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Conserved domains on  [gi|1034674919|ref|XP_016885211|]
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BCL-6 corepressor-like protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1666-1779 9.63e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


:

Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.63e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1666 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1745
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034674919 1746 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1603 1.55e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.55e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|
gi 1034674919 1574 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
PHA03247 super family cl33720
large tegument protein UL36; Provisional
198-636 5.42e-16

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 84.60  E-value: 5.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247  2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247  2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247  2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034674919  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1666-1779 9.63e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.63e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1666 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1745
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034674919 1746 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
1667-1781 3.41e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 204.92  E-value: 3.41e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1667 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1746
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034674919 1747 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1781
Cdd:pfam16553   81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1603 1.55e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.55e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|
gi 1034674919 1574 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1500-1591 1.83e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1500 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1579
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
                           90
                   ....*....|..
gi 1034674919 1580 WLLLSYGADPTL 1591
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
198-636 5.42e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 84.60  E-value: 5.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247  2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247  2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247  2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034674919  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1497-1588 4.25e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.92  E-value: 4.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1497 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA03100   160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
                           90
                   ....*....|..
gi 1034674919 1577 ETIWLLLSYGAD 1588
Cdd:PHA03100   239 EIFKLLLNNGPS 250
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
218-664 2.48e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.93  E-value: 2.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154  251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154  391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154  449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919  601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
1530-1558 7.17e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 7.17e-06
                            10        20
                    ....*....|....*....|....*....
gi 1034674919  1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1489-1588 1.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1563
Cdd:cd22192     10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
                           90       100
                   ....*....|....*....|....*
gi 1034674919 1564 TRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:cd22192     90 ETALHIAVVNQNLNLVRELIARGAD 114
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
272-337 8.12e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 8.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034674919  272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601   75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
1666-1779 9.63e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.63e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1666 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1745
Cdd:cd14260      2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034674919 1746 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14260     82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
1667-1781 3.41e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 204.92  E-value: 3.41e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1667 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1746
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034674919 1747 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1781
Cdd:pfam16553   81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
PUFD_like cd14259
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ...
1668-1779 9.24e-43

PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271222  Cd Length: 106  Bit Score: 151.70  E-value: 9.24e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1668 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPg 1747
Cdd:cd14259      1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1034674919 1748 glddrSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14259     80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
1668-1779 1.11e-36

