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Conserved domains on  [gi|1050601017|ref|XP_017622906|]
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caffeoylshikimate esterase [Gossypium arboreum]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 3-312 0e+00

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02298:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 330  Bit Score: 601.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017   3 EQEENLHYWGDISEEEYYRLQGIKGSKSFYTSPRGLSLFTRSWLPLS-GPPRGIIFGIHGYGNDISWTFQSTSIFLAQKG 81
Cdd:PLN02298    8 ATETEVHFWGETPEEEYYALKGIKGSKSFFTSPRGLSLFTRSWLPSSsSPPRALIFMVHGYGNDISWTFQSTAIFLAQMG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  82 FACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNGFQGAVLVAP 161
Cdd:PLN02298   88 FACFALDLEGHGRSEGLRAYVPNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 162 MCKISDKVRPRWPIPQALTFISNFLPTLAIVPTEDLLHKSIKVEEKKIVGNKNPVRYRGKPRLGTVVELLRVTQLLSEKL 241
Cdd:PLN02298  168 MCKISDKIRPPWPIPQILTFVARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKL 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1050601017 242 RDVSIPFLVVHGSADVVTDPEVSRTLYKEASSQDKTLKIYEGMWHSLLFGEPDENIEIVRTDILSWLSDRC 312
Cdd:PLN02298  248 KDVSIPFIVLHGSADVVTDPDVSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNERC 318
 
Name Accession Description Interval E-value
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 3-312 0e+00

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 601.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017   3 EQEENLHYWGDISEEEYYRLQGIKGSKSFYTSPRGLSLFTRSWLPLS-GPPRGIIFGIHGYGNDISWTFQSTSIFLAQKG 81
Cdd:PLN02298    8 ATETEVHFWGETPEEEYYALKGIKGSKSFFTSPRGLSLFTRSWLPSSsSPPRALIFMVHGYGNDISWTFQSTAIFLAQMG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  82 FACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNGFQGAVLVAP 161
Cdd:PLN02298   88 FACFALDLEGHGRSEGLRAYVPNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 162 MCKISDKVRPRWPIPQALTFISNFLPTLAIVPTEDLLHKSIKVEEKKIVGNKNPVRYRGKPRLGTVVELLRVTQLLSEKL 241
Cdd:PLN02298  168 MCKISDKIRPPWPIPQILTFVARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKL 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1050601017 242 RDVSIPFLVVHGSADVVTDPEVSRTLYKEASSQDKTLKIYEGMWHSLLFGEPDENIEIVRTDILSWLSDRC 312
Cdd:PLN02298  248 KDVSIPFIVLHGSADVVTDPDVSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNERC 318
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 50-294 9.63e-69

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 214.00  E-value: 9.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  50 GPPRGIIFGIHGYGnDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDpnFGALP 129
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREE--HPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 130 CFLYGESMGGALCLLVHFADPNGFQGAVLVAPMCKISDKVrPRWPIPQALTFISNFLPTLAiVPTEDLLHKSIK----VE 205
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYL-APPILKLLAKLLGKLFPRLR-VPNNLLPDSLSRdpevVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 206 EKKivgnKNPvRYRGKPRLGTVVELLRVTQLLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYKEASSQDKTLKIYEGMW 285
Cdd:pfam12146 156 AYA----ADP-LVHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLY 230


                  ....*....
gi 1050601017 286 HSLLFgEPD 294
Cdd:pfam12146 231 HELLN-EPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
31-310 6.38e-44

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 149.77  E-value: 6.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  31 FYTSPRGLSLFTRSWLPlSGPPRGIIFGIHGYGnDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQ 110
Cdd:COG2267     7 TLPTRDGLRLRGRRWRP-AGSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 111 DCLSFFNLIKQDPNfgaLPCFLYGESMGGALCLLVHFADPNGFQGAVLVAPmckisdkvrprwpipqaltfisnflptla 190
Cdd:COG2267    85 DLRAALDALRARPG---LPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP----------------------------- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 191 ivptedllhksikveekkivgnknpvRYRGKPRLGTVVELLRVTQlLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYkE 270
Cdd:COG2267   133 --------------------------AYRADPLLGPSARWLRALR-LAEALARIDVPVLVLHGGADRVVPPEAARRLA-A 184

