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Conserved domains on  [gi|1046865904|ref|XP_017456061|]
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tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2 [Rattus norvegicus]

Protein Classification

RsmB/NOP family class I SAM-dependent RNA methyltransferase( domain architecture ID 11414805)

RsmB/NOP family class I SAM-dependent RNA methyltransferase similar to tRNA (cytosine(34)-C(5))-methyltransferase, which methylates cytosine at specific positions of intron-containing tRNA(Leu)(CAA) precursors and tRNA(Gly)(GCC) precursors

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0003723
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 46-324 1.98e-74

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 237.98  E-value: 1.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  46 LSHPPLftTVRVNTHLGSVEhvrgllleELQKQFGGSSIPVLQHPALPDVLLIPMTGPrgigirmtepIYLSPSFDNvls 125
Cdd:COG0144   172 NEPPPL--DLRVNTLKASRE--------ELLARLAEEGIEAEPTPLSPDGLRLEGPGP----------VTALPGFRE--- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 126 GYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFD 205
Cdd:COG0144   229 GLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVVAD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 206 ATKALKlevmdgvdgappFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVY 282
Cdd:COG0144   309 ARELLE------------WLPGKFDRVLLDAPCSGTGtlrRHPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVY 376

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046865904 283 STCTVTLAENEEQVAWALRTFPCLQLQPQEPQIGGEGMLGAG 324
Cdd:COG0144   377 STCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLALTDGG 418
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 46-324 1.98e-74

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 237.98  E-value: 1.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  46 LSHPPLftTVRVNTHLGSVEhvrgllleELQKQFGGSSIPVLQHPALPDVLLIPMTGPrgigirmtepIYLSPSFDNvls 125
Cdd:COG0144   172 NEPPPL--DLRVNTLKASRE--------ELLARLAEEGIEAEPTPLSPDGLRLEGPGP----------VTALPGFRE--- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 126 GYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFD 205
Cdd:COG0144   229 GLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVVAD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 206 ATKALKlevmdgvdgappFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVY 282
Cdd:COG0144   309 ARELLE------------WLPGKFDRVLLDAPCSGTGtlrRHPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVY 376

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046865904 283 STCTVTLAENEEQVAWALRTFPCLQLQPQEPQIGGEGMLGAG 324
Cdd:COG0144   377 STCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLALTDGG 418
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
34-304 1.75e-66

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 217.35  E-value: 1.75e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  34 EAERNFETLLLRlshPPlfTTVRVNTHLGSVEHvrglLLEELQKQFggssIPVLQHPALPDVLLIPmtgpRGigirmteP 113
Cdd:PRK14902  165 KAEKILESLNEP---PK--ASIRVNTLKISVEE----LIEKLEEEG----YEVEESLLSPEALVIE----KG-------N 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 114 IYLSPSFDNvlsGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASL 193
Cdd:PRK14902  221 IAGTDLFKD---GLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKR 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 194 LGLHSIRAFCFDATKalklevmdgvdgAPPFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVA 270
Cdd:PRK14902  298 LGLTNIETKALDARK------------VHEKFAEKFDKILVDAPCSGLGvirRKPDIKYNKTKEDIESLQEIQLEILESV 365

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1046865904 271 VRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFP 304
Cdd:PRK14902  366 AQYLKKGGILVYSTCTIEKEENEEVIEAFLEEHP 399
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 139-333 4.32e-53

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 174.92  E-value: 4.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 139 AHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKalklevmdgv 218
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQ---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 219 dgaPPFLP--ESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVYSTCTVTLAENE 293
Cdd:pfam01189  71 ---PDQWLggVLFDRILLDAPCSGTGvirRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKPGGVLVYSTCSVLPEENE 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1046865904 294 EQVAWALRTFPCLQLQPqepqIGGEGMLGAGLSLEQLKQL 333
Cdd:pfam01189 148 AVIEYFLQKHPDVELVP----TPLFEPVGLAIGEQPTLRL 183
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 124-377 2.26e-48

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 164.95  E-value: 2.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 124 LSGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFC 203
Cdd:TIGR00446  49 LFGYYYPQEASSMIPPIALEPREDERVLDMAAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVIN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 204 FDATKalklevmdgvdgAPPFLPEsFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVL 280
Cdd:TIGR00446 129 ADGRK------------FGAYLLK-FDAILLDAPCSGEGvirKDPSRKRNWSEEDIKYCSLLQKELIDAAIDALKPGGVL 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 281 VYSTCTVTLAENEEQVAWALRTFPCLQLqpqEPQIGGEgMLGAGLSLEQLKQLQRFDPcvvplesmdtnslgdarredvi 360
Cdd:TIGR00446 196 VYSTCSLEVEENEEVIDYILRKRPDVVE---EIIKGDE-FFGINIGKGEVKGALRVFP---------------------- 249

