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Conserved domains on  [gi|1034601514|ref|XP_016880655|]
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CDK5 regulatory subunit-associated protein 3 isoform X2 [Homo sapiens]

Protein Classification

CDK5RAP3 family protein( domain architecture ID 10528880)

CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) family protein is a DUF773 domain-containing protein similar to vertebrate CDK5RAP3 that acts as a tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 1-410 5.03e-179

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


:

Pssm-ID: 461688  Cd Length: 506  Bit Score: 508.37  E-value: 5.03e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514   1 MKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGE 80
Cdd:pfam05600  91 MKDWQEIVRLYEKDNVYLAEAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514  81 NVRGELLALVKDLPSQLAEIGAAAQqSLGEAIDVYQASVGFVCESPTE--QVLPMLRFVQKRGNSTVYEWRTGTEPSVVE 158
Cdd:pfam05600 171 NVREELLELVKDLPSLFEKIAESLK-DLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIE 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 159 RPHLEELPEQVAE-----DAIDWGDfgveavsegtDSGISAEAAGIDWGIFPESDSKDPGGDGID---WGDDAVALQITV 230
Cdd:pfam05600 250 EPEVEVLTELQEAeeddgKEIDWGD----------DADGEVDAAEIDWGLGAVADDDVAEDEGGEidwGDSDMADIDISV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 231 LEAGT------QAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA-DVLSVSQFQLAPAILQGQTKE 303
Cdd:pfam05600 320 EESGIdveedvSVAGGVARGDDALSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPE 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 304 KMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLL 383
Cdd:pfam05600 400 EIEQMLSAVESALSLLTNPKTQHLFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLI 479

                         410       420
                  ....*....|....*....|....*..
gi 1034601514 384 EKTKELQKLIEADISKRYSGRPVNLMG 410
Cdd:pfam05600 480 EKTRELQKLIEKDLSKRYKGRPVNLMG 506
 
Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 1-410 5.03e-179

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


Pssm-ID: 461688  Cd Length: 506  Bit Score: 508.37  E-value: 5.03e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514   1 MKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGE 80
Cdd:pfam05600  91 MKDWQEIVRLYEKDNVYLAEAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514  81 NVRGELLALVKDLPSQLAEIGAAAQqSLGEAIDVYQASVGFVCESPTE--QVLPMLRFVQKRGNSTVYEWRTGTEPSVVE 158
Cdd:pfam05600 171 NVREELLELVKDLPSLFEKIAESLK-DLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIE 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 159 RPHLEELPEQVAE-----DAIDWGDfgveavsegtDSGISAEAAGIDWGIFPESDSKDPGGDGID---WGDDAVALQITV 230
Cdd:pfam05600 250 EPEVEVLTELQEAeeddgKEIDWGD----------DADGEVDAAEIDWGLGAVADDDVAEDEGGEidwGDSDMADIDISV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 231 LEAGT------QAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA-DVLSVSQFQLAPAILQGQTKE 303
Cdd:pfam05600 320 EESGIdveedvSVAGGVARGDDALSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPE 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 304 KMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLL 383
Cdd:pfam05600 400 EIEQMLSAVESALSLLTNPKTQHLFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLI 479

                         410       420
                  ....*....|....*....|....*..
gi 1034601514 384 EKTKELQKLIEADISKRYSGRPVNLMG 410
Cdd:pfam05600 480 EKTRELQKLIEKDLSKRYKGRPVNLMG 506
 
Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 1-410 5.03e-179

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


Pssm-ID: 461688  Cd Length: 506  Bit Score: 508.37  E-value: 5.03e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514   1 MKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGE 80
Cdd:pfam05600  91 MKDWQEIVRLYEKDNVYLAEAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514  81 NVRGELLALVKDLPSQLAEIGAAAQqSLGEAIDVYQASVGFVCESPTE--QVLPMLRFVQKRGNSTVYEWRTGTEPSVVE 158
Cdd:pfam05600 171 NVREELLELVKDLPSLFEKIAESLK-DLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIE 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 159 RPHLEELPEQVAE-----DAIDWGDfgveavsegtDSGISAEAAGIDWGIFPESDSKDPGGDGID---WGDDAVALQITV 230
Cdd:pfam05600 250 EPEVEVLTELQEAeeddgKEIDWGD----------DADGEVDAAEIDWGLGAVADDDVAEDEGGEidwGDSDMADIDISV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 231 LEAGT------QAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA-DVLSVSQFQLAPAILQGQTKE 303
Cdd:pfam05600 320 EESGIdveedvSVAGGVARGDDALSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPE 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601514 304 KMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLL 383
Cdd:pfam05600 400 EIEQMLSAVESALSLLTNPKTQHLFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLI 479

                         410       420
                  ....*....|....*....|....*..
gi 1034601514 384 EKTKELQKLIEADISKRYSGRPVNLMG 410
Cdd:pfam05600 480 EKTRELQKLIEKDLSKRYKGRPVNLMG 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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