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Conserved domains on  [gi|1195666580|ref|XP_021010901|]
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olfactory receptor 142 [Mus caroli]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.78e-155

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 435.10  E-value: 1.78e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.78e-155

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 435.10  E-value: 1.78e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-296 1.83e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 149.96  E-value: 1.83e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEK----FIVMANsglFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:pfam13853 161 DIKVNNiyglFVVTST---FGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 265 EDKLVSVF----YTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:pfam13853 238 VPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCV 273
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.78e-155

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 435.10  E-value: 1.78e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 24-289 4.34e-134

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 380.78  E-value: 4.34e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15226     2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15226    82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAF 263
Cdd:cd15226   162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                         250       260
                  ....*....|....*....|....*.
gi 1195666580 264 TEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15226   242 PVDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 24-289 1.79e-131

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 374.13  E-value: 1.79e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd13954     2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd13954    82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd13954   162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd13954   242 YSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 24-296 2.14e-129

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 369.48  E-value: 2.14e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15225     2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15225    82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15225   162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15225   242 YSpeTDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 26-289 1.38e-121

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 349.11  E-value: 1.38e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15230     4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15230    84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15230   164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15230   244 ldQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 26-289 2.82e-117

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 338.15  E-value: 2.82e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15936     4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15936    84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFTE 265
Cdd:cd15936   164 ACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM 243

                         250       260
                  ....*....|....*....|....
gi 1195666580 266 DKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15936   244 DKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 26-289 4.53e-116

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 335.18  E-value: 4.53e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15940     4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15940    84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFTE 265
Cdd:cd15940   164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE 243

                         250       260
                  ....*....|....*....|....
gi 1195666580 266 DKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15940   244 DKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 9-297 6.22e-115

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 333.18  E-value: 6.22e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580   9 ELIFTGLFQDPEVQKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVK 88
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  89 TISLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCG 168
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 169 PNVIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVIL 247
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195666580 248 YFGPGAFIYMRPSSAFTE--DKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALR 292
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 26-296 8.09e-112

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 324.93  E-value: 8.09e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15229     4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15229    84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA-- 262
Cdd:cd15229   164 SCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAss 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15229   244 SVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 11-293 6.89e-111

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 322.73  E-value: 6.89e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  11 IFTGLFQDPEVQKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTI 90
Cdd:cd15408     2 ILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  91 SLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPN 170
Cdd:cd15408    82 SFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 171 VIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYF 249
Cdd:cd15408   162 VINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLFY 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 250 GPGAFIYMRPSSAFTE--DKLVSVFYTVITPMLNPIVYTLRNTEMK 293
Cdd:cd15408   242 GSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 26-289 5.03e-110

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 319.82  E-value: 5.03e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15911     4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15911    84 AATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15911   164 SCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 265 ED--KLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15911   244 RDlnKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 24-289 1.23e-108

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 316.35  E-value: 1.23e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15912     2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15912    82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPS-- 260
Cdd:cd15912   162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSqs 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 261 SAFTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15912   242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 26-297 2.43e-108

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 316.12  E-value: 2.43e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15417     4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15417    84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15417   164 SCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHS 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15417   244 qdQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 11-297 9.04e-108

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 314.98  E-value: 9.04e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  11 IFTGLFQDPEVQKLCFVLFLPVYLATLLGN-GLIFVtVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKT 89
Cdd:cd15410     2 ILLGFTDYPELQVPLFLVFLAIYGITLLGNlGMIVL-IKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  90 ISLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGP 169
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 170 NVIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILY 248
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTiLRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195666580 249 FGPGAFIYMRPSSAFT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15410   241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALR 291
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 24-296 1.46e-107

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 313.82  E-value: 1.46e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15231     2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15231    82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15231   162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15231   242 YSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 24-289 3.38e-106

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 310.15  E-value: 3.38e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15227     2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15227    82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15227   162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 F--TEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15227   242 SpsLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 26-297 1.16e-105

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 309.25  E-value: 1.16e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15411     4 FVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15411    84 ATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15411   164 SCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYS 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 265 E--DKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15411   244 LgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 22-296 2.21e-105

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 308.38  E-value: 2.21e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  22 QKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFF 101
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHP 181
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 LLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPS 260
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195666580 261 SAF--TEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15235   241 SSYsaDKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 26-289 5.12e-105

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 307.23  E-value: 5.12e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15431     4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLiHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15431    84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAF-LLTVIPVLTMPLHFCGPNVINHFFCEVQALLKL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTfMEKFIVMANSGLFSIIS--LFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAF 263
Cdd:cd15431   163 ACSDT-SLNEILMFATSIFTLLLpfSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKS 241

                         250       260
                  ....*....|....*....|....*...
gi 1195666580 264 T--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15431   242 SsdQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 26-295 1.03e-104

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 306.78  E-value: 1.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15421     4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15421    84 GGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15421   164 SCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHS 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15421   244 peQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 23-289 2.46e-104

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 305.35  E-value: 2.46e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15237     1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195666580 262 AFTE--DKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15237   241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 24-297 1.19e-102

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 301.53  E-value: 1.19e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15419     2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15419    82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15419   162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15419   242 SSpeQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 26-297 1.75e-102

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 301.21  E-value: 1.75e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15416     4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15416    84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15416   164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 265 ED--KLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15416   244 MDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 23-289 2.54e-102

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 300.30  E-value: 2.54e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15918     1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15918    81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15918   161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195666580 262 AFT--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15918   241 SHSasKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 26-289 6.44e-101

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 296.78  E-value: 6.44e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15938     4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15938    84 GAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRkhSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFTE 265
Cdd:cd15938   164 ACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV 241

                         250       260
                  ....*....|....*....|....
gi 1195666580 266 DKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15938   242 DKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 26-289 3.30e-99

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 292.67  E-value: 3.30e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15915     4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15915    84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRK--HSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAF 263
Cdd:cd15915   164 ACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLkvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGD 243

                         250       260
                  ....*....|....*....|....*...
gi 1195666580 264 T--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15915   244 SleQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 26-297 3.55e-99

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 292.78  E-value: 3.55e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15415     4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15415    84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15415   164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15415   244 leQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 26-296 4.69e-99

