NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039797267|ref|XP_017173972|]
View 

teneurin-1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ten_N super family cl24184
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
23-317 1.24e-78

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


The actual alignment was detected with superfamily member pfam06484:

Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 265.69  E-value: 1.24e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484   13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484   93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484  172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484  252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039797267  282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484  332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1196-1527 3.17e-38

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 147.29  E-value: 3.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1269
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1270 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1347
Cdd:cd14953    104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1348 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1424
Cdd:cd14953    170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1425 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1504
Cdd:cd14953    236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
                          330       340
                   ....*....|....*....|...
gi 1039797267 1505 SLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14953    301 GVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2647-2724 1.52e-35

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


:

Pssm-ID: 464783  Cd Length: 78  Bit Score: 130.42  E-value: 1.52e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2647 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2724
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1490-2423 9.41e-31

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


:

Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 133.34  E-value: 9.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1490 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1569
Cdd:COG3209    119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1570 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1649
Cdd:COG3209    199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1650 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1726
Cdd:COG3209    279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1727 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1806
Cdd:COG3209    359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1807 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1886
Cdd:COG3209    439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1887 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1966
Cdd:COG3209    519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1967 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2046
Cdd:COG3209    599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2047 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2126
Cdd:COG3209    677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2127 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2201
Cdd:COG3209    757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2202 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2281
Cdd:COG3209    836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2282 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2361
Cdd:COG3209    905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2362 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2423
Cdd:COG3209    965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
802-827 2.43e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


:

Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 2.43e-09
                           10        20
                   ....*....|....*....|....*.
gi 1039797267  802 CGDNLDNDGDGLTDCVDPDCCQQSNC 827
Cdd:NF033662     7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
DUF5885 super family cl44670
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
529-720 3.65e-06

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


The actual alignment was detected with superfamily member pfam19232:

Pssm-ID: 437064  Cd Length: 265  Bit Score: 51.16  E-value: 3.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  529 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 577
Cdd:pfam19232   10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  578 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 624
Cdd:pfam19232   84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  625 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 676
Cdd:pfam19232  164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1039797267  677 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 720
Cdd:pfam19232  238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
DSL super family cl19567
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
711-754 2.20e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


The actual alignment was detected with superfamily member pfam01414:

Pssm-ID: 473190  Cd Length: 46  Bit Score: 41.07  E-value: 2.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039797267  711 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 754
Cdd:pfam01414    1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
23-317 1.24e-78

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 265.69  E-value: 1.24e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484   13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484   93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484  172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484  252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039797267  282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484  332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1196-1527 3.17e-38

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 147.29  E-value: 3.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1269
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1270 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1347
Cdd:cd14953    104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1348 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1424
Cdd:cd14953    170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1425 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1504
Cdd:cd14953    236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
                          330       340
                   ....*....|....*....|...
gi 1039797267 1505 SLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14953    301 GVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2647-2724 1.52e-35

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 130.42  E-value: 1.52e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2647 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2724
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1490-2423 9.41e-31

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 133.34  E-value: 9.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1490 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1569
Cdd:COG3209    119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1570 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1649
Cdd:COG3209    199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1650 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1726
Cdd:COG3209    279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1727 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1806
Cdd:COG3209    359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1807 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1886
Cdd:COG3209    439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1887 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1966
Cdd:COG3209    519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1967 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2046
Cdd:COG3209    599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2047 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2126
Cdd:COG3209    677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2127 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2201
Cdd:COG3209    757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2202 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2281
Cdd:COG3209    836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2282 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2361
Cdd:COG3209    905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2362 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2423
Cdd:COG3209    965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
802-827 2.43e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 2.43e-09
                           10        20
                   ....*....|....*....|....*.
gi 1039797267  802 CGDNLDNDGDGLTDCVDPDCCQQSNC 827
Cdd:NF033662     7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1196-1525 6.56e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 59.65  E-value: 6.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1273 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1350
Cdd:COG4257     86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1351 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1430
Cdd:COG4257    134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1431 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1510
Cdd:COG4257    187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
                          330
                   ....*....|....*
gi 1039797267 1511 DGTLYVADLGNVRIR 1525
Cdd:COG4257    241 DGRVWFAESGANRIV 255
DUF5885 pfam19232
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
529-720 3.65e-06

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


Pssm-ID: 437064  Cd Length: 265  Bit Score: 51.16  E-value: 3.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  529 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 577
Cdd:pfam19232   10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  578 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 624
Cdd:pfam19232   84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  625 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 676
Cdd:pfam19232  164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1039797267  677 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 720
Cdd:pfam19232  238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2345-2423 1.65e-05

