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Conserved domains on  [gi|1039794306|ref|XP_017169098|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-264 2.16e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 2.16e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 264
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 487-1310 1.23e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  487 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 559
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  560 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 639
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  640 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 715
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  716 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 795
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  796 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 856
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  857 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 916
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  917 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 981
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  982 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1061
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1062 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1141
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1142 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1221
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1222 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1290
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1039794306 1291 DKSLTTIMELQQRIQESAKQ 1310
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 295-620 6.58e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  295 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 374
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  375 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 454
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  455 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 531
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  532 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 611
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1039794306  612 RGRRVVELE 620
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-264 2.16e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 2.16e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 264
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 487-1310 1.23e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  487 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 559
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  560 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 639
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  640 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 715
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  716 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 795
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  796 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 856
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  857 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 916
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  917 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 981
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  982 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1061
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1062 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1141
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1142 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1221
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1222 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1290
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1039794306 1291 DKSLTTIMELQQRIQESAKQ 1310
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-199 2.52e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 2.52e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  107 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 186
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039794306  187 LLIDRGADVNSRD 199
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-218 9.57e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   50 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 125
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  126 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 203
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1039794306  204 TALMLGCEYGCRDAV 218
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
PTZ00121 PTZ00121
MAEBL; Provisional
 460-1283 2.58e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  460 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 537
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  538 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 615
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  616 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 695
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  696 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 775
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  776 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 853
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  854 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 931
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  932 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 1011
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1012 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1091
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1092 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1165
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1166 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1226
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1227 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1283
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 489-1316 9.62e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 76.70  E-value: 9.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  489 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 557
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  558 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 635
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  636 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 713
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  714 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 785
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  786 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 865
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  866 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 945
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  946 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1022
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1023 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1088
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1089 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1168
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1169 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1244
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1245 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1316
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1068-1411 2.02e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1147
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1224
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1225 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1304
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1305 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1384
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1039794306 1385 LLSAAQGHMDEDVQAALLQIIQMRQGL 1411
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 22-236 8.42e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 8.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   22 PTAVASTQSAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGID 95
Cdd:TIGR00870    3 PLDIVPAEESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   96 VATrdsaGRNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASV 162
Cdd:TIGR00870   79 GAV----GDTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  163 NAK----------DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY--------- 212
Cdd:TIGR00870  155 PARacgdffvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmyn 234

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039794306  213 -------GCRDAVEV-LVKNGADLTLLDALGH 236
Cdd:TIGR00870  235 falslldKLRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 78-206 4.82e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   78 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 149
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  150 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 295-620 6.58e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  295 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 374
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  375 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 454
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  455 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 531
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  532 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 611
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1039794306  612 RGRRVVELE 620
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-264 2.16e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 2.16e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 264
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-263 4.30e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.87  E-value: 4.30e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   31 AEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 110
Cdd:COG0666     15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  111 AKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLID 190
Cdd:COG0666     95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039794306  191 RGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNK 263
Cdd:COG0666    175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-237 8.87e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 8.87e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   40 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 119
Cdd:COG0666     91 LHAAARNGDLEIVK-LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  120 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 199
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039794306  200 KQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHD 237
Cdd:COG0666    250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-254 7.46e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.91  E-value: 7.46e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   55 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDL 134
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  135 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 214
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1039794306  215 RDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 254
Cdd:COG0666    166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 487-1310 1.23e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  487 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 559
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  560 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 639
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  640 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 715
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  716 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 795
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  796 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 856
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  857 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 916
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  917 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 981
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  982 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1061
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1062 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1141
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1142 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1221
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1222 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1290
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1039794306 1291 DKSLTTIMELQQRIQESAKQ 1310
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-206 1.18e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.03  E-value: 1.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   40 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 119
Cdd:COG0666    124 LHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  120 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 199
Cdd:COG0666    203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                   ....*..
gi 1039794306  200 KQNRTAL 206
Cdd:COG0666    283 LDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-199 2.52e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 2.52e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  107 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 186
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039794306  187 LLIDRGADVNSRD 199
Cdd:pfam12796   79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
86-254 2.55e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 2.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   86 LNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 165
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  166 DIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIG 245
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                   ....*....
gi 1039794306  246 DNLDILNLL 254
Cdd:COG0666    164 GNLEIVKLL 172
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-218 9.57e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   50 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 125
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  126 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 203
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1039794306  204 TALMLGCEYGCRDAV 218
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-166 1.82e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.82e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   74 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTehVDLQGRTALHDAAMADCPSSIQ 153
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039794306  154 LLCDHGASVNAKD 166
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 460-1283 2.58e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  460 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 537
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  538 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 615
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  616 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 695
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  696 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 775
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  776 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 853
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  854 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 931
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  932 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 1011
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1012 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1091
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1092 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1165
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1166 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1226
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1227 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1283
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
637-1223 4.98e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.51  E-value: 4.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  637 EKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKN 716
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKI 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  717 QTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKshdvnVEDLNKKLSEATQRYTEKKQEAERLLAendKL 796
Cdd:PRK03918   262 RELEERIEELKKEIEELEEKVKEL--------------KELKE-----KAEEYIKLSEFYEEYLDELREIEKRLS---RL 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  797 TKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkasl 876
Cdd:PRK03918   320 EEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL-EERHELYEEAKAKKEELERLKKRLT---------------- 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  877 NSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevlRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN-----A 951
Cdd:PRK03918   383 GLTPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKElleeyT 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  952 AILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklKYAPLARLEECERKFKATEKGLKEQLSEqthKCRQRDEEVKKGK 1031
Cdd:PRK03918   459 AELKRIEKELKEIEEKERKLRKELRELEKVLK----KESELIKLKELAEQLKELEEKLKKYNLE---ELEKKAEEYEKLK 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1032 QENERLRADLAALQKELQDRNALAEEAREAERalsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLL 1111
Cdd:PRK03918   532 EKLIKLKGEIKSLKKELEKLEELKKKLAELEK----KLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLEL 607

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1112 QKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQqllenQKNSSVTLAEHLKLKEALEKEVGIMKASL 1191
Cdd:PRK03918   608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELE-----KKYSEEEYEELREEYLELSRELAGLRAEL 682

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039794306 1192 REKEEESQKKTKEVSKLQTEVQTTKQALKNLE 1223
Cdd:PRK03918   683 EELEKRREEIKKTLEKLKEELEEREKAKKELE 714
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 545-1367 5.24e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.43  E-value: 5.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  545 IIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEfkRDEGRLVEENKRLQKECGTCEVELERRGRRVVE 618
Cdd:TIGR02169  192 IIDEKRQQLERLRRerekaeRYQALLKEKREYEGYELLKEKEALE--RQKEAIERQLASLEEELEKLTEEISELEKRLEE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  619 LEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEheqLRSRL 698
Cdd:TIGR02169  270 IEQLLEELNKKI------------KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEA---EIDKL 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  699 EQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRvseemkkshdvnveDLNKKLSEATQR 778
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELK--------------DYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  779 YTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELnkkcgegQEKIRALMSENSSLKKT 858
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNA----------AIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  859 LSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMkADYVSLEEH------ 932
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERyataie 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  933 ---SRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHaEIKAQKKELDTIQECIKLKYAplARLEECERKFKATEK-- 1007
Cdd:TIGR02169  543 vaaGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKYEPAFKyv 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1008 -----------------------GLKEQLSEQT-------HKCRQRDEEVKKGKQENERLRADLAALQKELQDrnalaee 1057
Cdd:TIGR02169  620 fgdtlvvedieaarrlmgkyrmvTLEGELFEKSgamtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSS------- 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1058 AREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE 1137
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1138 ElrskqrcLEREQQTVSQLQQLLENQKnssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1217
Cdd:TIGR02169  773 D-------LHKLEEALNDLEARLSHSR-----IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1218 ALKNLETRevvdmskykatKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIRDQKERcdksltti 1297
Cdd:TIGR02169  841 QRIDLKEQ-----------IKSIEKEIENLNGKKEELEEELEEL--EAALRDLESRLGDLKKERDELEAQLR-------- 899

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1298 mELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTySSGSPTKRQSQLVDTLQQRVRDLQQQL 1367
Cdd:TIGR02169  900 -ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK-GEDEEIPEEELSLEDVQAELQRVEEEI 967
Ank_2 pfam12796
Ankyrin repeats (3 copies);
140-232 9.10e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 9.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  140 LHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 219
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039794306  220 VLVKNGADLTLLD 232
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 633-1330 9.95e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.73  E-value: 9.95e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  633 SVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQ-----LKRDLESVRAQHIRPEEH----EQLRSRLEQKSG 703
Cdd:PTZ00121  1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARkaeeaKKKAEDARKAEEARKAEDarkaEEARKAEDAKRV 1154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  704 ELGKKVSELTLKNQTLQ-KDVEKLHADNKL--------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 774
Cdd:PTZ00121  1155 EIARKAEDARKAEEARKaEDAKKAEAARKAeevrkaeeLRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  775 ATQRYTE-KKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKkcgeGQEKIRAlmsenS 853
Cdd:PTZ00121  1235 AKKDAEEaKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKK----AEEKKKA-----D 1305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  854 SLKKtlssqyvpaKTHEEVKA-SLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 932
Cdd:PTZ00121  1306 EAKK---------KAEEAKKAdEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  933 SRRMSTVSQSLKEAQEANaailadhrqgqeeivslhaeiKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 1012
Cdd:PTZ00121  1377 KKKADAAKKKAEEKKKAD---------------------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE 1435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1013 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1092
Cdd:PTZ00121  1436 AKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEA 1515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1093 LVEEKAKQASEILAAQNllQKQPVPLEQVEALKKSlngtieqlkEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1172
Cdd:PTZ00121  1516 KKAEEAKKADEAKKAEE--AKKADEAKKAEEKKKA---------DELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAE 1584

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1173 HLKLKE--------ALEKEVGIMKASLREKEEESQKKTKEVSKlQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQI 1244
Cdd:PTZ00121  1585 EAKKAEearieevmKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1245 SNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEqeirdQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLND 1324
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE-----EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE 1738


                   ....*.
gi 1039794306 1325 VERLKQ 1330
Cdd:PTZ00121  1739 AEEDKK 1744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 651-1368 1.11e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 1.11e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  651 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH----------------------IRPEEHEQLRSRLEQKSGELGKK 708
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLERQAekaerykelkaelrelelallvLRLEELREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  709 VSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAER 788
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  789 LLAENDKLTKNVSRLEAVFVAP----EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS--- 861
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLeaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERled 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  862 ---------QYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL---ENVQNQMKADYVSL 929
Cdd:TIGR02168  415 rrerlqqeiEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALdaaERELAQLQARLDSL 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  930 EEHSRRMSTVSQSLKE--------------------------------------------AQEANAAI--LADHRQGQ-- 961
Cdd:TIGR02168  495 ERLQENLEGFSEGVKAllknqsglsgilgvlselisvdegyeaaieaalggrlqavvvenLNAAKKAIafLKQNELGRvt 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  962 --EEIVSLHAEIKAQKKELDTIQECIKlkyAPLARLEECERKFKATEKGL------KEQLSEQTHKCRQRDEEVKKGKQE 1033
Cdd:TIGR02168  575 flPLDSIKGTEIQGNDREILKNIEGFL---GVAKDLVKFDPKLRKALSYLlggvlvVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1034 NERLRADLAALQKE------LQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1107
Cdd:TIGR02168  652 GDLVRPGGVITGGSaktnssILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1108 QNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQ-------QTVSQLQQLLENQKNSSVTLAEHLKlkeAL 1180
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEeelaeaeAEIEELEAQIEQLKEELKALREALD---EL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1181 EKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtrevVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ 1260
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELIEELESELEALLNERAS 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1261 ACEEKVSAKDEKELLhlsiEQEIRDQKERcdkslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1340
Cdd:TIGR02168  885 LEEALALLRSELEEL----SEELRELESK-------RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL 953

                          810       820
                   ....*....|....*....|....*....
gi 1039794306 1341 SSGSPTKRQSQL-VDTLQQRVRDLQQQLA 1368
Cdd:TIGR02168  954 EEAEALENKIEDdEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 773-1376 1.38e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 1.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  773 SEATQRYTEKKQEAERLLAE--NDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 850
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAllVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  851 ENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLE 930
Cdd:TIGR02168  289 ELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  931 EHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK--LKYAPLARLEECERKFKATEKG 1008
Cdd:TIGR02168  369 ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELEELEEE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1009 LKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKS 1088
Cdd:TIGR02168  449 LEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1089 EREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNG------------------TIEQLKEELRSKQRC 1145
Cdd:TIGR02168  525 LSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQNELGrvtflpldsikgteiqgnDREILKNIEGFLGVA 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 LEREQQT----------------VSQLQQLLENQKNSS-----VTLAEHL------KLKEALEKEVGIM--KASLREKEE 1196
Cdd:TIGR02168  605 KDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyriVTLDGDLvrpggvITGGSAKTNSSILerRREIEELEE 684

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1197 ESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDKLASLNRK-------YDQACEEKVSAK 1269
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEE----ELEQLRKELEELSRQISALRKDLARLEAEveqleerIAQLSKELTELE 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1270 DEKELLHLSIEQEIRDQKERCDKslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQ 1349
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAE----IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660
                   ....*....|....*....|....*..
gi 1039794306 1350 SQLVDTLQQRVRDLQQQLADADRQHQE 1376
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEE 863
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 487-1300 5.34e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.96  E-value: 5.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  487 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH------FLALKEHLTNEAATGSHRIIEELREQLKDLKGKY 560
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRErekaerYQALLKEKREYEGYELLKEKEALERQKEAIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  561 EGASAEVGKLRSQIKQSEMLVGEF--------KRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLA- 631
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIeqlleelnKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAk 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  632 LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRP-EEHEQLRSRLEQksgeLGKKVS 710
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrDELKDYREKLEK----LKREIN 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  711 ELTLKNQTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQrytekkqEAERLL 790
Cdd:TIGR02169  403 ELKRELDRLQEELQRLSEELADLNAAIAGI--------------EAKINELEEEKEDKALEIKKQEW-------KLEQLA 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  791 AENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS------QYV 864
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEY---DRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQlgsvgeRYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  865 PAKtheEVKAS--LNSTVEKTNR------ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRrm 936
Cdd:TIGR02169  539 TAI---EVAAGnrLNNVVVEDDAvakeaiELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYE-- 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  937 STVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQ 1016
Cdd:TIGR02169  614 PAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSL 693

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1017 THKCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEE 1096
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIE-------QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEAR 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1097 KAKQASEILAAQNLLQK-----QPVPLEQVEALKKSLNGTIEQLKEELRSkqrcLEREQQTVSQLQQLLENQKNSSVTLA 1171
Cdd:TIGR02169  767 IEELEEDLHKLEEALNDlearlSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLNRLTLEKEYLEKEIQELQEQR 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1172 EHLKL-KEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDK 1250
Cdd:TIGR02169  843 IDLKEqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLRELERKIEELEAQIEKKRKR 918

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039794306 1251 LASLNRKYdQACEEKVSAKDEKELLHLSIEQE---IRDQKERCDKSLTTIMEL 1300
Cdd:TIGR02169  919 LSELKAKL-EALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRAL 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 735-1411 1.15e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.80  E-value: 1.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  735 QQVHSLTVEMKTRYVPL-RVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLlaeNDKLTKNVSRLEAvfvapekH 813
Cdd:TIGR02168  189 DRLEDILNELERQLKSLeRQAEKAERYKELKAELRELELALLVLRLEELREELEEL---QEELKEAEEELEE-------L 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  814 EKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKR 893
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQK-------QILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  894 FDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKA 973
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLER 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  974 QKKELDTIQECIK--LKYAPLARLEECERKFKATEKGLKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDR 1051
Cdd:TIGR02168  412 LEDRRERLQQEIEelLKKLEEAELKELQAELEELEEELEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQL 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1052 NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKK 1126
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQ 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1127 SLNG------------------TIEQLKEELRSKQRCLEREQQT----------------VSQLQQLLENQKNSS----- 1167
Cdd:TIGR02168  568 NELGrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyri 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1168 VTLAEHL-----------------------KLKEaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLET 1224
Cdd:TIGR02168  648 VTLDGDLvrpggvitggsaktnssilerrrEIEE-LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1225 REVVDMSKYKATKN----------DLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLhlsiEQEIRDQKERCDKSL 1294
Cdd:TIGR02168  727 QISALRKDLARLEAeveqleeriaQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL----EAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1295 TTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQH 1374
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ-------IEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1039794306 1375 QEVIAIYRT-----HLLSAAQGHMDEDVQAALLQIIQMRQGL 1411
Cdd:TIGR02168  876 EALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
764-1330 1.66e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.03  E-value: 1.66e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  764 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 843
Cdd:PRK03918   180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  844 KIRALMSENSSLKKTLssqyvpaKTHEEVKASLNStVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 923
Cdd:PRK03918   260 KIRELEERIEELKKEI-------EELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  924 adyvSLEEHSRRMSTVSQSLKEAQEANAAIladhrqgqEEIVSLHAEIKAQKKELDTIQECIKLKyaplaRLEECERKFK 1003
Cdd:PRK03918   332 ----ELEEKEERLEELKKKLKELEKRLEEL--------EERHELYEEAKAKKEELERLKKRLTGL-----TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1004 ATEKGlKEQLSEQTHKCRQRDEEVkkgKQENERLRADLAALQKE-----LQDRNALAEEAREAERALSGKADELSKQLKD 1078
Cdd:PRK03918   395 ELEKA-KEEIEEEISKITARIGEL---KKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELLEEYTAELKRIEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1079 LSQKYSDVKSEREKlVEEKAKQASEILAAQNLlqkqpvpLEQVEALKKSLNG-TIEQLK------EELRSKQRCLEREQQ 1151
Cdd:PRK03918   471 IEEKERKLRKELRE-LEKVLKKESELIKLKEL-------AEQLKELEEKLKKyNLEELEkkaeeyEKLKEKLIKLKGEIK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1152 TVSQLQQLLENQKNSSVTLAEHLK-LKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdm 1230
Cdd:PRK03918   543 SLKKELEKLEELKKKLAELEKKLDeLEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREE---- 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1231 SKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDE----KELLHLSIEQEI---RDQKERCDKSLTTIMELQQR 1303
Cdd:PRK03918   619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEeyeeLREEYLELSRELaglRAELEELEKRREEIKKTLEK 698

                          570       580       590
                   ....*....|....*....|....*....|
gi 1039794306 1304 IQESAKQIEAKDNKITEL---LNDVERLKQ 1330
Cdd:PRK03918   699 LKEELEEREKAKKELEKLekaLERVEELRE 728
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 349-1254 7.54e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.10  E-value: 7.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  349 ESEREKLKSLLAAKEKQHEESLRTIEALKNRfkyfesdhpgpgsypSNRKEDMLHKQGQMYTTEpqcaspgipphmHSRS 428
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEELKE---------------AEEELEELTAELQELEEK------------LEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  429 MLRPLELSlpsqtsyseneilkKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 508
Cdd:TIGR02168  273 RLEVSELE--------------EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  509 VQkrmyESEGKVKQMQTHFLALKEHLTNEAAT--GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR 586
Cdd:TIGR02168  339 LA----ELEEKLEELKEELESLEAELEELEAEleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  587 DEGRLVEENKRLQKEcgTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYES 666
Cdd:TIGR02168  415 RRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEEL------ERLEEALEELREELEEAEQALDAAERELAQ 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  667 AQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVS-----ELTLKNqTLQKDVEKLHADNK-LLNQQVHSL 740
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyEAAIEA-ALGGRLQAVVVENLnAAKKAIAFL 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  741 TVEMKTRYVPLRVSeemkkshDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS-RLEAVFVAPEkhekelmg 819
Cdd:TIGR02168  566 KQNELGRVTFLPLD-------SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyLLGGVLVVDD-------- 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  820 LKSNIAELKKQLSELNKKCGEGQekiralmsensslkkTLSSQYVPAKTHEEVKASLNStvekTNRALLEAKKRFDDTSQ 899
Cdd:TIGR02168  631 LDNALELAKKLRPGYRIVTLDGD---------------LVRPGGVITGGSAKTNSSILE----RRREIEELEEKIEELEE 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  900 EVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELD 979
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  980 TIQEciklkyaplaRLEECERKfkatekglKEQLSEQThkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAR 1059
Cdd:TIGR02168  772 EAEE----------ELAEAEAE--------IEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLE 830

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1060 EAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEEL 1139
Cdd:TIGR02168  831 RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1140 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEkevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQAL 1219
Cdd:TIGR02168  911 SELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT---------LEEAEALENKIEDDEEEARRRLKRLENKI 981

                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 1039794306 1220 KNLETREVVDMSKYKATK---NDLETQISNLNDKLASL 1254
Cdd:TIGR02168  982 KELGPVNLAAIEEYEELKeryDFLTAQKEDLTEAKETL 1019
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 77-229 2.06e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 78.37  E-value: 2.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   77 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLC 156
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039794306  157 dHGASVNAKDIDGRTpLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLT 229
Cdd:PLN03192   612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 48-196 2.26e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 2.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   48 DVEKVSSILAKKGVHPGKLDVEGRSAFHVVASK--GNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHA------LCL 119
Cdd:PHA03100    84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  120 QK------------LLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 187
Cdd:PHA03100   164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                   ....*....
gi 1039794306  188 LIDRGADVN 196
Cdd:PHA03100   244 LLNNGPSIK 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 698-1326 4.57e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 77.37  E-value: 4.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  698 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKtryvplrvseEMKKSHDVNVEDLNKKLSEatq 777
Cdd:TIGR04523   80 LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELN----------KLEKQKKENKKNIDKFLTE--- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  778 rYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIralmsensSLKK 857
Cdd:TIGR04523  147 -IKKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKI--------QKNK 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  858 TLSSQYVPAKtheEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkadyvsLEEHSRRMS 937
Cdd:TIGR04523  215 SLESQISELK---KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKE-------LEQNNKKIK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  938 TVSqslKEAQEANAAILADHRQGQEEIVS-LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGL------- 1009
Cdd:TIGR04523  285 ELE---KQLNQLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSesensek 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1010 KEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSE 1089
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1090 REKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclereqqtVSQLQQLLENQKNSSVT 1169
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK----------EKELKKLNEEKKELEEK 511

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1170 LAEhlklkeaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-----MSKYKATKNDLEtqi 1244
Cdd:TIGR04523  512 VKD-------LTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLK--- 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1245 sNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQ---QRIQESAKQIEAKDNKITEL 1321
Cdd:TIGR04523  582 -KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNK 660