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271224  Cd Length: 117  Bit Score: 134.97  E-value: 1.11e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1668 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPG 1747
Cdd:cd14261      6 DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSCPKDLE 85
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1034674919 1748 GLDdrspPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14261     86 AFN----PDSKELLDLVEFTNELQTLLGSSLE 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1603 1.55e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 1.55e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
                           90       100       110
                   ....*....|....*....|....*....|
gi 1034674919 1574 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1605 3.21e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 3.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDsEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1034674919 1569 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS 1605
Cdd:COG0666    159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1484-1603 1.07e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.55  E-value: 1.07e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1484 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGAN 1555
Cdd:COG0666    133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1034674919 1556 VNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666    212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1603 8.33e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.08  E-value: 8.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034674919 1569 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1500-1591 1.83e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1500 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1579
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
                           90
                   ....*....|..
gi 1034674919 1580 WLLLSYGADPTL 1591
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
198-636 5.42e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 84.60  E-value: 5.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247  2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247  2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247  2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034674919  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1600 5.37e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 5.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666    184 NDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
                           90       100
                   ....*....|....*....|....*..
gi 1034674919 1574 DNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:COG0666    263 GAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1491-1557 3.41e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 3.41e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034674919 1491 VNKNAGETLLQRAARLGYKDVVLYCLQKdsEDVNHRDNaGYTALHEACSRGWTDILNILLEHGANVN 1557
Cdd:pfam12796   25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1497-1588 4.25e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.92  E-value: 4.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1497 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA03100   160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
                           90
                   ....*....|..
gi 1034674919 1577 ETIWLLLSYGAD 1588
Cdd:PHA03100   239 EIFKLLLNNGPS 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1534-1605 5.45e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 5.45e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034674919 1534 LHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASS 1605
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAAR 70
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1484-1603 5.75e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.37  E-value: 5.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1484 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEA--CSRGWTDILNILLE 1551
Cdd:PHA03100    86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1552 HGANVNcsAQD------------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:PHA03100   165 KGVDIN--AKNrvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
PHA03247 PHA03247
large tegument protein UL36; Provisional
181-609 1.53e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  181 TGVPVEGTLPLVTTNFSPLP-APICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPvqvatsvPAPSPPLAPVPALA 259
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVA 2789
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  260 PAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPlaliqAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PHA03247  2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----GPPPPSLPLGGSVAPGGDVRR 2864
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  340 PMPASTPPAapappsvpmptptpssgppstptlipafaptpvpaptpapifTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PHA03247  2865 RPPSRSPAA------------------------------------------KPAAPARPPVRRLARPAVSRSTESFALPP 2902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  420 VCFPAAQAPAMQKVPLSFQPgtvlTPSQPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPEL 499
Cdd:PHA03247  2903 DQPERPPQPQAPPPPQPQPQ----PPPPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  500 RSYPYAFSVARPLTSDSKLVSLEVNRL------------PCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKV-LPTPQP 566
Cdd:PHA03247  2978 RVPQPAPSREAPASSTPPLTGHSLSRVsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSdLEALDP 3057
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1034674919  567 LLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLER 609
Cdd:PHA03247  3058 LPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSR 3100
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
205-419 2.00e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.04  E-value: 2.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSvptlisdsnPLSVSASVLVP 284
Cdd:PRK12323   374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL---------AAARQASARGP 444
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  285 VPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAptlvlAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323   445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034674919  365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAaiPTSAPIPASFSLSR 419
Cdd:PRK12323   520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATE--PVVAPRPPRASASG 572
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
218-664 2.48e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.93  E-value: 2.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154  251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154  391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154  449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919  601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1485-1613 2.91e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 2.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1485 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGT 1564
Cdd:COG0666      9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034674919 1565 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLS 1613
Cdd:COG0666     89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYngnlEIVKLLLE 141
Ank_4 pfam13637
Ankyrin repeats (many copies);
1530-1582 1.10e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 1.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034674919 1530 GYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI-WLL 1582
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
1522-1599 1.14e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1522 DVNHRDNAGYTALHeACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN--LETIWLLLSYGADPTLATYSG 1596
Cdd:PHA03095   109 DVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRF 187

                   ...
gi 1034674919 1597 QTA 1599
Cdd:PHA03095   188 RSL 190
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1477-1588 1.23e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1477 PTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRG-WTDILNILLE 1551
Cdd:PHA02876   284 PSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLE 363
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1034674919 1552 HGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:PHA02876   364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1548-1627 1.40e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 1.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1548 ILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSDHLSDLQGRA 1623
Cdd:PTZ00322   100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEngfrEVVQLLSRHSQCHFELGA 179

