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Conserved domains on  [gi|1069350581|ref|XP_018115104|]
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fibronectin leucine rich transmembrane protein 1 S homeolog isoform X1 [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-335 3.63e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLPH--SLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGLP--HTLEELRLDDNRISTIPlhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 247 AD-DTFSRLQNLSELSLVRNslaappvNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNN-------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                         250
                  ....*....|
gi 1069350581 326 NLSQLLLRNN 335
Cdd:COG4886   336 TLTTLALSLS 345
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 307-385 7.30e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 7.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLIWLRDWVKAR-ASVVNVRGLMCQGPEKVRGMAIKDITQELDDC 385
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-91 9.23e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 9.23e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1069350581   61 CPYVCRCDNGFIYCNDRGLTSIPPDIPDDAT 91
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 446-514 4.83e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1069350581  446 LNVKPLTADSIRITWK--SFHPASSFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:smart00060   7 LRVTDVTSTSVTLSWEppPDDGITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-335 3.63e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLPH--SLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGLP--HTLEELRLDDNRISTIPlhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 247 AD-DTFSRLQNLSELSLVRNslaappvNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNN-------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                         250
                  ....*....|
gi 1069350581 326 NLSQLLLRNN 335
Cdd:COG4886   336 TLTTLALSLS 345
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-388 2.25e-22

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 102.47  E-value: 2.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  65 CRCDNGFIYCNDR-GLTSIPPDIPDDATTLYLQNNQINNagVPTELKTktNVKVIYLYENDLDEFPVNLPHSLRELHLQD 143
Cdd:PRK15370  175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 144 NNIRSVTRdslsRIPQ-IEKLHLDDNSVSTVSiedDAFLDshQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRIS---- 218
Cdd:PRK15370  251 NRITELPE----RLPSaLQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpe 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 219 TIPLhafkglnNLRRLVLDGNLLANqrIADDTFSRLQNlseLSLVRNSLAAPPVNLPSAhLQKLYLQDNAITHIPYNSLS 298
Cdd:PRK15370  322 TLPP-------GLKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPA 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 299 KmrqLQRLDLSSNNLTALPRGLFDDLENLSQ---LLLRNNPWfcgcnliwlrdwvkARASVVNVRGLMC----QGPEKVR 371
Cdd:PRK15370  389 A---LQIMQASRNNLVRLPESLPHFRGEGPQptrIIVEYNPF--------------SERTIQNMQRLMSsvgyQGPRVLF 451

                         330       340
                  ....*....|....*....|
gi 1069350581 372 GM---AIKDITQELDDCFEG 388
Cdd:PRK15370  452 AMgdfSIVRVTRPLHQAVQG 471
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-318 2.73e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 81.37  E-value: 2.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNAGvptELKTKTNVKVIYLYENDLDEFP--VNLPHsLRELHLQDNNIRSVtrDSLSRIPQIEKLHLDDN 168
Cdd:cd21340     5 THLYLNDKNITKID---NLSLCKNLKVLYLYDNKITKIEnlEFLTN-LTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVsiEDdafLDS-HQLRLLFLSRNHLssiPNGlphtlEELRLDDNRISTIplhafkgLNNLRRLVLDGNllanqria 247
Cdd:cd21340    79 RISVV--EG---LENlTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN-------- 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1069350581 248 ddtfsRLQNLSELSLVRNslaappvnlpsahLQKLYLQDNAITHIPY--NSLSKMRQLQRLDLSSNNLTALPR 318
Cdd:cd21340   131 -----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
278-336 8.08e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 8.08e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1069350581 278 HLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNNP 336
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 307-385 7.30e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 7.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLIWLRDWVKAR-ASVVNVRGLMCQGPEKVRGMAIKDITQELDDC 385
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
335-372 1.63e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1069350581  335 NPWFCGCNLIWLRDWVKARASVVNVRGLMCQGPEKVRG 372
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-91 9.23e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 9.23e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1069350581   61 CPYVCRCDNGFIYCNDRGLTSIPPDIPDDAT 91
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-87 3.00e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.16  E-value: 3.00e-06
                          10        20
                  ....*....|....*....|....*..
gi 1069350581  61 CPYVCRCDNGFIYCNDRGLTSIPPDIP 87
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 446-514 4.83e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1069350581  446 LNVKPLTADSIRITWK--SFHPASSFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:smart00060   7 LRVTDVTSTSVTLSWEppPDDGITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
446-514 1.08e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1069350581 446 LNVKPLTADSIRITWK-SFHPAS---SFRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTpPPDGNGpitGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 446-513 1.10e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1069350581 446 LNVKPLTADSIRITWK----SFHPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPRSTYIICLV 513
Cdd:cd00063     7 LRVTDVTSTSVTLSWTppedDGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
LRR smart00370
Leucine-rich repeats, outliers;
300-323 1.18e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....
gi 1069350581  300 MRQLQRLDLSSNNLTALPRGLFDD 323
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-335 3.63e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLPH--SLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGLP--HTLEELRLDDNRISTIPlhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 247 AD-DTFSRLQNLSELSLVRNslaappvNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNN-------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                         250
                  ....*....|
gi 1069350581 326 NLSQLLLRNN 335
Cdd:COG4886   336 TLTTLALSLS 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-335 1.20e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQinnagvptELKTKTNVKVIYLYENDLDEFPVNLP--HSLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886    99 TELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGL--PHTLEELRLDDNRISTIPLhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886   170 QLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN-----QL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 247 AD-DTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886   241 TDlPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         250
                  ....*....|
gi 1069350581 326 NLSQLLLRNN 335
Cdd:COG4886   321 TTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-388 2.25e-22