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 292.41  E-value: 4.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15228     4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15228    84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15228   164 ACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPV 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195666580 265 EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15228   244 LVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 26-297 9.42e-99

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 292.02  E-value: 9.42e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15414     4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15414    84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15414   164 SCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15414   244 ldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALR 278
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 26-295 1.11e-98

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 291.61  E-value: 1.11e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15429     4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15429    84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15429   164 ACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15429   244 alQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 25-297 3.04e-98

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 290.38  E-value: 3.04e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  25 CFVLFLPVYLATLLGN-GLIFVTvSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15413     3 LFGLFLVIYLTTVMGNlGMIILT-RLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15413    82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS- 261
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSs 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 262 -AFTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15413   242 hSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALK 278
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 24-295 4.52e-98

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 290.00  E-value: 4.52e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15420     2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15420    82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15420   162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 263 FTE--DKLVSVFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15420   242 NSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 24-289 1.58e-97

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 288.17  E-value: 1.58e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15937     2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15937    82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAF 263
Cdd:cd15937   162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                         250       260
                  ....*....|....*....|....*.
gi 1195666580 264 TEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15937   242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 24-289 4.00e-97

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 287.23  E-value: 4.00e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15232     2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15232    82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15232   162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15232   242 YSpeKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 24-289 7.98e-97

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 286.28  E-value: 7.98e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSI-SKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15935     2 LLFVLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15935    82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15935   162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15935   242 SSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 14-297 1.80e-96

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 286.19  E-value: 1.80e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  14 GLFQDPEVQKLCFVLFLPVYLATLLGN-GLIFVtVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISL 92
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNlGMILL-ITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  93 KGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVI 172
Cdd:cd15406    80 PECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 173 DHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGP 251
Cdd:cd15406   160 NHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGS 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1195666580 252 GAFIYMRPSSA--FTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15406   240 IIFMYLKPSSSssMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALK 287
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 11-297 3.60e-96

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 285.48  E-value: 3.60e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  11 IFTGLFQDPEVQKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTI 90
Cdd:cd15945     2 ILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  91 SLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPN 170
Cdd:cd15945    82 PFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 171 VIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYF 249
Cdd:cd15945   162 TINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLFY 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195666580 250 GPGAFIYMRPSSAFT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15945   242 GTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALK 291
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 26-289 2.70e-95

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 282.59  E-value: 2.70e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15947     4 FVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15947    84 GSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15947   164 ACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195666580 265 ED--KLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15947   244 QDqgKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 24-289 3.63e-95

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 282.25  E-value: 3.63e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15224     2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15224    82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPS-- 260
Cdd:cd15224   162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKai 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 261 SAFTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15224   242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 26-297 3.69e-95

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 282.37  E-value: 3.69e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15409     4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15409    84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS--A 262
Cdd:cd15409   164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSlyA 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 263 FTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15409   244 LDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 23-297 4.03e-94

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 280.05  E-value: 4.03e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195666580 262 --AFTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15412   241 eeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALK 278
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 24-296 2.95e-93

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 277.79  E-value: 2.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLL-AEVKTISLKGCLTQIFFF 102
Cdd:cd15916     2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15916    82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15916   162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 262 AFTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15916   242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 11-297 7.12e-90

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 269.73  E-value: 7.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  11 IFTGLFQDPEVQKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTI 90
Cdd:cd15944     2 ILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  91 SLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPN 170
Cdd:cd15944    82 SFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 171 VIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYF 249
Cdd:cd15944   162 IINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLFY 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195666580 250 GPGAFIYMRPSSAFT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15944   242 GTVIFMYLRPTSVYSldQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFK 291
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 24-289 2.84e-89

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 267.31  E-value: 2.84e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15914     2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15914    82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMA-NSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15914   162 SLACTDTSLNVLVDFViHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 F--TEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15914   242 YslDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 26-296 2.21e-88

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 265.21  E-value: 2.21e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15234     4 FGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15234    84 GGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMrpSSAFT 264
Cdd:cd15234   164 ACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYI--SSAVT 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 265 ED----KLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15234   242 HSsrktAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 23-289 2.65e-88

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 264.62  E-value: 2.65e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15430    81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15430   161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195666580 262 --AFTEDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15430   241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 26-296 5.67e-88

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 264.30  E-value: 5.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15942     4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15942    84 GCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15942   164 ACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195666580 265 EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15942   244 LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 26-295 7.03e-88

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 263.90  E-value: 7.03e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15407     4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15407    84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15407   164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15407   244 mdTDKMASVFYTMVIPMLNPLVYSLRNKEVKSA 276
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 24-296 3.39e-87

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 262.36  E-value: 3.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15424     2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15424    82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15424   162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 263 FTE--DKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15424   242 STPdrDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 24-296 2.05e-85

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 257.85  E-value: 2.05e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHS-PMYFFLSSLSLVEICYSSTVAPKFITDLLA-EVKTISLKGCLTQIFF 101
Cdd:cd15941     2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHP 181
Cdd:cd15941    82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 LLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPS 260
Cdd:cd15941   162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 261 SAFTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15941   242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 24-296 4.84e-84

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 254.33  E-value: 4.84e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15428     2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15428    82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKfIVMANSGLFSIIS--LFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15428   162 KLASTDTHQAE-MAMFIMCVFTLVLpvLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 262 AFTE--DKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15428   241 STSKeyDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 23-296 1.20e-83

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 253.07  E-value: 1.20e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15434    81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRP-- 259
Cdd:cd15434   161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPkn 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 260 SSAFTEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15434   241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 24-296 3.12e-83

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 252.00  E-value: 3.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15236     2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15236    82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVI-LISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15236   162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIaATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 263 FTEDK--LVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15236   242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 26-296 6.52e-83

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 251.18  E-value: 6.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15405     4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15405    84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:cd15405   164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195666580 265 --EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15405   244 vnQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 22-297 1.35e-82

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 250.47  E-value: 1.35e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  22 QKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFF 101
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHP 181
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 LLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPS 260
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195666580 261 SAFT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAIR 297
Cdd:cd15418   241 SSHTpdRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALK 279
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 24-289 1.42e-82