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1050601017 271 ASSQDKTLKIYEGMWHSLLFgepDENIEIVRTDILSWLSD 310
Cdd:COG2267   185 RLSPDVELVLLPGARHELLN---EPAREEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 77-309 4.40e-10

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 59.80  E-value: 4.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  77 LAQKGFACFALDMEGHGRSQG---LRGYVPHVDLVVQDCLSFFNLIKQ-------------DPNF-----GALPCFLYGE 135
Cdd:TIGR01607  70 FNKNGYSVYGLDLQGHGESDGlqnLRGHINCFDDLVYDVIQYMNRINDsiilenetksddeSYDIvntkeNRLPMYIIGL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 136 SMGGALCLLV--------HFADPNGFQGAVLVAPMCKIS-----DKVRPRWPIPQALTFISNFLPTlaivpteDLLHKSI 202
Cdd:TIGR01607 150 SMGGNIALRLlellgksnENNDKLNIKGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPT-------FRISKKI 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 203 KVEEKKIVG---NKNPVRYRGKPRLGTVVELLRVTQLLSEKLRDV--SIPFLVVHGSADVVTDPEVSRTLYKEASSQDKT 277
Cdd:TIGR01607 223 RYEKSPYVNdiiKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKE 302

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1050601017 278 LKIYEGMWHSLLFGEPDENieiVRTDILSWLS 309
Cdd:TIGR01607 303 LHTLEDMDHVITIEPGNEE---VLKKIIEWIS 331
 
Name Accession Description Interval E-value
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 3-312 0e+00

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 601.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017   3 EQEENLHYWGDISEEEYYRLQGIKGSKSFYTSPRGLSLFTRSWLPLS-GPPRGIIFGIHGYGNDISWTFQSTSIFLAQKG 81
Cdd:PLN02298    8 ATETEVHFWGETPEEEYYALKGIKGSKSFFTSPRGLSLFTRSWLPSSsSPPRALIFMVHGYGNDISWTFQSTAIFLAQMG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  82 FACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNGFQGAVLVAP 161
Cdd:PLN02298   88 FACFALDLEGHGRSEGLRAYVPNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 162 MCKISDKVRPRWPIPQALTFISNFLPTLAIVPTEDLLHKSIKVEEKKIVGNKNPVRYRGKPRLGTVVELLRVTQLLSEKL 241
Cdd:PLN02298  168 MCKISDKIRPPWPIPQILTFVARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKL 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1050601017 242 RDVSIPFLVVHGSADVVTDPEVSRTLYKEASSQDKTLKIYEGMWHSLLFGEPDENIEIVRTDILSWLSDRC 312
Cdd:PLN02298  248 KDVSIPFIVLHGSADVVTDPDVSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNERC 318
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 24-315 4.48e-112

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 328.64  E-value: 4.48e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  24 GIKGSKSFYTSPRGLSLFTRSWLPLSGPPRGIIFGIHGYGNDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVP 103
Cdd:PLN02385   58 GIKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIP 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 104 HVDLVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNGFQGAVLVAPMCKISDKVRPRWPIPQALTFIS 183
Cdd:PLN02385  138 SFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLA 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 184 NFLPTLAIVPTEDLLHKSIKVEEKKIVGNKNPVRYRGKPRLGTVVELLRVTQLLSEKLRDVSIPFLVVHGSADVVTDPEV 263
Cdd:PLN02385  218 NLLPKAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSV 297

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1050601017 264 SRTLYKEASSQDKTLKIYEGMWHSLLFGEPDENIEIVRTDILSWLSDRCNTK 315
Cdd:PLN02385  298 SKFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSHSTQK 349
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 50-294 9.63e-69

