|
Name |
Accession |
Description |
Interval |
E-value |
| recomb_DMC1 |
TIGR02238 |
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ... |
26-261 |
6.09e-151 |
|
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.
Pssm-ID: 131292 [Multi-domain] Cd Length: 313 Bit Score: 423.81 E-value: 6.09e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 26 IDTLQKHGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGKMLTNGFLTAFEYSAKRKQVFRITT 105
Cdd:TIGR02238 1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 106 GSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVDHDA 185
Cdd:TIGR02238 81 GSQALDGILGGGIESMSITEVFGEFRCGKTQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRAIAERFGVDPDA 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137495927 186 VLDNVLYARAYTSEHQMELLDFVAAKFHEEggVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISED 261
Cdd:TIGR02238 161 VLDNILYARAYTSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEE 234
|
|
| PTZ00035 |
PTZ00035 |
Rad51 protein; Provisional |
9-260 |
2.71e-140 |
|
Rad51 protein; Provisional
Pssm-ID: 185407 [Multi-domain] Cd Length: 337 Bit Score: 397.83 E-value: 2.71e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 9 VEDEAGYQDDEESFFQDIDTLQKHGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGKMLTNGFL 88
Cdd:PTZ00035 6 NEQQEEEEEEEAEGFQEIEKLQSAGINAADIKKLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGFI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 89 TAFEYSAKRKQVFRITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFR 168
Cdd:PTZ00035 86 SATEYLEARKNIIRITTGSTQLDKLLGGGIETGSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 169 PDRLKDIAERFNVDHDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGRGELAERQQKL 248
Cdd:PTZ00035 166 PERIVQIAERFGLDPEDVLDNIAYARAYNHEHQMQLLSQAAAKMAEER--FALLIVDSATALFRVDYSGRGELAERQQHL 243
|
250
....*....|..
gi 1137495927 249 AQMLSRLQKISE 260
Cdd:PTZ00035 244 GKFLRALQKLAD 255
|
|
| PLN03187 |
PLN03187 |
meiotic recombination protein DMC1 homolog; Provisional |
2-261 |
9.58e-125 |
|
meiotic recombination protein DMC1 homolog; Provisional
Pssm-ID: 215620 [Multi-domain] Cd Length: 344 Bit Score: 358.71 E-value: 9.58e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 2 KAAEDQVVEDEAGyqDDEESFFQDIDTLQKHGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGK 81
Cdd:PLN03187 9 EGAQLQLVEAEEV--DEEEDLFESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 82 MLTNGFLTAFEYSAKRKQVFRITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFI 161
Cdd:PLN03187 87 LLNQGFITGSDALLKRKSVVRITTGSQALDELLGGGIETRCITEAFGEFRSGKTQLAHTLCVTTQLPTEMGGGNGKVAYI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 162 DTENTFRPDRLKDIAERFNVDHDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGRGEL 241
Cdd:PLN03187 167 DTEGTFRPDRIVPIAERFGMDADAVLDNIIYARAYTYEHQYNLLLGLAAKMAEEP--FRLLIVDSVIALFRVDFTGRGEL 244
|
250 260
....*....|....*....|
gi 1137495927 242 AERQQKLAQMLSRLQKISED 261
Cdd:PLN03187 245 AERQQKLAQMLSRLTKIAEE 264
|
|
| DMC1 |
cd19514 |
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ... |
103-261 |
2.85e-120 |
|
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.
