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Conserved domains on  [gi|1830925708|ref|XP_017153132|]
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laminin subunit alpha-1 isoform X2 [Drosophila miranda]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
174-419 4.25e-75

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 250.19  E-value: 4.25e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  174 YPPLFNVAPRASITVNATCGQNGAEEYCKLVdaypHRNWAKQCGTCNghSSDRAKQRPIESLISPGSGFEEIWWQSPTLQ 253
Cdd:pfam00055    2 YPAFGNLAFGREVSATSTCGLNGPERYCILS----GLEGGKKCFICD--SRDPHNSHPPSNLTDSNNGTNETWWQSETGV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  254 ggRHFEYVTITLDLKQTYQVFFVMLKSAnSPRPASWILEKSLD-GVDYEPWQYFglsDADCRRRWSLsgQNGKYVFQNDT 332
Cdd:pfam00055   76 --IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGIKDD 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  333 EVICSTQFSKPLPLENGELHVSLLKNRPGA--MDQSPELMQFITARYMRIRLQGMHSTAnldnsvDWLLDSPSLEKRSFY 410
Cdd:pfam00055  148 EVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRKYYY 221


                   ....*....
gi 1830925708  411 SLKQLRVSA 419
Cdd:pfam00055  222 AISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
1504-1644 7.63e-29

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.90  E-value: 7.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1504 YFQLPPQFYGDRTSSYGGYLYFSLITEgahTPLERQILAQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESLW 1582
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE---PLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 1583 KyHHNNQAVDRGTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAifIEGSTNLIAKGVE 1644
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSA--VPGGSGPPASWVE 136
Laminin_B pfam00052
Laminin B (Domain IV);
680-812 9.88e-23

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 96.18  E-value: 9.88e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  680 YWQAPLGYLGNRLTSYGARLQLLLSWVVMRGdtSGKSSTGPNVILCGtNGLKIGYADDSFVGLEASLN----VTLTEEGW 755
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPG--GGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708  756 YHVPPAikdiktrlrrteggeyhgeAVTRSQFLSVLVSLDAMLIRAAFHTDQVETSL 812
Cdd:pfam00052   78 RDSDGA-------------------PVSREDFMMVLANLTAILIRATYSTGSGQVSL 115
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2822-2962 5.24e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 5.24e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2822 FRTLQPDCLLLLAAyppevladyddkDIKGNY-SMSLVDGQLHVWVNSGRSFVKLSSNISQLNDGELHVINMIKTGRRLE 2900
Cdd:pfam02210    1 FRTRQPNGLLLYAG------------GGGSDFlALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLT 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 2901 LMVDDELQDVRSLSGNPTVISLPreaGGLYIGGAPPhESFTPLAPTFVNLEGAIRDVVFNNR 2962
Cdd:pfam02210   69 LSVDGQTVVSSLPPGESLLLNLN---GPLYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2604-2771 1.64e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 1.64e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2604 ARHFNGLGYAQLmkTRPRPYRKNlFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2683
Cdd:cd00110      1 GVSFSGSSYVRL--PTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2684 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNAHLLPDLskavYYLGGVPPGFTSGTTKAPgadNPFLG 2763
Cdd:cd00110     77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                   ....*...
gi 1830925708 2764 CMTDVQVN 2771
Cdd:cd00110    144 CIRDLKVN 151
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1217-1265 2.94e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.92  E-value: 2.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1265
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1312-1360 1.96e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.91  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYPECRRCGC 1360
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1168-1215 6.88e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 6.88e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWNL-TQGVGCH 1215
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1085-1132 1.33e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.33e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1830925708 1085 CSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGLNVDAQQ 1132
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1687-1734 1.35e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.60  E-value: 1.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1687 PCHCNGRSS---DCDKESGVCQnCRANSGGDHCQQCAEGFYGDPNSPHGCQ 1734
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 871-920 6.48e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 6.48e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1830925708  871 PCPCNGH---SNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPLQgtPHDCK 920
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 571-618 1.45e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.82  E-value: 1.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  571 CECDERGTLSSDgsC---SGKCQCKLNVEGETCSECAPGYFDLSDRNPLGC 618
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1791-1836 1.46e-09

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 1.46e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708  1791 CNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCLAERHHVVDNGC 1836
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1037-1085 4.00e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1037 PCLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGFAHVDLRCPPC 1085
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
527-571 5.11e-09

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 5.11e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708   527 CSCDPIRS-TGSCHPEGGRCNCLVGFQGNQCQECAPGYYGEECKPC 571
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2097-2408 3.04e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 3.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2097 DQGEELARLTLERQSLLSEhLNQLDGATVLLNATLGVKSEQQREVRKHwLPKAEKHADRLLERSNEyaRQFQPTRNGARI 2176
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKE-LEELEEELEQLRKELEELSRQISALRKD-LARLEAEVEQLEERIAQ--LSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2177 AILASSAHSNITKAInDARQGSILAKERVYDAQRTLypSDGSSMIE--RAKHSLHRSRQLQQEALKQMHKSNV------- 2247
Cdd:TIGR02168  764 EELEERLEEAEEELA-EAEAEIEELEAQIEQLKEEL--KALREALDelRAELTLLNEEAANLRERLESLERRIaaterrl 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2248 --LKEKLHQQQEQVEGIKATIFESGLRTNNISSQLQTLTDssARRHAKESLDLARRTGEQMRAELR----KAKETEESLQ 2321
Cdd:TIGR02168  841 edLEEQIEELSEDIESLAAEIEELEELIEELESELEALLN--ERASLEEALALLRSELEELSEELRelesKRSELRRELE 918

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2322 NMRKSftklepdwdiklgMAQENISLTKTNLRLANVsLSYLEQQAAKEQQVFESWNNSMAKQLQQLRDQIAKARHAAQAI 2401
Cdd:TIGR02168  919 ELREK-------------LAQLELRLEGLEVRIDNL-QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984


                   ....*...
gi 1830925708 2402 -DVSLESL 2408
Cdd:TIGR02168  985 gPVNLAAI 992
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 994-1038 1.13e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.13e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708  994 CDC-----AGGPCNVTTGACItCKGNTEGWHCERCKLGYWGDPAVGCEPC 1038
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1736-1786 4.94e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 4.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1736 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNPTLYPNS 1786
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1358-1410 3.29e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 3.29e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1830925708 1358 CGCNADGSFTRAdgliaCDSN-GQCPCKSLVVGLKCDTCMQSTFGLSALNPEGC 1410
Cdd:pfam00053    1 CDCNPHGSLSDT-----CDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1265-1310 2.93e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 2.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708 1265 CSACTAEGQICDSHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1310
Cdd:cd00055      4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 422-471 3.86e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.42  E-value: 3.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  422 DCHGHSDRTQE-APGSpvVQCVCQHNACGVQCEECCPLFQDRPYRLsEECE 471
Cdd:cd00055      3 DCNGHGSLSGQcDPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQG-GGCQ 50
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2449-2524 9.47e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 9.47e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708 2449 GSEGRHITLELYKRRVRLVWNLGGTTATVTHPmvvqtrdPKYDD-AWYHVEANRTLNLGSLLVrrmNNYGVLTPSSP 2524
Cdd:cd00110     43 QNGGDFLALELEDGRLVLRYDLGSGSLVLSSK-------TPLNDgQWHSVSVERNGRSVTLSV---DGERVVESGSP 109
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 963-991 3.22e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.72  E-value: 3.22e-03
                           10        20
                   ....*....|....*....|....*....
gi 1830925708  963 QCPEGFTGDHCQVCDDGYFGDPLQIGSSC 991
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
174-419 4.25e-75