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 250.09  E-value: 1.42e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15946     2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15946    82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15946   162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15946   242 YSpeRDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 24-296 1.88e-82

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 250.09  E-value: 1.88e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15233     2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15233    82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYA-VILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15233   162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 263 FT--EDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15233   242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 24-289 4.37e-81

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 246.46  E-value: 4.37e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15913     2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLL 183
Cdd:cd15913    82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 184 KLACTDTFMEKFIVMANSGLFSIISLFILVSSYA-VILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSA 262
Cdd:cd15913   162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTlVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 263 FTED--KLVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15913   242 NSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 23-296 8.15e-80

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 243.54  E-value: 8.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 262 AFTED--KLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15432   241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 23-296 1.04e-71

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 222.74  E-value: 1.04e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  23 KLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15433     1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPL 182
Cdd:cd15433    81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 LKLACTDTFMEKFIVMANSGLFSIISLFILVSSY-AVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSS 261
Cdd:cd15433   161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYgHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 262 AF--TEDKLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15433   241 RYsqAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 26-296 1.87e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 204.06  E-value: 1.87e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15223     4 SLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd15223    84 TAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHItVVILYF---GPGAFIYMRPSS 261
Cdd:cd15223   164 ACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHL-IVILFFytaVLVSSLTYRFGK 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 262 AFTED--KLVSVFYTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15223   243 TIPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 29-292 5.64e-60

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 192.50  E-value: 5.64e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15917     7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15917    87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFTEDK 267
Cdd:cd15917   167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPP 246

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 268 ----LVSVFYTVITPMLNPIVYTLRNTEM 292
Cdd:cd15917   247 hvhiLLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 27-288 3.43e-58

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 188.01  E-value: 3.43e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15950     5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLA 186
Cdd:cd15950    85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 187 CTDT-FMEKFIVMANSGLFSIISLFILVsSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAF-IYMRPSS-- 261
Cdd:cd15950   165 CADPrPSSLYSITGSTLVVGTDSAFIAV-SYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGqg 243

                         250       260
                  ....*....|....*....|....*...
gi 1195666580 262 -AFTEDKLVSVFYTVITPMLNPIVYTLR 288
Cdd:cd15950   244 vPPHTQVLLADLYLLVPPMLNPIIYGMR 271
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 29-292 5.58e-54

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 177.19  E-value: 5.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15952     7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15952    87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTfmeKFIVMANSGLFSIISLFILV--SSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMR------- 258
Cdd:cd15952   167 SI---RINIIYGLFAISVLVLDVILiaLSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLThrfghni 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195666580 259 PSSAFTedkLVSVFYTVITPMLNPIVYTLRNTEM 292
Cdd:cd15952   244 PRYIHI---LLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 29-291 1.47e-52

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 173.60  E-value: 1.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSR-QVCHMLVAGSwLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLAC 187
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNsRIAKLGLVGL-IRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 188 TDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMrpSSAFTED 266
Cdd:cd15953   166 GDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL--THRFGQG 243

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195666580 267 K------LVSVFYTVITPMLNPIVYTLRNTE 291
Cdd:cd15953   244 IaphihiILANLYLLVPPMLNPIIYGVKTKE 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 29-288 9.78e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 168.62  E-value: 9.78e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15221    87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFiymrpsSAFTE-- 265
Cdd:cd15221   167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFF------SFLTHrf 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195666580 266 --------DKLVSVFYTVITPMLNPIVYTLR 288
Cdd:cd15221   241 grhiprhvHILLANLYVLVPPMLNPIVYGVK 271
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 26-291 1.97e-50

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 168.06  E-value: 1.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15222     4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCdLHP-LLK 184
Cdd:cd15222    84 SFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYC-LHQdVMK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 185 LACTDTFMEKFIvmansGLFSII------SLFILVsSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPgaFI-- 255
Cdd:cd15222   163 LACSDTRVNSIY-----GLFVVLstmgldSLLILL-SYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVP--MIgl 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195666580 256 -----YMRPSSAFTEdKLVSVFYTVITPMLNPIVYTLRNTE 291
Cdd:cd15222   235 smvhrFGKHASPLVH-VLMANVYLLVPPVLNPIIYSVKTKQ 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-289 2.14e-46

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 157.51  E-value: 2.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15951     7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15951    87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTfmekfIVMANSGLFSIIS-----LFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMrpSSA 262
Cdd:cd15951   167 DT-----RVSRAYGLSVAFLvggldVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL--THR 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195666580 263 FTEDK------LVSVFYTVITPMLNPIVYTLRN 289
Cdd:cd15951   240 FGHNVpphvhiLIANVYLLVPPMLNPIIYGVRT 272
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 29-292 1.01e-44

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 153.10  E-value: 1.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15956     7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15956    87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYM----RPSSAF 263
Cdd:cd15956   167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPS 246

                         250       260
                  ....*....|....*....|....*....
gi 1195666580 264 TEDKLVSVFYTVITPMLNPIVYTLRNTEM 292
Cdd:cd15956   247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-296 1.83e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 149.96  E-value: 1.83e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEK----FIVMANsglFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFT 264
Cdd:pfam13853 161 DIKVNNiyglFVVTST---FGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195666580 265 EDKLVSVF----YTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:pfam13853 238 VPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCV 273
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 29-293 1.35e-39

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 140.04  E-value: 1.35e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15948     8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLvagswlgGLIHSIIQIIITIPLPF-------CGPNVIDHYFCDLHP 181
Cdd:cd15948    88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKI-------GLAALARAVTLMTPLPFllrrlpyCRSHVIAHCYCEHMA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 LLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGP----GAFIY 256
Cdd:cd15948   161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAvLSLASKEEQLKAFGTCGSHICAILVFYTPvvlsSTMHR 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 257 MRPSSAFTEDKLVSVFYTVITPMLNPIVYTLRNTEMK 293
Cdd:cd15948   241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 8-293 9.66e-38

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 135.29  E-value: 9.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580   8 TELIFTGLFQDPEVQKLCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEV 87
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  88 KTISLKGCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFC 167
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 168 GPNVIDHYFCDLHPLLKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVIL-ISLRKHSAEGRRKALSTCASHITVVI 246
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195666580 247 LYFGPGA-------FIYMRPSSAFTedkLVSVFYTVITPMLNPIVYTLRNTEMK 293
Cdd:cd15949   242 AFYVPIAvsslihrFGQNVPPPTHI---LLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 29-292 8.24e-37

