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Conserved domains on  [gi|1039747971|ref|XP_017171853|]
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solute carrier family 45 member 4 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 53-275 1.30e-78

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 259.10  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  53 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 132
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 133 IGVALFLNGSAIGLALGDvpSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 212
Cdd:cd17313    81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039747971 213 VLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGT 275
Cdd:cd17313   159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEV 221
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 514-726 2.94e-49

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 179.36  E-value: 2.94e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 514 LWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGnpqapsNSTKWHAYNAGVKMGCWGLVIYAATGAICS 593
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 594 ALLQKYLDNYdlSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDikeyvhhspgNS 673
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039747971 674 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVNSIVVIPIVASVGSFLGFLT 726
Cdd:cd17313   367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 53-275 1.30e-78

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 259.10  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  53 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 132
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 133 IGVALFLNGSAIGLALGDvpSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 212
Cdd:cd17313    81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039747971 213 VLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGT 275
Cdd:cd17313   159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEV 221
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 514-726 2.94e-49

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 179.36  E-value: 2.94e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 514 LWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGnpqapsNSTKWHAYNAGVKMGCWGLVIYAATGAICS 593
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 594 ALLQKYLDNYdlSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDikeyvhhspgNS 673
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039747971 674 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVNSIVVIPIVASVGSFLGFLT 726
Cdd:cd17313   367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 48-215 1.87e-23

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 104.50  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  48 IPTRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILAl 127
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 128 cVGVLIGVALFLNGSA--IGLALGD--VPSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHA 201
Cdd:TIGR01301  80 -GAALVAFAVILIGFAadIGHLFGDnlDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFS 158

                         170
                  ....*....|....
gi 1039747971 202 FSAGLGGAIGYVLG 215
Cdd:TIGR01301 159 FFMAIGNVLGYAAG 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
46-263 3.55e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.16  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  46 DRIPTRLWVMHGAVMFGREFCYAMETALVTPILLQI-GLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFI 124
Cdd:COG2211     5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 125 LALCVG-VLIGVALFLngsaiglalgdVPSRQPIG-IVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHA 201
Cdd:COG2211    85 LIGAIPlALSFVLLFT-----------APDLSPTGkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039747971 202 FSAGLGGAIGYVLGGLdwTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQ 263
Cdd:COG2211   154 AFAGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE 213
MFS_1 pfam07690
Major Facilitator Superfamily;
65-258 1.46e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  65 FCYAMETALVTPILLQI-----GLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALFL 139
Cdd:pfam07690   6 FLAALGRSLLGPALPLLlaedlGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 140 NGSAIGLALgdvpSRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldw 219
Cdd:pfam07690  82 ASSLWLLLV----LRVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--- 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039747971 220 tqtFLGDWFQTqnQVLFFFAAVIFSVSVALHLFSIEEEQ 258
Cdd:pfam07690 143 ---LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPE 176
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
516-748 2.00e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 516 LSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIfkGNPQApsnstkwhaynagvkMGCWGLVIYAATGAICSAL 595
Cdd:COG2211   221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAA---------------LVGLLLALYFLAALLGAPL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 596 LQKYLDNYDLsiRIIYMLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGVVSMSISYCPYALLGhyhDIKEYVHHSPGns 673
Cdd:COG2211   284 WPRLAKRFGK--KKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 674 KRGFGIDCAILSCQVYISQILVASALGGVVDAV----------NSIVVIPIVASVGSFLGFLTATFLVI-YPEVSEEPKE 742
Cdd:COG2211   357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLLLfYPLTRERHAE 436


                  ....*.
gi 1039747971 743 EQKGLS 748
Cdd:COG2211   437 IRAELA 442
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 516-736 6.64e-05

