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Conserved domains on  [gi|1046858455|ref|XP_017454618|]
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COMM domain-containing protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 1-119 7.47e-66

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04749:

Pssm-ID: 471425 [Multi-domain]  Cd Length: 174  Bit Score: 196.96  E-value: 7.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858455   1 MDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKTKIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIE 80
Cdd:cd04749    56 MDINQLEAFLTAQTKKQGGITSLQAAVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVE 135

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046858455  81 LEFGRSGRESEFLCLEFDEAKVKQILKKLSEVEESISGL 119
Cdd:cd04749   136 LELGKTGQESEFVCLEFDEAKVNRVLKQLAEIQESLDAL 174
 
Name Accession Description Interval E-value
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 1-119 7.47e-66

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 196.96  E-value: 7.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858455   1 MDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKTKIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIE 80
Cdd:cd04749    56 MDINQLEAFLTAQTKKQGGITSLQAAVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVE 135

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046858455  81 LEFGRSGRESEFLCLEFDEAKVKQILKKLSEVEESISGL 119
Cdd:cd04749   136 LELGKTGQESEFVCLEFDEAKVNRVLKQLAEIQESLDAL 174
COMMD1_N pfam17221
COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.
 1-41 1.31e-24

COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.


Pssm-ID: 465387  Cd Length: 102  Bit Score: 89.73  E-value: 1.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046858455   1 MDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKTKIRE 41
Cdd:pfam17221  62 MDLNQLEAFLTAQTKKQGGLSAEQAAAIAKFWKSHKTKIRE 102
 
Name Accession Description Interval E-value
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 1-119 7.47e-66

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 196.96  E-value: 7.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858455   1 MDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKTKIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIE 80
Cdd:cd04749    56 MDINQLEAFLTAQTKKQGGITSLQAAVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVE 135

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046858455  81 LEFGRSGRESEFLCLEFDEAKVKQILKKLSEVEESISGL 119
Cdd:cd04749   136 LELGKTGQESEFVCLEFDEAKVNRVLKQLAEIQESLDAL 174
COMMD1_N pfam17221
COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.
 1-41 1.31e-24

COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.


Pssm-ID: 465387  Cd Length: 102  Bit Score: 89.73  E-value: 1.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046858455   1 MDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKTKIRE 41
Cdd:pfam17221  62 MDLNQLEAFLTAQTKKQGGLSAEQAAAIAKFWKSHKTKIRE 102
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 31-116 8.89e-19

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 74.65  E-value: 8.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858455  31 FWKSHKTKIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIELEFG-RSGRESEFLCLEFDEAKVKQILKKL 109
Cdd:cd04748     1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQvGDNNSSEKICFEMTKEELQNFLNKL 80


                  ....*..
gi 1046858455 110 SEVEESI 116
Cdd:cd04748    81 KKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 49-112 4.69e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 51.40  E-value: 4.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046858455  49 WDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIELEFGRSGRESEFLCLEFDEAKVKQILKKLSEV 112
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 16-119 2.16e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 35.87  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858455  16 KQGGITSEQAAVISKFWKSHKTKIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIELEF-GRSGRESEFLC 94
Cdd:cd04752    70 QQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVrNADTGEITPHP 149

                          90       100
                  ....*....|....*....|....*
gi 1046858455  95 LEFDEAKVKQILKKLSEVEESISGL 119
Cdd:cd04752   150 FSVSADKFRVLLAELKQAQTLMETL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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