                   ....*
gi 1039794306 1322 LNDVE 1326
Cdd:TIGR04523  661 WPEII 665
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 489-1316 9.62e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 76.70  E-value: 9.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  489 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 557
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  558 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 635
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  636 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 713
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  714 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 785
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  786 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 865
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  866 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 945
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  946 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1022
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1023 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1088
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1089 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1168
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1169 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1244
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1245 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1316
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
449-1039 1.13e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  449 LKKELETLRTYYDSAKQdRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ---- 524
Cdd:PRK03918   212 ISSELPELREELEKLEK-EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelke 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  525 --THFLALKEhLTNEAATGSHRI----------IEELREQLKDLKGKyegaSAEVGKLRSQIKQSEMLVGEFKRDEgRLV 592
Cdd:PRK03918   291 kaEEYIKLSE-FYEEYLDELREIekrlsrleeeINGIEERIKELEEK----EERLEELKKKLKELEKRLEELEERH-ELY 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  593 EENKRLQKECGtcEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVgrdyESAQGEI 671
Cdd:PRK03918   365 EEAKAKKEELE--RLKKRLTGLTPEKLEKELEELeKAKEEIEEEISKITARIGELKKEIKELKKAIEEL----KKAKGKC 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  672 RQLKRDLESvraqhirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhaDNKLLNQqvhSLTVEMKTRYVPL 751
Cdd:PRK03918   439 PVCGRELTE--------EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKE---SELIKLKELAEQL 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  752 RVSEEMKKSHDVnvedlnKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQL 831
Cdd:PRK03918   506 KELEEKLKKYNL------EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL-------KKKLAELEKKLDELEEEL 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  832 SELNKKCGE-GQEKIRALMSENSSLKKtLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEV 910
Cdd:PRK03918   573 AELLKELEElGFESVEELEERLKELEP-FYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  911 LRRNLEnvqnqmKADYVSLEEHSRRMSTVSQSLKEAQEAnaaiLADHRqgqEEIVSLHAEIKAQKKELDTIQECIKLKYA 990
Cdd:PRK03918   652 LEKKYS------EEEYEELREEYLELSRELAGLRAELEE----LEKRR---EEIKKTLEKLKEELEEREKAKKELEKLEK 718

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039794306  991 PLARLEECERKFKATEKGLKEQ-LSEQTHKCRQRDEEVKKGKQENERLRA 1039
Cdd:PRK03918   719 ALERVEELREKVKKYKALLKERaLSKVGEIASEIFEELTEGKYSGVRVKA 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 778-1376 1.76e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 1.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  778 RYTEKKQEAERLLAENDKltkNVSRLEAVfvapekhekelmglksnIAELKKQLSELNKKcGEGQEKIRALMSENSSLKK 857
Cdd:TIGR02168  169 KYKERRKETERKLERTRE---NLDRLEDI-----------------LNELERQLKSLERQ-AEKAERYKELKAELRELEL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  858 TLSS-QYVPAKTH----EEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 932
Cdd:TIGR02168  228 ALLVlRLEELREEleelQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  933 SRRMSTVSQSLKEAQEanaaILADHRQGQEEivsLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 1012
Cdd:TIGR02168  308 RERLANLERQLEELEA----QLEELESKLDE---LAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1013 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1092
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1093 LVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS-KQRCLEREQ--QTVSQLQQLLENQKN---- 1165
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvKALLKNQSGlsGILGVLSELISVDEGyeaa 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1166 SSVTLAEHL-----KLKEALEKEVGIMKASLREKE---EESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1237
Cdd:TIGR02168  539 IEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVtflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1238 NDL------ETQISNLNDKLASLNRKY-------DQACEEKVSAK--DEKELLHLSIEQEIRDQKERCDkslttimELQQ 1302
Cdd:TIGR02168  619 SYLlggvlvVDDLDNALELAKKLRPGYrivtldgDLVRPGGVITGgsAKTNSSILERRREIEELEEKIE-------ELEE 691

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039794306 1303 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1376
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 89-228 2.12e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 2.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   89 ILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCP-SSIQLLCDHGASVNAKDI 167
Cdd:PHA02876   361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794306  168 DGRTPLVLATQM-CRPTICQLLIDRGADVNSRDKQNRTALMLGCEYgcRDAVEVLVKNGADL 228
Cdd:PHA02876   441 DLSTPLHYACKKnCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 496-1299 2.54e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 75.06  E-value: 2.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  496 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSHRIIEELREQLKDLKGKyegasaevgklrsqIK 575
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN-----SNNKIKILEQQIKDLNDK--------------LK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  576 QSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQLKELGAKLAL-SVPTEKFESMKSSLSNDINEKV 654
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNK-------LEKQKKENKKNIDKfLTEIKKKEKELEKLNNKYNDLK 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  655 KRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLN 734
Cdd:TIGR04523  166 KQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKT 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  735 QQVHSLTVEMKTryvplrvseeMKKSHDVNVEDLNKKLSEATQryTEKKqeaerllaeNDKLTKNVSRLEAVFVA--PEK 812
Cdd:TIGR04523  246 TEISNTQTQLNQ----------LKDEQNKIKKQLSEKQKELEQ--NNKK---------IKELEKQLNQLKSEISDlnNQK 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  813 HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkaSLNSTVEKTNRALLEAKk 892
Cdd:TIGR04523  305 EQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT--------------NSESENSEKQRELEEKQ- 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  893 rfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaailaDHRQGQEEIVSLHAEIK 972
Cdd:TIGR04523  370 ------NEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ-------EKELLEKEIERLKETII 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  973 AQKKELDTIQECIklkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1052
Cdd:TIGR04523  437 KNNSEIKDLTNQD-------SVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK--- 506

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1053 alaeeareaeralsgkadELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL--EQVEALKKSLNG 1130
Cdd:TIGR04523  507 ------------------ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNK 568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1131 TIEQLKEElrskQRCLEREQQTVSQL-QQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1209
Cdd:TIGR04523  569 EIEELKQT----QKSLKKKQEEKQELiDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1210 TEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELL--HLSIEQEIRDQK 1287
Cdd:TIGR04523  645 QEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLPKLEekYKEIEKELKKLD 724

                          810
                   ....*....|..
gi 1039794306 1288 ErCDKSLTTIME 1299
Cdd:TIGR04523  725 E-FSKELENIIK 735
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 40-263 3.85e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.46  E-value: 3.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   40 LMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 119
Cdd:PHA02874   128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  120 QKLLQYncpTEHVDLQ---GRTALHDAAMADcPSSIQLLCDHgASVNAKDIDGRTPLVLATQM-CRPTICQLLIDRGADV 195
Cdd:PHA02874   207 KLLIDH---GNHIMNKcknGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPpCDIDIIDILLYHKADI 281

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306  196 NSRDKQNRTALMLGCEYGCRDAV-------EVLVKNGADLTLLDALGHDSsyyarIGDNLDILNLLKTASENTNK 263
Cdd:PHA02874   282 SIKDNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 302-1048 3.90e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.71  E-value: 3.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  302 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEevmvaddLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK 381
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEE-------LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  382 YFesdhpgpgsypsNRKEDMLHKQGQMYTTEpqcaspgipphmhsrsmlrplelslpSQTSYSENEILKKELETLRTYYD 461
Cdd:TIGR02168  306 IL------------RERLANLERQLEELEAQ--------------------------LEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  462 SAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATG 541
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  542 S--------------HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQkecgTCEV 607
Cdd:TIGR02168  424 EellkkleeaelkelQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE----RLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  608 ELERRGRRVVELEGQLKELGAKLA-----LSVPtEKFE-SMKSSLSNDINekvkrlAEVGRDYESAQGEIRQLKRD---- 677
Cdd:TIGR02168  500 NLEGFSEGVKALLKNQSGLSGILGvlselISVD-EGYEaAIEAALGGRLQ------AVVVENLNAAKKAIAFLKQNelgr 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  678 -----LESVRAQHIRPEEHEQLRS---------RLEQKSGELGKKVSELtLKNQTLQKDVEKLHADNKLLNQQVHSLTVE 743
Cdd:TIGR02168  573 vtflpLDSIKGTEIQGNDREILKNiegflgvakDLVKFDPKLRKALSYL-LGGVLVVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  744 ---MKTRYVPLRVSEEMKKS---HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvAPEKHEKEL 817
Cdd:TIGR02168  652 gdlVRPGGVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK---ELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  818 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDT 897
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  898 SQEVSKLRDENEVLRRNLENVQNQMkadyvslEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKE 977
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRI-------AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNE 881

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  978 LDTIQEciklkyaPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1048
Cdd:TIGR02168  882 RASLEE-------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-254 5.88e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 5.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   44 AERGDVEKVSSILAKKGvhpgklDVE-----GRSAFHVVASKGN---LECLNAILTHGIDVATRDSAGRNALHLAAKYGH 115
Cdd:PHA03095    22 ASNVTVEEVRRLLAAGA------DVNfrgeyGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  116 ALCLQKLL-QYNCPTEHVDLQGRTALHDAAMADC--PSSIQLLCDHGASVNAKDIDGRTPL--VLATQMCRPTICQLLID 190
Cdd:PHA03095    96 TLDVIKLLiKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLID 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  191 RGADVNSRDKQNRTALMLGCEYgCRD---AVEVLVKNGADLTLLDALGHDSSYYARIGD---NLDILNLL 254
Cdd:PHA03095   176 AGADVYAVDDRFRSLLHHHLQS-FKPrarIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 440-1215 8.20e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 73.61  E-value: 8.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  440 QTSYSENEILKKELETLRTYYDSAKQDrlkFQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGK 519
Cdd:pfam15921  116 QTKLQEMQMERDAMADIRRRESQSQED---LRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGV 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  520 VKQMQTHFLALKE---------------HLTNeAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGE 583
Cdd:pfam15921  186 LQEIRSILVDFEEasgkkiyehdsmstmHFRS-LGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKiELLLQQ 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  584 FKRDEGRLVEENKrlqkecgtcevelerrgrrvVELEGQlkelgaklalsvpTEKFESMKSSlSNDINEKVKRLAEVGRD 663
Cdd:pfam15921  265 HQDRIEQLISEHE--------------------VEITGL-------------TEKASSARSQ-ANSIQSQLEIIQEQARN 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  664 YESAQgeIRQLKrDLESVRAQhIRPEEHEQLRSrLEQKSGELGKkvsELTLKNQTL---QKDVEKLHADNKLLNQQVHSL 740
Cdd:pfam15921  311 QNSMY--MRQLS-DLESTVSQ-LRSELREAKRM-YEDKIEELEK---QLVLANSELteaRTERDQFSQESGNLDDQLQKL 382

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  741 TVEMKTRYVPLRVSEEMkkshdvnvedlNKKLSEatqRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPE-----KHEK 815
Cdd:pfam15921  383 LADLHKREKELSLEKEQ-----------NKRLWD---RDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKsecqgQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  816 ELMGLKSNIAELKKqLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpAKTHEEVKASLNS---TVEKTNRALLEAKK 892
Cdd:pfam15921  449 QMAAIQGKNESLEK-VSSLTAQLESTKEMLRKVVEELTAKKMTLESS---ERTVSDLTASLQEkerAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  893 RFDDTSQEVSKLRDENEVLRrnleNVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIK 972
Cdd:pfam15921  525 RVDLKLQELQHLKNEGDHLR----NVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  973 AQKKELdtiQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQrdeeVKKGKQENERLRADLAALQKELQDRN 1052
Cdd:pfam15921  601 DRRLEL---QEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA----VKDIKQERDQLLNEVKTSRNELNSLS 673

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1053 ALAEEAREAERALSGKADELSKQLK-DLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNgT 1131
Cdd:pfam15921  674 EDYEVLKRNFRNKSEEMETTTNKLKmQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ-F 752

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1132 IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-----SVTLAEHLKLKEALEK-EVGIMKASLREKEEESQKKTKEV 1205
Cdd:pfam15921  753 LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKmagelEVLRSQERRLKEKVANmEVALDKASLQFAECQDIIQRQEQ 832

                          810
                   ....*....|
gi 1039794306 1206 SKLQTEVQTT 1215
Cdd:pfam15921  833 ESVRLKLQHT 842
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 9.69e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 9.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   40 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIdvATRDSAGRNALHLAAKYGHALCL 119
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                   ....*...
gi 1039794306  120 QKLLQYNC 127
Cdd:pfam12796   78 KLLLEKGA 85
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
498-1173 1.43e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.40  E-value: 1.43e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  498 QIKQLEDALKDVQKRMYESEGKVKQMQThFLALKEHLTNEAATGSHRIIEELREqLKDLKGKYEGASAEVGKLRSQIKQS 577
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEK-FIKRTENIEELIKEKEKELEEVLRE-INEISSELPELREELEKLEKEVKEL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  578 EMLVGEFKRdegrLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELgaklalsvpTEKFESMKSslsndINEKVKRL 657
Cdd:PRK03918   234 EELKEEIEE----LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL---------EEKVKELKE-----LKEKAEEY 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  658 AEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSEltlknqtLQKDVEKLHADNKLLnQQV 737
Cdd:PRK03918   296 IKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE-------LEKRLEELEERHELY-EEA 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  738 HSLTVEMKtryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAendkltknvsrleavfvapekhekEL 817
Cdd:PRK03918   368 KAKKEELE---------RLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITA------------------------RI 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  818 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENsslKKTLSSQYvpaktHEEVKaSLNSTVEKTNRALLEAKKRFddt 897
Cdd:PRK03918   415 GELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH---RKELLEEY-----TAELK-RIEKELKEIEEKERKLRKEL--- 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  898 sQEVSKLRDENEVLRRNLEnVQNQMKADYVSLEEHsrrmstvsqSLKEAQEANaailADHRQGQEEIVSLHAEIKAQKKE 977
Cdd:PRK03918   483 -RELEKVLKKESELIKLKE-LAEQLKELEEKLKKY---------NLEELEKKA----EEYEKLKEKLIKLKGEIKSLKKE 547

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  978 LDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLR---ADLAALQKELQDRNAL 1054
Cdd:PRK03918   548 LEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEE 627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1055 AEEAREAERALSGKADELSKQLKDLSQKYSDvkSEREKLVEEKAKQASEILAAQNllqkqpvPLEQVEALKKSLNGTIEQ 1134
Cdd:PRK03918   628 LDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRA-------ELEELEKRREEIKKTLEK 698

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1039794306 1135 LKEEL---RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH 1173
Cdd:PRK03918   699 LKEELeerEKAKKELEKLEKALERVEELREKVKKYKALLKER 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1068-1411 2.02e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1147
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1224
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1225 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1304
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1305 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1384
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1039794306 1385 LLSAAQGHMDEDVQAALLQIIQMRQGL 1411
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 444-1292 5.40e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.87  E-value: 5.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  444 SENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQL-EDALKDVQKRMYESEGKVKQ 522
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEI----EQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIAS 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  523 MQthflalkehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEC 602
Cdd:TIGR02169  306 LE-------------------RSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  603 GTCEVELERRGRRVVELEGQLKELGAKL---------------ALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESA 667
Cdd:TIGR02169  367 EDLRAELEEVDKEFAETRDELKDYREKLeklkreinelkreldRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  668 QGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELtlknqtlqkdvEKLHADNKLLNQQVHSltvemkt 746
Cdd:TIGR02169  447 ALEIKKQEWKLEQLAADLSKYEqELYDLKEEYDRVEKELSKLQREL-----------AEAEAQARASEERVRG------- 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  747 ryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYtekkQEAERLLAENdkltknvsRLEAVFVAPEKHEKELmglksnIAE 826
Cdd:TIGR02169  509 ----GRAVEEVLKASIQGVHGTVAQLGSVGERY----ATAIEVAAGN--------RLNNVVVEDDAVAKEA------IEL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  827 LKKqlselnKKCGEGQ----EKIRALMSENSSLKK-----------TLSSQYVPAktheeVKASLNSTVEKTNralLEAK 891
Cdd:TIGR02169  567 LKR------RKAGRATflplNKMRDERRDLSILSEdgvigfavdlvEFDPKYEPA-----FKYVFGDTLVVED---IEAA 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  892 KRFDDTSQEVSKlrdENEVLRRN-----LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaAILADHRQGQEEIVS 966
Cdd:TIGR02169  633 RRLMGKYRMVTL---EGELFEKSgamtgGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS---SLQSELRRIENRLDE 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  967 LHAEIKAQKKELDTIQeciklkyAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQK 1046
Cdd:TIGR02169  707 LSQELSDASRKIGEIE-------KEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1047 ELQDrnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQpvplEQVEALKK 1126
Cdd:TIGR02169  780 ALND--LEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI---QELQEQR----IDLKEQIK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1127 SLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVS 1206
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK----------KERDELEAQLRELERKIEELEAQIEKKRKRLS 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1207 KLQTEVQTTKQALKNLE---------TREVVDMSKYKATKNDLETQISnlndKLASLNRKYDQACEEKVSAKDEKELLHL 1277
Cdd:TIGR02169  921 ELKAKLEALEEELSEIEdpkgedeeiPEEELSLEDVQAELQRVEEEIR----ALEPVNMLAIQEYEEVLKRLDELKEKRA 996

                          890
                   ....*....|....*
gi 1039794306 1278 SIEQEIRDQKERCDK 1292
Cdd:TIGR02169  997 KLEEERKAILERIEE 1011
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-247 5.83e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 5.83e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   47 GDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGN-LECLNAILTHGIDVATRDSAGRNALH--LAAKYGHALCLQKLL 123
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  124 QYNCPTEHVDLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRP--TICQLLIDRGADV 195
Cdd:PHA03095   140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDP 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306  196 NSRDKQNRTALMLGCEYG-CRDA-VEVLVKNGADLTLLDALGHDSSYYARIGDN 247
Cdd:PHA03095   216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 74-254 7.09e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 7.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   74 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHVDLQGRTALHDAAMADC 148
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  149 --PSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPT--ICQLLIDRGAD----------------VNSRDKQNRTALML 208
Cdd:PHA03100   119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDinaknrvnyllsygvpINIKDVYGFTPLHY 198

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1039794306  209 GCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 254
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 546-903 7.35e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 7.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  546 IEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDE-------GRLVEENKRLQKECGTCEVELERRGRRVVE 618
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELeelsrqiSALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  619 LEGQLKELGAKLALSVPTEK-FESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAqhiRPEEHEQLRSR 697
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAeAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE---RLESLERRIAA 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  698 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQ 777
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRR 915

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  778 RYTEKKQEAERLLAENDKLTKNVSRLEAVFvaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL-------MS 850
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQERL--SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgpvnlaaIE 993

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306  851 ENSSLKK---TLSSQYVPAkthEEVKASLNSTVEKTNRallEAKKRFDDTSQEVSK 903
Cdd:TIGR02168  994 EYEELKErydFLTAQKEDL---TEAKETLEEAIEEIDR---EARERFKDTFDQVNE 1043
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 50-237 7.93e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 7.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   50 EKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPT 129
Cdd:PHA02874   105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  130 EHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTIcQLLIDrGADVNSRDKQNRTALMLG 209
Cdd:PHA02874   184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                          170       180
                   ....*....|....*....|....*....
gi 1039794306  210 CEYGC-RDAVEVLVKNGADLTLLDALGHD 237
Cdd:PHA02874   262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 778-1368 1.07e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  778 RYTEKKQEAERLLAE--------NDK---LTKNVSRLE--------AVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 838
Cdd:COG1196    169 KYKERKEEAERKLEAteenlerlEDIlgeLERQLEPLErqaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  839 GEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 918
Cdd:COG1196    249 EELEAELEELEAELAELEAELEEL-------RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  919 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplARLEEc 998
Cdd:COG1196    322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE---------ELLEA- 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  999 erkfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKD 1078
Cdd:COG1196    392 ----LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1079 LSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQV-EALKKSLNGTIEQLKEELRSKQRCLE---------- 1147
Cdd:COG1196    468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVkAALLLAGLRGLAGAVAVLIGVEAAYEaaleaalaaa 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 ------REQQTVSQLQQLLENQKNSSVTLAEHLKLK-----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1216
Cdd:COG1196    548 lqnivvEDDEVAAAAIEYLKAAKAGRATFLPLDKIRaraalAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTL 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1217 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKydQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTT 1296
Cdd:COG1196    628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR--ELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794306 1297 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1368
Cdd:COG1196    706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 545-1141 3.90e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 3.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  545 IIEELREQLKDLKG------KYEGASAEVGKLRSQ-----IKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRG 613
Cdd:COG1196    194 ILGELERQLEPLERqaekaeRYRELKEELKELEAEllllkLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  614 RRVVELEGQLKELGAKLALSvptekfESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQ 693
Cdd:COG1196    274 LELEELELELEEAQAEEYEL------LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE------EELEE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  694 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLS 773
Cdd:COG1196    342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  774 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgEGQEKIRALMSENS 853
Cdd:COG1196    422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE--LAEAAARLLLLLEA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  854 SLKKTLSSQYVPAKTHEEVKASLNSTVektnrALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkADYVSLEEHS 933
Cdd:COG1196    500 EADYEGFLEGVKAALLLAGLRGLAGAV-----AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAA--IEYLKAAKAG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  934 RRmsTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQL 1013
Cdd:COG1196    573 RA--TFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVT 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1014 SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL 1093
Cdd:COG1196    651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1039794306 1094 VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1141
Cdd:COG1196    731 EAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-231 4.77e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.55  E-value: 4.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   48 DVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGI---DVATRDsaGRNALHLAAKYGHALCLQKLLQ 124
Cdd:PHA02875    47 DSEAIK-LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIA 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  125 YNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRT 204
Cdd:PHA02875   124 RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCV 203

                          170       180
                   ....*....|....*....|....*...
gi 1039794306  205 ALM-LGCEYGCRDAVEVLVKNGADLTLL 231
Cdd:PHA02875   204 AALcYAIENNKIDIVRLFIKRGADCNIM 231
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-274 7.54e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.63  E-value: 7.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   39 RLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALC 118
Cdd:PHA02876   147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  119 LQKLLQYNCPTEHVDLQGRTALHDaamADCPSSIqLLCDHGASVNAKDIDGRTPLVLATQMcrPTICQL---LIDRGADV 195
Cdd:PHA02876   227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  196 NSRDKQNRTALMLGCEYGC-RDAVEVLVKNGADLTLLDALGHDSSYYARIGD-NLDILNLLKTASENTNkggGRELWRKG 273
Cdd:PHA02876   301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN---ARDYCDKT 377