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 46.34  E-value: 6.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 516 LSMLKMPkelMW-LCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQapsnstKWHAYNAGVKMGCWGLVIYAATGAICSA 594
Cdd:TIGR01301 253 FKYLPRP---VWiLLLVTCLNWIAWFPFILFDTDWMGREVYGGSVN------QGAKYDDGVRAGAFGLMLNSVVLGITSI 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 595 LLQKYLDNYDLSIR---IIYMLGTLGFSVGTAVMAMFPN----------------VYVAMVTISTMGVVSMSISYC-PYA 654
Cdd:TIGR01301 324 GMEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgIKASALIVFAILGIPLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 655 LLGHYHDikeyvhhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVNSIVVIP--IVASVGSFLGFLTATFLVI 732
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 1039747971 733 YPEV 736
Cdd:TIGR01301 473 RPRV 476
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 53-275 1.30e-78

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 259.10  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  53 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 132
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 133 IGVALFLNGSAIGLALGDvpSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 212
Cdd:cd17313    81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039747971 213 VLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGT 275
Cdd:cd17313   159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEV 221
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 514-726 2.94e-49

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 179.36  E-value: 2.94e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 514 LWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGnpqapsNSTKWHAYNAGVKMGCWGLVIYAATGAICS 593
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 594 ALLQKYLDNYdlSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDikeyvhhspgNS 673
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039747971 674 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVNSIVVIPIVASVGSFLGFLT 726
Cdd:cd17313   367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 48-215 1.87e-23

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 104.50  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  48 IPTRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILAl 127
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 128 cVGVLIGVALFLNGSA--IGLALGD--VPSRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHA 201
Cdd:TIGR01301  80 -GAALVAFAVILIGFAadIGHLFGDnlDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFS 158

                         170
                  ....*....|....
gi 1039747971 202 FSAGLGGAIGYVLG 215
Cdd:TIGR01301 159 FFMAIGNVLGYAAG 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 59-277 2.44e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.46  E-value: 2.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  59 VMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALF 138
Cdd:cd06174     4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR----FGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 139 LNGSAIGLALGDVpsrqpigivltvlgvvVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGld 218
Cdd:cd06174    80 FAPSFWLLLLGRF----------------LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG-- 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039747971 219 wtqtFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPEDPTLPGTSV 277
Cdd:cd06174   142 ----ILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL 196
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
46-263 3.55e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.16  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  46 DRIPTRLWVMHGAVMFGREFCYAMETALVTPILLQI-GLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFI 124
Cdd:COG2211     5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 125 LALCVG-VLIGVALFLngsaiglalgdVPSRQPIG-IVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHA 201
Cdd:COG2211    85 LIGAIPlALSFVLLFT-----------APDLSPTGkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039747971 202 FSAGLGGAIGYVLGGLdwTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFSIEEEQYSPQQ 263
Cdd:COG2211   154 AFAGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE 213
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 22-249 1.32e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.50  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  22 LPDPQKPRDPEAETQEETTSEGSIDRIPTRLWVMHGAVMFGREFCYAMETALvtPILLQ--IGLPEKYYSLTWFLSPVLG 99
Cdd:cd17325   171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL--PLYAAelGGLSPAQIGLLFGAQGLAS 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 100 LIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALFLNGSAIGLALGdvpsrqpigivltvlgVVVLDFSADATEGP 179
Cdd:cd17325   249 ALSQPPAGKLSDR----IGRKPLILIGLLLSAVALLLLPLATSFWLLLLL----------------LALLGLGLGLVFPA 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 180 IRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGDWFQTQNqvLFFFAAVIFSVSVAL 249
Cdd:cd17325   309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG------FLYDAFGFAT--PFLAAAALLLLAAVL 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
52-256 1.92e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.82  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  52 LWVMHGAVMFGRefcyAMETALVTPILLQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCVGV 131
Cdd:COG2814    15 LALGAFLSGLGI----GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGRRRVLLLGLLLFA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 132 LIGVALFLNGSAIGLALGdvpsRQPIGIvltvlgvvvldfsADATEGPI-RAYLLDVVDSEEQDMALNIHAFSAGLGGAI 210
Cdd:COG2814    87 LGSLLCALAPSLWLLLAA----RFLQGL-------------GAGALFPAaLALIADLVPPERRGRALGLLGAGLGLGPAL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1039747971 211 GYVLGGldwtqtFLGDWFQTqnQVLFFFAAVIFSVSVALHLFSIEE 256
Cdd:COG2814   150 GPLLGG------LLADLFGW--RWVFLVNAVLALLALLLLLRLLPE 187
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 65-252 3.78e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.97  E-value: 3.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  65 FCYAMETALVTPILLQIGLPEKYYSLTWFLS-------PVLGLIFTPLIGSASDRctlsWGRRRPFILALCvGVLIGVAL 137
Cdd:cd17330     6 FLDALGFGIVFPVLPFYVREFNKLGASGYYVgllqssySLGQFLASPLWGRLSDR----YGRKPVLLLSLA-GSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 138 FLNGSAIGLALGdvpSRQPIGIVLtvlgvvvldfsadATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGl 217
Cdd:cd17330    81 LGLSRNLWLLFL---ARFLDGLTG-------------GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGG- 143