Pssm-ID: 410922 [Multi-domain] Cd Length: 236 Bit Score: 343.19 E-value: 2.85e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVD 182
Cdd:cd19514 1 ISTGSTELDKLLGGGIESMSITEVFGEFRTGKTQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRPIAERFGVD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1137495927 183 HDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEgGVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISED 261
Cdd:cd19514 81 HDAVLDNILYARAYTSEHQMELLDYVAAKFHEE-AVFRLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEE 158
|
|
| PLN03186 |
PLN03186 |
DNA repair protein RAD51 homolog; Provisional |
1-261 |
2.18e-109 |
|
DNA repair protein RAD51 homolog; Provisional
Pssm-ID: 178728 [Multi-domain] Cd Length: 342 Bit Score: 319.76 E-value: 2.18e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 1 MKAAEDQVVEDEAGYQDDEESFFQD--IDTLQKHGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEA 78
Cdd:PLN03186 1 MAQAVAAAAAQAMQEEEEEEAAHGPfpIEQLQASGIAALDIKKLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 79 AGKMLTNGFLTAFEYSAKRKQVFRITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKV 158
Cdd:PLN03186 81 ASKLVPLGFTTASQLHAQRQEIIQITTGSRELDKILEGGIETGSITEIYGEFRTGKTQLCHTLCVTCQLPLDQGGGEGKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 159 IFIDTENTFRPDRLKDIAERFNVDHDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGR 238
Cdd:PLN03186 161 MYIDTEGTFRPQRLIQIAERFGLNGADVLENVAYARAYNTDHQSELLLEAASMMAETR--FALMIVDSATALYRTEFSGR 238
|
250 260
....*....|....*....|...
gi 1137495927 239 GELAERQQKLAQMLSRLQKISED 261
Cdd:PLN03186 239 GELSARQMHLGKFLRSLQRLADE 261
|
|
| recomb_RAD51 |
TIGR02239 |
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ... |
26-261 |
6.11e-104 |
|
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).
Pssm-ID: 274048 [Multi-domain] Cd Length: 316 Bit Score: 305.11 E-value: 6.11e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 26 IDTLQKHGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGKMLTNGFLTAFEYSAKRKQVFRITT 105
Cdd:TIGR02239 1 IEKLEGNGITAADIKKLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRQEVIQLTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 106 GSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVDHDA 185
Cdd:TIGR02239 81 GSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAERYGLNPED 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137495927 186 VLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISED 261
Cdd:TIGR02239 161 VLDNVAYARAYNTDHQLQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADE 234
|
|
| Rad51 |
pfam08423 |
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ... |
86-260 |
1.25e-99 |
|
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.
Pssm-ID: 462471 [Multi-domain] Cd Length: 255 Bit Score: 291.90 E-value: 1.25e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 86 GFLTAFEYSAKRKQVFRITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTEN 165
Cdd:pfam08423 2 GFTTATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 166 TFRPDRLKDIAERFNVDHDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGRGELAERQ 245
Cdd:pfam08423 82 TFRPERLVAIAERYGLDPEDVLDNVAYARAYNSEHQMQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELAERQ 159
|
170
....*....|....*
gi 1137495927 246 QKLAQMLSRLQKISE 260
Cdd:pfam08423 160 QHLAKFLRTLQRLAD 174
|
|
| Rad51_DMC1_archRadA |
cd01123 |
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ... |
103-260 |
5.15e-97 |
|
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Pssm-ID: 410868 [Multi-domain] Cd Length: 234 Bit Score: 284.42 E-value: 5.15e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVD 182
Cdd:cd01123 1 ITTGSKELDKLLGGGIETGSITEMFGEFRTGKTQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIAQRFGLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137495927 183 HDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEggVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISE 260
Cdd:cd01123 81 PDDVLDNVAYARAFNSDHQTQLLDQAAAMMVES--RFKLLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLAD 156
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
33-261 |
2.63e-86 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 260.19 E-value: 2.63e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 33 GINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGKMLT-NGFLTAFEYSAKRKQVFRITTGSLEFD 111
Cdd:PRK04301 13 GVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAAKIIEAAREAADiGGFETALEVLERRKNVGKITTGSKELD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 112 KLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVDHDAVLDNVL 191
Cdd:PRK04301 93 ELLGGGIETQSITEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEALGLDPDEVLDNIH 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 192 YARAYTSEHQMELLDfVAAKFHEEGGVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISED 261
Cdd:PRK04301 173 VARAYNSDHQMLLAE-KAEELIKEGENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADL 241
|
|
| Rad51 |
cd19513 |
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ... |
103-260 |
7.34e-81 |
|
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.