                   .
gi 1039794306  274 P 274
Cdd:PHA02876   378 P 378
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 82-242 2.09e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   82 NLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGAS 161
Cdd:PHA02874   103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  162 VNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLVKNgADLTLLDALGHDSSYY 241
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                   .
gi 1039794306  242 A 242
Cdd:PHA02874   261 A 261
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
881-1377 3.79e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.68  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  881 EKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 959
Cdd:PRK02224   169 ERASDARLGVERVLSDQRGSLDQLKAQiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEE 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  960 GQEEIVSLHAEIKaqkKELDTIQECIKLKYAplarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1039
Cdd:PRK02224   249 RREELETLEAEIE---DLRETIAETEREREE----LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELED 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1040 DLAALQKEL-------QDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ 1112
Cdd:PRK02224   322 RDEELRDRLeecrvaaQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1113 KQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK----NSSVTLAEHLKLKEALEKEVGIMK 1188
Cdd:PRK02224   402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRERVEELE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1189 ASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD--MSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV 1266
Cdd:PRK02224   482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEelIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1267 SAKDEKEllhlsieqEIRDQKERCDKSLTtimELQQRIqESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSS---- 1342
Cdd:PRK02224   562 EAEEEAE--------EAREEVAELNSKLA---ELKERI-ESLERIRTLLAAIADAEDEIERLREKREALAELNDERrerl 629

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1039794306 1343 GSPTKRQSQLVDTLQQ-RVRDLQQQLADADRQHQEV 1377
Cdd:PRK02224   630 AEKRERKRELEAEFDEaRIEEAREDKERAEEYLEQV 665
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 443-1323 4.68e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 4.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  443 YSENEILKKELETLRTYYDSAKQ----DRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 518
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAEliidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  519 KVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRL 598
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  599 QKEcgtcEVELERRGRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL 678
Cdd:pfam02463  324 KKA----EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELEL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  679 ESVRAQHIRPEEHeqlrsRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEmktryvplrvsEEMK 758
Cdd:pfam02463  400 KSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELK-----------LLKD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  759 KSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 838
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  839 GEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 918
Cdd:pfam02463  544 AISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  919 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEeiVSLHAEIKAQKKELDTIQECIKLKYAPLARLEEC 998
Cdd:pfam02463  624 VVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKAS--LSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  999 ERKFKATEKGLKEQLSEQTH-KCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeeaREAERALSGKADELSKQLK 1077
Cdd:pfam02463  702 KKKEQREKEELKKLKLEAEElLADRVQEAQDKINEELKLLKQKIDEEEEEEE---------KSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1078 DLSQKYSDVKSEREKLVEEKAKQaseILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ 1157
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEEKEEK---LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1158 QLLENQKNSSV-TLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKAT 1236
Cdd:pfam02463  850 KLAEEELERLEeEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1237 KNDLETQISNL----NDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1312
Cdd:pfam02463  930 LLKYEEEPEELlleeADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009

                          890
                   ....*....|.
gi 1039794306 1313 AKDNKITELLN 1323
Cdd:pfam02463 1010 AIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 450-806 6.46e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 6.46e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  450 KKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTHFLA 529
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQLSK 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  530 LKEHLTNEAATGSHRIIE------ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECG 603
Cdd:TIGR02168  755 ELTELEAEIEELEERLEEaeeelaEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  604 TCEVELERRGRRVVELEGQLKELGAKLAlsvptekfesmksSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 683
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIE-------------ELEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  684 QHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHAdnKLLNQqvHSLTVEMKTRYVPLRVSEEMKKSHDv 763
Cdd:TIGR02168  902 EL---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE--RLSEE--YSLTLEEAEALENKIEDDEEEARRR- 973

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039794306  764 nVEDLNKKLSE-------ATQRYTEKKQEAERLLAENDKLTKNVSRLEAV 806
Cdd:TIGR02168  974 -LKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
767-1330 7.41e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.91  E-value: 7.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  767 DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELkkqlselnkkcgegQEKIR 846
Cdd:PRK02224   203 DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDL--------------RETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  847 ALMSENSSLKKTLSSQyvpAKTHEEVKASLNSTVEKTNRALLEAkkrfDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 926
Cdd:PRK02224   269 ETEREREELAEEVRDL---RERLEELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  927 VSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATE 1006
Cdd:PRK02224   342 EEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1007 KGLKEQLSEQTHKCRQRDEEVkkgkQENERLRAdlaalqkelqdrnalaeeareaeralSGKADELSKQLKDlsqkysdv 1086
Cdd:PRK02224   422 DELREREAELEATLRTARERV----EEAEALLE--------------------------AGKCPECGQPVEG-------- 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1087 kSEREKLVEEKAKQASEILAAqnllqkqpvpLEQVEALKKSLNGTIEQLkEELRSKQRCLEREQQTVSQLQQLLENQKNS 1166
Cdd:PRK02224   464 -SPHVETIEEDRERVEELEAE----------LEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRET 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1167 ----SVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykATKNDLET 1242
Cdd:PRK02224   532 ieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLL-----AAIADAED 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1243 QISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE----QEIRDQKERCDKSLTTIMELQQRIQES----AKQIEAK 1314
Cdd:PRK02224   607 EIERLREKREALAELNDERRERLAEKRERKRELEAEFDeariEEAREDKERAEEYLEQVEEKLDELREErddlQAEIGAV 686

                          570
                   ....*....|....*.
gi 1039794306 1315 DNKITELLNDVERLKQ 1330
Cdd:PRK02224   687 ENELEELEELRERREA 702
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 783-1337 8.94e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.60  E-value: 8.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  783 KQEAERLLAENDKLTKNVSRleAVFVAPEKHEKELMGLKSNIAELKKQLSELN----------KKCGEGQEKIRalmsen 852
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirRRESQSQEDLR------ 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  853 SSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLE-------------------AKKRFDDTSQEVSKLRDENEVLRR 913
Cdd:pfam15921  145 NQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLShegvlqeirsilvdfeeasGKKIYEHDSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  914 NLENVQNQ---MKADYVSLEEHSRRMSTVSQS-----LKEAQEANAAILADHrqgQEEIVSLHAEIKAQKKELDTIQeci 985
Cdd:pfam15921  225 ILRELDTEisyLKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQ--- 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  986 klkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERlraDLAALQKELQDRNALAEEAREAERAL 1065
Cdd:pfam15921  299 -------SQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED---KIEELEKQLVLANSELTEARTERDQF 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1066 SGKA----DELSKQLKDLSQKYSDVKSERE---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSL----NGTIEQ 1134
Cdd:pfam15921  369 SQESgnldDQLQKLLADLHKREKELSLEKEqnkRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMksecQGQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1135 LKEELRSKQRCLEReqqtVSQLQQLLENQKNSSVTLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQT 1210
Cdd:pfam15921  449 QMAAIQGKNESLEK----VSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1211 EVQTTKQALKNLETRE--------VVDMSKYKATKND-----LETQISNLNDKLASLNRKYDQACEEKvsAKDEKELLHL 1277
Cdd:pfam15921  525 RVDLKLQELQHLKNEGdhlrnvqtECEALKLQMAEKDkvieiLRQQIENMTQLVGQHGRTAGAMQVEK--AQLEKEINDR 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306 1278 SIE-QEIRDQKercDKSLTTIMELQQRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ 1337
Cdd:pfam15921  603 RLElQEFKILK---DKKDAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSE 674
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 638-1380 2.93e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 2.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  638 KFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpeehEQLRSRLEQKSGELGKKvseltLKNQ 717
Cdd:TIGR02169  146 DFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLII------DEKRQQLERLRREREKA-----ERYQ 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  718 TLQKDVEKLHADNKLLNQQVHsltvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLT 797
Cdd:TIGR02169  215 ALLKEKREYEGYELLKEKEAL----------------ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  798 KNVSRL---EAVFVAPEKHE--KELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEV 872
Cdd:TIGR02169  279 KKIKDLgeeEQLRVKEKIGEleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  873 KASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLenvqNQMKADYVSLEEHSRRMstvSQSLKEAQEANAA 952
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI----NELKRELDRLQEELQRL---SEELADLNAAIAG 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  953 ILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQ 1032
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1033 ENERLRADLAALQKELQDRNALAEEAREAERALSG---------------KADELSKQLK-------------------- 1077
Cdd:TIGR02169  512 VEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGnrlnnvvveddavakEAIELLKRRKagratflplnkmrderrdls 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1078 ---------------DLSQKY--------------SDVKSEREKLVE-----------EKA--------KQASEILAAQN 1109
Cdd:TIGR02169  592 ilsedgvigfavdlvEFDPKYepafkyvfgdtlvvEDIEAARRLMGKyrmvtlegelfEKSgamtggsrAPRGGILFSRS 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1110 LLQKQPVPLEQVEALKKSLNG------TIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLK-EALEK 1182
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSlqselrRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDlSSLEQ 751

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1183 EVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-MSKYKATKNDLETQISNLNDKLASLNRKYDQA 1261
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAeLSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1262 CEEKVSAKDEKELLhlsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYS 1341
Cdd:TIGR02169  832 EKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1039794306 1342 SGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAI 1380
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 689-1366 3.15e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.91  E-value: 3.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  689 EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDveklhadnklLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDL 768
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC----------TPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  769 NKKLSEATQRyTEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL 848
Cdd:TIGR00618  246 TQKREAQEEQ-LKKQQLLKQLRARIEELRAQEAVLEE-----TQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  849 MSENSSLKKTLSSQYVPAKTHEEVKASLNStvektnraLLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQnQMKADYVS 928
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISCQQHTLTQHIH-TLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  929 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKY----APLARLEECERKFKA 1004
Cdd:TIGR00618  391 LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAqcekLEKIHLQESAQSLKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1005 TEKGL--KEQLSEQTHKCRQRDEEVKKGKQENER--------------LRADLAALQKELQDRNALAEEAREAERALSGK 1068
Cdd:TIGR00618  471 REQQLqtKEQIHLQETRKKAVVLARLLELQEEPCplcgscihpnparqDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1069 ADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSK------ 1142
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEqdlqdv 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1143 ----QRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGimkASLREKEEESQKKTKEVSKLQTEVQTTKQA 1218
Cdd:TIGR00618  631 rlhlQQCSQELALKLTALHALQLTLTQERVR--EHALSIRVLPKELL---ASRQLALQKMQSEKEQLTYWKEMLAQCQTL 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1219 LKNLET------REVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSA---KDEKELLHLSIEQEIRDQKE 1288
Cdd:TIGR00618  706 LRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLKARTEAhfnNNEEVTAALQTGAELSHLAA 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1289 RCDKSLTTIMELQQRIQESAKQIEAK-----DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDL 1363
Cdd:TIGR00618  786 EIQFFNRLREEDTHLLKTLEAEIGQEipsdeDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLT 865


                   ...
gi 1039794306 1364 QQQ 1366
Cdd:TIGR00618  866 QEQ 868
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 308-1167 3.21e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 3.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  308 IENEDLREKLRKIqqEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKyfesdh 387
Cdd:TIGR02169  211 ERYQALLKEKREY--EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIK------ 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  388 pGPGSYPSNR-KEDMLHKQGQMYTTEPQCASpgipphmhsrSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQD 466
Cdd:TIGR02169  283 -DLGEEEQLRvKEKIGELEAEIASLERSIAE----------KERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  467 RLKFQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSH 543
Cdd:TIGR02169  352 RDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQEELQRLSEELAD-----LN 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  544 RIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQL 623
Cdd:TIGR02169  427 AAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE-------AEAQA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  624 KELGAKLALSVPTEKfesMKSSLSNDINEKVKRLAEVGRDY----ESAQG-EIRQLKRDLESVRAQHIrpeehEQLRSRl 698
Cdd:TIGR02169  500 RASEERVRGGRAVEE---VLKASIQGVHGTVAQLGSVGERYataiEVAAGnRLNNVVVEDDAVAKEAI-----ELLKRR- 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  699 eqksgelgkKVSELTL----KNQTLQKDVEKLHADNKL---LNqqvhslTVEMKTRYVP---------LRVS------EE 756
Cdd:TIGR02169  571 ---------KAGRATFlplnKMRDERRDLSILSEDGVIgfaVD------LVEFDPKYEPafkyvfgdtLVVEdieaarRL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  757 MKKSHDVNVE-DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQLSELN 835
Cdd:TIGR02169  636 MGKYRMVTLEgELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGL-------KRELSSLQSELRRIENRLDELS 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  836 KKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRN 914
Cdd:TIGR02169  709 QELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEAlNDLEARL 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  915 LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplAR 994
Cdd:TIGR02169  789 SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN------GK 862

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  995 LEECERKFKATEKGLkeqlseqthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1074
Cdd:TIGR02169  863 KEELEEELEELEAAL-----------RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1075 QLKDLsqkysdvkserEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE------ELRSKQRCLER 1148
Cdd:TIGR02169  932 ELSEI-----------EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEvlkrldELKEKRAKLEE 1000

                          890
                   ....*....|....*....
gi 1039794306 1149 EQQTVSQLQQLLENQKNSS 1167
Cdd:TIGR02169 1001 ERKAILERIEEYEKKKREV 1019
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 70-224 3.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.05  E-value: 3.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   70 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHdAAMADCP 149
Cdd:PHA02878   168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH-ISVGYCK 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306  150 SS--IQLLCDHGASVNAKD-IDGRTPLVLATQmcRPTICQLLIDRGADVNSRDKQNRTAL-MLGCEYGCRDAVEVLVKN 224
Cdd:PHA02878   247 DYdiLKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISN 323
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 446-1296 1.37e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 60.07  E-value: 1.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  446 NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalalecervkedsdeqikqLEDALKDVQKRMYESegKVKQMQT 525
Cdd:TIGR01612  944 KEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINE---------------------LDKAFKDASLNDYEA--KNNELIK 1000

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  526 HFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGEFKRDEGRLVEE-NKRLQKECG 603
Cdd:TIGR01612 1001 YFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSiYNIIDEIEKEIGKNIELlNKEILEEAE 1080

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  604 TCEVELE--RRGRRVVELEGQLKELGAKLALSVptEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESV 681
Cdd:TIGR01612 1081 INITNFNeiKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDV 1158

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  682 RAQHIRPEEHEQLRSRLEQKSGELGKK------VSELTLKNQTLQKD---VEKLHADNKLLNQQVHSLTVEMKTRyvPLR 752
Cdd:TIGR01612 1159 ADKAISNDDPEEIEKKIENIVTKIDKKkniydeIKKLLNEIAEIEKDktsLEEVKGINLSYGKNLGKLFLEKIDE--EKK 1236

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  753 VSEEMKKSHDVNVEDLNkKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELmglkSNIAELKKQLS 832
Cdd:TIGR01612 1237 KSEHMIKAMEAYIEDLD-EIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENI----SDIREKSLKII 1311

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  833 ELNKKcgegqekiralMSENSSLKKTLSSQYVPAKTH-EEVKASLNSTVEKTN-RALLEAKKRFDDTSQEVSKLRDENEV 910
Cdd:TIGR01612 1312 EDFSE-----------ESDINDIKKELQKNLLDAQKHnSDINLYLNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKN 1380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  911 LRRNLENVQNQMKA--DYVSLEE-HSRRMSTVSQSLKEAQEANAAILADHrqgqeeIVSLHAEIKAQKKELDTIQECIKL 987
Cdd:TIGR01612 1381 IKDELDKSEKLIKKikDDINLEEcKSKIESTLDDKDIDECIKKIKELKNH------ILSEESNIDTYFKNADENNENVLL 1454

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  988 KYaplarlEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLradlaalqKELQDRNALAEEareaeralsg 1067
Cdd:TIGR01612 1455 LF------KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGC--------KDEADKNAKAIE---------- 1510

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLK----DLSQKYSDVKSEREKlveEKAKQASEILAAQNLLQKQPVPLEQvealkkslnGTIEQLKEELRSKQ 1143
Cdd:TIGR01612 1511 KNKELFEQYKkdvtELLNKYSALAIKNKF---AKTKKDSEIIIKEIKDAHKKFILEA---------EKSEQKIKEIKKEK 1578

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1144 RCLERE-------QQTVSQLQQLLENQKNSSVTLA-------EHLKLKEALEKEVGIMkaSLREKEEESQKKTKEVSKLQ 1209
Cdd:TIGR01612 1579 FRIEDDaakndksNKAAIDIQLSLENFENKFLKISdikkkinDCLKETESIEKKISSF--SIDSQDTELKENGDNLNSLQ 1656

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1210 TEVQTTKQALKNLETRevvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEEKVS--AKDEKELLHlSIEQEIRDQK 1287
Cdd:TIGR01612 1657 EFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKeiAIANKEEIE-SIKELIEPTI 1727


                   ....*....
gi 1039794306 1288 ERCDKSLTT 1296
Cdd:TIGR01612 1728 ENLISSFNT 1736
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 653-1336 2.14e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.08  E-value: 2.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  653 KVKRLAEVGRDYESAQGEIRQLKR-----DLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 727
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFgyksdETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDR 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  728 ADNKLLNQQvhsLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNK--KLSEATQRYTEKKQEAERLLAE---NDKLTKNVSR 802
Cdd:pfam12128  322 SELEALEDQ---HGAFLDADIETAAADQEQLPSWQSELENLEErlKALTGKHQDVTAKYNRRRSKIKeqnNRDIAGIKDK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  803 LEAVFVAPEK-HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSEnssLKKTLSSqyvpAKTHEEVKASLNSTVE 881
Cdd:pfam12128  399 LAKIREARDRqLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGE---LKLRLNQ----ATATPELLLQLENFDE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  882 KTNRALLEAKKRFddtsQEVSKLRDENEVLRRNLENVQnqmkadyVSLEEHSRRMSTVSQSLKEAQEanaailadhrQGQ 961
Cdd:pfam12128  472 RIERAREEQEAAN----AEVERLQSELRQARKRRDQAS-------EALRQASRRLEERQSALDELEL----------QLF 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  962 EEIVSLHAEIKaqkKELDTIQECIKlKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1041
Cdd:pfam12128  531 PQAGTLLHFLR---KEAPDWEQSIG-KVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERL 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1042 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP-LEQ 1120
Cdd:pfam12128  607 DKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANErLNS 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1121 VEALKKSLNGTIEQLKEELRSKQRCLEREQQtvsqlQQLLENQKNSSVTLAehlKLKEALEKEVGIMKASLREKEEESQK 1200
Cdd:pfam12128  687 LEAQLKQLDKKHQAWLEEQKEQKREARTEKQ-----AYWQVVEGALDAQLA---LLKAAIAARRSGAKAELKALETWYKR 758

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1201 KTKE-------VSKLQTEVQTTKQALKNLETRE--------------VVDMSKYKATKNDLETQISNLNDKLASLnrkyd 1259
Cdd:pfam12128  759 DLASlgvdpdvIAKLKREIRTLERKIERIAVRRqevlryfdwyqetwLQRRPRLATQLSNIERAISELQQQLARL----- 833

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1260 QACEEKVSAKDEKELlhlsieQEIRDQKERCDKSLTTIMELQQRIQE--SAKQIEAKDNKITELLNDVERLKQALNGLS 1336
Cdd:pfam12128  834 IADTKLRRAKLEMER------KASEKQQVRLSENLRGLRCEMSKLATlkEDANSEQAQGSIGERLAQLEDLKLKRDYLS 906
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 83-267 3.05e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 3.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   83 LECLNAILTHGIDVATR--DSA---------GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSS 151
Cdd:PHA02875     4 VALCDAILFGELDIARRllDIGinpnfeiydGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  152 IQLLCDHGASVNakDI---DGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADL 228
Cdd:PHA02875    84 VEELLDLGKFAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039794306  229 TLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGGGR 267
Cdd:PHA02875   162 DIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKN 200
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 498-1095 3.07e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.41  E-value: 3.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  498 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQS 577
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  578 EMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRL 657
Cdd:COG1196    308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL------AEAEEALLEAEAELAEAEEEL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  658 AEVGRDYESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQV 737
Cdd:COG1196    382 EELAEELLEALRAAAELAAQLEELEEAE---EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  738 HSLTVEMKTRYVPLRVSEEmkkshdvNVEDLNKKLSEATQRYTEKKQEAE------------RLLAENDKLTKNVSRLEA 805
Cdd:COG1196    459 EALLELLAELLEEAALLEA-------ALAELLEELAEAAARLLLLLEAEAdyegflegvkaaLLLAGLRGLAGAVAVLIG 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  806 VFVAPEKHEKELMGlkSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNR 885
Cdd:COG1196    532 VEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLR 609

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  886 ALLEAKKRFDDTSQevsklrdENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 965
Cdd:COG1196    610 EADARYYVLGDTLL-------GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  966 SLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1045
Cdd:COG1196    683 ELAERLAEEELELEEALL----------AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA 752

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039794306 1046 KELQDRNALAEEAREAERALSGK--------------ADELSKQLKDLSQKYSDVKSEREKLVE 1095
Cdd:COG1196    753 LEELPEPPDLEELERELERLEREiealgpvnllaieeYEELEERYDFLSEQREDLEEARETLEE 816
Ank_4 pfam13637
Ankyrin repeats (many copies);
70-123 3.46e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.46e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306   70 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLL 123
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
136-189 3.70e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.70e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306  136 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLI 189
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 152-249 3.91e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 3.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  152 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLL 231
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|....*...
gi 1039794306  232 DALGHDSSYYARIGDNLD 249
Cdd:PTZ00322   178 GANAKPDSFTGKPPSLED 195
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 447-726 4.71e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 4.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  447 EILKKELETLRTYYDSAKQDRLKFQNE---LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQM 523
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  524 QTHFLALKEHLTNEAATGS--HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKE 601
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAatERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  602 CGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDINEKVKRLAEVGRD--------YESAQGEIRQ 673
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLA------QLELRLEGLEVRIDNLQERLSEEYSLtleeaealENKIEDDEEE 969

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  674 LKRDLESVRAQHIR--------PEEHEQLRSRLEqksgELGKKVSELTLKNQTLQKDVEKL 726
Cdd:TIGR02168  970 ARRRLKRLENKIKElgpvnlaaIEEYEELKERYD----FLTAQKEDLTEAKETLEEAIEEI 1026
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 22-236 8.42e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 8.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   22 PTAVASTQSAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGID 95
Cdd:TIGR00870    3 PLDIVPAEESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   96 VATrdsaGRNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASV 162
Cdd:TIGR00870   79 GAV----GDTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  163 NAK----------DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY--------- 212
Cdd:TIGR00870  155 PARacgdffvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmyn 234

