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Conserved domains on  [gi|1039759606|ref|XP_017172057|]
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tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5 [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-146 5.21e-67

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16097:

Pssm-ID: 472250  Cd Length: 111  Bit Score: 204.33  E-value: 5.21e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVTPA 114
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039759606 115 DAGIYYCVKFQKGSSePDTEIQSGGGTEVYVL 146
Cdd:cd16097    81 DAGTYYCVKFRKGSP-DDVEFKSGAGTELSVR 111
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 35-146 5.21e-67

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 204.33  E-value: 5.21e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVTPA 114
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039759606 115 DAGIYYCVKFQKGSSePDTEIQSGGGTEVYVL 146
Cdd:cd16097    81 DAGTYYCVKFRKGSP-DDVEFKSGAGTELSVR 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 38-146 6.09e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 74.80  E-value: 6.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  38 QPEKSVSVAAGDSTVLNCTLTSL--LPVGPIRWYRG--VGPSRLLIYSFAGEYVPRIR--NVSDTTKRNNMDFSIRISNV 111
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmsEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKkgRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039759606 112 TPADAGIYYCVKFqkgssePDTEIQSGGGTEVYVL 146
Cdd:pfam07686  81 TLSDSGTYTCAVI------PSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 41-145 2.40e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 2.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606   41 KSVSVAAGDSTVLNCTLTSLlPVGPIRWYRGvgPSRLLIYSfageyvPRIrnvsdTTKRNNMDFSIRISNVTPADAGIYY 120
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYKQ--GGKLLAES------GRF-----SVSRSGSTSTLTISNVTPEDSGTYT 67

                           90       100
                   ....*....|....*....|....*.
gi 1039759606  121 C-VKFQKGSSEpdteiqsgGGTEVYV 145
Cdd:smart00410  68 CaATNSSGSAS--------SGTTLTV 85
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 35-146 5.21e-67

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 204.33  E-value: 5.21e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVTPA 114
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039759606 115 DAGIYYCVKFQKGSSePDTEIQSGGGTEVYVL 146
Cdd:cd16097    81 DAGTYYCVKFRKGSP-DDVEFKSGAGTELSVR 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 36-145 1.14e-22

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 90.09  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGV-GPSRLLIYSFAGEYVPRIRNVSD---TTKRNNMDFSIRISNV 111
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKpGQGPEFLIYLSSSKGKTKGGVPGrfsGSRDGTSSFSLTISNL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1039759606 112 TPADAGIYYCVKFQKGSSEPDTeiqSGGGTEVYV 145
Cdd:cd00099    81 QPEDSGTYYCAVSESGGTDKLT---FGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 38-146 6.09e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 74.80  E-value: 6.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  38 QPEKSVSVAAGDSTVLNCTLTSL--LPVGPIRWYRG--VGPSRLLIYSFAGEYVPRIR--NVSDTTKRNNMDFSIRISNV 111
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmsEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKkgRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039759606 112 TPADAGIYYCVKFqkgssePDTEIQSGGGTEVYVL 146
Cdd:pfam07686  81 TLSDSGTYTCAVI------PSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 36-145 1.31e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 57.28  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSLLPVGpIRWYR---GVGPSRLLIYSFAGEYVPRIRnVSDTTKRNNMDFSIRISNVT 112
Cdd:cd04983     1 VTQSPQSLSVQEGENVTLNCNYSTSTFYY-LFWYRqypGQGPQFLIYISSDSGNKKKGR-FSATLDKSRKSSSLHISAAQ 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039759606 113 PADAGIYYCVKFQKGSSEpdtEIQSGGGTEVYV 145
Cdd:cd04983    79 LSDSAVYFCALSESGGTG---KLTFGKGTRLTV 108
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 36-143 5.62e-10