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 132.64  E-value: 8.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15954     7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLACT 188
Cdd:cd15954    87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFMEKFIVMANSGLFSIISLFILVSSYAVILIS-LRKHSAEGRRKALSTCASHITVVILYFGPGAFIYM--RPSSAFTE 265
Cdd:cd15954   167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAvVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahRFGGHHIT 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195666580 266 DK---LVSVFYTVITPMLNPIVYTLRNTEM 292
Cdd:cd15954   247 PHihiIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 39-285 3.15e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 117.40  E-value: 3.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  39 GNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLA-EVKTISLKGCLTQIFFFHFFGVVEIILLVVMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 118 YDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIdhyFCDLHPLLKLACtdtfmEKFIV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 198 MANSGLFSIISLFILVSSYAVILISLRKHSAEG--------RRKALSTCASHITVVILYFGPGAFIYMRPSSAFTEDK-- 267
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsr 232

                         250       260
                  ....*....|....*....|....
gi 1195666580 268 ------LVSVFYTVITPMLNPIVY 285
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 29-292 1.00e-30

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 116.41  E-value: 1.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  29 FLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVV 108
Cdd:cd15955     7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVC-HMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHPLLKLAC 187
Cdd:cd15955    87 ESGILLAMALDRYVAICHPLRHSSILTPQVLlGIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 188 TDTFMEKFIVMANSGLFSIISLFILVSSYAVILISL-RKHSAEGRRKALSTCASHITVVILYFGPGAFIYMRPSSAFTED 266
Cdd:cd15955   167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVA 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195666580 267 K----LVSVFYTVITPMLNPIVYTLRNTEM 292
Cdd:cd15955   247 PyvhiLLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 26-289 1.08e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 97.74  E-value: 1.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd00637     2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNVIDHYFCdlhPLLKL 185
Cdd:cd00637    82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDYGGY---CCCCL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASH------------ITVVILYF---G 250
Cdd:cd00637   151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLlcwL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195666580 251 PGAFIYMRPSSAFTEDKLVSVFYTVIT------PMLNPIVYTLRN 289
Cdd:cd00637   231 PYFILLLLDVFGPDPSPLPRILYFLALllaylnSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 27-296 8.60e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 81.07  E-value: 8.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNVIDHYFCDLHPllkla 186
Cdd:cd14967    84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--------PPLVGWRDETQPSVVDCE----- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 187 CTDTFMEKFIVMANSGLFsIISLFILVSSYAVILISLRKHsaegrRKALSTCAshITVVILYFGPGAFIYMRPSSAFTED 266
Cdd:cd14967   151 CEFTPNKIYVLVSSVISF-FIPLLIMIVLYARIFRVARRE-----LKAAKTLA--IIVGAFLLCWLPFFIIYLVSAFCPP 222

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195666580 267 KLVSVFYTVITPML-------NPIVYTLRNTEMKNAI 296
Cdd:cd14967   223 DCVPPILYAVFFWLgylnsalNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 34-296 6.43e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 58.76  E-value: 6.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEIILL 113
Cdd:cd14969    12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 114 VVMAYDRYVAICKPLHYMIIMSRQVChMLVAGSWLGGLIHSIiqiiitipLPFCGPNVI----DHYFCDLHPLLKLACTD 189
Cdd:cd14969    92 AALAFERYLVIVRPLKAFRLSKRRAL-ILIAFIWLYGLFWAL--------PPLFGWSSYvpegGGTSCSVDWYSKDPNSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 190 TFMekFIVMAnsgLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCAS-----------HITVVILYF----GPGAF 254
Cdd:cd14969   163 SYI--VSLFV---FCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKrtkkaekkvakMVLVMIVAFliawTPYAV 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580 255 IYMrpSSAFTEDKLVSVFYTVITPML-------NPIVYTLRNTEMKNAI 296
Cdd:cd14969   238 VSL--YVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 37-151 1.42e-09

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 57.81  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  37 LLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEIILLVVM 116
Cdd:cd15336    15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAI 94

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195666580 117 AYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGL 151
Cdd:cd15336    95 SLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSL 129
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 27-295 5.93e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 52.99  E-value: 5.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15305     5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWlgglihsIIQIIITIPLPFCGPNVIDHYFCDLHPLLKl 185
Cdd:cd15305    85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIGLQDDEKVFVNGTCVLN- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 actdtfmEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPGAFI----YMRPSS 261
Cdd:cd15305   157 -------DENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFItnilSVLCKE 229