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039794306  213 -------GCRDAVEV-LVKNGADLTLLDALGH 236
Cdd:TIGR00870  235 falslldKLRDSKELeVILNHQGLTPLKLAAK 266
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 964-1376 1.17e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.57  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  964 IVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAA 1043
Cdd:TIGR04523   28 ANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1044 LQKELQDRNalaeeareaeralsgkadelsKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEA 1123
Cdd:TIGR04523  108 INSEIKNDK---------------------EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1124 LKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTK 1203
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTT 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1204 EVSKLQTEVQTTKQALKNLETR---EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV-----SAKDEKELL 1275
Cdd:TIGR04523  247 EISNTQTQLNQLKDEQNKIKKQlseKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELkselkNQEKKLEEI 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1276 HLSI---EQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQL 1352
Cdd:TIGR04523  327 QNQIsqnNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKL 406

                          410       420
                   ....*....|....*....|....
gi 1039794306 1353 VDTLQQRVRDLQQQLADADRQHQE 1376
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIER 430
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
497-712 1.42e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  497 EQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTNEAATgshRIIEELREQLKDLKGKYEGASAEVGKLRSQI 574
Cdd:COG4913    249 EQIELLEPIRELAERyaAARERLAELEYLRAALRLWFAQRRLELLE---AELEELRAELARLEAELERLEARLDALREEL 325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  575 kqsEMLVGEFKRDEGRLVEenkRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSVPT-----EKFESMKSSLSND 649
Cdd:COG4913    326 ---DELEAQIRGNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalrAEAAALLEALEEE 399

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039794306  650 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRLEQksgELGKKVSEL 712
Cdd:COG4913    400 LEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNiPARLLALRDALAE---ALGLDEAEL 460
PRK01156 PRK01156
chromosome segregation protein; Provisional
 642-1231 3.38e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 54.91  E-value: 3.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  642 MKSSLSNDINEKVKRLAEVgRDYESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLEQKSGEL---GKKVSELTLKNQT 718
Cdd:PRK01156   140 MDSLISGDPAQRKKILDEI-LEINSLERNYDKLKDVIDMLRAE---ISNIDYLEEKLKSSNLELeniKKQIADDEKSHSI 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  719 LQKDVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLA-ENDKLT 797
Cdd:PRK01156   216 TLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiINDPVY 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  798 KNVSRLEAVFvapeKHEKELMGLKSNIAELKKQLS--ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKAS 875
Cdd:PRK01156   292 KNRNYINDYF----KYKNDIENKKQILSNIDAEINkyHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  876 LNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyVSLEEHSRRMSTVSQSL------KEAQEA 949
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEIN---VKLQDISSKVSSLNQRIralrenLDELSR 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  950 NAAILADH-----------RQGQEEIVS--------LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLK 1010
Cdd:PRK01156   445 NMEMLNGQsvcpvcgttlgEEKSNHIINhynekksrLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKI 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1011 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDR------NALAEEAREAERALSGKADELSKQLKDLSQKYS 1084
Cdd:PRK01156   525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSkrtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQ 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1085 DVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1164
Cdd:PRK01156   605 EIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLK 684

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306 1165 NSSVTLAEHLKLKEALEKEVGImkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNL-ETREVVDMS 1231
Cdd:PRK01156   685 KSRKALDDAKANRARLESTIEI----LRTRINELSDRINDINETLESMKKIKKAIGDLkRLREAFDKS 748
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 78-206 4.82e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   78 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 149
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  150 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
941-1403 9.95e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 9.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  941 QSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLkYAPLARLEECERKFKATEKGLkEQLSEQTHKC 1020
Cdd:COG4717     81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERL-EELEERLEEL 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1021 RQRDEEVKKGKQENERLRADLAALQKELQDRNALA-EEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK 1099
Cdd:COG4717    159 RELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1100 Q---------------ASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1164
Cdd:COG4717    239 AaleerlkearlllliAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEE 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1165 NSSVTLAEHLKLKEALEKEvgiMKASLREKEEESQKKTKEVSKLQTEVQttkqaLKNLETREVVDMSKYKAtkndletqi 1244
Cdd:COG4717    319 EELEELLAALGLPPDLSPE---ELLELLDRIEELQELLREAEELEEELQ-----LEELEQEIAALLAEAGV--------- 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1245 snlnDKLASLNRKYDQAcEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTimELQQRIQESAKQIEAKDNKITELLND 1324
Cdd:COG4717    382 ----EDEEELRAALEQA-EEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREE 454

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1325 VERLKQALNGLsqltyssgsptkRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYrtHLLSAAQGHMDEDVQAALLQ 1403
Cdd:COG4717    455 LAELEAELEQL------------EEDGELAELLQELEELKAELRELAEEWAALKLAL--ELLEEAREEYREERLPPVLE 519
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 646-1273 1.06e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 53.19  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  646 LSNDINEKVKRLAEVGRDYESAQGEIR-QLKRDLESVraQHIRPEEHEQLRSRLEQ------KSGELGKKVSELTLKNQT 718
Cdd:pfam05483  188 LNNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKI--QHLEEEYKKEINDKEKQvsllliQITEKENKMKDLTFLLEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  719 LQKDVEKLHADNKL-------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQrytEKKQEAERLLA 791
Cdd:pfam05483  266 SRDKANQLEEKTKLqdenlkeLIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTE---EKEAQMEELNK 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  792 ENDKLTKNVSRLEAVFVAPEKHEK-ELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpaKTHE 870
Cdd:pfam05483  343 AKAAHSFVVTEFEATTCSLEELLRtEQQRLEKNEDQLKIITMELQKKSSELEEMTKF-------------------KNNK 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  871 EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL----RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEA 946
Cdd:pfam05483  404 EVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  947 QEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEE 1026
Cdd:pfam05483  484 KLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1027 VK--KGKQENERLRADLAALQKELQDRnalaeeareaerALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1104
Cdd:pfam05483  564 VKckLDKSEENARSIEYEVLKKEKQMK------------ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1105 LAAQNllqkqpvpleQVEALKKSLNGTIEQLKEELRSKQRclEREQQTVSQlQQLLENQKNSSVTLAEHLKLKEALEKEV 1184
Cdd:pfam05483  632 NAYEI----------KVNKLELELASAKQKFEEIIDNYQK--EIEDKKISE-EKLLEEVEKAKAIADEAVKLQKEIDKRC 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1185 gimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE 1264
Cdd:pfam05483  699 ---QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQ-------SSAKAALEIELSNIKAELLSLKKQLEIEKEE 768


                   ....*....
gi 1039794306 1265 KVSAKDEKE 1273
Cdd:pfam05483  769 KEKLKMEAK 777
PRK01156 PRK01156
chromosome segregation protein; Provisional
 880-1371 1.09e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 53.37  E-value: 1.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  880 VEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyvSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 959
Cdd:PRK01156   161 INSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKK----QIADDEKSHSITLKEIERLSIEYNNAMDDYNN 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  960 GQEEIvslhAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1039
Cdd:PRK01156   237 LKSAL----NELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQ 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1040 DLAALQKELQDRNALAEEAREAERALS------GKADELSKQLKDLSQKYSD-------VKSEREKLVEEKAKQASEILA 1106
Cdd:PRK01156   313 ILSNIDAEINKYHAIIKKLSVLQKDYNdyikkkSRYDDLNNQILELEGYEMDynsylksIESLKKKIEEYSKNIERMSAF 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1107 AQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS---KQRCLEREQQTVSQLQQLLENQKNSSVTlAEHLKlKEALEKE 1183
Cdd:PRK01156   393 ISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSlnqRIRALRENLDELSRNMEMLNGQSVCPVC-GTTLG-EEKSNHI 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1184 VGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACE 1263
Cdd:PRK01156   471 INHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1264 ekvsAKDEKELLHLSIEQEIRDQ--KERCDKSLTTIMELQQRIQESAKQI---EAKDNKITELLNDVERLKQALNGLSQL 1338
Cdd:PRK01156   551 ----IKNRYKSLKLEDLDSKRTSwlNALAVISLIDIETNRSRSNEIKKQLndlESRLQEIEIGFPDDKSYIDKSIREIEN 626

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1039794306 1339 TYSSGSPTKRQSQ----LVDTLQQRVRDLQQQLADAD 1371
Cdd:PRK01156   627 EANNLNNKYNEIQenkiLIEKLRGKIDNYKKQIAEID 663
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 886-1107 1.39e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  886 ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 965
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  966 SLHAEIKAQKKEL-DTIQECIKLKYAPLARL----EECERKFKATE--KGLKEQLSEQTHKCRQRDEEVKKGKQENERLR 1038
Cdd:COG4942     94 ELRAELEAQKEELaELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAER 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039794306 1039 ADLAALQKELQDR----NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1107
Cdd:COG4942    174 AELEALLAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
46 PHA02562
endonuclease subunit; Provisional
 496-727 1.40e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 52.71  E-value: 1.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  496 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK 575
Cdd:PHA02562   187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  576 QSEMLVGEFKRDEgRLVEENkrlqKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMKsSLSNDINEKVK 655
Cdd:PHA02562   266 KIKSKIEQFQKVI-KMYEKG----GVCPTCTQQISEGPDRITKIKDKLKELQHSLEKL--DTAIDELE-EIMDEFNEQSK 337

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039794306  656 RLAEVgrdyesaQGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 727
Cdd:PHA02562   338 KLLEL-------KNKISTNKQSLITLVDKAKKVKaAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY 403
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 782-1377 1.53e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.92  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  782 KKQEAERLLAEND------KLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-LMSENSS 854
Cdd:pfam12128  219 NRQQVEHWIRDIQaiagimKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQlLRTLDDQ 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  855 LKKTLSSQYVPAKTHEEVKASLNSTVEktnrALLEAKKRFDDTSQEVSKLRDENEVLRRN-LENVQNQMKAdyvsLEEHS 933
Cdd:pfam12128  299 WKEKRDELNGELSAADAAVAKDRSELE----ALEDQHGAFLDADIETAAADQEQLPSWQSeLENLEERLKA----LTGKH 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  934 RRMSTVSQSLKEA-QEANAAILADHRQGQ----EEIVSLHAEIKAQKKELDtiQECIKLKYAPLARLEECERKFKATEKG 1008
Cdd:pfam12128  371 QDVTAKYNRRRSKiKEQNNRDIAGIKDKLakirEARDRQLAVAEDDLQALE--SELREQLEAGKLEFNEEEYRLKSRLGE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1009 LKEQL------SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELqdrnalaeeareaeRALSGKADELSKQLKDLSQK 1082
Cdd:pfam12128  449 LKLRLnqatatPELLLQLENFDERIERAREEQEAANAEVERLQSEL--------------RQARKRRDQASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1083 YSDVKSEREKLVEEKAKQASEILAaqnLLQKQPVPLEQVEA--LKKSLNGTIEqLKEELRSKQRCLEREQQTVS-QLQQL 1159
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLH---FLRKEAPDWEQSIGkvISPELLHRTD-LDPEVWDGSVGGELNLYGVKlDLKRI 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1160 lenQKNSSVTLAEHLKLK-EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdmskykatkn 1238
Cdd:pfam12128  591 ---DVPEWAASEEELRERlDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR----------- 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1239 DLETQISNLNDKLA-SLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKErcdKSLTTIMELQQRIQESakqIEAKDNK 1317
Cdd:pfam12128  657 RLFDEKQSEKDKKNkALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKE---QKREARTEKQAYWQVV---EGALDAQ 730

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039794306 1318 I----TELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEV 1377
Cdd:pfam12128  731 LallkAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEV 794
PHA02798 PHA02798
ankyrin-like protein; Provisional
 152-255 1.64e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.53  E-value: 1.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  152 IQLLCDHGASVNAKDIDGRTPL--VLATQMCRPT---ICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLVK 223
Cdd:PHA02798    54 VKLFINLGANVNGLDNEYSTPLctILSNIKDYKHmldIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1039794306  224 NGADLTLLDALGHDS-SYYARIGDNLDIlNLLK 255
Cdd:PHA02798   134 NGADTTLLDKDGFTMlQVYLQSNHHIDI-EIIK 165
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
496-687 1.70e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.00  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  496 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLA---LKEHLTNEAATGS-HRIIEELREQLKDLK---GKYEGASAEVG 568
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREAlqrLAEYSWDEIDVASaEREIAELEAELERLDassDDLAALEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  569 KLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVelEGQLKELGAKLALSVPTEKFESMKSSLSN 648
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAAALGDAVERELRENLEE 773

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039794306  649 DInekvkrlaevgrdyESAQGEIRQLKRDLESVRAQHIR 687
Cdd:COG4913    774 RI--------------DALRARLNRAEEELERAMRAFNR 798
Ank_2 pfam12796
Ankyrin repeats (3 copies);
173-254 1.80e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  173 LVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGAdltlLDALGHDSS--YYARIGDNLDI 250
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 1039794306  251 LNLL 254
Cdd:pfam12796   77 VKLL 80
PRK01156 PRK01156
chromosome segregation protein; Provisional
 794-1372 1.87e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 1.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  794 DKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSqyvpAKTHEEVK 873
Cdd:PRK01156   176 DMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMK 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  874 ASLNSTVEKTNRAL---LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN 950
Cdd:PRK01156   252 NRYESEIKTAESDLsmeLEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  951 AAILADHRQgQEEIVSLHAEIKAQKKELDTIQEciklKYAPLArleeceRKFKATEKGLKEQLSEQTHKCRQRDEEVKKG 1030
Cdd:PRK01156   332 SVLQKDYND-YIKKKSRYDDLNNQILELEGYEM----DYNSYL------KSIESLKKKIEEYSKNIERMSAFISEILKIQ 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1031 KQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQK---------YSDVKSER--EKLVEEKAK 1099
Cdd:PRK01156   401 EIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttLGEEKSNHiiNHYNEKKSR 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1100 QASEILAAQNLLQKQPVPLEQVEALKKSLNGtieqlkeelrSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE-HLKLKE 1178
Cdd:PRK01156   481 LEEKIREIEIEVKDIDEKIVDLKKRKEYLES----------EEINKSINEYNKIESARADLEDIKIKINELKDkHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1179 ALEKEVGIMKASLREKEEE-----SQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1253
Cdd:PRK01156   551 IKNRYKSLKLEDLDSKRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANN 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1254 LNRKYDQAcEEKVSAKDEkellhlsIEQEIRDQKERCDKslttimelQQRIQESAKQIEAKDNKITELLNDVERLKQALN 1333
Cdd:PRK01156   631 LNNKYNEI-QENKILIEK-------LRGKIDNYKKQIAE--------IDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1039794306 1334 glsqltyssgSPTKRQSQLVDTLQQRVRDLQQQLADADR 1372
Cdd:PRK01156   695 ----------ANRARLESTIEILRTRINELSDRINDINE 723
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 670-1330 1.93e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  670 EIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQtLQKDVEKLHADNKLLNQQVHSLtveMKTRYV 749
Cdd:pfam02463  184 NLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY-LKLNEERIDLLQELLRDEQEEI---ESSKQE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  750 PLRVSEEMKKSHDVNVEDLN-KKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFV--APEKHEKELMGLKSNIAE 826
Cdd:pfam02463  260 IEKEEEKLAQVLKENKEEEKeKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESekEKKKAEKELKKEKEEIEE 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  827 LKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRD 906
Cdd:pfam02463  340 LEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLED 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  907 ENEVLRRNLENVQNqmkadyvsleehsrrmstVSQSLKEAQEANAAILADHRQGQEEI-VSLHAEIKAQKKELDTIQECI 985
Cdd:pfam02463  420 LLKEEKKEELEILE------------------EEEESIELKQGKLTEEKEELEKQELKlLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  986 KLKYapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERAL 1065
Cdd:pfam02463  482 LQEQ--LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADE 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1066 SGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQA-----SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR 1140
Cdd:pfam02463  560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAvleidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1141 SKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQT--TKQA 1218
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKklKLEA 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1219 LKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIM 1298
Cdd:pfam02463  720 EELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          650       660       670
                   ....*....|....*....|....*....|..
gi 1039794306 1299 ELQQRIQESAKQIEAKDNKITELLNDVERLKQ 1330
Cdd:pfam02463  800 EEELRALEEELKEEAELLEEEQLLIEQEEKIK 831
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 811-1385 2.32e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.42  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  811 EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSS-------LKKTLSSQYVPAKTHE-------EVKASL 876
Cdd:pfam05483  109 QENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNAtrhlcnlLKETCARSAEKTKKYEyereetrQVYMDL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  877 NSTVEKTNRALLEAKKRFDDTSQEVS-KLRDENEVL-------RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQE 948
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKIqhleeeyKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  949 ANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplarleecerKFKATEKGLKEQLSEQTHKCRQRDEEVK 1028
Cdd:pfam05483  269 KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQ--------------RSMSTQKALEEDLQIATKTICQLTEEKE 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1029 KGKQENERLRADLAALQKELQdrnalaeeareaerALSGKADELskqlkdlsqkysdVKSEREKLveEKAKQASEILAAQ 1108
Cdd:pfam05483  335 AQMEELNKAKAAHSFVVTEFE--------------ATTCSLEEL-------------LRTEQQRL--EKNEDQLKIITME 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1109 nlLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaEHLKLKEALEKEVGIMK 1188
Cdd:pfam05483  386 --LQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQ-------ELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1189 ASLREKEEESQKKTKEVSKLQTEVQttKQALKNLETREVVDMSKYKATKNDLETQ------------ISNLNDKLASLNR 1256
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELTAHCDKLLLENKELTQEASdmtlelkkhqedIINCKKQEERMLK 534

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1257 KYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1336
Cdd:pfam05483  535 QIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELH 614

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1039794306 1337 QLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHL 1385
Cdd:pfam05483  615 QENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEI 663
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 451-1338 2.54e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 2.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  451 KELETLRTYYDSAKQDRLKFQNELAHKVAEckalaLECERvkedsdEQIKQLEDALKDVQKRMYESEgkvkQMQTHFLAL 530
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQ-----LESSR------EIVKSYENELDPLKNRLKEIE----HNLSKIMKL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  531 KEHLTNEAATGSHRiiEELREQLKDLKGK-YEGASAEVGKLRsqikqsemlvgEFKRDEGRLVEEnkrlqkECGTCEVEL 609
Cdd:TIGR00606  268 DNEIKALKSRKKQM--EKDNSELELKMEKvFQGTDEQLNDLY-----------HNHQRTVREKER------ELVDCQREL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  610 ERRGRRVVELEGQLKELgaklalsvpteKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpE 689
Cdd:TIGR00606  329 EKLNKERRLLNQEKTEL-----------LVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK---N 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  690 EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhslTVEMKTRYVPLRVSE-EMKKSHDVNVEDL 768
Cdd:TIGR00606  395 FHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGR-----TIELKKEILEKKQEElKFVIKELQQLEGS 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  769 NKKLSEATQRYTekKQEAERLLAENDKLT-------KNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEG 841
Cdd:TIGR00606  470 SDRILELDQELR--KAERELSKAEKNSLTetlkkevKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDK 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  842 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 921
Cdd:TIGR00606  548 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDK 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  922 MkADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLhaeikaqkkeLDTIQECIKLkyaplarleeCERK 1001
Cdd:TIGR00606  628 L-FDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQL----------TDENQSCCPV----------CQRV 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1002 FKaTEKGLKEQLSEQTHKCR-------QRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1074
Cdd:TIGR00606  687 FQ-TEAELQEFISDLQSKLRlapdklkSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKN 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1075 QLKDLSQKYSDVKSErEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNG--TIEQLKEELRSKQRCLEREQQT 1152
Cdd:TIGR00606  766 DIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLdrTVQQVNQEKQEKQHELDTVVSK 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1153 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK-------QALKNLETR 1225
Cdd:TIGR00606  845 IELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKeqdspleTFLEKDQQE 924

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1226 EVVDMSKYKATK-------NDLETQISNLNDKLASLNRKYDQACEEKVSAKdEKELLHLSIE-QEIRDQKERCDKSLTTI 1297
Cdd:TIGR00606  925 KEELISSKETSNkkaqdkvNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK-ETELNTVNAQlEECEKHQEKINEDMRLM 1003

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....
gi 1039794306 1298 MEL--QQRIQESAKQIEAKDNKITELLNDVER-LKQALNGLSQL 1338
Cdd:TIGR00606 1004 RQDidTQKIQERWLQDNLTLRKRENELKEVEEeLKQHLKEMGQM 1047
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1025-1226 2.72e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 2.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1025 EEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1104
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1105 LAAQNLLQKQPV---PLEQVEALKKSLNGT-----------IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-SVT 1169
Cdd:COG4942    100 EAQKEELAELLRalyRLGRQPPLALLLSPEdfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAElEAL 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1170 LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1226
Cdd:COG4942    180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 152-254 3.75e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 3.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  152 IQLLCDHGASVNAKDID-GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTL 230
Cdd:PHA02878   150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                           90       100
                   ....*....|....*....|....*...
gi 1039794306  231 LDALG----HDSSYYARigdNLDILNLL 254
Cdd:PHA02878   230 RDKCGntplHISVGYCK---DYDILKLL 254
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 494-936 3.82e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 3.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  494 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHltNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSq 573
Cdd:pfam01576  107 DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQ--NSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKN- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  574 ikQSEMLVGEFkrdEGRLVEENK---RLQKECGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDI 650
Cdd:pfam01576  184 --KHEAMISDL---EERLKKEEKgrqELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLA------KKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  651 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH-------------------------EQLRSRLEQKSGEL 705
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdlgeelealkteledtldttaaqQELRSKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  706 GKKVSELTLKNQTLQKDVEKLHAD----------------------NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDV 763
Cdd:pfam01576  333 KKALEEETRSHEAQLQEMRQKHTQaleelteqleqakrnkanlekaKQALESENAELQAELRTLQQAKQDSEHKRKKLEG 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  764 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 843
Cdd:pfam01576  413 QLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLESQLQDTQELLQEETRQKLNLST 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  844 KIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 923
Cdd:pfam01576  490 RLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562

                          490
                   ....*....|....*.
gi 1039794306  924 ---ADYVSLEEHSRRM 936
Cdd:pfam01576  563 ekaAAYDKLEKTKNRL 578
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
473-959 3.87e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 3.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  473 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmyesegkvkqmqthflalKEHLTNEAATGSHRiIEELREQ 552
Cdd:PRK02224   255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE------------------RDDLLAEAGLDDAD-AEAVEAR 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  553 LKDLKGKYEGASAEVGKLRSQI----KQSEMLVGEFKRDEGR---LVEENKRLQKECGTCEVELERRGRRVVELEGQLKE 625
Cdd:PRK02224   316 REELEDRDEELRDRLEECRVAAqahnEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRREEIEELEEEIEE 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  626 LGAKLA-LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVR----AQHIRPEEHEQLRSRLEQ 700
Cdd:PRK02224   396 LRERFGdAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRE 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  701 KSGELGKKVSELTLKNQTLQKDVEKLHADNKL------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 774
Cdd:PRK02224   476 RVEELEAELEDLEEEVEEVEERLERAEDLVEAedrierLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEE 555

