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Conserved domains on  [gi|1169027793|ref|XP_020465926|]
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pre-mRNA-splicing factor SYF1 [Monopterus albus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 254-579 4.30e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 254 WCSLADYYIRSGHFEKARDVYEEAIltvvtvrdftQVFDSYAqfeesmiaakmETTAEMGQdvdddidLELRLSRFEQLI 333
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEAL----------ELDPETV-----------EAHLALGN-------LYRRRGEYDRAI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 334 ArrpLLLNsvLLRQNPHNVHEWHKRVKLY--EGNPRQIINTYTEAVQTvDPMKATgkphcLWVSFAKFYEENEQLDDART 411
Cdd:COG2956    63 R---IHQK--LLERDPDRAEALLELAQDYlkAGLLDRAEELLEKLLEL-DPDDAE-----ALRLLAEIYEQEGDWEKAIE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 412 IFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIpskkaeyfdasEPvqnrvyKSLKVWSMLADLEES 491
Cdd:COG2956   132 VLERLLKLG----PENAHAYCELAELYLEQGDYDEAIEALEKALKL-----------DP------DCARALLLLAELYLE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 492 LGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFRWPNVYDiwntYLTKFIDRYGGkkLERA 571
Cdd:COG2956   191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL----ALADLLERKEG--LEAA 264


                  ....*...
gi 1169027793 572 RDLFEQAL 579
Cdd:COG2956   265 LALLERQL 272
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 51-183 1.46e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793  51 IYERALKELPGSYKLWYNY---LRERRKqikgkciteptYEEVNNCHERALVFMHKMPRIWLDYCQFLVSQCKITRSRRT 127
Cdd:COG3914   100 LYRRALALNPDNAEALFNLgnlLLALGR-----------LEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAA 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1169027793 128 FDRALRALPvtQHPRVWPLYLRFVRNLPLPETAIRVYRRYLKLSPENAEEYIDYLR 183
Cdd:COG3914   169 LRRALELDP--DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 254-579 4.30e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 254 WCSLADYYIRSGHFEKARDVYEEAIltvvtvrdftQVFDSYAqfeesmiaakmETTAEMGQdvdddidLELRLSRFEQLI 333
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEAL----------ELDPETV-----------EAHLALGN-------LYRRRGEYDRAI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 334 ArrpLLLNsvLLRQNPHNVHEWHKRVKLY--EGNPRQIINTYTEAVQTvDPMKATgkphcLWVSFAKFYEENEQLDDART 411
Cdd:COG2956    63 R---IHQK--LLERDPDRAEALLELAQDYlkAGLLDRAEELLEKLLEL-DPDDAE-----ALRLLAEIYEQEGDWEKAIE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 412 IFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIpskkaeyfdasEPvqnrvyKSLKVWSMLADLEES 491
Cdd:COG2956   132 VLERLLKLG----PENAHAYCELAELYLEQGDYDEAIEALEKALKL-----------DP------DCARALLLLAELYLE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 492 LGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFRWPNVYDiwntYLTKFIDRYGGkkLERA 571
Cdd:COG2956   191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL----ALADLLERKEG--LEAA 264


                  ....*...
gi 1169027793 572 RDLFEQAL 579
Cdd:COG2956   265 LALLERQL 272
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 51-183 1.46e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793  51 IYERALKELPGSYKLWYNY---LRERRKqikgkciteptYEEVNNCHERALVFMHKMPRIWLDYCQFLVSQCKITRSRRT 127
Cdd:COG3914   100 LYRRALALNPDNAEALFNLgnlLLALGR-----------LEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAA 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1169027793 128 FDRALRALPvtQHPRVWPLYLRFVRNLPLPETAIRVYRRYLKLSPENAEEYIDYLR 183
Cdd:COG3914   169 LRRALELDP--DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
TPR_12 pfam13424
Tetratricopeptide repeat;
391-457 9.44e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 9.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169027793 391 CLWVSFAKFYEENEQLDDARTIFEKA----TKVNYKQVDDLAAVWCEYGEMELRHENYEQALRILRKATAI 457
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKAleiaRRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 396-579 1.26e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 396 FAKFYEENEQLDDARTIFEKATKVNykqvDDLAAVWCEY--------GEMELRHENYEQALRIlrKATAIPSK------K 461
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDELPGKTLLD----DEGAAELLALrglaylglGQLELAQKSYEQALAI--DPRSLYAKlglaqlA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 462 AEYFDASEpVQNRVYKSL-------KVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFK 534
Cdd:TIGR02917 170 LAENRFDE-ARALIDEVLtadpgnvDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK 248

