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Conserved domains on  [gi|1034606227|ref|XP_016881788|]
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sperm acrosome membrane-associated protein 6 isoform X1 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10621882)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition

CATH:  2.60.40.10
PubMed:  10436082|9541533|7932691|8176743|23842991
SCOP:  3000071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 156-229 6.94e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 6.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034606227 156 QDVTVTRGDQAMFSCIVNFQlPKEEITysWKFAGGGLRTQDLSYFRDMPRaEGYLaRIRPAQLTHRGTFSCVIK 229
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGS-PPPTIT--WYKNGEPISSGSTRSRSLSGS-NSTL-TISNVTRSDAGTYTCVAS 77
 
Name Accession Description Interval E-value
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 156-229 6.94e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 6.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034606227 156 QDVTVTRGDQAMFSCIVNFQlPKEEITysWKFAGGGLRTQDLSYFRDMPRaEGYLaRIRPAQLTHRGTFSCVIK 229
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGS-PPPTIT--WYKNGEPISSGSTRSRSLSGS-NSTL-TISNVTRSDAGTYTCVAS 77
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 157-248 1.37e-03

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 37.53  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034606227 157 DVTVtrGDQAMFSCIVNFQlPKEEITYSWKFAGGGL---RTQDLSYFRDMPRAEGYLArIRPAQLTHRGTFSCVIkQDQR 233
Cdd:cd04970    13 DITV--GENATLQCHASHD-PTLDLTFTWSFNGVPIdleKIEGHYRRRYGKDSNGDLE-IVNAQLKHAGRYTCTA-QTVV 87

                          90
                  ....*....|....*
gi 1034606227 234 PLARLYFFLNVTGPP 248
Cdd:cd04970    88 DSDSASATLVVRGPP 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 156-229 1.96e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 1.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034606227  156 QDVTVTRGDQAMFSCIVNfqlPKEEITYSWKFAGGGLRTQDLSYFRDMPRAEGYLaRIRPAQLTHRGTFSCVIK 229
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTL-TISNVTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 156-229 6.94e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 6.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034606227 156 QDVTVTRGDQAMFSCIVNFQlPKEEITysWKFAGGGLRTQDLSYFRDMPRaEGYLaRIRPAQLTHRGTFSCVIK 229
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGS-PPPTIT--WYKNGEPISSGSTRSRSLSGS-NSTL-TISNVTRSDAGTYTCVAS 77
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 157-248 1.37e-03

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 37.53  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034606227 157 DVTVtrGDQAMFSCIVNFQlPKEEITYSWKFAGGGL---RTQDLSYFRDMPRAEGYLArIRPAQLTHRGTFSCVIkQDQR 233
Cdd:cd04970    13 DITV--GENATLQCHASHD-PTLDLTFTWSFNGVPIdleKIEGHYRRRYGKDSNGDLE-IVNAQLKHAGRYTCTA-QTVV 87

                          90
                  ....*....|....*
gi 1034606227 234 PLARLYFFLNVTGPP 248
Cdd:cd04970    88 DSDSASATLVVRGPP 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 156-229 1.96e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 1.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034606227  156 QDVTVTRGDQAMFSCIVNfqlPKEEITYSWKFAGGGLRTQDLSYFRDMPRAEGYLaRIRPAQLTHRGTFSCVIK 229
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTL-TISNVTPEDSGTYTCAAT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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