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  775 ATQRYTEKKQEAERLLAE----NDKLTKNVSRLEAVfvapekheKELMGLKSNIAELKKQLSELNKK---CGEGQEKIRA 847
Cdd:PRK02224   556 KREAAAEAEEEAEEAREEvaelNSKLAELKERIESL--------ERIRTLLAAIADAEDEIERLREKreaLAELNDERRE 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  848 LMSENSSLKKTLSSQYVPAKTHE--EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEvlrrNLENVQNQMKAd 925
Cdd:PRK02224   628 RLAEKRERKRELEAEFDEARIEEarEDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELE----ELEELRERREA- 702

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1039794306  926 yvsLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 959
Cdd:PRK02224   703 ---LENRVEALEALYDEAEELESMYGDLRAELRQ 733
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 427-923 4.07e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.56  E-value: 4.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  427 RSMLRPLELSLPSQTSYSE-NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA 505
Cdd:TIGR04523  193 KNKLLKLELLLSNLKKKIQkNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  506 LKDVQKrmyeSEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEgasaevgKLRSQIKQSEMLVGEFK 585
Cdd:TIGR04523  273 QKELEQ----NNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLE-------EIQNQISQNNKIISQLN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  586 RDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYE 665
Cdd:TIGR04523  342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI------KNLESQINDLESKIQNQEKLNQQKDEQIK 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  666 SAQGEIRQLKRDLESVRAQHIrpeEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMK 745
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETII---KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELK 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  746 TRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRY----TEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLK 821
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIekleSEKKEKESKISDLEDELNKDDFELKK-----ENLEKEIDEKN 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  822 SNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaktheevkASLNSTVEKTNRALLEAKKRFDDTSQEV 901
Cdd:TIGR04523  568 KEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEI--------------EEKEKKISSLEKELEKAKKENEKLSSII 633

                          490       500
                   ....*....|....*....|..
gi 1039794306  902 SKLRDENEVLRRNLENVQNQMK 923
Cdd:TIGR04523  634 KNIKSKKNKLKQEVKQIKETIK 655
PRK01156 PRK01156
chromosome segregation protein; Provisional
 302-898 5.09e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.06  E-value: 5.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  302 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADD---LESEREKLKSLLAAKEKQHEEslrtIEALKN 378
Cdd:PRK01156   205 QIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMknrYESEIKTAESDLSMELEKNNY----YKELEE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  379 RFKYFESDhpgPGSYPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELslpsQTSYSENEILKKELETLRT 458
Cdd:PRK01156   281 RHMKIIND---PVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVL----QKDYNDYIKKKSRYDDLNN 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  459 YYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA----------LKDVQKRMYESEGKVKQMQTHFL 528
Cdd:PRK01156   354 QILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQeidpdaikkeLNEINVKLQDISSKVSSLNQRIR 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  529 ALKEHLtneaatgshriiEELREQLKDLKGKyegASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVE 608
Cdd:PRK01156   434 ALRENL------------DELSRNMEMLNGQ---SVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEK 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  609 LERRGRRVVELEGQLKElgaklALSVPTEKFESMKSSLSnDINEKVKRLAEVGRDYESAQGEIRQLK-RDLESVRAQH-- 685
Cdd:PRK01156   499 IVDLKKRKEYLESEEIN-----KSINEYNKIESARADLE-DIKIKINELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWln 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  686 ----IRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSh 761
Cdd:PRK01156   573 alavISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGK- 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  762 dvnVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCgEG 841
Cdd:PRK01156   652 ---IDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETL-ES 727

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306  842 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNStveKTNRALLEAKKRFDDTS 898
Cdd:PRK01156   728 MKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTS---LTRKYLFEFNLDFDDID 781
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 842-1368 7.22e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.74  E-value: 7.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  842 QEKIRALMSENSSLKKTLSSQYVPAKTHE----EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLEN 917
Cdd:TIGR00618  151 QGEFAQFLKAKSKEKKELLMNLFPLDQYTqlalMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKH 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  918 VQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAiladhRQGQEEIVSLHAEIKAQKKELDtiQECIKLKYAP-LARLE 996
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQL-----RARIEELRAQEAVLEETQERIN--RARKAAPLAAhIKAVT 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  997 ECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE----- 1071
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTqhiht 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1072 LSKQLKDLSQKYSDVKSEREKLVEEKAKQASEiLAAQNLLQKQPVPLEQVEALkkslngtieqlkeelrskqrclerEQQ 1151
Cdd:TIGR00618  384 LQQQKTTLTQKLQSLCKELDILQREQATIDTR-TSAFRDLQGQLAHAKKQQEL------------------------QQR 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1152 TVSQLQQLLENQknssvtlAEHLKLKEALEKEvgiMKASLREKEEESQKK---TKEVSKLQTEVQTTKQALKNLETREVV 1228
Cdd:TIGR00618  439 YAELCAAAITCT-------AQCEKLEKIHLQE---SAQSLKEREQQLQTKeqiHLQETRKKAVVLARLLELQEEPCPLCG 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1229 DMSKYKATKNDLETQISNLNDKLASLNR-KYDQACEEKVSAKDEKELLHLsieQEIRDQKERCDKSLTTIMELQQRIQES 1307
Cdd:TIGR00618  509 SCIHPNPARQDIDNPGPLTRRMQRGEQTyAQLETSEEDVYHQLTSERKQR---ASLKEQMQEIQQSFSILTQCDNRSKED 585

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306 1308 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1368
Cdd:TIGR00618  586 IPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
489-700 1.06e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  489 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEHL---TNEAATGSHRIIEELREQLKDLKGKYEGASA 565
Cdd:COG3206    167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNGlvdLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  566 EVGKLRSQIKQSEMLVGEFKRDEG--RLVEENKRLQKEcgtcEVELERRGR----RVVELEGQLKELGAKLA-------- 631
Cdd:COG3206    241 RLAALRAQLGSGPDALPELLQSPViqQLRAQLAELEAE----LAELSARYTpnhpDVIALRAQIAALRAQLQqeaqrila 316

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  632 -LSVPTEKFESMKSSLSNDINEKVKRLAEVGRdyesAQGEIRQLKRDLESVRAQhirpeeHEQLRSRLEQ 700
Cdd:COG3206    317 sLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVEVAREL------YESLLQRLEE 376
PRK12704 PRK12704
phosphodiesterase; Provisional
 1077-1233 1.84e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 1.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1077 KDLSQKYSDVKSEREKLVEEKAKQASE-----ILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQ 1151
Cdd:PRK12704    27 KIAEAKIKEAEEEAKRILEEAKKEAEAikkeaLLEAKEEIHKL---RNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1152 TVSQLQQLLENQKNSSvtlaehlklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEvQTTKQALKNLETREVVDMS 1231
Cdd:PRK12704   104 LLEKREEELEKKEKEL----------EQKQQELEKKEEELEELIEEQLQELERISGLTAE-EAKEILLEKVEEEARHEAA 172


                   ..
gi 1039794306 1232 KY 1233
Cdd:PRK12704   173 VL 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1147-1393 1.87e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1147 EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1226
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1227 vvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE-KVSAKDEKELLHLS--IEQEIRDQKERCDKSLTTIMELQQR 1303
Cdd:COG4942     93 -------AELRAELEAQKEELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLqyLKYLAPARREQAEELRADLAELAAL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1304 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRT 1383
Cdd:COG4942    166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245

                          250
                   ....*....|
gi 1039794306 1384 HLLSAAQGHM 1393
Cdd:COG4942    246 AGFAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1068-1295 2.09e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1147
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ--------------LAALERRIAALARRIRALEQELAALEAELA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 REQQTVSQLQQLLENQKN-------SSVTLAEHLKLKEALE----KEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1216
Cdd:COG4942     87 ELEKEIAELRAELEAQKEelaellrALYRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1217 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLT 1295
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 977-1367 2.23e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.53  E-value: 2.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  977 ELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK-------KGKQENERLRADLAALQKELQ 1049
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAgltrrlsAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1050 DRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN 1129
Cdd:pfam19220  101 EAEAAKEELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQ 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1130 GTIEQLKEELRSKQRCL-EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMK---ASLREKEEESQKKTKEV 1205
Cdd:pfam19220  181 ALSEEQAAELAELTRRLaELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRaerASLRMKLEALTARAAAT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1206 SKLQTEVQTtkqalknletrevvdmskykatkndletqisNLNDKLASLnRKYDQACEEKVSAKDEKELLHLSIEQEIRD 1285
Cdd:pfam19220  261 EQLLAEARN-------------------------------QLRDRDEAI-RAAERRLKEASIERDTLERRLAGLEADLER 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1286 QKERCDKSLTTIMELQQRIQESAKQIEAKDNKitellndverLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1365
Cdd:pfam19220  309 RTQQFQEMQRARAELEERAEMLTKALAAKDAA----------LERAEERIASLSDRIAELTKRFEVERAALEQANRRLKE 378


                   ..
gi 1039794306 1366 QL 1367
Cdd:pfam19220  379 EL 380
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-100 2.42e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 2.42e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306   40 LMKAAERGDVEKVSSILAKKGVhpgKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRD 100
Cdd:pfam12796   34 LHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
885-1383 2.59e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 2.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  885 RALLEAKKRFDDTSQEVSKLRDENEVLRRnLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQEANAAILADHRQ 959
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELEELRAELAR 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  960 GQEEIVSLHAEIKAQKKELDTIQEciKLKYAPLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1039
Cdd:COG4913    307 LEAELERLEARLDALREELDELEA--QIRGNGGDRLEQLEREIER----LERELEERERRRARLEALLAALGLPLPASAE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1040 DLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQ---PV 1116
Cdd:COG4913    381 EFAALRAEAAAL-----------------LEALEEELEALEEALAEAEAALRDLRRELRELEAEI---ASLERRKsniPA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1117 PLEQV-EALKKSLNGTIEQLK---E--ELRSKQ-----------------------------RCLEREQQT-------VS 1154
Cdd:COG4913    441 RLLALrDALAEALGLDEAELPfvgEliEVRPEEerwrgaiervlggfaltllvppehyaaalRWVNRLHLRgrlvyerVR 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1155 QLQQLLENQKNSSVTLAEHLKLKE-----ALEKEVG--------------------IMKASLREKEEESQKKTKEVSKLQ 1209
Cdd:COG4913    521 TGLPDPERPRLDPDSLAGKLDFKPhpfraWLEAELGrrfdyvcvdspeelrrhpraITRAGQVKGNGTRHEKDDRRRIRS 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1210 TEV--QTTKQALKNLETRevvdMSKYKATKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIR--- 1284
Cdd:COG4913    601 RYVlgFDNRAKLAALEAE----LAELEEELAEAEERLEALEAELDALQERREAL--QRLAEYSWDEIDVASAEREIAele 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1285 DQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQ 1364
Cdd:COG4913    675 AELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE-------LDELQDRLEAAEDLARLEL 747

                          570
                   ....*....|....*....
gi 1039794306 1365 QQLADADRQHQEVIAIYRT 1383
Cdd:COG4913    748 RALLEERFAAALGDAVERE 766
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 538-747 2.76e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  538 AATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVV 617
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  618 ELEGQLKELGAKLALSVPTEKFESMKSSL-----SNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPE--- 689
Cdd:COG4942     94 ELRAELEAQKEELAELLRALYRLGRQPPLalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEaer 173

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306  690 --------EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTR 747
Cdd:COG4942    174 aeleallaELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 107-235 3.00e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 3.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  107 LHLAAKYGHALCLQKLLQYNcpteHVDLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDI----------DGRT 171
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306  172 PLVLATQMCRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLVKNGADLTLLDALG 235
Cdd:cd22192     92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
46 PHA02562
endonuclease subunit; Provisional
 722-986 3.37e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 3.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  722 DVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQR----YTEKKQEAERLLAENDKLT 797
Cdd:PHA02562   161 DISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARkqnkYDELVEEAKTIKAEIEELT 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  798 knvSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgegqekirALMSENSSLKKTLSSQYvpaKTHEEVKASLN 877
Cdd:PHA02562   241 ---DELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKV---------IKMYEKGGVCPTCTQQI---SEGPDRITKIK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  878 STVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLrRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADH 957
Cdd:PHA02562   306 DKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKL-LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKL 384

                          250       260
                   ....*....|....*....|....*....
gi 1039794306  958 RQGQEEIVSLHAEIKAQKKELDTIQECIK 986
Cdd:PHA02562   385 QDELDKIVKTKSELVKEKYHRGIVTDLLK 413
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1068-1273 3.61e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 3.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRcle 1147
Cdd:COG3883     24 ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKL---QAEIAEAEAEIEERREELGERARALYR--- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 rEQQTVSQLQQLLENQKNSSVtlaehlklkealekevgIMKASLREKEEESQKKT-KEVSKLQTEVQTTKQALKNLETRE 1226
Cdd:COG3883     98 -SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADLlEELKADKAELEAKKAELEAKLAEL 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1039794306 1227 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKE 1273
Cdd:COG3883    160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 500-1382 4.11e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 48.25  E-value: 4.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  500 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEvgkLRSQIKQSEM 579
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  580 LVGEFKrdeGRLVEENKRLQKECGTCEVELERRG---RRVVELEGQLKELGAKLALS-VPTEKFESMKSSLSNDInEKVK 655
Cdd:pfam01576  230 QIAELR---AQLAKKEEELQAALARLEEETAQKNnalKKIRELEAQISELQEDLESErAARNKAEKQRRDLGEEL-EALK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  656 RLAEVGRDYESAQGEIR--------QLKRDLESVRAQHirPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 727
Cdd:pfam01576  306 TELEDTLDTTAAQQELRskreqevtELKKALEEETRSH--EAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  728 ADNKllnqqvhSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVF 807
Cdd:pfam01576  384 SENA-------ELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  808 VapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRAL 887
Cdd:pfam01576  457 I---KLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQL 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  888 LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK---ADYVSLEEHSRRMSTVSQSLKEAQEANAAILA--------- 955
Cdd:pfam01576  527 SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEekaAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSnlekkqkkf 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  956 DHRQGQEEIVSLH-------AEIKAQKKELDTIQECIKLKYAPLARlEECERKFKATEKGLKEQLSEQ--THKCRQRDEE 1026
Cdd:pfam01576  607 DQMLAEEKAISARyaeerdrAEAEAREKETRALSLARALEEALEAK-EELERTNKQLRAEMEDLVSSKddVGKNVHELER 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1027 VKKG-KQENERLRADLAALQKELQD---------------RNALAEEAREAERALSGKADELSKQLKDLsqkysdvkser 1090
Cdd:pfam01576  686 SKRAlEQQVEEMKTQLEELEDELQAtedaklrlevnmqalKAQFERDLQARDEQGEEKRRQLVKQVREL----------- 754

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1091 EKLVEEKAKQASEILAAQNLLQKQPVPLE-QVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQ-LQQLLENQKN 1165
Cdd:pfam01576  755 EAELEDERKQRAQAVAAKKKLELDLKELEaQIDAANKGREEAVKQLKKlqaQMKDLQRELEEARASRDEiLAQSKESEKK 834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1166 SSVTLAEHLKLKEALekevgimKASLREKEEESQkktkEVSKLQTEVQ---TTKQALKNLETREVVDMSKYKATKNDLET 1242
Cdd:pfam01576  835 LKNLEAELLQLQEDL-------AASERARRQAQQ----ERDELADEIAsgaSGKSALQDEKRRLEARIAQLEEELEEEQS 903

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1243 QISNLNDKLASLNRKYDQ-----ACEEKVSAKDEKELLHLsiEQEIRDQKERCD--------KSLTTIMELQQRIQESAK 1309
Cdd:pfam01576  904 NTELLNDRLRKSTLQVEQlttelAAERSTSQKSESARQQL--ERQNKELKAKLQemegtvksKFKSSIAALEAKIAQLEE 981

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039794306 1310 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYR 1382
Cdd:pfam01576  982 QLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARR 1054
COG5022 COG5022
Myosin heavy chain [General function prediction only];
962-1333 4.97e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 4.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  962 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKK----GKQENERL 1037
Cdd:COG5022    817 ACIIKLQKTIKREKKLRETEEVEFSLKAEVL--IQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqlqeLKIDVKSI 894

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1038 rADLAALQKELQDrnalaeeareaeralsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP 1117
Cdd:COG5022    895 -SSLKLVNLELES-----------------EIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPEL 956

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1118 LEqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkASLREKEEE 1197
Cdd:COG5022    957 NK--------LHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEST----KQLKELPVE 1024

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1198 SQKKTKEVSKLQTEvQTTKQALKNLETREVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLH 1276
Cdd:COG5022   1025 VAELQSASKIISSE-STELSILKPLQKLKGLLLLENNQLqARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEV 1103

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306 1277 LSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ----IEAKDNKITELLNDVERLKQALN 1333
Cdd:COG5022   1104 TNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQlvntLEPVFQKLSVLQLELDGLFWEAN 1164
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 789-1051 5.04e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 5.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  789 LLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpakt 868
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  869 heevkasLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevLRRNLENVQNQMKADYVSL---EEHSRRMSTVSQSLKE 945
Cdd:COG4942     74 -------LEQELAALEAELAELEKEIAELRAELEAQKEE---LAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKY 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  946 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIqeciklkyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDE 1025
Cdd:COG4942    144 LAPARREQAEELRADLAELAALRAELEAERAELEAL----------LAELEEERAALEALKAERQKLLARLEKELAELAA 213

                          250       260
                   ....*....|....*....|....*.
gi 1039794306 1026 EVKKGKQENERLRADLAALQKELQDR 1051
Cdd:COG4942    214 ELAELQQEAEELEALIARLEAEAAAA 239
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-155 7.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 7.21e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039794306  103 GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL 155
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 186-267 7.49e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 7.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  186 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGG 265
Cdd:PTZ00322    99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178


                   ..
gi 1039794306  266 GR 267
Cdd:PTZ00322   179 AN 180
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 643-1050 8.10e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 47.36  E-value: 8.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  643 KSSLSNDI-----NEKVKRLAEVGRDYESAQGE-IRQLKRDL--ESVRAQ-HIRP-----EEHEQLRSRLEQKSGELGKK 708
Cdd:pfam13166   29 KTTLSRLLrslelGEPHPKFANGKFEWTNGQPLdIRVFNRDFveENLSEQgEIKPiftlgEESIEIQEKIAKLKKEIKDH 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  709 VSELTLKNQTLQ---KDVEKLHAD-NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVnvEDLNKKLSEATQRYTEKKQ 784
Cdd:pfam13166  109 EEKLDAAEANLQkldKEKEKLEADfLDECWKKIKRKKNSALSEALNGFKYEANFKSRLL--REIEKDNFNAGVLLSDEDR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  785 EA------ERLLAENDKLTKNVSRLEAVFVAPEKHEKeLMGLKSNIAELKKQLSeLNKKCGEGQEKIRALMSE------- 851
Cdd:pfam13166  187 KAalatvfSDNKPEIAPLTFNVIDFDALEKAEILIQK-VIGKSSAIEELIKNPD-LADWVEQGLELHKAHLDTcpfcgqp 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  852 -NSSLKKTLSSQYvpAKTHEEVKASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMKADYV 927
Cdd:pfam13166  265 lPAERKAALEAHF--DDEFTEFQNRLQKLIEKVESAISSLLAQLPavsDLASLLSAFELDVEDIESEAEVLNSQLDGLRR 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  928 SLEEHSRRMSTVSQ---------SLKEAQEANAAILADHrqgqEEIVSLHAEIKAQKK---ELDTIQECiklkYAPLARL 995
Cdd:pfam13166  343 ALEAKRKDPFKSIEldsvdakieSINDLVASINELIAKH----NEITDNFEEEKNKAKkklRLHLVEEF----KSEIDEY 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306  996 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKkgkqenerlradlaALQKELQD 1050
Cdd:pfam13166  415 KDKYAGLEKAINSLEKEIKNLEAEIKKLREEIK--------------ELEAQLRD 455
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-110 8.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 8.21e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306   55 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 110
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
188-235 9.06e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 9.06e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039794306  188 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALG 235
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1102-1254 1.10e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1102 SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSsvtLAEHLKLKE--A 1179
Cdd:COG1579     17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---LGNVRNNKEyeA 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306 1180 LEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASL 1254
Cdd:COG1579     94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 307-1223 1.21e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.96  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  307 EIENEDLREKLRKIQQEQRILLdkvnglqlQLNEEVMVADDLESEREKLKSLLAAKEKQ----HEESLRTIEALKNRfky 382
Cdd:TIGR00606  244 ENELDPLKNRLKEIEHNLSKIM--------KLDNEIKALKSRKKQMEKDNSELELKMEKvfqgTDEQLNDLYHNHQR--- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  383 fESDHPGPGSYPSNRKEDMLHKQGQMYTTE----------PQCASPGIPPHMHSRSMLRpLELSLPSQTSYSENE-ILKK 451
Cdd:TIGR00606  313 -TVREKERELVDCQRELEKLNKERRLLNQEktellveqgrLQLQADRHQEHIRARDSLI-QSLATRLELDGFERGpFSER 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  452 ELETLRTYYDSAKQDRLKFQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 531
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVI 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  532 EHLTNeAATGSHRIIE---ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLvgEFKRDEGRLVEENKRLQKEcGTCEVE 608
Cdd:TIGR00606  461 KELQQ-LEGSSDRILEldqELRKAERELSKAEKNSLTETLKKEVKSLQNEKA--DLDRKLRKLDQEMEQLNHH-TTTRTQ 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  609 LERRGRRVVELEGQLK--------ELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLES 680
Cdd:TIGR00606  537 MEMLTKDKMDKDEQIRkiksrhsdELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  681 VRAQHIRPEEH-------EQLRSRLEQKSGELGKKvseltlknqtlQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRV 753
Cdd:TIGR00606  617 KEEQLSSYEDKlfdvcgsQDEESDLERLKEEIEKS-----------SKQRAMLAGATAVYSQFITQLTDENQSCCPVCQR 685

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  754 SEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSE 833
Cdd:TIGR00606  686 VFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPELRNKLQKVNRDIQR 762