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 45.18  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2345 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2418
Cdd:TIGR03696    1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67

                   ....*
gi 1039797267 2419 PVGKI 2423
Cdd:TIGR03696   68 PVNWV 72
RHS_core NF041261
RHS element core protein;
1574-1689 3.44e-05

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 49.62  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1574 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1653
Cdd:NF041261   602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1039797267 1654 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1689
Cdd:NF041261   659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
711-754 2.20e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 41.07  E-value: 2.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039797267  711 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 754
Cdd:pfam01414    1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
651-794 3.00e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.51  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  651 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 724
Cdd:NF041328    18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039797267  725 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 794
Cdd:NF041328    82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
23-317 1.24e-78

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 265.69  E-value: 1.24e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484   13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267   92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484   93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484  172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484  252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039797267  282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484  332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1196-1527 3.17e-38

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 147.29  E-value: 3.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1269
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1270 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1347
Cdd:cd14953    104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1348 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1424
Cdd:cd14953    170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1425 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1504
Cdd:cd14953    236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
                          330       340
                   ....*....|....*....|...
gi 1039797267 1505 SLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14953    301 GVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2647-2724 1.52e-35

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 130.42  E-value: 1.52e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2647 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2724
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1247-1528 6.07e-34

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 134.58  E-value: 6.07e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1247 LAMDPmSESLYLSDTNTRKVYKL--KSLVETkdlsknfevVAGTGDQclpfdqshcG-DGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14953     28 VAVDA-AGNLYVADRGNHRIRKItpDGVVTT---------VAGTGTA---------GfADGGGAAAQFNTPSGVAVDAAG 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1324 FIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDSGMdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISEN 1399
Cdd:cd14953     89 NLYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPD 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1400 RRVRIIAGRPihcqVPGidhFLVSKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDCdc 1479
Cdd:cd14953    162 GVVTTVAGTG----GAG---YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTAG-- 229
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1039797267 1480 kidpncdcFSGDGGyAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTIS 1528
Cdd:cd14953    230 --------FSGDGG-ATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1490-2423 9.41e-31

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 133.34  E-value: 9.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1490 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1569
Cdd:COG3209    119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1570 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1649
Cdd:COG3209    199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1650 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1726
Cdd:COG3209    279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1727 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1806
Cdd:COG3209    359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1807 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1886
Cdd:COG3209    439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1887 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1966
Cdd:COG3209    519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1967 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2046
Cdd:COG3209    599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2047 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2126
Cdd:COG3209    677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2127 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2201
Cdd:COG3209    757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2202 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2281
Cdd:COG3209    836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2282 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2361
Cdd:COG3209    905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 2362 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2423
Cdd:COG3209    965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1284-1528 9.65e-30

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 122.64  E-value: 9.65e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1284 VVAGTGDqclpfdqSHCGDGGKASeASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDS 1361
Cdd:cd14953      3 TVAGSGT-------AGFSGGGGTA-ARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAG----TGTAGFADGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1362 GmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRpihcqvpGIDHFLVSKVAIHSTLESARAISV 1439
Cdd:cd14953     71 G---AAAQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAGT-------GTAGFSDDGGATAAQFNYPTGVAV 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1440 SHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADL 1519
Cdd:cd14953    140 DAAGNLYVADT---GNHRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLYVADR 205

                   ....*....
gi 1039797267 1520 GNVRIRTIS 1528
Cdd:cd14953    206 GNHRIRKIT 214
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1190-1527 4.17e-22

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 98.54  E-value: 4.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1190 NNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1267
Cdd:cd05819      4 PGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQ 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1268 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcGDGGkaseasLNSPRGITVDRHGFIYFVDgTM---IRRIDENAVITT 1344
Cdd:cd05819     80 KF-------DPDGNFLASFGGSGD---------GDGE------FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLT 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1345 VIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLDnnivlqiSENRRVRIIA--GRPIhcqvpgidhFLV 1422
Cdd:cd05819    137 TFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFDpdGNFL---------TTF 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1423 -SKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQqvttngeisiiagaptdcdcKIDPNCDCFSGDGGYA-KDAKM 1500
Cdd:cd05819    186 gSTGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQ--------------------VFDPDGAGFGGNGNFLgSDGQF 242
                          330       340
                   ....*....|....*....|....*..
gi 1039797267 1501 KAPSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd05819    243 NRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1311-1535 1.63e-18