                         250
                  ....*....|....*..
gi 1046865904 361 wlANKDCIGFFIAKFLK 377
Cdd:TIGR00446 250 --QNYDCEGFFVAKLRK 264
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-283 1.49e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 149 KILDLCAAPGGKTTHIAAlmRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKAlklevmdgvdgaPPFLPES 228
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL------------PPEADES 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046865904 229 FDRILLDAPCSGLgqrpnmactwtlkevtsyQPLQRKLLNVAVRLLKPGGVLVYS 283
Cdd:cd02440    67 FDVIISDPPLHHL------------------VEDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 46-324 1.98e-74

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 237.98  E-value: 1.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  46 LSHPPLftTVRVNTHLGSVEhvrgllleELQKQFGGSSIPVLQHPALPDVLLIPMTGPrgigirmtepIYLSPSFDNvls 125
Cdd:COG0144   172 NEPPPL--DLRVNTLKASRE--------ELLARLAEEGIEAEPTPLSPDGLRLEGPGP----------VTALPGFRE--- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 126 GYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFD 205
Cdd:COG0144   229 GLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVVAD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 206 ATKALKlevmdgvdgappFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVY 282
Cdd:COG0144   309 ARELLE------------WLPGKFDRVLLDAPCSGTGtlrRHPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVY 376

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046865904 283 STCTVTLAENEEQVAWALRTFPCLQLQPQEPQIGGEGMLGAG 324
Cdd:COG0144   377 STCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLALTDGG 418
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
34-304 1.75e-66

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 217.35  E-value: 1.75e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  34 EAERNFETLLLRlshPPlfTTVRVNTHLGSVEHvrglLLEELQKQFggssIPVLQHPALPDVLLIPmtgpRGigirmteP 113
Cdd:PRK14902  165 KAEKILESLNEP---PK--ASIRVNTLKISVEE----LIEKLEEEG----YEVEESLLSPEALVIE----KG-------N 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 114 IYLSPSFDNvlsGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASL 193
Cdd:PRK14902  221 IAGTDLFKD---GLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKR 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 194 LGLHSIRAFCFDATKalklevmdgvdgAPPFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVA 270
Cdd:PRK14902  298 LGLTNIETKALDARK------------VHEKFAEKFDKILVDAPCSGLGvirRKPDIKYNKTKEDIESLQEIQLEILESV 365

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1046865904 271 VRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFP 304
Cdd:PRK14902  366 AQYLKKGGILVYSTCTIEKEENEEVIEAFLEEHP 399
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 72-326 3.89e-61

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 203.24  E-value: 3.89e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  72 LEELQKQFGGSSIPVLQHPALPDVLLIpmTGPRGigirmtePIYLSPSFDNvlsGYIFLQNLPSTVVAHVLDPQPGEKIL 151
Cdd:PRK14901  190 LEEVQAALAEAGITATPIPGLPQGLRL--TGNPG-------SIRQLPGYEE---GWWTVQDRSAQLVAPLLDPQPGEVIL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 152 DLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKALklevmdgvdGAPPFLPESFDR 231
Cdd:PRK14901  258 DACAAPGGKTTHIAELMGDQGEIWAVDRSASRLKKLQENAQRLGLKSIKILAADSRNLL---------ELKPQWRGYFDR 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 232 ILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFPCLQL 308
Cdd:PRK14901  329 ILLDAPCSGLGtlhRHPDARWRQTPEKIQELAPLQAELLESLAPLLKPGGTLVYATCTLHPAENEAQIEQFLARHPDWKL 408

                         250       260
                  ....*....|....*....|...
gi 1046865904 309 QPQEPQI-----GGEGMLGAGLS 326
Cdd:PRK14901  409 EPPKQKIwphrqDGDGFFMAVLR 431
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 139-333 4.32e-53

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 174.92  E-value: 4.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 139 AHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKalklevmdgv 218
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQ---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 219 dgaPPFLP--ESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVYSTCTVTLAENE 293
Cdd:pfam01189  71 ---PDQWLggVLFDRILLDAPCSGTGvirRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKPGGVLVYSTCSVLPEENE 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1046865904 294 EQVAWALRTFPCLQLQPqepqIGGEGMLGAGLSLEQLKQL 333
Cdd:pfam01189 148 AVIEYFLQKHPDVELVP----TPLFEPVGLAIGEQPTLRL 183
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 124-377 2.26e-48