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1039747971 218 dwtqtFLGDWFqtQNQVLFFFAAVIFSVSVALHLF 252
Cdd:cd17330   144 -----FLSTPY--GYALPFLVAAALALLNLVLVLF 171
MFS_1 pfam07690
Major Facilitator Superfamily;
65-258 1.46e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  65 FCYAMETALVTPILLQI-----GLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALFL 139
Cdd:pfam07690   6 FLAALGRSLLGPALPLLlaedlGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 140 NGSAIGLALgdvpSRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldw 219
Cdd:pfam07690  82 ASSLWLLLV----LRVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--- 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039747971 220 tqtFLGDWFQTqnQVLFFFAAVIFSVSVALHLFSIEEEQ 258
Cdd:pfam07690 143 ---LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPE 176
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-257 3.93e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  58 AVMFGREFCYAMetalVTPIL----LQIGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLI 133
Cdd:cd17325     3 LALFLDMLGYGI----IIPILplyaESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR----FGRKRLLLLGLLLLAVS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 134 GVALFLNGSAIGLALgdvpSRQPIGIvltvlgvvvldfsADATEGPIR-AYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 212
Cdd:cd17325    75 TLLFAFATSYWQLLL----ARFLQGL-------------ASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGP 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1039747971 213 VLGGldwtqtFLGDWFQTqnQVLFFFAAVIFSVSVALHLFSIEEE 257
Cdd:cd17325   138 LLGG------LLADALGY--RAPFLVCAALALLALVLALLLLPEP 174
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 52-268 7.81e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 48.76  E-value: 7.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  52 LWVMHGAVMFGReFCYAMETALVTPILLQiglpEKYYSLTW-----FLSPVLGLIFTPLIGSASDRctlsWGRRrPFILA 126
Cdd:cd17329     1 LWVLLIGSFLNR-LGFFMVWPFMAIYLHQ----QLGLSASIvglvlALSAVAGIVASLIGGRLADR----FGRK-PVMLA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 127 LCVGVLIGVALF-----LNGSAIGLALgdvpsrqpIGivltvlgvvvldFSADATEGPIRAYLLDVVDSEEQDMALNIHA 201
Cdd:cd17329    71 GLLLRALGFALLgfahsPWLFAIALVL--------TG------------FGGGLFEPASEAMIADVTTPENRTRAFSLLY 130

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039747971 202 FSAGLGGAIGYVLGGLdwtqtFLGDWFQTqnqvLFFFAAVIFSVSVALHLFSIEEEQYSPQQDRGPE 268
Cdd:cd17329   131 WAINLGVAIGPLLGGL-----LLLYSFRL----LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTE 188
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 27-251 1.23e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  27 KPRDPEAETQEETTSEGSIDRIPTRLWVMHGAVMFGrEFCYAMETALVTpILLQIGLPEKYYSLTWFLSPVLGLIFTPLI 106
Cdd:cd17370   177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALF-ALGNFSFAFLIL-RAQELGLSAALIPLLYALFNLVYALAAYPA 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 107 GSASDRctlsWGRRRPFILALCVGVLIGVALFLNGSAIGLALGDVPSrqpiGIVLTvlgvvvldfsadATEGPIRAYLLD 186
Cdd:cd17370   255 GRLSDR----IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW----GLYMG------------AQESIERAAVAD 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039747971 187 VVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLgdwfqtqnQVLFFFAAVIFSVSVALHL 251
Cdd:cd17370   315 LVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP--------SAAFLFSAVLALIALLLLL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
516-748 2.00e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 516 LSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIfkGNPQApsnstkwhaynagvkMGCWGLVIYAATGAICSAL 595
Cdd:COG2211   221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAA---------------LVGLLLALYFLAALLGAPL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 596 LQKYLDNYDLsiRIIYMLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGVVSMSISYCPYALLGhyhDIKEYVHHSPGns 673
Cdd:COG2211   284 WPRLAKRFGK--KKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 674 KRGFGIDCAILSCQVYISQILVASALGGVVDAV----------NSIVVIPIVASVGSFLGFLTATFLVI-YPEVSEEPKE 742
Cdd:COG2211   357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLLLfYPLTRERHAE 436