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 88.14  E-value: 1.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1311 LNSPRGITVDRHGFIYFVDGTM--IRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVL 1388
Cdd:cd05819      7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFGSGDGQ--------------FNEPAGVAVDS-DGNLYVA 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1389 DnnivlqiSENRRVRII--AGRPI-HCQVPGIDhflvskvaiHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNG 1465
Cdd:cd05819     72 D-------TGNHRIQKFdpDGNFLaSFGGSGDG---------DGEFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPDG 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1466 EISIIAGAPTDCDCK--------IDPN-----CDC-------FSGDGGY--------AKDAKMKAPSSLAVSPDGTLYVA 1517
Cdd:cd05819    133 EFLTTFGSGGSGPGQfngptgvaVDSDgniyvADTgnhriqvFDPDGNFlttfgstgTGPGQFNYPTGIAVDSDGNIYVA 212
                          250
                   ....*....|....*...
gi 1039797267 1518 DLGNVRIRTISKNQAHLN 1535
Cdd:cd05819    213 DSGNNRVQVFDPDGAGFG 230
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1166-1396 1.31e-15

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 80.65  E-value: 1.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1166 VIATIMGNGHQRSVActncNGPAHNNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNsvsilelrnrdtrhstspah 1243
Cdd:cd14953    163 VVTTVAGTGGAGYAG----DGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGV-------------------- 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1244 kyylamdpmseslylsdtntrkvyklkslVETkdlsknfevVAGTGDQclPFdqshcGDGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14953    219 -----------------------------VTT---------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAG 253
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 1324 FIYFVD---GTmIRRIDENAVITTVIGSnglTSTQPLSCDSGmdiTQVRLEWPTDLAVNPmDNSLYVLD--NNIVLQI 1396
Cdd:cd14953    254 NLYVADsgnHR-IRKITPAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1303-1524 1.09e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 61.91  E-value: 1.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1303 GGKASEAslNSPRGITVDRHGFIYFVD--GTMIRRIDENaviTTVIGSNGLTSTQPLScdsgmditqvrLEWPTDLAVNP 1380
Cdd:cd14956    100 GSGPGQF--NAPRGVAVDADGNLYVADfgNQRIQKFDPD---GSFLRQWGGTGIEPGS-----------FNYPRGVAVDP 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1381 mDNSLYVLDnnivlqiSENRRVriiagrpihcQVPGIDHFLVSKVAIHST----LESARAISVSHSGLLFIAETDErkvN 1456
Cdd:cd14956    164 -DGTLYVAD-------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---N 222
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039797267 1457 RIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14956    223 RIQKFTADGTFLTSWGSPG-------------TGPG------QFKNPWGVVVDADGTVYVADSNNNRV 271
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
802-827 2.43e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 2.43e-09
                           10        20
                   ....*....|....*....|....*.
gi 1039797267  802 CGDNLDNDGDGLTDCVDPDCCQQSNC 827
Cdd:NF033662     7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1314-1524 2.49e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 60.76  E-value: 2.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1314 PRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLD-- 1389
Cdd:cd14956     62 PRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSSGSGPGQ--------------FNAPRGVAVDA-DGNLYVADfg 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1390 NNIVLQISENRR-VRIIAGRPIHcqvPGidHFLvskvaihstleSARAISVSHSGLLFIAETderKVNRIQQVTTNGEIS 1468
Cdd:cd14956    127 NQRIQKFDPDGSfLRQWGGTGIE---PG--SFN-----------YPRGVAVDPDGTLYVADT---YNDRIQVFDNDGAFL 187
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039797267 1469 IIAGAPtdcdckidpncdcFSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14956    188 RKWGGR-------------GTGPG------QFNYPYGIAIDPDGNVFVADFGNNRI 224
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1196-1525 6.56e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 59.65  E-value: 6.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1273 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1350
Cdd:COG4257     86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1351 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1430
Cdd:COG4257    134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1431 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1510
Cdd:COG4257    187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
                          330
                   ....*....|....*
gi 1039797267 1511 DGTLYVADLGNVRIR 1525
Cdd:COG4257    241 DGRVWFAESGANRIV 255
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1196-1524 2.08e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 57.60  E-value: 2.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDfnfvrrifpSGNSVsILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKLks 1271
Cdd:cd14952     12 PGGVAVDAAGNVYVAD---------SGNNR-VLKLAAGSTTQTVLPFTGLYqpqgVAVDA-AGTVYVTDFGNNRVLKL-- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1272 lvetkdlsknfevVAGTGDQC-LPFdqshcgdggkaseASLNSPRGITVDRHGFIYFVDGTmirridENAVITTVIGSNg 1350
Cdd:cd14952     79 -------------AAGSTTQTvLPF-------------TGLNDPTGVAVDAAGNVYVADTG------NNRVLKLAAGSN- 125
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1351 ltstqplscdsgmdiTQVRLEW-----PTDLAVNPMDNsLYVLDnnivlqiSENRRVRiiagrpihcqvpgidhflvsKV 1425
Cdd:cd14952    126 ---------------TQTVLPFtglsnPDGVAVDGAGN-VYVTD-------TGNNRVL--------------------KL 162
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1426 AIHST---------LESARAISVSHSGLLFIAETDErkvNRIQQVTtngeisiiAGAPTdcdckidPNCDCFSGdggyak 1496
Cdd:cd14952    163 AAGSTtqtvlpftgLNSPSGVAVDTAGNVYVTDHGN---NRVLKLA--------AGSTT-------PTVLPFTG------ 218
                          330       340
                   ....*....|....*....|....*...
gi 1039797267 1497 dakMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14952    219 ---LNGPLGVAVDAAGNVYVADRGNDRV 243
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1192-1405 3.67e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 57.30  E-value: 3.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1192 KLFAPVALASGPDGSVYVGDFnFVRRI--F-PSGNSVSILElRNRDTRHSTSPAHkyyLAMDpmSESLYLSDTNTRKVY- 1267
Cdd:cd14963     54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVIv 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1268 ------KLKSLVETKD-------------LSKNFEVVAGTGDQ-CLPFDQSHCG----DGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14963    127 fdlegkLLLEFGKPGSepgelsypngiavDEDGNIYVADSGNGrIQVFDKNGKFikelNGSPDGKSGFVNPRGIAVDPDG 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1324 FIYFVDgTMIRRI---DENAVITTVIGSNGLtstqplscdsgmDITQVRLewPTDLAVNPmDNSLYVLDnnivlqiSENR 1400
Cdd:cd14963    207 NLYVVD-NLSHRVyvfDEQGKELFTFGGRGK------------DDGQFNL--PNGLFIDD-DGRLYVTD-------RENN 263