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 250.19  E-value: 4.25e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  174 YPPLFNVAPRASITVNATCGQNGAEEYCKLVdaypHRNWAKQCGTCNghSSDRAKQRPIESLISPGSGFEEIWWQSPTLQ 253
Cdd:pfam00055    2 YPAFGNLAFGREVSATSTCGLNGPERYCILS----GLEGGKKCFICD--SRDPHNSHPPSNLTDSNNGTNETWWQSETGV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  254 ggRHFEYVTITLDLKQTYQVFFVMLKSAnSPRPASWILEKSLD-GVDYEPWQYFglsDADCRRRWSLsgQNGKYVFQNDT 332
Cdd:pfam00055   76 --IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGIKDD 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  333 EVICSTQFSKPLPLENGELHVSLLKNRPGA--MDQSPELMQFITARYMRIRLQGMHSTAnldnsvDWLLDSPSLEKRSFY 410
Cdd:pfam00055  148 EVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRKYYY 221


                   ....*....
gi 1830925708  411 SLKQLRVSA 419
Cdd:pfam00055  222 AISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 174-417 5.04e-63

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 215.69  E-value: 5.04e-63
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   174 YPPLFNVAPRASITVNATCGQNGAEEYCKLVdayPHRNWAKQCGTCNghSSDRAKQRPIESLISPGSGFEEIWWQSPTLQ 253
Cdd:smart00136    8 YPPFVNLAFGREVTATSTCGEPGPERYCKLV---GHTEQGKKCDYCD--ARNPRRSHPAENLTDGNNPNNPTWWQSEPLS 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   254 GGRHfeYVTITLDLKQTYQVFFVMLKSAnSPRPASWILEKSLDGVDYEPWQYFGlsdADCRRRWSL--SGQNGKYvfqND 331
Cdd:smart00136   83 NGPQ--NVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRppRGPITKG---NE 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   332 TEVICSTQFSKPLPLENGELHVSLLKNRPGA--MDQSPELMQFITARYMRIRLQGMHS-TANLDNsvdwllDSPSLEKRS 408
Cdd:smart00136  154 DEVICTSEYSDIVPLEGGEIAFSLLEGRPSAtdFDNSPVLQEWVTATNIRVRLTRLRTlGDELMD------DRPEVTRRY 227


                    ....*....
gi 1830925708   409 FYSLKQLRV 417
Cdd:smart00136  228 YYAISDIAV 236
Laminin_B pfam00052
Laminin B (Domain IV);
1504-1644 7.63e-29

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.90  E-value: 7.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1504 YFQLPPQFYGDRTSSYGGYLYFSLITEgahTPLERQILAQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESLW 1582
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE---PLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 1583 KyHHNNQAVDRGTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAifIEGSTNLIAKGVE 1644
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSA--VPGGSGPPASWVE 136
Laminin_B pfam00052
Laminin B (Domain IV);
680-812 9.88e-23

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 96.18  E-value: 9.88e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  680 YWQAPLGYLGNRLTSYGARLQLLLSWVVMRGdtSGKSSTGPNVILCGtNGLKIGYADDSFVGLEASLN----VTLTEEGW 755
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPG--GGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708  756 YHVPPAikdiktrlrrteggeyhgeAVTRSQFLSVLVSLDAMLIRAAFHTDQVETSL 812
Cdd:pfam00052   78 RDSDGA-------------------PVSREDFMMVLANLTAILIRATYSTGSGQVSL 115
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2822-2962 5.24e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 5.24e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2822 FRTLQPDCLLLLAAyppevladyddkDIKGNY-SMSLVDGQLHVWVNSGRSFVKLSSNISQLNDGELHVINMIKTGRRLE 2900
Cdd:pfam02210    1 FRTRQPNGLLLYAG------------GGGSDFlALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLT 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 2901 LMVDDELQDVRSLSGNPTVISLPreaGGLYIGGAPPhESFTPLAPTFVNLEGAIRDVVFNNR 2962
Cdd:pfam02210   69 LSVDGQTVVSSLPPGESLLLNLN---GPLYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2604-2771 1.64e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 1.64e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2604 ARHFNGLGYAQLmkTRPRPYRKNlFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2683
Cdd:cd00110      1 GVSFSGSSYVRL--PTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2684 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNAHLLPDLskavYYLGGVPPGFTSGTTKAPgadNPFLG 2763
Cdd:cd00110     77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                   ....*...
gi 1830925708 2764 CMTDVQVN 2771
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2634-2773 3.11e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 3.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2634 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 2713
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2714 DRPISGAPTLPVnahlLPDLSKAVYYLGGVPPGFTSGTTKAPgadNPFLGCMTDVQVNGE 2773
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2797-2960 1.84e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 87.47  E-value: 1.84e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2797 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAayppevladyDDKDIKGNYSMSLVDGQLHVWVNSGRSFVKL 2875
Cdd:cd00110      2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYA----------GSQNGGDFLALELEDGRLVLRYDLGSGSLVL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2876 SSnISQLNDGELHVINMIKTGRRLELMVDDELQdVRSLSGNPTVISLPReaGGLYIGGAPPHESFTPLAPTfVNLEGAIR 2955
Cdd:cd00110     72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERV-VESGSPGGSALLNLD--GPLYLGGLPEDLKSPGLPVS-PGFVGCIR 146


                   ....*
gi 1830925708 2956 DVVFN 2960
Cdd:cd00110    147 DLKVN 151
LamB smart00281
Laminin B domain;
1500-1629 3.66e-19

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 85.78  E-value: 3.66e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  1500 YHPLYFQLPPQFYGDRTSSYGGYLYFSL---ITEGAHTPLErqilaqyPLVQLH-AHSKLlldfyEYEEFEYSLN---VT 1572
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLsfdGRRGGTHVSA-------PDVILEgNGLRI-----SHPAEGPPLPdelTT 69

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708  1573 HRVPLHESLWKYHHnNQAVDRGTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 1629
Cdd:smart00281   70 VEVRFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
LamG smart00282
Laminin G domain;
2629-2773 4.08e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.85  E-value: 4.08e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2629 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 2708
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830925708  2709 LRVNNDRPISG-APTLPVNAHLlpdlsKAVYYLGGVPPGFTSGTTKAPgadNPFLGCMTDVQVNGE 2773
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2820-2962 4.35e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.77  E-value: 4.35e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2820 LVFRTLQPDCLLLLAAyppevlaDYDDKDIkgnYSMSLVDGQLHVWVNSGRSFVKLSSNISQLNDGELHVINMIKTGRRL 2899
Cdd:smart00282    4 FSFRTTSPNGLLLYAG-------SKGGGDY---LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1830925708  2900 ELMVDDELQDVRSLSGNPTVISLPreaGGLYIGGAPPHESFTPLaPTFVNLEGAIRDVVFNNR 2962
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamB smart00281
Laminin B domain;
676-812 1.84e-14