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 55.47  E-value: 5.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWY--RGVGPSRLLIYS-----------FAGEYvprirnvSDTtkrnnm 102
Cdd:cd04980     3 MTQSPASLSVSPGERVTISCKASQSISSNYLAWYqqKPGQAPKLLIYYastlhsgvpsrFSGSG-------SGT------ 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1039759606 103 DFSIRISNVTPADAGIYYCvkfQKGSSEPDTeiqSGGGTEV 143
Cdd:cd04980    70 DFTLTISSVEPEDAAVYYC---QQGYTFPYT---FGGGTKL 104
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 41-145 2.40e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 2.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606   41 KSVSVAAGDSTVLNCTLTSLlPVGPIRWYRGvgPSRLLIYSfageyvPRIrnvsdTTKRNNMDFSIRISNVTPADAGIYY 120
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYKQ--GGKLLAES------GRF-----SVSRSGSTSTLTISNVTPEDSGTYT 67

                           90       100
                   ....*....|....*....|....*.
gi 1039759606  121 C-VKFQKGSSEpdteiqsgGGTEVYV 145
Cdd:smart00410  68 CaATNSSGSAS--------SGTTLTV 85
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 36-129 2.95e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 45.43  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSL-LPVGPIRWYR---GVGPSRLLIYSfageYVPRIRNVSDTTK--------RNNMD 103
Cdd:cd04982     1 LEQPQLSITREESKSVTISCKVSGIdFSTTYIHWYRqkpGQALERLLYVS----STSAVRKDSGKTKnkfearkdVGKST 76

                          90       100
                  ....*....|....*....|....*.
gi 1039759606 104 FSIRISNVTPADAGIYYCVKFQKGSS 129
Cdd:cd04982    77 STLTITNLEKEDSATYYCAYWESGSG 102
IGv smart00406
Immunoglobulin V-Type;
53-121 5.10e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 43.91  E-value: 5.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039759606   53 LNCTL-TSLLPVGPIRWYR---GVGPSRLLIYSFAGE------YVPRIrNVSDTTKRNnmDFSIRISNVTPADAGIYYC 121
Cdd:smart00406   4 LSCKFsGSTFSSYYVSWVRqppGKGLEWLGYIGSNGSsyyqesYKGRF-TISKDTSKN--DVSLTISNLRVEDTGTYYC 79
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 36-133 6.00e-06

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 44.36  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSLLP--VGPIRWYRGVGPSRLLI--------YSFAGEYVPRIRNVSDTTKRNNMdfS 105
Cdd:cd05718     2 RVQVPTEVTGFLGGSVTLPCSLTSPGTtkITQVTWMKIGAGSSQNVavfhpqygPSVPNPYAERVEFLAARLGLRNA--T 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039759606 106 IRISNVTPADAGIYYC--VKFQKGSSEPDT 133
Cdd:cd05718    80 LRIRNLRVEDEGNYICefATFPQGNRQGTT 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 38-122 6.63e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 43.72  E-value: 6.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  38 QPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWyrgvgpsrlliySFAGEYVPRIRNVSDTTKRNnMDFSIRISNVTPADAG 117
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTW------------SKEGGTLIESLKVKHDNGRT-TQSSLLISNVTKEDAG 67


                  ....*
gi 1039759606 118 IYYCV 122
Cdd:pfam00047  68 TYTCV 72
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 36-145 8.62e-06

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 43.99  E-value: 8.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEkSVSVAAGDSTVLNCTLTSLLPVGP-IRWYRGVGPS--RLLIY--SFAGEYVP-RIRNVSDTTKRnnmdfSIRIS 109
Cdd:cd04984     2 LTQPS-SLSVSPGETVTITCTGSSGNISGNyVNWYQQKPGSapRYLIYedKHRPSGIPdRFSGSKSGNTA-----SLTIS 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1039759606 110 NVTPADAGIYYCVKFQKGSsepdteIQSGGGTEVYV 145
Cdd:cd04984    76 GAQTEDEADYYCQVWDSNS------YVFGGGTKLTV 105
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
 38-121 1.41e-05

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 42.83  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  38 QPEKSVSVAAGDSTVLNCTLTSLLpvGPIRWY--RGVGPsrlliysfaGEYVPRIRNVSDTtkrnnmdfSIRISNVTPAD 115
Cdd:cd04979     1 TSFKQISVKEGDTVILSCSVKSNN--APVTWIhnGKKVP---------RYRSPRLVLKTER--------GLLIRSAQEAD 61