                   ....*
gi 1039797267 1401 RVRII 1405
Cdd:cd14963    264 RVAVY 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1308-1527 5.76e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.48  E-value: 5.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1308 EASLNSPRGITVDRHGFIYFVDGT--MIRRID-ENAVITTVIGSNGLTStqplscdsgmditqvrlewPTDLAVNPmDNS 1384
Cdd:COG4257     55 LGGGSGPHGIAVDPDGNLWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGN 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1385 LYVLDNNivlqiseNRRVRII---AGRpihcqvpgidhflVSKVAIHSTLESARAISVSHSGLLFIAEtdeRKVNRIQQV 1461
Cdd:COG4257    115 LWFTDQG-------GNRIGRLdpaTGE-------------VTEFPLPTGGAGPYGIAVDPDGNLWVTD---FGANAIGRI 171
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039797267 1462 TT-NGEISIIAGaPTdcdckidpncdcfsgdggyakdaKMKAPSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:COG4257    172 DPdTGTLTEYAL-PT-----------------------PGAGPRGLAVDPDGNLWVADTGSGRIGRF 214
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
1311-1524 7.33e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 53.32  E-value: 7.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1311 LNSPRGITVDRHGFIYFVD--GTMIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPMDNsLYVL 1388
Cdd:cd14954     70 FDRPAGVAVNSRGRIIVADkdNHRIQVFDLNGRFLLKFGERGTKNGQ--------------FNYPWGVAVDSEGR-IYVS 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1389 DnnivlqiSENRRVRIIA--GRPIH---CQVPGIDHFlvskvaihstlESARAISVSHSGLLFIAETDErkvNRIQQVTT 1463
Cdd:cd14954    135 D-------TRNHRVQVFDsdGQFIRkfgFEGAGPGQL-----------DSPRGVAVNPDGNIVVSDFNN---HRLQVFDP 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1464 NGE-ISIIAGAPTDCDC-------KIDPN-----CDC-------FSGDGGYAK--------DAKMKAPSSLAVSPDGTLY 1515
Cdd:cd14954    194 DGQfLRFFGSEGSGNGQfkrprgvAVDDEgniivADSgnhrvqvFSPDGEFLCsfgtegngEGQFDRPSGVAVTPDGRIV 273