                  ....*.
gi 1039747971 743 EQKGLS 748
Cdd:COG2211   437 IRAELA 442
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 516-725 3.53e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 516 LSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVifkgnpqapsnstkwhaYNAGVKMGCWGLVIYAATGAICSAL 595
Cdd:cd06174   196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL-----------------GGLSVAVAGLLLSLFGLAGALGSLL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 596 LQKYLDnYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHdikeyvhhspgnSKR 675
Cdd:cd06174   259 LGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF------------PPE 325

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039747971 676 GFGIDCAILSCQVYISQILVASALGGVVDAVNSIVVIPIVASVGSFLGFL 725
Cdd:cd06174   326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
28-210 5.30e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  28 PRDPEAETQEETTSEGSIDRIPTRLWVMHGAVMFGreFCYAMETALVTPILLQI-GLPEKYYSLTWFLSPVLGLIFTPLI 106
Cdd:COG2814   186 PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG--FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 107 GSASDRctlsWGRRRPFILALCVGVLIGVALFLNGSAIGLALGdvpsrqpigivltvlgVVVLDFSADATEGPIRAYLLD 186
Cdd:COG2814   264 GRLADR----FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA----------------LFLLGFGFGLLFPLLQALVAE 323

                         170       180
                  ....*....|....*....|....
gi 1039747971 187 VVDSEEQDMALNIHAFSAGLGGAI 210
Cdd:COG2814   324 LAPPEARGRASGLYNSAFFLGGPL 347
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 516-736 6.64e-05

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 46.34  E-value: 6.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 516 LSMLKMPkelMW-LCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQapsnstKWHAYNAGVKMGCWGLVIYAATGAICSA 594
Cdd:TIGR01301 253 FKYLPRP---VWiLLLVTCLNWIAWFPFILFDTDWMGREVYGGSVN------QGAKYDDGVRAGAFGLMLNSVVLGITSI 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 595 LLQKYLDNYDLSIR---IIYMLGTLGFSVGTAVMAMFPN----------------VYVAMVTISTMGVVSMSISYC-PYA 654
Cdd:TIGR01301 324 GMEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgIKASALIVFAILGIPLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 655 LLGHYHDikeyvhhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVNSIVVIP--IVASVGSFLGFLTATFLVI 732
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 1039747971 733 YPEV 736
Cdd:TIGR01301 473 RPRV 476
MFS_1 pfam07690
Major Facilitator Superfamily;
20-211 9.37e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 9.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  20 VPLPDPQKPRDPEAETQEETTSEG-SIDRIPTRLWVMHGAVMFGreFCYAMETALVTPILLQIGLPEKYYSLTWFLSPVL 98
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAwKALLRDPVLWLLLALLLFG--FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  99 GLIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALFLnGSAIGLALGDVPSRQPIGivltvlgvvvldFSADATEG 178
Cdd:pfam07690 248 GAIGRLLLGRLSDR----LGRRRRLLLALLLLILAALGLLL-LSLTLSSLWLLLALLLLG------------FGFGLVFP 310

