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Conserved domains on  [gi|1529987525|ref|XP_019127416|]
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elongation factor Ts, mitochondrial [Larimichthys crocea]

Protein Classification

translation elongation factor Ts( domain architecture ID 1012257)

translation elongation factor Ts associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP

CATH:  3.30.479.20
Gene Ontology:  GO:0003746|GO:0006414
SCOP:  4001143

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Tsf super family cl33821
Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; ...
38-302 3.27e-53

Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; Translation elongation factor EF-Ts is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0264:

Pssm-ID: 440034 [Multi-domain]  Cd Length: 290  Bit Score: 175.65  E-value: 3.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHEQAQKegwsKANKLEGRKAKEGLIGLFIRDKAAVMVEVNCETDF 117
Cdd:COG0264     6 ALVKELRERTGAGMMDCKKALTEADGDIEKAIEILRKKGLA----KAAKKAGRVAAEGLVAVAVDGKKGAIVEVNCETDF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 118 VARNEKFQQLVKDVAFATLAHHqdknqskagyVKSVlagDELNKLSVaEGASLADHVALTIGRLGENMSVKRAVTVgiPA 197
Cdd:COG0264    82 VAKNEDFQAFANEVAEAALAAK----------PADV---EALLAAPL-DGKTVEEAITELIAKIGENISLRRFARL--EV 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 198 EWCIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLgNMDDLPCG--ESETR-------- 267
Cdd:COG0264   146 GGVVGSYVHNG---------GKIGVLVALEGDADEE---LAKDIAMHIAAMNPKYL-SREDVPAEvvEKEREiateqare 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1529987525 268 ------------------------LLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGE 302
Cdd:COG0264   213 egkpeniiekivegrlnkflkevtLLEQPFVKDPKKTVGQLLKEAGAKVVGFVRFEVGE 271
 
Name Accession Description Interval E-value
Tsf COG0264
Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; ...
38-302 3.27e-53

Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; Translation elongation factor EF-Ts is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440034 [Multi-domain]  Cd Length: 290  Bit Score: 175.65  E-value: 3.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHEQAQKegwsKANKLEGRKAKEGLIGLFIRDKAAVMVEVNCETDF 117
Cdd:COG0264     6 ALVKELRERTGAGMMDCKKALTEADGDIEKAIEILRKKGLA----KAAKKAGRVAAEGLVAVAVDGKKGAIVEVNCETDF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 118 VARNEKFQQLVKDVAFATLAHHqdknqskagyVKSVlagDELNKLSVaEGASLADHVALTIGRLGENMSVKRAVTVgiPA 197
Cdd:COG0264    82 VAKNEDFQAFANEVAEAALAAK----------PADV---EALLAAPL-DGKTVEEAITELIAKIGENISLRRFARL--EV 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 198 EWCIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLgNMDDLPCG--ESETR-------- 267
Cdd:COG0264   146 GGVVGSYVHNG---------GKIGVLVALEGDADEE---LAKDIAMHIAAMNPKYL-SREDVPAEvvEKEREiateqare 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1529987525 268 ------------------------LLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGE 302
Cdd:COG0264   213 egkpeniiekivegrlnkflkevtLLEQPFVKDPKKTVGQLLKEAGAKVVGFVRFEVGE 271
EF_TS pfam00889
Elongation factor TS;
106-302 1.08e-39

Elongation factor TS;