                   ....*....
gi 1039797267 1516 VADLGNVRI 1524
Cdd:cd14954    274 VVDRGNHRI 282
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
1304-1527 1.84e-06

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 52.58  E-value: 1.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1304 GKASEASLNSPRGITVDRHGFIYFVDgT---MIRRID-ENAVITTVIGsnglTSTQPLSCDSGMDITQVRLEWPTDLAVN 1379
Cdd:cd14951     11 GSFAEASFNEPQGLALLPGNILYVAD-TenhALRKIDlETGTVTTLAG----TGEQGRDGEGGGPGREQPLSSPWDVAWG 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1380 PMDNSLYV------------LDNNIVLQISENRRVRIIAGRPIH----CQVPGI----DHFL------------------ 1421
Cdd:cd14951     86 PEDDILYIamagthqiwaydLDTGTCRVFAGSGNEGNRNGPYPHeawfAQPSGLslagWGELfvadsessairavslkdg 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1422 VSKVAIHSTL---------------ESAR-----AISVSHSGLLFIAETDERKVNRIQQVTtnGEISIIAGaptdcdcki 1481
Cdd:cd14951    166 GVKTLVGGTRvgtglfdfgdrdgpgAEALlqhplGVAALPDGSVYVADTYNHKIKRVDPAT--GEVSTLAG--------- 234
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1039797267 1482 dpncdcfSGDGGYAKDAKMKA-PSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14951    235 -------TGKAGYKDLEAQFSePSGLVVDGDGRLYVADTNNHRIRRL 274
DUF5885 pfam19232
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
529-720 3.65e-06

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


Pssm-ID: 437064  Cd Length: 265  Bit Score: 51.16  E-value: 3.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  529 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 577
Cdd:pfam19232   10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  578 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 624
Cdd:pfam19232   84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  625 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 676
Cdd:pfam19232  164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1039797267  677 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 720
Cdd:pfam19232  238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1196-1524 5.60e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 50.66  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1196 PVALASGPDGSVYVGDfnfvrrifPSGNSVSILELRNRDT--------RHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1267
Cdd:cd14962     14 PYGVAADGRGRIYVAD--------TGRGAVFVFDLPNGKVfvignagpNRFVSPIG---VAIDA-NGNLYVSDAELGKVF 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1268 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcgdggkaseasLNSPRGITVDRHG-FIYFVD--GTMIRRIDENAVITT 1344
Cdd:cd14962     82 VF-------DRDGKFLRAIGAGAL-------------------FKRPTGIAVDPAGkRLYVVDtlAHKVKVFDLDGRLLF 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1345 VIGSNGltstqplscdSGmditQVRLEWPTDLAVNPMDNsLYVLDnnivlqiSENRRVRII--AGRPIHC-----QVPGi 1417
Cdd:cd14962    136 DIGKRG----------SG----PGEFNLPTDLAVDRDGN-LYVTD-------TMNFRVQIFdaDGKFLRSfgergDGPG- 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1418 dhflvskvaihsTLESARAISVSHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPtdcdckidpncdcFSGDGGYAkd 1497
Cdd:cd14962    193 ------------SFARPKGIAVDSEGNIYVVDA---AFDNVQIFNPEGELLLTVGGP-------------GSGPGEFY-- 242
                          330       340
                   ....*....|....*....|....*..
gi 1039797267 1498 akmkAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14962    243 ----LPSGIAIDKDDRIYVVDQFNRRI 265
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2345-2423 1.65e-05

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 45.18  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 2345 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2418
Cdd:TIGR03696    1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67

                   ....*
gi 1039797267 2419 PVGKI 2423
Cdd:TIGR03696   68 PVNWV 72
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
1851-1891 1.93e-05

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 43.73  E-value: 1.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039797267 1851 YSPSG-LVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYT 1891
Cdd:TIGR01643    1 YDAAGrLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1488-1530 3.12e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 48.68  E-value: 3.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039797267 1488 FSGDGGyaKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd14953     12 FSGGGG--TAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
RHS_core NF041261
RHS element core protein;
1574-1689 3.44e-05