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1169027793 535 AYERGIALFRwpnvydiwNTYLTKFID---RYGGKKLERARDLFEQAL 579
Cdd:TIGR02917 249 HADALLKKAP--------NSPLAHYLKalvDFQKKNYEDARETLQDAL 288
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 254-579 4.30e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 254 WCSLADYYIRSGHFEKARDVYEEAIltvvtvrdftQVFDSYAqfeesmiaakmETTAEMGQdvdddidLELRLSRFEQLI 333
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEAL----------ELDPETV-----------EAHLALGN-------LYRRRGEYDRAI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 334 ArrpLLLNsvLLRQNPHNVHEWHKRVKLY--EGNPRQIINTYTEAVQTvDPMKATgkphcLWVSFAKFYEENEQLDDART 411
Cdd:COG2956    63 R---IHQK--LLERDPDRAEALLELAQDYlkAGLLDRAEELLEKLLEL-DPDDAE-----ALRLLAEIYEQEGDWEKAIE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 412 IFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIpskkaeyfdasEPvqnrvyKSLKVWSMLADLEES 491
Cdd:COG2956   132 VLERLLKLG----PENAHAYCELAELYLEQGDYDEAIEALEKALKL-----------DP------DCARALLLLAELYLE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 492 LGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFRWPNVYDiwntYLTKFIDRYGGkkLERA 571
Cdd:COG2956   191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL----ALADLLERKEG--LEAA 264


                  ....*...
gi 1169027793 572 RDLFEQAL 579
Cdd:COG2956   265 LALLERQL 272
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
393-638 2.76e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 393 WVSFAKFYEENEQLDDARTIFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIPSKKAEyfdasepvq 472
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELD----PDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAE--------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 473 nrvykslkVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFrwPNVYDIW 552
Cdd:COG0457    78 --------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD--PDDADAL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 553 NtylTKFIDRYGGKKLERARDLFEQALDGCPAKFAKTIYLLYAKLEEEYGLARHAMAVYERATRAVETEERHQMFNIYIK 632
Cdd:COG0457   148 Y---NLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLL 224