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 102.47  E-value: 2.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  65 CRCDNGFIYCNDR-GLTSIPPDIPDDATTLYLQNNQINNagVPTELKTktNVKVIYLYENDLDEFPVNLPHSLRELHLQD 143
Cdd:PRK15370  175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 144 NNIRSVTRdslsRIPQ-IEKLHLDDNSVSTVSiedDAFLDshQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRIS---- 218
Cdd:PRK15370  251 NRITELPE----RLPSaLQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpe 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 219 TIPLhafkglnNLRRLVLDGNLLANqrIADDTFSRLQNlseLSLVRNSLAAPPVNLPSAhLQKLYLQDNAITHIPYNSLS 298
Cdd:PRK15370  322 TLPP-------GLKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPA 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 299 KmrqLQRLDLSSNNLTALPRGLFDDLENLSQ---LLLRNNPWfcgcnliwlrdwvkARASVVNVRGLMC----QGPEKVR 371
Cdd:PRK15370  389 A---LQIMQASRNNLVRLPESLPHFRGEGPQptrIIVEYNPF--------------SERTIQNMQRLMSsvgyQGPRVLF 451

                         330       340
                  ....*....|....*....|
gi 1069350581 372 GM---AIKDITQELDDCFEG 388
Cdd:PRK15370  452 AMgdfSIVRVTRPLHQAVQG 471
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-346 2.72e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 109 LKTKTNVKVIYLYENDLDEFPVNLPHSLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTVSIEDDAFLDSHQLRL 188
Cdd:COG4886    21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 189 LFLSRN-HLSSIPNglphtLEELRLDDNRISTIPlHAFKGLNNLRRLVLDGNLLANqriADDTFSRLQNLSELSLVRNSL 267
Cdd:COG4886   101 LDLSGNeELSNLTN-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPEPLGNLTNLKSLDLSNNQL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 268 AAPPVNL-PSAHLQKLYLQDNAITHIPyNSLSKMRQLQRLDLSSNNLTALPRGLfDDLENLSQLLLRNN-----PWFCGC 341
Cdd:COG4886   172 TDLPEELgNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGNL 249