                   ....
gi 1034674919 1624 EGDP 1627
Cdd:PTZ00322   180 NAKP 183
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1522-1600 2.61e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 2.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034674919 1522 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1531-1619 2.63e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 2.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1531 YTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1600
Cdd:PHA03100    36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
                           90
                   ....*....|....*....
gi 1034674919 1601 KLASSDTMKRFLSDHLSDL 1619
Cdd:PHA03100   116 KKSNSYSIVEYLLDNGANV 134
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1508-1603 3.10e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 3.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1508 YKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWT-DILNILLEHGANVNC-SAQDGTRPVHDAVVNDnlETIWLLLSY 1585
Cdd:PHA02878   212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
                           90
                   ....*....|....*...
gi 1034674919 1586 GADPTLATYSGQTAMKLA 1603
Cdd:PHA02878   290 GADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
1498-1550 3.30e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 3.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034674919 1498 TLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILL 1550
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
1516-1568 5.90e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 5.90e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034674919 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
1516-1588 6.74e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 6.74e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034674919 1516 LQKDSEDVNHRDNAGYTALHEACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1588
Cdd:PHA03095    33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
1530-1558 7.17e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 7.17e-06
                            10        20
                    ....*....|....*....|....*....
gi 1034674919  1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
287-649 7.72e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 7.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  287 ASAPPSGPVPLSAPAPAPL----SVPVS-------------------APPL-ALIQAPV-PPSAPTLVLAPVPTPVLAPM 341
Cdd:PHA03247  2544 ASDDAGDPPPPLPPAAPPAapdrSVPPPrpaprpsepavtsrarrpdAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHA 2623
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  342 PASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVC 421
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  422 FPAAQAPAMQKVPLSFQPGTVLTP---SQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYlqdrclPGVLASPE 498
Cdd:PHA03247  2700 DPPPPPPTPEPAPHALVSATPLPPgpaAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG------PPAPAPPA 2773
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  499 LRSYPYAFSVARPLTSdsklvSLEVNRLPCTSPSGSTttqPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPP 578
Cdd:PHA03247  2774 APAAGPPRRLTRPAVA-----SLSESRESLPSPWDPA---DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034674919  579 HPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1530-1558 4.59e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 4.59e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1034674919 1530 GYTALHEACSR-GWTDILNILLEHGANVNC 1558
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1522-1585 4.94e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 4.94e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919 1522 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSY 1585
Cdd:PTZ00322   107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1530-1558 1.12e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.70  E-value: 1.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 1034674919 1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1522-1605 1.48e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1522 DVNHRD-NAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02878   159 DINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                   ....*
gi 1034674919 1601 KLASS 1605
Cdd:PHA02878   239 HISVG 243
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1516-1579 1.69e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 1.69e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI 1579
Cdd:PHA02876   164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1490-1557 3.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.04  E-value: 3.74e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034674919 1490 IVNKNA-GETLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVN 1557
Cdd:PHA03100   185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03095 PHA03095
ankyrin-like protein; Provisional
1522-1617 4.05e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1522 DVNHRDNAGYTALHEA---CSRGWTDILNiLLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQT 1598
Cdd:PHA03095   214 DPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNT 292
                           90       100
                   ....*....|....*....|...
gi 1034674919 1599 AMKLA----SSDTMKRFLSDHLS 1617
Cdd:PHA03095   293 PLSLMvrnnNGRAVRAALAKNPS 315
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1516-1612 4.79e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1593
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
                           90
                   ....*....|....*....
gi 1034674919 1594 YSGQTAMKLASSDTMKRFL 1612
Cdd:PLN03192   624 DLLCTAAKRNDLTAMKELL 642
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
271-322 8.54e-04

