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Conserved domains on  [gi|1191906038|ref|XP_020957812|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3 [Sus scrofa]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 170-375 6.71e-139

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 394.03  E-value: 6.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 249
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQphKIKQKPTTGLLAITLALHLCDL 329
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1191906038 330 VHIAGFGYPDAQNKKESIHYYEQITIKSMAWSGHNVSQEALAIKRM 375
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 170-375 6.71e-139

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 394.03  E-value: 6.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 249
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQphKIKQKPTTGLLAITLALHLCDL 329
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1191906038 330 VHIAGFGYPDAQNKKESIHYYEQITIKSMAWSGHNVSQEALAIKRM 375
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 136-380 7.23e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.47  E-value: 7.23e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 136 SAYELPYgtKGSEDLLLRVLAITSysipesIQRLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGS 215
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 216 KTTMRLFYPESA---HFNPKVEDN---PDTLLVLVAFKAMDFHWIESILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 286
Cdd:pfam00777  88 KTTLRTMNPESAidsKYGNLGFSHprdPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 287 NPFFMEIAADKLLRLPMQQPHkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaQNKKESIHYYEQITIKSM-AWSGHNV 365
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGgFYGVHDM 241

                         250
                  ....*....|....*
gi 1191906038 366 SQEALAIKRMLEIGA 380
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 170-375 6.71e-139

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 394.03  E-value: 6.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 249
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQphKIKQKPTTGLLAITLALHLCDL 329
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1191906038 330 VHIAGFGYPDAQNKKESIHYYEQITIKSMAWSGHNVSQEALAIKRM 375
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 170-375 1.17e-109

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 319.62  E-value: 1.17e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKvEDNPDTLLVLVAFKAM 249
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPE-EYDSDWLLVLVPFKSM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQpHKIKQKPTTGLLAITLALHLCD 328
Cdd:cd23967    80 DLLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1191906038 329 LVHIAGFGYPDAQNKKeSIHYYEQITIKSMAWS-GHNVSQEALAIKRM 375
Cdd:cd23967   159 EVDIAGFGYDPSDPNA-PLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 170-375 1.14e-79

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 243.50  E-value: 1.14e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKVEDnPDTLLVLVAFKAM 249
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYD-PNTTVVLIPFKPH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQP-HKIKQKPTTGLLAITLALHLCD 328
Cdd:cd23984    80 DLRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPkEKKPKHPTTGIIAITLALHICN 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1191906038 329 LVHIAGFGYpDAQNKKESIHYYEQITIKSMAWSG-HNVSQEALAIKRM 375
Cdd:cd23984   160 EVHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 136-380 7.23e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.47  E-value: 7.23e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 136 SAYELPYgtKGSEDLLLRVLAITSysipesIQRLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGS 215
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 216 KTTMRLFYPESA---HFNPKVEDN---PDTLLVLVAFKAMDFHWIESILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 286
Cdd:pfam00777  88 KTTLRTMNPESAidsKYGNLGFSHprdPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 287 NPFFMEIAADKLLRLPMQQPHkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaQNKKESIHYYEQITIKSM-AWSGHNV 365
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGgFYGVHDM 241

                         250
                  ....*....|....*
gi 1191906038 366 SQEALAIKRMLEIGA 380
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 171-375 1.10e-63

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 202.66  E-value: 1.10e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfnPKV--EDNPDTLLVLVAFKA 248
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKSeqEYDPTSLFVAVLFKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 249 MDFHWIESILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPmqQPHKI-----KQKPTTGLLAI 320
Cdd:cd23983    79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYP--EPQSRlwgwdKNVPTLGVTAV 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191906038 321 TLALHLCDLVHIAGFGYpDAQNKKESIHYYEQITIKSM-AWSGHNVSQEALAIKRM 375
Cdd:cd23983   157 VLATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMnTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 171-375 6.04e-57

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 185.13  E-value: 6.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPKVEDNpDTLLVLVAFKAMD 250
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEK-DSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 251 FHWIESIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLPMQQPHKIKQK-PTTGLLAITLALHLCD 328
Cdd:cd23981    81 FKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNCD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1191906038 329 LVHIAGFGYpDAQNKKESIHYYEQITIKSM--AWSgHNVSQEALAIKRM 375
Cdd:cd23981   161 EVAVAGFGY-DMNTPNAPLHYYETIKMSAIkeSWT-HNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 170-382 8.80e-49

