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Conserved domains on  [gi|1190969609|ref|XP_020888225|]
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uncharacterized protein C18orf8 isoform X2 [Arabidopsis lyrata subsp. lyrata]

Protein Classification

ANAPC4_WD40 and Mic1 domain-containing protein( domain architecture ID 11677259)

ANAPC4_WD40 and Mic1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mic1 super family cl06189
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 516-663 3.32e-49

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


The actual alignment was detected with superfamily member pfam07035:

Pssm-ID: 429257  Cd Length: 157  Bit Score: 169.34  E-value: 3.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609 516 YLVAIITEFLRSISAEKLKVDLNIYVMTIRLLAYSKRFAELSLFTTNKIIEPSKEVAFQLLESGrqNQNIRVRKLGLDML 595
Cdd:pfam07035   4 YLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLE--NVYPPAFQLALDML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190969609 596 RQLSLHHDYISCLVQDGYYLEALRYAQKHK-VTTVRSSLFLEAAFASNDMQHLAAILRVLSEL------IPGFKE 663
Cdd:pfam07035  82 KRLSAHEEIIEVLLSKGQVLSALRFARSAGgVDSVSARKFLEAAQATNDDMLFYSVYKFFEERnlrlrgSPSFLK 156
ANAPC4_WD40 super family cl14918
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 37-124 7.77e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


The actual alignment was detected with superfamily member pfam12894:

Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609  37 DANRLLICTTSSQVFsWETSPFNPDvppsvdsineGPILSIRFSLDKKAIAVQRSDCEVQLFNRETKKILnHKCKAGSES 116
Cdd:pfam12894  15 EDGELLLHRLNWQRV-WTLSPDKED----------LEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDL 82


                  ....*...
gi 1190969609 117 ILGFFWSD 124
Cdd:pfam12894  83 ITCLGWGE 90
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 516-663 3.32e-49

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 169.34  E-value: 3.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609 516 YLVAIITEFLRSISAEKLKVDLNIYVMTIRLLAYSKRFAELSLFTTNKIIEPSKEVAFQLLESGrqNQNIRVRKLGLDML 595
Cdd:pfam07035   4 YLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLE--NVYPPAFQLALDML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190969609 596 RQLSLHHDYISCLVQDGYYLEALRYAQKHK-VTTVRSSLFLEAAFASNDMQHLAAILRVLSEL------IPGFKE 663
Cdd:pfam07035  82 KRLSAHEEIIEVLLSKGQVLSALRFARSAGgVDSVSARKFLEAAQATNDDMLFYSVYKFFEERnlrlrgSPSFLK 156
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 37-124 7.77e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609  37 DANRLLICTTSSQVFsWETSPFNPDvppsvdsineGPILSIRFSLDKKAIAVQRSDCEVQLFNRETKKILnHKCKAGSES 116
Cdd:pfam12894  15 EDGELLLHRLNWQRV-WTLSPDKED----------LEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDL 82


                  ....*...
gi 1190969609 117 ILGFFWSD 124
Cdd:pfam12894  83 ITCLGWGE 90
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 516-663 3.32e-49

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 169.34  E-value: 3.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609 516 YLVAIITEFLRSISAEKLKVDLNIYVMTIRLLAYSKRFAELSLFTTNKIIEPSKEVAFQLLESGrqNQNIRVRKLGLDML 595
Cdd:pfam07035   4 YLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLE--NVYPPAFQLALDML 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190969609 596 RQLSLHHDYISCLVQDGYYLEALRYAQKHK-VTTVRSSLFLEAAFASNDMQHLAAILRVLSEL------IPGFKE 663
Cdd:pfam07035  82 KRLSAHEEIIEVLLSKGQVLSALRFARSAGgVDSVSARKFLEAAQATNDDMLFYSVYKFFEERnlrlrgSPSFLK 156
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 37-124 7.77e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190969609  37 DANRLLICTTSSQVFsWETSPFNPDvppsvdsineGPILSIRFSLDKKAIAVQRSDCEVQLFNRETKKILnHKCKAGSES 116
Cdd:pfam12894  15 EDGELLLHRLNWQRV-WTLSPDKED----------LEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDL 82


                  ....*...
gi 1190969609 117 ILGFFWSD 124
Cdd:pfam12894  83 ITCLGWGE 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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