                  ....*.
gi 1039759606 116 AGIYYC 121
Cdd:cd04979    62 AGVYEC 67
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 35-129 2.66e-05

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 42.56  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTsllpvgP--------IRWYRGvGPSRL-LIY----SFAGEYVPRIRN----VSDTT 97
Cdd:cd05713     2 SVIGPTEPILALVGEDAELPCHLS------PkmsaehmeVRWFRS-QFSPVvHLYrdgqDQEEEQMPEYRGrtelLKDAI 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039759606  98 KRNNMdfSIRISNVTPADAGIYYCVkFQKGSS 129
Cdd:cd05713    75 AEGSV--ALRIHNVRPSDEGQYTCF-FRSGSF 103
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 35-122 2.71e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.78  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSllpvGP---IRWYRGVGPSrlliysfageyvprIRNVSDTTKRNNMDFSIRISNV 111
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATG----SPpptITWYKNGEPI--------------SSGSTRSRSLSGSNSTLTISNV 64

                          90
                  ....*....|.
gi 1039759606 112 TPADAGIYYCV 122
Cdd:pfam13927  65 TRSDAGTYTCV 75
I-set pfam07679
Immunoglobulin I-set domain;
35-122 4.06e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSLlPVGPIRWYRG---VGPSRLLiysfageyvpRIRNVSDTTkrnnmdfSIRISNV 111
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTGT-PDPEVSWFKDgqpLRSSDRF----------KVTYEGGTY-------TLTISNV 63

                          90
                  ....*....|.
gi 1039759606 112 TPADAGIYYCV 122
Cdd:pfam07679  64 QPDDSGKYTCV 74
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 35-145 4.61e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 39.04  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  35 KVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGV--GPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVT 112
Cdd:cd07706     1 KVTQAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLpsGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQ 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1039759606 113 PADAGIYYCVKfqkgSSEPDTE-IQSGGGTEVYV 145
Cdd:cd07706    81 LEDSAKYFCAL----SLPYDTDkLIFGKGTRLTV 110
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 39-122 1.04e-03

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 37.39  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  39 PEKSVSVAAGDSTVLNCtLTSLLPVGPIRWYRGVGPsrlliysfageyVPrirnvSDTTKRNNMDFSIRISNVTPADAGI 118
Cdd:cd05731     1 SESSTMVLRGGVLLLEC-IAEGLPTPDIRWIKLGGE------------LP-----KGRTKFENFNKTLKIENVSEADSGE 62


                  ....
gi 1039759606 119 YYCV 122
Cdd:cd05731    63 YQCT 66
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 52-122 1.86e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 1.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039759606  52 VLNCTLTSLlPVGPIRWYRGvgpsrlliysfaGEYVPRIRNVSDTTKRNNmdFSIRISNVTPADAGIYYCV 122
Cdd:cd00096     2 TLTCSASGN-PPPTITWYKN------------GKPLPPSSRDSRRSELGN--GTLTISNVTLEDSGTYTCV 57
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 38-145 1.96e-03

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 37.43  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  38 QPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYR-GVGPSR------LLIYSFA-----GEYVPRIRNV--SDTTKRNnmd 103
Cdd:cd07700     3 QTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRqRQAPSKdshfefLASWDPSkgivyGEGVDQEKLIilSDSDSSR--- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039759606 104 FSIRISNVTPADAGIYYCVKFqkGSSepdtEIQSGGGTEVYV 145
Cdd:cd07700    80 YILSLMSVKPEDSGTYFCMTV--GSP----ELIFGTGTKLSV 115
IgI_VEGFR cd05862
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); ...
 39-121 3.10e-03

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.