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 214.00  E-value: 9.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  50 GPPRGIIFGIHGYGnDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDpnFGALP 129
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREE--HPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 130 CFLYGESMGGALCLLVHFADPNGFQGAVLVAPMCKISDKVrPRWPIPQALTFISNFLPTLAiVPTEDLLHKSIK----VE 205
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYL-APPILKLLAKLLGKLFPRLR-VPNNLLPDSLSRdpevVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 206 EKKivgnKNPvRYRGKPRLGTVVELLRVTQLLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYKEASSQDKTLKIYEGMW 285
Cdd:pfam12146 156 AYA----ADP-LVHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLY 230


                  ....*....
gi 1050601017 286 HSLLFgEPD 294
Cdd:pfam12146 231 HELLN-EPD 238
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 23-311 2.10e-48

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 166.61  E-value: 2.10e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  23 QGIKGSKSFYTSPRGLSLFTRSWLPLSGPPRGIIFGIHGYgNDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYV 102
Cdd:PLN02652  106 EGTRWATSLFYGARRNALFCRSWAPAAGEMRGILIIIHGL-NEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYV 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 103 PHVDLVVQDCLSFFNLIKQDpNFGaLPCFLYGESMGGALCLLV----HFADPngFQGAVLVAPMCkisdKVRPRWPIPQA 178
Cdd:PLN02652  185 PSLDYVVEDTEAFLEKIRSE-NPG-VPCFLFGHSTGGAVVLKAasypSIEDK--LEGIVLTSPAL----RVKPAHPIVGA 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 179 LTFISNFL-PTLAIVPTEdllHKSIKVE---EKKIVGNKNPVRYRGKPRLGTVVELLRVTQLLSEKLRDVSIPFLVVHGS 254
Cdd:PLN02652  257 VAPIFSLVaPRFQFKGAN---KRGIPVSrdpAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGT 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1050601017 255 ADVVTDPEVSRTLYKEASSQDKTLKIYEGMWHSLLFgEPDEniEIVRTDILSWLSDR 311
Cdd:PLN02652  334 ADRVTDPLASQDLYNEAASRHKDIKLYDGFLHDLLF-EPER--EEVGRDIIDWMEKR 387
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
31-310 6.38e-44

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 149.77  E-value: 6.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  31 FYTSPRGLSLFTRSWLPlSGPPRGIIFGIHGYGnDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQ 110
Cdd:COG2267     7 TLPTRDGLRLRGRRWRP-AGSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 111 DCLSFFNLIKQDPNfgaLPCFLYGESMGGALCLLVHFADPNGFQGAVLVAPmckisdkvrprwpipqaltfisnflptla 190
Cdd:COG2267    85 DLRAALDALRARPG---LPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP----------------------------- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 191 ivptedllhksikveekkivgnknpvRYRGKPRLGTVVELLRVTQlLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYkE 270
Cdd:COG2267   133 --------------------------AYRADPLLGPSARWLRALR-LAEALARIDVPVLVLHGGADRVVPPEAARRLA-A 184

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1050601017 271 ASSQDKTLKIYEGMWHSLLFgepDENIEIVRTDILSWLSD 310
Cdd:COG2267   185 RLSPDVELVLLPGARHELLN---EPAREEVLAAILAWLER 221
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
32-308 6.52e-26

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 102.79  E-value: 6.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  32 YTSPRGLSLFTRSWLPLSGPPRGIIFGIHGYGNDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPhvdlvVQD 111
Cdd:COG1506     2 FKSADGTTLPGWLYLPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDE-----VDD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 112 CLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNGFQGAVLVAPmckISDkvrprwpIPQALTFISNFLPTLAI 191
Cdd:COG1506    77 VLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAG---VSD-------LRSYYGTTREYTERLMG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 192 VPTEDllhksikveeKKIVGNKNPVRYrgkprlgtvvellrvtqllsekLRDVSIPFLVVHGSADVVTDPEVSRTLYKEA 271
Cdd:COG1506   147 GPWED----------PEAYAARSPLAY----------------------ADKLKTPLLLIHGEADDRVPPEQAERLYEAL 194