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 41.77  E-value: 8.54e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034674919  271 DSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSApplALIQAPVP 322
Cdd:PRK05641    44 DLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGE---NVVTAPMP 92
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
197-336 1.04e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  197 SPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHsglvPVQVATSVPAPSPPLAPVPALApappsvptlisdSNPLS 276
Cdd:PRK14951   372 AAAPAEKKTPARPEAAAPAAAP----VAQAAAAPAPA----AAPAAAASAPAAPPAAAPPAPV------------AAPAA 431
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034674919  277 VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPV-SAPPLALIQAPVPPSAPTLVLAPVPTP 336
Cdd:PRK14951   432 AAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVrVAPEPAVASAAPAPAAAPAAARLTPTE 492
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1489-1588 1.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1563
Cdd:cd22192     10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
                           90       100
                   ....*....|....*....|....*
gi 1034674919 1564 TRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:cd22192     90 ETALHIAVVNQNLNLVRELIARGAD 114
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1497-1603 1.22e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1497 ETLLQRAARLGYKDVVlYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA02874   125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
                           90       100
                   ....*....|....*....|....*..
gi 1034674919 1577 ETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:PHA02874   204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1496-1588 1.48e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1496 GETLLQRAARLGYKDVVLYCLqKDSEDVNHRDNAGYTALHEACSRGWTDILNI--------------------------- 1548
Cdd:PLN03192   558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRIlyhfasisdphaagdllctaakrndlt 636
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1034674919 1549 ----LLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:PLN03192   637 amkeLLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
274-569 1.75e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  274 PLSVSASVLVPVPASAPPSG--PVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPvptpvlapmpastppaapa 351
Cdd:PRK12323   375 ATAAAAPVAQPAPAAAAPAAaaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA------------------- 435
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  352 ppsvpmptptpssgppstptlipafaptpvpaPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQ 431
Cdd:PRK12323   436 --------------------------------ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA 483
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  432 KVPLSFQPGTVLTPsqPLVYIPPpscgqplsvatlpttlgvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARP 511
Cdd:PRK12323   484 APAAAPAPADDDPP--PWEELPP----------------------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034674919  512 ltsdsklvSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLP 569
Cdd:PRK12323   540 --------TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
PHA03095 PHA03095
ankyrin-like protein; Provisional
1508-1590 1.96e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1508 YKDVVLyCLQKDSEDVNHRDNAGYTALH-EACSRGWTDILNILLEHGANVNCSAQDGTRPVHD--AVVNDNLETIWLLLS 1584
Cdd:PHA03095    62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140