Pssm-ID: 459984  Cd Length: 204  Bit Score: 138.05  E-value: 1.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 106 AVMVEVNCETDFVARNEKFQQLVKDVAFATLAHHqdknqskagyVKSVlagDELNKLSVAEGASLADHVALTIGRLGENM 185
Cdd:pfam00889   1 AVIVEVNSETDFVAKNEDFQEFVNKIAEAALAAK----------PADV---EELLALKLEGGETVEDALTELIAKIGENI 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 186 SVKRAVTVGIPAEwCIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLgNMDDLPCG--E 263
Cdd:pfam00889  68 VLRRFATLEGDGG-VVGSYIHGN---------GRIGVLVALEGDDDEE---LAKDIAMHIAAMNPQYL-SRDDVPAEvlE 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1529987525 264 SETR--------------------------------LLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGE 302
Cdd:pfam00889 134 KEREilkaqakeegkpeniiekivegrlnkflkevcLLEQPFVKDPKKTVEQYLKEAGKKVVSFVRFEVGE 204
tsf TIGR00116
translation elongation factor Ts; Translational elongation factor Ts (EF-Ts) catalyzes the ...
39-308 3.17e-39

translation elongation factor Ts; Translational elongation factor Ts (EF-Ts) catalyzes the exchange of GTP for the GDP of the EF-Tu.GDP complex as part of the cycle of translation elongation. This protein is found in Bacteria, mitochondria, and chloroplasts. [Protein synthesis, Translation factors]


Pssm-ID: 272914 [Multi-domain]  Cd Length: 291  Bit Score: 139.53  E-value: 3.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  39 LLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHEQaqkeGWSKANKLEGRKAKEGLIGLFIRDKAAVMVEVNCETDFV 118
Cdd:TIGR00116   8 LVKELRERTGAGMMDCKKALVEANGDFEKAIKWLREK----GIAKAAKKADRVAAEGVIVLKSDNHKAVIVEVNSETDFV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 119 ARNEKFQQLVKDVAFATLAHHQDKnqskagyVKSVLAGDELNKLSVAEGASLAdhvaltiGRLGENMSVKRAVTVGIPAE 198
Cdd:TIGR00116  84 AKNEGFKEFANKLLDELKANPITT-------LEELQKQELENKEKVEYLASLA-------AKIGENIVLRRVAVLEGQSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 199 WcIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLGNMD----------------DLPCG 262
Cdd:TIGR00116 150 V-IFSYLHAN---------ARIGVLVELKGKADEE---LAKHLAMHVAANKPQFIDQDDvsqewvkkerqiitdqAELSG 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1529987525 263 E-----------------SETRLLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGETVSEEA 308
Cdd:TIGR00116 217 KpkeilekmvegrmkkflAEISLLGQKFVMDPSKTVGQFLKEKNAKVTEFVRFEVGEGIEKKA 279
tsf PRK12332
elongation factor Ts; Reviewed
38-132 8.15e-28

elongation factor Ts; Reviewed


Pssm-ID: 183447 [Multi-domain]  Cd Length: 198  Bit Score: 106.91  E-value: 8.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLheqaQKEGWSKANKLEGRKAKEGLIGLFIR--DKAAVMVEVNCET 115
Cdd:PRK12332    6 KLVKELREKTGAGMMDCKKALEEANGDMEKAIEWL----REKGLAKAAKKAGRVAAEGLVGSYIHtgGRIGVLVELNCET 81
                          90
                  ....*....|....*..
gi 1529987525 116 DFVARNEKFQQLVKDVA 132
Cdd:PRK12332   82 DFVARTEEFKELAKDIA 98
UBA_EF-Ts cd14275
UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria ...
38-74 2.23e-12

UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes; EF-Ts functions as a nucleotide exchange factor in the functional cycle of EF-Tu, another translation elongation factor that facilitates the binding of aminoacylated transfer RNAs (aminoacyl-tRNA) to the ribosomal A site as a ternary complex with guanosine triphosphate during the elongation cycle of protein biosynthesis, and then catalyzes the hydrolysis of GTP and release itself in GDP-bound form. EF-Ts forms complex with EF-Tu and catalyzes the nucleotide exchange reaction promoting the formation of EF-Tu in GTP-bound form from EF-Tu in GDP-bound form. EF-Ts from Thermus thermophiles is shorter than EF-Ts from Escherichia coli, but it has higher thermostability. The mitochondrial translational EF-Ts from chloroplasts and mitochondria display high similarity to the bacterial EF-Ts. The majority of family members contain one ubiquitin-associated (UBA) domain, but some family members from plants harbor two tandem UBA domains.


