIIACGLWLL 127
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 54-318 5.16e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 38.02  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15074    13 LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 134 VMAYDRYAAICHPlHYSTMMSKAFCSMLAAGVWALCAFNTaihtglmtrlsfcgpnvithffceVPPLL----------L 203
Cdd:cd15074    93 AISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWA------------------------VAPLVgwgsygpepfG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 204 LSCS------STYVNSVMIVLADAFYGILNFLMTIV-SYGFIISSILKMRTSE----GKQKAFSTCSSHLIVVCMYYTAV 272
Cdd:cd15074   148 TSCSidwtgaSASVGGMSYIISIFIFCYLLPVLIIVfSYVKIIRKVKSSRKRVagfdSRSKRQHKIERKVTKVAVLICAG 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195725628 273 F------YAYISPVSSYNAEKS--KLAGVLYTML---SPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15074   228 FliawtpYAVVSMWSAFGSPDSvpILASILPALFaksSCMYNPIIYLLFSSKFRQDL 284
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 47-168 5.54e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 38.01  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCV-ALTGNVLILLAITCNPGLHTPMY-FFLFNLATMDIICTSSIMPKALRGLVSKRNPISyGGCMAQLYFLTWS 124
Cdd:cd15319     5 CLLSLLILwTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMC 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195725628 125 ASSELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15319    84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTL 127
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
 48-168 6.02e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 37.87  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASS 127
Cdd:cd15921     7 YILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYS 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1195725628 128 ELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAGVWAL 168
Cdd:cd15921    87 SIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWIL 127
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
 48-318 6.88e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 37.46  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  48 FLSLYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIIC-TSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSAS 126
Cdd:cd15349     7 FICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLLTgTSYLVNICLSGERTFRLTPALWFLREGLLFTALAAS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 127 SELLLLTvmAYDRYAAICHPLHYSTmmskAFCSMLAAGVWALCAfntaIHTGLMTRLSFCGPNVITHFfcEVPPLLLLSC 206
Cdd:cd15349    87 TFSLLVT--AVERYATMVRPVAENT----ATKTYRVYGMIVLCW----ILAFLIGFLPLLGWNCLCDF--RSCSSLLPLY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628 207 SSTYVNSVMIVLADAFYGILNFLMTIvsYGFIISSILKMRTSEGKQKAFSTCSSHLIVVCMY---YTAVFYAYISPVSSY 283
Cdd:cd15349   155 SKSYILFCLVIFFIILLTIIGLYFAI--YCLVRASGQRVISARSRRRSLRLLKTVLMILGAFmvcWGPLFILLLVDFFCS 232

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195725628 284 NAEKSKLAGVLYTM----LSPTLNPLIYTLRNKEVKAAL 318
Cdd:cd15349   233 SRSCKPLFGMEWVLalavLNSAINPLIYSFRSLEVRRAV 271
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 51-170 7.22e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 37.74  E-value: 7.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  51 LYCVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDI-ICTSSIMPKALRGLVSKrnpiSYGG---CMAQLYFLTWSAS 126
Cdd:cd14986    10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLvVAFFTVLTQIIWEATGE----WVAGdvlCRIVKYLQVVGLF 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195725628 127 SELLLLTVMAYDRYAAICHPLHYSTMMSKAFCSMLAAgvWALCA 170
Cdd:cd14986    86 ASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVA--WVLSF 127
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 58-170 7.35e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 37.62  E-value: 7.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  58 GNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLTVMAY 137
Cdd:cd15322    17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195725628 138 DRYAAICHPLHYSTMMSKAFCSMLAAGVWALCA 170
Cdd:cd15322    97 DRYWSITQAIEYNLKRTPRRIKCIIFIVWVISA 129
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
 54-151 8.19e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 37.23  E-value: 8.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  54 VALTGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYFLTWSASSELLLLT 133
Cdd:cd15299    16 VTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLL 95

                          90
                  ....*....|....*...
gi 1195725628 134 VMAYDRYAAICHPLHYST 151
Cdd:cd15299    96 VISFDRYFSITRPLTYRA 113
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
 47-175 8.30e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 37.30  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  47 CFLSLYCVAltGNVLILLAITCNPGLHTPMYFFLFNLATMDIICTSSIMPKALRGLVSKRNPISYGGCMAQLYF-LTWSA 125
Cdd:cd15049     8 GSLSLVTVG--GNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALdYVASN 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195725628 126 SSELLLLtVMAYDRYAAICHPLHYSTMMSK--AFCSMLAAGVWALCAFNTAI 175
Cdd:cd15049    86 ASVMNLL-LISFDRYFSVTRPLTYRAKRTPkrAILMIALAWVISFVLWAPAI 136
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
 43-147 9.21e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 37.26  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195725628  43 PLFFCFLSLycVALTGNVLILLAITCNPGLHTPMYFFLFNLATMDI---IC----TSSI--MPKALRGLVSkrnpisygg 113
Cdd:cd15095     4 PLIFAIIFL--VGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLaflVCcvpfTAALyaTPSWVFGDFM--------- 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1195725628 114 CMAQLYFLTWSASSELLLLTVMAYDRYAAICHPL 147
Cdd:cd15095    73 CKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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