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 72.29  E-value: 1.84e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   676 LEAIYWQAPLGYLGNRLTSYGARLQLLLSWVVMRGDTSGKSstgPNVILCGtNGLKIGYaddsfvgleaslnvtlteegW 755
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHVSA---PDVILEG-NGLRISH--------------------P 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   756 YHVPPAIKD---IKTRLRRTEGGEYHGEAVTRSQFLSVLVSLDAMLIRAAFHTDQVETSL 812
Cdd:smart00281   58 AEGPPLPDElttVEVRFREENWQYYGGRPVTREDLMMVLANLTAILIRATYSQQMAGSRL 117
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1217-1265 2.94e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.92  E-value: 2.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1265
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1217-1263 7.79e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.07  E-value: 7.79e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 1263
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1217-1262 8.75e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 64.64  E-value: 8.75e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708  1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 1262
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1312-1360 1.96e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.91  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYPECRRCGC 1360
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1312-1354 2.42e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 63.53  E-value: 2.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYPE 1354
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1168-1215 6.88e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 6.88e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWNL-TQGVGCH 1215
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1085-1132 1.33e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.33e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1830925708 1085 CSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGLNVDAQQ 1132
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1687-1734 1.35e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.60  E-value: 1.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1687 PCHCNGRSS---DCDKESGVCQnCRANSGGDHCQQCAEGFYGDPNSPHGCQ 1734
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1168-1214 3.14e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.44  E-value: 3.14e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWNL--TQGVGC 1214
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1312-1353 3.41e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.40  E-value: 3.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1830925708  1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYP 1353
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1084-1126 6.70e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 6.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 1084 PCSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGL 1126
Cdd:cd00055      1 PCDCNGHGS-LSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1168-1217 1.19e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.86  E-value: 1.19e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1830925708  1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWnltqGVGCHDC 1217
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY----GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1085-1127 1.87e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.09  E-value: 1.87e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1830925708  1085 CSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGLN 1127
Cdd:smart00180    1 CDCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 871-920 6.48e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 6.48e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1830925708  871 PCPCNGH---SNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPLQgtPHDCK 920
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1688-1733 7.69e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 7.69e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1688 CHCNGRSS---DCDKESGVCQnCRANSGGDHCQQCAEGFYGDP-NSPHGC 1733
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 571-618 1.45e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.82  E-value: 1.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  571 CECDERGTLSSDgsC---SGKCQCKLNVEGETCSECAPGYFDLSDRNPLGC 618
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1791-1836 1.46e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 1.46e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708  1791 CNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCLAERHHVVDNGC 1836
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1037-1085 4.00e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1037 PCLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGFAHVDLRCPPC 1085
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
527-571 5.11e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 5.11e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708   527 CSCDPIRS-TGSCHPEGGRCNCLVGFQGNQCQECAPGYYGEECKPC 571
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1790-1825 8.17e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 8.17e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1830925708 1790 ACNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCL 1825
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCA 36
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 872-919 8.54e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 8.54e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  872 CPCNGH---SNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPlQGTPHDC 919
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1791-1825 1.26e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.26e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1830925708 1791 CNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCL 1825
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1038-1087 2.46e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 2.46e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1038 CLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGFaHVDLRCPPCSC 1087
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY-YGLPSDPPQGC 49
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2097-2408 3.04e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 3.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2097 DQGEELARLTLERQSLLSEhLNQLDGATVLLNATLGVKSEQQREVRKHwLPKAEKHADRLLERSNEyaRQFQPTRNGARI 2176
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKE-LEELEEELEQLRKELEELSRQISALRKD-LARLEAEVEQLEERIAQ--LSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2177 AILASSAHSNITKAInDARQGSILAKERVYDAQRTLypSDGSSMIE--RAKHSLHRSRQLQQEALKQMHKSNV------- 2247
Cdd:TIGR02168  764 EELEERLEEAEEELA-EAEAEIEELEAQIEQLKEEL--KALREALDelRAELTLLNEEAANLRERLESLERRIaaterrl 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2248 --LKEKLHQQQEQVEGIKATIFESGLRTNNISSQLQTLTDssARRHAKESLDLARRTGEQMRAELR----KAKETEESLQ 2321
Cdd:TIGR02168  841 edLEEQIEELSEDIESLAAEIEELEELIEELESELEALLN--ERASLEEALALLRSELEELSEELRelesKRSELRRELE 918

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2322 NMRKSftklepdwdiklgMAQENISLTKTNLRLANVsLSYLEQQAAKEQQVFESWNNSMAKQLQQLRDQIAKARHAAQAI 2401
Cdd:TIGR02168  919 ELREK-------------LAQLELRLEGLEVRIDNL-QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984


                   ....*...
gi 1830925708 2402 -DVSLESL 2408
Cdd:TIGR02168  985 gPVNLAAI 992
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1688-1733 5.85e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 5.85e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1830925708  1688 CHCNGR---SSDCDKESGVCQnCRANSGGDHCQQCAEGFYGDpnSPHGC 1733
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 526-573 9.55e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 9.55e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708  526 ACSCDPIRS-TGSCHPEGGRCNCLVGFQGNQCQECAPGYYGEECKPCEC 573
Cdd:cd00055      1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 570-618 9.74e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 9.74e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1830925708  570 PCECDERGTLSsdGSC---SGKCQCKLNVEGETCSECAPGYFDLSDRnPLGC 618
Cdd:cd00055      1 PCDCNGHGSLS--GQCdpgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 994-1038 1.13e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.13e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708  994 CDC-----AGGPCNVTTGACItCKGNTEGWHCERCKLGYWGDPAVGCEPC 1038
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 527-573 2.36e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.66  E-value: 2.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708  527 CSCDPIRSTGS-CHPEGGRCNCLVGFQGNQCQECAPGYYG-EECKPCEC 573
Cdd:pfam00053    1 CDCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 993-1034 2.70e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.27  E-value: 2.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708  993 RCDC-----AGGPCNVTTGACItCKGNTEGWHCERCKLGYWGDPAVG 1034
Cdd:cd00055      1 PCDCnghgsLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
994-1035 3.03e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 3.03e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1830925708   994 CDC-----AGGPCNVTTGACiTCKGNTEGWHCERCKLGYWGDPAVGC 1035
Cdd:smart00180    1 CDCdpggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
571-618 3.55e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.55e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708   571 CECDERGtlSSDGSC---SGKCQCKLNVEGETCSECAPGYFdlsDRNPLGC 618
Cdd:smart00180    1 CDCDPGG--SASGTCdpdTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
872-914 3.62e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.62e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708   872 CPCNG---HSNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPLQG 914
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1038-1075 3.73e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1830925708  1038 CLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGF 1075
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1736-1786 4.94e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 4.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1736 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNPTLYPNS 1786
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2304-2418 7.82e-06