                  ....*.
gi 1069350581 342 -NLIWL 346
Cdd:COG4886   250 tNLEEL 255
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-318 2.73e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 81.37  E-value: 2.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNAGvptELKTKTNVKVIYLYENDLDEFP--VNLPHsLRELHLQDNNIRSVtrDSLSRIPQIEKLHLDDN 168
Cdd:cd21340     5 THLYLNDKNITKID---NLSLCKNLKVLYLYDNKITKIEnlEFLTN-LTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 169 SVSTVsiEDdafLDS-HQLRLLFLSRNHLssiPNGlphtlEELRLDDNRISTIplhafkgLNNLRRLVLDGNllanqria 247
Cdd:cd21340    79 RISVV--EG---LENlTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN-------- 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1069350581 248 ddtfsRLQNLSELSLVRNslaappvnlpsahLQKLYLQDNAITHIPY--NSLSKMRQLQRLDLSSNNLTALPR 318
Cdd:cd21340   131 -----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-337 2.94e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 2.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  72 IYCNDRGLTSIPPDIPDDA--TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNL--PHSLRELHLQDNNIR 147
Cdd:COG4886   141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 148 SVTrDSLSRIPQIEKLHLDDNSVSTVSieddAFLDSHQLRLLFLSRNHLSSIPNGLPHT-LEELRLDDNRISTIPLHAFK 226
Cdd:COG4886   219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 227 GLNNLRRLVLDGNLLANQriadDTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRL 306
Cdd:COG4886   294 LLLGLNSLLLLLLLLNLL----ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1069350581 307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPW 337
Cdd:COG4886   370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-335 2.48e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 2.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 139 LHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTvSIEDDAFLDSHQLRLLFLSRNHLS-SIPNGLPHTLEELRLDDNRI 217
Cdd:PLN00113   74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNML 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 218 S-TIPLHaFKGLNNLRRLVLDGNLLANQriADDTFSRLQNLSELSLVRNSLAAP-PVNLPSA-HLQKLYLQDNAIT-HIP 293
Cdd:PLN00113  153 SgEIPND-IGSFSSLKVLDLGGNVLVGK--IPNSLTNLTSLEFLTLASNQLVGQiPRELGQMkSLKWIYLGYNNLSgEIP 229

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1069350581 294 YnSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNN 335
Cdd:PLN00113  230 Y-EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR_8 pfam13855
Leucine rich repeat;
278-336 8.08e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 8.08e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1069350581 278 HLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNNP 336
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 139-335 1.07e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 139 LHLQDNNIRSvtrdslsripqIEKLHLddnsvstvsieddafldSHQLRLLFLSRNHLSSIPN--GLPHtLEELRLDDNR 216
Cdd:cd21340     7 LYLNDKNITK-----------IDNLSL-----------------CKNLKVLYLYDNKITKIENleFLTN-LTHLYLQNNQ 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 217 ISTIPlhAFKGLNNLRRLVLDGNLLAnqRIADdtFSRLQNLSELSLVRNSLAAPpvnlpsahlQKLYLQDNAIThipynS 296
Cdd:cd21340    58 IEKIE--NLENLVNLKKLYLGGNRIS--VVEG--LENLTNLEELHIENQRLPPG---------EKLTFDPRSLA-----A 117

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1069350581 297 LSKmrQLQRLDLSSNNLTALpRGLFDdLENLSQLLLRNN 335
Cdd:cd21340   118 LSN--SLRVLNISGNNIDSL-EPLAP-LRNLEQLDASNN 152
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-326 1.37e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  72 IYCNDRGLTSIPPDIPDDA--TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLP--HSLRELHLQDNNIR 147
Cdd:COG4886   164 LDLSNNQLTDLPEELGNLTnlKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLT 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 148 SVtrDSLSRIPQIEKLHLDDNSVSTVSIEddafLDSHQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRISTIPLHAFKG 227
Cdd:COG4886   242 DL--PELGNLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 228 LNNLRRLVLDGNLLANQRIADDTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLD 307
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                         250
                  ....*....|....*....
gi 1069350581 308 LSSNNLTALPRGLFDDLEN 326
Cdd:COG4886   396 TTAGVLLLTLALLDAVNTE 414
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 92-339 2.64e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 62.37  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  92 TLYLQNNQINNAGVPTELKTKTNVKVIYLYENDLDE-----FPVNLPH--SLRELHLQDNNIRSVTR------DSLSRIP 158
Cdd:cd00116     2 QLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEeaakaLASALRPqpSLKELCLSLNETGRIPRglqsllQGLTKGC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 159 QIEKLHLDDNSVStvsieddaFLDSHQLRLLFLSrnhlssipnglpHTLEELRLDDNRISTIPL-HAFKGLN----NLRR 233
Cdd:cd00116    82 GLQELDLSDNALG--------PDGCGVLESLLRS------------SSLQELKLNNNGLGDRGLrLLAKGLKdlppALEK 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 234 LVLDGNLLANQRIAD--DTFSRLQNLSELSLVRNSLAAPPVNL------PSAHLQKLYLQDNAITHIPYNSLS----KMR 301
Cdd:cd00116   142 LVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGIRAlaeglkANCNLEVLDLNNNGLTDEGASALAetlaSLK 221