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 164.95  E-value: 2.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 124 LSGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFC 203
Cdd:TIGR00446  49 LFGYYYPQEASSMIPPIALEPREDERVLDMAAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVIN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 204 FDATKalklevmdgvdgAPPFLPEsFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVL 280
Cdd:TIGR00446 129 ADGRK------------FGAYLLK-FDAILLDAPCSGEGvirKDPSRKRNWSEEDIKYCSLLQKELIDAAIDALKPGGVL 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 281 VYSTCTVTLAENEEQVAWALRTFPCLQLqpqEPQIGGEgMLGAGLSLEQLKQLQRFDPcvvplesmdtnslgdarredvi 360
Cdd:TIGR00446 196 VYSTCSLEVEENEEVIDYILRKRPDVVE---EIIKGDE-FFGINIGKGEVKGALRVFP---------------------- 249

                         250
                  ....*....|....*..
gi 1046865904 361 wlANKDCIGFFIAKFLK 377
Cdd:TIGR00446 250 --QNYDCEGFFVAKLRK 264
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 114-310 2.74e-45

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 161.77  E-value: 2.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 114 IYLSPSFDN----VLSGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQ 189
Cdd:PRK14904  214 FFLSKDFSLfepfLKLGLVSVQNPTQALACLLLNPQPGSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRS 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 190 NASLLGLHSIRAFCFDATKalklevmdgvdgappFLPE-SFDRILLDAPCSG---LGQRPNMACTWTLKEVTSYQPLQRK 265
Cdd:PRK14904  294 HASALGITIIETIEGDARS---------------FSPEeQPDAILLDAPCTGtgvLGRRAELRWKLTPEKLAELVGLQAE 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046865904 266 LLNVAVRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFPCLQLQP 310
Cdd:PRK14904  359 LLDHAASLLKPGGVLVYATCSIEPEENELQIEAFLQRHPEFSAEP 403
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 33-317 9.56e-44

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 156.95  E-value: 9.56e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  33 QEAERNFETLLLR--LSHPPLftTVRVNTHLGSVEHVRGLLLEElqkqfGGSSIPVLQHPALPDvLLIPMtgprgigirm 110
Cdd:TIGR00563 146 QKAYPGQWQSICEanNQRPPM--WLRINRTKHSRDEWLALLAEA-----GMKGFPHDLAPDAVR-LETPA---------- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 111 tePIYLSPSFDNvlsGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRdQGEVIALDKILTKVTKLKQN 190
Cdd:TIGR00563 208 --AVHALPGFEE---GWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAP-QAQVVALDIHEHRLKRVYEN 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 191 ASLLGLhsirafcfdatkALKLEVMDGVDGAPPFLPES--FDRILLDAPCSGLG---QRPNMacTWTLKEVTSYQ--PLQ 263
Cdd:TIGR00563 282 LKRLGL------------TIKAETKDGDGRGPSQWAENeqFDRILLDAPCSATGvirRHPDI--KWLRKPRDIAElaELQ 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046865904 264 RKLLNVAVRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFPCLQL----QPQEPQIGG 317
Cdd:TIGR00563 348 SEILDAIWPLLKTGGTLVYATCSVLPEENSEQIKAFLQEHPDFPFektgTPEQVRDGG 405
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
47-311 7.11e-43

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 154.58  E-value: 7.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  47 SHPPLftTVRVNTHLGSVEHVRGLLleelqKQFGGSSIPvlqHPALPDvllipmtgprgiGIRMTEPI---YLsPSFDnv 123
Cdd:PRK10901  168 QRPPM--WLRVNRRHHSRDAYLALL-----AEAGIEAFP---HAVGPD------------AIRLETPVpvhQL-PGFA-- 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 124 lSGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALmRDQGEVIALDKILTKVTKLKQNASLLGLHSiRAFC 203
Cdd:PRK10901  223 -EGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILEL-APQAQVVALDIDAQRLERVRENLQRLGLKA-TVIV 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 204 FDATKALKLevmdgVDGAPpflpesFDRILLDAPCSGLG-----------QRPNmactwtlkEVTSYQPLQRKLLNVAVR 272
Cdd:PRK10901  300 GDARDPAQW-----WDGQP------FDRILLDAPCSATGvirrhpdikwlRRPE--------DIAALAALQSEILDALWP 360