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  834 LNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVK------ASLNSTVEKTN--RALLEAKKRFDDTSQEVSKLR 905
Cdd:TIGR00606  763 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiAQQAAKLQGSDldRTVQQVNQEKQEKQHELDTVV 842

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  906 DENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQeanaailadhrQGQEEIVSLHAEIKAQKKEldtiqecI 985
Cdd:TIGR00606  843 SKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTEVQSLIRE-------I 904

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  986 KLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnalaeEAREAERAL 1065
Cdd:TIGR00606  905 KDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDD-----YLKQKETEL 979

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1066 SGKADELSKQLKDLSQKYSDVKSEREKLveEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKeelrskqrc 1145
Cdd:TIGR00606  980 NTVNAQLEECEKHQEKINEDMRLMRQDI--DTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ--------- 1048

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306 1146 LEREQQTVSQLQQLLENQKNSSVTLAEHLKlkeALEKEVGIMKASLREKeeESQKKTKEVSKLQTEVQTTKQALKNLE 1223
Cdd:TIGR00606 1049 VLQMKQEHQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVMRTTELVNKDLD 1121
Ank_4 pfam13637
Ankyrin repeats (many copies);
36-86 1.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039794306   36 YDDRLMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECL 86
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVL 50
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 769-1204 1.64e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.30  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  769 NKKLSEATQRYTEKKQ-EAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKira 847
Cdd:pfam18971  412 NTKLDNLSEKEKEKFQnEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDR--- 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  848 lmSENSSLKKTLSSQ---YVPAKTHEEVKASLNST--VEKTNR-ALLEAKkrFDDTSqeVSKLRDENEV-----LRRNLE 916
Cdd:pfam18971  489 --EKNVTLQGSLKHDgvmFVDYSNFKYTNASKNPNkgVGATNGvSHLEAG--FNKVA--VFNLPDLNNLaitsfVRRNLE 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  917 NvqnQMKADYVSLEEHSRRMSTVSQSLKEAqeANAAILADHRQGQEEIVSLHAEIKAQKKELD-TIQECIKLKyaplarl 995
Cdd:pfam18971  563 N---KLTAKGLSLQEANKLIKDFLSSNKEL--AGKALNFNKAVAEAKSTGNYDEVKKAQKDLEkSLRKREHLE------- 630

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  996 EECERKFKaTEKGLKEQLSEQTHKCRQRDEEVKK-GKQENERLRA-----DLAALQKELQDrnalaeeareaeralsgKA 1069
Cdd:pfam18971  631 KEVEKKLE-SKSGNKNKMEAKAQANSQKDEIFALiNKEANRDARAiaytqNLKGIKRELSD-----------------KL 692

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1070 DELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN----------GTIEQLKEEL 1139
Cdd:pfam18971  693 EKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNefkngknkdfSKVTQAKSDL 772

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306 1140 RSKQRCLEREQQTVSQLQQLlenqkNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKE 1204
Cdd:pfam18971  773 ENSVKDVIINQKVTDKVDNL-----NQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNED 832
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-262 1.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  119 LQKLLQY--NCPTEHVDlQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGAD-- 194
Cdd:PHA02874    17 IEKIIKNkgNCINISVD-ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDts 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  195 ---------------------VNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNL 253
Cdd:PHA02874    96 ilpipciekdmiktildcgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                          170
                   ....*....|.
gi 1039794306  254 L--KTASENTN 262
Cdd:PHA02874   176 LleKGAYANVK 186
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 168-200 1.80e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039794306  168 DGRTPLVLATQMC-RPTICQLLIDRGADVNSRDK 200
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 490-1049 1.81e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.25  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  490 RVKEDSdEQIKQLEDAlkdvqkrmYESEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGK 569
Cdd:pfam05483  216 KLKEDH-EKIQHLEEE--------YKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  570 LRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECgtcEVELERRGRRVVELEGQLKELG-AKLALSVPTEKFESMKSSLSN 648
Cdd:pfam05483  287 LIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL---QIATKTICQLTEEKEAQMEELNkAKAAHSFVVTEFEATTCSLEE 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  649 DINEKVKRLaevgrdyESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLEQKSGELGKKVSE---LTLKNQTLQKDVEK 725
Cdd:pfam05483  364 LLRTEQQRL-------EKNEDQLKIITMELQKKSSEL---EEMTKFKNNKEVELEELKKILAEdekLLDEKKQFEKIAEE 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  726 LHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEA 805
Cdd:pfam05483  434 LKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  806 vfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpaktHEEVKASLNSTVEKTNR 885
Cdd:pfam05483  514 ----------ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQK------GDEVKCKLDKSEENARS 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  886 ALLEA-----------------KKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQE 948
Cdd:pfam05483  578 IEYEVlkkekqmkilenkcnnlKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIID 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  949 ANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKL----KYAPLARLEECERkfKATEKGLKEQLSE-QTHKCRQR 1023
Cdd:pfam05483  658 NYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKrcqhKIAEMVALMEKHK--HQYDKIIEERDSElGLYKNKEQ 735

                          570       580
                   ....*....|....*....|....*...
gi 1039794306 1024 DEEVKKGKQENE--RLRADLAALQKELQ 1049
Cdd:pfam05483  736 EQSSAKAALEIElsNIKAELLSLKKQLE 763
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-141 1.86e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 1.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306   89 ILTHG-IDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALH 141
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 767-1273 1.93e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  767 DLNKKLSEATQRYTEKKQEAerlLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcGEGQEKIR 846
Cdd:COG5185    111 NYEWSADILISLLYLYKSEI---VALKDELIKVEKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKK-LEIFGLTL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  847 ALMSENSSLKKTLSSQYVPAK----THEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQM 922
Cdd:COG5185    187 GLLKGISELKKAEPSGTVNSIkeseTGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLR 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  923 KADYVSLEEHSRRMStvsqslkeaqEANAAILADHRQGQEEIVSLHAEIKAQKKeldtiQECIKLKYAPLARLEECERKF 1002
Cdd:COG5185    267 LEKLGENAESSKRLN----------ENANNLIKQFENTKEKIAEYTKSIDIKKA-----TESLEEQLAAAEAEQELEESK 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1003 KATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRAdlaalqkelqdrnalaeeareaeralsgkadelSKQLKDLSQK 1082
Cdd:COG5185    332 RETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVG---------------------------------EVELSKSSEE 378

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1083 YSDVKSEREKLVEEkakqasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclEREQQTVSQLQQLLEN 1162
Cdd:COG5185    379 LDSFKDTIESTKES------LDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQA----TSSNEEVSKLLNELIS 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1163 QKNSSVTLAEHLKLKEALEKEVGIMkaslREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVdmsKYKATKNDLET 1242
Cdd:COG5185    449 ELNKVMREADEESQSRLEEAYDEIN----RSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLER---QLEGVRSKLDQ 521

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1039794306 1243 QISNLNDKLASLNRKYDQACEEKVSAKDEKE 1273
Cdd:COG5185    522 VAESLKDFMRARGYAHILALENLIPASELIQ 552
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 809-1050 1.97e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.69  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  809 APEKHEK-ELMGLKSNIAELKKQLSELN------KKCGEGQEKIRALMSENSSLKKTLS--SQYVPA-----KTHEEVK- 873
Cdd:PRK05771     2 APVRMKKvLIVTLKSYKDEVLEALHELGvvhiedLKEELSNERLRKLRSLLTKLSEALDklRSYLPKlnplrEEKKKVSv 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  874 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY-VSLEEHSRRMSTVSQSLKEAQEANAa 952
Cdd:PRK05771    82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLdLSLLLGFKYVSVFVGTVPEDKLEEL- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  953 iladhrqgQEEIVSLHAEIKAQKKELDTI-----QECIKLKYAPLARLEEceRKFKATEKGLkeqLSEQTHKCRQRDEEV 1027
Cdd:PRK05771   161 --------KLESDVENVEYISTDKGYVYVvvvvlKELSDEVEEELKKLGF--ERLELEEEGT---PSELIREIKEELEEI 227

                          250       260
                   ....*....|....*....|...
gi 1039794306 1028 KKgkqENERLRADLAALQKELQD 1050
Cdd:PRK05771   228 EK---ERESLLEELKELAKKYLE 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
521-740 1.97e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  521 KQMQTHFLALKEHLTNeaATGSHRIIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEE 594
Cdd:COG4913    221 PDTFEAADALVEHFDD--LERAHEALEDAREQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELE 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  595 N-----KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQG 669
Cdd:COG4913    299 ElraelARLEAELERLEARLDALREELDELEAQIRGNGGDR------------LEQLEREIERLERELEERERRRARLEA 366

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306  670 EIRQLK-------RDLESVRAQ-HIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSL 740
Cdd:COG4913    367 LLAALGlplpasaEEFAALRAEaAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL 445
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 907-1297 2.03e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  907 ENEVLRRNLENVQNQMKADYVSLEEHSRRMStvSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK 986
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEKFEKME--QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  987 LKYAPLARLEECERKfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAAlqkelqdrnalaeeareaerals 1066
Cdd:pfam17380  345 ERERELERIRQEERK-RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEA----------------------- 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1067 gkadelskqlkdlSQKYSDVKSEREKLVEEKAKQASEILAAQ-NLLQKQPVPLEQvealkkslngtiEQLKEELRSKQRC 1145
Cdd:pfam17380  401 -------------ARKVKILEEERQRKIQQQKVEMEQIRAEQeEARQREVRRLEE------------ERAREMERVRLEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 LEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETR 1225
Cdd:pfam17380  456 QERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERR 535

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794306 1226 EVVDMSKYKATKNDLETQISNlNDKLASLNRKYDQACEEkvsakdEKELLHLSIEQEIRDQKERCDKSLTTI 1297
Cdd:pfam17380  536 REAEEERRKQQEMEERRRIQE-QMRKATEERSRLEAMER------EREMMRQIVESEKARAEYEATTPITTI 600
Ank_5 pfam13857
Ankyrin repeats (many copies);
122-176 2.19e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 2.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306  122 LLQY-NCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLA 176
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 929-1169 2.24e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 2.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  929 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEeceRKFKATEKG 1008
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1009 LKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREaeralsgKADELSKQLKDLSQKYSDVKS 1088
Cdd:COG4942    106 LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA-------DLAELAALRAELEAERAELEA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1089 EREKLVEEKAKQASEILAAQNLLQKqpvpleqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1168
Cdd:COG4942    179 LLAELEEERAALEALKAERQKLLAR--------------LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                   .
gi 1039794306 1169 T 1169
Cdd:COG4942    245 A 245
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 108-188 2.40e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  108 HLAAKyGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 187
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1039794306  188 L 188
Cdd:PTZ00322   167 L 167
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 962-1351 2.42e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  962 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1041
Cdd:pfam02463  160 EEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1042 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQV 1121
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSE--------------LLKL 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1122 EALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimKASLREKEEESQKK 1201
Cdd:pfam02463  306 ERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEK----LEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1202 TKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQ 1281
Cdd:pfam02463  382 ESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL 461

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1282 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQ 1351
Cdd:pfam02463  462 KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRL 531
mukB PRK04863
chromosome partition protein MukB;
451-1269 2.67e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.72  E-value: 2.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  451 KELETLRTYYDSAkqDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 530
Cdd:PRK04863   260 KHLITESTNYVAA--DYMRHANERRVHLEE----ALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAA 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  531 KEHLT----------------------NEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK--QSEMLVGEFK- 585
Cdd:PRK04863   334 SDHLNlvqtalrqqekieryqadleelEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLAdyQQALDVQQTRa 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  586 ---RDEGRLVEENKRLqkeCGTCEVELERRGRRVVELEGQLKELGAKLaLSVPTekfesmKSSLSNDINEK-------VK 655
Cdd:PRK04863   414 iqyQQAVQALERAKQL---CGLPDLTADNAEDWLEEFQAKEQEATEEL-LSLEQ------KLSVAQAAHSQfeqayqlVR 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  656 RLA-EVGRdyESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLeqksgelgkkvseltlknQTLQKDVEKLHADNKLLN 734
Cdd:PRK04863   484 KIAgEVSR--SEAWDVARELLRRLREQRHL---AEQLQQLRMRL------------------SELEQRLRQQQRAERLLA 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  735 Q--QVHSLTVEMKTRYvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKN----------VSR 802
Cdd:PRK04863   541 EfcKRLGKNLDDEDEL------EQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARapawlaaqdaLAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  803 LEAVFvaPEK----------------HEKELM----GLKSNIAELKKQLSELNKKCGEGQEKIRALMS-----------E 851
Cdd:PRK04863   615 LREQS--GEEfedsqdvteymqqlleRERELTverdELAARKQALDEEIERLSQPGGSEDPRLNALAErfggvllseiyD 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  852 NSSLKKT--LSSQYVPAKtHEEVKASLNSTVEKtnralLEAkkrFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSL 929
Cdd:PRK04863   693 DVSLEDApyFSALYGPAR-HAIVVPDLSDAAEQ-----LAG---LEDCPEDLYLIEGDPDSFDDSVFSVEELEKAVVVKI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  930 EEHSRRMS---TVSQSLKEAQEANAAILadhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYA----------PLARLE 996
Cdd:PRK04863   764 ADRQWRYSrfpEVPLFGRAAREKRIEQL---RAEREELAERYATLSFDVQKLQRLHQAFSRFIGshlavafeadPEAELR 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  997 ECERKFKATEKGLkEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKE-LQDRnalaeeareaeralsgkADELSKQ 1075
Cdd:PRK04863   841 QLNRRRVELERAL-ADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADEtLADR-----------------VEEIREQ 902

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1076 LKDLSQKYSDVKSEreklveekAKQASEILAAQNLLQKQPvplEQVEALKKSLngtiEQLKEELR-SKQRCL-------E 1147
Cdd:PRK04863   903 LDEAEEAKRFVQQH--------GNALAQLEPIVSVLQSDP---EQFEQLKQDY----QQAQQTQRdAKQQAFaltevvqR 967

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1148 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtREV 1227
Cdd:PRK04863   968 RAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRA---REQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELK-QEL 1043

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794306 1228 VDM-----------------------SKYKATKNDLETQIS-------NLNDKLASLNRKYDQACEEKVSAK 1269
Cdd:PRK04863  1044 QDLgvpadsgaeerararrdelharlSANRSRRNQLEKQLTfceaemdNLTKKLRKLERDYHEMREQVVNAK 1115
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 682-1227 2.91e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.50  E-value: 2.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  682 RAQHIRPEEH-EQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 760
Cdd:pfam05557    1 RAELIESKARlSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  761 HDVNVEDLNKKLSEATQRYTEKKqeaERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 840
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQLADAR---EVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  841 GQEKIRALMSENSSLKK---TLSSQYVPAKTHEEVKASLNS--TVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL 915
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKElefEIQSQEQDSEIVKNSKSELARipELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  916 ENvQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARL 995
Cdd:pfam05557  238 ER-EEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARREL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  996 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEareaeralSGKADELSKQ 1075
Cdd:pfam05557  317 EQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQL--------LERIEEAEDM 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1076 LKDLSQKYSDVKSEREKLVEEKAKQAS---------EILAAQNLLQKQPVPLEQVEALKKSLNgTIEQLKEELRSKQRCL 1146
Cdd:pfam05557  389 TQKMQAHNEEMEAQLSVAEEELGGYKQqaqtlerelQALRQQESLADPSYSKEEVDSLRRKLE-TLELERQRLREQKNEL 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1147 EREQQTVSqLQQLLENQKNSSVTLAEHLKLK---------EALEKEVGIMKASLREKEEESQK-----------KTKEVS 1206
Cdd:pfam05557  468 EMELERRC-LQGDYDPKKTKVLHLSMNPAAEayqqrknqlEKLQAEIERLKRLLKKLEDDLEQvlrlpettstmNFKEVL 546

                          570       580
                   ....*....|....*....|.
gi 1039794306 1207 KLQTEVQTTKqaLKNLETREV 1227
Cdd:pfam05557  547 DLRKELESAE--LKNQRLKEV 565
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1032-1376 3.12e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1032 QENERLRADLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQnlL 1111
Cdd:COG4913    606 FDNRAKLAALEAELAELEEE-----------------LAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAS--A 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1112 QKQpvpLEQVEALKKSL---NGTIEQLK---EELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLK--LKEALEKE 1183
Cdd:COG4913    667 ERE---IAELEAELERLdasSDDLAALEeqlEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrLEAAEDLA 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1184 VGIMKASLREK--EEESQKKTKEVSK-LQTEVQTTKQALKNLETREVVDMSKYKAT----KNDLETQISNLNDKLASLNR 1256
Cdd:COG4913    744 RLELRALLEERfaAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAFNREwpaeTADLDADLESLPEYLALLDR 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1257 KYDQACEEKVsaKDEKELLHLSIEQEIRDqkercdkslttimeLQQRIQESAKQIEakdnkitellndvERLKQaLN-GL 1335
Cdd:COG4913    824 LEEDGLPEYE--ERFKELLNENSIEFVAD--------------LLSKLRRAIREIK-------------ERIDP-LNdSL 873

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1039794306 1336 SQLTYSSGS-----PTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1376
Cdd:COG4913    874 KRIPFGPGRylrleARPRPDPEVREFRQELRAVTSGASLFDEELSE 919
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-166 3.55e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 3.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039794306  135 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 166
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
449-853 3.84e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 3.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  449 LKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERvkEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFL 528
Cdd:COG4717     93 LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL--EALEAELAELPERLEELEERLEELRELEEELEELEA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  529 ALKEhLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEcgtceve 608
Cdd:COG4717    171 ELAE-LQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  609 lerrgRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH-IR 687
Cdd:COG4717    243 -----ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEeLE 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  688 PEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSltvemktryvpLRVSEEMKKSHDVNVED 767
Cdd:COG4717    318 EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-----------QEIAALLAEAGVEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  768 LNKKLsEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA 847
Cdd:COG4717    387 LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALD-EEELEEELEELEEELEELEEELEELREELAELEAELEQ 464


                   ....*.
gi 1039794306  848 LMSENS 853
Cdd:COG4717    465 LEEDGE 470
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 473-1160 4.36e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.83  E-value: 4.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  473 ELAHKVAECKALA-LECERVKEDSDEQ-IKQLEDALKdvqkRMYESEGKVKQMQThflaLKEHLTNEAATGSHRIIEELR 550
Cdd:pfam12128  222 QVEHWIRDIQAIAgIMKIRPEFTKLQQeFNTLESAEL----RLSHLHFGYKSDET----LIASRQEERQETSAELNQLLR 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  551 EQLKDLKGKYEGASAEVGKLRSQIKQsemlvgefKRDEGRLVEENKR--LQKECGTCEVELERRGRRVVELEGQLKELGA 628
Cdd:pfam12128  294 TLDDQWKEKRDELNGELSAADAAVAK--------DRSELEALEDQHGafLDADIETAAADQEQLPSWQSELENLEERLKA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  629 KL-ALSVPTEKFESMKSSLSNDINEKVKRLAE--------VGRDYESAQGEIRQLKRDLESVRAQHIRP--EEHEQLRSR 697
Cdd:pfam12128  366 LTgKHQDVTAKYNRRRSKIKEQNNRDIAGIKDklakireaRDRQLAVAEDDLQALESELREQLEAGKLEfnEEEYRLKSR 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  698 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKL--LNQQVHSLTVEmktryvpLRVSEEMKKSHDVNVEDLNKKLSEA 775
Cdd:pfam12128  446 LGELKLRLNQATATPELLLQLENFDERIERAREEQeaANAEVERLQSE-------LRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  776 TQRYTEKKQ----EAERLLA--------ENDKLTKNVSR--LEAVFVAPEKHEKELMGlKSNIAELKKQLSELNKKCGEG 841
Cdd:pfam12128  519 QSALDELELqlfpQAGTLLHflrkeapdWEQSIGKVISPelLHRTDLDPEVWDGSVGG-ELNLYGVKLDLKRIDVPEWAA 597

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  842 QEKirALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL---------- 911
Cdd:pfam12128  598 SEE--ELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkknkalae 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  912 --------RRNLENVQNQMKADYVSLEEHSRRMS-----TVSQSLKEAQEANAAILADHRQGQE-EIVSLHAEIKAQKKE 977
Cdd:pfam12128  676 rkdsanerLNSLEAQLKQLDKKHQAWLEEQKEQKreartEKQAYWQVVEGALDAQLALLKAAIAaRRSGAKAELKALETW 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  978 LDT--------------IQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKcrqRDEEVKKGKQENERLRADLAA 1043
Cdd:pfam12128  756 YKRdlaslgvdpdviakLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPR---LATQLSNIERAISELQQQLAR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1044 LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREklVEEKAKQASEILAA-QNLLQKQPVPLEQVE 1122
Cdd:pfam12128  833 LIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDAN--SEQAQGSIGERLAQlEDLKLKRDYLSESVK 910

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039794306 1123 ALKKSLNGTI------------EQLKEELRS---KQRCLEREQQTVSQLQQLL 1160
Cdd:pfam12128  911 KYVEHFKNVIadhsgsglaetwESLREEDHYqndKGIRLLDYRKLVPYLEQWF 963
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 766-1001 4.45e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 4.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  766 EDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekelmglksNIAELKKQLSELNKKCGEGQEKI 845
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-----------------RIAALARRIRALEQELAALEAEL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  846 RALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNR----ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 921
Cdd:COG4942     86 AELEKEIAELRAELEAQ-------KEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  922 MKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK 1001
Cdd:COG4942    159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
490-705 5.01e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 5.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  490 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQmqthflalkehltneaatgshriIEELREQLKDLKGKYEGASAEVGK 569
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEKEEEYAELQEE-----------------------LEELEEELEELEAELEELREELEK 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  570 LRsQIKQSEMLVGEFKRDEGRLVEENKRLQkecgtcevELERRGRRVVELEGQLKELGAKLAlsvptEKFESMKSSLSND 649
Cdd:COG4717    121 LE-KLLQLLPLYQELEALEAELAELPERLE--------ELEERLEELRELEEELEELEAELA-----ELQEELEELLEQL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306  650 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGEL 705
Cdd:COG4717    187 SLATEEELQDLAEELEELQQRLAELEEELEEAQ------EELEELEEELEQLENEL 236
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1074-1335 5.02e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 5.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1074 KQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL-EQVEALKKSLNgTIEQLKEELRSKQRCLEREQQT 1152
Cdd:PRK03918   175 KRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELrEELEKLEKEVK-ELEELKEEIEELEKELESLEGS 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1153 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkaslrekeEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmSK 1232
Cdd:PRK03918   254 KRKLEEKIRELEERIEELKKEIEELEEKVKEL-----------KELKEKAEEYIKLSEFYEEYLDELREIEKRL----SR 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1233 YKATKNDLETQISNLNDKLASLN--RKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSLT---------TIMELQ 1301
Cdd:PRK03918   319 LEEEINGIEERIKELEEKEERLEelKKKLKELEKRLEELEERHELYEEAKA-KKEELERLKKRLTgltpeklekELEELE 397

