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Conserved domains on  [gi|1370471477|ref|XP_016880291|]
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tetratricopeptide repeat protein 19, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12321303)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.17e-08

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471477 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-332 1.85e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260
                  ....*....|....*....|....*.
gi 1370471477 307 DLArqinhPELHMVLSNLAAVLMHRG 332
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQAC 228
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.17e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471477 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-332 1.85e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260
                  ....*....|....*....|....*.
gi 1370471477 307 DLArqinhPELHMVLSNLAAVLMHRG 332
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQAC 228
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-332 1.76e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 43.37  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|....*.
gi 1370471477 317 LHMVLSNLAAVLMHRG 332
Cdd:NF040586  477 TLMTAGGLGADLRALG 492
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-335 4.00e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.21  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586  620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699


                  ....*..
gi 1370471477 329 mhRGSGD 335
Cdd:NF040586  700 --RALGD 704
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 260-325 1.19e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370471477 260 YEKALQISEEIQ---------GERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLA 325
Cdd:NF040586  450 YEEARELDEDTLerqrrvlglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVfgeDHPRTLRAANNLA 527
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-335 1.41e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.29  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLmh 330
Cdd:NF040586  538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVAL-- 615


                  ....*
gi 1370471477 331 RGSGD 335
Cdd:NF040586  616 RRAGR 620
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-335 2.74e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 39.22  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370471477 262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRGSGD 335
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFHVDWLANAERVRVRLWLARGD 217
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 234-335 2.96e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.52  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 234 LLLGMCLdACARYLLfsKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN 313
Cdd:NF040586  647 LAAALSL-ANDLRAL--GDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEGLRERL 723

                          90       100
                  ....*....|....*....|....*
gi 1370471477 314 HPELHMVLS---NLAAVLMHRGSGD 335
Cdd:NF040586  724 GPDHPYTLAaavNLANDLAALGDLD 748
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 244-332 4.72e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 244 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPElhmVLSN 323
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPE---ALYL 90


                  ....*....
gi 1370471477 324 LAAVLMHRG 332
Cdd:COG4235    91 LGLAAFQQG 99
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 102-326 7.83e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 102 RAKLSIMKDEPEEAELILHDALRLayQTDNKKAITYtydlMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEI 181
Cdd:TIGR02917 471 LGAIYLGKGDLAKAREAFEKALSI--EPDFFPAAAN----LARIDIQEGNPDDAIQRFEK---------VLTIDPKNLRA 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 182 SLKLASIYAAQNRQEFAVAGYEFCIS----------TLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSK 251
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLEKAAElnpqeiepalALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAG 615

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370471477 252 QPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLAA 326
Cdd:TIGR02917 616 DLNKAVSSFKKLL--------ALQPDSALALLLLADAYAVMKNYAKAITSLKRA--LELKPDNTEAQIGLAQLLL 680
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-335 8.08e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 37.98  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586  569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                          90
                  ....*....|....*.
gi 1370471477 320 VLSNLAAVLmhRGSGD 335
Cdd:NF040586  649 AALSLANDL--RALGD 662
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.17e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471477 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-332 1.85e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260
                  ....*....|....*....|....*.
gi 1370471477 307 DLArqinhPELHMVLSNLAAVLMHRG 332
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQAC 228
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-332 1.76e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 43.37  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|....*.
gi 1370471477 317 LHMVLSNLAAVLMHRG 332
Cdd:NF040586  477 TLMTAGGLGADLRALG 492
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-335 4.00e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.21  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586  620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699


                  ....*..
gi 1370471477 329 mhRGSGD 335
Cdd:NF040586  700 --RALGD 704
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 260-325 1.19e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370471477 260 YEKALQISEEIQ---------GERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLA 325
Cdd:NF040586  450 YEEARELDEDTLerqrrvlglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVfgeDHPRTLRAANNLA 527
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-335 1.41e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.29  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLmh 330
Cdd:NF040586  538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVAL-- 615