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1046865904 273 LLKPGGVLVYSTCTVTLAENEEQVAWALRTFPCLQLQPQ 311
Cdd:PRK10901  361 LLKPGGTLLYATCSILPEENEQQIKAFLARHPDAELLDT 399
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 43-302 6.32e-34

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 130.38  E-value: 6.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  43 LLRLSHPPLFTTVRVNTHLGSVEHVRGLLLEELQKQFGGSSIPVlqhpalpdVLLIpmtgpRGIGIRMTEpiylspsFDN 122
Cdd:PRK14903  154 IMEWNQEPLPTMLRVNSLAITREEVIKILAEEGTEAVPGKHSPF--------SLIV-----RKLGVNMND-------SRV 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 123 VLSGYIFLQNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAF 202
Cdd:PRK14903  214 IKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKRLKLSSIEIK 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 203 CFDATKALKlevmdgvdgappFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGV 279
Cdd:PRK14903  294 IADAERLTE------------YVQDTFDRILVDAPCTSLGtarNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLLEKGGI 361

                         250       260
                  ....*....|....*....|....
gi 1046865904 280 LVYSTCTVTLAENEEQV-AWALRT 302
Cdd:PRK14903  362 LLYSTCTVTKEENTEVVkRFVYEQ 385
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 124-304 1.64e-32

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 127.33  E-value: 1.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 124 LSGYIFLQN----LPstVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSI 199
Cdd:PRK11933   89 LSGLFYIQEassmLP--VAALFADDNAPQRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNV 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 200 RAFCFDATkalklevmdgVDGAppFLPESFDRILLDAPCSGLG---QRPNMACTWTLKEVTSYQPLQRKLLNVAVRLLKP 276
Cdd:PRK11933  167 ALTHFDGR----------VFGA--ALPETFDAILLDAPCSGEGtvrKDPDALKNWSPESNLEIAATQRELIESAFHALKP 234

                         170       180
                  ....*....|....*....|....*...
gi 1046865904 277 GGVLVYSTCTVTLAENEEQVAWALRTFP 304
Cdd:PRK11933  235 GGTLVYSTCTLNREENQAVCLWLKETYP 262
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-283 1.49e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 149 KILDLCAAPGGKTTHIAAlmRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKAlklevmdgvdgaPPFLPES 228
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL------------PPEADES 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046865904 229 FDRILLDAPCSGLgqrpnmactwtlkevtsyQPLQRKLLNVAVRLLKPGGVLVYS 283
Cdd:cd02440    67 FDVIISDPPLHHL------------------VEDLARFLEEARRLLKPGGVLVLT 103
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 120-281 4.09e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.61  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 120 FDNVLSGYIFLQNLpstvvAHVLDPQPGEKILDLCAAPGgktTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHsI 199
Cdd:COG2226     1 FDRVAARYDGREAL-----LAALGLRPGARVLDLGCGTG---RLALALAERGARVTGVDISPEMLELARERAAEAGLN-V 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 200 RAFCFDATkalklevmdgvdgAPPFLPESFDRILldapcsglgqrpnmaCTWTLKEVTSyqplQRKLLNVAVRLLKPGGV 279
Cdd:COG2226    72 EFVVGDAE-------------DLPFPDGSFDLVI---------------SSFVLHHLPD----PERALAEIARVLKPGGR 119


                  ..
gi 1046865904 280 LV 281
Cdd:COG2226   120 LV 121
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 146-320 1.85e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.41  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 146 PGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKALKLevmdgvdgappFL 225
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPEL-----------LE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 226 PESFDRILLDapcsglgqrpnmactwtlkEVTSYQPLQRKLLNVAVRLLKPGGVLVYSTCtVTLAENEEQVawaLRTFPC 305
Cdd:pfam13847  72 DDKFDVVISN-------------------CVLNHIPDPDKVLQEILRVLKPGGRLIISDP-DSLAELPAHV---KEDSTY 128

                         170
                  ....*....|....*
gi 1046865904 306 LQLQPQEPQIGGEGM 320
Cdd:pfam13847 129 YAGCVGGAILKKKLY 143
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 146-282 1.64e-05