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 49.62  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1574 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1653
Cdd:NF041261   602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1039797267 1654 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1689
Cdd:NF041261   659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1195-1471 4.46e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 47.71  E-value: 4.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1195 APVALASGPDGSVYVGDFNF--VRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257     60 GPHGIAVDPDGNLWFTDNGNnrIGRIDPKTGEITTFAL-------PGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL--- 128
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1273 vetkDLSKN-FEVVAGTGDQclpfdqshcgdggkaseaslNSPRGITVDRHGFIYFVD--GTMIRRID-ENAVITTVIGS 1348
Cdd:COG4257    129 ----DPATGeVTEFPLPTGG--------------------AGPYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALP 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1349 NGLTStqplscdsgmditqvrlewPTDLAVNPmDNSLYVLDnnivlqiSENRRVRII---AGRpihcqvpgidhflVSKV 1425
Cdd:COG4257    185 TPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGRFdpkTGT-------------VTEY 224
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1039797267 1426 AIHSTLESARAISVSHSGLLFIAETDerkVNRIQQVTTNGEISIIA 1471
Cdd:COG4257    225 PLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV 267
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1373-1535 2.07e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1373 PTDLAVNPMDNSLYVLDNNIVLQI--SENRRVRIIAGRPihcqvPGIDHFlvskvaihstlESARAISVSHSGLLFIAET 1450
Cdd:cd14956     15 PRGIAVDADDNVYVADARNGRIQVfdKDGTFLRRFGTTG-----DGPGQF-----------GRPRGLAVDKDGWLYVADY 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1451 DErkvNRIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGGYAkdakmkAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd14956     79 WG---DRIQVFTLTGELQTIGGSSG-------------SGPGQFN------APRGVAVDADGNLYVADFGNQRIQKFDPD 136

                   ....*
gi 1039797267 1531 QAHLN 1535
Cdd:cd14956    137 GSFLR 141
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
711-754 2.20e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 41.07  E-value: 2.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039797267  711 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 754
Cdd:pfam01414    1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
1199-1346 1.68e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.96  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1199 LASGPDGSVYVGDFNFVR------RIFPSGnSVSILElrnRDTRHSTSpahkyyLAMDPMSESLYLSDTNTRKVYKLkSL 1272
Cdd:COG3386     98 GVVDPDGRLYFTDMGEYLptgalyRVDPDG-SLRVLA---DGLTFPNG------IAFSPDGRTLYVADTGAGRIYRF-DL 166
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039797267 1273 VETKDLSkNFEVVAgtgdqclpfdQSHCGDGGkaseaslnsPRGITVDRHGFIY--FVDGTMIRRIDENAVITTVI 1346
Cdd:COG3386    167 DADGTLG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGELLGRI 222
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
665-689 1.82e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.82e-03
                           10        20
                   ....*....|....*....|....*
gi 1039797267  665 CSGHGTFLLDTGVCSCDPKWTGSDC 689
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
697-720 2.01e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|....*.
gi 1039797267  697 ECGSHGVCSR--GICQCEEGWVGPTC 720
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1496-1530 2.67e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.31  E-value: 2.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039797267 1496 KDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd05819      3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPD 37
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
651-794 3.00e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.51  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  651 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 724
Cdd:NF041328    18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039797267  725 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 794
Cdd:NF041328    82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
535-557 3.66e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.94  E-value: 3.66e-03
                           10        20
                   ....*....|....*....|....*
gi 1039797267  535 CNGNGECIS--GHCHCFPGFLGPDC 557
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
729-751 4.73e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 4.73e-03
                           10        20
                   ....*....|....*....|....*
gi 1039797267  729 CAEHGQCKD--GKCECSPGWEGDHC 751
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1191-1269 5.05e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.54  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267 1191 NKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPMSeSLYLSDTNTRKVYK 1268
Cdd:COG4257    185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPKTGTVTEYPL-------PGGGARPYGVAVDGDG-RVWFAESGANRIVR 256

                   .
gi 1039797267 1269 L 1269
Cdd:COG4257    257 F 257
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
595-731 7.06e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 39.77  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797267  595 CIDPTCFGHGTCIMGVCicvpgykGEICEEEDCLDPMCSSHGIC--VKGECHCSTGWGGVNCETPL--PIC------QEQ 664
Cdd:pfam01500    9 CGFPTCSTGGTCGSGCC-------QPCCCQSSCCRPSCCQTSCCqpTTFQSSCCRPTCQPCCQTSCcqPTCcqtsscQTG 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039797267  665 CSGHGTFLL-DTGVCSCDPKWTGSDCSTE-LCTMECGSHGVCSRGICQ--------CEEGWVGPTCEERSCHSHCAE 731
Cdd:pfam01500   82 CGGIGYGQEgSSGAVSSRTRWCRPDCRVEgTCLPPCCVVSCTPPTCCQlhhaqascCRPSYCGQSCCRPACCCQCSE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH