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Conserved domains on  [gi|1039733715|ref|XP_017169515|]
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N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 98-210 9.29e-23

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


:

Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 93.25  E-value: 9.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733715  98 NISLLPKEAQVRLSNLDLQLERGDITLKGYNLSKSALLRSFLGNSLDTkikpqartdeTKGNLEVPQENPSH--RRPHGf 175
Cdd:pfam06464   1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP----------TKLSAEAQNQLASLetKLRDE- 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039733715 176 AGEHRSERWTAPAETVTVKGRDHALNPPPVLETNA 210
Cdd:pfam06464  70 ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 516-572 1.25e-22

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465348  Cd Length: 55  Bit Score: 91.12  E-value: 1.25e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039733715 516 DDIRKNPRKFVCLNDNIDHNHKDArtVKAVLRDFYESMFPIPSQFELPREYRNRFLH 572
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE--VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 333-381 4.66e-19

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465347  Cd Length: 49  Bit Score: 80.64  E-value: 4.66e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039733715 333 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 381
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Name Accession Description Interval E-value
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 98-210 9.29e-23

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 93.25  E-value: 9.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733715  98 NISLLPKEAQVRLSNLDLQLERGDITLKGYNLSKSALLRSFLGNSLDTkikpqartdeTKGNLEVPQENPSH--RRPHGf 175
Cdd:pfam06464   1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP----------TKLSAEAQNQLASLetKLRDE- 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039733715 176 AGEHRSERWTAPAETVTVKGRDHALNPPPVLETNA 210
Cdd:pfam06464  70 ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 516-572 1.25e-22

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465348  Cd Length: 55  Bit Score: 91.12  E-value: 1.25e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039733715 516 DDIRKNPRKFVCLNDNIDHNHKDArtVKAVLRDFYESMFPIPSQFELPREYRNRFLH 572
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE--VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 333-381 4.66e-19

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 80.64  E-value: 4.66e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039733715 333 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 381
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Name Accession Description Interval E-value
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 98-210 9.29e-23

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 93.25  E-value: 9.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733715  98 NISLLPKEAQVRLSNLDLQLERGDITLKGYNLSKSALLRSFLGNSLDTkikpqartdeTKGNLEVPQENPSH--RRPHGf 175
Cdd:pfam06464   1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP----------TKLSAEAQNQLASLetKLRDE- 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039733715 176 AGEHRSERWTAPAETVTVKGRDHALNPPPVLETNA 210
Cdd:pfam06464  70 ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 516-572 1.25e-22

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465348  Cd Length: 55  Bit Score: 91.12  E-value: 1.25e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039733715 516 DDIRKNPRKFVCLNDNIDHNHKDArtVKAVLRDFYESMFPIPSQFELPREYRNRFLH 572
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE--VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 333-381 4.66e-19

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 80.64  E-value: 4.66e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039733715 333 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 381
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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