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Conserved domains on  [gi|1191887872|ref|XP_020950770|]
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zinc finger protein 787 isoform X2 [Sus scrofa]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-207 2.49e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191887872  74 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACSDCGKTFSQSSHLVQHRR--IHTGE--KPYACSE--CGKRFSWSS 142
Cdd:COG5048   259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191887872 143 NLMQHQRIHTGEKPYACPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 207
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-207 2.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191887872  74 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACSDCGKTFSQSSHLVQHRR--IHTGE--KPYACSE--CGKRFSWSS 142
Cdd:COG5048   259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191887872 143 NLMQHQRIHTGEKPYACPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 207
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-168 1.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.20e-06
                          10        20
                  ....*....|....*....|....*.
gi 1191887872 143 NLMQHQRIHTGEKPYACPDCGRSFTQ 168
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 156-204 9.84e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 9.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1191887872 156 PYACPDCGRSFTQSKSLAKHRRSHSGLKpfVCPRCGRGFSQPKSLARHL 204
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
ZnF_C2H2 smart00355
zinc finger;
73-95 3.72e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 3.72e-03
                           10        20
                   ....*....|....*....|...
gi 1191887872   73 YICNECGKSFSHWSKLTRHQRTH 95
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-207 2.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191887872  74 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACSDCGKTFSQSSHLVQHRR--IHTGE--KPYACSE--CGKRFSWSS 142
Cdd:COG5048   259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191887872 143 NLMQHQRIHTGEKPYACPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 207
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-213 7.20e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 7.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191887872  73 YICNECGKSFSHWSKLTRHQRTHTGERPNACSD--CGKTFSQSSHLVQHRRIHTGEKPYACS-ECGKRFSWSSNLMQHQR 149
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191887872 150 IHTGEKPYACPDCGRSFTQSKSLAKHRRSHSGLKPFVCPRCGR-GFSQPKSLARHLRLHPELSGP 213
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSsSVNTPQSNSLHPPLPANSLSK 178
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-168 1.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.20e-06
                          10        20
                  ....*....|....*....|....*.
gi 1191887872 143 NLMQHQRIHTGEKPYACPDCGRSFTQ 168
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 73-95 1.21e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|...
gi 1191887872  73 YICNECGKSFSHWSKLTRHQRTH 95
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-139 1.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.37e-05
                          10        20
                  ....*....|....*....|....*
gi 1191887872 115 HLVQHRRIHTGEKPYACSECGKRFS 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 157-179 3.56e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.56e-04
                          10        20
                  ....*....|....*....|...
gi 1191887872 157 YACPDCGRSFTQSKSLAKHRRSH 179
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 103-123 6.35e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.35e-04
                          10        20
                  ....*....|....*....|.
gi 1191887872 103 CSDCGKTFSQSSHLVQHRRIH 123
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 156-204 9.84e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 9.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1191887872 156 PYACPDCGRSFTQSKSLAKHRRSHSGLKpfVCPRCGRGFSQPKSLARHL 204
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
88-112 1.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|....*
gi 1191887872  88 LTRHQRTHTGERPNACSDCGKTFSQ 112
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 128-175 2.16e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 2.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1191887872 128 PYACSECGKRFSWSSNLMQHQRIHTGEKpyACPDCGRSFTQSKSLAKH 175
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 185-207 2.71e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.71e-03
                          10        20
                  ....*....|....*....|...
gi 1191887872 185 FVCPRCGRGFSQPKSLARHLRLH 207
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
73-95 3.72e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 3.72e-03
                           10        20
                   ....*....|....*....|...
gi 1191887872   73 YICNECGKSFSHWSKLTRHQRTH 95
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 129-151 8.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|...
gi 1191887872 129 YACSECGKRFSWSSNLMQHQRIH 151
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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