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1039794306 1302 QRIQESAKQIEAKDNKITELLNDVERLKQALNGL 1335
Cdd:PRK03918   398 KAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 5.26e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 5.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   81 GNLECLNAILTHgiDVATRDSAGRNALHLAAKYGH-------ALCLQKLLQYNCPTEHVD-------LQGRTALHDAAMA 146
Cdd:cd21882      6 GLLECLRWYLTD--SAYQRGATGKTCLHKAALNLNdgvneaiMLLLEAAPDSGNPKELVNapctdefYQGQTALHIAIEN 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306  147 DCPSSIQLLCDHGASVNAKDID-------------GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQN 202
Cdd:cd21882     84 RNLNLVRLLVENGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAQD 152
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 597-1226 5.33e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.78  E-value: 5.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  597 RLQKECGTCEVELERRGRRVVELEGQLKELGAKLA------------LSVPTEKF---ESMKSSLSNdineKVKRLAEVG 661
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQqlceeknalqeqLQAETELCaeaEEMRARLAA----RKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  662 RDYESAQGEIRQLKRDLESVR---AQHIRP-----EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLL 733
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKkkmQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  734 NQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLseatqryteKKQEAERLlaendKLTKNVSRLEAvfvapekh 813
Cdd:pfam01576  158 EERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL---------KKEEKGRQ-----ELEKAKRKLEG-------- 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  814 ekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS--------ENSSLKKTLSSQYVPAKTHEEVKAslnstvEKTNR 885
Cdd:pfam01576  216 --ESTDLQEQIAELQAQIAELRAQLAKKEEELQAALArleeetaqKNNALKKIRELEAQISELQEDLES------ERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  886 ALLEAKKRfddtsqevsKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQgqeeiv 965
Cdd:pfam01576  288 NKAEKQRR---------DLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQ------ 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  966 slhaeikAQKKELDTIQEciklkyaplaRLEECERKFKATEKGlKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1045
Cdd:pfam01576  353 -------KHTQALEELTE----------QLEQAKRNKANLEKA-KQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1046 KELQDRNALAEEAREAERALSGKadeLSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ---KQPVPL-EQV 1121
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSK---LQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQeetRQKLNLsTRL 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1122 EALKKSLNGTIEQLKEELRSKQRcLEREQQTV-SQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQK 1200
Cdd:pfam01576  492 RQLEDERNSLQEQLEEEEEAKRN-VERQLSTLqAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDK 570

                          650       660       670
                   ....*....|....*....|....*....|...
gi 1039794306 1201 KTKEVSKLQTE-------VQTTKQALKNLETRE 1226
Cdd:pfam01576  571 LEKTKNRLQQElddllvdLDHQRQLVSNLEKKQ 603
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1140-1335 5.61e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 5.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1140 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQAL 1219
Cdd:COG1579      3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1220 KNLET-REVVDMSK----YKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksl 1294
Cdd:COG1579     83 GNVRNnKEYEALQKeiesLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE----- 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1039794306 1295 ttIMELQQRIQESAKQIEAkdnkitELLNDVERLKQALNGL 1335
Cdd:COG1579    158 --LEELEAEREELAAKIPP------ELLALYERIRKRKNGL 190
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 769-1331 5.67e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.66  E-value: 5.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  769 NKKLSEATQRYTEKK-QEAERLLAENDKLTKNVSRLE-AVFVAPEKHEKELMGLKSNIAELKKQLSEL-------NKKCG 839
Cdd:TIGR01612  524 NIIGFDIDQNIKAKLyKEIEAGLKESYELAKNWKKLIhEIKKELEEENEDSIHLEKEIKDLFDKYLEIddeiiyiNKLKL 603

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  840 EGQEKIRALMSENSSLKKTLSSQYV---------------PAKTHEEVKA--SLNSTVEKTNRALLEAKkrFDDTSQEVS 902
Cdd:TIGR01612  604 ELKEKIKNISDKNEYIKKAIDLKKIiennnayidelakisPYQVPEHLKNkdKIYSTIKSELSKIYEDD--IDALYNELS 681

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  903 KLRDENEVlrrnlENVQNQMKadyvsLEEHSRRMSTVSQSLKEAqeanaailadhrqgQEEIVSLH-AEIKAQKKEL-DT 980
Cdd:TIGR01612  682 SIVKENAI-----DNTEDKAK-----LDDLKSKIDKEYDKIQNM--------------ETATVELHlSNIENKKNELlDI 737

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  981 IQECIKLKYAPLAR-LEECERKFKATEKGLKEQLS------EQTHKCRQRDEEVKkgKQENERLRADlaalQKELQDRNA 1053
Cdd:TIGR01612  738 IVEIKKHIHGEINKdLNKILEDFKNKEKELSNKINdyakekDELNKYKSKISEIK--NHYNDQINID----NIKDEDAKQ 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1054 LAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLV------EEKAKQASEILAAQNLLQKQPVPLEQVEALKKS 1127
Cdd:TIGR01612  812 NYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFInfenncKEKIDSEHEQFAELTNKIKAEISDDKLNDYEKK 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1128 LNGTIEQLKEELRSkqrcLEREQQTVSQLQ------QLLENQKNSSVTL-AEHLKLKEALEKEVGIMKAS-LREKEEESQ 1199
Cdd:TIGR01612  892 FNDSKSLINEINKS----IEEEYQNINTLKkvdeyiKICENTKESIEKFhNKQNILKEILNKNIDTIKESnLIEKSYKDK 967

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1200 KKTKEVSKLqTEVQttkQALKNLEtrevvdMSKYKATKNDLETQISNLNDKLASL--NRKYDQAceekvsakDEKELLHL 1277
Cdd:TIGR01612  968 FDNTLIDKI-NELD---KAFKDAS------LNDYEAKNNELIKYFNDLKANLGKNkeNMLYHQF--------DEKEKATN 1029

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306 1278 SIEQEIRDqkerCDKSLTTI-MELQQRIQESAKQIEAKDNKITELLNDvERLKQA 1331
Cdd:TIGR01612 1030 DIEQKIED----ANKNIPNIeIAIHTSIYNIIDEIEKEIGKNIELLNK-EILEEA 1079
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
694-923 6.06e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 6.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  694 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKlhADNKLlnqqvhsltVEMKTRYVPLRVSEEMKkSHDVNVEDLNKKLS 773
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQLPELRKELEE--AEAAL---------EEFRQKNGLVDLSEEAK-LLLQQLSELESQLA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  774 EATQRYTEKKQEAERLlaeNDKLTKNVSRLEAVFVAPEkhekeLMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENS 853
Cdd:COG3206    230 EARAELAEAEARLAAL---RAQLGSGPDALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA 301

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039794306  854 SLKKTLSSQYVPAKTHEEVK-ASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMK 923
Cdd:COG3206    302 ALRAQLQQEAQRILASLEAElEALQAREASLQAQLAQLEARLAelpELEAELRRLEREVEVARELYESLLQRLE 375
PRK11281 PRK11281
mechanosensitive channel MscK;
1236-1373 6.33e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1236 TKNDLETQISNLNDklaslnRKYDQAcEEKVSAKD-EKELLHLsieQEIRDQKERCDkslttimELQQRIQESakqieak 1314
Cdd:PRK11281    37 TEADVQAQLDALNK------QKLLEA-EDKLVQQDlEQTLALL---DKIDRQKEETE-------QLKQQLAQA------- 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1315 DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQrVRDLQQQLADADRQ 1373
Cdd:PRK11281    93 PAKLRQAQAELEALKDDNDEETRETLSTLSLRQLESRLAQTLDQ-LQNAQNDLAEYNSQ 150
46 PHA02562
endonuclease subunit; Provisional
 1130-1332 6.47e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 6.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1130 GTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQknssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1209
Cdd:PHA02562   163 SVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQ------IKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEI 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1210 TEVQTtkqALKNLetreVVDMSKYKATKNDLETQISNLNDKLASLNRKYD--------QACEEKVSAKDEKEllhlsieQ 1281
Cdd:PHA02562   237 EELTD---ELLNL----VMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcPTCTQQISEGPDRI-------T 302

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039794306 1282 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQAL 1332
Cdd:PHA02562   303 KIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353
PRK11281 PRK11281
mechanosensitive channel MscK;
821-1041 6.77e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 6.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  821 KSNIAELKKQLSELNKKCGEGQEKIRALMSEN-SSLKKTLSSQYVPaktheevkaSLNSTVEKTNRALLEAKKRFDDT-S 898
Cdd:PRK11281    79 KEETEQLKQQLAQAPAKLRQAQAELEALKDDNdEETRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYnS 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  899 QEVSklrdenevLRRNLENVQNQMKADyvsleehSRRMSTVSQSLKEAQEANAAILADHRQG-QEEIVSLHAEIKAQKKE 977
Cdd:PRK11281   150 QLVS--------LQTQPERAQAALYAN-------SQRLQQIRNLLKGGKVGGKALRPSQRVLlQAEQALLNAQNDLQRKS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  978 L---DTIQECIKLKY----APLARLEE---------CERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1041
Cdd:PRK11281   215 LegnTQLQDLLQKQRdyltARIQRLEHqlqllqeaiNSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRL 294
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1021-1237 7.13e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 7.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1021 RQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQ 1100
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI----EERREELGERARA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1101 ASE----------ILAAQN---LLQKQPVpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSS 1167
Cdd:COG3883     95 LYRsggsvsyldvLLGSESfsdFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039794306 1168 VT-LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1237
Cdd:COG3883    174 EAqQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 244
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1068-1339 8.42e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS--EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRC 1145
Cdd:PTZ00440   451 KINELKKSINQLKTLISIMKSFYDLIISEKDSMDSkeKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKNIEDYYIT 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 LEREQQTVSQLQQLLENQKNSSVTLAEHlklkealEKEVGIMKASLREK---EEESQKKTKEVSKLQTEVQTTKQALKNL 1222
Cdd:PTZ00440   531 IEGLKNEIEGLIELIKYYLQSIETLIKD-------EKLKRSMKNDIKNKikyIEENVDHIKDIISLNDEIDNIIQQIEEL 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1223 ETREVVDMSKYKATKNDLETQISNLNDK------------LASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERC 1290
Cdd:PTZ00440   604 INEALFNKEKFINEKNDLQEKVKYILNKfykgdlqelldeLSHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKS 683

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1039794306 1291 DKSLTTIMELQqriQESAKQIEAKDNKITELLNDVErlKQALNGLSQLT 1339
Cdd:PTZ00440   684 DNIDNIIKNLK---KELQNLLSLKENIIKKQLNNIE--QDISNSLNQYT 727
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
774-1258 8.78e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 8.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  774 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnkkcgegQEKIRALmsens 853
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-------REELEKL----- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  854 slkKTLSSQYVPAKTHEEVKASLNSTVEKTNRaLLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADyvsleehs 933
Cdd:COG4717    122 ---EKLLQLLPLYQELEALEAELAELPERLEE-LEERLEELRELEEELEELEAELAELQEELEELLEQLSLA-------- 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  934 rrmstVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEcIKLKYAPLARLEECERKFKATekGLKEQL 1013
Cdd:COG4717    190 -----TEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEN-ELEAAALEERLKEARLLLLIA--AALLAL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1014 SEQTHKCRQRDEEVKKGKQENERLRADLAA-LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1092
Cdd:COG4717    262 LGLGGSLLSLILTIAGVLFLVLGLLALLFLlLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1093 L---VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQtVSQLQQLLENQKNSSVT 1169
Cdd:COG4717    342 LldrIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEE-LEELEEQLEELLGELEE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1170 LAEHLKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykatknDLETQISNLND 1249
Cdd:COG4717    421 LLEALDEEELEEE--------LEELEEELEELEEELEELREELAELEAELEQLEEDGELA---------ELLQELEELKA 483


                   ....*....
gi 1039794306 1250 KLASLNRKY 1258
Cdd:COG4717    484 ELRELAEEW 492
PRK01156 PRK01156
chromosome segregation protein; Provisional
 722-1274 9.34e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.74  E-value: 9.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  722 DVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS 801
Cdd:PRK01156   160 EINSLERNYDKLKDVIDMLRAEISN----IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYN 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  802 RLEAVFVAPEKHEKELMGLKSNIAELKKQLS---ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTH--------E 870
Cdd:PRK01156   236 NLKSALNELSSLEDMKNRYESEIKTAESDLSmelEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDienkkqilS 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  871 EVKASLN---------STVEKTNRALLEAKKRFDDTSQEVSKLR---DENEVLRRNLENVQNQMKADYVSLEEHSRRMST 938
Cdd:PRK01156   316 NIDAEINkyhaiikklSVLQKDYNDYIKKKSRYDDLNNQILELEgyeMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  939 VSQSLKEAQEANAAILADHRQGQEEI----VSLHAEIKAQKKELDTIQECIKL----KYAPLARLEECERKFKATEKGLK 1010
Cdd:PRK01156   396 ILKIQEIDPDAIKKELNEINVKLQDIsskvSSLNQRIRALRENLDELSRNMEMlngqSVCPVCGTTLGEEKSNHIINHYN 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1011 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1090
Cdd:PRK01156   476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1091 EKL----VEEKAKQASEILAAQNLLQKQPVPlEQVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQLQQLLENQ 1163
Cdd:PRK01156   556 KSLkledLDSKRTSWLNALAVISLIDIETNR-SRSNEIKKQLNDLESRLQEieiGFPDDKSYIDKSIREIENEANNLNNK 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1164 KNssvtLAEHLK-LKEALEKEVGIMKASLREKEEeSQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLET 1242
Cdd:PRK01156   635 YN----EIQENKiLIEKLRGKIDNYKKQIAEIDS-IIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRT 709

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039794306 1243 QISNLNDKLASLNRKYDQACEEKVSAKDEKEL 1274
Cdd:PRK01156   710 RINELSDRINDINETLESMKKIKKAIGDLKRL 741
PHA02798 PHA02798
ankyrin-like protein; Provisional
 152-228 1.03e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  152 IQLLCDHGASVNAKDIDGRTPL--VLATQ-MCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLVKNG 225
Cdd:PHA02798    92 VKILIENGADINKKNSDGETPLycLLSNGyINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKG 171


                   ...
gi 1039794306  226 ADL 228
Cdd:PHA02798   172 VDI 174
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 294-1048 1.05e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.88  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  294 QREQRE-PHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLN--EEVMVADDLE------------------SER 352
Cdd:TIGR00606  311 QRTVREkERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDSLiqslatrleldgfergpfSER 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  353 EkLKSLLAAKEKQHEESLRTIEALKNRFK-----------YFESDHPGPGSYPSNRKEDMLHKQGQM--YTTEPQCASPG 419
Cdd:TIGR00606  391 Q-IKNFHTLVIERQEDEAKTAAQLCADLQskerlkqeqadEIRDEKKGLGRTIELKKEILEKKQEELkfVIKELQQLEGS 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  420 IPPHMHSRSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALA--LECERVKEDSDE 497
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTqmEMLTKDKMDKDE 549

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  498 QI-----------------------------------KQLEDALKDVQKRMYESEgkvkQMQTHFLALKEHLTNEAATGS 542
Cdd:TIGR00606  550 QIrkiksrhsdeltsllgyfpnkkqledwlhskskeiNQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSYE 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  543 HRIIEELREQlkDLKGKYEGASAEVGKLRsqiKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEvelerrgrRVVELEGQ 622
Cdd:TIGR00606  626 DKLFDVCGSQ--DEESDLERLKEEIEKSS---KQRAMLAGATAVYSQFITQLTDENQSCCPVCQ--------RVFQTEAE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  623 LKELGAKL---ALSVPTEkfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRL 698
Cdd:TIGR00606  693 LQEFISDLqskLRLAPDK-----LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKvNRDIQRLKNDI 767

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  699 EQKSGELGKKVSELTLKnQTLQKDVEKLhadnkllnQQVHSLTVEMKTRYVPLrVSEEMKKSHDVNVEDLNKKLSEATQR 778
Cdd:TIGR00606  768 EEQETLLGTIMPEEESA-KVCLTDVTIM--------ERFQMELKDVERKIAQQ-AAKLQGSDLDRTVQQVNQEKQEKQHE 837

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  779 YTEKKQEAErllaENDKLTknvsrleavfvapEKHEKELMGLKSNIAELKK---QLSELNKKCGEGQEKIRALMSENSSL 855
Cdd:TIGR00606  838 LDTVVSKIE----LNRKLI-------------QDQQEQIQHLKSKTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  856 KKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSrr 935
Cdd:TIGR00606  901 IREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETE-- 978

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  936 MSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKyaplarleECERKFKATEKGLKE-QLS 1014
Cdd:TIGR00606  979 LNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELK--------EVEEELKQHLKEMGQmQVL 1050

                          810       820       830
                   ....*....|....*....|....*....|....
gi 1039794306 1015 EQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1048
Cdd:TIGR00606 1051 QMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEI 1084
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 445-685 1.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  445 ENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 524
Cdd:COG1196    261 ELAELEAELEELRLELEELELELEEAQAEEYELLAE----LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  525 THFLALKEHLTNEAAtgshrIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGT 604
Cdd:COG1196    337 EELEELEEELEEAEE-----ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  605 CEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 683
Cdd:COG1196    412 LLERLERLEEELEELEEALAELeEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAA 491


                   ..
gi 1039794306  684 QH 685
Cdd:COG1196    492 RL 493
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1067-1275 1.13e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1067 GKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSkqrcL 1146
Cdd:PRK05771    46 RKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKV--SVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----L 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1147 EREQQTVSQLQQL---LENQKNSSVTLAEHLKLKEALEKEVGImKASLREKEEESQKKTKE-----VSKLQTEVQTT--- 1215
Cdd:PRK05771   120 EQEIERLEPWGNFdldLSLLLGFKYVSVFVGTVPEDKLEELKL-ESDVENVEYISTDKGYVyvvvvVLKELSDEVEEelk 198

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306 1216 KQALKNLETREVVD----MSKYKATKNDLETQISNLNDKLASLNRKYDQ---ACEEKVSA-KDEKELL 1275
Cdd:PRK05771   199 KLGFERLELEEEGTpselIREIKEELEEIEKERESLLEELKELAKKYLEellALYEYLEIeLERAEAL 266
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 874-1071 1.22e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  874 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQE 948
Cdd:COG3883     40 DALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYLdvllgSESFSDFLD 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  949 ANAAILADHRQGQEEIvslhAEIKAQKKELDTIQECIKLKyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK 1028
Cdd:COG3883    120 RLSALSKIADADADLL----EELKADKAELEAKKAELEAK---LAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEA 192

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039794306 1029 KGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE 1071
Cdd:COG3883    193 AAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 447-1227 1.45e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 43.24  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  447 EILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALAleceRVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTH 526
Cdd:pfam01576  359 EELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQ----QAKQDSEHKRKKLEGQLQELQARLSESE-RQRAELAE 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  527 FLAlkeHLTNEaatgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCE 606
Cdd:pfam01576  434 KLS---KLQSE--------LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQ 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  607 VELERRGRRVVELEGQLKELGAKLAlsvptekfesmksslsndinEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHi 686
Cdd:pfam01576  503 EQLEEEEEAKRNVERQLSTLQAQLS--------------------DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQL- 561

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  687 rpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsLTVEMKTryVPLRVSEEMKKSHDVNVE 766
Cdd:pfam01576  562 --EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQ----MLAEEKA--ISARYAEERDRAEAEARE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  767 DLNKKLS--EATQRYTEKKQEAER----LLAENDKLtknVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 840
Cdd:pfam01576  634 KETRALSlaRALEEALEAKEELERtnkqLRAEMEDL---VSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQA 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  841 gqekiralmSENSSLKKTLSSQYVPAK----------THEEVKASLNSTV---------EKTNRAL-LEAKKRFDDTSQE 900
Cdd:pfam01576  711 ---------TEDAKLRLEVNMQALKAQferdlqardeQGEEKRRQLVKQVreleaeledERKQRAQaVAAKKKLELDLKE 781

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  901 -------VSKLRDEnevLRRNLENVQNQMKADYVSLEE-HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIK 972
Cdd:pfam01576  782 leaqidaANKGREE---AVKQLKKLQAQMKDLQRELEEaRASRDEILAQS-KESEKKLKNLEAELLQLQEDLAASERARR 857

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  973 AQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1052
Cdd:pfam01576  858 QAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQ--- 934

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1053 alaeeareaerALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQASEILAAQnllqkqpvpLEQVEalkkslngti 1132
Cdd:pfam01576  935 -----------KSESARQQLERQNKELKAKL----QEMEGTVKSKFKSSIAALEAK---------IAQLE---------- 980

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1133 EQLKEELRSKQ---RCLEREQQTVSQLQQLLENQKNSSVTLAEHLklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1209
Cdd:pfam01576  981 EQLEQESRERQaanKLVRRTEKKLKEVLLQVEDERRHADQYKDQA---EKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057

                          810
                   ....*....|....*...
gi 1039794306 1210 TEVQTTKQALKNLeTREV 1227
Cdd:pfam01576 1058 RELDDATESNESM-NREV 1074
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 971-1312 1.87e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.52  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  971 IKAqKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEqLSEQTHKCRQRDEEVKKGKQEnerlradlaaLQKELQD 1050
Cdd:PRK04778   101 RKA-KHEINEIES----------LLDLIEEDIEQILEELQE-LLESEEKNREEVEQLKDLYRE----------LRKSLLA 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1051 RNALAeeareaeralsGKA-DELSKQLKDLsqkysdvKSEREKLVEEKAK----QASEILAAQ----NLLQKQpvpLEQV 1121
Cdd:PRK04778   159 NRFSF-----------GPAlDELEKQLENL-------EEEFSQFVELTESgdyvEAREILDQLeeelAALEQI---MEEI 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1122 EALKKSLNGTI-EQLkEELRSKQRCLERE------QQTVSQLQQLLENQKNSSVTLAEhLKLKEALEKEVGIMKA----- 1189
Cdd:PRK04778   218 PELLKELQTELpDQL-QELKAGYRELVEEgyhldhLDIEKEIQDLKEQIDENLALLEE-LDLDEAEEKNEEIQERidqly 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1190 SLREKEEESQKK-TKEVSKLQTEVQTTKQALKNL--ETREVvdMSKYKATKNDLETQiSNLNDKLASLNRKYDQACEEKv 1266
Cdd:PRK04778   296 DILEREVKARKYvEKNSDTLPDFLEHAKEQNKELkeEIDRV--KQSYTLNESELESV-RQLEKQLESLEKQYDEITERI- 371