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1069350581 302 QLQRLDLSSNNLTALP-RGLFDDLENLSQLLLRNNPWFC 339
Cdd:cd00116   222 SLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-335 5.51e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 5.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  82 IPPDI--PDDATTLYLQNNQINNAgVPTELKTKTNVKVIYLYENDLD-EFPVNLP--HSLRELHLQDNNIRSVTRDSLSR 156
Cdd:PLN00113  348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 157 IPQIEKLHLDDNSVSTvSIEDDAFlDSHQLRLLFLSRNHLSSipnGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNN 230
Cdd:PLN00113  427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 231 LRRLVLDGNLLANQriADDTFSRLQNLSELSLVRNSLAAppvnlpsahlqklylqdnaitHIPyNSLSKMRQLQRLDLSS 310
Cdd:PLN00113  501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556

                         250       260
                  ....*....|....*....|....*.
gi 1069350581 311 NNLTA-LPRGLfDDLENLSQLLLRNN 335
Cdd:PLN00113  557 NQLSGeIPKNL-GNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
206-267 8.12e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 8.12e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1069350581 206 TLEELRLDDNRISTIPLHAFKGLNNLRRLVLDGNLLanQRIADDTFSRLQNLSELSLVRNSL 267
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
69-314 1.98e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.95  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  69 NGFIYCNDRGLTSIPPDIPDDATTLYLQNNQINN-AGVPTELKT-------KTNVKV-------IYLYENDLDEFPVnLP 133
Cdd:PRK15387  203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRTlevsgnqLTSLPVlppglleLSIFSNPLTHLPA-LP 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 134 HSLRELHLQDNNIRSVTrdslSRIPQIEKLHLDDNSVSTVSIeddafLDShQLRLLFLSRNHLSSIPNgLPHTLEELRLD 213
Cdd:PRK15387  282 SGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLASLPA-----LPS-ELCKLWAYNNQLTSLPT-LPSGLQELSVS 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 214 DNRISTIP-----LHAFKGLNN-----------LRRLVLDGNLLANQRIADdtfsrlQNLSELSLVRNSLAAPPVnLPSA 277
Cdd:PRK15387  351 DNQLASLPtlpseLYKLWAYNNrltslpalpsgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LPSG 423

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1069350581 278 hLQKLYLQDNAITHIPyNSLSKMRQLQRLDLSSNNLT 314
Cdd:PRK15387  424 -LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-335 3.16e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 3.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  93 LYLQNNQINnAGVPTELKTKTNVKVIYLYENDLD-EFPVNLPH--SLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNS 169
Cdd:PLN00113  193 LTLASNQLV-GQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 170 VSTvSIEDDAFlDSHQLRLLFLSRNHLS-SIPNGLPH--TLEELRLDDNRIS-TIPLhAFKGLNNLRRLVLDGNLLANQR 245
Cdd:PLN00113  272 LSG-PIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQlqNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFSGEI 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 246 IADdtFSRLQNLSELSLVRNSLAA--PPVNLPSAHLQKLYLQDNAI-THIPyNSLSKMRQLQRLDLSSNNLTA-LPRGlF 321
Cdd:PLN00113  349 PKN--LGKHNNLTVLDLSTNNLTGeiPEGLCSSGNLFKLILFSNSLeGEIP-KSLGACRSLRRVRLQDNSFSGeLPSE-F 424