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 47.87  E-value: 7.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2304 EQMRAELRKAKETEESLQNMRKSFtklePDWDIKLGMAQENISLTK-------TNLRLANVSLSYLEQQA------AKEQ 2370
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNL----ENTSEKLSGINRSLEETNelvndanKALDDAGRSVKKLEELApdlldkLKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1830925708 2371 QVFESWNNSMAKQLQQLRDQIAKARHAAQAIDVSLeSLGPKCIRSYLP 2418
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1735-1781 8.20e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.04  E-value: 8.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708 1735 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNPT 1781
Cdd:cd00055      1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1736-1780 1.83e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.22  E-value: 1.83e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1830925708  1736 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNP 1780
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2126-2394 2.02e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2126 LLNATLGVKSEQQ-RE-VRKHWL--PKAEKHADRLLE---RSNEYARQFQPTRngARIAILA--SSAHSNITKAINDARQ 2196
Cdd:COG4913    196 LLHKTQSFKPIGDlDDfVREYMLeePDTFEAADALVEhfdDLERAHEALEDAR--EQIELLEpiRELAERYAAARERLAE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2197 GSILAKE-RVYDAQRTLypsdgssmiERAKHSLHRSRQLQQEALKQMhksNVLKEKLHQQQEQVEGIKATIFESGLRtnn 2275
Cdd:COG4913    274 LEYLRAAlRLWFAQRRL---------ELLEAELEELRAELARLEAEL---ERLEARLDALREELDELEAQIRGNGGD--- 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2276 issQLQTLTdsSARRHAKESLDLARRTGEQMRAELRKAK----ETEESLQNMRKSFTKLEPDWDIKLGMAQENISLTKTN 2351
Cdd:COG4913    339 ---RLEQLE--REIERLERELEERERRRARLEALLAALGlplpASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 2352 LRLANVSLsyleQQAAKEQQVFESWNNSMAKQLQQLRDQIAKA 2394
Cdd:COG4913    414 LRDLRREL----RELEAEIASLERRKSNIPARLLALRDALAEA 452
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1358-1410 3.29e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 3.29e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1830925708 1358 CGCNADGSFTRAdgliaCDSN-GQCPCKSLVVGLKCDTCMQSTFGLSALNPEGC 1410
Cdd:pfam00053    1 CDCNPHGSLSDT-----CDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1265-1310 2.93e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 2.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708 1265 CSACTAEGQICDSHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1310
Cdd:cd00055      4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1358-1410 3.04e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.76  E-value: 3.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1830925708  1358 CGCNADGSFTRAdgliaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaLNPEGC 1410
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 422-471 3.86e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.42  E-value: 3.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  422 DCHGHSDRTQE-APGSpvVQCVCQHNACGVQCEECCPLFQDRPYRLsEECE 471
Cdd:cd00055      3 DCNGHGSLSGQcDPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQG-GGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1357-1411 4.13e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.42  E-value: 4.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1830925708 1357 RCGCNADGSFTRAdgliaCDS-NGQCPCKSLVVGLKCDTCMQSTFGLsALNPEGCT 1411
Cdd:cd00055      1 PCDCNGHGSLSGQ-----CDPgTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2449-2524 9.47e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 9.47e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708 2449 GSEGRHITLELYKRRVRLVWNLGGTTATVTHPmvvqtrdPKYDD-AWYHVEANRTLNLGSLLVrrmNNYGVLTPSSP 2524
Cdd:cd00110     43 QNGGDFLALELEDGRLVLRYDLGSGSLVLSSK-------TPLNDgQWHSVSVERNGRSVTLSV---DGERVVESGSP 109
Laminin_G_1 pfam00054
Laminin G domain;
2455-2577 1.09e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2455 ITLELYKRRVRLVWNLGGTTATVTHPmvvqtrdPKYDDA-WYHVEANRTLNLGSLLVrrmNNYGVLTPSSPVTITGSTDT 2533
Cdd:pfam00054   22 LALELRDGRLEVSYDLGSGAAVVRSG-------DKLNDGkWHSVELERNGRSGTLSV---DGEARPTGESPLGATTDLDV 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 2534 EhTRFYqsrndrisLGGFAS-----KDLQLTPGLNVVVHHVEVDNKPLG 2577
Cdd:pfam00054   92 D-GPLY--------VGGLPSlgvkkRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
2452-2510 1.41e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 41.17  E-value: 1.41e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2452 GRHITLELYKRRVRLVWNLGGTTATVTHPmvvqtrDPKYDD-AWYHVEANRTLNLGSLLV 2510
Cdd:smart00282   24 GDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 963-991 3.22e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.72  E-value: 3.22e-03
                           10        20
                   ....*....|....*....|....*....
gi 1830925708  963 QCPEGFTGDHCQVCDDGYFGDPLQIGSSC 991
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1270-1302 6.35e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 6.35e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1830925708 1270 AEGQICDSHNGRCICPKFTRGLGCGQCVPGTWG 1302
Cdd:pfam00053    8 SLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
174-419 4.25e-75

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 250.19  E-value: 4.25e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  174 YPPLFNVAPRASITVNATCGQNGAEEYCKLVdaypHRNWAKQCGTCNghSSDRAKQRPIESLISPGSGFEEIWWQSPTLQ 253
Cdd:pfam00055    2 YPAFGNLAFGREVSATSTCGLNGPERYCILS----GLEGGKKCFICD--SRDPHNSHPPSNLTDSNNGTNETWWQSETGV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  254 ggRHFEYVTITLDLKQTYQVFFVMLKSAnSPRPASWILEKSLD-GVDYEPWQYFglsDADCRRRWSLsgQNGKYVFQNDT 332
Cdd:pfam00055   76 --IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGIKDD 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  333 EVICSTQFSKPLPLENGELHVSLLKNRPGA--MDQSPELMQFITARYMRIRLQGMHSTAnldnsvDWLLDSPSLEKRSFY 410
Cdd:pfam00055  148 EVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRKYYY 221


                   ....*....
gi 1830925708  411 SLKQLRVSA 419
Cdd:pfam00055  222 AISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 174-417 5.04e-63

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 215.69  E-value: 5.04e-63
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   174 YPPLFNVAPRASITVNATCGQNGAEEYCKLVdayPHRNWAKQCGTCNghSSDRAKQRPIESLISPGSGFEEIWWQSPTLQ 253
Cdd:smart00136    8 YPPFVNLAFGREVTATSTCGEPGPERYCKLV---GHTEQGKKCDYCD--ARNPRRSHPAENLTDGNNPNNPTWWQSEPLS 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   254 GGRHfeYVTITLDLKQTYQVFFVMLKSAnSPRPASWILEKSLDGVDYEPWQYFGlsdADCRRRWSL--SGQNGKYvfqND 331
Cdd:smart00136   83 NGPQ--NVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRppRGPITKG---NE 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   332 TEVICSTQFSKPLPLENGELHVSLLKNRPGA--MDQSPELMQFITARYMRIRLQGMHS-TANLDNsvdwllDSPSLEKRS 408
Cdd:smart00136  154 DEVICTSEYSDIVPLEGGEIAFSLLEGRPSAtdFDNSPVLQEWVTATNIRVRLTRLRTlGDELMD------DRPEVTRRY 227


                    ....*....
gi 1830925708   409 FYSLKQLRV 417
Cdd:smart00136  228 YYAISDIAV 236
Laminin_B pfam00052
Laminin B (Domain IV);
1504-1644 7.63e-29