                  ....*.
gi 1169027793 633 RAAEIY 638
Cdd:COG0457   225 LALALL 230
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 443-656 7.53e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 7.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 443 NYEQALRILRKATAI-PSkkaeyfdasepvqnrvykSLKVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAM 521
Cdd:COG3914    93 RYEEALALYRRALALnPD------------------NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 522 FLEEHNYFEESFKAYERGIALFrwPNVYDIWNTYLTKFIDRyggKKLERARDLFEQALDGCPAKFAKTIYLLYAKLEEEY 601
Cdd:COG3914   155 ALRRLGRLEEAIAALRRALELD--PDNAEALNNLGNALQDL---GRLEEAIAAYRRALELDPDNADAHSNLLFALRQACD 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1169027793 602 GLARHAMAVYERATRAVETEERHQMFN-------IYIKRAAEIYGVTYTRAIYQKAIEVLPD 656
Cdd:COG3914   230 WEVYDRFEELLAALARGPSELSPFALLylpdddpAELLALARAWAQLVAAAAAPELPPPPNP 291
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 397-542 4.63e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 397 AKFYEENEQLDDARTIFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIPSKKAEYfdasepvqnrvy 476
Cdd:COG4783    11 AQALLLAGDYDEAEALLEKALELD----PDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA------------ 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169027793 477 kslkvWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIAL 542
Cdd:COG4783    75 -----RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
345-614 8.65e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 8.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 345 LRQNPHNVHEWHKRVKLYE--GNPRQIINTYTEAVQtVDPMKATgkphcLWVSFAKFYEENEQLDDARTIFEKATKVNyk 422
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRrlGRYEEAIEDYEKALE-LDPDDAE-----ALYNLGLAYLRLGRYEEALADYEQALELD-- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 423 qvDDLAAVWCEYGEMELRHENYEQALRILRKATAIPSKKAEyfdasepvqnrvykslkVWSMLADLEESLGTFQSTKAVY 502
Cdd:COG0457    73 --PDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE-----------------ALYNLGLALLELGRYDEAIEAY 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 503 DRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFRWPNVYDIWNTYLTKFIDRYGGKKLERARDLFEQALDGC 582
Cdd:COG0457   134 ERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAI 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1169027793 583 PAKFAKTIYLLYAKLEEEYGLARHAMAVYERA 614
Cdd:COG0457   214 LTLAALAELLLLALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 51-183 1.46e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793  51 IYERALKELPGSYKLWYNY---LRERRKqikgkciteptYEEVNNCHERALVFMHKMPRIWLDYCQFLVSQCKITRSRRT 127
Cdd:COG3914   100 LYRRALALNPDNAEALFNLgnlLLALGR-----------LEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAA 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1169027793 128 FDRALRALPvtQHPRVWPLYLRFVRNLPLPETAIRVYRRYLKLSPENAEEYIDYLR 183
Cdd:COG3914   169 LRRALELDP--DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 393-508 7.14e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 7.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 393 WVSFAKFYEENEQLDDARTIFEKATKVNykqvDDLAAVWCEYGEMELRHENYEQALRILRKATAIpskkaeyfDASEPvq 472
Cdd:COG4235    20 WLLLGRAYLRLGRYDEALAAYEKALRLD----PDNADALLDLAEALLAAGDTEEAEELLERALAL--------DPDNP-- 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1169027793 473 nrvykslKVWSMLADLEESLGTFQSTKAVYDRIIDL 508
Cdd:COG4235    86 -------EALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 302-539 8.06e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 8.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 302 IAAKMETTAEMGQDVDDDIDLELRLSRFEQLIARRPLLLNSVLLRQNPHNVHEWHKRvklyEGNPRQIINTYTEAVQtVD 381
Cdd:COG3914    34 AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA----LGRYEEALALYRRALA-LN 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 382 PmkatgKPHCLWVSFAKFYEENEQLDDARTIFEKATKVNYkqvdDLAAVWCEYGEMELRHENYEQALRILRKATAIPSKK 461
Cdd:COG3914   109 P-----DNAEALFNLGNLLLALGRLEEALAALRRALALNP----DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 462 AEyfdasepvqnrvykslkVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFL------EEHNYFEESFKA 535
Cdd:COG3914   180 AE-----------------ALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALrqacdwEVYDRFEELLAA 242


                  ....
gi 1169027793 536 YERG 539
Cdd:COG3914   243 LARG 246
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 427-684 1.44e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 427 LAAVWCEYGEMELRHENYEQALRILRKATAIPSKKAEY-------------FDASEpvqnRVYKSL--------KVWSML 485
Cdd:COG2956     7 AALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAhlalgnlyrrrgeYDRAI----RIHQKLlerdpdraEALLEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 486 ADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFrwPNVYDIWNTYLTKFIDRygg 565
Cdd:COG2956    83 AQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG--PENAHAYCELAELYLEQ--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 566 KKLERARDLFEQALDGCPAKFAktIYLLYAKLEEEYGLARHAMAVYERAtravetEERHQMFNIYIKRAAEIYGVT--YT 643
Cdd:COG2956   158 GDYDEAIEALEKALKLDPDCAR--ALLLLAELYLEQGDYEEAIAALERA------LEQDPDYLPALPRLAELYEKLgdPE 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1169027793 644 RAI--YQKAIEVLPDEHARDMcqrFADMECKLGEIDRARAIYS 684
Cdd:COG2956   230 EALelLRKALELDPSDDLLLA---LADLLERKEGLEAALALLE 269
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 158-416 4.24e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 158 ETAIRVYRRYLKLSPENAEEYI----DYLRSvGRLDEAALRLAAVVndegfvsKEGKSNYQLWHELCDL--ISQNPDKvt 231
Cdd:COG2956    59 DRAIRIHQKLLERDPDRAEALLelaqDYLKA-GLLDRAEELLEKLL-------ELDPDDAEALRLLAEIyeQEGDWEK-- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 232 slnvgAI-IRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIltvvtvrdftqvfdsyaQFEESMIAAKMETta 310
Cdd:COG2956   129 -----AIeVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL-----------------KLDPDCARALLLL-- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 311 emgqdvdddIDLELRLSRFEQLIArrplLLNSVlLRQNPHNVHEWHKRVKLYE--GNPRQIINTYTEAVQTvDPMKAtgk 388
Cdd:COG2956   185 ---------AELYLEQGDYEEAIA----ALERA-LEQDPDYLPALPRLAELYEklGDPEEALELLRKALEL-DPSDD--- 246