Pssm-ID: 270461 [Multi-domain]  Cd Length: 37  Bit Score: 60.48  E-value: 2.23e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHE 74
Cdd:cd14275     1 ELIKELREKTGAGIMDCKKALEEANGDLEKAIEWLRK 37
 
Name Accession Description Interval E-value
Tsf COG0264
Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; ...
38-302 3.27e-53

Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]; Translation elongation factor EF-Ts is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440034 [Multi-domain]  Cd Length: 290  Bit Score: 175.65  E-value: 3.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHEQAQKegwsKANKLEGRKAKEGLIGLFIRDKAAVMVEVNCETDF 117
Cdd:COG0264     6 ALVKELRERTGAGMMDCKKALTEADGDIEKAIEILRKKGLA----KAAKKAGRVAAEGLVAVAVDGKKGAIVEVNCETDF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 118 VARNEKFQQLVKDVAFATLAHHqdknqskagyVKSVlagDELNKLSVaEGASLADHVALTIGRLGENMSVKRAVTVgiPA 197
Cdd:COG0264    82 VAKNEDFQAFANEVAEAALAAK----------PADV---EALLAAPL-DGKTVEEAITELIAKIGENISLRRFARL--EV 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 198 EWCIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLgNMDDLPCG--ESETR-------- 267
Cdd:COG0264   146 GGVVGSYVHNG---------GKIGVLVALEGDADEE---LAKDIAMHIAAMNPKYL-SREDVPAEvvEKEREiateqare 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1529987525 268 ------------------------LLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGE 302
Cdd:COG0264   213 egkpeniiekivegrlnkflkevtLLEQPFVKDPKKTVGQLLKEAGAKVVGFVRFEVGE 271
EF_TS pfam00889
Elongation factor TS;
106-302 1.08e-39

Elongation factor TS;


Pssm-ID: 459984  Cd Length: 204  Bit Score: 138.05  E-value: 1.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 106 AVMVEVNCETDFVARNEKFQQLVKDVAFATLAHHqdknqskagyVKSVlagDELNKLSVAEGASLADHVALTIGRLGENM 185
Cdd:pfam00889   1 AVIVEVNSETDFVAKNEDFQEFVNKIAEAALAAK----------PADV---EELLALKLEGGETVEDALTELIAKIGENI 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 186 SVKRAVTVGIPAEwCIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLgNMDDLPCG--E 263
Cdd:pfam00889  68 VLRRFATLEGDGG-VVGSYIHGN---------GRIGVLVALEGDDDEE---LAKDIAMHIAAMNPQYL-SRDDVPAEvlE 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1529987525 264 SETR--------------------------------LLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGE 302
Cdd:pfam00889 134 KEREilkaqakeegkpeniiekivegrlnkflkevcLLEQPFVKDPKKTVEQYLKEAGKKVVSFVRFEVGE 204
tsf TIGR00116
translation elongation factor Ts; Translational elongation factor Ts (EF-Ts) catalyzes the ...
39-308 3.17e-39

translation elongation factor Ts; Translational elongation factor Ts (EF-Ts) catalyzes the exchange of GTP for the GDP of the EF-Tu.GDP complex as part of the cycle of translation elongation. This protein is found in Bacteria, mitochondria, and chloroplasts. [Protein synthesis, Translation factors]