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1039794306 1267 sakDEKELLHlsieQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1312
Cdd:PRK04778   372 ---AEQEIAY----SELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 496-1220 1.94e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  496 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLT------NEAATGSHRII---EELREQLKDLKGKYEGASAE 566
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcAEAEEMRARLAarkQELEEILHELESRLEEEEER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  567 VGKLRSQIKQSEMLVGEFkrdEGRLVEEN---KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMK 643
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDL---EEQLDEEEaarQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL--EERISEFT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  644 SSLSNDiNEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGELGKKVSELT-----LKNQT 718
Cdd:pfam01576  166 SNLAEE-EEKAKSLSKLKNKHEAMISDLEERLKKEEKGR------QELEKAKRKLEGESTDLQEQIAELQaqiaeLRAQL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  719 LQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMkkshdvnvEDLNKKLSEATQRYTEKKQEAERLLAENDKLTK 798
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQ--------EDLESERAARNKAEKQRRDLGEELEALKTELED 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  799 NVSRLEAVFVAPEKHEKELMGLKSNIAELKK----QLSELNKKCGEGQEKI------------------RALMSENSSLK 856
Cdd:pfam01576  311 TLDTTAAQQELRSKREQEVTELKKALEEETRsheaQLQEMRQKHTQALEELteqleqakrnkanlekakQALESENAELQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  857 KTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRM 936
Cdd:pfam01576  391 AEL-------RTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  937 STVSQSLKEAQEanaailadhrQGQEEI---VSLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEK---GLK 1010
Cdd:pfam01576  464 SSLESQLQDTQE----------LLQEETrqkLNLSTRLRQLEDERNSLQE----------QLEEEEEAKRNVERqlsTLQ 523

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1011 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1090
Cdd:pfam01576  524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQ 603

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1091 EK----LVEEKAkqaseiLAAQNLLQKQPVPLEQVEALKKSLNGTIEqLKEELRSKQRCLEREQQTVSQLQQLLENQKNS 1166
Cdd:pfam01576  604 KKfdqmLAEEKA------ISARYAEERDRAEAEAREKETRALSLARA-LEEALEAKEELERTNKQLRAEMEDLVSSKDDV 676

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306 1167 SVTLAEHLKLKEALEKEVGIMKASLREKEEESQkkTKEVSKLQTEVqtTKQALK 1220
Cdd:pfam01576  677 GKNVHELERSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEV--NMQALK 726
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1071-1360 2.00e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 42.63  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1071 ELSKQLKDL--SQKYSDVKSEREKLVEEKAKQ--ASEIL-AAQNLLQKQPVPLEQVEALkksLNGTIEQLKEELRSKQRC 1145
Cdd:pfam07902   89 ELNLELTDTknSNLWSKIKLNNNGMLREYHNDtiKTEIVeSAEGIATRISEDTDKKLAL---INETISGIRREYQDADRQ 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 LERE-QQTVSQLQQLLENQKNssvtlaehlklkeALEKEVGIMKASLrekeeeSQKKTKEVSKLQTEVQTTKQAlknlet 1224
Cdd:pfam07902  166 LSSSyQAGIEGLKATMASDKI-------------GLQAEIQASAQGL------SQRYDNEIRKLSAKITTTSSG------ 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1225 revvdmskykaTKNDLETQISNLNDKLASLNRKYDQACEEKVSA-KDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQR 1303
Cdd:pfam07902  221 -----------TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQSTQQSTAYQISQEISNREGAVSRVQQDLDSYQRR 289

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306 1304 IQESAKQIEAkdnkitellndverLKQALNGL-SQLTYSSGSPTKRQSQLVDTLQQRV 1360
Cdd:pfam07902  290 LQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESRITQLAGLIEQKV 333
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 990-1336 2.01e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.71  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  990 APLARLEECERKfkATEKGLKEQLSEQTHKCRQRDeevKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKA 1069
Cdd:pfam05667  214 AELAAAQEWEEE--WNSQGLASRLTPEEYRKRKRT---KLLKRIAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSS 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1070 DELSKQLK----DLSQKYSDVKSEREKLVEEKAKQASEilaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELrskqrc 1145
Cdd:pfam05667  289 TTDTGLTKgsrfTHTEKLQFTNEAPAATSSPPTKVETE----EELQQQREEELEELQEQLEDLESSIQELEKEI------ 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 lEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEEsqkktkeVSKLQTEVQTTKQALKNL--- 1222
Cdd:pfam05667  359 -KKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDL-------LPDAEEN-------IAKLQALVDASAQRLVELagq 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1223 -ETREVVDMSKY---KATKNDLETQISNLNDKLASLNRKYdQACEEKVSAKDE--KELLhlsieqeirDQKERCDKSlTT 1296
Cdd:pfam05667  424 wEKHRVPLIEEYralKEAKSNKEDESQRKLEEIKELREKI-KEVAEEAKQKEElyKQLV---------AEYERLPKD-VS 492

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1039794306 1297 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1336
Cdd:pfam05667  493 RSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 954-1217 2.39e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 42.37  E-value: 2.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  954 LADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK------FKATEKGLKEQLSEQTHKCRQRDEEV 1027
Cdd:pfam05622   96 VLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKKledlgdLRRQVKLLEERNAEYMQRTLQLEEEL 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1028 KKGKQenerLRADLAALQKELQDrnalaeeAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK-------- 1099
Cdd:pfam05622  176 KKANA----LRGQLETYKRQVQE-------LHGKLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTlretneel 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1100 -----QASEILAAQNLLQKQPVPLEQV--EALKKSLNGTIEQLKEE---LRSKQRCLEREQQTVsqLQQLLENQKNSSVT 1169
Cdd:pfam05622  245 rcaqlQQAELSQADALLSPSSDPGDNLaaEIMPAEIREKLIRLQHEnkmLRLGQEGSYRERLTE--LQQLLEDANRRKNE 322

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794306 1170 LAEHLKLKE----------------------------ALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1217
Cdd:pfam05622  323 LETQNRLANqrilelqqqveelqkalqeqgskaedssLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLA 398
PRK11281 PRK11281
mechanosensitive channel MscK;
1068-1411 2.47e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1068 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNL--LQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRC 1145
Cdd:PRK11281    81 ETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1146 LEREQQTVS----QLQQ---LLENQKNSSVTLAEHLKLKEALEkevgimKASLREKEEESQKKTKEVSKLQtEVQTTKQA 1218
Cdd:PRK11281   158 PERAQAALYansqRLQQirnLLKGGKVGGKALRPSQRVLLQAE------QALLNAQNDLQRKSLEGNTQLQ-DLLQKQRD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1219 LKNLETrevvdmskykatkNDLETQISNLNDklaSLNRKYDQACEEKVSakdekellhlsiEQEIRDQKERCDKSLTTIM 1298
Cdd:PRK11281   231 YLTARI-------------QRLEHQLQLLQE---AINSKRLTLSEKTVQ------------EAQSQDEAARIQANPLVAQ 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1299 ELQQRIQESAKQIEAKDnKITELLNDVERLKQALNGLSQltysSGSPTKRQ-SQLVDTL-------QQR--------VRD 1362
Cdd:PRK11281   283 ELEINLQLSQRLLKATE-KLNTLTQQNLRVKNWLDRLTQ----SERNIKEQiSVLKGSLllsrilyQQQqalpsadlIEG 357

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1363 LQQQLADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGL 1411
Cdd:PRK11281   358 LADRIADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
PHA02946 PHA02946
ankyin-like protein; Provisional
 152-228 2.60e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 2.60e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306  152 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLVKNGADL 228
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKI 133
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1119-1337 2.62e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1119 EQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQllenqKNSSVTLAEHLKLkeaLEKEVGIMKASLREKEEES 1198
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKL---LLQQLSELESQLAEARAEL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1199 QKKTKEVSKLQTEVQTTKQALKNLETREVVdmSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLS 1278
Cdd:COG3206    236 AEAEARLAALRAQLGSGPDALPELLQSPVI--QQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQR 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039794306 1279 IEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQ 1337
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1032-1310 2.75e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 42.45  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1032 QENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQ---KYSDVKSEREKLVEEKA--KQASEILA 1106
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGK-ALNFNKAVAEAKSTGNYDEVKKAQKDLEKslrKREHLEKEVEKKLESKSgnKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1107 AQNLLQKQPVPLEQVEALKKS----LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH-LKLKEALE 1181
Cdd:pfam18971  652 QANSQKDEIFALINKEANRDAraiaYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEEtLKALKGSV 731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1182 KEVGImkaslrekeeesqkKTKEVSKlqteVQTTKQALKNLETREVVDMSKYKATKNDLETQISN------LNDKLASLN 1255
Cdd:pfam18971  732 KDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviinqkVTDKVDNLN 793

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306 1256 RKYDQACEEKVSAKDEK---ELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ 1310
Cdd:pfam18971  794 QAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1093-1321 3.19e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 3.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1093 LVEEKAKQASEILAAQNLLQkqpVPLEQVEALKKSlngtIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1172
Cdd:pfam10174  371 LTEEKSTLAGEIRDLKDMLD---VKERKINVLQKK----IENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEE 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1173 HLKLK----EALEKEVGIMKASLREKEEESQKKTKE----VSKLQTEVQTTKQAL-------KNLETREVVDMSKYKATK 1237
Cdd:pfam10174  444 ALSEKeriiERLKEQREREDRERLEELESLKKENKDlkekVSALQPELTEKESSLidlkehaSSLASSGLKKDSKLKSLE 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1238 NDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1317
Cdd:pfam10174  524 IAVEQKKEECSKLENQLKKAHNAEEAVRTNPEINDRIRLL--EQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKK 601


                   ....
gi 1039794306 1318 ITEL 1321
Cdd:pfam10174  602 IAEL 605
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 168-196 3.39e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*....
gi 1039794306  168 DGRTPLVLATQMCRPTICQLLIDRGADVN 196
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
157-206 3.52e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 3.52e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039794306  157 DHG-ASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1118-1406 3.74e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1118 LEQVEALKKSLnGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGIMKASLREKEEE 1197
Cdd:TIGR02169  176 LEELEEVEENI-ERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1198 SQKKTKEVSKLQTEVQTTKQALKNLETReVVDMSKYKAtkNDLETQISNLNDKLASLNRKYDQAceekvsakdekellhl 1277
Cdd:TIGR02169  253 LEKLTEEISELEKRLEEIEQLLEELNKK-IKDLGEEEQ--LRVKEKIGELEAEIASLERSIAEK---------------- 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1278 siEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQltyssgsPTKRQSQLVDTLQ 1357
Cdd:TIGR02169  314 --ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRA-------ELEEVDKEFAETR 384

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1358 QRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQGHMD-EDVQAALLQIIQ 1406
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEElADLNAAIAGIEA 434
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 19-177 4.02e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   19 PSSPTAVASTQSaEWNKYDDRL--MKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASkGNLECLNAILTHGIDV 96
Cdd:PTZ00322    31 PISFERMAAIQE-EIARIDTHLeaLEATENKDATPDHNLTTEEVIDPVVAHMLTVELCQLAAS-GDAVGARILLTGGADP 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306   97 ATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL-----CDHGASVNAK--DIDG 169
Cdd:PTZ00322   109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqCHFELGANAKpdSFTG 188


                   ....*...
gi 1039794306  170 RTPLVLAT 177
Cdd:PTZ00322   189 KPPSLEDS 196
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
544-736 4.07e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  544 RIIEELREQLKDLKGKYEGASAEVGKLRSQiKQSEMLVGEFKRDEGRLVEENKRLQkecgtcEVELERRgrrvvELEGQL 623
Cdd:COG3206    175 KALEFLEEQLPELRKELEEAEAALEEFRQK-NGLVDLSEEAKLLLQQLSELESQLA------EARAELA-----EAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  624 KELGAKLALS---VPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQhirpeeheqLRSRLEQ 700
Cdd:COG3206    243 AALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQ---------LQQEAQR 313

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039794306  701 KSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQ 736
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1098-1359 4.51e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 4.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1098 AKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNGTIEQLKEELRSK--QRCLEREQQTVSQLQQLLENQKNSSVTLA 1171
Cdd:PRK10929    20 ATAPDEKQITQELEQakaaKTPAQAEIVEALQSALNWLEERKGSLERAKqyQQVIDNFPKLSAELRQQLNNERDEPRSVP 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1172 EHLKLKEaLEKEVGIMKASLREKEEESQK---KTKEVS-------KLQTEvqtTKQALKNLETREvvdMSKYKATKNDLE 1241
Cdd:PRK10929   100 PNMSTDA-LEQEILQVSSQLLEKSRQAQQeqdRAREISdslsqlpQQQTE---ARRQLNEIERRL---QTLGTPNTPLAQ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1242 TQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSL----TTIMELQQRIQESA--------K 1309
Cdd:PRK10929   173 AQLTALQAESAALKALVDELELAQLSANNRQELARLRSEL-AKKRSQQLDAYLqalrNQLNSQRQREAERAlestellaE 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039794306 1310 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSptkRQSQLV-DTLQQR 1359
Cdd:PRK10929   252 QSGDLPKSIVAQFKINRELSQALNQQAQRMDLIAS---QQRQAAsQTLQVR 299
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
946-1152 5.16e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  946 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplaRLEECERkfkatekgLKEQLSEQThKCRQRDE 1025
Cdd:COG4913    608 NRAKLAALEAELAELEEELAEAEERLEALEAELDALQE----------RREALQR--------LAEYSWDEI-DVASAER 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1026 EVKKGKQENERLRA---DLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS 1102
Cdd:COG4913    669 EIAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1103 EILAAQNLLQKQPvplEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT 1152
Cdd:COG4913    749 ALLEERFAAALGD---AVERELRENLEERIDALRARLNRAEEELERAMRA 795
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-222 5.54e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.54e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039794306  169 GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLV 222
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN02939 PLN02939
transferase, transferring glycosyl groups
 542-928 5.63e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.43  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  542 SHRIIEEL----REQLKDLKGKYEGASAEVGKLRSQIKQSE---MLVGEFK----RDEGRLVEENKRLQKECGTCEVELE 610
Cdd:PLN02939   101 SMQRDEAIaaidNEQQTNSKDGEQLSDFQLEDLVGMIQNAEkniLLLNQARlqalEDLEKILTEKEALQGKINILEMRLS 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  611 RRGRRVVeLEGQlkelgAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEE 690
Cdd:PLN02939   181 ETDARIK-LAAQ-----EKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  691 HEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhadnkllnqqvhsltvemktryVPLRVSEEMKKshdvnVEDLNK 770
Cdd:PLN02939   255 TEERVFKLEKERSLLDASLRELESKFIVAQEDVSKL----------------------SPLQYDCWWEK-----VENLQD 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  771 KLSEATQRytekKQEAERLLAENDKLTKNVSRLEAVFVApekhekelmglkSNIAELKKQLSELNkkcgegQEKIRALMS 850
Cdd:PLN02939   308 LLDRATNQ----VEKAALVLDQNQDLRDKVDKLEASLKE------------ANVSKFSSYKVELL------QQKLKLLEE 365

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794306  851 EnsslkktlsSQYVPAKTHEEVKASLNSTVEktnralleakkrFDDTsqeVSKLRDENEvlRRNLENVQNQMKADYVS 928
Cdd:PLN02939   366 R---------LQASDHEIHSYIQLYQESIKE------------FQDT---LSKLKEESK--KRSLEHPADDMPSEFWS 417
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1098-1317 5.68e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 5.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1098 AKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ-QLLENQKNSSVTLAEHLKL 1176
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEqELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1177 KEALEKEVGIMKASLREKEEESQKKTKEV---SKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1253
Cdd:COG4942     96 RAELEAQKEELAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306 1254 LNRKYDQACEEKV---SAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1317
Cdd:COG4942    176 LEALLAELEEERAaleALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 771-983 6.54e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 6.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  771 KLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 850
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNE----------EYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  851 EnssLKKTLSSQYVPAKTHEEVKASLNST--VEKTNRALLEAK--KRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 926
Cdd:COG3883     87 E---LGERARALYRSGGSVSYLDVLLGSEsfSDFLDRLSALSKiaDADADLLEELKADKAELEAKKAELEAKLAELEALK 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794306  927 VSLEEhsrRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQE 983
Cdd:COG3883    164 AELEA---AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAA 217
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 295-620 6.58e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  295 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 374
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  375 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 454
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  455 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 531
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  532 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 611
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1039794306  612 RGRRVVELE 620
Cdd:TIGR02169  936 IEDPKGEDE 944
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1091-1213 8.67e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.58  E-value: 8.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1091 EKLVEEKAKQASEILAAQNLLQkqpvpleQVEALKKSLNGTIEQLKEELRSKQRCLERE-QQTVSQ--------LQQLLE 1161
Cdd:PRK00409   523 ASLEELERELEQKAEEAEALLK-------EAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEakkeadeiIKELRQ 595

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039794306 1162 NQKNSSVTLAEHlKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQ 1213
Cdd:PRK00409   596 LQKGGYASVKAH-ELIEARKR--------LNKANEKKEKKKKKQKEKQEELK 638
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1103-1366 8.98e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 8.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1103 EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvTLAEHLKLKEALEK 1182
Cdd:COG5022    763 RYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQK----TIKREKKLRETEEV 838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1183 EVGIMKASLREKEEESQKKTKEVSKLQTEV--QTTKQALKNLETR------EVVDMSKYKATKNDLETQISNLND----- 1249
Cdd:COG5022    839 EFSLKAEVLIQKFGRSLKAKKRFSLLKKETiyLQSAQRVELAERQlqelkiDVKSISSLKLVNLELESEIIELKKslssd 918

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1250 -------------KLASLNRKYD-------QACEEKVSAKD------------EKELLHLSIEQEIRDQKERCDKS---- 1293
Cdd:COG5022    919 lienlefkteliaRLKKLLNNIDleegpsiEYVKLPELNKLhevesklketseEYEDLLKKSTILVREGNKANSELknfk 998

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039794306 1294 --LTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGsPTKRQSQLVDTLQQRVRDLQQQ 1366
Cdd:COG5022    999 keLAELSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQK-LKGLLLLENNQLQARYKALKLR 1072
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 941-1409 9.03e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.72  E-value: 9.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  941 QSLKEAQEANAAILADhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK--------FKATEKGLKEQ 1012
Cdd:TIGR00618  156 QFLKAKSKEKKELLMN-LFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1013 LSE--QTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1090
Cdd:TIGR00618  235 LQQtqQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQ-EAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIH 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1091 EKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT-----VSQLQQLLENQKN 1165
Cdd:TIGR00618  314 TELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1166 SSVTLAEHLKLKEALEKEVGIMKASLR---------EKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKAT 1236
Cdd:TIGR00618  394 KLQSLCKELDILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1237 K-NDLETQISNLNDK----LASLNRKYDQACEEKVSAKDEKELLHLSIEQEIrdQKERCDKSLTTIMELQQRIQESAKQI 1311
Cdd:TIGR00618  474 QlQTKEQIHLQETRKkavvLARLLELQEEPCPLCGSCIHPNPARQDIDNPGP--LTRRMQRGEQTYAQLETSEEDVYHQL 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1312 EAKDNKITELLNDVERLKQALNGLSQLTYSSgsptkrqSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQG 1391
Cdd:TIGR00618  552 TSERKQRASLKEQMQEIQQSFSILTQCDNRS-------KEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPE 624

                          490
                   ....*....|....*...
gi 1039794306 1392 HMDEDVQAALLQIIQMRQ 1409
Cdd:TIGR00618  625 QDLQDVRLHLQQCSQELA 642
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 755-1328 1.00e-02

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 40.59  E-value: 1.00e-02
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  755 EEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVF--VAPEKHEKELMGLKSNIAELKKQLS 832
Cdd:PTZ00440   962 EKTLEYYDKSKENINGNDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNILNKKIddLIKKQHDDIIELIDKLIKEKGKEIE 1041

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  833 ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTH----EEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDEN 908
Cdd:PTZ00440  1042 EKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEikllEEKVEALLKKIDENKNKLIEIKNKSHEHVVNADKEKNKQ 1121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  909 ----EVLRRNLENVQNQMKADYVSLEEhSRRMSTVSQSLKEAQEANAAILADHrqgqeeivsLHAEIKAQKKELDTIQEC 984
Cdd:PTZ00440  1122 tehyNKKKKSLEKIYKQMEKTLKELEN-MNLEDITLNEVNEIEIEYERILIDH---------IVEQINNEAKKSKTIMEE 1191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306  985 IKLKYAPLARLEEceRKFKATEKGLKE-QLSEQTHKCRQRDEEVKKGKQENERLRadlaalqkelqdrnalaeeareaer 1063
Cdd:PTZ00440  1192 IESYKKDIDQVKK--NMSKERNDHLTTfEYNAYYDKATASYENIEELTTEAKGLK------------------------- 1244

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1064 alsGKADElSKQLKDLSQKYSDVKSEREKLVEEkakqaseilaaQNLLQKQPVPLEQVEALKKSLNGTiEQLKEELRSKQ 1143
Cdd:PTZ00440  1245 ---GEANR-STNVDELKEIKLQVFSYLQQVIKE-----------NNKMENALHEIKNMYEFLISIDSE-KILKEILNSTK 1308

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1144 RCLEREQQTVSQLQQllenqknsSVTLAEHLKLKEALEKEvGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLe 1223
Cdd:PTZ00440  1309 KAEEFSNDAKKELEK--------TDNLIKQVEAKIEQAKE-HKNKIYGSLEDKQIDDEIKKIEQIKEEISNKRKEINKY- 1378

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794306 1224 trevvdMSKYKATKNDLETQISNLN---DKLASLNRKydqaceEKVSAKDEKELLHlsieQEIRDQKERCDKSLTTIMEL 1300
Cdd:PTZ00440  1379 ------LSNIKSNKEKCDLHVRNASrgkDKIDFLNKH------EAIEPSNSKEVNI----IKITDNINKCKQYSNEAMET 1442

                          570       580
                   ....*....|....*....|....*...
gi 1039794306 1301 QQRIQESAKQIEAKDNKITELLNDVERL 1328
Cdd:PTZ00440  1443 ENKADENNDSIIKYEKEITNILNNSSIL 1470
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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