Pssm-ID: 409448  Cd Length: 102  Bit Score: 36.65  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  39 PEKSVSVAAGDSTVLNCTLTSLLPVG-PIRW-YRGVGPSRlliysfaGEYVPRIRNVSDTTKrNNMDFSIRISNVTPADA 116
Cdd:cd05862     7 PPKPVELLVGEKLVLNCTARTELNVGvDFQWdYPGKKEQR-------RASVRRRRKQQSSEA-TEFSSTLTIDNVTLSDK 78


                  ....*
gi 1039759606 117 GIYYC 121
Cdd:cd05862    79 GLYTC 83
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 33-121 3.78e-03

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 36.17  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  33 ELKVTQPEksvSVAAGDSTVLNCTLTSLLPVGPIRWYR--GVGPSRLLIYS------FAGEYVPRIRnvsdTTKRNNMDF 104
Cdd:cd05846     1 VVVHTGDT---RAVLGGNATLSCNLTLPEEVLQVTWQKikASSPENIVTYSkkygvkIQPSYVRRIS----FTSSGLNST 73

                          90
                  ....*....|....*..
gi 1039759606 105 SIRISNVTPADAGIYYC 121
Cdd:cd05846    74 SITIWNVTLEDEGCYKC 90
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 86-136 3.91e-03

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 36.38  E-value: 3.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039759606  86 YVPRIRNVSDTTKRNNMDFSIRisNVTPADAGIYYC--VKFQKGSSEPDTEIQ 136
Cdd:cd05889    59 YAGRVYFLNSTMASNNMSLSFR--NASEDDVGYYSCslYTYPQGSWEKVIQVV 109
IgI_Perlecan_like cd05754
Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of ...
 36-122 4.11e-03

Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain found in Perlecan. Perlecan is a large multi-domain heparin sulfate proteoglycan, important in tissue development and organogenesis. Perlecan can be represented as 5 major portions; its fourth major portion (domain IV) is a tandem repeat of immunoglobulin-like domains (Ig2-Ig15) which can vary in size due to alternative splicing. Perlecan binds many cellular and extracellular ligands. Its domain IV region has many binding sites. Some of these have been mapped at the level of individual Ig-like domains, including a site restricted to the Ig5 domain for heparin/sulfatide, a site restricted to the Ig3 domain for nidogen-1 and nidogen-2, a site restricted to Ig4-5 for fibronectin, and sites restricted to Ig2 and to Ig13-15 for fibulin-2. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409412  Cd Length: 85  Bit Score: 35.61  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  36 VTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPsrlliysfageyVPRirnvsdttkrNNMDFS--IRISNVTP 113
Cdd:cd05754     4 TVEEPRSQEVRPGADVSFICRAKSKSPAYTLVWTRVNGT------------LPS----------RAMDFNgiLTIRNVQL 61


                  ....*....
gi 1039759606 114 ADAGIYYCV 122
Cdd:cd05754    62 SDAGTYVCT 70
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 34-123 5.58e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 35.89  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  34 LKVTQPEKSVSVAAGDSTVLNCTLT-SLLPVGP--IRWYrgVGPSR-----LLIYS----FAGEYVPRIRNVSDTTKRNN 101
Cdd:cd20960     1 LLITSAQTEIKKVAGENVTLPCHHQlGLEDQGTldIEWL--LLPSDkvekvVITYSgdrvYNHYYPALKGRVAFTSNDLS 78

                          90       100
                  ....*....|....*....|...
gi 1039759606 102 MDFSIRISNVTPADAGIYYC-VK 123
Cdd:cd20960    79 GDASLNISNLKLSDTGTYQCkVK 101
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 34-121 9.47e-03

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 35.48  E-value: 9.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039759606  34 LKVTQPeKSVSVAAGDSTVLNCTLTSLLPVG---PIRW-YR--GVGPSRLLIYSFAGEYVP--------RIRNVSDTTKR 99
Cdd:cd05715     1 MEVYTP-RELNVLNGSDVRLTCTFTSCYTVGdafSVTWtYQpeGGNTTESMFHYSKGKPYIlkvgrfkdRVSWAGNPSKK 79

                          90       100
                  ....*....|....*....|..
gi 1039759606 100 nnmDFSIRISNVTPADAGIYYC 121
Cdd:cd05715    80 ---DASIVISNLQFSDNGTYTC 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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