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Conserved domains on  [gi|1059154131|ref|XP_017733389|]
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PREDICTED: solute carrier family 35 member C2 isoform X2 [Rhinopithecus bieti]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT_S35C2 super family cl40580
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 80-326 7.12e-68

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


The actual alignment was detected with superfamily member cd21092:

Pssm-ID: 411044  Cd Length: 248  Bit Score: 214.06  E-value: 7.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  80 WADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKLAAtaphptsarhwswwsss 159
Cdd:cd21092     1 WSDYLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKSSAIIFILFFSLVFKLEKPRWSLVL----------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 160 spgVSSCSPTSPHSSTWRALPWCWGPHSSVAFAGPSprcSCRRLNLASRIP-------STPCSTCSHSCSW--------- 223
Cdd:cd21092    64 ---VVLLIAGGLFMFTYKSTQFNLEGFILVLSASFL---GGLRWTLAQLLMqkaelglQNPIDMMYHLQPWmilgllpla 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 224 --------GSSLSLLYLKDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS 295
Cdd:cd21092   138 igfeglhlATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSIAGIFKEICTLLLAVHINGDHLS 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1059154131 296 LLNWLGFALCLSGISLHVALKALHSRGDGGP 326
Cdd:cd21092   218 LLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
TPT super family cl26744
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-140 4.94e-07

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


The actual alignment was detected with superfamily member pfam03151:

Pssm-ID: 474852 [Multi-domain]  Cd Length: 290  Bit Score: 50.75  E-value: 4.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  16 LTLGLV-LLYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRALvqcsSHRARVVLSWAdYLRRVAPTALAT 94
Cdd:pfam03151   1 LKLGLLfGLWYFLNIYFNIYNKKILNAFPYPMTVSSVQLFVGSVYILVLWGT----GLRKRPKISSP-FLKNILPLALCH 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1059154131  95 ALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKL 140
Cdd:pfam03151  76 TLGHVLANVSLGKVAVSFTHTVKAMEPFFTVILSRLFLGEYPPLLV 121
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 80-326 7.12e-68

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 214.06  E-value: 7.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  80 WADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKLAAtaphptsarhwswwsss 159
Cdd:cd21092     1 WSDYLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKSSAIIFILFFSLVFKLEKPRWSLVL----------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 160 spgVSSCSPTSPHSSTWRALPWCWGPHSSVAFAGPSprcSCRRLNLASRIP-------STPCSTCSHSCSW--------- 223
Cdd:cd21092    64 ---VVLLIAGGLFMFTYKSTQFNLEGFILVLSASFL---GGLRWTLAQLLMqkaelglQNPIDMMYHLQPWmilgllpla 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 224 --------GSSLSLLYLKDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS 295
Cdd:cd21092   138 igfeglhlATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSIAGIFKEICTLLLAVHINGDHLS 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1059154131 296 LLNWLGFALCLSGISLHVALKALHSRGDGGP 326
Cdd:cd21092   218 LLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-140 4.94e-07

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 50.75  E-value: 4.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  16 LTLGLV-LLYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRALvqcsSHRARVVLSWAdYLRRVAPTALAT 94
Cdd:pfam03151   1 LKLGLLfGLWYFLNIYFNIYNKKILNAFPYPMTVSSVQLFVGSVYILVLWGT----GLRKRPKISSP-FLKNILPLALCH 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1059154131  95 ALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKL 140
Cdd:pfam03151  76 TLGHVLANVSLGKVAVSFTHTVKAMEPFFTVILSRLFLGEYPPLLV 121
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 16-140 1.77e-03

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 39.71  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  16 LTLGLVL-LYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRAlvqcSSHRARVVLSWAdYLRRVAPTALAT 94
Cdd:TIGR00817   1 LQTGLLFgLWYFLNVYFNIYNKKLLNVFPYPYFKTLISLAVGSLYCLLSWS----SGLPKRLKISSA-LLKLLLPVAIVH 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1059154131  95 ALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKL 140
Cdd:TIGR00817  76 TIGHVTSNVSLSKVAVSFTHTIKAMEPFFSVVLSAFFLGQEFPSTL 121
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 80-326 7.12e-68

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 214.06  E-value: 7.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  80 WADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKLAAtaphptsarhwswwsss 159
Cdd:cd21092     1 WSDYLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKSSAIIFILFFSLVFKLEKPRWSLVL----------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 160 spgVSSCSPTSPHSSTWRALPWCWGPHSSVAFAGPSprcSCRRLNLASRIP-------STPCSTCSHSCSW--------- 223
Cdd:cd21092    64 ---VVLLIAGGLFMFTYKSTQFNLEGFILVLSASFL---GGLRWTLAQLLMqkaelglQNPIDMMYHLQPWmilgllpla 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131 224 --------GSSLSLLYLKDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS 295
Cdd:cd21092   138 igfeglhlATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSIAGIFKEICTLLLAVHINGDHLS 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1059154131 296 LLNWLGFALCLSGISLHVALKALHSRGDGGP 326
Cdd:cd21092   218 LLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-140 4.94e-07

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 50.75  E-value: 4.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  16 LTLGLV-LLYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRALvqcsSHRARVVLSWAdYLRRVAPTALAT 94
Cdd:pfam03151   1 LKLGLLfGLWYFLNIYFNIYNKKILNAFPYPMTVSSVQLFVGSVYILVLWGT----GLRKRPKISSP-FLKNILPLALCH 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1059154131  95 ALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKL 140
Cdd:pfam03151  76 TLGHVLANVSLGKVAVSFTHTVKAMEPFFTVILSRLFLGEYPPLLV 121
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 16-140 1.77e-03

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 39.71  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1059154131  16 LTLGLVL-LYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFSALSRAlvqcSSHRARVVLSWAdYLRRVAPTALAT 94
Cdd:TIGR00817   1 LQTGLLFgLWYFLNVYFNIYNKKLLNVFPYPYFKTLISLAVGSLYCLLSWS----SGLPKRLKISSA-LLKLLLPVAIVH 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1059154131  95 ALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELTPKL 140
Cdd:TIGR00817  76 TIGHVTSNVSLSKVAVSFTHTIKAMEPFFSVVLSAFFLGQEFPSTL 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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