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.90  E-value: 7.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1504 YFQLPPQFYGDRTSSYGGYLYFSLITEgahTPLERQILAQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESLW 1582
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE---PLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 1583 KyHHNNQAVDRGTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAifIEGSTNLIAKGVE 1644
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSA--VPGGSGPPASWVE 136
Laminin_B pfam00052
Laminin B (Domain IV);
680-812 9.88e-23

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 96.18  E-value: 9.88e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  680 YWQAPLGYLGNRLTSYGARLQLLLSWVVMRGdtSGKSSTGPNVILCGtNGLKIGYADDSFVGLEASLN----VTLTEEGW 755
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPG--GGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708  756 YHVPPAikdiktrlrrteggeyhgeAVTRSQFLSVLVSLDAMLIRAAFHTDQVETSL 812
Cdd:pfam00052   78 RDSDGA-------------------PVSREDFMMVLANLTAILIRATYSTGSGQVSL 115
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2822-2962 5.24e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 5.24e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2822 FRTLQPDCLLLLAAyppevladyddkDIKGNY-SMSLVDGQLHVWVNSGRSFVKLSSNISQLNDGELHVINMIKTGRRLE 2900
Cdd:pfam02210    1 FRTRQPNGLLLYAG------------GGGSDFlALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLT 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 2901 LMVDDELQDVRSLSGNPTVISLPreaGGLYIGGAPPhESFTPLAPTFVNLEGAIRDVVFNNR 2962
Cdd:pfam02210   69 LSVDGQTVVSSLPPGESLLLNLN---GPLYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2604-2771 1.64e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 1.64e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2604 ARHFNGLGYAQLmkTRPRPYRKNlFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2683
Cdd:cd00110      1 GVSFSGSSYVRL--PTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2684 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNAHLLPDLskavYYLGGVPPGFTSGTTKAPgadNPFLG 2763
Cdd:cd00110     77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                   ....*...
gi 1830925708 2764 CMTDVQVN 2771
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2634-2773 3.11e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 3.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2634 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 2713
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2714 DRPISGAPTLPVnahlLPDLSKAVYYLGGVPPGFTSGTTKAPgadNPFLGCMTDVQVNGE 2773
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2797-2960 1.84e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 87.47  E-value: 1.84e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2797 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAayppevladyDDKDIKGNYSMSLVDGQLHVWVNSGRSFVKL 2875
Cdd:cd00110      2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYA----------GSQNGGDFLALELEDGRLVLRYDLGSGSLVL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2876 SSnISQLNDGELHVINMIKTGRRLELMVDDELQdVRSLSGNPTVISLPReaGGLYIGGAPPHESFTPLAPTfVNLEGAIR 2955
Cdd:cd00110     72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERV-VESGSPGGSALLNLD--GPLYLGGLPEDLKSPGLPVS-PGFVGCIR 146


                   ....*
gi 1830925708 2956 DVVFN 2960
Cdd:cd00110    147 DLKVN 151
LamB smart00281
Laminin B domain;
1500-1629 3.66e-19

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 85.78  E-value: 3.66e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  1500 YHPLYFQLPPQFYGDRTSSYGGYLYFSL---ITEGAHTPLErqilaqyPLVQLH-AHSKLlldfyEYEEFEYSLN---VT 1572
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLsfdGRRGGTHVSA-------PDVILEgNGLRI-----SHPAEGPPLPdelTT 69

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708  1573 HRVPLHESLWKYHHnNQAVDRGTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 1629
Cdd:smart00281   70 VEVRFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
LamG smart00282
Laminin G domain;
2629-2773 4.08e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.85  E-value: 4.08e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2629 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 2708
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830925708  2709 LRVNNDRPISG-APTLPVNAHLlpdlsKAVYYLGGVPPGFTSGTTKAPgadNPFLGCMTDVQVNGE 2773
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2820-2962 4.35e-18

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 82.77  E-value: 4.35e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2820 LVFRTLQPDCLLLLAAyppevlaDYDDKDIkgnYSMSLVDGQLHVWVNSGRSFVKLSSNISQLNDGELHVINMIKTGRRL 2899
Cdd:smart00282    4 FSFRTTSPNGLLLYAG-------SKGGGDY---LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1830925708  2900 ELMVDDELQDVRSLSGNPTVISLPreaGGLYIGGAPPHESFTPLaPTFVNLEGAIRDVVFNNR 2962
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamB smart00281
Laminin B domain;
676-812 1.84e-14

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 72.29  E-value: 1.84e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   676 LEAIYWQAPLGYLGNRLTSYGARLQLLLSWVVMRGDTSGKSstgPNVILCGtNGLKIGYaddsfvgleaslnvtlteegW 755
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHVSA---PDVILEG-NGLRISH--------------------P 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708   756 YHVPPAIKD---IKTRLRRTEGGEYHGEAVTRSQFLSVLVSLDAMLIRAAFHTDQVETSL 812
Cdd:smart00281   58 AEGPPLPDElttVEVRFREENWQYYGGRPVTREDLMMVLANLTAILIRATYSQQMAGSRL 117
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1217-1265 2.94e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.92  E-value: 2.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1265
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1217-1263 7.79e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.07  E-value: 7.79e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 1263
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1217-1262 8.75e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 64.64  E-value: 8.75e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708  1217 CLCDPHGSRGDECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 1262
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_G_1 pfam00054
Laminin G domain;
2634-2776 1.94e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 1.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2634 FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGD-ESKLEINTtkKYNVGQWIKIEaarefsAKRSTENGMLRVN 2712
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSgAAVVRSGD--KLNDGKWHSVE------LERNGRSGTLSVD 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1830925708 2713 NDRPISGAPTLPVNAHLlpDLSKAvYYLGGVPpgftSGTTKAPGADN--PFLGCMTDVQVNGETYD 2776
Cdd:pfam00054   73 GEARPTGESPLGATTDL--DVDGP-LYVGGLP----SLGVKKRRLAIspSFDGCIRDVIVNGKPLD 131
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1312-1360 1.96e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.91  E-value: 1.96e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYPECRRCGC 1360
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_G_1 pfam00054
Laminin G domain;
2822-2965 2.31e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 2.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2822 FRTLQPDCLLLLAAYPPEvlADYddkdikgnYSMSLVDGQLHVWVNSGRSFVKLSSNiSQLNDGELHVINMIKTGRRLEL 2901
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE--RDF--------LALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1830925708 2902 MVDDEL-QDVRSLSGNPTVISLPreaGGLYIGGAPPHESFTPLAPTFVNLEGAIRDVVFNNRTVN 2965
Cdd:pfam00054   70 SVDGEArPTGESPLGATTDLDVD---GPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1312-1354 2.42e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 63.53  E-value: 2.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYPE 1354
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1168-1215 6.88e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 6.88e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWNL-TQGVGCH 1215
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1085-1132 1.33e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.33e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1830925708 1085 CSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGLNVDAQQ 1132
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1687-1734 1.35e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.60  E-value: 1.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1687 PCHCNGRSS---DCDKESGVCQnCRANSGGDHCQQCAEGFYGDPNSPHGCQ 1734
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1168-1214 3.14e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.44  E-value: 3.14e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWNL--TQGVGC 1214
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1312-1353 3.41e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.40  E-value: 3.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1830925708  1312 CECDHIGSIGQQCAPGDGQCQCREGYAGRSCESCAAGYFGYP 1353
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1084-1126 6.70e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 6.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 1084 PCSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGL 1126
Cdd:cd00055      1 PCDCNGHGS-LSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1168-1217 1.19e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.86  E-value: 1.19e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1830925708  1168 CHCSSVGSLSTACDKRSGQCACMANVTGRRCDKCRAGHWnltqGVGCHDC 1217
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY----GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1085-1127 1.87e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.09  E-value: 1.87e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1830925708  1085 CSCDPLGTaVPDTCDPRTGQCQCKVGVIGVKCHECQDGFFGLN 1127
Cdd:smart00180    1 CDCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 871-920 6.48e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 6.48e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1830925708  871 PCPCNGH---SNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPLQgtPHDCK 920
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1688-1733 7.69e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 7.69e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1688 CHCNGRSS---DCDKESGVCQnCRANSGGDHCQQCAEGFYGDP-NSPHGC 1733
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 571-618 1.45e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.82  E-value: 1.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  571 CECDERGTLSSDgsC---SGKCQCKLNVEGETCSECAPGYFDLSDRNPLGC 618
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1791-1836 1.46e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 1.46e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708  1791 CNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCLAERHHVVDNGC 1836
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1037-1085 4.00e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 1037 PCLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGFAHVDLRCPPC 1085
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
527-571 5.11e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 5.11e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708   527 CSCDPIRS-TGSCHPEGGRCNCLVGFQGNQCQECAPGYYGEECKPC 571
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1790-1825 8.17e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 8.17e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1830925708 1790 ACNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCL 1825
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCA 36
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 872-919 8.54e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 8.54e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  872 CPCNGH---SNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPlQGTPHDC 919
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1791-1825 1.26e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.26e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1830925708 1791 CNCNPDGIRAEGCDSETGQCYCREGVTGLKCSKCL 1825
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1038-1087 2.46e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 2.46e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708 1038 CLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGFaHVDLRCPPCSC 1087
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY-YGLPSDPPQGC 49
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2097-2408 3.04e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 3.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2097 DQGEELARLTLERQSLLSEhLNQLDGATVLLNATLGVKSEQQREVRKHwLPKAEKHADRLLERSNEyaRQFQPTRNGARI 2176
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKE-LEELEEELEQLRKELEELSRQISALRKD-LARLEAEVEQLEERIAQ--LSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2177 AILASSAHSNITKAInDARQGSILAKERVYDAQRTLypSDGSSMIE--RAKHSLHRSRQLQQEALKQMHKSNV------- 2247
Cdd:TIGR02168  764 EELEERLEEAEEELA-EAEAEIEELEAQIEQLKEEL--KALREALDelRAELTLLNEEAANLRERLESLERRIaaterrl 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2248 --LKEKLHQQQEQVEGIKATIFESGLRTNNISSQLQTLTDssARRHAKESLDLARRTGEQMRAELR----KAKETEESLQ 2321
Cdd:TIGR02168  841 edLEEQIEELSEDIESLAAEIEELEELIEELESELEALLN--ERASLEEALALLRSELEELSEELRelesKRSELRRELE 918

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2322 NMRKSftklepdwdiklgMAQENISLTKTNLRLANVsLSYLEQQAAKEQQVFESWNNSMAKQLQQLRDQIAKARHAAQAI 2401
Cdd:TIGR02168  919 ELREK-------------LAQLELRLEGLEVRIDNL-QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984


                   ....*...
gi 1830925708 2402 -DVSLESL 2408
Cdd:TIGR02168  985 gPVNLAAI 992
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1688-1733 5.85e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 5.85e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1830925708  1688 CHCNGR---SSDCDKESGVCQnCRANSGGDHCQQCAEGFYGDpnSPHGC 1733
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 526-573 9.55e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 9.55e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708  526 ACSCDPIRS-TGSCHPEGGRCNCLVGFQGNQCQECAPGYYGEECKPCEC 573
Cdd:cd00055      1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 570-618 9.74e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 9.74e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1830925708  570 PCECDERGTLSsdGSC---SGKCQCKLNVEGETCSECAPGYFDLSDRnPLGC 618
Cdd:cd00055      1 PCDCNGHGSLS--GQCdpgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 994-1038 1.13e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.13e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1830925708  994 CDC-----AGGPCNVTTGACItCKGNTEGWHCERCKLGYWGDPAVGCEPC 1038
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 527-573 2.36e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.66  E-value: 2.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708  527 CSCDPIRSTGS-CHPEGGRCNCLVGFQGNQCQECAPGYYG-EECKPCEC 573
Cdd:pfam00053    1 CDCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 993-1034 2.70e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.27  E-value: 2.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708  993 RCDC-----AGGPCNVTTGACItCKGNTEGWHCERCKLGYWGDPAVG 1034
Cdd:cd00055      1 PCDCnghgsLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
994-1035 3.03e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 3.03e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1830925708   994 CDC-----AGGPCNVTTGACiTCKGNTEGWHCERCKLGYWGDPAVGC 1035
Cdd:smart00180    1 CDCdpggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
571-618 3.55e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.55e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708   571 CECDERGtlSSDGSC---SGKCQCKLNVEGETCSECAPGYFdlsDRNPLGC 618
Cdd:smart00180    1 CDCDPGG--SASGTCdpdTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
872-914 3.62e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.62e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1830925708   872 CPCNG---HSNSCDLQSGNCgDCMHNTFGERCERCQLGFYGNPLQG 914
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1038-1075 3.73e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1830925708  1038 CLCHAEGSESGLCDSTDGQCLCKPRFAGQKCDDCDTGF 1075
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1736-1786 4.94e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 4.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708 1736 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNPTLYPNS 1786
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 2044-2466 5.99e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.28  E-value: 5.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2044 DLRLQLDrTLEVESEAEDIVEHVRNLNGHTAEAHHELNDLGQligkylNQSYLDQGEELARLTLERQSLLSEHLNQLDGA 2123
Cdd:TIGR00618  200 TLRSQLL-TLCTPCMPDTYHERKQVLEKELKHLREALQQTQQ------SHAYLTQKREAQEEQLKKQQLLKQLRARIEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2124 TVLLNATlgVKSEQQREVRKHWLPKAEkHADRLLERsnEYARQFQPTRNGARIAILASsahsnitkaindarqgsILAKE 2203
Cdd:TIGR00618  273 RAQEAVL--EETQERINRARKAAPLAA-HIKAVTQI--EQQAQRIHTELQSKMRSRAK-----------------LLMKR 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2204 RVYDAQRTLYPSDGSSMIERAKHSLHRSRQLQQEALKQMHKSN--VLKEKLHQQQEQVEGIKAtifesglRTNNISSQLQ 2281
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQqhTLTQHIHTLQQQKTTLTQ-------KLQSLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2282 TLTdssARRHAKESLDLARRTGEQMRAELRKAKETEESLQNMRKSFTKLEpdwdiklgmAQENIsLTKTNLRLANVSLSY 2361
Cdd:TIGR00618  404 ILQ---REQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCT---------AQCEK-LEKIHLQESAQSLKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2362 LEQQAAKEQQVFESWnnsmaKQLQQLRDQIAKaRHAAQAIDV--SLESLGPKCIRSYLPssyGLSTSNNLRLSFALANHi 2439
Cdd:TIGR00618  471 REQQLQTKEQIHLQE-----TRKKAVVLARLL-ELQEEPCPLcgSCIHPNPARQDIDNP---GPLTRRMQRGEQTYAQL- 540

                          410       420
                   ....*....|....*....|....*..
gi 1830925708 2440 esspliQVEGSEGRHITLELYKRRVRL 2466
Cdd:TIGR00618  541 ------ETSEEDVYHQLTSERKQRASL 561
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2304-2418 7.82e-06

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 47.87  E-value: 7.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2304 EQMRAELRKAKETEESLQNMRKSFtklePDWDIKLGMAQENISLTK-------TNLRLANVSLSYLEQQA------AKEQ 2370
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNL----ENTSEKLSGINRSLEETNelvndanKALDDAGRSVKKLEELApdlldkLKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1830925708 2371 QVFESWNNSMAKQLQQLRDQIAKARHAAQAIDVSLeSLGPKCIRSYLP 2418
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1735-1781 8.20e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.04  E-value: 8.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708 1735 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNPT 1781
Cdd:cd00055      1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLPS 44
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2185-2393 1.40e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.79  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2185 SNITKAINDARQgSILAKERvydaqrTLypsdgsSMIErAKHSLHRSRQLQQEALKQmhKSNVLKEKLHQQQEQVEGIKA 2264
Cdd:TIGR04523  183 LNIQKNIDKIKN-KLLKLEL------LL------SNLK-KKIQKNKSLESQISELKK--QNNQLKDNIEKKQQEINEKTT 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2265 TIfesglrtNNISSQLQTLTDSSarRHAKESLDlaRRTGEQMRAElRKAKETEESLQNMRKSFTKL----EPDW--DIK- 2337
Cdd:TIGR04523  247 EI-------SNTQTQLNQLKDEQ--NKIKKQLS--EKQKELEQNN-KKIKELEKQLNQLKSEISDLnnqkEQDWnkELKs 314

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2338 -LGMAQENISLTKTNLRLANVSLSYLEQQAA---KEQQVFESWNNSMAKQLQQLRDQIAK 2393
Cdd:TIGR04523  315 eLKNQEKKLEEIQNQISQNNKIISQLNEQISqlkKELTNSESENSEKQRELEEKQNEIEK 374
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1736-1780 1.83e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.22  E-value: 1.83e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1830925708  1736 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCHSGYFGNP 1780
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2126-2394 2.02e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2126 LLNATLGVKSEQQ-RE-VRKHWL--PKAEKHADRLLE---RSNEYARQFQPTRngARIAILA--SSAHSNITKAINDARQ 2196
Cdd:COG4913    196 LLHKTQSFKPIGDlDDfVREYMLeePDTFEAADALVEhfdDLERAHEALEDAR--EQIELLEpiRELAERYAAARERLAE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2197 GSILAKE-RVYDAQRTLypsdgssmiERAKHSLHRSRQLQQEALKQMhksNVLKEKLHQQQEQVEGIKATIFESGLRtnn 2275
Cdd:COG4913    274 LEYLRAAlRLWFAQRRL---------ELLEAELEELRAELARLEAEL---ERLEARLDALREELDELEAQIRGNGGD--- 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2276 issQLQTLTdsSARRHAKESLDLARRTGEQMRAELRKAK----ETEESLQNMRKSFTKLEPDWDIKLGMAQENISLTKTN 2351
Cdd:COG4913    339 ---RLEQLE--REIERLERELEERERRRARLEALLAALGlplpASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1830925708 2352 LRLANVSLsyleQQAAKEQQVFESWNNSMAKQLQQLRDQIAKA 2394
Cdd:COG4913    414 LRDLRREL----RELEAEIASLERRKSNIPARLLALRDALAEA 452
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1358-1410 3.29e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 3.29e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1830925708 1358 CGCNADGSFTRAdgliaCDSN-GQCPCKSLVVGLKCDTCMQSTFGLSALNPEGC 1410
Cdd:pfam00053    1 CDCNPHGSLSDT-----CDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2100-2409 6.45e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 6.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2100 EEL-ARL-TLERQS-------LLSEHLNQLDgATVLLNATLGVKSEQQRevrkhwlpkAEKHADRLLERSNEYARQFQpt 2170
Cdd:COG1196    196 GELeRQLePLERQAekaeryrELKEELKELE-AELLLLKLRELEAELEE---------LEAELEELEAELEELEAELA-- 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2171 RNGARIAILASsAHSNITKAINDARQGSILAKERVYDAQRTLypsdgSSMIERAKHSLHRSRQLQQEALKQMHKSNVLKE 2250
Cdd:COG1196    264 ELEAELEELRL-ELEELELELEEAQAEEYELLAELARLEQDI-----ARLEERRRELEERLEELEEELAELEEELEELEE 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2251 KLHQQQEQVEGIKATIFESglrTNNISSQLQTLTDSSARRHAKESLDLARRtgEQMRAELRKAKETEESLQNMRKSFTKL 2330
Cdd:COG1196    338 ELEELEEELEEAEEELEEA---EAELAEAEEALLEAEAELAEAEEELEELA--EELLEALRAAAELAAQLEELEEAEEAL 412

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1830925708 2331 EpdwDIKLGMAQENISLTKTNLRLANVSLSYLEQQAAKEQQVFESwNNSMAKQLQQLRDQIAKARHAAQAIDVSLESLG 2409
Cdd:COG1196    413 L---ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL-EEEEEALLELLAELLEEAALLEAALAELLEELA 487
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2230-2469 1.11e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.20  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2230 RSRQLQQEALKQmhKSNVLKEKLHQQQEQVEGIKATIFESGLRTNNISSQLQTLtdssarrhaKESLDLARRTGEQMRAE 2309
Cdd:COG4372     34 RKALFELDKLQE--ELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL---------NEQLQAAQAELAQAQEE 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2310 LRKAKETEESLQnmrKSFTKLEpdwdiklgmaQENISLTKTNlrlanvslsyleQQAAKEQQVFESWNNSMAKQLQQLRD 2389
Cdd:COG4372    103 LESLQEEAEELQ---EELEELQ----------KERQDLEQQR------------KQLEAQIAELQSEIAEREEELKELEE 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2390 QIAKARHAAQAIDVSLESLGPKCIRSYLPSSygLSTSNN----LRLSFALANHIESSPLIQVEGSEGRHITLELYKRRVR 2465
Cdd:COG4372    158 QLESLQEELAALEQELQALSEAEAEQALDEL--LKEANRnaekEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLAL 235