                   ....*.
gi 1034674919 1585 YGADPT 1590
Cdd:PHA03095   141 KGADVN 146
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
274-337 2.71e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.71e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919  274 PLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLAlIQAPVPPSAPTLVLAPVPTPV 337
Cdd:PRK14951   391 AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-APAAAPAAAPAAVALAPAPPA 453
Ank_5 pfam13857
Ankyrin repeats (many copies);
1549-1603 3.10e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 3.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034674919 1549 LLEHG-ANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
273-471 3.24e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  273 NPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPtpvlapmpastppaapap 352
Cdd:PRK14951   372 AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA------------------ 433
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  353 psvpmptptpssgppstptlipafaptpvpaptpapiftPAPTPMPAATPAAIPTSAPIPAsfslsrvcfpaaqAPAMQK 432
Cdd:PRK14951   434 ---------------------------------------PAAAPAAAPAAVALAPAPPAQA-------------APETVA 461
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1034674919  433 VPLSFQPGTVLTPSqplvyiPPPSCGQPLSVATLPTTLG 471
Cdd:PRK14951   462 IPVRVAPEPAVASA------APAPAAAPAAARLTPTEEG 494
PHA02795 PHA02795
ankyrin-like protein; Provisional
1521-1563 3.32e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 41.90  E-value: 3.32e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034674919 1521 EDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDG 1563
Cdd:PHA02795   212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
206-335 3.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 3.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  206 PAPGSASVPHSVPDAfQVPLSVPAPVPHSGLVPvqvATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASvlVPV 285
Cdd:PRK07003   360 PAVTGGGAPGGGVPA-RVAGAVPAPGARAAAAV---GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP--APP 433
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034674919  286 PASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPT 335
Cdd:PRK07003   434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASD 483
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1544-1605 4.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 4.17e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919 1544 DILNILLEHGANVNCSAQDGTRPVHDAVVN--DNLETIWLLLSYGADPTLATYSGQTAMKLASS 1605
Cdd:PHA03100    87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE 150
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
180-353 4.18e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 4.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  180 GTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALA 259
Cdd:PRK07003   363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTA----VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  260 PAPPSVPTLisdsnPLSVSASVLVPVPASAPPSGPVPLSAPAPAplSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PRK07003   439 GDDAADGDA-----PVPAKANARASADSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDAR 511
                          170
                   ....*....|....
gi 1034674919  340 PMPASTPPAAPAPP 353
Cdd:PRK07003   512 APAAASREDAPAAA 525
PHA03247 PHA03247
large tegument protein UL36; Provisional
74-336 6.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919   74 ADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSwTPLNTQMSKQVD 153
Cdd:PHA03247  2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT-RPAVASLSESRE 2796
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  154 CSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPH 233
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  234 SGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPP 313
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
                          250       260
                   ....*....|....*....|....*.
gi 1034674919  314 LALIQAPVPPSAPTLVLAP---VPTP 336
Cdd:PHA03247  2957 GAVPQPWLGALVPGRVAVPrfrVPQP 2982
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
197-338 6.04e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 41.51  E-value: 6.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  197 SPLPAPICPPAPGSASVPHSVPDAFQ---------VPLSVPAPVPHSGLVPVQV-ATSVPAPSPPLAPVPALAPAPPSVP 266
Cdd:PRK12727    77 TKPAAPVHAPLKLSANANMSQRQRVAsaaedmiaaMALRQPVSVPRQAPAAAPVrAASIPSPAAQALAHAAAVRTAPRQE 156
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  267 TLISdSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLA-------------------LIQAPVPPSAPT 327
Cdd:PRK12727   157 HALS-AVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAyaqdddeqldddgfdlddaLPQILPPAALPP 235
                          170
                   ....*....|.
gi 1034674919  328 LVLAPVPTPVL 338
Cdd:PRK12727   236 IVVAPAAPAAL 246
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
284-337 7.51e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 40.29  E-value: 7.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034674919  284 PVPASAPPS--GPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPV 337
Cdd:pfam07174   41 PEPAPPPPStaTAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPA 96
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
272-337 8.12e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 8.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034674919  272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601   75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1545-1614 8.33e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 8.33e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034674919 1545 ILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSD 1614
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDskniDTIKAIIDN 233
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
197-329 8.38e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 8.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  197 SPLPAPICPPA---PGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSN 273
Cdd:PRK07994   363 APLPEPEVPPQsaaPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034674919  274 PLSVSASV--------LVPVPASAPPSGPVPLSAPA-------PAPLSVPVSAPPLALIQAPVPPSAPTLV 329
Cdd:PRK07994   443 PAAASRARpvnsalerLASVRPAPSALEKAPAKKEAyrwkatnPVEVKKEPVATPKALKKALEHEKTPELA 513
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
206-351 9.14e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 9.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  206 PAPGSASVPHSVPDAFQVPlSVPAPVPHSGLVPVQVATSVPAPspplapvpalapappsvptlisdsnPLSVSASVLVPV 285
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARP-EAAAPAAAPVAQAAAAPAPAAAP-------------------------AAAASAPAAPPA 419
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034674919  286 PASAPPSGPVPLSAPAPAPLSVPVSAPPlalIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPA 351
Cdd:PRK14951   420 AAPPAPVAAPAAAAPAAAPAAAPAAVAL---APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
1512-1600 9.15e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 41.05  E-value: 9.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919 1512 VLYCLQKDSEDVNHRDNAGYTALHEACSRGW--TDILNILLEHGANVNCSAQDGTRPVHD-----AVVND---------N 1575
Cdd:PHA02716   299 VVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlSVVNIldpetdndiR 378
                           90       100
                   ....*....|....*....|....*
gi 1034674919 1576 LETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02716   379 LDVIQCLISLGADITAVNCLGYTPL 403
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
278-406 9.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 9.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034674919  278 SASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPM 357
Cdd:PRK14951   367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034674919  358 PTPTPSSGPPSTPTLIPAFAPTPVPaptpapifTPAPTPMPAATPAAIP 406
Cdd:PRK14951   447 LAPAPPAQAAPETVAIPVRVAPEPA--------VASAAPAPAAAPAAAR 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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