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1039747971 179 PIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIG 211
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-250 1.16e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.11  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  18 LPVPLPDPQKPRDPEAETQEETTSEGSIDRIPtRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEKYYSLTWFLSPV 97
Cdd:cd06174   172 VVPDPPESARAKNEEASSKSVLKLLKRVLKNP-GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  98 LGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLIGVALFLNGSAIGLALGDVpsrQPIGivltvlgvvvldFSADATE 177
Cdd:cd06174   251 AGALGSLLLGLLSDR----LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL---LLLG------------FGLGGLL 311

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039747971 178 GPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGDWFQTQNQVLFFFAAVIFSVSVALH 250
Cdd:cd06174   312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG------FLLAATFGLTGAFLVLAVLLLLAAILLL 378
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 49-255 4.32e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.26  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  49 PTRLWVMHGAVMFGReFCYAMETALVTPILLQI----GLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFI 124
Cdd:COG0477     9 TRRRRRALLALALGT-FLEGLDFTIVNVALPSIaadlGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR----YGRKRVLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 125 lalcvgvlIGVALFLNGSAIGLALGDVP----SR--QPIGIvltvlgvvvldfsadATEGPI-RAYLLDVVDSEEQDMAL 197
Cdd:COG0477    84 --------IGLLLFGLASLLCGLAPSPElliaARalQGIGA---------------GGLMPGaLALIAELFPARERGRAL 140

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039747971 198 NIHAFSAGLGGAIGYVLGGldWTQTFLGdWfqtqnQVLFFFAAVIFSVSVALHLFSIE 255
Cdd:COG0477   141 GLWGAAIGLGLALGPLLGG--LLVAALG-W-----RWIFLINAPLGLLALVLRLRLPE 190
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 97-249 5.94e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.98  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  97 VLGLIFTPLIGSASDRctlsWGRRrpFILALCVgVLIGVALFLNGSAIGLALGdVPSRQPIGIVLTvlgvvvldfsadaT 176
Cdd:cd17390    42 ALQLFSSPLVGSWSDV----VGRR--PVLLICL-LLTALGYVLLGFSTSLALL-FLSRIPLGIFKH-------------T 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039747971 177 EGPIRAYLLDVVDSEEQDMAL-NIHAFSaGLGGAIGYVLGGldwtqtFLGdwfQTQN--QVLFFFAAVIFSVSVAL 249
Cdd:cd17390   101 QSLCKAYLSDLVSEQERSRVLgRFNAAS-SLGFILGPVVGG------HLA---ETDGgfYYVALLCSAIFILNAGL 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
51-259 6.20e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  51 RLWVMHGAVMFGREFCYAMETALVTPILLQ-IGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILALCV 129
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKKAFIIGLLL 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 130 GVLIGVAL-FLNGSAIGLALGdvpsrqPIGIVLtvlgvvvldFSADATEGPIRAYLLDVVDSEEQD-------MALNIHA 201
Cdd:COG2211   304 AALGLLLLfFLGPGNLWLLLV------LAALAG---------IGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFT 368

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039747971 202 FSAGLGGAIGYVLGG--LDWTQtFLGDWFQTQN------QVLFFFAAVIFSVS-VALHLFSIEEEQY 259
Cdd:COG2211   369 FAIKLGQALAGALAGllLALFG-YVAGAAQSPSaltgirLLFFLLPAVLLLLAaLLLLFYPLTRERH 434
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 81-140 7.11e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 42.68  E-value: 7.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  81 IGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLIGVALFLN 140
Cdd:pfam13347  28 LGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFT 87
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 87-217 1.24e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.06  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  87 YYSLTWFLSPVLGLIFTPLIGSASDRCtlswGRRRPFILALC-VGVLIGVALFLNG------SAIGLALGDVpsrqpigi 159
Cdd:COG2270    53 LWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTlLGVLATAALFFVApgglwlGLLLFVLANI-------- 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039747971 160 vltvlgvvvldfSADATEGPIRAYLLDVVDSEEQDMAlnihafsAGLGGAIGYVLGGL 217
Cdd:COG2270   121 ------------GFEGSLVFYNAFLPDIATPEEIGRV-------SGLGWALGYLGGVL 159
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 67-249 1.58e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.41  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  67 YAMETALVTPIL------LQIGLPEKYYSLTWFLspVLGLIFTPLIGSASDRctlsWGRRRPFILALCV---GVLIG--- 134
Cdd:cd17504     8 VMLVETMLSPALptiqreFGTSAAAVSWVLTAYL--LVGAVSTPILGRLGDL----YGRKKVLLIVLAIytaGSLLAafa 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 135 --VALFLNGSAI-GLALGDVPsrqpIGIvltvlgvvvldfsadateGPIRayllDVVDSEEQDMALNIHAFSAGLGGAIG 211
Cdd:cd17504    82 pnLPVLIAGRALqGIGGAVFP----LAF------------------ALVR----EEFPPERVPVAQGILSATFGIGAGIG 135