Pssm-ID: 272914 [Multi-domain]  Cd Length: 291  Bit Score: 139.53  E-value: 3.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  39 LLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHEQaqkeGWSKANKLEGRKAKEGLIGLFIRDKAAVMVEVNCETDFV 118
Cdd:TIGR00116   8 LVKELRERTGAGMMDCKKALVEANGDFEKAIKWLREK----GIAKAAKKADRVAAEGVIVLKSDNHKAVIVEVNSETDFV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 119 ARNEKFQQLVKDVAFATLAHHQDKnqskagyVKSVLAGDELNKLSVAEGASLAdhvaltiGRLGENMSVKRAVTVGIPAE 198
Cdd:TIGR00116  84 AKNEGFKEFANKLLDELKANPITT-------LEELQKQELENKEKVEYLASLA-------AKIGENIVLRRVAVLEGQSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525 199 WcIGSYVHGGvsgqtevamGRYGALVVFQGGKEEEqevLGRKLGQHIVGEAPVSLGNMD----------------DLPCG 262
Cdd:TIGR00116 150 V-IFSYLHAN---------ARIGVLVELKGKADEE---LAKHLAMHVAANKPQFIDQDDvsqewvkkerqiitdqAELSG 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1529987525 263 E-----------------SETRLLPQTFLGDPSRTVAQFLRGQQARVLDFVRFQCGETVSEEA 308
Cdd:TIGR00116 217 KpkeilekmvegrmkkflAEISLLGQKFVMDPSKTVGQFLKEKNAKVTEFVRFEVGEGIEKKA 279
tsf PRK12332
elongation factor Ts; Reviewed
38-132 8.15e-28

elongation factor Ts; Reviewed


Pssm-ID: 183447 [Multi-domain]  Cd Length: 198  Bit Score: 106.91  E-value: 8.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLheqaQKEGWSKANKLEGRKAKEGLIGLFIR--DKAAVMVEVNCET 115
Cdd:PRK12332    6 KLVKELREKTGAGMMDCKKALEEANGDMEKAIEWL----REKGLAKAAKKAGRVAAEGLVGSYIHtgGRIGVLVELNCET 81
                          90
                  ....*....|....*..
gi 1529987525 116 DFVARNEKFQQLVKDVA 132
Cdd:PRK12332   82 DFVARTEEFKELAKDIA 98
tsf CHL00098
elongation factor Ts
36-132 1.07e-22

elongation factor Ts


Pssm-ID: 214362  Cd Length: 200  Bit Score: 93.20  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1529987525  36 DKALLMKLRKTTGYTFINCKKALEKFDNDVTQAEswlhEQAQKEGWSKANKLEGRKAKEGLIGLFIR--DKAAVMVEVNC 113
Cdd:CHL00098    1 SAELVKELRDKTGAGMMDCKKALQEANGDFEKAL----ESLRQKGLASANKKSTRITTEGLIESYIHtgGKLGVLVEINC 76
                          90
                  ....*....|....*....
gi 1529987525 114 ETDFVARNEKFQQLVKDVA 132
Cdd:CHL00098   77 ETDFVARREEFQKLAKNIA 95
UBA_EF-Ts cd14275
UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria ...
38-74 2.23e-12

UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes; EF-Ts functions as a nucleotide exchange factor in the functional cycle of EF-Tu, another translation elongation factor that facilitates the binding of aminoacylated transfer RNAs (aminoacyl-tRNA) to the ribosomal A site as a ternary complex with guanosine triphosphate during the elongation cycle of protein biosynthesis, and then catalyzes the hydrolysis of GTP and release itself in GDP-bound form. EF-Ts forms complex with EF-Tu and catalyzes the nucleotide exchange reaction promoting the formation of EF-Tu in GTP-bound form from EF-Tu in GDP-bound form. EF-Ts from Thermus thermophiles is shorter than EF-Ts from Escherichia coli, but it has higher thermostability. The mitochondrial translational EF-Ts from chloroplasts and mitochondria display high similarity to the bacterial EF-Ts. The majority of family members contain one ubiquitin-associated (UBA) domain, but some family members from plants harbor two tandem UBA domains.


Pssm-ID: 270461 [Multi-domain]  Cd Length: 37  Bit Score: 60.48  E-value: 2.23e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1529987525  38 ALLMKLRKTTGYTFINCKKALEKFDNDVTQAESWLHE 74
Cdd:cd14275     1 ELIKELREKTGAGIMDCKKALEEANGDLEKAIEWLRK 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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