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Conserved domains on  [gi|1039753533|ref|XP_017172959|]
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zinc finger protein 811 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-30 1.57e-11

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 59.02  E-value: 1.57e-11
                          10        20
                  ....*....|....*....|....*....
gi 1039753533   2 EEWALLDLSQKELYKDVMKEILRNVVSIG 30
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-357 1.80e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 208 KCKQCGKAFPFPSSLQVHQR--IHTGE--KPYAC--KTCGKTFGHSSSLLRHERIHTGSSPHECKL--CKKTFTRLN--- 276
Cdd:COG5048   291 KSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnne 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 277 --SLLRHKIIHTGEKPYAC--NQCGKAFSRSASLQRHTRLHTGEKPYVCK--QCGKAFITSTYLQVHERTHTGEKPYVCK 350
Cdd:COG5048   371 ppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ....*..
gi 1039753533 351 ECGSTFM 357
Cdd:COG5048   451 ILKSFRR 457
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-30 1.57e-11

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 59.02  E-value: 1.57e-11
                          10        20
                  ....*....|....*....|....*....
gi 1039753533   2 EEWALLDLSQKELYKDVMKEILRNVVSIG 30
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
2-30 1.38e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.14  E-value: 1.38e-09
                           10        20
                   ....*....|....*....|....*....
gi 1039753533    2 EEWALLDLSQKELYKDVMKEILRNVVSIG 30
Cdd:smart00349  13 EEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-29 1.56e-09

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 53.32  E-value: 1.56e-09
                          10        20
                  ....*....|....*....|....*...
gi 1039753533   2 EEWALLDLSQKELYKDVMKEILRNVVSI 29
Cdd:cd07765    13 EEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-357 1.80e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 208 KCKQCGKAFPFPSSLQVHQR--IHTGE--KPYAC--KTCGKTFGHSSSLLRHERIHTGSSPHECKL--CKKTFTRLN--- 276
Cdd:COG5048   291 KSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnne 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 277 --SLLRHKIIHTGEKPYAC--NQCGKAFSRSASLQRHTRLHTGEKPYVCK--QCGKAFITSTYLQVHERTHTGEKPYVCK 350
Cdd:COG5048   371 ppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ....*..
gi 1039753533 351 ECGSTFM 357
Cdd:COG5048   451 ILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-330 6.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039753533 305 SLQRHTRLHTGEKPYVCKQCGKAFIT 330
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-30 1.57e-11

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 59.02  E-value: 1.57e-11
                          10        20
                  ....*....|....*....|....*....
gi 1039753533   2 EEWALLDLSQKELYKDVMKEILRNVVSIG 30
Cdd:pfam01352  14 EEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
2-30 1.38e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.14  E-value: 1.38e-09
                           10        20
                   ....*....|....*....|....*....
gi 1039753533    2 EEWALLDLSQKELYKDVMKEILRNVVSIG 30
Cdd:smart00349  13 EEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-29 1.56e-09

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 53.32  E-value: 1.56e-09
                          10        20
                  ....*....|....*....|....*...
gi 1039753533   2 EEWALLDLSQKELYKDVMKEILRNVVSI 29
Cdd:cd07765    13 EEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-357 1.80e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 208 KCKQCGKAFPFPSSLQVHQR--IHTGE--KPYAC--KTCGKTFGHSSSLLRHERIHTGSSPHECKL--CKKTFTRLN--- 276
Cdd:COG5048   291 KSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnne 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 277 --SLLRHKIIHTGEKPYAC--NQCGKAFSRSASLQRHTRLHTGEKPYVCK--QCGKAFITSTYLQVHERTHTGEKPYVCK 350
Cdd:COG5048   371 ppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450