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1039747971 212 YVLGGldWTQTFLGdWfqtqnQVLFFFAAVIFSVSVAL 249
Cdd:cd17504   136 LPLGG--WIVQHLG-W-----RWIFWTAAPVAVLLAAL 165
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 92-139 1.77e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.44  E-value: 1.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039747971  92 WFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALcvGVLIGVALFL 139
Cdd:cd17332    41 FLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWG--AIPLALLFVL 86
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
580-734 3.04e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 580 WGLVIYAATGAICSALLQKYldnydlSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHY 659
Cdd:COG2271    53 AFFLGYALGQIPAGLLADRF------GRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 660 HDIKEyvhhspgnskRGFGIdcAILSCQVYISQILVASALGGVVDAVN------SIVVIPIVASVGSFLGFLTATFLVIY 733
Cdd:COG2271   127 FPPKE----------RGRAL--GIFNAGGPLGGALAPPLLGWLLAAFGwraaflILGLPGLLLALLRFWLLALAYFLVYF 194


                  .
gi 1039747971 734 P 734
Cdd:COG2271   195 A 195
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 529-659 4.03e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.23  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 529 CLCHLLTWFSVIAEAVFYTDFMgqvifkgnpQAPSNSTKWHAYNAGVKMGCwglviYAATGAICSALLQKYldnydlSIR 608
Cdd:cd17352     9 FLVNFFTDGILNSFGVLFVELL---------EEFGESTSDIAWIGSLLLGV-----SLFSGPLSSALVNRF------GCR 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039747971 609 IIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCP-YALLGHY 659
Cdd:cd17352    69 PVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPaIVIVGQY 120
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
51-252 4.99e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971  51 RLWVMHGAVMFgrefCYAMETALVT--PILLQ--IGLPEKYYSLTWFLSPVLGLIFTPLIGSASDRctlsWGRRRPFILA 126
Cdd:COG2271   181 RFWLLALAYFL----VYFALYGFLTwlPTYLVevRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR----LGRRRKLVLA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 127 ---LCVGVLIGVALFLNGSAIGLALgdvpsrqpIGIVLtvlgvvvldFSADATEGPIRAYLLDVVDSEEQDMALNIHAFS 203
Cdd:COG2271   253 iglLLAALALLLLALLPSPALAIAL--------LFLAG---------FGLGGAFGLLWALAAELFPKKARGTASGLVNTF 315

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1039747971 204 AGLGGAIGYVLGGldwtqtFLGDWFQTqnQVLFFFAAVIFSVSVALHLF 252
Cdd:COG2271   316 GFLGGALGPLLVG------YLLDATGY--QAAFLLLAALALLAALLALL 356
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 528-744 5.04e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 528 LCLCHLLTWFSVIAEAVFYTDFMGQVIFkgnpqapSNSTkwhaynAGVKMGCWGLViYAATGAICSALLQKYldnydlSI 607
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGL-------SASQ------LGLLFALFSLG-YALLQPLAGLLADRF------GR 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039747971 608 RIIYMLGTLGFSVGTAVMAMFPNVYVAMVTISTMGVVSMSISYCPYALLGHYHDIKEyvhhspgnskrgFGIDCAILSCQ 687
Cdd:cd06174    61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE------------RGRALGLLQAF 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039747971 688 VYISQILVASALGGVVDAVNSIVVIPIVASVGSFLGFLTATFLVIYPEVSEEPKEEQ 744
Cdd:cd06174   129 GSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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