                         250       260
                  ....*....|....*....|....*...
gi 1169027793 389 phcLWVSFAKFYEENEQLDDARTIFEKA 416
Cdd:COG2956   247 ---LLLALADLLERKEGLEAALALLERQ 271
TPR_12 pfam13424
Tetratricopeptide repeat;
391-457 9.44e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 9.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169027793 391 CLWVSFAKFYEENEQLDDARTIFEKA----TKVNYKQVDDLAAVWCEYGEMELRHENYEQALRILRKATAI 457
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKAleiaRRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 396-579 1.26e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 396 FAKFYEENEQLDDARTIFEKATKVNykqvDDLAAVWCEY--------GEMELRHENYEQALRIlrKATAIPSK------K 461
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDELPGKTLLD----DEGAAELLALrglaylglGQLELAQKSYEQALAI--DPRSLYAKlglaqlA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 462 AEYFDASEpVQNRVYKSL-------KVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFK 534
Cdd:TIGR02917 170 LAENRFDE-ARALIDEVLtadpgnvDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK 248

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1169027793 535 AYERGIALFRwpnvydiwNTYLTKFID---RYGGKKLERARDLFEQAL 579
Cdd:TIGR02917 249 HADALLKKAP--------NSPLAHYLKalvDFQKKNYEDARETLQDAL 288
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 51-174 1.29e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793  51 IYERALKELPGSYKLWYN--YLRERRKQikgkciteptyeevnncHERALVFMHKM-------PRIWLDYCQFLVSQCKI 121
Cdd:COG4783    26 LLEKALELDPDNPEAFALlgEILLQLGD-----------------LDEAIVLLHEAleldpdePEARLNLGLALLKAGDY 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169027793 122 TRSRRTFDRALRALPvtQHPRVWPLYLRFVRNLPLPETAIRVYRRYLKLSPEN 174
Cdd:COG4783    89 DEALALLEKALKLDP--EHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
RNA14 COG5107
Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and ...
 108-627 2.07e-03

Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification];