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 166.30  E-value: 8.80e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfnpkVEDNPDTLLVLVAFKAM 249
Cdd:cd23966    76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA-----VDLDPGVHLVLVPFKVL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFFMEIAADKLLrlpmqqpHKIKQKPTTGLLAITLALHLCDL 329
Cdd:cd23966   151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 330 VHIAGFGypdAQNKKESIHYYEQitiksMAWSG-------HNVSQEALAIKRMLEIGAVK 382
Cdd:cd23966   222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 121-382 1.41e-44

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 155.88  E-value: 1.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 121 PIFLQLKDYF--WVKTPSAYELPYGTKG-SEDLLLRVLAITSYSIPESI-----QRLKCRRCVVVGNGHRLRNSLLGEAI 192
Cdd:cd23964    24 KVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVERLLRNLNLTSSRYMfvlrgGRPRCIRCAVVGNGGILNGSGKGKEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 193 NKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfNPKVEDNP---DTLLVLVAFKAMDFHWIESILSDKKRVR---K 266
Cdd:cd23964   104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLH-NSLLKHVPqdkDTKYLFIPFKIRDYDYLDAVLSGKPVPDgcdK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 267 GFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRlpmqqpHKIKQKPTTGLLAITLALHLCDLVHIAGFGYpdaqNKKES 346
Cdd:cd23964   183 GKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLN------SSTSYRPTTGALMLLTALHTCDQVSVYGFGY----DPRFS 252

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1191906038 347 IHYYEQiTIKSMAWSG--HNVSQEALAIKRMLEIGAVK 382
Cdd:cd23964   253 LHYYDK-TFVKFTVFYanHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 174-375 3.40e-39

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 138.65  E-value: 3.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 174 CVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHF---NPKVEDNPDTLLVLVAFKAMD 250
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrGPRCGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 251 FHWIESILSDKKRVRKgfwKQPPLIwdVNPKQIRILNpFFMEIaADKLLRLPMQQPHkikqKPTTGLLAITLALHLCDLV 330
Cdd:cd19952    81 AAAADFKRLKRRKKRH---DNAVLL--LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQLCDSV 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1191906038 331 HIAGFGYPDAQNKKESIHYYEQITIKSMAWSgHNVSQEALAIKRM 375
Cdd:cd19952   150 DLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 170-351 3.29e-33

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 125.38  E-value: 3.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 170 KCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfnpkvEDNPDTLLVLVAFKAM 249
Cdd:cd23980    80 SCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFKTL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWIESILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLrlpmqQPHkiKQKPTTGLLAITLALHLCDL 329
Cdd:cd23980   155 DLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-----QGH--GRYPSTGILSVIFSLHVCDE 225

                         170       180
                  ....*....|....*....|..
gi 1191906038 330 VHIAGFGypdAQNKKESIHYYE 351
Cdd:cd23980   226 VDLYGFG---ADSKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 164-352 1.87e-32

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 123.06  E-value: 1.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 164 ESIQRLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFNPkvednPDTLLVL 243
Cdd:cd23979    73 RSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP-----ANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 244 VAFKAMDFHWIESILSDKKrVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLRlpmqqpHKiKQKPTTGLLAITLA 323
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQ-IRFTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDRWTE------HH-GRYPSTGMLVLFFA 218

                         170       180
                  ....*....|....*....|....*....
gi 1191906038 324 LHLCDLVHIAGFGypdAQNKKESIHYYEQ 352
Cdd:cd23979   219 LHVCDEVNVYGFG---ADSRGNWHHYWEN 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 172-382 1.89e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 109.27  E-value: 1.89e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 172 RRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTM---------RLFYPESAHFNPKV-----EDNP 237
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsilkRRYNSLKKNRDRDKflnrlKEYN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 238 DTLLVLVAFkamdfhwiesilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRlpmqqpHKIKQKPTTGL 317
Cdd:cd23963   144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKR------RGLEKRPSTGL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191906038 318 LAITLALHLCDLVHIAGFgYP---DAQNKKESIHYYEQITIKSMAWSgHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23963   206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 171-351 2.42e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 104.45  E-value: 2.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTmrlFYPESAH-------------FNpKVEDNP 237
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHsitsslmilqkrgFK-NIPQDK 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 238 DTLLVLVAFKAMDFHWIESILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFFMEIAADKLLRLP-MQQPHKIKQKP 313
Cdd:cd23973   159 DIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLRSKtLKGKYWAIYRP 238