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 46.39  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 146 PGEKILDLCAAPGGKTTHIAAlmRDQGEVIALDKILTKVTKLKQNASLLGL-HSIRAFCFDATKalklevmdgvdgAPPF 224
Cdd:COG2520   180 PGERVLDMFAGVGPFSIPIAK--RSGAKVVAIDINPDAVEYLKENIRLNKVeDRVTPILGDARE------------VAPE 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046865904 225 LPESFDRILLDAPCSGLgqrpnmactwtlkevtsyqplqrKLLNVAVRLLKPGGVLVY 282
Cdd:COG2520   246 LEGKADRIIMNLPHSAD-----------------------EFLDAALRALKPGGVIHY 280
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 146-281 5.39e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 43.35  E-value: 5.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 146 PGEKILDLCAAPGGKTThiAALMRDQGEVIALDKILTKVTKLKQNAsllGLHSIRAFCFDATKALKLEvmdgvdgapPFL 225
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQ--VALQRGAGKVVGVDLGPMQLWKPRNDP---GVTFIQGDIRDPETLDLLE---------ELL 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046865904 226 PESFDRILLDApcsglgqRPNMACTWTLKEVTSYQpLQRKLLNVAVRLLKPGGVLV 281
Cdd:pfam01728  87 GRKVDLVLSDG-------SPFISGNKVLDHLRSLD-LVKAALEVALELLRKGGNFV 134
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 145-284 6.75e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 43.01  E-value: 6.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 145 QPGEKILDLCAapGGKTTHIAALMRDqGEVIALDkILTK-VTKLKQNASLLGLHSIRAFCFDATKalklevmdgvdgaPP 223
Cdd:COG1041    25 KEGDTVLDPFC--GTGTILIEAGLLG-RRVIGSD-IDPKmVEGARENLEHYGYEDADVIRGDARD-------------LP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046865904 224 FLPESFDRILLDAPcsgLGQRPnmacTWTLKEVTSyqpLQRKLLNVAVRLLKPGGVLVYST 284
Cdd:COG1041    88 LADESVDAIVTDPP---YGRSS----KISGEELLE---LYEKALEEAARVLKPGGRVVIVT 138
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 147-301 6.90e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 44.40  E-value: 6.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 147 GEKILDLCAAPGGKTthIAALMRDQGEVIALDKILTKVTKLKQNASLLGL----HSIRAFCFDATKALKLEvmdgvdgap 222
Cdd:COG1092   217 GKRVLNLFSYTGGFS--VHAAAGGAKSVTSVDLSATALEWAKENAALNGLddrhEFVQADAFDWLRELARE--------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 223 pflPESFDRILLDAPC-----SGL--GQRpnmactwtlkevtSYqplqRKLLNVAVRLLKPGGVLVYSTCT--VTLAENE 293
Cdd:COG1092   286 ---GERFDLIILDPPAfakskKDLfdAQR-------------DY----KDLNRLALKLLAPGGILVTSSCSrhFSLDLFL 345


                  ....*...
gi 1046865904 294 EQVAWALR 301
Cdd:COG1092   346 EILARAAR 353
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 150-278 7.62e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.40  E-value: 7.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 150 ILDLCAAPGGKTTHIAAlmRDQGEVIALDKILTKVTKLKQNASLLGLHsIRAFCFDATkalklevmdgvdgAPPFLPESF 229
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR--RGGARVTGVDLSPEMLERARERAAEAGLN-VEFVQGDAE-------------DLPFPDGSF 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1046865904 230 DRILldapcsglgqrpnmaCTWTLKEVTsyQPLQRKLLNVAVRLLKPGG 278
Cdd:pfam13649  65 DLVV---------------SSGVLHHLP--DPDLEAALREIARVLKPGG 96
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 56-286 1.70e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 42.84  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904  56 RVNTHLGSVEHvrglllEEL-QKQFG-------GSSIPVLQhPALPDvllIPMTGPRGigirmTEPIYlsPSfDnvlSGY 127
Cdd:COG2519    24 KFHTHKGIIDH------DDLiGKPEGsvvttskGKEFLVLR-PTLYD---YVLSMKRG-----TQIIY--PK-D---AGY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 128 IflqnlpstvvAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHsirafcfdat 207
Cdd:COG2519    83 I----------IARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLP---------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 208 KALKLEVMDGVDGAPPflpESFDRILLD--APcsglgqrpnmactWtlkevtsyqplqrKLLNVAVRLLKPGGVLV-YST 284
Cdd:COG2519   143 DNVELKLGDIREGIDE---GDVDAVFLDmpDP-------------W-------------EALEAVAKALKPGGVLVaYVP 193