                         250
                  ....*....|....
gi 1069350581 322 DDLENLSQLLLRNN 335
Cdd:PLN00113  425 TKLPLVYFLDISNN 438
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-328 2.61e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 136 LRELHLQDNNIR---SVTRDSLSRIPQIEKLHLDDNSVST--VSIEDDAFLD-SHQLRLLFLSRNHLSS-----IPNGLP 204
Cdd:cd00116    83 LQELDLSDNALGpdgCGVLESLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDlPPALEKLVLGRNRLEGasceaLAKALR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 205 H--TLEELRLDDNRIST--IPL--HAFKGLNNLRRLVLDGNLLANQRIAD--DTFSRLQNLSELSLVRNSLAappvnlpS 276
Cdd:cd00116   163 AnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT-------D 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1069350581 277 AHLQKLYLQdnaithipynSLSKMRQLQRLDLSSNNLTA-----LPRGLFD--DLENLS 328
Cdd:cd00116   236 AGAAALASA----------LLSPNISLLTLSLSCNDITDdgakdLAEVLAEkeSLLELD 284
LRR_8 pfam13855
Leucine rich repeat;
230-313 3.88e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 230 NLRRLVLDGNLLanQRIADDTFSRLQNLselslvrnslaappvnlpsahlQKLYLQDNAITHIPYNSLSKMRQLQRLDLS 309
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKGLSNL----------------------KVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1069350581 310 SNNL 313
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
158-241 5.57e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 158 PQIEKLHLDDNSVStvSIEDDAFLDSHQLRLLFLSRNhlssipnglphtleelrlddnRISTIPLHAFKGLNNLRRLVLD 237
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNN---------------------LLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1069350581 238 GNLL 241
Cdd:pfam13855  58 GNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 307-385 7.30e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 7.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLIWLRDWVKAR-ASVVNVRGLMCQGPEKVRGMAIKDITQELDDC 385
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
335-372 1.63e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1069350581  335 NPWFCGCNLIWLRDWVKARASVVNVRGLMCQGPEKVRG 372
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG 38
LRR_8 pfam13855
Leucine rich repeat;
135-196 2.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1069350581 135 SLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTvsIEDDAFLDSHQLRLLFLSRNHL 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-91 9.23e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 9.23e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1069350581   61 CPYVCRCDNGFIYCNDRGLTSIPPDIPDDAT 91
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-87 3.00e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.16  E-value: 3.00e-06
                          10        20
                  ....*....|....*....|....*..
gi 1069350581  61 CPYVCRCDNGFIYCNDRGLTSIPPDIP 87
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
144-317 2.35e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 144 NNIRSVTRDSLSRIPQIEKLHlddnsVSTVSIEDDAFLD----SHQLRLLFLSRNHLSSIPNgLPHTLEELRLDDNRIST 219
Cdd:PRK15387  203 NAVLNVGESGLTTLPDCLPAH-----ITTLVIPDNNLTSlpalPPELRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTH 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 220 IPLHAfkglNNLRRLVLDGNLLANQRIADdtfsrlQNLSELSLVRNSLAAPPVnLPSaHLQKLYLQDNAITHIPynslSK 299
Cdd:PRK15387  277 LPALP----SGLCKLWIFGNQLTSLPVLP------PGLQELSVSDNQLASLPA-LPS-ELCKLWAYNNQLTSLP----TL 340

                         170
                  ....*....|....*...
gi 1069350581 300 MRQLQRLDLSSNNLTALP 317
Cdd:PRK15387  341 PSGLQELSVSDNQLASLP 358
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 91-217 2.58e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNAGV---PTELKTKTNVKVIYLYENDL-DEFPVNL------PHSLRELHLQDNNIRSVTRDSLSRI--- 157
Cdd:COG5238   267 ETLYLSGNQIGAEGAialAKALQGNTTLTSLDLSVNRIgDEGAIALaeglqgNKTLHTLNLAYNGIGAQGAIALAKAlqe 346

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1069350581 158 -PQIEKLHLDDNSVSTVSIEDDA-FLDSH-QLRLLFLSRNHLS-----SIPNGLPHT-LEELRLDDNRI 217
Cdd:COG5238   347 nTTLHSLDLSDNQIGDEGAIALAkYLEGNtTLRELNLGKNNIGkqgaeALIDALQTNrLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 254-335 3.04e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 254 LQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPynSLSKMRQLQRLDLSSNNLTALPrGLfDDLENLSQLLLR 333
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-NL-ENLVNLKKLYLG 76