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1191906038 314 TTGLLAITLALHLCDLVHIAGFGYPDAQnkKESIHYYE 351
Cdd:cd23973   239 TTGAFLLLTALHLCDTVSAYGFITEDYR--KYPDHYYD 274
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 172-375 3.24e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.42  E-value: 3.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 172 RRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL-----FYPESAHFNPKVEDNPDTLLVlvaF 246
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLV---W 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 247 KAMDFHwiesilsdkkRVRKGFWKQPPliWDVNPKQIR-----------ILNPFFMEIAADKLLRLpmqQPHKIKQK-PT 314
Cdd:cd23968   123 DPSSYN----------VNLEKWYKKPD--FDFFPNYIKyrrrhpeepfyLIDPRFLWRLWDILQEY---TPEKIKPNpPS 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191906038 315 TGLLAITLALHLCDLVHIAGFGYPDAQNKKEsiHYYEQITIKSM---AWsgHNVSQEALAIKRM 375
Cdd:cd23968   188 SGFIGIVLMLHLCDWVDVYEYVPSVRQTDRC--HYYDVEKDLACtlgAW--HPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 171-352 9.47e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 92.69  E-value: 9.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFypesAHFN-PKVEDNPDTLLVLVAFKAM 249
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 250 DFHWiesiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfFMEIAADKLLRLPMQQP-HKIKQKPTTGLLAITLAL 324
Cdd:cd23965    77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSrIKSGTWLSTGWFTMLLAL 150

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1191906038 325 HLCDLVHIAGFGYPD--AQNKKESI--HYYEQ 352
Cdd:cd23965   151 DVCDEIKVYGMVPENycREHPNSKVpyHYYEP 182
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 125-351 8.10e-21

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 90.92  E-value: 8.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 125 QLKDYFWVKTPSAYELPYGTKGSEDLLlrvlaiTSYSIPESIQRLKcrRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNA 204
Cdd:cd23985     7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPLG--RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 205 PVAGYEGDVGSKTTMRLFYP-----ESAHFnpkVEDNPDTLLVLVAFKAMDFH-----WIES----ILSDKKRVRKgfwk 270
Cdd:cd23985    79 PTAGFQQDVGTKTTIRLINSqlvttEKHKF---LKDSLYNEGILIVWDPAPYHsdipeWYKNpdynFFENYKTYRR---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 271 qppliwdVNPKQ-IRILNPFF--------MEIAADKLLRLPmqqphkikqkPTTGLLAITLALHLCDLVHIAGFgYPdAQ 341
Cdd:cd23985   152 -------LNPNQpFYILHPQMqwelwdiiQENSPEEIQPNP----------PSSGMLGIILMMTLCDQVDVYEF-LP-SK 212