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195666580 262 AFTED---KLVSVFYTV--ITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15305   230 ACDQKlmeELLNVFVWVgyVSSGINPLVYTLFNKTYRRA 268
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 20-151 7.05e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 52.62  E-value: 7.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  20 EVQKLCFVLFLpvylaTLLGNGLIFVTVSISKTLHSPMYFFLSSLSlveicysstvapkfITDLLAEVKTISLKGCLTQI 99
Cdd:cd15196     3 EIAVLATILVL-----ALFGNSCVLLVLYRRRRKLSRMHLFILHLS--------------VADLLVALFNVLPQLIWDIT 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195666580 100 FFFH----------FFGVVEIIL----LVVMAYDRYVAICKPLHYMIImSRQVCHMLVAGSWLGGL 151
Cdd:cd15196    64 YRFYggdllcrlvkYLQVVGMYAssyvLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSL 128
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 28-295 1.06e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 51.93  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15052     6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLgglihsiIQIIITIPLPFCG----PNVIDHYFCDLhpl 182
Cdd:cd15052    86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWL-------ISIGISSPIPVLGiidtTNVLNNGTCVL--- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 lklactdtFMEKFIVMANSGLFsIISLFILVSSYAVILISLRKhsaegRRKALSTCASHITVVILYFGPGAFIYM----- 257
Cdd:cd15052   156 --------FNPNFVIYGSIVAF-FIPLLIMVVTYALTIRLLSN-----EQKASKVLGIVFAVFVICWCPFFITNIltglc 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195666580 258 RPSSAFTEDKLVSVFYTV--ITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15052   222 EECNCRISPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 32-147 2.27e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 51.30  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  32 VYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTI-SLKGCLTQIFFFHFFGVVEI 110
Cdd:cd15005    10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSA 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195666580 111 ILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15005    90 FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 27-225 3.23e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 50.71  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSiSKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKG-----CLTQIFF 101
Cdd:cd14978     5 YVLPVICIFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYPL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDLHP 181
Cdd:cd14978    84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1195666580 182 LLKlacTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRK 225
Cdd:cd14978   164 LRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRK 204
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 26-295 8.96e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 49.56  E-value: 8.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAevKTISLKGCLtqifFFHFF 105
Cdd:cd14968     4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLG--LPTNFHGCL----FMACL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVV----EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNViDHYFCDLHP 181
Cdd:cd14968    78 VLVltqsSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFGWNN-GAPLESGCG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 LLKLAC------TDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRK----HSAEGRRK------------------ 233
Cdd:cd14968   149 EGGIQClfeeviPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQieslLRSRRSRStlqkevkaakslaiilfl 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195666580 234 -ALSTCASHITVVILYFGPGAFIymrPSSAFtedkLVSVFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd14968   229 fALCWLPLHIINCITLFCPECKV---PKILT----YIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 24-148 9.20e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 49.37  E-value: 9.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP----------KFITDLLAEVKT-ISL 92
Cdd:cd15317     2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfsmirtvetcWYFGDLFCKFHTgLDL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195666580  93 KGCLTQIFffhffgvveiiLLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15317    82 LLCTTSIF-----------HLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 28-147 9.82e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 49.02  E-value: 9.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIF------F 101
Cdd:cd15103     6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15103    86 ICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 24-295 1.06e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 49.03  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15063     2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIqiiitiplPFCGPNVIDHYFCDLHPL- 182
Cdd:cd15063    82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFP--------PLVGWNDGKDGIMDYSGSs 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 183 -LKLACTDTFMEKFIVMANSGLFSIISLFILVSSYAVIlislrkHSAEGRRKALSTCASHITVVILYFGPGAFIYMrpSS 261
Cdd:cd15063   154 sLPCTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIY------RAARMETKAAKTVAIIVGCFIFCWLPFFTVYL--VR 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195666580 262 AFTEDKLVSVFYTVI------TPMLNPIVYTLRNTEMKNA 295
Cdd:cd15063   226 AFCEDCIPPLLFSVFfwlgycNSALNPCIYALFSRDFRFA 265
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 27-147 1.31e-06

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 48.62  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKG--------CLTQ 98
Cdd:cd15350     5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDS 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580  99 IFFFHFFGvvEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15350    85 LFCLSLLG--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW 131
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 27-299 1.45e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 48.67  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKTISLKGCLTQIFFFHFF 105
Cdd:cd15306     5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLgglihsiIQIIITIPLPFCG----PNVIDHYFCDLHP 181
Cdd:cd15306    85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWL-------ISIGIAIPVPIKGietdVDNPNNITCVLTK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 182 llklactDTFMEkFIVMANSGLFsIISLFILVSSYAVILISLRKHSAEGRRKALSTCASHITVVILYFGPG-----AFIY 256
Cdd:cd15306   158 -------ERFGD-FILFGSLAAF-FTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFfitniTSVL 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195666580 257 MRPSSAFTEDKLVSVFYTV--ITPMLNPIVYTLRNTEMKNAIRMF 299
Cdd:cd15306   229 CDSCNQTTLQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAFGRY 273
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 27-295 1.56e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.44  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEiCYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd14972     3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNVIDHYFCDLHPLLKLA 186
Cdd:cd14972    82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVLCDQESCSPLGPGL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 187 CTDTFMekFIVMANSGLFSIISLFilvssYAVILISLRKHSAEGRRKALSTCASH--------ITVVI------LYFGPG 252
Cdd:cd14972   154 PKSYLV--LILVFFFIALVIIVFL-----YVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIvlgvflVCWLPL 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1195666580 253 AFIYMRPSSAFTEDKLVSVFYTVITPML-----NPIVYTLRNTEMKNA 295
Cdd:cd14972   227 LILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRA 274
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 27-295 1.60e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 48.39  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVK-TISLKGCLTQIFFFHFF 105
Cdd:cd15304     5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWlgglihsIIQIIITIPLPFCGPNVIDHYFCDLHPLLkl 185
Cdd:cd15304    85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFGLQDDSKVFKEGSCLL-- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 acTDtfmEKFIVMANSGLFsIISLFILVSSYAVILISLRKhSAEGRRKALSTCASHITVVILYFGP------GAFIYMRP 259
Cdd:cd15304   156 --AD---ENFVLIGSFVAF-FIPLTIMVITYFLTIKSLQQ-SISNEQKASKVLGIVFFLFVVMWCPffitnvMAVICKES 228