                  ..
gi 1069350581 334 NN 335
Cdd:cd21340    77 GN 78
LRR_8 pfam13855
Leucine rich repeat;
301-335 3.05e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1069350581 301 RQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNN 335
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 446-514 4.83e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1069350581  446 LNVKPLTADSIRITWK--SFHPASSFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:smart00060   7 LRVTDVTSTSVTLSWEppPDDGITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 91-324 7.54e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581  91 TTLYLQNNQINNAGVP---TELKTKTNVKVIYLYENDL-DEFPVNL------PHSLRELHLQDNNIRSVTRDSLSRipqi 160
Cdd:COG5238   211 TTLWLKRNPIGDEGAEilaEALKGNKSLTTLDLSNNQIgDEGVIALaealknNTTVETLYLSGNQIGAEGAIALAK---- 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 161 eklHLDDNSvstvsieddafldshQLRLLFLSRNHLS-----SIPNGLPH--TLEELRLDDNRIST---IPL-HAFKGLN 229
Cdd:COG5238   287 ---ALQGNT---------------TLTSLDLSVNRIGdegaiALAEGLQGnkTLHTLNLAYNGIGAqgaIALaKALQENT 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 230 NLRRLVLDGNLLANQRIAddtfsrlqnlselslvrnSLAAPPVNLPSAHlqKLYLQDNAITHIPYNSLSKM---RQLQRL 306
Cdd:COG5238   349 TLHSLDLSDNQIGDEGAI------------------ALAKYLEGNTTLR--ELNLGKNNIGKQGAEALIDAlqtNRLHTL 408

                         250
                  ....*....|....*...
gi 1069350581 307 DLSSNNLTALPRGLFDDL 324
Cdd:COG5238   409 ILDGNLIGAEAQQRLEQL 426
fn3 pfam00041
Fibronectin type III domain;
446-514 1.08e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1069350581 446 LNVKPLTADSIRITWK-SFHPAS---SFRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTpPPDGNGpitGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 446-513 1.10e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1069350581 446 LNVKPLTADSIRITWK----SFHPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPRSTYIICLV 513
Cdd:cd00063     7 LRVTDVTSTSVTLSWTppedDGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
LRR smart00370
Leucine-rich repeats, outliers;
300-323 1.18e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....
gi 1069350581  300 MRQLQRLDLSSNNLTALPRGLFDD 323
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
300-323 1.18e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....
gi 1069350581  300 MRQLQRLDLSSNNLTALPRGLFDD 323
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_9 pfam14580
Leucine-rich repeat;
156-271 2.96e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 156 RIPQIEKLhlddnsvstvsiedDAFLDshQLRLLFLSRNHLSSIpNGLPHT--LEELRLDDNRISTIPLHAFKGLNNLRR 233
Cdd:pfam14580  30 KIPIIENL--------------GATLD--QFDTIDFSDNEIRKL-DGFPLLrrLKTLLLNNNRICRIGEGLGEALPNLTE 92

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1069350581 234 LVLDGNLLanQRIAD-DTFSRLQNLSELSLVRNSLAAPP 271
Cdd:pfam14580  93 LILTNNNL--QELGDlDPLASLKKLTFLSLLRNPVTNKP 129
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 278-313 5.52e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1069350581 278 HLQKLYLQDNAITHIPynSLSKMRQLQRLDLSSNNL 313
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 221-340 7.40e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 221 PLHAFKGLN-----NLRRLVLDGNLLANQRIAD---DTFSRLQNLSELSLVRNSL-AAPPVNLPS-AHLQKLYLQDNAIT 290
Cdd:PLN03150  400 QQHPWSGADcqfdsTKGKWFIDGLGLDNQGLRGfipNDISKLRHLQSINLSGNSIrGNIPPSLGSiTSLEVLDLSYNSFN 479

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1069350581 291 HIPYNSLSKMRQLQRLDLSSNNLTA-LPRGLFDDLENLSQLLLRNNPWFCG 340
Cdd:PLN03150  480 GSIPESLGQLTSLRILNLNGNSLSGrVPAALGGRLLHRASFNFTDNAGLCG 530
LRR_8 pfam13855
Leucine rich repeat;
113-168 9.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 9.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069350581 113 TNVKVIYLYENDL----DEFPVNLPHsLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDN 168
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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