                         250
                  ....*....|
gi 1191906038 342 NKKESIHYYE 351
Cdd:cd23985   213 RKTDVCHYYQ 222
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 171-382 1.19e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 91.35  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTmrlFYPESAH--FN-------------PKVED 235
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS---FYTFSTNtlMNslrayagvgfngpPQSKE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 236 ---------NPDTLLVLVAfkamdfhwIESILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFFMEIAADKLLRLP-M 303
Cdd:cd23974   161 tryiflpdhDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPiL 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191906038 304 QQPHKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAQnkKESIHYYEQITIKSMAWSGHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23974   230 NTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPDYG--KYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 136-382 1.36e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 91.04  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 136 SAYELPYGTKG--SEDL--LLRVLAITSYS--IPESIQRLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGY 209
Cdd:cd23972    41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 210 EGDVGSKTTmrlFYpesaHFNPKVEDNPdtllvLVAFKAMDFH-----------WIESILSDKKRVRKGFWKQP-PLIWD 277
Cdd:cd23972   121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 278 ------------VNPKQIRILNPFFMEIAADKLLR---LPMQQPHKIkqKPTTGLLAITLALHLCDLVHIAGFGYPDAQn 342
Cdd:cd23972   189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLKsklLNTHYGHLY--MPSTGALMLLTALHTCDQVSAYGFITSNYW- 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1191906038 343 kKESIHYYEQITIKSMAWSGHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23972   266 -KFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 172-385 6.85e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 88.63  E-value: 6.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 172 RRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSK---TTMrlfypesahfNPKVednpdtllVLVAFKA 248
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKsnlTTM----------NPSV--------IPHAYGD 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 249 MDF-HWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNpffmEIAADKLLRLPMQQP-----HKIK----------QK 312
Cdd:cd23969   127 LVNaTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN----EIILKHKLNVKTAYPplrlnHAIRgywlttkfriKR 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191906038 313 PTTGLLAITLALHLCDLVHIAGFgYP---DAQNKKESIHYYEQITIKSMAwSGHNVSQEALAIKRMLEIGAVKNLT 385
Cdd:cd23969   203 PSTGLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 172-382 1.79e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 84.75  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 172 RRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMrlfypesAHFNPKVEDNPDTLLVLVAFKAmdf 251
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-------TTFNPSILEKYYNNLLTIQDRN--- 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 252 hwieSILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLP-----MQ-------QPHKIKQKPTTGLLA 319
Cdd:cd23970   139 ----NFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAwpgniMQhvnrywkTKHLSPKRLSTGILM 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191906038 320 ITLALHLCDLVHIAGF-GYPDAQNKKE-SIHYYEQITIK-SMAWS-GHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23970   215 YTLASAICEEIHLYGFwPFGFDPTGTPlPYHYYDKKGTKfTTKWQeSHQLPAEFVLLYKMHGAGVLK 281
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 120-375 8.88e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 79.50  E-value: 8.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 120 QPIFLQLKDYFWVKTPSAYELPYGTKGSEDLLLRvlaitsysIPES-IQRLKCRRCVVVGNGHRLRNSLLGEAINKYDVV 198
Cdd:cd23986     5 QELLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSkLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 199 IRLNNAPVAGYEGDVGSKTTMRLFYPE-----SAHFNpkveDNP---DTLLVL---VAFKAMDFHWIE----SILSDKKR 263
Cdd:cd23986    77 LRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHFI----DSSlykDVILVAwdpAPYSANLHKWYKkpdyNLFTPYVQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 264 VRKGFWKQPPLIwdVNPKQIRILNPFFMEIAADKLlrlpmqQPHkikqKPTTGLLAITLALHLCDLVHIagFGYPDAQNK 343
Cdd:cd23986   153 YRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QPN----PPSSGFIGILIMMSMCREVHV--YEYIPSVRQ 218

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1191906038 344 KESIHYYEQITIKSMAWSG-HNVSQEALAIKRM 375
Cdd:cd23986   219 TDLCHYHERYYDAACTLGAyHPLLYEKLLIQRM 251
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 153-382 1.07e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 76.53  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 153 RVLAITS--YSIPESIQRLKCRR---CVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSK---TTM----- 219
Cdd:cd23988    41 RTLNISQnlHSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKsdfITMnpsvv 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 220 -RLF-----YPESAHFNPKVEDNPDTLLVLVAF--KAMDFH--WI-ESILSDKKRVRKGFwkqPPLiwdvnpKQIRILNP 288
Cdd:cd23988   121 qRAFggfrnESDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRG 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 289 FFMEiaadkllrlpmqqpHKIK-QKPTTGLLAITLALHLCDLVHIAGF-GYP-DAQNKKESIHYYEQITIKSMAWSG-HN 364
Cdd:cd23988   192 YWLT--------------NKVNiKRPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHR 257

                         250
                  ....*....|....*...
gi 1191906038 365 VSQEALAIKRMLEIGAVK 382
Cdd:cd23988   258 MPLEFKTLNVLHNRGALK 275
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 173-382 3.34e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 71.90  E-value: 3.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 173 RCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAgYEGDVGSKTTM--------RLFYPE----SAHFNPKVEDNPDTL 240
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNlkkrRRPFVERMKVYGNAL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 241 LVLVAFkAMDFHWIESI-----LSDKKRvrkgfwKQPPLIWdvNPKQIRILNPFFMEiaadkllrlpmqqpHKIK-QKPT 314
Cdd:cd23971   145 LLLPAF-SYTSNTEPSLralytLEDFGS------PQKVLFF--NPEYLRNLSRYWKS--------------KGLKaRRLS 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191906038 315 TGLLAITLALHLCDLVHIAGFgYP---DAQNKKESIHYYEQITIKSmawSGHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23971   202 TGLMLVSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNVLPKK---GVHAMPEEFLRYLKLHSQGVLR 268
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 160-382 1.01e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 70.74  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 160 YSIPESIQRLKCRR---CVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMrlfypesAHFNPKVedn 236
Cdd:cd23987    50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-------VTMNPSV--- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 237 pdtllVLVAFK-AMDFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLRLP-MQQPHKIK---- 310
Cdd:cd23987   120 -----VQRAFEdLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPsLRLLHAVRgywl 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 311 ------QKPTTGLLAITLALHLCDLVHIAGF-GYPDAQNKKE-SIHYYEQITIKSMAWSG-HNVSQEALAIKRMLEIGAV 381
Cdd:cd23987   195 tnkvhiKRPTTGLLMYTLATRFCNRIHLYGFwPFPRDQNQNPvKYHYYDSLKYGYTSQASpHTMPLEFKALKNLHQQGAL 274