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1050601017 272 SSQ--DKTLKIYEGMWHSLLfgepDENIEIVRTDILSWL 308
Cdd:COG1506   195 KKAgkPVELLVYPGEGHGFS----GAGAPDYLERILDFL 229
PHA02857 PHA02857
monoglyceride lipase; Provisional
 40-313 2.05e-25

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 102.66  E-value: 2.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  40 LFTRSWLPlSGPPRGIIFGIHGYGNDiSWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLI 119
Cdd:PHA02857   13 IYCKYWKP-ITYPKALVFISHGAGEH-SGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVVQHVVTI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 120 KQD-PNfgaLPCFLYGESMGGALCLLVHFADPNGFQGAVLVAPMckISDKVRPRWPIPQalTFISNFLPTLAIVPTEDLL 198
Cdd:PHA02857   91 KSTyPG---VPVFLLGHSMGATISILAAYKNPNLFTAMILMSPL--VNAEAVPRLNLLA--AKLMGIFYPNKIVGKLCPE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 199 HKSIKVEEKKIVgNKNPVRYRGKPRLGTVVELLRVTQLLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYKEASSqDKTL 278
Cdd:PHA02857  164 SVSRDMDEVYKY-QYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREI 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1050601017 279 KIYEGMWHSlLFGEPDENIEIVRTDILSWLSDRCN 313
Cdd:PHA02857  242 KIYEGAKHH-LHKETDEVKKSVMKEIETWIFNRVK 275
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
48-308 5.39e-22

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 92.70  E-value: 5.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  48 LSGPPRGIIFgIHGYGndiswtfqSTSI-------FLAQKGFACFALDMEGHGRSQGlrgyvphvDLV---VQDCLSF-- 115
Cdd:COG1647    11 LEGGRKGVLL-LHGFT--------GSPAemrplaeALAKAGYTVYAPRLPGHGTSPE--------DLLkttWEDWLEDve 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 116 --FNLIKQDPNfgalPCFLYGESMGGALCLLV--HFADPngfQGAVLVAPMCKISDKVRPRWPIpqaLTFISNFLPTLAI 191
Cdd:COG1647    74 eaYEILKAGYD----KVIVIGLSMGGLLALLLaaRYPDV---AGLVLLSPALKIDDPSAPLLPL---LKYLARSLRGIGS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 192 VPtedllhKSIKVEEKKIvgNKNPVRyrgkprlgTVVELLRVTQLLSEKLRDVSIPFLVVHGSADVVTDPEVSRTLYKEA 271
Cdd:COG1647   144 DI------EDPEVAEYAY--DRTPLR--------ALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERL 207

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1050601017 272 SSQDKTLKIYEGMWHSLLFgepDENIEIVRTDILSWL 308
Cdd:COG1647   208 GSPDKELVWLEDSGHVITL---DKDREEVAEEILDFL 241
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 19-308 2.01e-18

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 83.04  E-value: 2.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  19 YYRLQGIKGSKSFYTSPRGLSLFTRSWLP-LSGPPRGIIFGIHGYGNDISWTFQSTSIFlAQKGFACFALDMEGHGRSQG 97
Cdd:COG1073     2 FPPSDKVNKEDVTFKSRDGIKLAGDLYLPaGASKKYPAVVVAHGNGGVKEQRALYAQRL-AELGFNVLAFDYRGYGESEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  98 LRGYVphVDLVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPNgFQGAVLVAPMCKISDKVRPRWpipq 177
Cdd:COG1073    81 EPREE--GSPERRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPFTSLEDLAAQRA---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 178 altfisnflptlaivptedllhksikveeKKIVGNKNP-VRYRgkPRLgTVVELLRVTQLLSEKLRDVSIPFLVVHGSAD 256
Cdd:COG1073   154 -----------------------------KEARGAYLPgVPYL--PNV-RLASLLNDEFDPLAKIEKISRPLLFIHGEKD 201