Pssm-ID: 410921 [Multi-domain] Cd Length: 235 Bit Score: 243.38 E-value: 7.34e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVD 182
Cdd:cd19513 1 ITTGSKELDKLLGGGIETGSITELFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAERYGLN 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137495927 183 HDAVLDNVLYARAYTSEHQMELLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISE 260
Cdd:cd19513 81 GEDVLDNVAYARAYNTDHQMQLLIQASAMMAESR--YALLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLAD 156
|
|
| recomb_radA |
TIGR02236 |
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ... |
33-260 |
5.57e-80 |
|
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 131290 [Multi-domain] Cd Length: 310 Bit Score: 243.88 E-value: 5.57e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 33 GINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGKML-TNGFLTAFEYSAKRKQVFRITTGSLEFD 111
Cdd:TIGR02236 6 GVGPATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAAdLGGFETADDVLERRKTIGKITTGSKELD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 112 KLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVDHDAVLDNVL 191
Cdd:TIGR02236 86 ELLGGGIETQAITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEARGLDPDEVLKNIY 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1137495927 192 YARAYTSEHQMELLDFVAAKFHEEGGVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISE 260
Cdd:TIGR02236 166 VARAYNSNHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLAD 234
|
|
| archRadA |
cd19515 |
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ... |
103-260 |
2.64e-69 |
|
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)
Pssm-ID: 410923 [Multi-domain] Cd Length: 233 Bit Score: 213.76 E-value: 2.64e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERFNVD 182
Cdd:cd19515 1 ISTGSKELDKLLGGGIETQAITEVFGEFGSGKTQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKALGLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137495927 183 HDAVLDNVLYARAYTSEHQMELLDfVAAKFHEEGGVFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISE 260
Cdd:cd19515 81 PDEVLDNIYVARAYNSNHQMLLVE-KAEDLIKEGNNIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLAD 157
|
|
| RecA-like |
cd01393 |
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
123-261 |
1.06e-31 |
|
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Pssm-ID: 410881 [Multi-domain] Cd Length: 185 Bit Score: 115.53 E-value: 1.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 123 ITEAFGEFRTGKTQLSHTLCVTAQLpgedgyTGGKVIFIDTENTFRPDRLKDIAER---FNVDHDAVLDNVLYARAYTSE 199
Cdd:cd01393 3 ITEIYGPPGSGKTQLALQLAANALL------LGGGVVWIDTEGAFPPSRLVQILEAspsSELELAEALSRLLYFRPPDTL 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137495927 200 HQMELLDfVAAKFHEEGGVFKLLVIDSIMALFRVDF----SGRGELAERQQKLAQMLSRLQKISED 261
Cdd:cd01393 77 AHLLALD-SLPESLFPPPNTSLVVVDSVSALFRKAFprggDGDSSSSLRARLLSQLARALQKLAAQ 141
|
|
| XRCC3 |
cd19491 |
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ... |
110-260 |
5.75e-31 |
|
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410899 [Multi-domain] Cd Length: 250 Bit Score: 115.47 E-value: 5.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 110 FDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAERF-----NVDHD 184
