NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034625819|ref|XP_016883552|]
View 

alpha-tocopherol transfer protein-like isoform X2 [Homo sapiens]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661176)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

CATH:  3.40.525.10|1.10.8.20
Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 128-243 7.02e-29

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 108.19  E-value: 7.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET----------------------------- 178
Cdd:cd00170     9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEqvegfvviidlkgfslsnlsdlsllkkll 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034625819 179 ---QDGFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGT 243
Cdd:cd00170    89 kilQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 9.31e-12

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.10  E-value: 9.31e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034625819   56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 128-243 7.02e-29

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 108.19  E-value: 7.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET----------------------------- 178
Cdd:cd00170     9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEqvegfvviidlkgfslsnlsdlsllkkll 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034625819 179 ---QDGFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGT 243
Cdd:cd00170    89 kilQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
128-242 4.27e-21

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 87.31  E-value: 4.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET----------------------------- 178
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLMPEgqvegltviidlkglslsnmdwwsisllk 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034625819 179 ------QDGFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLH-GSDLNSLHTNLPRSILPKEYGG 242
Cdd:pfam00650  81 kiikilQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 136-243 9.35e-18

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 78.50  E-value: 9.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819  136 TDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET---------------------------------QDGF 182
Cdd:smart00516  15 YDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEEKKtggiegftvifdlkglsmsnpdlsvlrkilkilQDHY 94

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034625819  183 PIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSD-LNSLHTNLPRSILPKEYGGT 243
Cdd:smart00516  95 PERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDsKEELLEYIDKEQLPEELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 9.31e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.10  E-value: 9.31e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034625819   56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 77-101 9.33e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 44.96  E-value: 9.33e-07
                          10        20
                  ....*....|....*....|....*
gi 1034625819  77 DDAFLLRFLRARKFDYDRALQLLVN 101
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 128-243 7.02e-29

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 108.19  E-value: 7.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET----------------------------- 178
Cdd:cd00170     9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEqvegfvviidlkgfslsnlsdlsllkkll 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034625819 179 ---QDGFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGT 243
Cdd:cd00170    89 kilQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
128-242 4.27e-21

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 87.31  E-value: 4.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET----------------------------- 178
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLMPEgqvegltviidlkglslsnmdwwsisllk 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034625819 179 ------QDGFPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLH-GSDLNSLHTNLPRSILPKEYGG 242
Cdd:pfam00650  81 kiikilQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 136-243 9.35e-18

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 78.50  E-value: 9.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625819  136 TDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEET---------------------------------QDGF 182
Cdd:smart00516  15 YDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEEKKtggiegftvifdlkglsmsnpdlsvlrkilkilQDHY 94

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034625819  183 PIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSD-LNSLHTNLPRSILPKEYGGT 243
Cdd:smart00516  95 PERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDsKEELLEYIDKEQLPEELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 9.31e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.10  E-value: 9.31e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034625819   56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 182-243 2.22e-07

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 49.25  E-value: 2.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034625819 182 FPIRIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGT 243
Cdd:pfam13716  73 FKKNLKAVYVVHPSTFLRTFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTELPGV 134
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 77-101 9.33e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 44.96  E-value: 9.33e-07
                          10        20
                  ....*....|....*....|....*
gi 1034625819  77 DDAFLLRFLRARKFDYDRALQLLVN 101
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH