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Conserved domains on  [gi|1034673433|ref|XP_016884730|]
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interleukin-1 receptor accessory protein-like 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR super family cl23801
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 279-433 5.26e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


The actual alignment was detected with superfamily member pfam01582:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 87.42  E-value: 5.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 279 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 358
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 359 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 418
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1034673433 419 NKLNSKFWKRLQYEM 433
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 22-108 3.25e-17

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 76.98  E-value: 3.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  22 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 97
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1034673433  98 VVRRTTELTVT 108
Cdd:cd05757    81 NVTRTISLTVT 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 129-224 3.83e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  129 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 207
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1034673433  208 CYVENGNGRRHASVLLH 224
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 279-433 5.26e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 87.42  E-value: 5.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 279 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 358
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 359 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 418
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1034673433 419 NKLNSKFWKRLQYEM 433
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
279-434 1.34e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 82.37  E-value: 1.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  279 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 358
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673433  359 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 434
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 22-108 3.25e-17

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 76.98  E-value: 3.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  22 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 97
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1034673433  98 VVRRTTELTVT 108
Cdd:cd05757    81 NVTRTISLTVT 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 129-224 3.83e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  129 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 207
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1034673433  208 CYVENGNGRRHASVLLH 224
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
122-224 4.08e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 48.02  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 122 MESKLTIQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 201
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 1034673433 202 DLGNYSCYVENGNGRRHASVLLH 224
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 35-208 7.58e-06

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 48.09  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  35 EISCRDIEDFLLPTREPEILW--YKECRTKTWR---PSIVfkrdtlLIREVREDDIGNYTCELK--YGG--FVVRRTTEL 105
Cdd:PHA02785  140 EMVCPNINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 106 TVTAPLTdkPPKLLYPmesklTIQETQLGDSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESD 176
Cdd:PHA02785  214 EVRDRII--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTD 285

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034673433 177 IRilkehlgeQEVSISLIVDSVEEGDLGNYSC 208
Cdd:PHA02785  286 KR--------RVITSRLNINPVKEEDATTFTC 309
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 137-220 3.49e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 137 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 216
Cdd:cd00096     1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                  ....
gi 1034673433 217 RHAS 220
Cdd:cd00096    65 SASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 50-107 3.99e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 3.99e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034673433   50 EPEILWYKECRTK-TWRPSIVFKRD----TLLIREVREDDIGNYTCELKYGGFVVRRTTELTV 107
Cdd:smart00410  23 PPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 50-107 8.32e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 8.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673433  50 EPEILWYKECrtktwrpSIVFKRDTLLIREVREDDIGNYTCELKYG-GFVVRRTTELTV 107
Cdd:pfam13895  28 PPSYTWYKDG-------SAISSSPNFFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 279-433 5.26e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 87.42  E-value: 5.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 279 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 358
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 359 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 418
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 1034673433 419 NKLNSKFWKRLQYEM 433
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
279-434 1.34e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 82.37  E-value: 1.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  279 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVR 358
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673433  359 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 434
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 22-108 3.25e-17

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 76.98  E-value: 3.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  22 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGG----F 97
Cdd:cd05757     1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                          90
                  ....*....|.
gi 1034673433  98 VVRRTTELTVT 108
Cdd:cd05757    81 NVTRTISLTVT 91
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 34-109 3.48e-08

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 51.06  E-value: 3.48e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034673433  34 KEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKY--GGFVVRRTTELTVTA 109
Cdd:cd20993    14 RTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYetKGRTIKLTRTVNVKV 91
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 297-386 1.91e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 50.01  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 297 TGEEERFALEILPDmLEKHyGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYvVRRGWSIFELETRLRnmLVT 376
Cdd:pfam13676   6 AGEDRAWAEWLADA-LEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNY-LESPWCRAEWEAALA--DPE 80

                          90
                  ....*....|..
gi 1034673433 377 GEIKVI--LIEC 386
Cdd:pfam13676  81 GRKRLIpvRLEC 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 129-224 3.83e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  129 QETQLGDSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNYS 207
Cdd:smart00410   4 VTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1034673433  208 CYVENGNGRRHASVLLH 224
Cdd:smart00410  68 CAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
122-224 4.08e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 48.02  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 122 MESKLTIQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 201
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 1034673433 202 DLGNYSCYVENGNGRRHASVLLH 224
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 115-212 8.69e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.79  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 115 PPKLLYPMESkltiQETQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVWESDirilkehlgeqeVSISLI 194
Cdd:pfam13927   1 KPVITVSPSS----VTVREGETVTLTCEA----TGSPPPTITWYKNGEPISSGSTRSRSLSG------------SNSTLT 60

                          90
                  ....*....|....*...
gi 1034673433 195 VDSVEEGDLGNYSCYVEN 212
Cdd:pfam13927  61 ISNVTRSDAGTYTCVASN 78
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 130-215 5.87e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 5.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 130 ETQLGDSANLTCRAFFGYSGdvsPLIYWMKGEKFIEDLDENRVWESDIRIlkehlgeqevsISLIVDSVEEGDLGNYSCY 209
Cdd:pfam00047   7 TVLEGDSATLTCSASTGSPG---PDVTWSKEGGTLIESLKVKHDNGRTTQ-----------SSLLISNVTKEDAGTYTCV 72


                  ....*.
gi 1034673433 210 VENGNG 215
Cdd:pfam00047  73 VNNPGG 78
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 35-208 7.58e-06

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 48.09  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  35 EISCRDIEDFLLPTREPEILW--YKECRTKTWR---PSIVfkrdtlLIREVREDDIGNYTCELK--YGG--FVVRRTTEL 105
Cdd:PHA02785  140 EMVCPNINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 106 TVTAPLTdkPPKLLYPmesklTIQETQLGDSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESD 176
Cdd:PHA02785  214 EVRDRII--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTD 285

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034673433 177 IRilkehlgeQEVSISLIVDSVEEGDLGNYSC 208
Cdd:PHA02785  286 KR--------RVITSRLNINPVKEEDATTFTC 309
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 22-107 9.20e-06

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 44.38  E-value: 9.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  22 MKYFEKAELSKSKEISCRDIEDFLLPTRE-PEILWYKECRT---KTWRpsIVFKRDTLLIREVREDDIGNYTCELKY--- 94
Cdd:cd20994     1 DFYKQKVPFTSGGRIVCPHLDFFKDENNNlPKVQWYKDCKPlllDDKR--FAGLESDLLIFNVTVQDQGNYTCHTSYtym 78

                          90
                  ....*....|....
gi 1034673433  95 -GGFVVRRTTELTV 107
Cdd:cd20994    79 gKQYNISRTISLIV 92
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 137-220 3.49e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 137 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 216
Cdd:cd00096     1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                  ....
gi 1034673433 217 RHAS 220
Cdd:cd00096    65 SASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 50-107 3.99e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 3.99e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034673433   50 EPEILWYKECRTK-TWRPSIVFKRD----TLLIREVREDDIGNYTCELKYGGFVVRRTTELTV 107
Cdd:smart00410  23 PPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 129-223 1.20e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 40.84  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 129 QETQLGDSANLTCRAffgySGDVSPLIYWMKgekfiedlDENRVWESDIRILKEHlgeqevsiSLIVDSVEEGDLGNYSC 208
Cdd:cd05725     7 QVVLVDDSAEFQCEV----GGDPVPTVRWRK--------EDGELPKGRYEILDDH--------SLKIRKVTAGDMGSYTC 66

                          90
                  ....*....|....*
gi 1034673433 209 YVENGNGRRHASVLL 223
Cdd:cd05725    67 VAENMVGKIEASATL 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 50-107 8.32e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 8.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673433  50 EPEILWYKECrtktwrpSIVFKRDTLLIREVREDDIGNYTCELKYG-GFVVRRTTELTV 107
Cdd:pfam13895  28 PPSYTWYKDG-------SAISSSPNFFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
Ig_C5_MyBP-C cd05894
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here ...
 148-223 9.00e-04

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here are composed of the C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C). MyBP-C consists of repeated domains, Ig and fibronectin type 3, and various linkers. Three isoforms of MYBP-C exist: slow-skeletal (ssMyBP-C), fast-skeletal (fsMyBP-C), and cardiac (cMyBP-C). cMYBP-C has insertions between and inside domains and an additional cardiac-specific Ig domain at the N-terminus. For cMYBP_C an interaction has been demonstrated between this C5 domain and the Ig C8 domain.


Pssm-ID: 409475  Cd Length: 86  Bit Score: 38.67  E-value: 9.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034673433 148 SGDVSPLIYWMKGEKFIEDlDENRVwesdirilkeHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLL 223
Cdd:cd05894    20 SGEPAPTVTWSRGDKAFTA-TEGRV----------RVESYKDLSSFVIEGAEREDEGVYTITVTNPVGEDHASLFV 84
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 50-91 2.19e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 2.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034673433  50 EPEILWYKE----CRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE 91
Cdd:cd00096    12 PPTITWYKNgkplPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
IgI_Myomesin_like_C cd05737
C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of ...
 127-215 2.51e-03

C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein (also known as myomesin-2). Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.


Pssm-ID: 319300  Cd Length: 92  Bit Score: 37.57  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 127 TIQEtqlGDSANLTCRAFfgysGDVSPLIYWMKGEKFIEDLDENRVWEsdirilkehlgEQEVSISLIVDSVEEGDLGNY 206
Cdd:cd05737    12 TIME---GKTLNLTCNVW----GDPPPEVSWLKNDQALAFLDHCNLKV-----------EAGRTVYFTINGVSSEDSGKY 73


                  ....*....
gi 1034673433 207 SCYVENGNG 215
Cdd:cd05737    74 GLVVKNKYG 82
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
 112-224 2.97e-03

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 37.04  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433 112 TDKPPKLLYpmeskltiqetQLGDSANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVWESDIRilkehlgeqevsi 191
Cdd:cd04978     3 IIEPPSLVL-----------SPGETGELICEA----EGNPQPTITWRLNGVPIEPAPEDMRRTVDGR------------- 54

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034673433 192 SLIVDSVEEGDLGNYSCYVENGNGRRHASVLLH 224
Cdd:cd04978    55 TLIFSNLQPNDTAVYQCNASNVHGYLLANAFLH 87
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 30-105 4.56e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.40  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673433  30 LSKSKEISCRDIEDfllpTREPEILWYKECRTKTWRPSIVFKRD-----TLLIREVREDDIGNYTCELKYGGFVVRRTTE 104
Cdd:pfam00047  10 EGDSATLTCSASTG----SPGPDVTWSKEGGTLIESLKVKHDNGrttqsSLLISNVTKEDAGTYTCVVNNPGGSATLSTS 85


                  .
gi 1034673433 105 L 105
Cdd:pfam00047  86 L 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 50-91 6.50e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 6.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034673433  50 EPEILWYKE----CRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE 91
Cdd:pfam13927  30 PPTITWYKNgepiSSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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