Cdd:cd19491 1 LDELLGGGIPVGGITEIAGESGAGKTQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQLASSLpkryhLEKAK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1137495927 185 AVLDNVLYARAYTSEHQMELLDFVAAKFHEEGGVfKLLVIDSIMALFRVDF-SGRGELAERQQKLAQMLSRLQKISE 260
Cdd:cd19491 81 NFLDNIFVEHVADLETLEHCLNYQLPALLERGPI-RLVVIDSIAALFRSEFdTSRSDLVERAKYLRRLADHLKRLAD 156
|
|
| RecA |
COG0468 |
RecA/RadA recombinase [Replication, recombination and repair]; |
95-232 |
3.75e-24 |
|
RecA/RadA recombinase [Replication, recombination and repair];
Pssm-ID: 440236 [Multi-domain] Cd Length: 351 Bit Score: 99.47 E-value: 3.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 95 AKRKQVFRITTGSLEFDKLLG-GGMESMAITEAFGEFRTGKTQLSHTLCVTAQLpgedgyTGGKVIFIDTENTFRPDRlk 173
Cdd:COG0468 36 KARQDVEVISTGSLALDIALGvGGLPRGRIVEIYGPESSGKTTLALHAIAEAQK------AGGIAAFIDAEHALDPEY-- 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1137495927 174 diAERFNVDhdavLDNVLYARAYTSEHQMELLDFVAakfhEEGGVfKLLVIDSIMALFR 232
Cdd:COG0468 108 --AKKLGVD----IDNLLVSQPDTGEQALEIAETLV----RSGAV-DLIVVDSVAALVP 155
|
|
| radB |
PRK09361 |
DNA repair and recombination protein RadB; Provisional |
102-259 |
5.54e-23 |
|
DNA repair and recombination protein RadB; Provisional
Pssm-ID: 236482 [Multi-domain] Cd Length: 225 Bit Score: 93.77 E-value: 5.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 102 RITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLpgedgyTGGKVIFIDTENtFRPDRLKDIAERfnv 181
Cdd:PRK09361 4 RLPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNICLQLAVEAAK------NGKKVIYIDTEG-LSPERFKQIAGE--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 182 DHDAVLDNVLYARAYTSEHQ----MELLDFVAAKfheeggvFKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQK 257
Cdd:PRK09361 74 DFEELLSNIIIFEPSSFEEQseaiRKAEKLAKEN-------VGLIVLDSATSLYRLELEDEEDNSKLNRELGRQLTHLLK 146
|
..
gi 1137495927 258 IS 259
Cdd:PRK09361 147 LA 148
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
111-261 |
4.59e-21 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 88.53 E-value: 4.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 111 DKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFRPDRLKDIAER-----------F 179
Cdd:cd19493 1 DTALAGGLPLGAITEITGASGSGKTQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIAEArfpeafsgfmeE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 180 NVDHDAVLDNVLYARAYTSEhqmELLDFVAAKFHE--EGGVfKLLVIDSIMALFRVDFSG-RGELAERQQKLAQMLSRLQ 256
Cdd:cd19493 81 NERAEEMLKRVAVVRVTTLA---QLLERLPNLEEHilSSGV-RLVVIDSIAALVRREFGGsDGEVTERHNALAREASSLK 156
|
....*
gi 1137495927 257 KISED 261
Cdd:cd19493 157 RLAEE 161
|
|
| archRadB |
cd01394 |
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ... |
103-257 |
9.54e-20 |
|
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.
Pssm-ID: 410882 [Multi-domain] Cd Length: 216 Bit Score: 85.06 E-value: 9.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAqlpgedGYTGGKVIFIDTENtFRPDRLKDIAERfnvD 182
Cdd:cd01394 1 LSTGSKSLDSLLGGGVERGTITQIYGPPGSGKTNICLQLAVEA------AKQGKKVVYIDTEG-LSPERFQQIAGE---R 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137495927 183 HDAVLDNVLYARAYTSEHQMELLDfVAAKFHEEGGVfKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQK 257
Cdd:cd01394 71 FESIASNIIVFEPYSFDEQGVAIQ-EAEKLLKSDKV-DLVVVDSATALYRLELGDDSEANRELSRQMSKLLSIAR 143
|
|
| recomb_radB |
TIGR02237 |
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ... |
111-259 |
5.54e-16 |
|
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).
Pssm-ID: 274047 [Multi-domain] Cd Length: 209 Bit Score: 74.37 E-value: 5.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 111 DKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQlpgedgYTGGKVIFIDTENtFRPDRLKDIAERfnvDHDAVLDNV 190
Cdd:TIGR02237 2 DELLGGGVERGTITQIYGPPGSGKTNICMILAVNAA------RQGKKVVYIDTEG-LSPERFKQIAED---RPERALSNF 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1137495927 191 LYARAYTSEHQ----MELLDFVAAKfheeggVFKLLVIDSIMALFRVDFSGRGELAERQqkLAQMLSRLQKIS 259
Cdd:TIGR02237 72 IVFEVFDFDEQgvaiQKTSKFIDRD------SASLVVVDSFTALYRLELSDDRISRNRE--LARQLTLLLSLA 136
|
|
| Rad51C |
cd19492 |
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
123-260 |
7.32e-15 |
|
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Pssm-ID: 410900 [Multi-domain] Cd Length: 172 Bit Score: 70.72 E-value: 7.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 123 ITEAFGEFRTGKTQLSHTLCVTAQLPGEDGYTGGKVIFIDTENTFrpdrlkdiaerfnvdhdavldNVLYARAYTSEHQM 202
Cdd:cd19492 3 ITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF---------------------NIHYFRVHDYVELL 61
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1137495927 203 ELLDFVAAKFHEEGGVfKLLVIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISE 260
Cdd:cd19492 62 ALINSLPKFLEDHPKV-KLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
|
|
| Rad51D |
cd19489 |
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
115-231 |
2.08e-14 |
|
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410897 [Multi-domain] Cd Length: 209 Bit Score: 69.97 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 115 GGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLpgedgYTGGKVIFIDTENTFRPDRLKDIAE-RFNVDH--DAVLDNVL 191
Cdd:cd19489 1 GGGLRTGEITELVGESSSGKTQLCLTAAANVAS-----RSGQNVLYIDTKSSFSARRLAQILKsRAQDAEeiDKALQRIR 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1137495927 192 YARAYTSEHQMELLDFVAAKFHEEGGV----FKLLVIDSIMALF 231
Cdd:cd19489 76 VVRVFDPYELLDLLEELRNTLSQQQENlysrLKLVIIDSLSALI 119
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
102-258 |
2.09e-10 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 59.16 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 102 RITTGSLEFDKLLGGGME---SMAITeafGEFRTGKTQLSHTLCVTAQLPGEdgytggKVIFIDTENtfRPDRLKDIAER 178
Cdd:COG0467 1 RVPTGIPGLDELLGGGLPrgsSTLLS---GPPGTGKTTLALQFLAEGLRRGE------KGLYVSFEE--SPEQLLRRAES 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 179 FNVDHDAVLDN--VLYARAYTSEHQMELLDFVAA--KFHEEGGVfKLLVIDSIMALFRvdfsgrgeLAERQQKLAQMLSR 254
Cdd:COG0467 70 LGLDLEEYIESglLRIIDLSPEELGLDLEELLARlrEAVEEFGA-KRVVIDSLSGLLL--------ALPDPERLREFLHR 140
|
....
gi 1137495927 255 LQKI 258
Cdd:COG0467 141 LLRY 144
|
|
| XRCC2 |
cd19490 |
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
132-257 |
9.59e-10 |
|
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.
Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 57.36 E-value: 9.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 132 TGKTQLSHTLCVTAQLPGEDGYT--GGK---VIFIDTENTFRPDRLKDIAE-RFN------------VDHDAV----LDN 189
Cdd:cd19490 12 SGKTELLYHLAARCILPSSWGGVplGGLeaaVVFIDTDGRFDILRLRSILEaRIRaaiqaanssddeEDVEEIarecLQR 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137495927 190 VLYARAYTSEH---QMELLDFVAAKFHEEGGVfKLLVIDSIMALFRVDFSGRGELAERQQ-------KLAQMLSRLQK 257
Cdd:cd19490 92 LHIFRCHSSLQllaTLLSLENYLLSLSANPEL-GLLLIDSISAFYWQDRFSAELARAAPLlqeaalrAILRELRRLRR 168
|
|
| RecA |
pfam00154 |
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA ... |
96-259 |
7.15e-09 |
|
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyzes an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.
