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Conserved domains on  [gi|1034628229|ref|XP_016884069|]
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transport and Golgi organization protein 2 homolog isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
1-311 5.37e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


:

Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.66  E-value: 5.37e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229   1 MCIIFFKFDPRPvsknAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQ 80
Cdd:pfam05742   1 MCILFFAWNAHP----KYPLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229  81 LD----WQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLS 156
Cdd:pfam05742  76 SGppdaVGARSRGLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 157 NALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG--- 233
Cdd:pfam05742 154 NSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpgg 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034628229 234 -YGTRycstvgapppipcptshargpakkpsahsqsqassspewipellpcpdaaagTNTIILVDADGHVTFTERSMMD 311
Cdd:pfam05742 229 rYGTR----------------------------------------------------SQTVILVDKDGKVTFIERTLYD 255
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
1-311 5.37e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.66  E-value: 5.37e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229   1 MCIIFFKFDPRPvsknAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQ 80
Cdd:pfam05742   1 MCILFFAWNAHP----KYPLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229  81 LD----WQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLS 156
Cdd:pfam05742  76 SGppdaVGARSRGLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 157 NALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG--- 233
Cdd:pfam05742 154 NSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpgg 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034628229 234 -YGTRycstvgapppipcptshargpakkpsahsqsqassspewipellpcpdaaagTNTIILVDADGHVTFTERSMMD 311
Cdd:pfam05742 229 rYGTR----------------------------------------------------SQTVILVDKDGKVTFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
1-328 2.25e-72

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 224.37  E-value: 2.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229   1 MCIIFFKFDPRPvsknAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGkegGTWLGISTRGKLAALTNYLQPQ 80
Cdd:COG3332     1 MCLIAFAWQPHP----DYPLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLEAG---GTWLGVNRHGRFAALTNRRDPS 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229  81 L-DWQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNAL 159
Cdd:COG3332    74 GpPAGARSRGELVLDFLAGESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNAL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 160 LETPWRKLCFGKQLFLEAVErsqalPKDVLIASLLDVLNNEE----AQLPDPAIedqgGEYVQPMLSkyaAVCVRCPGYG 235
Cdd:COG3332   149 LDTPWPKVARLKAALAAALA-----PDDPDPDALFALLADRTpapdAELPDTGV----GLEWERLLS---SIFIHGPGYG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 236 TRyCSTVgapppipcptshargpakkpsahsqsqassspewipellpcpdaaagtntiILVDADGHVTFTERSmMDKDLS 315
Cdd:COG3332   217 TR-SSTL---------------------------------------------------LALDADGRVEFAERR-FDADGP 243
                         330
                  ....*....|...
gi 1034628229 316 HWETRTYEFTLQS 328
Cdd:COG3332   244 PCGTRRFRFTLLS 256
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
1-311 5.37e-109

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 317.66  E-value: 5.37e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229   1 MCIIFFKFDPRPvsknAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEeGKEGGTWLGISTRGKLAALTNYLQPQ 80
Cdd:pfam05742   1 MCILFFAWNAHP----KYPLILAANRDEFLNRPTAPAHWWEENPNILGGRDLE-GREGGTWLGITKQGRIAALTNYREPS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229  81 LD----WQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLS 156
Cdd:pfam05742  76 SGppdaVGARSRGLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 157 NALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQGGEYVQPMlskyAAVCVRCPG--- 233
Cdd:pfam05742 154 NSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTGPEWERLL----SSIFIPPIPpgg 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034628229 234 -YGTRycstvgapppipcptshargpakkpsahsqsqassspewipellpcpdaaagTNTIILVDADGHVTFTERSMMD 311
Cdd:pfam05742 229 rYGTR----------------------------------------------------SQTVILVDKDGKVTFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
1-328 2.25e-72

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 224.37  E-value: 2.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229   1 MCIIFFKFDPRPvsknAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGkegGTWLGISTRGKLAALTNYLQPQ 80
Cdd:COG3332     1 MCLIAFAWQPHP----DYPLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLEAG---GTWLGVNRHGRFAALTNRRDPS 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229  81 L-DWQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNAL 159
Cdd:COG3332    74 GpPAGARSRGELVLDFLAGESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNAL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 160 LETPWRKLCFGKQLFLEAVErsqalPKDVLIASLLDVLNNEE----AQLPDPAIedqgGEYVQPMLSkyaAVCVRCPGYG 235
Cdd:COG3332   149 LDTPWPKVARLKAALAAALA-----PDDPDPDALFALLADRTpapdAELPDTGV----GLEWERLLS---SIFIHGPGYG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628229 236 TRyCSTVgapppipcptshargpakkpsahsqsqassspewipellpcpdaaagtntiILVDADGHVTFTERSmMDKDLS 315
Cdd:COG3332   217 TR-SSTL---------------------------------------------------LALDADGRVEFAERR-FDADGP 243
                         330
                  ....*....|...
gi 1034628229 316 HWETRTYEFTLQS 328
Cdd:COG3332   244 PCGTRRFRFTLLS 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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