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Conserved domains on  [gi|1034604818|ref|XP_016881507|]
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neuropilin and tolloid-like protein 1 isoform X1 [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10035862)

CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to mammalian neuropilin and tolloid-like protein 2, an accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3, that increases kainate-receptor channel activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 51-154 7.46e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 7.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSG 130
Cdd:cd00041    11 GTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSG 89

                          90       100
                  ....*....|....*....|....
gi 1034604818 131 RFLWIKFFADGELESMGFSARYNF 154
Cdd:cd00041    90 NSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-286 8.21e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.04  E-value: 8.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818 200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGV-IRMWADEGSRNS 278
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLtVRFRSDSSVTGR 105


                  ....*...
gi 1034604818 279 RFQMLFTS 286
Cdd:cd00041   106 GFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 3.93e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 3.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034604818 292 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHC 326
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 51-154 7.46e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 7.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSG 130
Cdd:cd00041    11 GTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSG 89

                          90       100
                  ....*....|....*....|....
gi 1034604818 131 RFLWIKFFADGELESMGFSARYNF 154
Cdd:cd00041    90 NSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 51-152 1.93e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.80  E-value: 1.93e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818   51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPP-VIKSS 129
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSS 79

                           90       100
                   ....*....|....*....|...
gi 1034604818  130 GRFLWIKFFADGELESMGFSARY 152
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
51-152 4.56e-32

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.94  E-value: 4.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSG 130
Cdd:pfam00431  10 GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSS 88

                          90       100
                  ....*....|....*....|..
gi 1034604818 131 RFLWIKFFADGELESMGFSARY 152
Cdd:pfam00431  89 NQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-286 8.21e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.04  E-value: 8.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818 200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGV-IRMWADEGSRNS 278
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLtVRFRSDSSVTGR 105


                  ....*...
gi 1034604818 279 RFQMLFTS 286
Cdd:cd00041   106 GFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-284 9.94e-10

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.86  E-value: 9.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMW--ADEGSRN 277
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSSNSLTLTfvSDSSVQK 95


                   ....*..
gi 1034604818  278 SRFQMLF 284
Cdd:smart00042  96 RGFSARY 102
CUB pfam00431
CUB domain;
200-281 3.99e-09

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 54.22  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818 200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGlgvIRMWA----DEGS 275
Cdd:pfam00431  25 KDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSS---NQMTIkfvsDASV 101


                  ....*.
gi 1034604818 276 RNSRFQ 281
Cdd:pfam00431 102 QKRGFK 107
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 3.93e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 3.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034604818 292 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHC 326
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 51-154 7.46e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 7.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSG 130
Cdd:cd00041    11 GTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSG 89

                          90       100
                  ....*....|....*....|....
gi 1034604818 131 RFLWIKFFADGELESMGFSARYNF 154
Cdd:cd00041    90 NSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 51-152 1.93e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.80  E-value: 1.93e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818   51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPP-VIKSS 129
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSS 79

                           90       100
                   ....*....|....*....|...
gi 1034604818  130 GRFLWIKFFADGELESMGFSARY 152
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
51-152 4.56e-32

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.94  E-value: 4.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEkYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSG 130
Cdd:pfam00431  10 GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSS 88

                          90       100
                  ....*....|....*....|..
gi 1034604818 131 RFLWIKFFADGELESMGFSARY 152
Cdd:pfam00431  89 NQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-286 8.21e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.04  E-value: 8.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818 200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGV-IRMWADEGSRNS 278
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLtVRFRSDSSVTGR 105


                  ....*...
gi 1034604818 279 RFQMLFTS 286
Cdd:cd00041   106 GFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-284 9.94e-10

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.86  E-value: 9.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818  200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMW--ADEGSRN 277
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSSNSLTLTfvSDSSVQK 95


                   ....*..
gi 1034604818  278 SRFQMLF 284
Cdd:smart00042  96 RGFSARY 102
CUB pfam00431
CUB domain;
200-281 3.99e-09

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 54.22  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034604818 200 VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGlgvIRMWA----DEGS 275
Cdd:pfam00431  25 KDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSS---NQMTIkfvsDASV 101


                  ....*.
gi 1034604818 276 RNSRFQ 281
Cdd:pfam00431 102 QKRGFK 107
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 3.93e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 3.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034604818 292 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHC 326
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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