                  ..
gi 1046865904 285 CT 286
Cdd:COG2519   194 TV 195
PRK14967 PRK14967
putative methyltransferase; Provisional
 146-330 1.89e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 42.35  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 146 PGEKILDLCAAPGGKTTHIAALmrDQGEVIALDKILTKVTKLKQNASLLGLHsIRAFCFDATKALKLEVMDGVDGAPPFL 225
Cdd:PRK14967   36 PGRRVLDLCTGSGALAVAAAAA--GAGSVTAVDISRRAVRSARLNALLAGVD-VDVRRGDWARAVEFRPFDVVVSNPPYV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 226 PESFDRilldAPCSGLGQrpnmacTWtlkevtSYQPLQRKLLN----VAVRLLKPGGVL--VYSTC---TVTLAENEEQ- 295
Cdd:PRK14967  113 PAPPDA----PPSRGPAR------AW------DAGPDGRAVLDrlcdAAPALLAPGGSLllVQSELsgvERTLTRLSEAg 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1046865904 296 -----VAWALRTF-PClqLQPQEPQIGGEGMLGAGLSLEQL 330
Cdd:PRK14967  177 ldaevVASQWIPFgPV--LRARAAWLERRGLLPPGQREEEL 215
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 146-284 1.91e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.77  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 146 PGEKILDLCAAPGgkttHIAALMRDQG-EVIALDKILTKVTKLKQNASLLGlhsIRAFCFDATKAlklevmdgvdgapPF 224
Cdd:COG2227    24 AGGRVLDVGCGTG----RLALALARRGaDVTGVDISPEALEIARERAAELN---VDFVQGDLEDL-------------PL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 225 LPESFDRILldapCSglgqrpnmactwtlkEVTSYQPLQRKLLNVAVRLLKPGGVLVYST 284
Cdd:COG2227    84 EDGSFDLVI----CS---------------EVLEHLPDPAALLRELARLLKPGGLLLLST 124
PRK08317 PRK08317
hypothetical protein; Provisional
 142-281 1.96e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.62  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 142 LDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKiltkvtklkqNASLLGLHSIRAfcfdATKALKLEVMDGVDGA 221
Cdd:PRK08317   15 LAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDR----------SEAMLALAKERA----AGLGPNVEFVRGDADG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 222 PPFLPESFDRILLDapcsglgqrpnmactwtlkEVTSYQPLQRKLLNVAVRLLKPGGVLV 281
Cdd:PRK08317   81 LPFPDGSFDAVRSD-------------------RVLQHLEDPARALAEIARVLRPGGRVV 121
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 138-283 3.47e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.44  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 138 VAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQgeVIALDKILTKVTKLKQNASLLGLHSIRafcfdatkalkLEVMDg 217
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGR--VIGIDLSPEAIALARARAAKAGLGNVE-----------FLVAD- 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046865904 218 VDGAPPFLPESFDRILLdapcsglgqrpNMACTWTLKEVtsyqplQRKLLNVAVRLLKPGGVLVYS 283
Cdd:COG0500    84 LAELDPLPAESFDLVVA-----------FGVLHHLPPEE------REALLRELARALKPGGVLLLS 132
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
142-240 6.68e-04

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 41.68  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 142 LDPQPGEKILDLCAAPGGKTTHIAalmRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKALKLEvmdgvdga 221
Cdd:PRK13168  293 LDPQPGDRVLDLFCGLGNFTLPLA---RQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANLEEDFTDQ-------- 361

                          90
                  ....*....|....*....
gi 1046865904 222 pPFLPESFDRILLDAPCSG 240
Cdd:PRK13168  362 -PWALGGFDKVLLDPPRAG 379
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
144-281 1.38e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 39.73  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046865904 144 PQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLKQNASLLGLHSIRAFCFDATKAlklevmdgvdgapP 223
Cdd:pfam01209  40 VKRGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEEL-------------P 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046865904 224 FLPESFDRILLdapcsGLGqrpnmactwtLKEVTSYQplqrKLLNVAVRLLKPGGVLV 281
Cdd:pfam01209 107 FEDDSFDIVTI-----SFG----------LRNFPDYL----KVLKEAFRVLKPGGRVV 145
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 146-178 1.75e-03

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 39.28  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1046865904 146 PGEKILDLCAAPGGKTTHIAALMRDQGEVIALD 178
Cdd:COG0293    50 PGMRVVDLGAAPGGWSQVAAKRVGGKGRVIALD 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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