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195666580 260 SSAFTEDKLVSVFYTV--ITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15304   229 CNEVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSA 266
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 34-148 2.02e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 48.32  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEIILL 113
Cdd:cd15318    12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195666580 114 VVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15318    92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWL 126
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 26-148 2.92e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 47.73  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPK----------FITDLLAEVKT-ISLKG 94
Cdd:cd15312     4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYsmvrsvescwYFGDLFCKIHSsLDMML 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195666580  95 CLTQIFFFHFFGVveiillvvmayDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15312    84 STTSIFHLCFIAV-----------DRYYAVCDPLHYRTKITTPVIKVFLVISWS 126
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 28-147 8.47e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 46.47  E-value: 8.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGV 107
Cdd:cd15354     6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSL 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 108 VEIIL------LVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15354    86 ICISVvasmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 34-143 1.23e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.78  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPkfitdlLAEVKTISLKGCLTQIFFFHFFGV------ 107
Cdd:cd15064    12 LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP------LSAVYELTGRWILGQVLCDIWISLdvtcct 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1195666580 108 VEIILLVVMAYDRYVAICKPLHYMiiMSRQVCHMLV 143
Cdd:cd15064    86 ASILHLCVIALDRYWAITDAVEYA--HKRTPKRAAV 119
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 26-148 1.52e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 45.62  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPkfitdlLAEVKTISLKGCLTQIF--FFH 103
Cdd:cd15055     4 YIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIETCWYFGDTFckLHS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580 104 FFGV----VEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15055    78 SLDYiltsASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF 126
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 32-148 1.54e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 45.50  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  32 VYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEII 111
Cdd:cd15050    10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195666580 112 LLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15050    90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWL 126
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 27-148 2.83e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 44.92  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLS-------LVEICYSSTVAPKFITDLlaevktislKGCLTQI 99
Cdd:cd15069     5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAaadvavgLFAIPFAITISLGFCTDF---------HSCLFLA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580 100 FFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15069    76 CFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWV 124
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 36-151 2.93e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 44.96  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  36 TLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEIILLVV 115
Cdd:cd15074    14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTA 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1195666580 116 MAYDRYVAICKPlHYMIIMSRQVCHMLVAGSWLGGL 151
Cdd:cd15074    94 ISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYAL 128
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 28-148 4.30e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.40  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQifffHFFGV 107
Cdd:cd15351     6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195666580 108 VEIIL----------LVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15351    82 IDTMIcssvvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL 132
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 27-148 4.72e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 44.10  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTvAPKFITDLLAEVKTISLKGCltQIFFF--HF 104
Cdd:cd15079     5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGC--QIYAFlgSL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1195666580 105 FGVVEIILLVVMAYDRYVAICKPLHyMIIMSRQVCHMLVAGSWL 148
Cdd:cd15079    82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWL 124
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 27-148 5.75e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 43.86  E-value: 5.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15083     5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15083    85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL 126
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 28-147 1.25e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 42.97  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFI-------TDLLAEVKTISLKGCLTQIF 100
Cdd:cd15353     6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVvitllngNDTDAQSFTVNIDNVIDSVI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195666580 101 FFHFfgVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15353    86 CSSL--LASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 28-148 1.73e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 42.57  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGV 107
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195666580 108 VEIIL------LVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15352    86 ICISLvasicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
 24-149 1.75e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 42.26  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15329     2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLG 149
Cdd:cd15329    82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLL 127
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 20-151 2.12e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.11  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  20 EVQKLCFVLFLpvylaTLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSS-TVAPKFITDLlaevkTISLKGCLTQ 98
Cdd:cd15387     3 EVTVLALILFL-----ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGPDFL 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195666580  99 IFFFHFFGVVEII----LLVVMAYDRYVAICKPLHYmiiMSRQVCHMLVAGSWLGGL 151
Cdd:cd15387    73 CRLVKYLQVVGMFastyMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSL 126
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
 40-296 3.80e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 41.46  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  40 NGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLkgcLTQIFFFHFFgVVEIILLVVMAYD 119
Cdd:cd15962    18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL---ITVGFLVASF-TASVSSLLAITVD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 120 RYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNVIDHYF-CDL-HPLLKLACT---DTFMEK 194
Cdd:cd15962    94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGL--------LPVLGWNCLEERAsCSIvRPLTKSNVTllsASFFFI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 195 FIVMansgLFSIISLFILVSSYAViLISLRKHSAE-----GRRKALSTCAshitVVILYFGPGAF---IYMRPSSafTED 266
Cdd:cd15962   166 FILM----LHLYIKICKIVCRHAH-QIALQQHFLTashyvATKKGVSTLA----IILGTFGASWLpfaIYCVVGD--HEY 234

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195666580 267 KLVSVFYTVI----TPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15962   235 PAVYTYATLLpatyNSMINPIIYAYRNQEIQRSM 268
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
 24-148 4.01e-04

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 41.36  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFI-TDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15308     2 AALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVySEFQGGVWTLSPVLCDALMTMD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYmiiMSRQVCH---MLVAGSWL 148
Cdd:cd15308    82 VMLCTASIFNLCAISVDRFIAVSVPLNY---NRRQGSVrqlLLISATWI 127
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 28-233 6.65e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 40.80  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLaEVKTISLK--GCLTQIFFFHFF 105
Cdd:cd14979     6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW-WQYPWAFGdgGCKLYYFLFEAC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDH---YFCDLhpl 182
Cdd:cd14979    85 TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVpdsAVCTL--- 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195666580 183 lklaCTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRK--HSAEGRRK 233
Cdd:cd14979   162 ----VVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSmrNIKKGTRA 210
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 25-147 7.46e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 40.76  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  25 CFVLFLpvYLATLLGNGLIFVTVSISKTLHSPMY-FFLSSLSLVEICYSSTVAPkfiTDLLAEVKTISLKGCLTQIF--F 101
Cdd:cd15320     6 CFLSVL--ILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMP---WKAVAEIAGFWPFGSFCNIWvaF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15320    81 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAW 126
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
 27-148 8.41e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.21  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15215     4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15215    84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWI 125
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
 28-151 8.64e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 40.14  E-value: 8.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTI-SLKGCLTQIFFFHFFG 106
Cdd:cd15212     6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACFG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMiiMSRQVCHMLVAGSWLGGL 151
Cdd:cd15212    86 IVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTAL 128
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
 27-295 8.94e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 40.11  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15060     5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMS-RQVCHMLVAGsWLGGLIHSIIqiiitiplPFCGPNVIDHYFCDLHPllkl 185
Cdd:cd15060    85 TASILNLCAIALDRYWAIHDPINYAQKRTlKRVLLMIVVV-WALSALISVP--------PLIGWNDWPENFTETTP---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 186 aCTDTFMEKFIVMANSGLFsIISLFILVSSYAVILISLRKhsaegRRKALSTCASHITVVILYFGPGAFIYM-RP--SSA 262
Cdd:cd15060   152 -CTLTEEKGYVIYSSSGSF-FIPLLIMTIVYVKIFIATSK-----ERRAARTLGIIMGVFVVCWLPFFLMYViLPfcETC 224

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195666580 263 FTEDKLVS--VFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15060   225 SPSAKVVNfiTWLGYVNSALNPVIYTIFNLDFRRA 259
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 27-148 9.16e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 40.12  E-value: 9.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15012     4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15012    84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL 125
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
 27-130 1.16e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 39.78  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPkfITDLLAEVKTISLKGCLTQIFFFH--F 104
Cdd:cd15333     9 VLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIWLSSdiT 86