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1050601017 257 VVTDPEVSRTLYkEASSQDKTLKIYEGMWHSLLFgepDENIEIVRTDILSWL 308
Cdd:COG1073   202 EAVPFYMSEDLY-EAAAEPKELLIVPGAGHVDLY---DRPEEEYFDKLAEFF 249
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 28-309 3.84e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 70.42  E-value: 3.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  28 SKSFYTSPRGLSLFTRSWLPlSGPPrgIIFgIHGYGNDI-SWTFQstsIFLAQKGFACFALDMEGHGRSQGLRGYVpHVD 106
Cdd:COG0596     2 STPRFVTVDGVRLHYREAGP-DGPP--VVL-LHGLPGSSyEWRPL---IPALAAGYRVIAPDLRGHGRSDKPAGGY-TLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 107 LVVQDCLSFFNLIKQDPnfgalpCFLYGESMGGALCLLVHFADPNGFQGAVLVAPMCK-ISDKVRPRWPIPQAltfisnF 185
Cdd:COG0596    74 DLADDLAALLDALGLER------VVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAaLAEPLRRPGLAPEA------L 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 186 LPTLAIVPTEDllhksikveekkivgnknpvryrgkprlgtvvellrvtqlLSEKLRDVSIPFLVVHGSADVVTDPEVSR 265
Cdd:COG0596   142 AALLRALARTD----------------------------------------LRERLARITVPTLVIWGEKDPIVPPALAR 181

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1050601017 266 TLYKEASsqDKTLKIYEGMWHSLLFGEPDEnieiVRTDILSWLS 309
Cdd:COG0596   182 RLAELLP--NAELVVLPGAGHFPPLEQPEA----FAAALRDFLA 219
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 77-309 4.40e-10

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 59.80  E-value: 4.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  77 LAQKGFACFALDMEGHGRSQG---LRGYVPHVDLVVQDCLSFFNLIKQ-------------DPNF-----GALPCFLYGE 135
Cdd:TIGR01607  70 FNKNGYSVYGLDLQGHGESDGlqnLRGHINCFDDLVYDVIQYMNRINDsiilenetksddeSYDIvntkeNRLPMYIIGL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 136 SMGGALCLLV--------HFADPNGFQGAVLVAPMCKIS-----DKVRPRWPIPQALTFISNFLPTlaivpteDLLHKSI 202
Cdd:TIGR01607 150 SMGGNIALRLlellgksnENNDKLNIKGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPT-------FRISKKI 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 203 KVEEKKIVG---NKNPVRYRGKPRLGTVVELLRVTQLLSEKLRDV--SIPFLVVHGSADVVTDPEVSRTLYKEASSQDKT 277
Cdd:TIGR01607 223 RYEKSPYVNdiiKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKE 302

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1050601017 278 LKIYEGMWHSLLFGEPDENieiVRTDILSWLS 309
Cdd:TIGR01607 303 LHTLEDMDHVITIEPGNEE---VLKKIIEWIS 331
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 55-293 2.17e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.05  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  55 IIFgIHGYGnDISWTFQSTSIFLAQKGFACFALDMEGHGRSQGLRGYVPHVDLVVQDCLSFFNLIKQDPNFgalpcFLYG 134
Cdd:pfam00561   3 VLL-LHGLP-GSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKV-----NLVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 135 ESMGGALCLLVHFADPNGFQGAVLVAPMC---KISDKVRPRWPIPQ-------ALTFISNFLPTLAIVPTEDLLHKSIKV 204
Cdd:pfam00561  76 HSMGGLIALAYAAKYPDRVKALVLLGALDpphELDEADRFILALFPgffdgfvADFAPNPLGRLVAKLLALLLLRLRLLK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 205 EEKKIVGNKNPVRYRGKPRLGTVVELLRV---TQLLSEKLRDVSIPFLVVHGSADVVTDPEVSRtLYKEASSQdKTLKIY 281
Cdd:pfam00561 156 ALPLLNKRFPSGDYALAKSLVTGALLFIEtwsTELRAKFLGRLDEPTLIIWGDQDPLVPPQALE-KLAQLFPN-ARLVVI 233