                  .
gi 1191906038 382 K 382
Cdd:cd23987   275 K 275
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 171-351 1.73e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.11  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfnpKVEDNPDTLLVLVAFKAMD 250
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 251 FhW--IESILSDKKRVRKGFWKQPPLI------WDVNPKQIRILNPFF-MEIAADKllrlpmQQPHKIKqkpTTGLLAIT 321
Cdd:cd23978    78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR------KKSHSWL---STGWFTMV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1191906038 322 LALHLCDLVHIAGFGYPD-----AQNKKESIHYYE 351
Cdd:cd23978   148 IAVELCDNVHVYGMVPPNycskrPTPKKMPYHYYE 182
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 172-382 5.58e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 68.63  E-value: 5.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 172 RRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEG-DVGSKTTM-------------------RLFYPESAHFNp 231
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNLvtanpsiisikyaklnerrKPFLETVSVYG- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 232 kvednpDTLLVLVAFK-----AMDFHwIESILSDKKRvrkgfwKQPPLIWdvNPKQIRILNPFFMEIAAdKLLRLpmqqp 306
Cdd:cd23991   144 ------DAFLLLPAFSyrsntALSFK-VYYTLEDFKA------KQKVIFF--HPIYLKHLAQFWRSKGV-QVYRL----- 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191906038 307 hkikqkpTTGLLAITLALHLCDLVHIAGFgYPDAQN---KKESIHYYEQITIKSmawSGHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23991   203 -------STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 171-221 1.31e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.03  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL 221
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 168-382 2.50e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 60.61  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 168 RLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVA-GYEGDVGSKTTMrlfypesAHFNPKVEDN--PDTLLVLV 244
Cdd:cd23989    60 QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQL-------VTANPSIIDKrfQNLLWSRK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 245 AF----KAMDFHWIE-SILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFFME----------IAADKLlrlpmqqphk 308
Cdd:cd23989   133 SFvesmKVYGRSYIYmPAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLRnvgkfwkskgVHAKRL---------- 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191906038 309 ikqkpTTGLLAITLALHLCDLVHIAGFgYP---DAQNKKESIHYYEQITIKSmawSGHNVSQEALAIKRMLEIGAVK 382
Cdd:cd23989   202 -----STGLFLVSAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNVLPDS---GFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 168-351 1.13e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 58.34  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 168 RLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfnpKVEDNPDTLLVlVAFK 247
Cdd:cd23976    12 KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 248 AMDFHWIESilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFFMeIAADKLLRLPMQQPHKIKQK-PTTGLLAITLAL 324
Cdd:cd23976    88 TVFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIAL 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1191906038 325 HLCDLVHIAGFGYPD--AQNKKESI--HYYE 351
Cdd:cd23976   165 ELCDRINVYGMVPPDfcRDPNHPSVpyHYYE 195
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 132-353 2.55e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 51.38  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 132 VKTPSAYELPY--GTKGSEDLLLRVLAITSYSIPESiqRLKCRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAG- 208
Cdd:cd23990    25 KNTPLGTKLKYevDTSGIYHINSEIFKMFPKDMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEk 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 209 YEGDVGSKTTMRLFYP----ESAH--------FNPKVEDNPDTLLVLVAF---KAMDFHW-IESILSDKKRVRKGFWKQP 272
Cdd:cd23990   103 YVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYENASVVLPAFyntRNTDVSIrVKYVLDDFESQQAVYYFHP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191906038 273 PLIWDVNpkqirilnpffmeiaadkllRLPMQQPHKIKqKPTTGLLAITLALHLCDLVHIAGF-GYP-DAQNKKESIHYY 350
Cdd:cd23990   183 QYLLNVS--------------------RFWLRQGVRAK-RISSGLMLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYY 241


                  ...
gi 1191906038 351 EQI 353
Cdd:cd23990   242 DNV 244
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 171-238 5.73e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 49.93  E-value: 5.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191906038 171 CRRCVVVGNGHRLRNSLLGEAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfnPKVEDNPD 238
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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