                   ....
gi 1830925708 2466 LVWN 2469
Cdd:COG4372    236 SALL 239
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1265-1310 2.93e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 2.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1830925708 1265 CSACTAEGQICDSHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1310
Cdd:cd00055      4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1358-1410 3.04e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.76  E-value: 3.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1830925708  1358 CGCNADGSFTRAdgliaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaLNPEGC 1410
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2046-2374 3.27e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2046 RLQLDRTLEVESEAEDIVEHV-RNLN-----GHTAEAHHEL-NDLGQLIGKYLNQSYLDQGEELARLTLERQSLLSEH-- 2116
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELeRQLKslerqAEKAERYKELkAELRELELALLVLRLEELREELEELQEELKEAEEELee 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2117 ----LNQLDGATVLLNATLGVKSEQQREVRKhwlpkaekhadRLLERSNEyarqfqptrngarIAILassahsNITKAIN 2192
Cdd:TIGR02168  258 ltaeLQELEEKLEELRLEVSELEEEIEELQK-----------ELYALANE-------------ISRL------EQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2193 DARQGSILAKERVYDAQRTlypsDGSSMIERAKHSLHRSRQLQQEALKQM-----------HKSNVLKEKLHQQQEQVEG 2261
Cdd:TIGR02168  308 RERLANLERQLEELEAQLE----ELESKLDELAEELAELEEKLEELKEELesleaeleeleAELEELESRLEELEEQLET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2262 IKATIFESGLRTNNISSQLQTLTD---SSARRHAKESLDLARRTGEQMRAELRKAKETEESLQNMRKSFTKLEPDWDIKL 2338
Cdd:TIGR02168  384 LRSKVAQLELQIASLNNEIERLEArleRLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEAL 463

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1830925708 2339 GMAQENISLTKTNLRLANVSLSYLEQQAAKEQQVFE 2374
Cdd:TIGR02168  464 EELREELEEAEQALDAAERELAQLQARLDSLERLQE 499
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 422-471 3.86e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.42  E-value: 3.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1830925708  422 DCHGHSDRTQE-APGSpvVQCVCQHNACGVQCEECCPLFQDRPYRLsEECE 471
Cdd:cd00055      3 DCNGHGSLSGQcDPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQG-GGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1357-1411 4.13e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.42  E-value: 4.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1830925708 1357 RCGCNADGSFTRAdgliaCDS-NGQCPCKSLVVGLKCDTCMQSTFGLsALNPEGCT 1411
Cdd:cd00055      1 PCDCNGHGSLSGQ-----CDPgTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2041-2403 4.97e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 4.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2041 RVVDLRLQLDRTLEV-ESEAEdivehvrnlnghTAEAHHELNDLGQLIGKYLNQSYLDQ--------GEELARLTLERQS 2111
Cdd:COG1196    190 RLEDILGELERQLEPlERQAE------------KAERYRELKEELKELEAELLLLKLREleaeleelEAELEELEAELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2112 LLSEH------LNQLDGATVLLNATLGVKSEQQREVRKHwLPKAEKHADRLLERSNEYARQFQptRNGARIAILAsSAHS 2185
Cdd:COG1196    258 LEAELaeleaeLEELRLELEELELELEEAQAEEYELLAE-LARLEQDIARLEERRRELEERLE--ELEEELAELE-EELE 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2186 NITKAINDARQGSILAKERVYDAQRTLypSDGSSMIERAKHSLH----RSRQLQQEALKQMHKSNVLKEKLHQQQEQVEG 2261
Cdd:COG1196    334 ELEEELEELEEELEEAEEELEEAEAEL--AEAEEALLEAEAELAeaeeELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2262 IKAtifesglRTNNISSQLQTLTDssARRHAKESLDLARRTGEQMRAELRKAKETEESLQNMRKSFTKLEPDWDIKLgma 2341
Cdd:COG1196    412 LLE-------RLERLEEELEELEE--ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL--- 479

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830925708 2342 qenisLTKTNLRLANVSLSYLEQQAAKEQQVFESWnnsmAKQLQQLRDQIAKARHAAQAIDV 2403
Cdd:COG1196    480 -----AELLEELAEAAARLLLLLEAEADYEGFLEG----VKAALLLAGLRGLAGAVAVLIGV 532
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2449-2524 9.47e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 9.47e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1830925708 2449 GSEGRHITLELYKRRVRLVWNLGGTTATVTHPmvvqtrdPKYDD-AWYHVEANRTLNLGSLLVrrmNNYGVLTPSSP 2524
Cdd:cd00110     43 QNGGDFLALELEDGRLVLRYDLGSGSLVLSSK-------TPLNDgQWHSVSVERNGRSVTLSV---DGERVVESGSP 109
Laminin_G_1 pfam00054
Laminin G domain;
2455-2577 1.09e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2455 ITLELYKRRVRLVWNLGGTTATVTHPmvvqtrdPKYDDA-WYHVEANRTLNLGSLLVrrmNNYGVLTPSSPVTITGSTDT 2533
Cdd:pfam00054   22 LALELRDGRLEVSYDLGSGAAVVRSG-------DKLNDGkWHSVELERNGRSGTLSV---DGEARPTGESPLGATTDLDV 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1830925708 2534 EhTRFYqsrndrisLGGFAS-----KDLQLTPGLNVVVHHVEVDNKPLG 2577
Cdd:pfam00054   92 D-GPLY--------VGGLPSlgvkkRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
2452-2510 1.41e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 41.17  E-value: 1.41e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708  2452 GRHITLELYKRRVRLVWNLGGTTATVTHPmvvqtrDPKYDD-AWYHVEANRTLNLGSLLV 2510
Cdd:smart00282   24 GDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2049-2322 1.97e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2049 LDRTlEVESEAEDIVEHVRNLNG-HTA--EAHHELNDLGQLIGKYlnQSYLDQGEELARLTLERQSL----LSEHLNQLD 2121
Cdd:COG4913    218 LEEP-DTFEAADALVEHFDDLERaHEAleDAREQIELLEPIRELA--ERYAAARERLAELEYLRAALrlwfAQRRLELLE 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2122 GATVLLNATLGVKSEQQREVRKHwlpkAEKHADRLLERSNEYARQfqptrNGARIAILASSAHsNITKAINDARQGSILA 2201
Cdd:COG4913    295 AELEELRAELARLEAELERLEAR----LDALREELDELEAQIRGN-----GGDRLEQLEREIE-RLERELEERERRRARL 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830925708 2202 KERVYDAQRTLYPS--DGSSMIERAKHSLHRSRQLQQEALKQMHKsnvLKEKLHQQQEQVEGIKATIFESGLRTNNISSQ 2279
Cdd:COG4913    365 EALLAALGLPLPASaeEFAALRAEAAALLEALEEELEALEEALAE---AEAALRDLRRELRELEAEIASLERRKSNIPAR 441

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1830925708 2280 LQTLtdssaRRHAKESLDLARrtgEQMR--AELRKAKETEESLQN 2322
Cdd:COG4913    442 LLAL-----RDALAEALGLDE---AELPfvGELIEVRPEEERWRG 478
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 963-991 3.22e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.72  E-value: 3.22e-03
                           10        20
                   ....*....|....*....|....*....
gi 1830925708  963 QCPEGFTGDHCQVCDDGYFGDPLQIGSSC 991
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2444-2510 5.75e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 39.33  E-value: 5.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1830925708 2444 LIQVEGSEGRHITLELYKRRVRLVWNLGGttatvtHPMVVQTRDPKYDD-AWYHVEANRTLNLGSLLV 2510
Cdd:pfam02210   10 LLYAGGGGSDFLALELVNGRLVLRYDLGS------GPESLLSSGKNLNDgQWHSVRVERNGNTLTLSV 71
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1270-1302 6.35e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 6.35e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1830925708 1270 AEGQICDSHNGRCICPKFTRGLGCGQCVPGTWG 1302
Cdd:pfam00053    8 SLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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