Pssm-ID: 425488 [Multi-domain] Cd Length: 262 Bit Score: 55.10 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 96 KRKQVFRITTGSLEFDKLLG-GGMESMAITEAFGEFRTGKTQLshTLCVTAQLPGEdgytGGKVIFIDTENTFRPdrlkD 174
Cdd:pfam00154 26 KKLDVETISTGSLALDIALGiGGYPKGRIIEIYGPESSGKTTL--ALHAIAEAQKA----GGTAAFIDAEHALDP----V 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 175 IAERFNVDhdavLDNVLYARAYTSEHQMELLDFVAakfheEGGVFKLLVIDSIMALF-RVDFSgrGELAERQQKL-AQML 252
Cdd:pfam00154 96 YAKKLGVD----IDNLLVSQPDTGEQALEIADMLV-----RSGAIDLIVVDSVAALVpKAEIE--GEMGDSHVGLqARLM 164
|
....*...
gi 1137495927 253 SR-LQKIS 259
Cdd:pfam00154 165 SQaLRKLT 172
|
|
| recA |
PRK09519 |
intein-containing recombinase RecA; |
97-237 |
1.11e-07 |
|
intein-containing recombinase RecA;
Pssm-ID: 77219 [Multi-domain] Cd Length: 790 Bit Score: 52.79 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 97 RKQVFRITTGSLEFDKLLG-GGMESMAITEAFGEFRTGKTQLSHTLCVTAQLpgedgyTGGKVIFIDTENTFRPdrlkDI 175
Cdd:PRK09519 35 RQPISVIPTGSIALDVALGiGGLPRGRVIEIYGPESSGKTTVALHAVANAQA------AGGVAAFIDAEHALDP----DY 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1137495927 176 AERFNVDHDAvldnVLYARAYTSEHQMELLDFVAakfheEGGVFKLLVIDSIMALF-RVDFSG 237
Cdd:PRK09519 105 AKKLGVDTDS----LLVSQPDTGEQALEIADMLI-----RSGALDIVVIDSVAALVpRAELEG 158
|
|
| KaiC-like |
cd01124 |
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ... |
103-232 |
3.37e-07 |
|
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410869 [Multi-domain] Cd Length: 222 Bit Score: 49.95 E-value: 3.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 103 ITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLSHTLCVTAQLPGEdgytggKVIFIDTENTfrPDRLKDIAERFNVD 182
Cdd:cd01124 1 VKTGIPGLDELLGGGIPKGSVTLLTGGPGTGKTLFGLQFLYAGAKNGE------PGLFFTFEES--PERLLRNAKSFGWD 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1137495927 183 HDA--VLDNVLYARAYTSEHQMELLDFVAAKFH---EEGGVfKLLVIDSIMALFR 232
Cdd:cd01124 73 FDEmeDEGKLIIVDAPPTEAGRFSLDELLSRILsiiKSFKA-KRVVIDSLSGLRR 126
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
23-81 |
5.53e-05 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 40.16 E-value: 5.53e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1137495927 23 FQDIDTLQkhGINMADLKKLKSVGICTVKGIQMTTRKALCNIKGLSEAKVDKIKEAAGK 81
Cdd:pfam14520 1 FEELLSIS--GIGPKTALALLSAGIGTVEDLAEADVDELAEIPGIGEKTAQRIILELRD 57
|
|
| RadA_SMS_N |
cd01121 |
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ... |
102-237 |
4.08e-03 |
|
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.
Pssm-ID: 410866 [Multi-domain] Cd Length: 268 Bit Score: 37.90 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137495927 102 RITTGSLEFDKLLGGGMESMAITEAFGEFRTGKTQLShtLCVTAQLPGEdgytGGKVIFIDTENTfrPDRLKDIAERFNV 181
Cdd:cd01121 63 RISTGIGELDRVLGGGLVPGSVVLIGGDPGIGKSTLL--LQVAARLAQR----GGKVLYVSGEES--LSQIKLRAERLGL 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1137495927 182 DHDAvldnvLYARAYTSehqmelLDFVAAKFHEEGgvFKLLVIDSIMALFRVDFSG 237
Cdd:cd01121 135 GSDN-----LYLLAETN------LEAILAEIEELK--PSLVVIDSIQTVYSPELTS 177
|
|
| |