                  ....*..
gi 1039753533 351 ECGSTFM 357
Cdd:COG5048   451 ILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-533 1.44e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 203 AKKCSKCKQCGKAFPFPSSLQVHQRIHTGEKPYAC--KTCGKTFGHSSSLLRHERIHTGSSPHEC-KLCKKTFTRLNSLL 279
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 280 RHKIIHTGEKPYACNQCGKAFSRSASLQRHTRLHTGEKPYVCKQC---GKAFITSTYLQV-------------------- 336
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnssSVNTPQSNSLHPplpanslskdpssnlsllis 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 337 HERTHTGEKPYVCKECGSTFMLWTQFQKHKIVHS---------------------------------------------- 370
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSssslplttnsqlspksllsqspsslsssdssssasesprsslptas 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 371 ----------------GVNPFVCKQCGKAFTRLGTLQIHER--IHTGE--KPYVC--KQCAKAFMSLTQLRRHEIIHSGI 428
Cdd:COG5048   270 sqssspnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 429 KPYMCK--QCGKGFL-----CSTTLRSHEKIHSGSNPYVC--SQCEKVVSSESALRKHKMIHTGEKPCVCK--QCGKTFT 497
Cdd:COG5048   350 SPAKEKllNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1039753533 498 HLSSLQYHALMHSGEKPHECKKCGKgFRSLSHLKKH 533
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-538 1.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 262 PHECKLCKKTFTRLNSLLRHKIIHTGEKPYACNQ--CGKAFSRSASLQRHTRLHTGEKPYVCKQCGK--AFITSTYLQVH 337
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 338 ERTHTgekPYVCKECGSTFMLWTQFQKHKIVHSGVNPFVCKQCGKAFTRLGTLQIHERIHTGEKPYVCKQCAKAFMSLTQ 417
Cdd:COG5048   113 SSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 418 LRRHEII------------------------HSGIKPYMCKQCGKGFLCS------TTLRSHEKIHSGSNPYVCSQCEKV 467
Cdd:COG5048   190 SNVSTSIpsssensplsssysipssssdqnlENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039753533 468 VSSESALRKHKMIHTG-EKPCVCKQCGKTFTHLSSLQYH--ALMHSGE--KPHECKK--CGKGFRSLSHLKKHERTQH 538
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-479 4.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 189 TSLSSLKRHEQHYHAKKCSKCKQCGKAFPFPSSLQVHQRIHTGEKPYACKTCGKTFGHSSSLLRHERIHTGSSPHECKLC 268
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 269 ------KKTFTRLNSLLRHKIIHTG-EKPYACNQCGKAFSRSASLQRHTR--LHTGE--KPYVC--KQCGKAFITSTYLQ 335
Cdd:COG5048   261 prsslpTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 336 VHERTHTGEKPYVCKECGSTfmlwtqfqkHKIVHSGVNPfvckqcgkaftRLGTLQIHERIHTgEKPYVC--KQCAKAFM 413
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSS---------SKFSPLLNNE-----------PPQSLQQYKDLKN-DKKSETlsNSCIRNFK 399

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039753533 414 SLTQLRRHEIIH--SGIKPYMCKQCGKGFLCSTTLRSHEKIHSGSNPYVCSQCEKVVSSESALRKHKM 479
Cdd:COG5048   400 RDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-330 6.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039753533 305 SLQRHTRLHTGEKPYVCKQCGKAFIT 330
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-311 1.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 177 KHHKCKH--CGKACTSLSSLKRHEQHYHAKKCSKCK--QCGKAFPFPS-----SLQVHQRIHTGEKPYAC--KTCGKTFG 245
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039753533 246 HSSSLLRHERIHTGSSPHECK--LCKKTFTRLNSLLRHKIIHTgEKPYACNQCGKAFSRSASLQRHTR 311
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-302 1.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039753533 277 SLLRHKIIHTGEKPYACNQCGKAFSR 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
221-244 3.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.03e-03
                          10        20
                  ....*....|....*....|....
gi 1039753533 221 SLQVHQRIHTGEKPYACKTCGKTF 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 166-253 3.40e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753533 166 GQNHERTPA------EEKHHKCK--HCGKACTSLSSLKRHEQHYHakkcskCKQCGKAFPFPSSlqvHQRIHTGEKPYAC 237
Cdd:COG5189   331 GERNIDTPSrmlkvkDGKPYKCPveGCNKKYKNQNGLKYHMLHGH------QNQKLHENPSPEK---MNIFSAKDKPYRC 401

                          90
                  ....*....|....*.
gi 1039753533 238 KTCGKTFGHSSSLLRH 253
Cdd:COG5189   402 EVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-356 4.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|....
gi 1039753533 333 YLQVHERTHTGEKPYVCKECGSTF 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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