                          90       100
                  ....*....|....*....|....*.
gi 1195666580 105 FGVVEIILLVVMAYDRYVAICKPLHY 130
Cdd:cd15333    87 CCTASILHLCVIALDRYWAITDAVEY 112
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 36-295 1.17e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 40.05  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  36 TLLGNGLIFVTVSISKTL-HSPMYFFLSSLSLVEICySSTVAPKFITDLL-----AEVKTIslkgCLTQIFFFHFFGVVE 109
Cdd:cd15104    13 IITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFL-VGLAIPGLATDELlsdgeNTQKVL----CLLRMCFVITSCAAS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 110 IILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLgglihsIIQIIITIPLPFCGPNVIDHY-FCDLHPLLKLact 188
Cdd:cd15104    88 VLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWL------YSGLIGFLPLISPQFQQTSYKgKCSFFAAFHP--- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 dtfmEKFIVMANSGLFSiiSLFILVSSYAVILISLRKHSAEGRR------------------KALSTCASHITVVILYFG 250
Cdd:cd15104   159 ----RVLLVLSCMVFFP--ALLLFVFCYCDILKIARVHSRAIYKvehalarqihprrtlsdfKAARTVAVLIGCFLLSWL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195666580 251 PgAFIYMRPSSAFTEDKLVSV------FYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15104   233 P-FQITGLVQALCDECKLYDVledylwLLGLCNSLLNPWIYAFWQKEVRRA 282
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 24-151 1.19e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.04  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15392     2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPVVNYLQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHymIIMSRQVCHMLVAGSWLGGL 151
Cdd:cd15392    82 AVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFAL 128
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 28-295 1.32e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 39.64  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVY-LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITdllaeVKTISLKGCLTQIF--FFHF 104
Cdd:cd15053     5 LFLLLLpLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVY-----VEVNGGKWYLGPILcdIYIA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 105 FGVV----EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIIQIIITIPLPFCGPNVIDHYFCDlh 180
Cdd:cd15053    80 MDVMcstaSIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPD-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 181 pllklactdtfmekFIVManSGLFS-IISLFILVSSYAVILISLRKhsaegRRKALSTCA---------------SHIT- 243
Cdd:cd15053   158 --------------FIIY--SSISSfYIPCIVMLLLYYRIFRALRR-----EKKATKTLAivlgvflfcwlpfftLNILn 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195666580 244 -VVILYFGPGAFIYMRPSSAFTedklvsvFYTVITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15053   217 aICPKLQNQSCHVGPALFSLTT-------WLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 27-148 1.39e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 39.50  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPkfITdLLAEVKTISLKG---CLTQIFFFH 103
Cdd:cd14993     5 VLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMP--LT-LLENVYRPWVFGevlCKAVPYLQG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd14993    82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV 126
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 36-148 1.47e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.64  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  36 TLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEvktiSLKG---CLTQIFFFHFFGVVEII 111
Cdd:cd15065    13 AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTfAVVNDLLGY----WLFGetfCNIWISFDVMCSTASIL 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195666580 112 LLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15065    89 NLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWI 125
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 34-147 1.65e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 39.34  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMY-FFLSSLSLVEICYSSTVAPKFITDLLAEVKTISlKGCLTQIFFFHFFGVVEIIL 112
Cdd:cd15057    12 LLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASILN 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195666580 113 LVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSW 147
Cdd:cd15057    91 LCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAW 125
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 27-130 1.67e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 39.55  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15307     5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                          90       100
                  ....*....|....*....|....
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHY 130
Cdd:cd15307    85 TASIMHLCTISVDRYLSLRYPMRF 108
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 24-295 1.68e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 39.26  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLpVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFIT-DLLAEVKTISLKGCLTqiffF 102
Cdd:cd15067     2 LGVVLSL-FCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILhEMTGGYWLFGRDWCDV----W 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 103 HFFGVV----EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLgglihsiiqiiITIPLPFcgPNVIDHYFCD 178
Cdd:cd15067    77 HSFDVLastaSILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI-----------CSALISF--PAIAWWRAVD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 179 LHPLLKLACTdtFMEKFIVMANSGLFSI-ISLFILVSSYAVILISlrkhsAEGRRKALSTCASHITVVILYFGPgaFIYM 257
Cdd:cd15067   144 PGPSPPNQCL--FTDDSGYLIFSSCVSFyIPLVVMLFTYYRIYRA-----AAKEQKAAKTLGIVMGVFILCWLP--FFVT 214

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195666580 258 RPSSAFTEDKLVSVFYTV---------ITPMLNPIVYTLRNTEMKNA 295
Cdd:cd15067   215 NILIGFCPSNCVSNPDILfplvtwlgyINSGMNPIIYACSSRDFRRA 261
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 32-151 2.06e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 39.28  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  32 VYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSlveicysstvapkfITDLLAEVKTIslkgcLTQI---FFFHFFG-- 106
Cdd:cd14986    10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLA--------------IADLVVAFFTV-----LTQIiweATGEWVAgd 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1195666580 107 ----------VVEII----LLVVMAYDRYVAICKPLHYMiiMSRQVCHMLVAGSWLGGL 151
Cdd:cd14986    71 vlcrivkylqVVGLFastyILVSMSLDRYQAIVKPMSSL--KPRKRARLMIVVAWVLSF 127
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 27-148 2.37e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 39.03  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15979     5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15979    85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWL 126
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 27-148 2.51e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 38.76  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITdlLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15068     5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15068    83 QSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 124
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 37-296 2.86e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 38.56  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  37 LLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKtISLKGCLTQIFFFHFFGVVEIILLVV 115
Cdd:cd15073    15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPfSAASDLHGSWK-FGYAGCQWYAFLNIFFGMASIGLLTV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 116 MAYDRYVAICKPLHYMIIMSRQVCHMLVAGsWLGGLIHSIiqiiitipLPFCGPNVIDHYFCDLHPLLKLACTDTFMEKF 195
Cdd:cd15073    94 VAVDRYLTICRPDLGRKMTTNTYTVMILLA-WTNAFFWAA--------MPLVGWASYALDPTGATCTINWRKNDSSFVSY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 196 IvMANSGLFSIISLFILVSSYAVILISLRKHSAEGRRKALS---TCASHIT----VVILYF----GPGAFIYMrpSSAFT 264
Cdd:cd15073   165 T-MSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNidwTDQNDVTkmsvIMIVMFlvawSPYSIVCL--WASFG 241

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195666580 265 EDKLVSVFYTVITPML-------NPIVYTLRNTEMKNAI 296
Cdd:cd15073   242 EPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
 26-130 3.16e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 38.58  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  26 FVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICysSTVAPKFITDLLAEvKTISLKGCLTQIFFFHFF 105
Cdd:cd15905     2 FWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLL--TGVALPFIPGMSNE-SRRGYHSCLFVYVAPNFL 78

                          90       100
                  ....*....|....*....|....*
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHY 130
Cdd:cd15905    79 FLSFLANLLMVHYERYLCIVYPLQY 103
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 24-148 3.78e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 38.39  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAP-KFITDLLAEVKTISLKGCLTQIFFF 102
Cdd:cd15328     2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPlSLVHELSGRRWQLGRSLCQVWISFD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15328    82 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWA 127
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 27-128 5.06e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 37.92  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLS----LVEICYSSTVAPKFITDLLAEVKTIslkgCLTQIFFF 102
Cdd:cd15084    15 VLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAvadlLVTLFGSSVSFSNNIVGFFVFGKTM----CEFEGFMV 90

                          90       100
                  ....*....|....*....|....*.
gi 1195666580 103 HFFGVVEIILLVVMAYDRYVAICKPL 128
Cdd:cd15084    91 SLTGIVGLWSLAILAFERYLVICKPM 116
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
 94-148 5.39e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 37.83  E-value: 5.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195666580  94 GCLTQIFFFHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVChMLVAGSWL 148
Cdd:cd15075    72 GCVLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHAL-AGIASSWL 125
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 27-249 6.52e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 37.65  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLA-EVKTISLKGCLTQIFFFHFF 105
Cdd:cd14997     5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWArEPWLLGEFMCKLVPFVELTV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 106 GVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitiPLPFCGPNVIDHYFCDLHPLLKL 185
Cdd:cd14997    85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS-------PVLFITEFKEEDFNDGTPVAVCR 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1195666580 186 ACTDTFMEKFIVMANSGLFSIISLFILVSSYAVILISLRKHSA--EGRRKALSTCASH---------ITVVILYF 249
Cdd:cd14997   158 TPADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPAleSRRADAANRHTLRsrrqvvymlITVVVLFF 232
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 24-143 6.66e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 37.52  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  24 LCFVLFLPVYLaTLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFH 103
Cdd:cd15085     3 LSFLMFLNATF-SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195666580 104 FFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLV 143
Cdd:cd15085    82 YFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLL 121
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 34-148 6.69e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 37.70  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGVVEIILL 113
Cdd:cd15051    12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNL 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1195666580 114 VVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15051    92 FAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWV 126
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
 28-148 7.56e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 37.36  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPkfitdLLAEVkTISLKGCLTQIF------F 101
Cdd:cd15066     5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMT-----FNASV-EITGRWMFGYFMcdvwnsL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1195666580 102 FHFFGVVEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15066    79 DVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWI 125
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 28-295 7.90e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 37.34  E-value: 7.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  28 LFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFGV 107
Cdd:cd15061     5 FLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 108 VEIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNviDHYFCDLHpllklAC 187
Cdd:cd15061    85 ASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITS--------PPLVGPS--WHGRRGLG-----SC 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 188 TDTFMEKFIVMANSGLFSIISLFILvssYAVILISlrkHSAEGRRKALSTCASHITVVILYFGPgaFIYMRPSSAFTEDK 267
Cdd:cd15061   150 YYTYDKGYRIYSSMGSFFLPLLLML---FVYLRIF---RVIAKERKTAKTLAIVVGCFIVCWLP--FFIMYLIEPFCDCQ 221

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195666580 268 LVSVFYTVIT------PMLNPIVYTLRNTEMKNA 295
Cdd:cd15061   222 FSEALSTAFTwlgyfnSVINPFIYAFYNKDFRRA 255
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
 27-148 8.33e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 37.12  E-value: 8.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  27 VLFLPVYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFITDLLAEVKTISLKGCLTQIFFFHFFG 106
Cdd:cd15008     4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195666580 107 VVEIILLVVMAYDRYVAICKPLHYMIimSRQVCHMLVAGSWL 148
Cdd:cd15008    84 GVQIYVLLSICVDRFYTIVYPLSFKV--SREKAKKMIAASWL 123
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 32-148 8.85e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 37.06  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  32 VYLATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFItdLLAEVKTISLKGCLTQIFFFHFFGVVEII 111
Cdd:cd15070    10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFTHASIM 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1195666580 112 LLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWL 148
Cdd:cd15070    88 SLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWL 124
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
 34-296 9.43e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.13  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580  34 LATLLGNGLIFVTVSISKTLHSPMYFFLSSLSLVEICYSSTVAPKFItDLLAEVKTISlkgclTQIFFFHFFGV-----V 108
Cdd:cd15341    13 LCILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLASVVFACSFV-DFHVFHGVDS-----SAIFLLKLGGVtmsftA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 109 EIILLVVMAYDRYVAICKPLHYMIIMSRQVCHMLVAGSWLGGLIHSIiqiiitipLPFCGPNVIDhyfcdlhplLKLACT 188
Cdd:cd15341    87 SLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAY--------LPLMGWNCCP---------LNSPCS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195666580 189 DTFmeKFI---VMANSGLFSIISLFILVSSYAVILISLRKHSA--------EGRRKA--------LSTCASHITVVILYF 249
Cdd:cd15341   150 ELF--PLIpndYLLSWLLLVAILLSGIIYTYGHVLWKAHKHVVymekhqdqQGPGNArmrldvrlAKTLGLVLAVLLICW 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195666580 250 GPgAFIYMRPSSAFT-EDKLVSVF-----YTVITPMLNPIVYTLRNTEMKNAI 296
Cdd:cd15341   228 SP-VLALMMHSLFTSlSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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