                         250
                  ....*....|..
gi 1050601017 282 EGMWHSLLFGEP 293
Cdd:pfam00561 234 PDAGHFAFLEGP 245
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 55-295 2.43e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 50.55  E-value: 2.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  55 IIFgIHGYGNDISWTFQstsifLAQKGFACFALDMEGHGRSQGlrgyvPHVDLV-VQDCLSFFNLIKQDPNFgalpcFLY 133
Cdd:pfam12697   1 VVL-VHGAGLSAAPLAA-----LLAAGVAVLAPDLPGHGSSSP-----PPLDLAdLADLAALLDELGAARPV-----VLV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 134 GESMGGALCLlvHFADPNGFQGAVLVAPMCKISDKVRPRWPIPQALTFISNFLPTLAIVPTEDLLHKSIKVEEKKivgnk 213
Cdd:pfam12697  65 GHSLGGAVAL--AAAAAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWA----- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 214 npVRYRGKPRLGTVVELLRVtqllsEKLRDVSIPFLVVHGsadvvTDPEVSRTLYKE-ASSQDKTLKIYEGMWHSLLFgE 292
Cdd:pfam12697 138 --AALARLAALLAALALLPL-----AAWRDLPVPVLVLAE-----EDRLVPELAQRLlAALAGARLVVLPGAGHLPLD-D 204


                  ...
gi 1050601017 293 PDE 295
Cdd:pfam12697 205 PEE 207
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
76-160 1.72e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 48.73  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  76 FLAQKGFACFALDMEGHGRS--QGLRG----YvphVDLVVQDCLSFFNLIKQdpNFGALPCFLYGESMGG-ALCLLvhfA 148
Cdd:COG4757    54 YLAERGFAVLTYDYRGIGLSrpGSLRGfdagY---RDWGELDLPAVLDALRA--RFPGLPLLLVGHSLGGqLLGLA---P 125

                          90
                  ....*....|..
gi 1050601017 149 DPNGFQGAVLVA 160
Cdd:COG4757   126 NAERVDRLVTVA 137
PRK10749 PRK10749
lysophospholipase L2; Provisional
 77-173 2.24e-05

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 45.37  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  77 LAQKGFACFALDMEGHGRSQGL-----RGYVPHVDLVVQDclsFFNLIKQDpnfgALP-----CFLYGESMGGALCLLVH 146
Cdd:PRK10749   77 LFHLGYDVLIIDHRGQGRSGRLlddphRGHVERFNDYVDD---LAAFWQQE----IQPgpyrkRYALAHSMGGAILTLFL 149

                          90       100
                  ....*....|....*....|....*..
gi 1050601017 147 FADPNGFQGAVLVAPMCKISDKVrPRW 173
Cdd:PRK10749  150 QRHPGVFDAIALCAPMFGIVLPL-PSW 175
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
32-196 1.57e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 42.26  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017  32 YTSPRGLSLFTRSWLPLSGPPRGIIFGIHGYG--NDiswTFQSTSIFLAQKGFACFALDMEGHGRSQG----LRGYVPHV 105
Cdd:COG0412     8 IPTPDGVTLPGYLARPAGGGPRPGVVVLHEIFglNP---HIRDVARRLAAAGYVVLAPDLYGRGGPGDdpdeARALMGAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050601017 106 D--LVVQDCLSFFNLIKQDPNFGALPCFLYGESMGGALCLLVHFADPnGFQGAVLVAPMCkISDKVRPRWPIPQAltfis 183
Cdd:COG0412    85 DpeLLAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARGP-DLAAAVSFYGGL-PADDLLDLAARIKA----- 157

                         170
                  ....*....|...
gi 1050601017 184 nflPTLAIVPTED 196
Cdd:COG0412   158 ---PVLLLYGEKD 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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