                  ....*
gi 1370471477 331 RGSGD 335
Cdd:NF040586  616 RRAGR 620
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-335 2.74e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 39.22  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370471477 262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRGSGD 335
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFHVDWLANAERVRVRLWLARGD 217
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 234-335 2.96e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.52  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 234 LLLGMCLdACARYLLfsKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN 313
Cdd:NF040586  647 LAAALSL-ANDLRAL--GDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEGLRERL 723

                          90       100
                  ....*....|....*....|....*
gi 1370471477 314 HPELHMVLS---NLAAVLMHRGSGD 335
Cdd:NF040586  724 GPDHPYTLAaavNLANDLAALGDLD 748
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-332 4.05e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 102 RAKLSIMKDEPEEAELILHDALRLAYQTdnkkaiTYTYDLMANLAFIRGQLENAEQLFKATMSyllgggmKQEDNAiiEI 181
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELDPET------VEAHLALGNLYRRRGEYDRAIRIHQKLLE-------RDPDRA--EA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 182 SLKLASIYAAQNRQEFAVAGYEFCISTLEEKIE----------REKELAEDI-----MSVEEKANTHLLLGMcldacARY 246
Cdd:COG2956    79 LLELAQDYLKAGLLDRAEELLEKLLELDPDDAEalrllaeiyeQEGDWEKAIevlerLLKLGPENAHAYCEL-----AEL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 247 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAA 326
Cdd:COG2956   154 YLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ-----DPDYLPALPRLAE 220


                  ....*.
gi 1370471477 327 VLMHRG 332
Cdd:COG2956   221 LYEKLG 226
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 244-332 4.72e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 244 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPElhmVLSN 323
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPE---ALYL 90


                  ....*....
gi 1370471477 324 LAAVLMHRG 332
Cdd:COG4235    91 LGLAAFQQG 99
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 134-326 4.89e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 4.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 134 AITYTYDLMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKI 213
Cdd:COG2956     6 AAALGWYFKGLNYLLNGQPDKAIDLLEE---------ALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 214 EREKELAEDIMSVEEKANTHLLLGMCL-----DACARYLLFSKQpsQAQRMYEKALQISEEIQgERHPQTIVLMSDLATT 288
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLeldpdDAEALRLLAEIY--EQEGDWEKAIEVLERLL-KLGPENAHAYCELAEL 153

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370471477 289 LDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLAA 326
Cdd:COG2956   154 YLEQGDYDEAIEALEKA--LKLDPDCARALLLLAELYL 189
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 102-326 7.83e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 102 RAKLSIMKDEPEEAELILHDALRLayQTDNKKAITYtydlMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEI 181
Cdd:TIGR02917 471 LGAIYLGKGDLAKAREAFEKALSI--EPDFFPAAAN----LARIDIQEGNPDDAIQRFEK---------VLTIDPKNLRA 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 182 SLKLASIYAAQNRQEFAVAGYEFCIS----------TLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSK 251
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLEKAAElnpqeiepalALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAG 615

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370471477 252 QPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLAA 326
Cdd:TIGR02917 616 DLNKAVSSFKKLL--------ALQPDSALALLLLADAYAVMKNYAKAITSLKRA--LELKPDNTEAQIGLAQLLL 680
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-335 8.08e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 37.98  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586  569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                          90
                  ....*....|....*.
gi 1370471477 320 VLSNLAAVLmhRGSGD 335
Cdd:NF040586  649 AALSLANDL--RALGD 662
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 244-328 9.80e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 35.94  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471477 244 ARYLLFSKQPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSN 323
Cdd:COG4783    45 GEILLQLGDLDEAIVLLHEAL--------ELDPDEPEARLNLGLALLKAGDYDEALALLEKA--LKLDPEHPEAYLRLAR 114


                  ....*
gi 1370471477 324 LAAVL 328
Cdd:COG4783   115 AYRAL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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