Pssm-ID: 227438 [Multi-domain]  Cd Length: 660  Bit Score: 41.54  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 108 WLDYCQFLVSQCKITRSRRTFDRALRALPVtqHPRVWPLYLRFVRNLPLPETAIRVYRRYLK--LSPENAEEYIDYLRSV 185
Cdd:COG5107    45 YFQLIQYLETQESMDAEREMYEQLSSPFPI--MEHAWRLYMSGELARKDFRSVESLFGRCLKksLNLDLWMLYLEYIRRV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 186 GRLDEAALRLAAVvndegfvskegksnyqlwhelcdlisqnpdKVTSLNVGAIIrggltrFTDQLGKLWCSLADYyIRSG 265
Cdd:COG5107   123 NNLITGQKRFKIY------------------------------EAYEFVLGCAI------FEPQSENYWDEYGLF-LEYI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 266 ----------HFEKARDVYEEAILTvvTVRDFTQVFDSYAQFEESM--IAAKM---ETTAEmgqdvdddidLELRLSRFE 330
Cdd:COG5107   166 eelgkweeqqRIDKIRNGYMRALQT--PMGNLEKLWKDYENFELELnkITARKfvgETSPI----------YMSARQRYQ 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 331 QLiarrpLLLNSVLLRQNPHNVHEWHKRVKLYEGNPRQIINTYTEavqtvDPMKATGKPHCLWVSFAK-------FYEEN 403
Cdd:COG5107   234 EI-----QNLTRGLSVKNPINLRTANKAARTSDSNWLNWIKWEME-----NGLKLGGRPHEQRIHYIHnqildyfYYAEE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 404 EQLDDARTIFEKATKVNYKQVDDLAAVWC--------EYGEMELRHEN----YEQALR-ILRKATAIPSKKAEYFDAS-- 468
Cdd:COG5107   304 VWFDYSEYLIGISDKQKALKTVERGIEMSpsltmflsEYYELVNDEEAvygcFDKCTQdLKRKYSMGESESASKVDNNfe 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 469 ---EPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVInYAMFLEEHNY--FEESFKAYERGIALF 543
Cdd:COG5107   384 yskELLLKRINKLTFVFCVHLNYVLRKRGLEAARKLFIKLRKEGIVGHHVYI-YCAFIEYYATgdRATAYNIFELGLLKF 462

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 544 rwPNVYDIWNTYLTkFIDRYGgkKLERARDLFEQALDGCPAKFAKTIYLLYAKLEEEYGLARHAMAVYERATRAVETEER 623
Cdd:COG5107   463 --PDSTLYKEKYLL-FLIRIN--DEENARALFETSVERLEKTQLKRIYDKMIEYESMVGSLNNVYSLEERFRELVPQENL 537


                  ....
gi 1169027793 624 HQMF 627
Cdd:COG5107   538 IEVF 541
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 482-584 2.62e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 482 WSMLADLEESLGTFQSTKAVYDRIIDLRIATPQIVINYAMFLEEHNYFEESFKAYERgiALFRWPNVYDIWNTYltkFID 561
Cdd:COG4235    20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLER--ALALDPDNPEALYLL---GLA 94

                          90       100
                  ....*....|....*....|...
gi 1169027793 562 RYGGKKLERARDLFEQALDGCPA 584
Cdd:COG4235    95 AFQQGDYAEAIAAWQKLLALLPA 117
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 344-454 4.33e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 344 LLRQNPHNVHEWHKRVKLY--EGNPRQIINTYTEAVQtVDPMKATgkphcLWVSFAKFYEENEQLDDARTIFEKATKVNy 421
Cdd:COG4783    30 ALELDPDNPEAFALLGEILlqLGDLDEAIVLLHEALE-LDPDEPE-----ARLNLGLALLKAGDYDEALALLEKALKLD- 102

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1169027793 422 kqvDDLAAVWCEYGEMELRHENYEQALRILRKA 454
Cdd:COG4783   103 ---PEHPEAYLRLARAYRALGRPDEAIAALEKA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 428-583 5.34e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793 428 AAVWCEYGEMELRHENYEQALRILRKATAIpskkaeyfdasEPvqnrvyKSLKVWSMLADLEESLGTFQSTKAVYDRIID 507
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALEL-----------DP------DNPEAFALLGEILLQLGDLDEAIVLLHEALE 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169027793 508 LRIATPQIVINYAMFLEEHNYFEESFKAYERGIALFrwPNVYDIWNtYLTKFIDRYGgkKLERARDLFEQALDGCP 583
Cdd:COG4783    67 LDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD--PEHPEAYL-RLARAYRALG--RPDEAIAALEKALELDP 137
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 52-179 8.42e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169027793  52 YERALKELPGSYKLWYN----YLRERRkqikgkciteptYEEVNNCHERALVFMHKMPRIWLDYCQFLVSQCKITRSRRT 127
Cdd:COG4235     6 LRQALAANPNDAEGWLLlgraYLRLGR------------YDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1169027793 128 FDRALRALPvtQHPRVWPLYLRFVRNLPLPETAIRVYRRYLKLSPENAEEYI 179
Cdd:COG4235    74 LERALALDP--DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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